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About 532,828 results

Lower bevacizumab doses, agents with less systemic exposure may be safer options for ROP
https://www.healio.com/news/ophthalmology/20220203/lower-bevacizumab-doses-agents-with-less-systemic-exposure-may-be-safer-options-for-rop

Feb 3rd, 2022 - WAIKOLOA, Hawaii — Systemic effects of anti-VEGF in retinopathy of prematurity have not been ruled out, so it may be wise to use bevacizumab in lower doses or switch to agents with less systemic exposure, according to one presenter. “The BEAT-ROP study demonstrated a beneficial effect for bevacizumab vs. laser in the treatment of zone I, stage 3+ ROP. But one thing I didn’t like was the complet...

Several pathways under investigation for dry AMD treatment
https://www.healio.com/news/ophthalmology/20220118/several-pathways-under-investigation-for-dry-amd-treatment

Jan 18th, 2022 - WAIKOLOA, Hawaii — Several pathways are under investigation for the treatment of dry age-related macular degeneration, according to a presentation at Retina 2022. “The big issue for us researchers is we don’t have a good animal model to test anything,” Peter K. Kaiser, MD, said. “We don’t have preclinical models that inform us if a drug is going to work or not because the animal that we use are...

Lingering Effects Seen With Non-COVID Respiratory Illness Too
https://www.medpagetoday.com/infectiousdisease/covid19/102011

Dec 1st, 2022 - People with acute respiratory illness during the pandemic suffered similar levels of poor well-being in the months afterward whether they tested positive for SARS-CoV-2 or not, a registry study showed. In a cohort of people who all had initial symptoms suggestive of COVID-19, those who had moderate to severe scores at 3 months on the pain, mood, and other quality-of-life measures on the Patient...

Does severe hypoxia during irradiation of Aedes aegypti pupae improve sterile male perf...
https://doi.org/10.1186/s13071-022-05577-0
Parasites & Vectors; Tussey DA, Linthicum KJ et. al.

Nov 30th, 2022 - The yellow fever mosquito, Aedes aegypti, vectors several pathogens responsible for human diseases. As a result, this mosquito species is a priority for control by mosquito control districts in Florida. With insecticide resistance development becoming a concern, alternative control strategies are needed for Ae. aegypti. Sterile insect technique (SIT) is an increasingly popular option that is be...

Statistical inferences of HIVRNA and hepatocellular carcinoma based on the PAK1 express...
https://doi.org/10.2174/1570162X21666221128153942
Current HIV Research; Yuan Z, Ma R et. al.

Nov 30th, 2022 - Acquired immune deficiency syndrome and hepatocellular carcinoma are all serious hazard to human health that creates a widespread alarm. Biomarkers that are closely linked to HIVRNA and hepatocellular carcinoma are unknown. 48 cases with HIV and hepatocellular carcinoma and 112 normal cases were recruited. Blood neutrophil count (NEU), white blood cell count (WBC), PAK1 and HIVRNA with hepatoce...

Effectiveness and safety of COVID-19 vaccine in pregnant women: a systematic review wit...
https://doi.org/10.1111/1471-0528.17354
BJOG : an International Journal of Obstetrics and Gynaeco... Tormen M, Taliento C et. al.

Nov 30th, 2022 - There are limited data regarding COVID-19 vaccination during pregnancy. To evaluate the effects of COVID-19 vaccination received during pregnancy on SARS-CoV-2 infection, COVID-19-related hospitalisation, COVID-19-related ICU admission and maternal-fetal complications. MEDLINE, CINHAL, Embase, Scopus, CENTRAL databases; ClinicalTrials.gov, reference lists, related articles and grey literature s...

Circ_0000253 promotes the progression of osteosarcoma via the miR-1236-3p/SP1 axis.
https://doi.org/10.1093/jpp/rgac081
The Journal of Pharmacy and Pharmacology; Xu L, Duan J et. al.

Nov 30th, 2022 - Circular RNAs (circRNAs) play important roles in modulating tumour progression. This study investigated the role of circ_0000253 in osteosarcoma (OS). We downloaded the chip dataset GSE140256 from the Gene Expression Omnibus database and the circRNAs differentially expressed in OS tissue and normal tissue samples were analysed. Quantitative real-time PCR (qRT-PCR) was carried out to examine cir...

The Performance of Interferon-gamma Release Assays and Tuberculin Skin Tests in the Dia...
https://doi.org/10.2174/1871526523666221128140615
Infectious Disorders Drug Targets; Abedi F, Farkhondeh T et. al.

Nov 30th, 2022 - Diagnosis and treatment of latent tuberculosis infection (LTBI) in populations under TNF-α antagonists therapy are critical strategies for preventing active tuberculosis (TB). The diagnostic accuracy of IGRAs and the TST for diagnosis of LTBI in patients with IMIDs remains unclear. Accuracy measures of IGRAs and TST were pooled with random effects model. The sensitivity and specificity in IMID ...

THE IMPACT OF PANCREATIC CANCER SCREENING ON LIFE EXPECTANCY: A SYSTEMATIC REVIEW OF MO...
https://doi.org/10.1002/ijc.34379
International Journal of Cancer; Koopmann BDM, Omidvari AH et. al.

Nov 30th, 2022 - Evidence supporting the effectiveness of pancreatic cancer (PC) screening is scant. Most clinical studies concern small populations with short follow-up durations. Mathematical models are useful to estimate long-term effects of PC screening using short-term indicators. This systematic review aims to evaluate the impact of PC screening on life expectancy (LE) in model-based studies. Therefore, w...

Intellectual disabilities moderate sex/gender differences in autism spectrum disorder: ...
https://doi.org/10.1111/jir.12989
Journal of Intellectual Disability Research : JIDR; Saure E, Castrén M et. al.

Nov 30th, 2022 - Girls/women with autism spectrum disorder (ASD) are suggested to exhibit different symptom profiles than boys/men with ASD. Accumulating evidence suggests that intellectual disability (ID) may affect sex/gender differences in ASD. However, a systematic review and meta-analysis on this topic is missing. Two databases (MEDLINE and PsycINFO) were used to search for studies reporting sex/gender dif...

Expanding the clinical spectrum of idiopathic intracranial hypertension.
https://doi.org/10.1097/WCO.0000000000001131
Current Opinion in Neurology; Chen BS, Britton JOT

Nov 30th, 2022 - Idiopathic intracranial hypertension (IIH) is a disorder of raised intracranial pressure (ICP). Although the majority of patients with IIH present classically with headache and papilledema, some patients may have unusual presentations or manifestations. Recent advancements in neuroimaging have facilitated the identification of other presentations associated with IIH. This review provides an ove...

Characterization of the Cytopathic Effects of Monkeypox Virus Isolated from Clinical Sp...
https://doi.org/10.1128/jcm.01336-22
Journal of Clinical Microbiology; Ma A, Langer J et. al.

Nov 30th, 2022 - While the practice of viral culture has largely been replaced by nucleic acid amplification tests, circumstances still exist in which the availability of viral culture will allow for the diagnosis of infections not included in a provider's differential diagnosis. Here, we examine the cytopathic effects (CPE) and clinical data associated with 18 cases of monkeypox virus (MPXV) isolated from 19 c...

LINC00629, a KLF10-responsive lncRNA, promotes the anticancer effects of apigenin by de...
https://doi.org/10.18632/aging.204396
Aging Shi C, Ma C et. al.

Nov 30th, 2022 - Apigenin, a naturally occurring flavonoid, is known to exhibit antitumor activity in many cancers. However, the regulatory mechanism of apigenin and the long noncoding RNAs (lncRNAs) altered upon apigenin treatment in oral squamous cell carcinoma (OSCC) remain unclear. In this study, we found that LINC00629 was significantly upregulated in response to apigenin treatment. Upregulated LINC00629 e...

Artificial Intelligence-Assisted Classification of Gliomas Using Whole-Slide Images.
https://doi.org/10.5858/arpa.2021-0518-OA
Archives of Pathology & Laboratory Medicine; Jose L, Liu S et. al.

Nov 30th, 2022 - Glioma is the most common primary brain tumor in adults. The diagnosis and grading of different pathological subtypes of glioma is essential in treatment planning and prognosis. To propose a deep learning-based approach for the automated classification of glioma histopathology images. Two classification methods, the ensemble method based on 2 binary classifiers and the multiclass method using a...

Malus toringoides (Rehd.) Hughes Ameliorates Nonalcoholic Fatty Liver Disease with Diab...
https://doi.org/10.1089/jmf.2022.K.0080
Journal of Medicinal Food; Xie M, Gao L et. al.

Nov 30th, 2022 - Diabetic patients are more prone to developing nonalcoholic fatty liver disease (NAFLD) compared with healthy people. As a plant homologous to both medicine and food, Malus toringoides (Rehd.) Hughes has been used as an intervention for both NAFLD and diabetes. However, the effect and mechanism of M. toringoides on NAFLD on type 2 diabetes mellitus (T2DM) is unclear. The current investigation w...

Celastrol assuages oxygen-glucose deprivation and reoxygenation-induced damage in human...
https://doi.org/10.1007/s11011-022-01106-1
Metabolic Brain Disease; Liu C, Gu J et. al.

Nov 30th, 2022 - The effect of Celastrol on cerebral ischemia-reperfusion remains unknown. The study aims to explore the role of circular RNA DLGAP4 (circDLGAP4) in cerebral ischemia-reperfusion and the underlying mechanism. Ischemia-reperfusion (I/R) injury of human brain microvascular endothelial cells (HBMECs) was induced by oxygen-glucose deprivation and reoxygenation (OGD/R). Reverse transcription quantita...

The Effects of Time Window-Averaged Mobility on Effective Reproduction Number of COVID-...
https://doi.org/10.1007/s11524-022-00697-5
Journal of Urban Health : Bulletin of the New York Academ... Kodera S, Hikita K et. al.

Nov 30th, 2022 - During epidemics, the estimation of the effective reproduction number (ERN) associated with infectious disease is a challenging topic for policy development and medical resource management. The emergence of new viral variants is common in widespread pandemics including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A simple approach is required toward an appropriate and timel...

Neurological Complications Following COVID-19 Vaccination.
https://doi.org/10.1007/s11910-022-01247-x
Current Neurology and Neuroscience Reports; Chatterjee A, Chakravarty A

Nov 30th, 2022 - A variety of neurological complications have been reported following the widespread use of the COVID-19 vaccines which may lead to vaccine hesitancy and serve as a major barrier to the public health aim of achieving protective herd immunity by vaccination. In this article, we review the available evidence regarding these neurological adverse events reported, to provide clarity regarding the sam...

Analysis of Clinical Outcomes of Pregnant Patients Treated With Nirmatrelvir and Ritona...
https://doi.org/10.1001/jamanetworkopen.2022.44141
JAMA Network Open; Garneau WM, Jones-Beatty K et. al.

Nov 30th, 2022 - Pregnant people are at increased risk of poor outcomes due to infection with SARS-CoV-2, and there are limited therapeutic options available. To evaluate the clinical outcomes associated with nirmatrelvir and ritonavir used to treat SARS-CoV-2 infection in pregnant patients. This case series included pregnant patients who were diagnosed with SARS-CoV-2 infection, received nirmatrelvir and riton...

Treatment options for resectable hypopharyngeal squamous cell carcinoma: A systematic r...
https://doi.org/10.1371/journal.pone.0277460
PloS One; Panda S, Sakthivel P et. al.

Nov 30th, 2022 - There is uncertainty in the treatment options for resectable hypopharyngeal squamous cell carcinoma. A systematic review of randomised controlled trials (RCTs) was performed. Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library), MEDLINE, EMBASE, Science Citation Index, and Conference Proceedings databases and trial registries were searched until November 2020 for rand...