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About 8,990 results

Disparities and Temporal Trends in COVID-19 Exposures and Mitigating Behaviors Among Bl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479580
JAMA Network Open; Badri S, Sardá V et. al.

Sep 29th, 2021 - COVID-19, caused by SARS-CoV-2 virus, has disproportionately affected Black and Hispanic communities in the US, which can be attributed to social factors including inconsistent public health messaging and suboptimal adoption of prevention efforts. To identify behaviors and evaluate trends in COVID-19-mitigating practices in a predominantly Black and Hispanic population, to identify differences ...

The risk and prognostic factors for brain metastases in esophageal cancer patients: an ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465786
BMC Cancer; Cheng S, Yang L et. al.

Sep 27th, 2021 - Brain metastases were rare in esophageal cancer patients. Using the Surveillance, Epidemiology, and End Results (SEER) database, the present study investigated the incidence, risk and prognostic factors of brain metastases in esophageal cancer patients. Retrieving esophageal cancer patients diagnosed between 2010 and 2018 from the SEER database, univariable and multivariable logistic and cox re...

Prospective observational study on Pazopanib in patients treated for advanced or metast...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442269
BMC Cancer; Erman M, Biswas B et. al.

Sep 16th, 2021 - Clinical effectiveness and safety data of pazopanib in patients with advanced or mRCC in real-world setting from Asia Pacific, North Africa, and Middle East countries are lacking. PARACHUTE is a phase IV, prospective, non-interventional, observational study. Primary endpoint was the proportion of patients remaining progression free at 12 months. Secondary endpoints were ORR, PFS, safety and tol...

Vaccination for SARS-CoV-2 of migrants and refugees, Jordan.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381092
Bulletin of the World Health Organization; Bellizzi S, Aidyralieva C et. al.

Sep 4th, 2021 - Vaccination for SARS-CoV-2 of migrants and refugees, Jordan.|2021|Bellizzi S,Aidyralieva C,Alsawhala L,Al-Shaikh A,Santoro A,|epidemiology,prevention & control,epidemiology,ethnology,

Prognostic significance of human papillomavirus 16 viral load level in patients with or...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486212
Cancer Science; Hashida Y, Higuchi T et. al.

Aug 13th, 2021 - Human papillomavirus (HPV) infection in patients with oropharyngeal squamous cell carcinoma (OPSCC) is a major determinant for better prognosis. However, there remain HPV-positive patients who have poor outcomes. The stratification strategy for detecting high-risk patients among those with HPV-positive OPSCC has not been well delineated, especially for Asian patients. We undertook a retrospecti...

Increasing SARS-CoV-2 vaccination rates among Black people in Canada.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367428
CMAJ : Canadian Medical Association Journal = Journal De ... Eissa A, Lofters A et. al.

Aug 11th, 2021 - Increasing SARS-CoV-2 vaccination rates among Black people in Canada.|2021|Eissa A,Lofters A,Akor N,Prescod C,Nnorom O,|ethnology,prevention & control,epidemiology,methods,statistics & numerical data,statistics & numerical data,

A comprehensive analysis of the efficacy and safety of COVID-19 vaccines.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342868
Molecular Therapy : the Journal of the American Society O... Cai C, Peng Y et. al.

Aug 9th, 2021 - The numbers of cases and deaths from coronavirus disease 2019 (COVID-19) are continuously increasing. Many people are concerned about the efficacy and safety of the COVID-19 vaccines. We performed a comprehensive analysis of the published trials of COVID-19 vaccines and the real-world data from the Vaccine Adverse Event Reporting System. Globally, our research found that the efficacy of all vac...

Metabolic syndrome and the risk of COVID-19 infection: A nationwide population-based ca...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158348
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD; Cho DH, Choi J et. al.

Aug 6th, 2021 - Metabolic syndrome (MetS) is a chronic, low-grade inflammatory disease. This study aimed to investigate the impact of MetS on the risk and severity of COVID-19. We investigated a nationwide cohort with COVID-19 including all patients who underwent the test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Korea. The COVID-19 group included 4070 patients with positive SARS-CoV-...

Risk factors for severity of COVID-19 in hospital patients age 18-29 years.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323903
PloS One; Sandoval M, Nguyen DT et. al.

Jul 31st, 2021 - Since February 2020, over 2.5 million Texans have been diagnosed with COVID-19, and 20% are young adults at risk for SARS-CoV-2 exposure at work, academic, and social settings. This study investigated demographic and clinical risk factors for severe disease and readmission among young adults 18-29 years old, who were diagnosed at a hospital encounter in Houston, Texas, USA. A retrospective regi...

Community SARS-CoV-2 Surge and Within-School Transmission.
https://doi.org/10.1542/peds.2021-052686
Pediatrics Zimmerman KO, Brookhart MA et. al.

Jul 30th, 2021 - When the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic began, experts raised concerns about in-person instruction in the setting of high levels of community transmission. We describe secondary transmission of SARS-CoV-2 within North Carolina kindergarten through 12th-grade school districts during a winter surge to determine if mitigation strategies can hinder within-scho...

Lower serum 25(OH)D levels associated with higher risk of COVID-19 infection in U.S. Bl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315514
PloS One; Cozier YC, Castro-Webb N et. al.

Jul 28th, 2021 - Limited evidence suggests that higher levels of serum vitamin D (25(OH)D) protect against SARS-CoV-2 virus (COVID-19) infection. Black women commonly experience 25(OH)D insufficiency and are overrepresented among COVID-19 cases. We conducted a prospective analysis of serum 25(OH)D levels in relation to COVID-19 infection among participants in the Black Women's Health Study. Since 1995, the Blac...

Differential disease phenotypes and progression in relapsing-remitting multiple scleros...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314572
BMC Neurology; Alluqmani M, Roda W et. al.

Jul 28th, 2021 - Relapsing-remitting multiple sclerosis (RR-MS) phenotypes differ widely although the variables contributing to this heterogeneity remain uncertain. To assess geographic and ethnic effects on RR-MS phenotypes, we investigated RR-MS patients in Canada and Saudi Arabia. A retrospective analysis of patients followed in two MS Clinics was performed in Medina, Saudi Arabia and Edmonton, Canada. Demog...

Longer Axial Length Potentiates Relationship of Intraocular Pressure and Peripapillary ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322720
Investigative Ophthalmology & Visual Science; Juliano J, Burkemper B et. al.

Jul 27th, 2021 - The purpose of this study was to investigate how axial length (AL) changes the relationship of intraocular pressure (IOP) with peripapillary vessel density (pVD) in glaucoma versus non-glaucomatous eyes. A population-based, cross-sectional study of 2127 African Americans aged 40 years and older in Inglewood, California, were imaged with 6 × 6-mm optic disc optical coherence tomography angiograp...

The synchronicity of COVID-19 disparities: Statewide epidemiologic trends in SARS-CoV-2...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301667
PloS One; Dixon BE, Grannis SJ et. al.

Jul 24th, 2021 - Early studies on COVID-19 identified unequal patterns in hospitalization and mortality in urban environments for racial and ethnic minorities. These studies were primarily single center observational studies conducted within the first few weeks or months of the pandemic. We sought to examine trends in COVID-19 morbidity, hospitalization, and mortality over time for minority and rural population...

Clinical significance of YAP1 and TAZ in esophageal squamous cell carcinoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284757
Medicine Liu L, Lu Z et. al.

Jul 15th, 2021 - Esophageal cancer is the eighth most frequent and sixth most fatal cancer worldwide. This study aimed to investigate the clinical characteristics and prognostic significance of yes related protein 1 (YAP1) and transcriptional co-activator with PDZ binding motif (TAZ) in patients with esophageal squamous cell carcinoma (ESCC). A total of 306 ESCC pathological specimens and adjacent tissues (as c...

Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279307
PloS One; Davis G, York AJ et. al.

Jul 15th, 2021 - The world is currently in a pandemic of COVID-19 (Coronavirus disease-2019) caused by a novel positive-sense, single-stranded RNA β-coronavirus referred to as SARS-CoV-2. Here we investigated rates of SARS-CoV-2 infection in the greater Cincinnati, Ohio, USA metropolitan area from August 13 to December 8, 2020, just prior to initiation of the national vaccination program. Examination of 9,550 a...

Identification of variants of ISL1 gene promoter and cellular functions in isolated ven...
https://doi.org/10.1152/ajpcell.00167.2021
American Journal of Physiology. Cell Physiology; Zheng SQ, Chen HX et. al.

Jul 15th, 2021 - Ventricular septal defects (VSDs) are the most common congenital heart defects (CHDs). Studies have documented that ISL1 has a crucial impact on cardiac growth, but the role of variants in the ISL1 gene promoter in patients with VSD has not been explored. In 400 subjects (200 patients with isolated and sporadic VSDs: 200 healthy controls), we investigated the ISL1 gene promoter variant and perf...

Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection A...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278272
JAMA Network Open; Bennett TD, Moffitt RA et. al.

Jul 14th, 2021 - The National COVID Cohort Collaborative (N3C) is a centralized, harmonized, high-granularity electronic health record repository that is the largest, most representative COVID-19 cohort to date. This multicenter data set can support robust evidence-based development of predictive and diagnostic tools and inform clinical care and policy. To evaluate COVID-19 severity and risk factors over time a...

Multiple myeloma, race, insurance and treatment.
https://doi.org/10.1016/j.canep.2021.101974
Cancer Epidemiology; Joshi H, Lin S et. al.

Jul 10th, 2021 - Multiple Myeloma (MM), the second leading blood malignancy, has complex and costly disease management. We studied patterns of treatment disparities and unplanned interruptions among the MM patients after the Affordable Care Act to assess their prevalence and effect on survival. This retrospective study of 1002 MM patients at a tertiary referral center used standard guidelines as a reference to ...

Comorbidities, sequelae, blood biomarkers and their associated clinical outcomes in the...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260001
PloS One; Brojakowska A, Eskandari A et. al.

Jul 7th, 2021 - With the continuing rise of SARS-CoV2 infection globally and the emergence of various waves in different countries, understanding characteristics of susceptibility to infection, clinical severity, and outcomes remain vital. In this retrospective study, data was extracted for 39,539 patients from the de-identified Mount Sinai Health System COVID-19 database. We assessed the risk of mortality bas...