About 253,520 results

Retinal fluorescence imaging helps identify early functional changes

Jan 19th, 2022 - WAIKOLOA, Hawaii — Fluorescence imaging can be an important tool for early detection of retinal diseases, according to a presentation at Retina 2022. Rishi P. Singh, MD, said that technologies such as fundus autofluorescence (FAF), fluorescence lifetime imaging ophthalmoscopy (FLIO) and oxidized flavoprotein fluorescence (FPF) provide opportunities to identify cell dysfunction before it occurs....

Consensus group provides imaging criteria for assessment of geographic atrophy

Jan 19th, 2022 - WAIKOLOA, Hawaii — In a series of published reports, the Classification of Atrophy Meeting group provided consensus-based imaging parameters for multimodal assessment of geographic atrophy. The group also revised the definitions of specific features of geographic atrophy (GA) and identified features that may predict progression to atrophy. “In the first CAM report, we described the imaging moda...

Natural History and Development of Spondyloarthritis

Sep 28th, 2022 - The purpose of this protocol is to study the natural history of spondyloarthritis (SpA) in children and adults. Spondyloarthritis encompasses a spectrum of immune-mediated inflammatory diseases that exhibit overlapping features, but differ from other types of inflammatory arthritis in genetic predisposition, pathogenesis, and outcome. Ankylosing spondylitis (AS), the most common form of SpA, fr...

2019 Update of the American College of Rheumatology/Spondylitis Association of America/...
Arthritis & Rheumatology (Hoboken, N.J.); Ward MM, Deodhar A et. al.

Aug 23rd, 2019 - To update evidence-based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA). We conducted updated systematic literature reviews for 20 clinical questions on pharmacologic treatment addressed in the 2015 guidelines, and for 26 new questions on pharmacologic treatment, treat-to-target strategy, and use of imaging. New q...

Cardiac Sarcoidosis: An Underdiagnosed, Life-threatening yet Treatable Disease
Patrick Webster, Yogita Rochlani2 and Konstantinos Loupasakis, Rheumatology Fellow at Montefiore et. al.

Nov 14th, 2022 - Background/Purpose: Cardiac sarcoidosis (CS) is potentially life-threatening and it typically causes heart failure, ventricular arrhythmia, AV block or sudden death. CS has been reported to account for 25% of sarcoidosis patient deaths, thus highlighting the importance of early diagnosis and treatment. Diagnostic challenges and lack of a unified screening approach make it difficult to estimate ...

Autoantibodies Are Common in Patients with Idiopathic Interstitial Lung Disease Suggesting a High Prevalence of Undiagnosed Autoimmune Connective Tissue Disease
Sarah Tansley, Caroline Cotton, Fionnuala McMorrow et. al.

Nov 14th, 2022 - Background/Purpose: In some patients, interstitial lung disease (ILD) may be the dominant or even sole overt manifestation of an otherwise unrecognised autoimmune connective tissue disease (CTD). Accurate diagnosis can be challenging given considerable overlap of the clinical, radiological and histological disease features. Distinguishing CTD related ILD from idiopathic ILD, enables appropriate...

Auto-antibodies Targeting Membrane Repair Proteins Enhances Myositis Phenotype
Shane Bruckner, Kassidy Banford, hannah Bulgart et. al.

Nov 14th, 2022 - Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of disorders in which autoimmune responses produce a chronic state of inflammation resulting in degeneration of skeletal muscle structure and function. Our previous work generated a robust model of inflammatory myositis by combining a mouse with impaired sarcolemmal membrane repair synaptotagmin VII (SytVII)-/- with a mous...

Lenabasum Reduces IFNγ and pIRF3 in Dermatomyositis Skin: Biomarker Results from a Double-Blind Phase 3 International Randomized Controlled Trial
Thomas Vazquez, Meena Sharma, Rui Feng et. al.

Nov 14th, 2022 - Background/Purpose: Dermatomyositis (DM) is an autoimmune connective tissue disease that primarily affects the skin and lung; few effective treatment options are available. Lenabasum is a cannabinoid type 2 receptor agonist that activates the resolution phase of inflammation. Results from DETERMINE, a Phase 3 trial of lenabasum, demonstrated improvement in CDASI activity (CDASI-A) scores with t...

Chimeric Autoantigen-T Cell Receptor (CATCR)-T Cell Therapies to Selectively Target Autoreactive B Cells
Brian J. Mog, Elana R. Shaw, Michael S. Hwang et. al.

Nov 14th, 2022 - Background/Purpose: Chimeric antigen receptor (CAR)-T cell therapies have revolutionized the treatment of cancer and can be curative. CD19-targeted CAR-T cells hold promise for the treatment of refractory autoimmune diseases, but therapies that indiscriminately deplete all B cells are limited by infection risk. In contrast, precision immunotherapies that selectively eliminate autoreactive B cel...

FAM13A (Family with Sequence Similarity 13 Member A) Polymorphism Is Associated with Presence of a Radiographic Usual Interstitial Pneumonia Pattern in Patients with Systemic Sclerosis-Associated I...
Elana Bernstein, Francesco Boin, Brett Elicker et. al.

Nov 14th, 2022 - Background/Purpose: The pathogenesis of SSc-associated interstitial lung disease (ILD) is incompletely understood. The MUC5B promoter gain-of-function single nucleotide polymorphism (SNP) rs35705950 has been associated with idiopathic pulmonary fibrosis (IPF), familial pulmonary fibrosis (FPF), and RA-ILD, but not with SSc-ILD. Overexpression of MUC5B has been found in honeycombed pulmonary tis...

Sex-Related Differences in Healthcare Utilization in Patients with Inflammatory Arthritis: A Population-based Study
Sanjana Tarannum, Jessica Widdifield, C. Fangyun Wang et. al.

Nov 14th, 2022 - Background/Purpose: Delayed diagnosis of inflammatory arthritis (IA), including rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA), is associated with joint damage and disability. Thus, timely rheumatology access is necessary for favorable disease outcomes. Sex of the patient may influence various aspects of IA including healthcare utilization patterns. Our aim...

Age-Dependent Expansion and Activation of Disease-Associated Microglia in Neuropsychiatric Symptoms of Systemic Lupus Erythematosus
Hadijat Makinde, Caroline Shah, Miranda Gurra et. al.

Nov 14th, 2022 - Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multipe end organs, including the brain. Despite a prevalence of over 50% in SLE patients depending on the attribution model, neuropsychiatric symptoms of SLE (NPSLE) are among the least understood complications. Notwithstanding the paucity of data examining underlying mechanisms, accumulating ev...

Skeletal Myopathy in Systemic Sclerosis Associates with Higher Disease Burden and Mortality
Julie Paik, Caoilfhionn Connolly, Fredrick Wigley1 and Laura Hummers et. al.

Nov 14th, 2022 - Background/Purpose: Skeletal myopathy in systemic sclerosis (SSc) is poorly understood. The etiology of myopathy in SSc is heterogeneous and can result from an inflammation, disuse, malnutrition, or other neuromuscular diseases. The purpose of this study was to determine the clinical phenotype and risk of mortality of SSc patients with and without a myopathy. Methods: To understand the clinical...

Development of the Takayasu’s Arteritis Integrated Disease Activity Index
Chiara Marvisi, Ertugrul Cagri Bolek, Mark Ahlman et. al.

Nov 14th, 2022 - Background/Purpose: Disease activity indices that accurately assess inflammation in Takayasu’s arteritis (TAK) are needed. While clinical assessment is often considered the gold standard, determining if a symptom represents active vasculitis or damage can be challenging in TAK. FDG-PET can directly assess vascular inflammation but specificity of imaging findings, especially in absence of corres...

Complete Resolution of Inflammation on MRI Is Associated with a Better Clinical Response over Time in Patients with Early Axial Spondyloarthritis
valeria Rios-Rodriguez, Murat Torgutalp, Christian Althoff et. al.

Nov 14th, 2022 - Background/Purpose: Magnetic resonance imaging (MRI) of the spine and sacroiliac joints (SIJ) are important tools for the diagnosis of axial SpA and the presence of inflammation at baseline is associated with a better treatment response. However, data on the relevance of the complete resolution of inflammation / the presence of residual inflammation for a clinical response over time is missing....

Increased Brain Functional Connectivity to the Insula Is Associated with Nociplastic Pain in Psoriatic Arthritis
Flavia Sunzini, Kristian Stefanov, Salim Al-Wasity et. al.

Nov 14th, 2022 - Background/Purpose: Pain is a hallmark feature of psoriatic arthritis (PsA); however, its apparent multi-factorial nature makes it difficult for rheumatologists to assess and manage. Clinically, nociplastic processes appear to contribute to the PsA pain experience, as shown by frequent co-existing fibromyalgia (FM), a prototypical nociplastic pain disorder [1,2]. Yet there are no objective data...

Higher Matrix Metalloproteinase Levels Are Predictive of Incident Interstitial Lung Disease Among a Cohort of US Veterans with Rheumatoid Arthritis
Brent Luedders, Dana Ascherman, Joshua Baker et. al.

Nov 14th, 2022 - Background/Purpose: Matrix metalloproteinases (MMPs) degrade extracellular matrix and have been implicated to play a role in a number of fibrotic processes. Specifically, MMPs have been speculated to play a role in the pathogenesis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) as well as idiopathic pulmonary fibrosis (IPF), which shares historadiological features with RA...

Platelet-selectin Prime Lupus Neutrophils to Produce Mitochondrial ROS and Participate in SLE Pathogenesis
Marc Scherlinger, Pierre Vacher, Vivien Guillotin et. al.

Nov 14th, 2022 - Background/Purpose: In patients with active systemic lupus erythematosus (SLE), circulating platelets have an activated phenotype characterized by the expression of P-selectin (CD62P). We have shown that in human SLE, platelets interact with T regulatory cells and repress their immunosuppressive functions through a P-selectin/CD15s-dependent interaction (1). We sought to investigate for other p...

Plasmacytoid Dendritic Cells Are Not Major Producers of Type 1 Interferons in Cutaneous Lupus
Thomas Vazquez, Nilesh Kodali, DeAnna Diaz et. al.

Nov 14th, 2022 - Background/Purpose: Type 1 interferons (IFN-1) are major drivers of disease activity in systemic (SLE) and cutaneous lupus erythematosus (CLE). Plasmacytoid dendritic cells (pDCs) are the major producers of IFN-1 during viral infection. Therefore, pDCs have been hypothesized to be the primary IFN-1 producing cell in lupus. IFN-1 production by pDCs has not been extensively studied due to relianc...

Assessment of the Ultrasound and Clinical Response to Apremilast Using a Joint-periarticular-nail Ultrasound Index and Clinical Evaluation in Patients with Active Psoriatic Arthritis
Juan Josè de Agustin, Gustavo Añez, delia reina et. al.

Nov 14th, 2022 - Background/Purpose: Psoriatic arthritis (PsA) is a chronic inflammatory disease involving joint and enthesis disease. Ultrasound (US) has demonstrated its useful tool for the diagnosis of PsA and monitoring of inflammatory lesions in PsA. Our purpose is to conduct a study using US to evidence inflammatory changes in the joint and in the entheses in patients with active PsA (aPsA) who started Ap...