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About 22,790 results

Effects of endurance training on the expression of host proteins involved in SARS-CoV-2...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440939
Physiological Reports; Tamura Y, Jee E et. al.

Sep 16th, 2021 - The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is threatening people's lives and impacting their health. It is still unclear whether people engaged in physical activity are at an increased risk of SARS-CoV-2 infection and severe forms of COVID-19. In order to provide data to help answer this question, we, therefore, inve...

Theaflavin-3'-O-gallate a Black-tea Constituent Blocked SARS CoV-2 RNA dependant RNA Po...
https://doi.org/10.1055/a-1467-5828
Drug Research; Banerjee A, Kanwar M et. al.

Sep 14th, 2021 - Replication of SARS-CoV-2 depends on viral RNA-dependent RNA-polymerase (RdRp). Remdesivir, the broad-spectrum RdRp inhibitor acts as nucleoside-analogues (NAs). Remdesivir has initially been repurposed as a promising drug against SARS-CoV-2 infection with some health hazards like liver damage, allergic reaction, low blood-pressure, and breathing-shortness, throat-swelling. In comparison, theaf...

The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structura...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413341
Nature Communications; Safarian S, Opel-Reading HK et. al.

Sep 4th, 2021 - New drugs are urgently needed to combat the global TB epidemic. Targeting simultaneously multiple respiratory enzyme complexes of Mycobacterium tuberculosis is regarded as one of the most effective treatment options to shorten drug administration regimes, and reduce the opportunity for the emergence of drug resistance. During infection and proliferation, the cytochrome bd oxidase plays a crucia...

Improved Synthesis of a Cyclic Glutamine Analogue Used in Antiviral Agents Targeting 3C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425337
The Journal of Organic Chemistry; Vuong W, Vederas JC

Aug 31st, 2021 - An intermediate in the synthesis of numerous antiviral protease inhibitors is the glutamine analogue, (3S)-pyrrolid-2-one-3-yl-l-alanine. Preparations of compounds based on this pharmacophore are hindered by the lack of a reliably high yielding synthesis of protected forms of this amino acid. We describe an improved scalable route with readily available reagents and facile purification. This me...

Paradoxical effects of cigarette smoke and COPD on SARS-CoV-2 infection and disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381712
BMC Pulmonary Medicine; Tomchaney M, Contoli M et. al.

Aug 25th, 2021 - How cigarette smoke (CS) and chronic obstructive pulmonary disease (COPD) affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection and severity is controversial. We investigated the effects of COPD and CS on the expression of SARS-CoV-2 entry receptor ACE2 in vivo in COPD patients and controls and in CS-exposed mice, and the effects of CS on SARS-CoV-2 infection in human bro...

Hypoxia alters the expression of ACE2 and TMPRSS2 SARS-CoV-2 cell entry mediators in hC...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372440
Microvascular Research; Imperio GE, Lye P et. al.

Aug 21st, 2021 - The mechanisms by which the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) induces neurological complications remain to be elucidated. We aimed to identify possible effects of hypoxia on the expression of SARS-CoV-2 cell entry mediators, angiotensin-converting enzyme 2 (ACE2) receptor and transmembrane protease serine 2 (TMPRSS2) protein, in human brain endothelial cells, in vitro...

The potential role of abnormal angiotensin-converting enzyme 2 expression correlated wi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457607
Aging Jiang Y, Chen L et. al.

Aug 21st, 2021 - The potential role of abnormal ACE2 expression after SARS-CoV-2 infection in the prognosis of breast cancer is still ambiguous. In this study, we analyzed ACE2 changes in breast cancer and studied the correlation between ACE2 and the prognosis and further analyzed the relationship between immune infiltration and the prognosis of different breast cancer subtypes. Finally, we inferred the prognos...

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 he...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358061
Nature Communications; Newman JA, Douangamath A et. al.

Aug 13th, 2021 - There is currently a lack of effective drugs to treat people infected with SARS-CoV-2, the cause of the global COVID-19 pandemic. The SARS-CoV-2 Non-structural protein 13 (NSP13) has been identified as a target for anti-virals due to its high sequence conservation and essential role in viral replication. Structural analysis reveals two "druggable" pockets on NSP13 that are among the most conser...

A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475528
Journal of Virology; Lu M, Zhang Y et. al.

Aug 12th, 2021 - The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to dramatic economic and health burdens. Although the worldwide SARS-CoV-2 vaccination campaign has begun, exploration of other vaccine candidates is needed due to uncertainties with the current approved vaccines, such as durability of protection, cross-prot...

A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349458
Antiviral Research; Leach A, Ilca FT et. al.

Aug 11th, 2021 - The SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2) was previously engineered into a high affinity tetravalent format (ACE2-Fc-TD) that is a potential decoy protein in SARS-CoV-2 infection.We report that this protein shows greatly enhanced binding to SARS-CoV-2 spike proteins of the SARS-CoV-2 variants of concern B.1.1.7 (alpha variant, originally isolated in the United Kingdom) and ...

Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papai...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342870
International Journal of Biological Macromolecules; Xu Y, Chen K et. al.

Aug 9th, 2021 - COVID-19 is a disease caused by SARS-CoV-2, which has led to more than 4 million deaths worldwide. As a result, there is a worldwide effort to develop specific drugs for targeting COVID-19. Papain-like protease (PLpro) is an attractive drug target because it has multiple essential functions involved in processing viral proteins, including viral genome replication and removal of post-translation...

Gene of the month: FH.
https://doi.org/10.1136/jclinpath-2021-207830
Journal of Clinical Pathology; Zyla RE, Hodgson A

Aug 7th, 2021 - Fumarate hydratase (FH), encoded by the FH gene, is an enzyme which catalyses the conversion of fumarate to L-malate as part of the tricarboxylic acid cycle. Biallelic germline mutations in FH result in fumaric aciduria, a metabolic disorder resulting in severe neurological and developmental abnormalities. Heterozygous germline mutations in FH result in hereditary leiomyomatosis and renal cell ...

RNA-dependent protein kinase is required for interferon-γ-induced autophagy in MG63 ost...
https://doi.org/10.1016/j.gene.2021.145865
Gene Xu J, Ji Y et. al.

Aug 6th, 2021 - Osteosarcoma is a bone tumor that mainly affects children and adolescents. Interferons (IFNs) have been shown to exert antitumor effects in osteosarcoma cells, although the molecular mechanisms have not been fully realized. We investigated IFN-γ actions on osteosarcoma cells. Our results show that IFN-γ induces the accumulation of autophagosomes in osteosarcoma cells. IFN-γ treatment leads to t...

Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CLpro: Inh...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322037
International Journal of Biological Macromolecules; Xiong Y, Zhu GH et. al.

Aug 2nd, 2021 - Coronavirus 3C-like protease (3CLpro) is a crucial target for treating coronavirus diseases including COVID-19. Our preliminary screening showed that Ampelopsis grossedentata extract (AGE) displayed potent SARS-CoV-2-3CLpro inhibitory activity, but the key constituents with SARS-CoV-2-3CLpro inhibitory effect and their mechanisms were unrevealed. Herein, a practical strategy via integrating bio...

Should temozolomide be used on the basis of O6-methylguanine DNA methyltransferase stat...
https://doi.org/10.1016/j.ctrv.2021.102261
Cancer Treatment Reviews; Trillo Aliaga P, Spada F et. al.

Aug 1st, 2021 - Temozolomide (TEM) is an active treatment in metastatic neuroendocrine tumors (NETs). Patients affected by glioblastoma multiforme or advanced melanoma treated with TEM who have deficiency of O6-methylguanine DNA methyltransferase (MGMT) have a better responses and survival. However, the predictive role of MGMT in patients with NETs treated with TEM is still debated. We conducted a systematic r...

Variants in CASP10, a diagnostic challenge: Single center experience and review of the ...
https://doi.org/10.1016/j.clim.2021.108812
Clinical Immunology (Orlando, Fla.); Matas Pérez E, Valdivieso Shephard JL et. al.

Jul 31st, 2021 - Autoimmune lymphoproliferative syndrome is a primary immunodeficiency caused by variants in FAS-mediated apoptosis related genes and is characterized by lymphadenopathy, splenomegaly and autoimmunity. A total of six different variants in CASP10 have been described as potential causative of disease, although two of them have recently been considered polymorphisms. The high allele frequency of th...

In Silico Mutagenesis-Based Remodelling of SARS-CoV-1 Peptide (ATLQAIAS) to Inhibit SAR...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319699
Interdisciplinary Sciences, Computational Life Sciences; Khan A, Umbreen S et. al.

Jul 30th, 2021 - The prolific spread of COVID-19 caused by a novel coronavirus (SARS-CoV-2) from its epicenter in Wuhan, China, to every nook and cranny of the world after December 2019, jeopardize the prevailing health system in the world and has raised serious concerns about human safety. Multi-directional efforts are made to design small molecule inhibitors, and vaccines and many other therapeutic options ar...

Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Sever...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530207
Arteriosclerosis, Thrombosis, and Vascular Biology; Caescu CI, Hansen J et. al.

Jul 30th, 2021 - Despite considerable research, the goal of finding nonsurgical remedies against thoracic aortic aneurysm and acute aortic dissection remains elusive. We sought to identify a novel aortic PK (protein kinase) that can be pharmacologically targeted to mitigate aneurysmal disease in a well-established mouse model of early-onset progressively severe Marfan syndrome (MFS). Computational analyses of t...

Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351954
PLoS Pathogens; Cai Y, Jaecklein E et. al.

Jul 29th, 2021 - In order to sustain a persistent infection, Mycobacterium tuberculosis (Mtb) must adapt to a changing environment that is shaped by the developing immune response. This necessity to adapt is evident in the flexibility of many aspects of Mtb metabolism, including a respiratory chain that consists of two distinct terminal cytochrome oxidase complexes. Under the conditions tested thus far, the bc1...

Molecular docking and dynamics study to explore phytochemical ligand molecules against ...
https://doi.org/10.1080/17512433.2021.1959318
Expert Review of Clinical Pharmacology; Mahmud S, Mita MA et. al.

Jul 25th, 2021 - The high transmission and pathogenicity of SARS-CoV-2 has led to a pandemic that has halted the world's economy and health. The newly evolved strains and scarcity of vaccines has worsened the situation. The main protease (Mpro) of SARS-CoV-2 can act as a potential target due to its role in viral replication and conservation level. In this study, we have enlisted more than 1100 phytochemicals fr...