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About 268,205 results

Retinal fluorescence imaging helps identify early functional changes
https://www.healio.com/news/ophthalmology/20220119/retinal-fluorescence-imaging-helps-identify-early-functional-changes

Jan 19th, 2022 - WAIKOLOA, Hawaii — Fluorescence imaging can be an important tool for early detection of retinal diseases, according to a presentation at Retina 2022. Rishi P. Singh, MD, said that technologies such as fundus autofluorescence (FAF), fluorescence lifetime imaging ophthalmoscopy (FLIO) and oxidized flavoprotein fluorescence (FPF) provide opportunities to identify cell dysfunction before it occurs....

Consensus group provides imaging criteria for assessment of geographic atrophy
https://www.healio.com/news/ophthalmology/20220119/consensus-group-provides-imaging-criteria-for-assessment-of-geographic-atrophy

Jan 19th, 2022 - WAIKOLOA, Hawaii — In a series of published reports, the Classification of Atrophy Meeting group provided consensus-based imaging parameters for multimodal assessment of geographic atrophy. The group also revised the definitions of specific features of geographic atrophy (GA) and identified features that may predict progression to atrophy. “In the first CAM report, we described the imaging moda...

Natural History and Development of Spondyloarthritis
https://clinicaltrials.gov/ct2/show/NCT01422694

Jan 31st, 2023 - The purpose of this protocol is to study the natural history of spondyloarthritis (SpA) in children and adults. Spondyloarthritis encompasses a spectrum of immune-mediated inflammatory diseases that exhibit overlapping features, but differ from other types of inflammatory arthritis in genetic predisposition, pathogenesis, and outcome. Ankylosing spondylitis (AS), the most common form of SpA, fr...

2019 Update of the American College of Rheumatology/Spondylitis Association of America/...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764882
Arthritis & Rheumatology (Hoboken, N.J.); Ward MM, Deodhar A et. al.

Aug 23rd, 2019 - To update evidence-based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA). We conducted updated systematic literature reviews for 20 clinical questions on pharmacologic treatment addressed in the 2015 guidelines, and for 26 new questions on pharmacologic treatment, treat-to-target strategy, and use of imaging. New q...

Mifepristone induced liver injury in a patient with Cushing syndrome: a case report and...
https://doi.org/10.1186/s13256-022-03696-x
Journal of Medical Case Reports; Ault TA, Braxton DR et. al.

Feb 4th, 2023 - Mifepristone, also known as RU-486, is an anti-progestational steroid with similar chemical structure to anabolic steroids. Given as a single dose in conjunction with misoprostol, mifepristone is used to induce medical abortion. Mifepristone administered chronically at a higher dose is also approved for the management of hypercortisolism. There have been only 2 reported cases of mifepristone as...

Quantitative Characterization of Intertumor Heterogeneity of Primary Cardiac Diffuse La...
https://doi.org/10.1161/CIRCIMAGING.122.014884
Circulation. Cardiovascular Imaging; Ni L, Li C et. al.

Feb 4th, 2023 - Quantitative Characterization of Intertumor Heterogeneity of Primary Cardiac Diffuse Large B-Cell Lymphoma Using Cardiac Magnetic Resonance.|2023|Ni L,Li C,Du Y,Sun Z,Fan G,|

Identification of circulating microRNA patterns in patients in psoriasis and psoriatic ...
https://doi.org/10.1093/rheumatology/kead059
Rheumatology (Oxford, England); Haschka J, Simon D et. al.

Feb 4th, 2023 - MicroRNAs (miRNAs) are small non-coding RNAs that control gene expression. Specific intra- and extracellular miRNA signatures have been identified in various diseases. Whether certain miRNA signatures are associated with psoriasis (PsO) and psoriatic arthritis (PsA) is currently unknown. We aimed to search for circulating miRNA signatures associated with PsO and PsA patients. Expression of miRN...

Machine learning identifies pathophysiologically and prognostically informative phenoty...
https://doi.org/10.1093/ehjci/jead013
European Heart Journal. Cardiovascular Imaging; Trenkwalder T, Lachmann M et. al.

Feb 4th, 2023 - Patients with mitral regurgitation (MR) present with considerable heterogeneity in cardiac damage depending on underlying aetiology, disease progression, and comorbidities. This study aims to capture their cardiopulmonary complexity by employing a machine-learning (ML)-based phenotyping approach. Data were obtained from 1426 patients undergoing mitral valve transcatheter edge-to-edge repair (MV...

18F-FDG PET/CT Imaging Post Heart Transplantation Depicts High Accumulation at Sites of...
https://doi.org/10.1097/RLU.0000000000004580
Clinical Nuclear Medicine; Toyama Y, Otani M et. al.

Feb 4th, 2023 - A 37-year-old man with previous heart transplantation for dilated cardiomyopathy underwent screening for malignancy under posttransplantation immunosuppression. 18F-FDG PET/CT revealed uptake in 2 peritoneal sites of the pericardium that corresponded to the insertion sites of a left ventricular assist device that was used before transplantation. Additional abnormal uptake in the right axillary ...

Neurophysiology of Juvenile and Progressive Myoclonic Epilepsy.
https://doi.org/10.1097/WNP.0000000000000913
Journal of Clinical Neurophysiology : Official Publicatio... Acharya JN, Acharya VJ

Feb 4th, 2023 - Myoclonus can be epileptic or nonepileptic. Epileptic myoclonus has been defined in clinical, neurophysiological, and neuroanatomical terms. Juvenile myoclonic epilepsy (JME) is typically considered to be an adolescent-onset idiopathic generalized epilepsy with a combination of myoclonic, generalized tonic-clonic, and absence seizures and normal cognitive status that responds well to anti-seizu...

Incremental Effect of Mitral Regurgitation on Left Atrial Dysfunction and Atrioventricu...
https://doi.org/10.1002/jmri.28604
Journal of Magnetic Resonance Imaging : JMRI; Tang SS, Shi R et. al.

Feb 4th, 2023 - Mitral regurgitation may occur when hypertension causes left ventricular (LV) and left atrial (LA) remodeling. However, its role in LA function in hypertensive patients remains unclear. To explore how mitral regurgitation affects LA function in hypertension and to investigate atrioventricular interaction in hypertensive patients with mitral regurgitation. Retrospective. A total of 193 hypertens...

Angiopep-2 Modified Exosomes Load Rifampicin with Potential for Treating Central Nervou...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888470
International Journal of Nanomedicine; Li H, Ding Y et. al.

Feb 4th, 2023 - Central nervous system tuberculosis (CNS-TB) is the most devastating form of extrapulmonary tuberculosis. Rifampin (RIF) is a first-line antimicrobial agent with potent bactericidal action. Nonetheless, the blood-brain barrier (BBB) limits the therapeutic effects on CNS-TB. Exosomes, however, can facilitate drug movements across the BBB. In addition, exosomes show high biocompatibility and drug...

Primary squamous cell carcinoma of the ovary accompanied by transition of a mucinous bo...
https://doi.org/10.1177/03000605221098177
The Journal of International Medical Research; Bak S, Hong JY et. al.

Feb 4th, 2023 - This report describes a woman with a rare primary squamous cell carcinoma of the ovary accompanied by transition of a mucinous borderline ovarian tumor. A woman in her late 40s was referred for abdominal discomfort, which worsened during defecation. Pelvic magnetic resonance imaging showed a multiloculated cystic lesion in the left adnexa measuring approximately 7.5 × 9.5 × 7.0 cm. An intraoper...

Camptothecin improves sorafenib sensitivity by inhibiting Nrf2‑ARE pathway in hepatocel...
https://doi.org/10.3892/or.2023.8492
Oncology Reports; Sun L, Wang H et. al.

Feb 4th, 2023 - Sorafenib is a targeted drug for hepatocellular carcinoma (HCC), however, its efficacy is limited. Nuclear factor erythroid 2‑related factor 2 (Nrf2) contributes to sorafenib resistance. The present study investigated camptothecin (CPT) as a Nrf2 inhibitor to sensitize HCC to sorafenib. The effect of CPT on sorafenib sensitivity in HCC was assessed in vivo using H22 mice model (n=32) and VX2 ra...

A Comprehensive Review of Dilated Cardiomyopathy in Pre-clinical Animal Models in Addit...
https://doi.org/10.2174/1871529X23666230123122808
Cardiovascular & Hematological Disorders Drug Targets; Kaur N, Sharma RK et. al.

Feb 4th, 2023 - Dilated cardiomyopathy (DCM) is distinguished by ventricular chamber expansion, systolic dysfunction, and normal left ventricular (LV) wall thickness, and is mainly caused due to genetic or environmental factors; however, its aetiology is undetermined in the majority of patients. The focus of this work is on pathogenesis, small animal models, as well as the herbal medicinal approach, and the mo...

Intraoperative Bronchoscopic Inspection Facilitates Thoracoscopic Repair of Esophageal ...
https://doi.org/10.1089/lap.2022.0141
Journal of Laparoendoscopic & Advanced Surgical Technique... Koga H, Miyano G et. al.

Feb 4th, 2023 - Aim: The value of intraoperative bronchoscopic inspection (IBI) for accurate confirmation of the location and distance between the distal tracheoesophageal fistula (TEF) and the proximal blind end of the esophagus (GAP) was evaluated in Type C esophageal atresia (EA)+TEF. Methods: IBI involved inserting the tip of a bronchoscope into the TEF and a nasogastric tube into the blind end of the EA a...

Heart Failure Risk Lingers Long After Chemotherapy, Regardless of Dose
https://www.medpagetoday.com/cardiology/chf/102955

Feb 3rd, 2023 - Anthracycline users with breast cancer or lymphoma had an upfront risk of congestive heart failure (CHF) that persisted during long-term follow-up in a population-based case-control study. The cumulative incidence of new-onset CHF was significantly higher for cancer patients treated with anthracyclines compared with healthy controls at every time point -- namely: Importantly, cancer patients re...

Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (pNFs)
https://clinicaltrials.gov/ct2/show/NCT02544022

Feb 3rd, 2023 - Background: Neurofibromatosis 1 (NF1) is a genetic disease with multiple clinical manifestations, including plexiform neurofibromas (pNFs) that can cause pain and may significantly impact daily functioning and quality of life (QOL). Patient-reported outcomes (PROs) are useful in trials for conditions that are disabling and chronic like NF1, where symptom reduction and improved functioning and Q...

Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations
https://clinicaltrials.gov/ct2/show/NCT03212274

Feb 3rd, 2023 - PRIMARY OBJECTIVE: I. To estimate the overall response rates of olaparib in subjects with recurrent/progressive IDH1/2-mutant solid tumors, who will be recruited to 3 cohorts: a. glioma, b. cholangiocarcinoma, c. other solid malignant tumors. SECONDARY OBJECTIVES: I. To estimate the distribution of progression free survival (PFS) of olaparib in adults with recurrent/progressive IDH1/2-mutant gl...

123 I-FP-CIT SPECT Prescriptions for Parkinsonian Syndromes
https://clinicaltrials.gov/ct2/show/NCT05698784

Feb 3rd, 2023 - the investigators included 723 patients in this retrospective study between February 2009 and May 2019, in the nuclear medicine Department of Avicenne University Hospital. No patients were excluded. Demographic, clinical, brain imaging, and 123I-FP-CIT SPECT data were collected from medical records. The study was conducted in accordance with the Declaration of Helsinki, and approved by the Inst...