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About 802,208 results

Take steps to manage pseudoexfoliation glaucoma in cataract surgery
https://www.healio.com/news/ophthalmology/20220119/take-steps-to-manage-pseudoexfoliation-glaucoma-in-cataract-surgery

Jan 19th, 2022 - WAIKOLOA, Hawaii — Keep the cornea in mind and protect the endothelium when managing pseudoexfoliation glaucoma during cataract surgery, a presenter said here. “Consider femto if at all possible to decrease the ultrasound and combine with angle surgery, but skip the implants to save the cornea,” Malik Y. Kahook, MD, said at Hawaiian Eye 2022. The second key is to target the angle first and earl...

How to avoid the perils of uveitis diagnostic management
https://www.healio.com/news/ophthalmology/20220116/how-to-avoid-the-perils-of-uveitis-diagnostic-management

Jan 16th, 2022 - WAIKOLOA, Hawaii — It is important for physicians to consider “the perils that dwell” in the diagnostic management of patients with uveitis, Steven Yeh, MD, said during a presentation at Hawaiian Eye 2022. “With these patients being very complex oftentimes, we really just don’t want to miss something,” Yeh said. To better identify “the pearls amongst the perils” in uveitis diagnosis, it is impo...

VIDEO: Lee explains how to identify NMOSD in patients with optic neuritis
https://www.healio.com/news/ophthalmology/20210521/video-lee-explains-how-to-identify-nmosd-in-patients-with-optic-neuritis

May 21st, 2021 - WAILEA, Hawaii — In this video from Hawaiian Eye 2021, Andrew G. Lee, MD, discusses the important questions ophthalmologists should ask patients with optic neuritis to identify neuromyelitis optica spectrum disorder.

A Study to Evaluate Subcutaneous Daratumumab in Combination With Standard Multiple Myeloma Treatment Regimens
https://clinicaltrials.gov/ct2/show/NCT03412565

Aug 12th, 2022 - The hypothesis is that the addition of daratumumab administered SC to standard MM regimens will improve responses compared to response data observed in completed phase 3 studies without daratumumab. Disease evaluations will include measurements of myeloma proteins, bone marrow examinations, skeletal surveys, assessment of extramedullary plasmacytomas, and measurements of serum calcium corrected...

Pfizer and Valneva Initiate Phase 3 Study of Lyme Disease Vaccine Candidate VLA15
https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-valneva-initiate-phase-3-study-lyme-disease
Pfizer Inc.

Aug 8th, 2022 - NEW YORK & SAINT-HERBLAIN, France--(BUSINESS WIRE)-- Pfizer Inc. (NYSE: PFE) and Valneva SE (Nasdaq: VALN; Euronext Paris: VLA) today announced the initiation of a Phase 3 clinical study, Vaccine Against Lyme for Outdoor Recreationists (VALOR) (NCT05477524), to investigate the efficacy, safety and immunogenicity of their investigational Lyme disease vaccine candidate, VLA15.

Major test of first possible Lyme vaccine in 20 years begins
https://apnews.com/article/science-health-ticks-73fab8e29f3e2243c2db5bc33b3265e1
Associated Press; Neergaard L, Lum S.

Aug 8th, 2022 - DUNCANSVILLE, Pa. (AP) — Researchers are seeking thousands of volunteers in the U.S. and Europe to test the first potential vaccine against Lyme disease in 20 years -- in hopes of better fighting the tick-borne threat.

Autonomic Dysfunction After COVID-19
https://www.jwatch.org/na55049/2022/06/22/autonomic-dysfunction-after-covid-19
NEJM Journal Watch; Krumholz HM.

Jun 22nd, 2022 - Patients who have had an infection with SARS-CoV-2 may report symptoms of poor exertional tolerance, tachycardia with minimal activity or positional change, and palpitations more than 4 weeks after the acute COVID-19 episode. The purported mechanism is dysregulation of the autonomic nervous system and may be associated with new-onset postural orthostatic tachycardia syndrome (POTS). To provide ...

Combined central and peripheral demyelination after COVID-19 vaccination
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116708/
Journal of Neurology; Coelho P, Paula A et. al.

May 18th, 2022 - Combined central and peripheral demyelination (CCPD) is a rare neurological entity that affects both the central and peripheral nervous system with demyelinating lesions [1, 2]. The pattern of involvement of the central nervous system (CNS) includes frequent bilateral optical neuritis, involvement of grey matter and occasional longitudinally extensive transverse myelitis (LETM) in the absence o...

Music appreciation phenotypes in patients with frontotemporal dementia: A pilot study.
https://doi.org/10.1002/gps.5793
International Journal of Geriatric Psychiatry; van 't Hooft JJ, Fieldhouse JLP et. al.

Aug 14th, 2022 - Frontotemporal dementia (FTD) can present with changes in music appreciation. Research has suggested a relationship of altered music appreciation phenotypes with typical socio-emotional changes. We aimed to determine the prevalence and severity of music appreciation phenotypes in FTD and study the relationship with emotion recognition capacities in order to examine whether they could serve as a...

Impact of sleep-disordered breathing on the management of children with Chiari malforma...
https://doi.org/10.1002/ppul.26113
Pediatric Pulmonology; Vagianou F, Khirani S et. al.

Aug 14th, 2022 - Children with Chiari Malformation type I (CM-I) have an increased risk of sleep apnea. The aim of the study was to describe the management of CM-I patients in relation to symptoms, magnetic resonance imaging (MRI) findings and sleep apnea syndrome (SAS). We performed a retrospective analysis of clinical charts of all 57 CM-I patients seen between September 2013 and April 2017. Forty-five patien...

X-linked mental retardation-hypotonic facies syndrome: Exome sequencing identifies nove...
https://doi.org/10.1002/mgg3.2034
Molecular Genetics & Genomic Medicine; Shakarami F, Jahani M et. al.

Aug 14th, 2022 - X-linked mental retardation-hypotonic facies syndrome-1 (MRXFH1), caused by a mutation in the ATRX gene, is a rare syndromic form of X-linked mental retardation (XLMR) that is mainly characterized by severe intellectual disability, dysmorphic facies, and skewed X-inactivation pattern in carrier women. In this study, due to the genetic heterogeneity of the disease, we performed exome sequencing ...

Further clinical delineation of microcephaly-capillary malformation syndrome.
https://doi.org/10.1002/ajmg.a.62936
American Journal of Medical Genetics. Part A; Postma JK, Zambonin JL et. al.

Aug 14th, 2022 - Microcephaly-Capillary Malformation syndrome (MIC-CAP) is a rare genetic disorder reported in 18 individuals to date. The clinical features typically include microcephaly, multiple cutaneous capillary malformations, seizures, neurologic impairment, and global developmental delay. Currently, there is little published information about the natural history and long-term outcomes for individuals wi...

Extraskeletal myxoid chondrosarcoma: Clinicopathological features and outcomes from the...
https://doi.org/10.1002/jso.27062
Journal of Surgical Oncology; Gusho CA, King D et. al.

Aug 14th, 2022 - This investigation described clinicopathological features and outcomes of extraskeletal myxoid chondrosarcoma (EMC) patients. EMC patients were identified from the United States Sarcoma Collaborative database between 2000 and 2016. Overall survival (OS) and recurrence-free survival (RFS) were calculated, and prognostic factors were analyzed. Sixty individuals with a mean age of 55 years were in...

Current Potential for Clinical Optimization of Social Cognition Assessment for Frontote...
https://doi.org/10.1007/s11065-022-09554-3
Neuropsychology Review; Van den Stock J, Bertoux M et. al.

Aug 14th, 2022 - Dodich and colleagues recently reviewed the evidence supporting clinical use of social cognition assessment in behavioral variant frontotemporal dementia (Dodich et al., 2021). Here, we comment on their methods and present an initiative to address some of the limitations that emerged from their study. In particular, we established the social cognition workgroup within the Neuropsychiatric Inter...

Comparative analysis of complement C3 and C4 serum levels for outcome prediction in ANC...
https://doi.org/10.1007/s40620-022-01414-w
Journal of Nephrology; Tampe D, Baier E et. al.

Aug 14th, 2022 - The activation of the complement system contributes essentially to the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis. We here aimed to directly compare levels of C3 and C4 for outcome prediction in ANCA-associated renal vasculitis. Serum levels of complement components C3 and C4 were directly compared in association with clinical and outcome data in a r...

Therapeutic applications of toll-like receptors (TLRs) agonists in AML.
https://doi.org/10.1007/s12094-022-02917-5
Clinical & Translational Oncology : Official Publication ... Peng Y, Wang Y et. al.

Aug 14th, 2022 - Acute myeloid leukemia (AML) is an aggressive type of blood cancer affecting bone marrow (BM). In AML, hematopoietic precursors are arrested in the early stages of development and are defined as the presence of ≥ 20% blasts (leukemia cells) in the BM. Toll-like receptors (TLR) are major groups of pattern recognition receptors expressed by almost all innate immune cells that enable them to detec...

Etiology- and region-specific characteristics of transependymal cerebrospinal fluid flow.
https://doi.org/10.3171/2022.7.PEDS2246
Journal of Neurosurgery. Pediatrics; Yang PH, Almgren-Bell A et. al.

Aug 14th, 2022 - Transependymal flow (TEF) of CSF, often delineated as T2-weighted hyperintensity adjacent to the lateral ventricles on MRI, is a known imaging finding, usually in the setting of CSF flow disturbances. Specific radiological features of TEF and their relationships with clinical markers of hydrocephalus and underlying disease pathology are not known. Here, the authors describe the radiological fea...

The Origin, Application and Mechanism of Therapeutic Climbing: A Narrative Review.
https://doi.org/10.3390/ijerph19159696
International Journal of Environmental Research and Publi... Liu S, Gong X et. al.

Aug 13th, 2022 - As an innovative exercise therapy, therapeutic climbing (TC) has attracted more attention than ever before in recent years. In this review of the related studies on TC, the authors explore its origin and development; summarize its therapeutic effect in treating depression, low back pain and other diseases; and further analyze its underlying mechanism. According to the literature, TC was primari...

Benefits and harms of interventions to improve anxiety, depression, and other mental he...
https://doi.org/10.1177/13623613221117931
Autism : the International Journal of Research and Practice; Linden A, Best L et. al.

Aug 13th, 2022 - Nearly three out of four autistic people experience mental health problems such as stress, anxiety or depression. The research already done does not guide us on how best to prevent or treat mental health problems for autistic people. Our aim was to look at the benefits and harms of different interventions on mental health outcomes in autistic people. We searched all the published randomised con...

Alcohol and falls among people with HIV infection: A view from Russia and the United St...
https://doi.org/10.1111/acer.14915
Alcoholism, Clinical and Experimental Research; Kim TW, Heeren TC et. al.

Aug 13th, 2022 - Both human immunodeficiency virus (HIV) infection and alcohol use predispose to autonomic/sensory neuropathy, imbalance symptoms, and cognitive impairment-conditions associated with a greater risk of falls-yet it is unclear how to identify people with HIV (PWH) whose drinking is associated with falls. Research on alcohol and falls using the same instruments in different countries could help to ...