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About 224,458 results

Retinal fluorescence imaging helps identify early functional changes
https://www.healio.com/news/ophthalmology/20220119/retinal-fluorescence-imaging-helps-identify-early-functional-changes

Jan 19th, 2022 - WAIKOLOA, Hawaii — Fluorescence imaging can be an important tool for early detection of retinal diseases, according to a presentation at Retina 2022. Rishi P. Singh, MD, said that technologies such as fundus autofluorescence (FAF), fluorescence lifetime imaging ophthalmoscopy (FLIO) and oxidized flavoprotein fluorescence (FPF) provide opportunities to identify cell dysfunction before it occurs....

Evolving Patterns of Metastasis in Renal Cell Carcinoma: Do We Need to Perform Routine Bone Imaging?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523177/
Journal of Kidney Cancer and VHL; Lin J

Oct 13th, 2021 - Advance diagnostic and treatment modalities have improved outcomes for renal cell carcinoma (RCC) patients, but the prognosis for those with metastatic disease (mRCC) remains poor. As given metastatic distribution is critical in guiding treatment decisions for mRCC patients, we evaluated evolving metastatic patterns to assess if our current practice standards effectively address patient needs.

Microvascular changes in the recurrent cystoid macular edema secondary to posterior non...
https://doi.org/10.1007/s10792-022-02327-0 10.1080/09273948.2016.1196713 10.1016/j.ajo.2018.02.019 10.4103/0301-4738.58470 10.1007/s40123-014-0023-x 10.1016/j.ophtha.2006.03.027 10.18240/ijo.2019.07.23 10.1159/000081203 10.1080/09273940802187466 10.1076/ocii.11.1.29.15582 10.1007/s10792-013-9822-7 10.1016/j.preteyeres.2017.04.005 10.1517/14656566.2011.571209 10.1186/s13063-020-4066-0 10.1097/IAE.0000000000000515 10.1111/ceo.13694 10.3310/hta21680 10.4274/tjo.galenos.2019.81594 10.1186/s12348-018-0148-5 10.1001/archophthalmol.2010.339 10.3109/09273948.2016.1160130 10.1089/jop.2016.0139 10.2147/OPTH.S84207 10.18240/ijo.2019.10.11 10.1136/bmjopen-2016-012799 10.1364/OE.20.004710 10.1111/ceo.13470 10.1016/j.ophtha.2003.08.037 10.1136/bjo.80.4.332 10.1038/eye.2016.133 10.1080/09273940701244509 10.1159/000336676 10.1136/bmj.1.5292.1579 10.1136/bjo.82.6.704 10.1016/j.ajo.2017.03.001 10.1007/s10067-016-3426-3 10.1007/s10067-016-3480-x 10.1007/s10067-016-3527-z 10.1007/s10067-016-3506-4 10.1038/eye.2016.115 10.1097/ICU.0000000000000210 10.1016/j.ajo.2016.04.020 10.1159/000368987 10.3109/09273948.2015.1132738 10.2147/OPTH.S40268 10.1038/eye.2001.5 10.1001/archopht.1978.03910060294024 10.2147/OPTH.S4033 10.4103/tjo.tjo_31_17 10.1007/s10792-019-01080-1 10.1186/s12348-019-0176-9 10.1136/bjophthalmol-2018-313078 10.1177/2515841420917781 10.4103/JOCO.JOCO_107_20 10.1186/s12348-019-0190-y 10.1097/IAE.0000000000001418 10.1007/s00417-018-4057-y 10.1016/j.ajo.2016.08.035 10.3390/jcm9124087 10.1007/s00592-017-0996-8
International Ophthalmology; Albano V, Guerriero S et. al.

May 23rd, 2022 - Posterior uveitis represents the second most frequent type of uveitis (15-30% of all uveitis). Noninfectious posterior uveitis complicated with secondary cystoid macular edema (CME) affects the visual prognosis negatively. The objective of the current study is to detect possible microvascular changes causing relapsing uveitis-related CME using optical coherence tomography angiography (OCTA). Th...

MRI EVALUATION OF PERIVASCULAR SPACE ABNORMALITIES IN NEUROMYELITIS OPTICA.
https://doi.org/10.1002/ana.26419
Annals of Neurology; Cacciaguerra L, Carotenuto A et. al.

May 22nd, 2022 - Astrocytes outline the perivascular space (PVS) and regulate fluids exchange through the aquaporin-4 water channel. Since neuromyelitis optica is an autoimmune astrocytopathy targeting aquaporin-4, we hypothesize that it could be associatied with PVS abnormalities. Thirty-four patients and 46 age- and sex-matched healthy controls from two independent cohorts (exploratory- and validation-dataset...

Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and ...
https://doi.org/10.1038/s41416-022-01839-x 10.1038/nrgastro.2011.20 10.1053/j.gastro.2013.10.013 10.1038/nrgastro.2016.51 10.1038/s41575-020-0310-z 10.1016/S0140-6736(13)61903-0 10.1056/NEJMoa1910836 10.1056/NEJMoa1606774 10.1001/jamaoncol.2020.0930 10.1001/jamaoncol.2020.2814 10.1016/j.cell.2014.12.021 10.1038/nm.4438 10.1016/j.stem.2016.04.003 10.1038/s41467-018-05190-9 10.1016/j.cell.2017.11.010 10.1016/j.cell.2015.03.053 10.1016/j.stem.2018.09.016 10.1016/j.canlet.2021.06.007 10.1186/s12885-018-4238-4 10.1080/2162402X.2020.1845424 10.1016/j.cell.2018.07.009 10.1016/j.celrep.2019.03.088 10.1016/j.celrep.2018.07.001 10.1053/j.gastro.2017.10.043 10.1053/j.gastro.2017.06.017 10.1158/2326-6066.CIR-21-0058 10.1038/nprot.2008.211 10.1093/nar/gkn923 10.1016/S0973-6883(11)60110-2 10.1007/s10620-014-3472-0 10.1002/hep.28493 10.1084/jem.190.12.1879 10.1002/jcp.27782 10.1038/s41577-018-0044-0 10.3389/fonc.2019.00989
British Journal of Cancer; Zhou G, Lieshout R et. al.

May 22nd, 2022 - Immunotherapy with immune checkpoint inhibitors (ICIs) is being explored to improve cholangiocarcinoma (CCA) therapy. However, it remains difficult to predict which ICI will be effective for individual patients. Therefore, the aim of this study is to develop a co-culture method with patient-derived CCA organoids and immune cells, which could represent anti-cancer immunity in vitro. CCA organoid...

Mechanistic Insights into Tricuspid Regurgitation Secondary to Pulmonary Arterial Hyper...
https://doi.org/10.1016/j.amjcard.2022.04.010
The American Journal of Cardiology; Kassis N, Layoun H et. al.

May 22nd, 2022 - The simultaneous presence of pulmonary arterial hypertension (PAH) and secondary tricuspid regurgitation (STR) portends particularly poor outcomes. However, not all patients with PAH develop significant STR, and the mechanisms and clinical implications underlying this phenomenon remain unclear. We sought to describe the functional, anatomic, hemodynamic, and clinical characteristics of patients...

Defining milestones for the study of remyelination using the cuprizone mouse model: How...
https://doi.org/10.1016/j.msard.2022.103886
Multiple Sclerosis and Related Disorders; Palavra F, Viana SD et. al.

May 22nd, 2022 - Cuprizone (CPZ) is a copper chelator used to produce a reversible oligodendrocytopathy in animals, which has some similarities to the pathology found in human multiple sclerosis (MS). This model is attractive to study remyelination. To demonstrate that a two-week period after cessation of CPZ exposure is sufficient to establish changes compatible with remyelination, without accompanying behavio...

Variability and concordance of sulcal patterns in the orbitofrontal cortex: A twin study.
https://doi.org/10.1016/j.pscychresns.2022.111492
Psychiatry Research. Neuroimaging; Troiani V, Snyder W et. al.

May 22nd, 2022 - Sulcogyral patterns have been identified in the orbitofrontal cortex (OFC) based on the continuity of the medial and lateral orbital sulci. Pattern types are named according to their frequency in the population, with Type I present in ∼60%, Type II in ∼25%, Type III in ∼10%, and Type IV in ∼5%. Previous work has demonstrated that psychiatric conditions with high estimated heritability (e.g. sch...

Computer-Aided Color Parameter Imaging of Contrast-Enhanced Ultrasound Evaluates Hepato...
https://doi.org/10.1016/j.ultrasmedbio.2022.04.002
Ultrasound in Medicine & Biology; Wang H, Guo W et. al.

May 22nd, 2022 - Computer-aided color parameter imaging (CPI) is a novel technique for contrast-enhanced ultrasound (CEUS) that can highlight hemodynamic features of focal lesions. The purpose of the study was to investigate the role of CPI in evaluation of hepatocellular carcinoma (HCC) hemodynamic features and prognosis after radiofrequency ablation (RFA). One hundred twenty-one patients with HCC underwent CE...

Fast T2-weighted liver MRI: Image quality and solid focal lesions conspicuity using a d...
https://doi.org/10.1016/j.diii.2022.05.001
Diagnostic and Interventional Imaging; Mulé S, Kharrat R et. al.

May 22nd, 2022 - Acceleration of MRI acquisitions and especially of T2-weighted sequences is essential to reduce the duration of MRI examinations but also kinetic artifacts in liver imaging. The purpose of this study was to compare the acquisition time and the image quality of a single-shot fat-suppressed turbo spin-echo (TSE) T2-weighted sequence with deep learning reconstruction (HASTEDL) with that of a fat-s...

Optical biopsy for esophageal squamous cell neoplasia by using endocytoscopy.
https://doi.org/10.1186/s12876-022-02335-5 10.1111/jgh.12477 10.1038/ajg.2014.94 10.1055/s-0035-1569644 10.1055/s-2006-944667 10.1111/j.1442-2050.2011.01241.x 10.1136/gut.47.2.251 10.1007/s10388-016-0551-7 10.1136/gut.51.1.130 10.1016/j.gie.2005.09.027 10.1055/s-0032-1325932 10.1111/den.12601 10.1055/a-1068-9228 10.1053/j.gastro.2016.07.040 10.1038/s41598-020-76309-6 10.1159/000506930 10.21037/tgh.2019.11.12 10.1002/1097-0142(19950915)76:6<928::AID-CNCR2820760604>3.0.CO;2-5 10.1186/1471-230X-14-141 10.1111/j.1440-1746.2009.06032.x 10.1097/CM9.0000000000000623 10.1016/j.gie.2018.07.037 10.1016/j.gie.2018.11.011 10.1053/j.gastro.2018.06.037 10.1053/j.gastro.2016.04.004 10.1055/s-0042-113609 10.1007/s10388-018-0651-7
BMC Gastroenterology; Shimoda Y, Shimizu Y et. al.

May 22nd, 2022 - Endocytoscopy (ECS) enables microscopic observation in vivo for the gastrointestinal mucosa; however, there has been no prospective study in which the diagnostic accuracy of ECS for lesions that have not yet undergone histological diagnosis was evaluated. We conducted a surveillance study for patients in a high-risk group of esophageal squamous cell carcinoma (ESCC) and evaluated the in vivo hi...

Atraumatic splenic rupture in a child with COVID 19.
https://doi.org/10.1186/s12887-022-03353-8 10.1016/j.biopha.2020.110195 10.3201/eid2608.201161 10.1016/j.clinpr.2020.100042 10.1186/s12893-020-00887-5 10.1016/S0025-6196(12)60835-0 10.1016/j.epsc.2020.101680 10.12659/AJCR.893919 10.1542/peds.2006-3071 10.1002/bjs.6737 10.1016/j.ijid.2013.10.022 10.1155/2021/5553619 10.1186/1752-1947-8-396 10.1002/path.1560 10.3760/cma.j.cn112151-2020041-00278 10.12659/AJCR.883739 10.1136/bmj.m1985 10.1001/jama.2020.10369 10.1093/jscr/rjaa337 10.1136/bmj.g1864 10.1007/s10353-018-0545-x 10.1016/j.injury.2006.07.018
BMC Pediatrics; Bakalli I, Biqiku M et. al.

May 22nd, 2022 - The majority of children with COVID-19 have only minor symptoms or none at all. COVID-19, on the other hand, can cause serious illness in some children, necessitating hospitalization, intensive care, and invasive ventilation. Many studies have revealed that SARS-CoV-2 affects not only the respiratory system, but also other vital organs in the body. We report here a child with an atraumatic sple...

Temporosylvian arachnoid cysts in children. Part 2: Postoperative neuropsychological an...
https://doi.org/10.3171/2021.11.PEDS21207
Journal of Neurosurgery. Pediatrics; Cuny ML, Piolino P et. al.

May 21st, 2022 - The authors' objective was to study clinical, imaging, and neuropsychological changes in children who underwent surgery for a temporal arachnoid cyst (TAC). Thirty-four children were prospectively assessed similarly at diagnosis and postoperatively (mean 14 months) with clinic visits, images, cognitive tests, and parental questionnaires on mood/behavior and executive functions. The scores were ...

Compactness index: a radiosurgery outcome predictor for patients with unruptured brain ...
https://doi.org/10.3171/2022.4.JNS212369
Journal of Neurosurgery; Huang PW, Peng SJ et. al.

May 21st, 2022 - The goal of the study was to define and quantify brain arteriovenous malformation (bAVM) compactness and to assess its effect on outcomes after Gamma Knife radiosurgery (GKRS) for unruptured bAVMs. Unsupervised machine learning with fuzzy c-means clustering was used to differentiate the tissue constituents of bAVMs on T2-weighted MR images. The percentages of vessel, brain, and CSF were quantif...

Accurate Preoperative Identification of Motor Speech Area as Termination of Arcuate Fas...
https://doi.org/10.1016/j.wneu.2022.05.041
World Neurosurgery; Koike T, Tanaka S et. al.

May 21st, 2022 - Tractography is one way to predict the distribution of cortical functional domains preoperatively. Diffusion tensor tractography (DTT) is commonly used in clinical practice but is known to have limitations in delineating crossed fibers, which can be overcome by q-ball imaging tractography (QBT). In this study, we aimed to compare the reliability of these two methods, based on the spatial correl...

Baseline Total Metabolic Tumor Volume is Prognostic for Refractoriness to Immunochemoth...
https://doi.org/10.1016/j.clml.2022.04.010
Clinical Lymphoma, Myeloma & Leukemia; Ruiz IC, Martelli M et. al.

May 21st, 2022 - A good response to initial therapy is key to maximizing survival in patients with diffuse large B-cell lymphoma (DLBCL), but patients with chemorefractory disease and early progression have poor outcomes. Data from the GOYA study in patients with DLBCL who received first-line rituximab or obinutuzumab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) were analyzed. Positron...

Iron-sensitive MR imaging of the primary motor cortex to differentiate hereditary spast...
https://doi.org/10.1007/s00330-022-08865-6 10.1016/S1474-4422(19)30235-2 10.1007/s10072-020-04981-7 10.1007/s11910-021-01099-x 10.1007/s12311-016-0803-z 10.1111/j.1365-2990.2004.00587.x 10.1016/S1474-4422(08)70258-8 10.1136/jnnp.37.1.8 10.1016/0303-8467(92)90010-Z 10.1001/archneurpsyc.1956.02330200038005 10.1007/s004010000255 10.1212/WNL.55.1.89 10.1055/s-2001-15265 10.1136/jnnp.44.10.871 10.1001/archneurol.2009.19 10.3390/brainsci11050611 10.3174/ajnr.A2043 10.1016/j.expneurol.2011.12.024 10.1371/journal.pone.0035241 10.3174/ajnr.A4562 10.1016/j.nicl.2016.04.011 10.3174/ajnr.A5423 10.1016/j.nicl.2019.101934 10.1111/j.1468-1331.2010.02951.x 10.1016/S0140-6736(83)92879-9 10.1212/01.wnl.0000228242.53336.90 10.1136/jnnp-2019-322541 10.1080/146608200300079536 10.1016/S0022-510X(99)00210-5 10.2307/2529310 10.1080/14660820410021267 10.1212/01.wnl.0000200962.94777.71 10.3390/brainsci11050578 10.3390/brainsci11030403 10.1007/s00401-013-1115-8 10.1007/s00401-011-0916-x 10.1148/radiol.14141715 10.3389/fneur.2018.01117 10.1007/s00415-015-7791-7 10.1212/01.WNL.0000058901.75728.4E 10.1016/S1474-4422(11)70015-1 10.3174/ajnr.A2067 10.1093/brain/115.2.495 10.1007/s00401-003-0687-0 10.1007/s00401-007-0234-5 10.1001/archneur.1981.00510100058008 10.1111/j.1440-1789.1997.tb00042.x 10.1016/j.nicl.2017.10.024 10.1080/21678421.2020.1837173 10.1136/jnnp.2009.201103 10.1016/j.jns.2009.09.025 10.3389/fneur.2018.00981 10.1002/ana.20652 10.1001/jama.2014.14604 10.1186/1471-2350-14-118 10.1002/ana.25263 10.3389/fgene.2019.00434 10.1212/01.wnl.0000338530.77394.60 10.1002/ana.23641
European Radiology; Cosottini M, Donatelli G et. al.

May 21st, 2022 - Hereditary spastic paraplegia (HSP) is a group of genetic neurodegenerative diseases characterised by upper motor neuron (UMN) impairment of the lower limbs. The differential diagnosis with primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS) can be challenging. As microglial iron accumulation was reported in the primary motor cortex (PMC) of ALS cases, here we assessed the r...

Multimodal Brain MRI of Deep Gray Matter Changes Associated With Inflammatory Bowel Dis...
https://doi.org/10.1093/ibd/izac089
Inflammatory Bowel Diseases; Goodyear BG, Heidari F et. al.

May 21st, 2022 - Behavioral symptoms, including mood disorders, substantially impact the quality of life of patients with inflammatory bowel disease (IBD), even when clinical remission is achieved. Here, we used multimodal magnetic resonance imaging (MRI) to determine if IBD is associated with changes in the structure and function of deep gray matter brain regions that regulate and integrate emotional, cognitiv...

POLYPOIDAL CHOROIDAL NEOVASCULARIZATION VERSUS TYPE 1 CHOROIDAL NEOVASCULARIZATION IN A...
https://doi.org/10.1097/IAE.0000000000003439
Retina (Philadelphia, Pa.); Serra R, Coscas F et. al.

May 21st, 2022 - To compare quantitative optical coherence tomography angiography parameters between polypoidal choroidal neovascularizations (PCNVs) and Type 1 choroidal neovascularizations (CNVs) in patients with age-related macular degeneration. PCNV and Type 1 CNV lesions were retrospectively recruited in a cohort of patients with age-related macular degeneration. All the patients underwent a comprehensive ...

Pediatric Osteosarcoma: Correlation of Imaging Findings with Histopathologic Features, ...
https://doi.org/10.1148/rg.210171
Radiographics : a Review Publication of the Radiological ... Nguyen JC, Baghdadi S et. al.

May 21st, 2022 - Osteosarcoma is the most common primary bone sarcoma in children. Imaging plays a pivotal role in diagnostic workup, surgical planning, and follow-up monitoring for possible disease relapse. Survival depends on multiple factors, including presence or absence of metastatic disease, chemotherapy response, and surgical margins. At diagnosis, radiography and anatomic MRI are used to characterize th...