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About 197,045 results

Changes in Ventricular and Cortical Volumes following Shunt Placement in Patients with ...
https://doi.org/10.3174/ajnr.A7323
AJNR. American Journal of Neuroradiology; Cogswell PM, Murphy MC et. al.

Oct 23rd, 2021 - While changes in ventricular and extraventricular CSF spaces have been studied following shunt placement in patients with idiopathic normal pressure hydrocephalus, regional changes in cortical volumes have not. These changes are important to better inform disease pathophysiology and evaluation for copathology. The purpose of this work is to investigate changes in ventricular and cortical volume...

Anatomic Neuroimaging Characteristics of Posterior Fossa Type A Ependymoma Subgroups.
https://doi.org/10.3174/ajnr.A7322
AJNR. American Journal of Neuroradiology; Sabin ND, Hwang SN et. al.

Oct 23rd, 2021 - Posterior fossa type A (PFA) ependymomas have 2 molecular subgroups (PFA-1 and PFA-2) and 9 subtypes. Gene expression profiling suggests that PFA-1 and PFA-2 tumors have distinct developmental origins at different rostrocaudal levels of the brainstem. We, therefore, tested the hypothesis that PFA-1 and PFA-2 ependymomas have different anatomic MR imaging characteristics at presentation. Two neu...

GGC Repeat Expansion of NOTCH2NLC in Taiwanese Patients With Inherited Neuropathies.
https://doi.org/10.1212/WNL.0000000000013008
Neurology Liao YC, Chang FP et. al.

Oct 23rd, 2021 - The GGC repeat expansion in the 5' untranslated region of NOTCH2NLC was recently identified as the cause of neuronal intranuclear inclusion disease (NIID), which may manifest with peripheral neuropathy. The aim of this study is to investigate its contribution to inherited neuropathy. This cohort study screened patients with molecularly undiagnosed Charcot-Marie-Tooth disease (CMT) and healthy c...

18F-FDG PET improves baseline clinical predictors of response in diffuse large B-cell l...
https://doi.org/10.2967/jnumed.121.262205
Journal of Nuclear Medicine : Official Publication, Socie... Burggraaff CN, Eertink JJ et. al.

Oct 23rd, 2021 - We aimed to determine the added value of baseline metabolic tumor volume (MTV) and interim positron emission tomography (I-PET) to age-adjusted international prognostic index (aaIPI) to predict 2-year progression-free survival (PFS) in diffuse large B-cell lymphoma (DLBCL). Secondary objectives were to investigate optimal I-PET response criteria (using Deauville score (DS) - or quantitative cha...

Thymoma-associated autoimmune enteropathy with colonic stricture: a diagnostic and hist...
https://doi.org/10.1007/s12328-021-01531-2 10.1038/cmi.2010.74 10.3109/08916930903555935 10.1080/08880010050211420 10.1007/s00428-017-2243-7 10.1016/j.cgh.2007.05.013 10.1056/NEJMcpc1406663 10.1093/ajcp/112.6.810 10.1007/s10620-005-2666-x 10.1007/s00428-018-2304-6 10.1007/s11894-012-0276-2 10.14309/crj.0000000000000520 10.1111/j.1572-0241.2004.40039.x 10.1136/gut.50.2.206
Clinical Journal of Gastroenterology; Pieplenbosch B, de Leijer JH et. al.

Oct 23rd, 2021 - Thymoma-associated autoimmune enteropathy is a rare paraneoplastic syndrome that is characterized by severe chronic diarrhea, malabsorption, and specific histological findings. Because of its rarity, it is difficult to diagnose. We describe an adult patient with protracted diarrhea and weight loss that developed recurrent sepsis and progressive colonic stenosis due to thymoma-associated autoimm...

Prognostic Radiological Tools for Clinical Stage IA Pure Solid Lung Cancer.
https://doi.org/10.3390/curroncol28050328
Current Oncology (Toronto, Ont.); Nakada T, Takahashi Y et. al.

Oct 23rd, 2021 - In this study, we analyzed prognostic radiological tools and surgical outcomes for radiologically pure solid adenocarcinomas (AD) and squamous cell carcinoma (SQ) in clinical stage IA. We retrospectively investigated 130 patients who underwent surgical resections. We assessed the predictive risk factors for recurrence and pathological lymph node metastasis (LNM). There was no statistical differ...

Recent Advances in Photodynamic Imaging and Therapy in Hepatobiliary Malignancies: Clin...
https://doi.org/10.3390/curroncol28050345
Current Oncology (Toronto, Ont.); Nanashima A, Hiyoshi M et. al.

Oct 23rd, 2021 - The therapeutic and diagnostic modalities of light are well known, and derivative photodynamic reactions with photosensitizers (PSs), specific wavelengths of light exposure and the existence of tissue oxygen have been developed since the 20th century. Photodynamic therapy (PDT) is an effective local treatment for cancer-specific laser ablation in malignancies of some organs, including the bile ...

MR findings suggestive of idiopathic intracranial hypertension in 117 patients with spo...
https://doi.org/10.1007/s00234-021-02840-6 10.1177/000348940611500703 10.3171/2011.3.JNS101447 10.1016/j.otohns.2008.12.060 10.1016/j.otohns.2003.12.018 10.1212/WNL.0b013e3182a55f17 10.1177/0194599814551122 10.2214/AJR.13.10874 10.3174/ajnr.A2404 10.2500/ajra.2010.24.3465 10.3171/2012.4.FOCUS1265 10.1002/lary.24160 10.1007/s00405-017-4455-5 10.2500/ajr.2007.21.3026 10.1055/s-0037-1603731 10.1055/s-0037-1606306 10.1177/1945892420932490 10.1007/s00234-006-0095-y 10.1016/j.ejrad.2019.04.023 10.1002/1522-2586(200012)12:6<808::AID-JMRI3>3.0.CO;2-N 10.1016/S0161-6420(98)99039-X 10.3174/ajnr.A5055 10.1080/01658107.2018.1493514 10.1258/ar.2012.110705 10.1097/WNO.0000000000000761 10.1016/j.mjafi.2015.11.012 10.1212/WNL.0000000000002318 10.1002/lary.26612
Neuroradiology Rupa V, Jasper A et. al.

Oct 23rd, 2021 - The purpose of this study is to document the prevalence of MR findings suggestive of idiopathic intracranial hypertension (IIH) in patients undergoing endoscopic repair of spontaneous CSF rhinorrhea (SCSFR). In a retrospective study, MR images of 117 consecutive patients who had undergone endoscopic repair of SCSFR were evaluated for features suggestive of IIH (empty sella, widened optic nerve ...

Pamidronate Therapy Increases Trabecular Bone Complexity of Mandibular Condyles in Indi...
https://doi.org/10.1007/s00223-021-00915-3 10.1016/S0140-6736(04)16051-0 10.1007/s00198-016-3723-3 10.1038/nrdp.2017.52 10.1016/S0140-6736(15)00728-X 10.1016/S0140-6736(78)90763-8 10.1002/ajmg.a.37365 10.1002/ajmg.a.61366 10.1002/ajmg.a.36545 10.1016/0030-4220(84)90206-8 10.1111/j.1600-0714.1994.tb00082.x 10.1177/0022034514529150 10.1007/s00223-020-00707-1 10.1038/bdjopen.2017.21 10.1186/s12903-018-0497-3 10.1179/crn.2007.022 10.1016/S8756-3282(00)00269-6 10.1172/JCI0215952 10.1016/j.bone.2006.10.010 10.1002/jbmr.2567 10.1590/1678-4685-gmb-2018-0097 10.1177/0022034514567334 10.1259/dmfr.20150400 10.1016/j.oooo.2019.07.001 10.2147/DDDT.S141075 10.1111/odi.12950 10.1016/j.oooo.2019.12.009 10.1016/j.oooo.2019.03.002 10.1007/s11282-019-00388-z 10.1007/s10278-011-9383-0 10.5455/aim.2019.27.167-170 10.1038/sj.dmfr.4600630 10.14219/jada.archive.1996.0134 10.1016/j.oooo.2016.11.005 10.1016/j.maturitas.2013.10.011 10.1016/S1079-2104(99)70097-1 10.1097/01.prs.0000169940.69315.9c 10.1007/s00330-010-1828-1 10.1016/j.coms.2017.09.002 10.1007/s00223-021-00835-2 10.1007/s00784-012-0882-2 10.1016/S8756-3282(00)00353-7 10.4172/2161-1122.1000154 10.1002/14651858.CD005088.pub4 10.1016/j.nut.2011.04.003
Calcified Tissue International; Pantoja LLQ, Lustosa M et. al.

Oct 23rd, 2021 - Patients with Osteogenesis Imperfecta (OI) present extra-skeletal manifestations, including important orodental and craniofacial features as dentinogenesis imperfecta, dental agenesis, failure of maxilla growth and hypotonia of masticatory muscles. These features may compromise vital functions speech and mastication. Studies have demonstrated that cyclic pamidronate infusion, the standard thera...

Hiding in (Not So) Plain Sight: Spontaneous Tumor Lysis Syndrome due to Intravascular L...
https://doi.org/10.1002/ajh.26383
American Journal of Hematology; Ho M, Zanwar S et. al.

Oct 23rd, 2021 - Tumor lysis syndrome (TLS) is an oncologic emergency characterized by metabolic derangements (e.g., hyperkalemia, hyperphosphatemia, hypocalcemia, and hyperuricemia) and clinical complications (e.g., renal failure, cardiac arrhythmia, new-onset seizure). It most often occurs in the setting of large tumor burden, specifically when rapidly dividing, chemosensitive cancer cells are treated with cy...

Parkinsonism and cerebrospinal fluid disorders.
https://doi.org/10.1016/j.jns.2021.120019
Journal of the Neurological Sciences; Youn J, Todisco M et. al.

Oct 23rd, 2021 - Although various motor manifestations can be seen in patients with cerebrospinal fluid (CSF) disorders, such as hydrocephalus or intracranial hypotension, the clinical presentation with parkinsonism is not clearly elucidated. We searched the literature for studies describing the occurrence of parkinsonism in subjects with normal pressure hydrocephalus (NPH), obstructive hydrocephalus, and intra...

Assessment and Management of Loose Bodies in the Knee Joint and Related Disease: A Narr...
https://doi.org/10.2174/1573397117666211021165807
Current Rheumatology Reviews; Zmerly H, Moscato M et. al.

Oct 23rd, 2021 - Loose bodies are frequently encountered during clinical activity and a common finding during knee arthroscopy. Usually, treatment consists of the removal of the loose bodies, which can be challenging even for experienced surgeons. The excision alone is not always the complete treatment, because loose bodies are generally secondary to other diseases that can cause persistent symptoms with the ri...

Multiple Immunofluorescence Imaging Analysis Reveals Differential Expression of Disialo...
https://doi.org/10.1177/10935266211048733
Pediatric and Developmental Pathology : the Official Jour... Nishimaki H, Nakanishi Y et. al.

Oct 23rd, 2021 - Peripheral neuroblastic tumors (pNTs) are the most common childhood extracranial solid tumors. There are several therapeutic strategies targeting disialoganglioside GD2. Disialoganglioside GD3 has become a potential target. However, the mechanism by which pNTs express GD3 and GD2 remains unclear. We investigated the combined expression status of GD3 and GD2 in pNTs and delineated their clinicop...

Cerebral Palsy and the Study of Brain Activity During Motor Tasks
https://clinicaltrials.gov/ct2/show/NCT01829724

Oct 22nd, 2021 - Objective Neural imaging during functional tasks has become more portable and accessible than magnetic resonance imaging (MRI) by utilizing non-invasive near-infrared spectroscopy (NIRS) as a means to isolate areas of brain activity by measuring blood flow dynamics and electroencephalography (EEG) to measure electrical activity on the cortical surface. Although use of these technologies for ass...

Pituitary Disease and Pregnancy
https://emedicine.medscape.com/article/127650-print

Oct 22nd, 2021 - The pituitary gland generally undergoes an increase in size during pregnancy, which is mainly due to an increase in blood supply, as it is a highly vascular organ. Some of the volume increase may also occur as a result of estrogen-mediated hyperprolactinemia caused by lactotroph hyperplasia. Despite the increase in size of the pituitary gland during pregnancy, pituitary function usually remains...

Positron Emission Tomography of Infection and Vasculitis
https://clinicaltrials.gov/ct2/show/NCT01878721

Oct 22nd, 2021 - The purpose of this study is to evaluate the value of PET/CT in various inflammatory conditions caused by bacterial infection or vasculitis. Our aim is to: investigate whether FDG (18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose) PET/CT and 68Ga-(Gallium-68) citrate PET/CT enable the early and accurate detection of metastatic infection foci in Staphylococcus aureus bacteremia. study the usefu...

National Eye Institute Biorepository for Retinal Diseases
https://clinicaltrials.gov/ct2/show/NCT01496625

Oct 22nd, 2021 - This protocol establishes a clinical database and biospecimen repository for potential use in subsequent research projects approved by the NIH IRB, such as the identification of novel factors relevant to the pathogenesis, progression, and response to treatment of a variety of retinal conditions, particularly age-related macular degeneration (AMD) and diabetic retinopathy and their associated sy...

New Designed ePTFE Valved Conduits for Surgical Reconstruction of Right-ventricular Outflow Tract
https://clinicaltrials.gov/ct2/show/NCT04152967

Oct 22nd, 2021 - Valved conduits used for the reconstruction of right-ventricular outflow tract are applied in the surgical repair of complex congenital heart disease(CHD) such as pulmonary atresia(PA), truncus arteriosus, severe tetralogy of Fallot(TOF) for their significant roles in reducing pulmonary valve regurgitation and preserving right ventricle function. With a rising cases of complex CHD and patients ...

Natural History of KSHV-Associated Multicentric Castleman s Disease
https://clinicaltrials.gov/ct2/show/NCT04968288

Oct 22nd, 2021 - Background: Multicentric Castleman s disease (MCD) is a rare but lethal Kaposi s sarcoma-associated herpesvirus (KSHV) associated lymphoproliferative disorder with a historical median survival of 2 years. It occurs more often in HIV-infected individuals than those without HIV infection. The poor prognosis is not fully explained by the underlying HIV, as the HIV-negative cases appear to have lit...

In Vivo Characterization of Inflammation With Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging
https://clinicaltrials.gov/ct2/show/NCT02511028

Oct 22nd, 2021 - Objective The goals of this pilot study are to (1) demonstrate the safety of ferumoxytol, a United States Food and Drug Administration (FDA) approved drug used in the treatment of iron deficiency anemia, as a contrast agent for brain magnetic resonance imaging (MRI), as determined by a lack of long-term signal change in healthy volunteers (HV) and people with multiple sclerosis (MS); (2) determ...