×
About 9,583 results

COVID-19-Associated Hospitalizations Among Adults During SARS-CoV-2 Delta and Omicron V...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956338
MMWR. Morbidity and Mortality Weekly Report; Taylor CA, Whitaker M et. al.

Mar 25th, 2022 - Beginning the week of December 19-25, 2021, the B.1.1.529 (Omicron) variant of SARS-CoV-2 (the virus that causes COVID-19) became the predominant circulating variant in the United States (i.e., accounted for >50% of sequenced isolates).* Information on the impact that booster or additional doses of COVID-19 vaccines have on preventing hospitalizations during Omicron predominance is limited. Dat...

Phase 2 Trial of Iberdomide in Systemic Lupus Erythematosus.
https://doi.org/10.1056/NEJMoa2106535
The New England Journal of Medicine; Merrill JT, Werth VP et. al.

Mar 17th, 2022 - Iberdomide, a cereblon modulator promoting degradation of the transcription factors Ikaros and Aiolos, which affect leukocyte development and autoimmunity, is being evaluated for the treatment of systemic lupus erythematosus (SLE). In this phase 2 trial, we randomly assigned patients in a 2:2:1:2 ratio to receive oral iberdomide (at a dose of 0.45, 0.30, or 0.15 mg) or placebo once daily for 24...

Hospitalizations and Mortality From Non-SARS-CoV-2 Causes Among Medicare Beneficiaries ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908076
JAMA Network Open; Dang A, Thakker R et. al.

Mar 10th, 2022 - The increased hospital mortality rates from non-SARS-CoV-2 causes during the SARS-CoV-2 pandemic are incompletely characterized. To describe changes in mortality rates after hospitalization for non-SARS-CoV-2 conditions during the COVID-19 pandemic and how mortality varies by characteristics of the admission and hospital. Retrospective cohort study from January 2019 through September 2021 using...

Tumor molecular differences associated with outcome disparities of Black patients with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047510
Head & Neck; Kim HAJ, Zeng PYF et. al.

Feb 22nd, 2022 - Numerous studies of head and neck squamous cell carcinoma (HNSCC) have demonstrated disparate outcomes by race and ethnicity. Beyond known associations with socioeconomic variables, whether these are also associated with differences in tumor molecular composition has thus far been poorly explored. We downloaded clinical and multiplatform molecular data from The Cancer Genome Atlas and other pub...

The genetic landscape of pancreatic head ductal adenocarcinoma in China and prognosis s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855595
BMC Cancer; Yang Y, Ding Y et. al.

Feb 20th, 2022 - Pancreatic ductal adenocarcinoma (PDAC) is the major subtype of pancreatic cancer and head PDACs show distinct characteristics from body/tail PDACs. With limited studies based on Asian population, the mutational landscape of Asian PDAC remains unclear. One hundred fifty-one Chinese patients with head PDAC were selected and underwent targeted 425-gene sequencing. Genomic alterations, tumor mutat...

Comparison of Racial, Ethnic, and Geographic Location Diversity of Participants Enrolle...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844998
JAMA Network Open; Stewart J, Krows ML et. al.

Feb 15th, 2022 - Racial and ethnic diversity among study participants is associated with improved generalizability of clinical trial results and may address inequities in evidence that informs public health strategies. Novel strategies are needed for equitable access and recruitment of diverse clinical trial populations. To investigate demographic and geographical location data for participants in 2 remote COVI...

Using dipstick urinalysis to predict development of acute kidney injury in patients wit...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805668
BMC Nephrology; McAdams MC, Li M et. al.

Feb 3rd, 2022 - Acute kidney injury (AKI) is a common complication in patients hospitalized with COVID-19 and may require renal replacement therapy (RRT). Dipstick urinalysis is frequently obtained, but data regarding the prognostic value of hematuria and proteinuria for kidney outcomes is scarce. Patients with positive severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) PCR, who had a urinalysis obtai...

Prevalence and Cumulative Risk of Familial Idiopathic Dilated Cardiomyopathy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808323
JAMA Huggins GS, Kinnamon DD et. al.

Feb 2nd, 2022 - Idiopathic dilated cardiomyopathy (DCM) aggregates in families, and early detection in at-risk family members can provide opportunity to initiate treatment prior to late-phase disease. Most studies have included only White patients, yet Black patients with DCM have higher risk of heart failure-related hospitalization and death. To estimate the prevalence of familial DCM among DCM probands and t...

Cutaneous leishmaniasis in a 12-year-old Syrian immigrant.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900756
CMAJ : Canadian Medical Association Journal = Journal De ... Alghounaim M, Chivinski J et. al.

Jan 26th, 2022 - Cutaneous leishmaniasis in a 12-year-old Syrian immigrant.|2022|Alghounaim M,Chivinski J,Barkati S,|therapeutic use,therapeutic use,diagnosis,drug therapy,pathology,ethnology,

CpG site hypomethylation at ETS1‑binding region regulates DLK1 expression in Chinese pa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809049
Molecular Medicine Reports; Tian G, He L et. al.

Jan 22nd, 2022 - Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart malformation accounting for ~10% of cases. Although the pathogenesis of TOF is complex and largely unknown, epigenetics plays a huge role, specifically DNA methylation. The protein δ like non‑canonical Notch ligand 1 (DLK1) gene encodes a non‑canonical ligand of the Notch signaling pathway, which is involved in heart develop...

Mapping health behaviour related to Chagas diagnosis in a non-endemic country: Applicat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775331
PloS One; Iglesias-Rus L, Romay-Barja M et. al.

Jan 21st, 2022 - Chagas disease has become a challenge for non-endemic countries since population mobility has increased in recent years and it has spread to these regions. In order to prevent vertical transmission and improve the prognosis of the disease, it is important to make an early diagnosis. And to develop strategies that improve access to diagnosis, it is important to know the factors that most influen...

Racial and Ethnic Disparities in Receipt of Medications for Treatment of COVID-19 - Uni...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774154
MMWR. Morbidity and Mortality Weekly Report; Wiltz JL, Feehan AK et. al.

Jan 21st, 2022 - The COVID-19 pandemic has magnified longstanding health care and social inequities, resulting in disproportionately high COVID-19-associated illness and death among members of racial and ethnic minority groups (1). Equitable use of effective medications (2) could reduce disparities in these severe outcomes (3). Monoclonal antibody (mAb) therapies against SARS-CoV-2, the virus that causes COVID-...

Identification and description of patients with multisystem inflammatory syndrome in ad...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886080
Epidemiology and Infection; DeCuir J, Baggs J et. al.

Jan 18th, 2022 - Multisystem inflammatory syndrome in adults (MIS-A) is a hyperinflammatory illness related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The characteristics of patients with this syndrome and the frequency with which it occurs among patients hospitalised after SARS-CoV-2 infection are unclear. Using the Centers for Disease Control and Prevention case definition for ...

Impact of a Novel, Low-Cost and Sustainable Health Education Program on the Knowledge, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832942
The American Journal of Tropical Medicine and Hygiene; Spencer SA, Andriamasy EH et. al.

Jan 11th, 2022 - Schistosomiasis control requires multisectoral approaches including praziquantel treatment, access to safe water, sanitation and hygiene, and health education. Community input can help ensure health education programs are culturally appropriate to effectively direct protective behavior change. This study reports on the three-stage development of an education program for Malagasy children, with ...

A meta-analysis of clinical manifestations in asian systemic lupus erythematous: The ef...
https://doi.org/10.1016/j.semarthrit.2021.12.004
Seminars in Arthritis and Rheumatism; Lee MH, Koh JWH et. al.

Jan 9th, 2022 - Systemic lupus erythematosus (SLE) in Asians is a unique patient group that has been thought to present with more severe organ involvement in comparison to their non-Asian counterparts. We set out to perform a meta-analysis to compare clinical manifestations between ancestries, with a focus on Southeast Asian ethnicities and gender. A cross-sectional study was performed in conjunction with a me...

The role of p.Val444Ala variant in the ABCB11 gene and susceptibility to biliary atresi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615439
Medicine Van Tung N, Lien NTK et. al.

Dec 30th, 2021 - Biliary atresia (BA) is the most serious type of obstructive cholangiopathy that occurs in infants. BA can be the cause of death in children under 2 years if untreated early. However, the etiology of the disease is not known. BA is considered to be the result of the destruction of the bile duct system including the accumulation of bile acids. The bile salt export pump, a transporter protein enc...

A novel compound heterozygous COL4A4 mutation in a Chinese family with Alport syndrome:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615339
Medicine Chen JY, Cui JJ et. al.

Dec 30th, 2021 - Alport syndrome (AS) is an inherited progressive renal failure, characterized by kidney disease, hearing loss, and eye abnormalities. A 7-year-old male child was admitted for persistent microscopic hematuria and proteinuria. Combined with clinical manifestations, laboratory testing, pathological changes of kidney and sequencing results, the patient was diagnosed as AS. The patient was treated w...

Response kinetics of different classes of antibodies to SARS-CoV2 infection in the Japa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687758
International Immunopharmacology; Kurano M, Morita Y et. al.

Dec 27th, 2021 - To better understand the immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with COVID-19, it is important to investigate the kinetics of the antibody responses and their associations with the clinical course in different populations, since there seem to be considerable differences between Western and Asian populations in the clinical featu...

Association between first language and SARS-CoV-2 infection rates, hospitalization, int...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482016
Clinical Microbiology and Infection : the Official Public... Holmberg V, Salmi H et. al.

Dec 25th, 2021 - Motivated by reports of increased risk of coronavirus disease 2019 (COVID-19) in ethnic minorities of high-income countries, we explored whether patients with a foreign first language are at an increased risk of COVID-19 infections, more serious presentations, or worse outcomes. In a retrospective observational population-based quality registry study covering a population of 1.7 million, we stu...

Staying moving, staying strong: Protocol for developing culturally appropriate informat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699613
PloS One; O'Brien P, Conley B et. al.

Dec 24th, 2021 - Addressing disparities in arthritis care is an important yet unmet health need for Aboriginal and Torres Strait Islander people in Australia (respectfully Aboriginal people herewith). Despite the significant prevalence and burden of arthritis within Aboriginal communities, access to care for arthritis is low. One means to reduce existing disparities in health care is to address current challeng...