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Mortality Rate Related to COVID-19 in Rheumatic and Musculoskeletal Diseases (RMDs)
Ines Perez - Sancristobal, Dalifer Freites, Leticia Lopez Pedraza et. al.

Nov 9th, 2021 - Background/Purpose: In patients with rheumatic and musculoskeletal diseases (RMDs) and infected with Covid – 19, a) we want to assess the mortality rate (MR) related to COVID-19; and b) to analyze the role of RMDs in mortality risk. Methods: An observational longitudinal study was conducted during the epidemic peak in Madrid (1stMar to 20thMay2020). All patients attended at the rheumatology out...

Does Limited Stair Climbing Lead to Poor Future Health? The Relationship Between Short-term Trajectories of Stair Climbing Frequency and Incident Slow Gait Speed over 1 and 2 Years in Adults with K...
Jason Jakiela, Yuqing Zhang, Dana Voinier et. al.

Nov 9th, 2021 - Background/Purpose: Knee osteoarthritis (OA) is a common cause of functional limitation in older adults, and difficulty with climbing stairs is one of the first limitations to be reported. As such, reducing the frequency of stair climbing may serve as an early warning sign of future poor health outcomes. Little is known, however, about how stair use may fluctuate over time and if such fluctuati...

Disease Activity and Outcome in Pregnancies of Patients with SpA – Data from the German Pregnancy Register RHEKISS
Anja Weiß, Christina Bungartz, Jutta Richter et. al.

Nov 9th, 2021 - Background/Purpose: SpA is a severe chronic inflammatory disease, which affects quality of life and functional status. It frequently occurs in women of childbearing age. Active disease and TNFi discontinuation at early pregnancy were found to be risk factors for flares during pregnancy (1). The aim of this study was to compare disease activity during pregnancy in patients with or without biolog...

Factors Associated with COVID-19 Vaccine Hesitancy Among Individuals with Rheumatic Disease
Kristin Wipfler, Adam Cornish, Alison Freifeld et. al.

Nov 9th, 2021 - Background/Purpose: COVID-19 vaccination efforts are ongoing and there is a need to understand factors associated with vaccine hesitancy. Individuals with rheumatic diseases have been uniquely impacted by the COVID-19 pandemic and little is known about vaccine acceptance rates in this population in the United States. The objective of this study was to identify reasons for vaccine hesitancy as w...

Phenome-Wide Association of Gout Risk Loci
Oleg Stens, Vivian Trang, Steven Cao et. al.

Nov 9th, 2021 - Background/Purpose: Gout is a complex disease involving changes in urate biology and inflammatory responses, and is associated with comorbidities including metabolic syndrome and cardiorenal disease. Phenome-Wide Association Study (PheWAS) is a novel analytical technique where genetic variants are interrogated against a large set of phenotypic traits. PheWAS are a powerful tool to characterize ...

Has the Incidence of Total Joint Arthroplasty in Rheumatoid Arthritis Decreased in the Era of Biologics Use? A Population-based Incident Cohort Study 1995–2015
Vivienne Zhou, Diane Lacaille, Na Lu et. al.

Nov 9th, 2021 - Background/Purpose: Total joint arthroplasty (TJA) is an undesirable long-term outcome of rheumatoid arthritis (RA) due to joint damage from uncontrolled inflammation. Although biological disease-modifying anti-rheumatic drugs (bDMARDs) would be expected to reduce the need for TJA due to better control of inflammation, evidence is conflicting. We aim to investigate whether the introduction of b...

Relation of Foot and Ankle Pain to Worsening Knee Pain: The MOST Study
Patrick Corrigan, David Felson, Tuhina Neogi et. al.

Nov 9th, 2021 - Background/Purpose: Foot and ankle pain may be a risk factor for worsening knee pain in those with or at risk for knee osteoarthritis (KOA). Foot and ankle pain is associated with biomechanical alterations that shift load from the foot and ankle to the knees. Since increased knee joint loading is a well-established risk factor for KOA, foot and ankle pain may play a key role in the onset and pr...

Risk of Other Autoimmune Conditions Among Relatives of Patients with Rheumatoid Arthritis
Katherine Liao, Thany Seyok1 and Lisa Cannon-Albright, Brigham and Women's Hospital et. al.

Nov 9th, 2021 - Background/Purpose: Autoimmune conditions appear to cluster in families, as may be expected by shared genetic risk factors in conditions such as rheumatoid arthritis (RA), autoimmune thyroiditis (AITD), celiac disease, and systemic lupus erythematosus (SLE). However, these conditions are polygenic, individual risk alleles have small effect sizes, and only a handful of alleles are shared across ...

Isolated Axial versus Concomitant Peripheral Disease in Psoriatic Arthritis
Timothy Kwok, Mitchell Sutton, Richard Cook et. al.

Nov 9th, 2021 - Background/Purpose: Isolated axial involvement exists in 2 to 5% of all psoriatic arthritis (PsA) patients. However, it is currently unknown whether patients with isolated axial disease are clinically different than those with concomitant peripheral disease. The primary objective of this study was to determine clinical features associated with isolated axial disease among PsA patients with axia...

Increased Prevalence of Gastroesophageal Disease Among Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis
Patompong Ungprasert, Nipith Charoenngam, Ben Ponvilawan et. al.

Nov 9th, 2021 - Background/Purpose: Recent experimental studies have suggested that systemic inflammatory response could lead to impairment of lower esophageal function, resulting in gastroesophageal reflux disease (GERD). Epidemiologic studies also support this association as increased prevalence of GERD has been observed in several systemic inflammatory disorders, including rheumatoid arthritis (RA), althoug...

What Is Peripheral SpondyloArthritis? Identifying Disease Phenotype and Burden: A Post Hoc Analysis of the ASAS-PerSpA International Study
Nelly Ziade, Joe Rassi, Bassel Elzorkany et. al.

Nov 9th, 2021 - Background/Purpose: Peripheral spondyloarthritis (pSpA) shows features that overlap with psoriatic arthritis (PsA), axial spondyloarthritis (axSpA) and other forms of SpA and is unsatisfactorily defined despite the introduction of the ASAS classification criteria in 2011. The objective of this study was to estimate the prevalence of pSpA among patients with SpA, to identify the phenotype and bu...

Epidemiology of Musculoskeletal Manifestations in Paediatric Inflammatory Bowel Disease: A Systematic Review
Aaisham Ali, Melanie Schmidt, David Piskin et. al.

Nov 9th, 2021 - Background/Purpose: Paediatric inflammatory bowel disease (p-IBD) is a chronic and relapsing gastrointestinal disorder of childhood with associated long-term morbidity. Several extraintestinal manifestations (EIMs) are described, the most common being joint pain and/or inflammation. In 1986, Passo et al. were the first to describe the association of arthritis in p-IBD patients. In this retrospe...

Incidence, Prevalence, and Mortality of Chronic Periaortitis: A Population-based Study
Umar Ghaffar, Kenneth Warrington, Stephanie Duong et. al.

Nov 9th, 2021 - Background/Purpose: Chronic periaortitis is an inflammatory condition that typically involves the infrarenal portion of the abdominal aorta. To date, no epidemiologic studies have been performed in North America. The purpose of this study was to evaluate the epidemiology, presentation and outcomes of patients with chronic periaortitis from 1998 through 2018. Methods: An inception cohort of pati...

Adverse Outcomes and Rehospitalization After Delivery Among Women with Systemic Lupus Erythematosus or Rheumatoid Arthritis and Their Infants
Julianna Sabo, Namrata Singh, Deborah Crane et. al.

Nov 9th, 2021 - Background/Purpose: Women with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) have greater risk of adverse obstetric and birth outcomes than women without these conditions. Infant outcomes are less well-studied. It is unknown whether re-hospitalization after delivery occurs more often for affected mothers and their infants. Methods: This population-based cohort study used linke...

Epidemiology of Comorbidities in an Incident Psoriasis Cohort: A Population-Based Study
Paras Karmacharya, Rikesh Chakradhar, Alexis Ogdie et. al.

Nov 8th, 2021 - Background/Purpose: Psoriasis, a chronic immune-mediated skin disease affecting 2-4% of the US population, is increasingly recognized as a systemic inflammatory disorder associated with cardiometabolic and other comorbidities. Additionally, psoriasis frequently precedes the development of psoriatic arthritis (PsA) and among patients with psoriasis, certain comorbidities may be risk factors for ...

Causes of Death Among Populations with Systemic Lupus Erythematosus by Race and Ethnicity
Tiffany Taylor, Christine Anastasiou, Stephanie Rush et. al.

Nov 8th, 2021 - Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease with manifestations that vary widely in severity. Data indicate that minority populations are at higher risk of developing SLE and have more severe outcomes, including mortality. However, whether specific causes of death vary by race and ethnicity has largely been unexplored, particularly for Asians and ...

Female Reproductive Factors and Risk of Joint Replacement Arthroplasty of the Knee and Hip Due to Osteoarthritis in Postmenopausal Women: A Nationwide Cohort Study of 1.36 Million Women
Yeonghee Eun, Jung Eun Yoo, Kyungdo Han et. al.

Nov 8th, 2021 - Background/Purpose: Previous studies of the relationships between female reproductive factors and osteoarthritis (OA) have shown conflicting results. In this study, we aimed to explore the relationships between reproductive factors and joint replacement arthroplasty of the knee (TKRA) and hip (THRA) in a large nationwide population-based cohort of postmenopausal Korean women. Methods: We includ...

Epidemiology and Clinical Features of Ophthalmological Manifestations in Behçet’s Disease: Study of 50 Patients of a Series of 120 Patients in a Region in Northern Spain
Alba Herrero-Morant, Guillermo Suárez-Amorín, Rosalia Demetrio-Pablo et. al.

Nov 8th, 2021 - Background/Purpose: Ophthalmological involvement is one of the most feared manifestations of Behçet’s disease.The aim of this study was to define the main demographic and clinical features of ophthalmological involvement in a well-defined cohort of patients with Behçet’s disease. Methods: Descriptive study of a cohort of 120 patients diagnosed with Behçet’s disease from January 1, 1980 to Decem...

Osteoarthritis Risk Is Increased in Patients with Atopic Disease
Matthew Baker, Khushboo Sheth, Rong Lu et. al.

Nov 8th, 2021 - Background/Purpose: Osteoarthritis (OA) is a highly prevalent disease resulting in joint pain and impaired function. Allergic pathways, including mast cell activation, may play a key role in the pathogenesis of OA.1 The association between atopic disease and the development of OA is not well understood. The objective of this study was to determine the incidence of OA in patients with atopic dis...

How to Optimize E-Recruitment Strategies: Lessons Learned from over 3000 Participants in an International Arab Online Study
Ihsane Hmamouchi, Lina El Kibbi, Nizar Abdulateef et. al.

Nov 8th, 2021 - Background/Purpose: The use of online surveys as a recruitment tool for clinical research has increased during the COVID-19 pandemic and will likely continue to expand. However, good practice guidance for investigators and steering committees to optimize their digital recruitment strategies is still needed. The aim of this study was to identify the most effective strategies for digital recruitm...