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About 605,070 results

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630469
Journal of Hepatocellular Carcinoma; Deldar Abad Paskeh M, Mirzaei S et. al.

Dec 4th, 2021 - Liver cancers cause a high rate of death worldwide and hepatocellular carcinoma (HCC) is considered as the most common primary liver cancer. HCC remains a challenging disease to treat. Wnt/β-catenin signaling pathway is considered a tumor-promoting factor in various cancers; hence, the present review focused on the role of Wnt signaling in HCC, and its association with progression and therapy r...

Clinical Outcomes of COVID-19 and Impact on Disease Course in Patients with Inflammator...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632463
Canadian Journal of Gastroenterology & Hepatology; Wetwittayakhlang P, Albader F et. al.

Dec 4th, 2021 - The impact of COVID-19 has been of great concern in patients with inflammatory bowel disease (IBD) worldwide, including an increased risk of severe outcomes and/or possible flare of IBD. This study aims to evaluate prevalence, outcomes, the impact of COVID-19 in patients with IBD, and risk factors associated with severe COVID-19 or flare of IBD activity. A consecutive cohort of IBD patients who...

Liver Transplantation for intrahepatic cholangiocarcinoma: ready for prime time?
https://doi.org/10.1002/hep.32258
Hepatology (Baltimore, Md.); Sapisochin G, Ivanics T et. al.

Dec 4th, 2021 - Cholangiocarcinoma (CCA) represents the second most common primary liver malignancy after hepatocellular carcinoma and has risen in incidence globally in the past decades. Intrahepatic cholangiocarcinoma (iCCA) comprises 20% of all CCAs, with the rest being extrahepatic (including perihilar [pCCA] and distal CCA). Though long representing an absolute contraindication for liver transplantation (...

Health-related quality of life, obesity, fragmented sleep, fatigue, and psychosocial pr...
https://doi.org/10.1002/pon.5862
Psycho-oncology Klages KL, Berlin KS et. al.

Dec 4th, 2021 - Youth with craniopharyngioma experience weight gain, fragmented sleep, excessive daytime sleepiness (EDS), fatigue, and psychosocial problems that negatively impact their overall health-related quality of life (HRQoL). Greater hypothalamic tumor involvement (HI) may be associated with higher rates or severity of these impairments; however, the direct and indirect impact of HI on the physical an...

Retrospective evaluation of an observational cohort by the Central and Eastern Europe N...
https://doi.org/10.1111/hiv.13214
HIV Medicine; Lakatos B, Kowalska J et. al.

Dec 4th, 2021 - The aim of this international multicentre study was to review potential drug-drug interactions (DDIs) for real-life coadministration of combination antiretroviral therapy (cART) and coronavirus disease 2019 (COVID-19)-specific medications. The Euroguidelines in Central and Eastern Europe Network Group initiated a retrospective, observational cohort study of HIV-positive patients diagnosed with ...

Efficiency of high cumulative cisplatin dose in high- and low-risk patients with locore...
https://doi.org/10.1002/cam4.4477
Cancer Medicine; Jiang YT, Chen KH et. al.

Dec 4th, 2021 - The optimal cumulative cisplatin dose (CCD) during radiation therapy for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients receiving induction chemotherapy (IC) plus CCRT remains controversial. This study aimed to explore the treatment efficiency of CCD for high-and low-risk patients with LA-NPC. Data from 472 LA-NPC patients diagnosed from 2014 to 2018 and treated with IC plus...

Impact of elexacaftor/tezacaftor/ivacaftor on vitamin D absorption in cystic fibrosis p...
https://doi.org/10.1002/ppul.25781
Pediatric Pulmonology; Wright BA, Ketchen NK et. al.

Dec 4th, 2021 - Cystic fibrosis (CF) is a multisystem disorder that results in the buildup of mucus in various organs. Ninety percent of CF patients are classified as pancreatic insufficient, leading to malabsorption of nutrients and fat-soluble vitamins without the assistance of exogenous pancreatic enzymes. This study was designed to determine if serum 25-hydroxyvitamin D concentrations were impacted by init...

Thematic Analysis of Coping Strategies Used by Parents of Children with Cleft Lip and P...
https://doi.org/10.1177/10556656211062839
The Cleft Palate-craniofacial Journal : Official Publicat... Aleman RM, Martinez MG

Dec 4th, 2021 - The aim of this study was to describe coping strategies used by parents of children with cleft palate with or without a cleft (CP ± L) during the early development of their children in El Salvador. Qualitative interviews were completed with 16 parents of children born with CP ± L who were 6 months to 6 years old. Parents were questioned about their emotions and coping during eight time periods:...

Phenotypic spectrum and long-term outcome of children with genetic early-infantile-onse...
https://doi.org/10.1684/epd.2021.1394
Epileptic Disorders : International Epilepsy Journal With... Hu C, Liu D et. al.

Dec 4th, 2021 - Developmental and epileptic encephalopathy (DEE) is characterized by refractory seizures, developmental delay or intellectual disability, which may be caused by gene mutation. In this study, we explored the clinical phenotype and long-term outcome in children with genetic early-infantile-onset DEEs. Next-generation sequencing was performed on 470 patients diagnosed with early-infantile-onset DE...

Platycodin D inhibits the malignant progression of papillary thyroid carcinoma by NF-κB...
https://doi.org/10.1002/ddr.21902
Drug Development Research; Deng B, Sun M

Dec 4th, 2021 - Papillary thyroid carcinoma (PTC) is the most common pathological type of thyroid cancer. Studies have shown that platycodin D has several pharmacological effects like anti-inflammatory, immunomodulatory, and anti-tumor effects, while the effect and mechanism of platycodin D on PTC are still unclear. This study was designed to investigate the effects of platycodin D on PTC by a series of in vit...

Targeting abundant survivin expression in liposarcoma: subtype dependent therapy respon...
https://doi.org/10.1007/s00432-021-03871-5 10.1038/nm0897-917 10.1097/SLA.0b013e3181928f2f 10.1038/ng.619 10.1016/j.prp.2017.02.009 10.1016/j.urology.2006.09.024 10.1016/j.yasu.2015.04.002 10.1016/j.soc.2016.05.007 10.1158/1078-0432.CCR-11-2820 10.1097/01.sla.0000234795.98607.00 10.1016/j.tranon.2017.05.007 10.18632/oncotarget.14207 10.3892/ol.2017.6999 10.3892/ol.2018.7755 10.1097/01.sla.0000141710.74073.0d 10.1002/cncr.26195 10.1158/1078-0432.CCR-11-2592 10.1007/s12013-014-0238-4 10.1002/pbc.24290 10.1093/annonc/mdr485 10.1002/med.21264 10.1186/s12885-017-3398-y 10.1007/s00432-014-1734-z 10.1007/BF02524350 10.1007/s11033-013-2650-z 10.1371/journal.pone.0065338 10.4161/cbt.6.4.3816 10.1007/s11864-017-0457-1 10.1200/JCO.2017.74.9598 10.1006/meth.2001.1262 10.1245/s10434-012-2834-0 10.1002/ijc.10450 10.1007/s13277-015-4050-6 10.1136/mp.56.4.198 10.1097/sla.0b013e3181b2468b 10.1002/1097-0142(19940815)74:4<1265::aid-cncr2820740414>3.0.co;2-x 10.1016/j.drudis.2017.05.009 10.1373/clinchem.2004.039149 10.1111/j.2042-7158.2012.01567.x 10.1038/bjc.2016.5 10.1038/s41598-017-11426-3 10.1242/jcs.223826 10.1001/jama.2013.281053 10.1016/j.bbrc.2012.07.103 10.1080/07357907.2016.1212205
Journal of Cancer Research and Clinical Oncology; Vay C, Schlünder PM et. al.

Dec 4th, 2021 - Liposarcoma (LPS) represent the largest group of malignant soft tissue tumours comprising a heterogeneous group of subtypes in which the degrees of chemoresistance and radiosensitivity strongly vary. Consequently, it is of utmost interest to establish novel therapeutic regimens based on molecular targets. Immunohistochemical staining of survivin was performed in tissue microarrays comprising 49...

Time to regain birth weight - a marker to predict the severity of retinopathy of premat...
https://doi.org/10.1186/s12887-021-03027-x 10.1016/j.jpeds.2012.12.038 10.1001/archophthalmol.2012.243 10.3345/kjp.2015.58.2.52 10.1016/S0140-6736(13)60178-6 10.1001/archopht.1996.01100140419009 10.1542/peds.112.5.1016 10.1073/pnas.101113998 10.1203/00006450-200112000-00017 10.1159/000087587 10.1038/70963 10.1093/humrep/13.5.1389 10.1203/00006450-199103000-00001 10.1016/0378-3782(86)90096-4 10.1203/01.PDR.0000155950.67503.BC 10.1016/j.clp.2013.02.004 10.3109/14767058.2013.764407 10.1001/archophthalmol.2009.244 10.1542/peds.2004-1309 10.1001/archopht.124.12.1711 10.1007/s00417-008-1012-3 10.1136/archdischild-2014-306816 10.1080/14767058.2017.1381902 10.1001/archopht.121.12.1684 10.1542/peds.2018-3061 10.21037/aes.2017.03.05 10.2223/JPED.1870 10.1067/mpa.2000.110342 10.1067/mpa.2003.S1091853102420150 10.1080/14767058.2021.1940937 10.1016/j.anpede.2020.05.016 10.3928/01913913-20190208-01 10.20471/acc.2020.59.03.03 10.1038/eye.2011.29 10.3980/j.issn.2222-3959.2015.06.23 10.1080/20469047.2019.1631588 10.1038/s41598-020-74600-0 10.1136/archdischild-2019-316976
BMC Pediatrics; Anvekar A, Athikarisamy S et. al.

Dec 4th, 2021 - Poor weight gain in the first few weeks of life has been studied as a predictor of retinopathy of prematurity (ROP). Our aim was to assess whether time taken to regain birthweight (BW) be used as an additional marker to identify infants with type 1 ROP. In this retrospective study, preterm infants (< 27 weeks gestational age at birth) born during the period from 1/1/2010-31/12/2015 at a tertiar...

Prevalence of potential mediators of artemisinin resistance in African isolates of Plas...
https://doi.org/10.1186/s12936-021-03987-6
Malaria Journal; Owoloye A, Olufemi M et. al.

Dec 4th, 2021 - The devastating public health impact of malaria has prompted the need for effective interventions. Malaria control gained traction after the introduction of artemisinin-based combination therapy (ACT). However, the emergence of artemisinin (ART) partial resistance in Southeast Asia and emerging reports of delayed parasite sensitivity to ACT in African parasites signal a gradual trend towards tr...

Inflammatory breast cancer, trimodal treatment, and mortality: Does where you live matter?
https://doi.org/10.1016/j.surg.2021.08.061
Surgery Relation T, Li Y et. al.

Dec 4th, 2021 - The objective of this study is to examine the associations among neighborhood socioeconomic status, trimodal treatment, and disease-specific mortality among inflammatory breast cancer patients using data from the Surveillance, Epidemiology, and End Results program. Patients diagnosed with inflammatory breast cancer (T4d) from 2010 to 2016 were identified in the Surveillance, Epidemiology, and E...

CCEDRRN COVID-19 Infection Score (CCIS): development and validation in a Canadian cohor...
https://doi.org/10.1136/bmjopen-2021-055832
BMJ Open; McRae AD, Hohl CM et. al.

Dec 4th, 2021 - To develop and validate a clinical risk score that can accurately quantify the probability of SARS-CoV-2 infection in patients presenting to an emergency department without the need for laboratory testing. Cohort study of participants in the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) registry. Regression models were fitted to predict a positive SARS-CoV-2 test resul...

Severe neonatal autoimmune thrombocytopenia secondary to maternal Evans syndrome.
https://doi.org/10.1136/bcr-2021-245695
BMJ Case Reports; Beryl S, Ross BJ et. al.

Dec 4th, 2021 - Evans syndrome is a rare and chronic autoimmune disease seen in both paediatric and adult age groups. We present a case of severe thrombocytopenia in a neonate born to a mother with Evans syndrome who showed no response to intravenous immunoglobulin therapy initially and improved after treatment with methylprednisolone.

Biodistribution and radiation dosimetry of intraperitoneally administered 124I-omburtam...
https://doi.org/10.2967/jnumed.121.262793
Journal of Nuclear Medicine : Official Publication, Socie... Grkovski M, Modak S et. al.

Dec 4th, 2021 - The aim of this study was to assess the pharmacokinetics, biodistribution, and radiation dosimetry of 124I-omburtamab administered intraperitoneally in patients with desmoplastic small round cell tumor (DSRCT). Methods: Eligible patients diagnosed with DSRCT with peritoneal involvement were enrolled in a phase I trial of intraperitoneal radioimmunotherapy with 131I-omburtamab (NCT01099644). Aft...

Repository corticotropin injection improves quality metrics in an observational study o...
https://doi.org/10.2217/nmt-2021-0030
Neurodegenerative Disease Management; Kaplan J, Miller T et. al.

Dec 4th, 2021 - Aim: To determine whether clinicians evaluate American Academy of Neurology (AAN) quality metrics for patients with multiple sclerosis (MS) relapse and whether repository corticotropin injection (RCI) improves clinical and patient-reported outcomes associated with these metrics at 2 and 6 months after treatment. Methods: A multicenter, prospective, observational registry evaluating patients rec...

Analysis of SIRT4 gene single-nucleotide polymorphisms in a Han Chinese population with...
https://doi.org/10.2217/bmm-2021-0363
Biomarkers in Medicine; Zhong Y, Shen C et. al.

Dec 4th, 2021 - Aim: We aimed to investigate the association of SIRT4 gene polymorphisms with the susceptibility and prognosis of dilated cardiomyopathy (DCM) in a Chinese population. Materials & methods: A total of 369 controls and 373 DCM patients were enrolled. Three tag single-nucleotide polymorphisms (rs2261612, rs2522138 and rs16950058) on SIRT4 were evaluated. Results: G carriers of rs2261612 were assoc...