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About 9,695 results

Geographic and Racial Disparities in Access to Chimeric Antigen Receptor-T Cells and Bi...
https://doi.org/10.1001/jamanetworkopen.2022.28877
JAMA Network Open; Alqazaqi R, Schinke C et. al.

Aug 27th, 2022 - The use of chimeric antigen receptor-T cell (CAR-T) therapy and bispecific antibodies in multiple myeloma is expanding, with encouraging early results. It is unknown if the current geographic distribution of CAR-T therapy and bispecific antibodies in multiple myeloma allows access for patients in need, especially for Black populations, which have a higher incidence of multiple myeloma. To inves...

Disparities in trial enrollment and outcomes of Hispanic adolescent and young adult acu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327550
Blood Advances; Muffly L, Yin J et. al.

Jul 16th, 2022 - In this secondary analysis of Hispanic adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) treated on Cancer and Leukemia Group B (CALGB) 10403, we evaluated outcomes and geographic enrollment patterns relative to US population data. We used demographic, clinical, and survival data on AYAs enrolled on CALGB 10403 (N = 295, 2007-2012). Surveillance, Epidemiology, and End R...

Trends in Cancer Mortality Among Black Individuals in the US From 1999 to 2019.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121301
JAMA Oncology; Lawrence WR, McGee-Avila JK et. al.

May 20th, 2022 - Cancer is the second leading cause of mortality in the US. Despite national decreases in cancer mortality, Black individuals continue to have the highest cancer death rates. To examine national trends in cancer mortality from 1999 to 2019 among Black individuals by demographic characteristics and to compare cancer death rates in 2019 among Black individuals with rates in other racial and ethnic...

Enrollment of Black Participants in Pivotal Clinical Trials Supporting US Food and Drug...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021907
JAMA Network Open; Al Hadidi S, Schinke C et. al.

Apr 21st, 2022 - Disparities that affect Black persons with various hematological malignant neoplasms are substantial, yet little is known about disparities related to the use of US Food and Drug Administration (FDA)-approved chimeric antigen receptor-T cell (CAR-T) therapy. To examine the enrollment of Black participants in clinical trials that resulted in a subsequent FDA approval of CAR-T products in hematol...

COVID-19-Associated Hospitalizations Among Adults During SARS-CoV-2 Delta and Omicron V...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956338
MMWR. Morbidity and Mortality Weekly Report; Taylor CA, Whitaker M et. al.

Mar 25th, 2022 - Beginning the week of December 19-25, 2021, the B.1.1.529 (Omicron) variant of SARS-CoV-2 (the virus that causes COVID-19) became the predominant circulating variant in the United States (i.e., accounted for >50% of sequenced isolates).* Information on the impact that booster or additional doses of COVID-19 vaccines have on preventing hospitalizations during Omicron predominance is limited. Dat...

Eligibility Criteria Perpetuate Disparities in Enrollment and Participation of Black Pa...
https://doi.org/10.1200/JCO.21.02492
Journal of Clinical Oncology : Official Journal of the Am... Riner AN, Girma S et. al.

Mar 23rd, 2022 - Clinical trials determine safety and efficacy of cancer therapeutics and establish standards of care. Minority patient participation in cancer clinical trials is dismal. We aimed to determine the impact of eligibility criteria on disparities in pancreatic ductal adenocarcinoma (PDAC) clinical trial candidacy. Traditional PDAC trial eligibility criteria were obtained from ClinicalTrials.gov. Pat...

Phase 2 Trial of Iberdomide in Systemic Lupus Erythematosus.
https://doi.org/10.1056/NEJMoa2106535
The New England Journal of Medicine; Merrill JT, Werth VP et. al.

Mar 17th, 2022 - Iberdomide, a cereblon modulator promoting degradation of the transcription factors Ikaros and Aiolos, which affect leukocyte development and autoimmunity, is being evaluated for the treatment of systemic lupus erythematosus (SLE). In this phase 2 trial, we randomly assigned patients in a 2:2:1:2 ratio to receive oral iberdomide (at a dose of 0.45, 0.30, or 0.15 mg) or placebo once daily for 24...

Hospitalizations and Mortality From Non-SARS-CoV-2 Causes Among Medicare Beneficiaries ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908076
JAMA Network Open; Dang A, Thakker R et. al.

Mar 10th, 2022 - The increased hospital mortality rates from non-SARS-CoV-2 causes during the SARS-CoV-2 pandemic are incompletely characterized. To describe changes in mortality rates after hospitalization for non-SARS-CoV-2 conditions during the COVID-19 pandemic and how mortality varies by characteristics of the admission and hospital. Retrospective cohort study from January 2019 through September 2021 using...

Tumor molecular differences associated with outcome disparities of Black patients with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047510
Head & Neck; Kim HAJ, Zeng PYF et. al.

Feb 22nd, 2022 - Numerous studies of head and neck squamous cell carcinoma (HNSCC) have demonstrated disparate outcomes by race and ethnicity. Beyond known associations with socioeconomic variables, whether these are also associated with differences in tumor molecular composition has thus far been poorly explored. We downloaded clinical and multiplatform molecular data from The Cancer Genome Atlas and other pub...

The genetic landscape of pancreatic head ductal adenocarcinoma in China and prognosis s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855595
BMC Cancer; Yang Y, Ding Y et. al.

Feb 20th, 2022 - Pancreatic ductal adenocarcinoma (PDAC) is the major subtype of pancreatic cancer and head PDACs show distinct characteristics from body/tail PDACs. With limited studies based on Asian population, the mutational landscape of Asian PDAC remains unclear. One hundred fifty-one Chinese patients with head PDAC were selected and underwent targeted 425-gene sequencing. Genomic alterations, tumor mutat...

Comparison of Racial, Ethnic, and Geographic Location Diversity of Participants Enrolle...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844998
JAMA Network Open; Stewart J, Krows ML et. al.

Feb 15th, 2022 - Racial and ethnic diversity among study participants is associated with improved generalizability of clinical trial results and may address inequities in evidence that informs public health strategies. Novel strategies are needed for equitable access and recruitment of diverse clinical trial populations. To investigate demographic and geographical location data for participants in 2 remote COVI...

Racial/ethnic disparities in hepatocellular carcinoma incidence and mortality rates in ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352816
Hepatology (Baltimore, Md.); Alvarez CS, Petrick JL et. al.

Feb 7th, 2022 - HCC is characterized by racial/ethnic disparities in rates. Recent USA reports suggest that incidence has begun to decline, but it is not clear whether the declines have occurred among all groups, nor whether mortality has declined. Thus, the current study examined USA incidence and mortality between 1992 and 2018. HCC incidence and incidence-based mortality data from the Surveillance, Epidemio...

Using dipstick urinalysis to predict development of acute kidney injury in patients wit...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805668
BMC Nephrology; McAdams MC, Li M et. al.

Feb 3rd, 2022 - Acute kidney injury (AKI) is a common complication in patients hospitalized with COVID-19 and may require renal replacement therapy (RRT). Dipstick urinalysis is frequently obtained, but data regarding the prognostic value of hematuria and proteinuria for kidney outcomes is scarce. Patients with positive severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) PCR, who had a urinalysis obtai...

Prevalence and Cumulative Risk of Familial Idiopathic Dilated Cardiomyopathy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808323
JAMA Huggins GS, Kinnamon DD et. al.

Feb 2nd, 2022 - Idiopathic dilated cardiomyopathy (DCM) aggregates in families, and early detection in at-risk family members can provide opportunity to initiate treatment prior to late-phase disease. Most studies have included only White patients, yet Black patients with DCM have higher risk of heart failure-related hospitalization and death. To estimate the prevalence of familial DCM among DCM probands and t...

Cutaneous leishmaniasis in a 12-year-old Syrian immigrant.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900756
CMAJ : Canadian Medical Association Journal = Journal De ... Alghounaim M, Chivinski J et. al.

Jan 26th, 2022 - Cutaneous leishmaniasis in a 12-year-old Syrian immigrant.|2022|Alghounaim M,Chivinski J,Barkati S,|therapeutic use,therapeutic use,diagnosis,drug therapy,pathology,ethnology,

CpG site hypomethylation at ETS1‑binding region regulates DLK1 expression in Chinese pa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809049
Molecular Medicine Reports; Tian G, He L et. al.

Jan 22nd, 2022 - Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart malformation accounting for ~10% of cases. Although the pathogenesis of TOF is complex and largely unknown, epigenetics plays a huge role, specifically DNA methylation. The protein δ like non‑canonical Notch ligand 1 (DLK1) gene encodes a non‑canonical ligand of the Notch signaling pathway, which is involved in heart develop...

Mapping health behaviour related to Chagas diagnosis in a non-endemic country: Applicat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775331
PloS One; Iglesias-Rus L, Romay-Barja M et. al.

Jan 21st, 2022 - Chagas disease has become a challenge for non-endemic countries since population mobility has increased in recent years and it has spread to these regions. In order to prevent vertical transmission and improve the prognosis of the disease, it is important to make an early diagnosis. And to develop strategies that improve access to diagnosis, it is important to know the factors that most influen...

Racial and Ethnic Disparities in Receipt of Medications for Treatment of COVID-19 - Uni...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774154
MMWR. Morbidity and Mortality Weekly Report; Wiltz JL, Feehan AK et. al.

Jan 21st, 2022 - The COVID-19 pandemic has magnified longstanding health care and social inequities, resulting in disproportionately high COVID-19-associated illness and death among members of racial and ethnic minority groups (1). Equitable use of effective medications (2) could reduce disparities in these severe outcomes (3). Monoclonal antibody (mAb) therapies against SARS-CoV-2, the virus that causes COVID-...

Identification and description of patients with multisystem inflammatory syndrome in ad...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886080
Epidemiology and Infection; DeCuir J, Baggs J et. al.

Jan 18th, 2022 - Multisystem inflammatory syndrome in adults (MIS-A) is a hyperinflammatory illness related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The characteristics of patients with this syndrome and the frequency with which it occurs among patients hospitalised after SARS-CoV-2 infection are unclear. Using the Centers for Disease Control and Prevention case definition for ...

Impact of a Novel, Low-Cost and Sustainable Health Education Program on the Knowledge, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832942
The American Journal of Tropical Medicine and Hygiene; Spencer SA, Andriamasy EH et. al.

Jan 11th, 2022 - Schistosomiasis control requires multisectoral approaches including praziquantel treatment, access to safe water, sanitation and hygiene, and health education. Community input can help ensure health education programs are culturally appropriate to effectively direct protective behavior change. This study reports on the three-stage development of an education program for Malagasy children, with ...