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About 875,470 results

Take steps to manage pseudoexfoliation glaucoma in cataract surgery
https://www.healio.com/news/ophthalmology/20220119/take-steps-to-manage-pseudoexfoliation-glaucoma-in-cataract-surgery

Jan 19th, 2022 - WAIKOLOA, Hawaii — Keep the cornea in mind and protect the endothelium when managing pseudoexfoliation glaucoma during cataract surgery, a presenter said here. “Consider femto if at all possible to decrease the ultrasound and combine with angle surgery, but skip the implants to save the cornea,” Malik Y. Kahook, MD, said at Hawaiian Eye 2022. The second key is to target the angle first and earl...

How to avoid the perils of uveitis diagnostic management
https://www.healio.com/news/ophthalmology/20220116/how-to-avoid-the-perils-of-uveitis-diagnostic-management

Jan 16th, 2022 - WAIKOLOA, Hawaii — It is important for physicians to consider “the perils that dwell” in the diagnostic management of patients with uveitis, Steven Yeh, MD, said during a presentation at Hawaiian Eye 2022. “With these patients being very complex oftentimes, we really just don’t want to miss something,” Yeh said. To better identify “the pearls amongst the perils” in uveitis diagnosis, it is impo...

VIDEO: Lee explains how to identify NMOSD in patients with optic neuritis
https://www.healio.com/news/ophthalmology/20210521/video-lee-explains-how-to-identify-nmosd-in-patients-with-optic-neuritis

May 21st, 2021 - WAILEA, Hawaii — In this video from Hawaiian Eye 2021, Andrew G. Lee, MD, discusses the important questions ophthalmologists should ask patients with optic neuritis to identify neuromyelitis optica spectrum disorder.

Narrower Impella Indication; Better TAVR in 90-Year-Olds; Statin Prescribing Nudge
https://www.medpagetoday.com/cardiology/prevention/102087

Dec 6th, 2022 - Vaccination against the flu showed mixed results for cardiovascular prevention in a large international trial. (The Lancet Global Health) Dietary supplements with the strongest evidence for cardiometabolic benefits: omega-3 fatty acids, folic acid, and coenzyme Q10. Other micronutrient supplements had no effects or, in the case of beta-carotene, even increased risk, according to a systematic re...

Fewer Hospitalizations With Farxiga; New Obesity Drug; Sotagliflozin Still in Limbo
https://www.medpagetoday.com/endocrinology/generalendocrinology/102086

Dec 6th, 2022 - Dapagliflozin (Farxiga) cut all-cause hospitalization risk for patients with chronic kidney disease regardless of diabetes status, according to a post-hoc analysis of the DAPA-CKD trial. (Annals of Internal Medicine) The dopamine receptor agonist bromocriptine, commonly used to treat conditions like type 2 diabetes and Parkinson's disease, improved blood pressure and arterial stiffness in teens...

Alzheimer's Hype and Hope; Severe COVID and Brain Aging; Low Use of New Neuro Drugs
https://www.medpagetoday.com/neurology/generalneurology/102085

Dec 6th, 2022 - An editorial by The Lancet aimed to balance hype and hope about the investigational Alzheimer's drug lecanemab. The NIH Toolbox Cognition Battery was sensitive to cognitive changes in children and young people with intellectual disability. (Neurology) Severe COVID-19 was linked with brain changes that mirrored those seen in old age. (Nature Aging) The FDA's decision to approve aducanumab (Aduhe...

Vaccination Cuts Long COVID Risk for Rheumatic Disease Patients
https://www.medscape.com/viewarticle/985089

Dec 6th, 2022 - Patients with rheumatic disease are at least half as likely to develop long COVID after a SARS-CoV-2 infection if they have been fully vaccinated against COVID-19, according to research published November 28 in Annals of the Rheumatic Diseases. Dr Zachary Wallace “Moreover, those who were vaccinated prior to getting COVID-19 had less pain and fatigue after their infection,” Zachary S. Wallace, ...

FDA Issues Updated Safety Alert on Endologix AAA Repair Grafts
https://www.medscape.com/viewarticle/985127

Dec 6th, 2022 - The US Food and Drug Administration (FDA) has issued an update to its January 2022 safety communication on the use of Endologix AFX endovascular grafts to treat patients with abdominal aortic aneurysm (AAA). The update includes the following new information in the patient labeling for the AFX2 device: An increase in the rate of type III endoleaks was detected with previous iterations of the AFX...

Genomic alterations and clinical outcomes in patients with dedifferentiated liposarcoma.
https://doi.org/10.1002/cam4.5502
Cancer Medicine; Jagosky MH, Anderson CJ et. al.

Dec 6th, 2022 - Patients with unresectable dedifferentiated liposarcoma (DDLPS) have poor overall outcomes. Few genomic alterations have been identified with limited therapeutic options. Patients treated at Levine Cancer Institute with DDLPS were identified. Next generation sequencing (NGS), immunohistochemistry (IHC), and fluorescence in situ hybridization (FISH) testing were performed on tumor tissue collect...

TFG::MET-rearranged soft tissue tumor: A rare infantile neoplasm with a distinct low-gr...
https://doi.org/10.1002/gcc.23111
Genes, Chromosomes & Cancer; Michal M, Ud Din N et. al.

Dec 6th, 2022 - This article presents 2 cases of TFG::MET-rearranged mesenchymal tumor, an extremely rare molecular subset among an emerging group of mesenchymal neoplasms with kinase gene (NTRK, BRAF, RET and others) alterations. Both tumors were congenital, occurred in female patients and presented as huge masses on the trunk and thigh, measuring 18 and 20 cm in the largest dimension. Both cases showed ident...

Ideal models of good inpatient care for adults with intellectual disability: Lessons fr...
https://doi.org/10.1177/00207640221140290
The International Journal of Social Psychiatry; Burrows L, Page G et. al.

Dec 6th, 2022 - In recent years, a significant proportion of inpatient facilities for people with intellectual disabilities and/or autism has been de-commissioned in England, This has resulted in individuals with intellectual disabilities being sent to distant hospitals far away from their families and carers leading to challenges in follow-up, community care and interventions. The impact of de-institutionalis...

The role of spirituality in people with amyotrophic lateral sclerosis and their caregiv...
https://doi.org/10.1017/S1478951522001511
Palliative & Supportive Care; Gonçalves F, Teixeira MI et. al.

Dec 6th, 2022 - There are few studies evaluating the role of spirituality and the role of spiritually integrated interventions in people with amyotrophic lateral sclerosis (PALS) and their caregivers. A scoping review was conducted to examine the nature and breadth of peer-reviewed literature on the role of spirituality, interventions integrating spirituality, and outcomes for PALS and their caregivers. A lite...

Risk Factors for Suffocation and Unexplained Causes of Infant Deaths.
https://doi.org/10.1542/peds.2022-057771
Pediatrics Parks SE, DeSisto CL et. al.

Dec 6th, 2022 - Observational studies have improved our understanding of the risk factors for sudden infant death syndrome, but separate examination of risk for sleep-related suffocation and unexplained infant deaths has been limited. We examined the association between unsafe infant sleep practices and sudden infant deaths (sleep-related suffocation and unexplained causes including sudden infant death syndro...

Progressive Multifocal Leukoencephalopathy in Multiple Myeloma.
https://doi.org/10.1111/ejh.13909
European Journal of Haematology; Hoeynck BW, Cohen AD et. al.

Dec 6th, 2022 - Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal demyelinating disease of the central nervous system caused by reactivation of the JC virus in the context of immune suppression such as HIV, malignancy, and certain immunomodulatory medications. PML has been reported only rarely in multiple myeloma patients, and its presenting features and natural history in this populat...

Spindle cell lipoma of the buccal mucosa: Uncommon finding in an older adult.
https://doi.org/10.1111/ger.12666
Gerodontology Brooks JK, Rostami A et. al.

Dec 6th, 2022 - This article reports a case of a longstanding, slowly enlarging intraoral spindle cell lipoma (SCL) that had become increasingly painful during mastication. The SCL represents an uncommon variant of the conventional lipoma. There is limited information regarding this lesion in the gerodontologic literature. A 68-year-old patient underwent an excisional biopsy of a 9-mm slightly yellow papule al...

The role of autophagy in idiopathic pulmonary fibrosis: from mechanisms to therapies.
https://doi.org/10.1177/17534666221140972
Therapeutic Advances in Respiratory Disease; Yue YL, Zhang MY et. al.

Dec 6th, 2022 - Idiopathic pulmonary fibrosis (IPF) is an interstitial pulmonary disease with an extremely poor prognosis. Autophagy is a fundamental intracellular process involved in maintaining cellular homeostasis and regulating cell survival. Autophagy deficiency has been shown to play an important role in the progression of pulmonary fibrosis. This review focused on the six steps of autophagy, as well as ...

Accuracy of narrow-band imaging in predicting the histology of anal intraepithelial les...
https://doi.org/10.1097/MEG.0000000000002457
European Journal of Gastroenterology & Hepatology; Pecere S, Hassan C et. al.

Dec 6th, 2022 - Anal intraepithelial neoplasia (AIN) is the precursor of anal squamous carcinoma, frequently underappreciated by most gastroenterologists. Purpose of the study is to assess the diagnostic accuracy of narrow-band imaging (NBI) in predicting the histology of anal lesions, considering a new NBI classification. This is a retrospective analysis of consecutive patients with suspected anal squamous in...

Building a deeper understanding of social relationship health in adolescents with narco...
https://doi.org/10.5664/jcsm.10372
Journal of Clinical Sleep Medicine : JCSM : Official Publ... Zhou ES, Revette A et. al.

Dec 6th, 2022 - Common symptoms for patients with narcolepsy can have a significant impact on social health. As one peak for symptom onset is adolescence, these symptoms impact social relationships during a critical developmental period. Much of the existing literature in this domain has relied on broad questionnaires, with less insight into the nuances of their potential social struggles. Adolescents (12-17 y...

A novel splice-site variant of the LAMB3 gene is associated with junctional epidermolys...
https://doi.org/10.1684/ejd.2022.4318
European Journal of Dermatology : EJD; Liang B, Meng D et. al.

Dec 6th, 2022 - Junctional epidermolysis bullosa (JEB) is a rare inherited genetic disorder in which pathogenic mutations are mostly located within exons of the associated genes. This report describes a novel variant located at a splice site. To confirm the diagnosis of the JEB family and identify the pathogenic variant. We collected clinical data and DNA from the members of the family. Whole-exome sequencing ...

The risk of glaucoma associated with phacomatosis cesioflammea and phacomatosis cesiofl...
https://doi.org/10.1684/ejd.2022.4317
European Journal of Dermatology : EJD; Huang S, Yang Y et. al.

Dec 6th, 2022 - The ocular features of phacomatosis pigmentovascularis (PPV) have rarely been reported, and glaucoma is the leading cause of blindness in patients with this condition. To protect vision in these patients, it is important to identify glaucoma as early as possible. To systematically report the systemic and ocular manifestations of phacomatosis cesioflammea and phacomatosis cesioflammeo-marmorata,...