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About 313,680 results

Variation in SARS-CoV-2 outbreaks across sub-Saharan Africa.
https://doi.org/10.1038/s41591-021-01234-8
Nature Medicine; Rice BL, Annapragada A et. al.

Feb 3rd, 2021 - A surprising feature of the SARS-CoV-2 pandemic to date is the low burdens reported in sub-Saharan Africa (SSA) countries relative to other global regions. Potential explanations (for example, warmer environments1, younger populations2-4) have yet to be framed within a comprehensive analysis. We synthesized factors hypothesized to drive the pace and burden of this pandemic in SSA during the per...

Primary angiitis of the central nervous system: description of the first fifty-two adul...
https://doi.org/10.1002/art.38340
Arthritis & Rheumatology (Hoboken, N.J.); de Boysson H, Zuber M et. al.

May 1st, 2014 - To describe characteristics and outcomes of a multicenter cohort of patients diagnosed as having primary angiitis of the central nervous system (PACNS). In 2010, we initiated a cohort study of adults diagnosed as having PACNS ≤15 years ago and with followup of >6 months (unless they died earlier of biopsy-proven PACNS). Its first analysis was planned at 2 years. Multidisciplinary investigators ...

The neuropsychiatry of tinnitus: a circuit-based approach to the causes and treatments ...
https://doi.org/10.1136/jnnp-2013-307339
Journal of Neurology, Neurosurgery, and Psychiatry; Minen MT, Camprodon J et. al.

Apr 19th, 2014 - Patients presenting with tinnitus commonly have neuropsychiatric symptoms with which physicians need to be familiar. We provide an overview of tinnitus, including its types and pathophysiology. We discuss how recent methods such as transcranial magnetic stimulation, positron emission tomography, MRI, magnetoencephalography and quantitative EEG improve our understanding of the pathophysiology of...

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129545
The Lancet. Neurology; Boxer AL, Lang AE et. al.

May 30th, 2014 - In preclinical studies, davunetide promoted microtubule stability and reduced tau phosphorylation. Because progressive supranuclear palsy (PSP) is linked to tau pathology, davunetide could be a treatment for PSP. We assessed the safety and efficacy of davunetide in patients with PSP. In a double-blind, parallel group, phase 2/3 trial, participants were randomly assigned with permuted blocks in ...

Nonselective β blockers increase risk for hepatorenal syndrome and death in patients wi...
https://doi.org/10.1053/j.gastro.2014.03.005
Gastroenterology Mandorfer M, Bota S et. al.

Mar 18th, 2014 - Nonselective β blockers (NSBBs) reduce portal pressure and the risk for variceal hemorrhage in patients with cirrhosis. However, development of spontaneous bacterial peritonitis (SBP) in these patients could preclude treatment with NSBBs because of their effects on the circulatory reserve. We investigated the effects of NSBBs in patients with cirrhosis and ascites with and without SBP. We perfo...

Actionable diagnosis of neuroleptospirosis by next-generation sequencing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134948
The New England Journal of Medicine; Wilson MR, Naccache SN et. al.

Jun 4th, 2014 - A 14-year-old boy with severe combined immunodeficiency presented three times to a medical facility over a period of 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically induced coma. Diagnostic workup including brain biopsy was unrevealing. Unbiased next-generation sequencing of the cerebrospinal fluid identified 475 of 3,063,784 se...

Practice guidelines for the diagnosis and management of skin and soft tissue infections...
https://doi.org/10.1093/cid/ciu296
Clinical Infectious Diseases : an Official Publication Of... Stevens DL, Bisno AL et. al.

Jun 20th, 2014 - A panel of national experts was convened by the Infectious Diseases Society of America (IDSA) to update the 2005 guidelines for the treatment of skin and soft tissue infections (SSTIs). The panel's recommendations were developed to be concordant with the recently published IDSA guidelines for the treatment of methicillin-resistant Staphylococcus aureus infections. The focus of this guideline is...

Pediatric mycosis fungoides in Singapore: a series of 46 children.
https://doi.org/10.1111/pde.12352
Pediatric Dermatology; Heng YK, Koh MJ et. al.

Jun 3rd, 2014 - Few studies have evaluated Asian children with mycosis fungoides (MF). We report a series of patients from a tertiary dermatologic institution in Singapore. A retrospective review was performed of patients younger than 16 years old diagnosed with MF between 2000 and 2008 at the National Skin Centre, Singapore. Forty-six patients were identified. At initial presentation, a provisional diagnosis ...

Early lung ultrasonography predicts the occurrence of acute respiratory distress syndro...
https://doi.org/10.1007/s00134-014-3382-9
Intensive Care Medicine; Leblanc D, Bouvet C et. al.

Jul 15th, 2014 - Extent of lung contusion on initial computed tomography (CT) scan predicts the occurrence of acute respiratory distress syndrome (ARDS) in blunt chest trauma patients. We hypothesized that lung ultrasonography (LUS) on admission could also predict subsequent ARDS. Forty-five blunt trauma patients were prospectively studied. Clinical examination, chest radiography, and LUS were performed on arri...

A test for Creutzfeldt-Jakob disease using nasal brushings.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186748
The New England Journal of Medicine; Orrú CD, Bongianni M et. al.

Aug 7th, 2014 - Definite diagnosis of sporadic Creutzfeldt-Jakob disease in living patients remains a challenge. A test that detects the specific marker for Creutzfeldt-Jakob disease, the prion protein (PrP(CJD)), by means of real-time quaking-induced conversion (RT-QuIC) testing of cerebrospinal fluid has a sensitivity of 80 to 90% for the diagnosis of sporadic Creutzfeldt-Jakob disease. We have assessed the ...

Colonoscopy is associated with a reduced risk for colon cancer and mortality in patient...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297589
Clinical Gastroenterology and Hepatology : the Official C... Ananthakrishnan AN, Cagan A et. al.

Jul 21st, 2014 - Crohn's disease and ulcerative colitis are associated with an increased risk of colorectal cancer (CRC). Surveillance colonoscopy is recommended at 2- to 3-year intervals beginning 8 years after diagnosis of inflammatory bowel disease (IBD). However, there have been no reports of whether colonoscopy examination reduces the risk for CRC in patients with IBD. In a retrospective study, we analyzed...

Starting lithium prophylaxis early v. late in bipolar disorder.
https://doi.org/10.1192/bjp.bp.113.142802
The British Journal of Psychiatry : the Journal of Mental... Kessing LV, Vradi E et. al.

Jul 11th, 2014 - No study has investigated when preventive treatment with lithium should be initiated in bipolar disorder. To compare response rates among patients with bipolar disorder starting treatment with lithium early v. late. Nationwide registers were used to identify all patients with a diagnosis of bipolar disorder in psychiatric hospital settings who were prescribed lithium during the period 1995-2012...

Seasonal variation of relapse rate in multiple sclerosis is latitude dependent.
https://doi.org/10.1002/ana.24287
Annals of Neurology; Spelman T, Gray O et. al.

Oct 6th, 2014 - Previous studies assessing seasonal variation of relapse onset in multiple sclerosis have had conflicting results. Small relapse numbers, differing diagnostic criteria, and single region studies limit the generalizability of prior results. The aim of this study was to determine whether there is a temporal variation in onset of relapses in both hemispheres and to determine whether seasonal peak ...

Prevalence of small-bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy.
https://doi.org/10.1136/gutjnl-2014-307348
Gut Haanstra JF, Al-Toma A et. al.

Sep 11th, 2014 - The aim was to determine the prevalence of small-bowel neoplasia in asymptomatic patients with Lynch syndrome (LS) by video capsule endoscopy (VCE). After obtaining informed consent, asymptomatic proven gene mutation carriers aged 35-70 years were included in this prospective multicentre study in the Netherlands. Patients with previous small-bowel surgery were excluded. After bowel preparation,...

Eosinophilic esophagitis in adults is associated with IgG4 and not mediated by IgE.
https://doi.org/10.1053/j.gastro.2014.05.036
Gastroenterology Clayton F, Fang JC et. al.

Jun 7th, 2014 - Eosinophilic esophagitis is usually triggered by foods, by unclear mechanisms. We evaluated the roles of IgE and IgG4 in the development of eosinophilic esophagitis. We performed a prospective, randomized, double-blind, placebo-controlled trial of adults with eosinophilic esophagitis given an antibody against IgE (omalizumab, n = 16) or placebo (n = 14) every 2-4 weeks for 16 weeks, based on we...

Moving toward "laboratory-supported" criteria for psychogenic tremor.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664413
Movement Disorders : Official Journal of the Movement Dis... Schwingenschuh P, Katschnig P et. al.

Sep 30th, 2011 - A confident clinical diagnosis of psychogenic tremor is often possible, but, in some cases, a "laboratory-supported" level of certainty would aid in early positive diagnosis. Various electrophysiological tests have been suggested to identify patients with psychogenic tremor, but their diagnostic reliability has never been assessed "head to head" nor compared to forms of organic tremor other tha...

Risk factors for pulmonary artery hypertension in preterm infants with moderate or seve...
https://doi.org/10.1159/000327891
Neonatology Kim DH, Kim HS et. al.

Jul 27th, 2011 - Despite the potential importance of pulmonary artery hypertension (PAH) in preterm infants with bronchopulmonary dysplasia (BPD), little is known about the risk factors for PAH. To investigate the risk factors for PAH in preterm infants with BPD. Infants diagnosed with BPD were assigned to the PAH group or non-PAH group except for infants with mild BPD who had no PAH. PAH was diagnosed on the b...

Three-dimensional echocardiographic assessment of right ventricular volume and function...
https://doi.org/10.1016/j.echo.2009.11.002
Journal of the American Society of Echocardiography : Off... Grewal J, Majdalany D et. al.

Dec 7th, 2009 - The aim of this study was to evaluate the accuracy of three-dimensional (3D) ultrasound compared with the standard magnetic resonance imaging method in determining right ventricular (RV) volumes and function in adult patients with congenital heart disease and chronic, severe pulmonary regurgitation (PR). Twenty-five patients with severe PR secondary to either pulmonary valvotomy or tetralogy of...

Guidelines for the management of vitiligo: the European Dermatology Forum consensus.
https://doi.org/10.1111/j.1365-2133.2012.11197.x
The British Journal of Dermatology; Taieb A, Alomar A et. al.

Aug 6th, 2012 - The aetiopathogenic mechanisms of vitiligo are still poorly understood, and this has held back progress in diagnosis and treatment. Up until now, treatment guidelines have existed at national levels, but no common European viewpoint has emerged. This guideline for the treatment of segmental and nonsegmental vitiligo has been developed by the members of the Vitiligo European Task Force and other...

The impact of comorbid posttraumatic stress disorder on bipolar disorder patients.
https://doi.org/10.1016/j.jad.2009.08.005
Journal of Affective Disorders; Quarantini LC, Miranda-Scippa A et. al.

Sep 7th, 2009 - Available data regarding posttraumatic stress disorder (PTSD) in bipolar disorder (BD) are scarce and usually from a limited sample size. The present report was carried out using the Brazilian Research Consortium for Bipolar Disorders and aimed to examine whether patients with BD and comorbid PTSD are at an increased risk for worse clinical outcomes. A consecutive sample of bipolar I outpatient...