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About 324,380 results

Challenges in managing a multifactorial eosinophilic pneumonia: daptomycin vs strongylo...
https://doi.org/10.1186/s12879-022-07852-y
BMC Infectious Diseases; Eckhardt LGJ, Kelley JL et. al.

Nov 25th, 2022 - Eosinophilia is defined as a blood eosinophil count > 500/mcL with etiology usually an allergic reaction or parasitic infection which can lead to serious organ damage. A patient being treated for hardware infection develops eosinophilia while on daptomycin in the setting of a positive strongyloides antibody. The patient was on chronic steroids prior to admission for epitheliopathy which complic...

Atrial-His bundle pacing in fulminant myocarditis with ventricular arrhythmia: a case r...
https://doi.org/10.1186/s12872-022-02936-8
BMC Cardiovascular Disorders; Jiang L, Wang L et. al.

Nov 25th, 2022 - Fulminant myocarditis is a clinical syndrome associated with threatening dysrhythmia which temporary pacemaker can be used for life-saving support. As a method of physiological pacing, His bundle pacing (HBP) maintain better cardiac synchronization than traditional right ventricular (RV) pacing. It's a severe case of fulminant myocarditis in a 41-year-old patient who presented for recurrent arr...

Odynophagia as the first manifestation of toxic epidermal necrolysis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693651
BMJ Case Reports; Ortega Beltrá N, Guallart Domenech F et. al.

Nov 25th, 2022 - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are infrequent mucocutaneous diseases, rapidly progressive and life-threatening. The clinical aspects and the management of TEN are exposed following a case.A man in his 40s presented to the emergency department with severe odynophagia, poor general condition and fever. His medical history was significant for HIV stage AIDS, an...

Rare case of ankylosing spondylitis complicated by IgA vasculitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693872
BMJ Case Reports; Kamath S, Ahmed T et. al.

Nov 25th, 2022 - Ankylosing spondylosis (AS) is characterised by bilateral sacroiliitis, asymmetric peripheral oligoarthritis, association with the human leucocyte antigen-B27, enthesitis and dactylitis. The association of IgA vasculitis with AS has been documented in few case reports. We present a rare case of a man in his 40s with AS, who presented with fever, bloody loose stools, abdominal pain, lower limb a...

Recurrent small bowel obstruction as a rare presentation of undiagnosed sarcoidosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693864
BMJ Case Reports; Naumann AA, Rodriguez VI et. al.

Nov 25th, 2022 - Sarcoidosis is an immune-mediated inflammatory disorder with unknown aetiology that is marked by non-caseating granulomas in affected organs. Pulmonary sarcoidosis is the most common manifestation, but gastrointestinal involvement, particularly in the small bowel, is exceedingly rare. While symptom-driven treatment guidelines that are steroid based are well established for pulmonary and few ext...

Venous Thromboembolism in the Inflammatory Rheumatic Diseases.
https://doi.org/10.1016/j.rdc.2022.08.001
Rheumatic Diseases Clinics of North America; Misra DP, Ahmed S et. al.

Nov 25th, 2022 - Venous thromboembolism (VTE), which includes deep venous thrombosis and pulmonary embolism, is a cardiovascular event whose risk is increased in most inflammatory rheumatic diseases (IRDs). Mechanisms that increase VTE risk include antiphospholipid antibodies (APLs), particularly anticardiolipin antibodies, anti-beta2glycoprotein I antibodies and lupus anticoagulant present together, and inflam...

Idiopathic Intracranial Hypertension and Vascular Anomalies in Chiari I Malformation.
https://doi.org/10.1016/j.nec.2022.09.008
Neurosurgery Clinics of North America; Lauzier DC, Chiang SN et. al.

Nov 25th, 2022 - Mounting evidence has suggested a relationship between Chiari I malformation and idiopathic intracranial hypertension, with some studies implicating anomalies of the cerebral venous system in the development of these conditions. However, precise mechanisms explaining these associations are not well described. There is a clear need to clarify the interplay between these conditions to guide furth...

Cerebrospinal Fluid Leaks, Spontaneous Intracranial Hypotension, and Chiari I Malformat...
https://doi.org/10.1016/j.nec.2022.08.012
Neurosurgery Clinics of North America; Kumar R, Cutsforth-Gregory JK et. al.

Nov 25th, 2022 - Spontaneous intracranial hypotension (SIH) occurs secondary to cerebrospinal fluid (CSF) hypovolemia in the setting of noniatrogenic spinal CSF leak. Although orthostatic headache is characteristic, atypical presentations can occur. Cranial imaging can disclose characteristic imaging features of SIH but spinal imaging is needed for leak localization. Although advanced diagnostic workup and trea...

Orthostatic Intolerance and Chiari I Malformation.
https://doi.org/10.1016/j.nec.2022.09.002
Neurosurgery Clinics of North America; Petracek LS, Rowe PC

Nov 25th, 2022 - Individuals with Chiari malformation can present with symptoms of fatigue, lightheadedness, and syncope-the cardinal features of orthostatic intolerance. Similar orthostatic symptoms can complicate the clinical course following Chiari decompression. The presence of orthostatic intolerance in patients with Chiari malformation is not surprising given the location of the major circulatory control ...

Biomarkers in Testicular Cancer: Classic Tumor Markers and Beyond.
https://doi.org/10.1016/j.ucl.2022.09.002
The Urologic Clinics of North America; Egan J, Salari K

Nov 25th, 2022 - Biomarkers play a key role in patients with testicular germ cell tumors in a variety of clinical contexts, including initial diagnosis, prognostication, monitoring treatment response, and posttreatment surveillance. Although the classic serum tumor markers for testicular germ cell tumors are essential for clinical management, the low sensitivity (particularly for seminoma and teratoma) and pote...

Current and Future Biomarkers in the Management of Renal Cell Carcinoma.
https://doi.org/10.1016/j.ucl.2022.09.003
The Urologic Clinics of North America; Reese S, Calderon L et. al.

Nov 25th, 2022 - Renal cell carcinoma biomarkers include serum, urine, liquid, and tissue biomarkers. There is currently an ongoing search for predictive biomarkers in the detection, recurrence, and treatment of renal cell carcinoma. Emerging signatures in the transcriptomic and translational biomarker space seem promising, although additional work is needed to validate candidates in a larger and more generaliz...

Pathophysiology and Clinical Biomarkers in Interstitial Cystitis.
https://doi.org/10.1016/j.ucl.2022.09.006
The Urologic Clinics of North America; Masterson JM, Castañeda PR et. al.

Nov 25th, 2022 - Interstitial cystitis/bladder pain syndrome is a poorly understood yet prevalent condition accounting for a significant proportion of urology office visits. Identification of reliable biomarkers for disease remains an important yet challenging area of research given the heterogeneity of disease presentation and pathophysiology. A review of the literature by the authors revealed a handful of ori...

Development and validation of machine learning-based risk prediction models of oral squ...
https://doi.org/10.1186/s12903-022-02607-2
BMC Oral Health; Tseng YJ, Wang YC et. al.

Nov 25th, 2022 - The incidence of oral cavity squamous cell carcinoma (OSCC) continues to rise. OSCC is associated with a low average survival rate, and most patients have a poor disease prognosis because of delayed diagnosis. We used machine learning techniques to predict high-risk cases of OSCC by using salivary autoantibody levels and demographic and behavioral data. We collected the salivary samples of pati...

Metastatic carcinoma mimicking hemophagocytic lymphohistiocytosis.
https://doi.org/10.1182/blood.2022018091
Blood De Lancy S, Oduro KA

Nov 25th, 2022 - Metastatic carcinoma mimicking hemophagocytic lymphohistiocytosis.|2022|De Lancy S,Oduro KA,|diagnosis,

Economic evaluation of COVID-19 rapid antigen screening programs in the workplace.
https://doi.org/10.1186/s12916-022-02641-5
BMC Medicine; Vilches TN, Rafferty E et. al.

Nov 25th, 2022 - Diagnostic testing has been pivotal in detecting SARS-CoV-2 infections and reducing transmission through the isolation of positive cases. We quantified the value of implementing frequent, rapid antigen (RA) testing in the workplace to identify screening programs that are cost-effective. To project the number of cases, hospitalizations, and deaths under alternative screening programs, we adapted...

Petrous apex's dural arteriovenous fistula (DAVF) mimicking a pineal region tumour: a r...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693661
BMJ Case Reports; Guarrera B, Cavasin N et. al.

Nov 25th, 2022 - A dural arteriovenous fistula (DAVF) is a dural-based shunt between meningeal arteries and meningeal veins, sinuses and/or cortical veins; they have been classified and named according to the location and the flow pattern. Petrous apex DAVFs are located where the petrosal vein penetrates the dura mater into the superior petrosal sinus; there are only few cases reported in the literature, they c...

Transcatheter Treatment of Mitral Regurgitation in Cardiogenic Shock: Promises and Pitf...
https://doi.org/10.1016/j.jacc.2022.09.028
Journal of the American College of Cardiology; Lurz P, Besler C

Nov 25th, 2022 - Transcatheter Treatment of Mitral Regurgitation in Cardiogenic Shock: Promises and Pitfalls.|2022|Lurz P,Besler C,|diagnosis,etiology,surgery,etiology,therapy,surgery,

Imaging in Chiari I Malformation.
https://doi.org/10.1016/j.nec.2022.08.006
Neurosurgery Clinics of North America; Pindrik J, McAllister AS et. al.

Nov 25th, 2022 - Chiari I Malformation represents a hindbrain anomaly best demonstrated radiographically with MRI. Brain and spine MRI provide optimal anatomic detail of cerebellar tonsillar descent below the foramen magnum and may reveal additional imaging features including ventriculomegaly (potentially leading to the diagnosis of hydrocephalus), characteristics of intracranial hypertension or hypotension, sp...

Study protocol for developing a novel approach for improving supply chain management fo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693879
BMJ Open; Maluleke K, Musekiwa A et. al.

Nov 25th, 2022 - Recent evidence shows that point-of-care (POC) testing is a more feasible alternative for diagnosis of COVID-19 in settings that have poor access to laboratory diagnostic services. Equitable access to POC testing can be optimised through well-established supply chain management (SCM) systems. The proposed study aims to develop a novel approach for improving SCM for COVID-19 POC diagnostic servi...

Pancreatic Tumorigenesis: Precursors, Genetic Risk Factors and Screening.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689647
Current Oncology (Toronto, Ont.); Badheeb M, Abdelrahim A et. al.

Nov 25th, 2022 - Pancreatic cancer (PC) is a highly malignant and aggressive tumor. Despite medical advancement, the silent nature of PC results in only 20% of all cases considered resectable at the time of diagnosis. It is projected to become the second leading cause in 2030. Most pancreatic cancer cases are diagnosed in the advanced stages. Such cases are typically unresectable and are associated with a 5-yea...