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About 211,634 results

Risk factors and outcomes for acute respiratory failure in coronavirus disease 2019: An...
https://doi.org/10.17219/acem/130603
Advances in Clinical and Experimental Medicine : Official... Piwowarczyk P, Szczukocka M et. al.

Dec 31st, 2020 - The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread throughout Europe. However, there is a lack of data on the full clinical course of patients infected with SARS-CoV-2 in Europe, especially in the population that developed acute respiratory failure (ARF). To identify risk factors associated with developing ARF during SARS-CoV-2 infection. This was an observationa...

Effect of acetazolamide on visual function in patients with idiopathic intracranial hyp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362615
JAMA , Wall M et. al.

Apr 23rd, 2014 - Acetazolamide is commonly used to treat idiopathic intracranial hypertension (IIH), but there is insufficient information to establish an evidence base for its use. To determine whether acetazolamide is beneficial in improving vision when added to a low-sodium weight reduction diet in patients with IIH and mild visual loss. Multicenter, randomized, double-masked, placebo-controlled study of ace...

Rosuvastatin for sepsis-associated acute respiratory distress syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241052
The New England Journal of Medicine; , Truwit JD et. al.

May 19th, 2014 - In the acute respiratory distress syndrome (ARDS), inflammation in the lungs and other organs can cause life-threatening organ failure. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) can modulate inflammatory responses. Previous observational studies suggested that statins improved clinical outcomes in patients with sepsis. We hypothesized that rosuvastatin therapy woul...

Long-term ultraviolet flux, other potential risk factors, and skin cancer risk: a cohor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151553
Cancer Epidemiology, Biomarkers & Prevention : a Publicat... Wu S, Han J et. al.

May 30th, 2014 - Few prospective studies have examined the relationship between sun exposure, other potential risk factors, and risk of different skin cancers [including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma] simultaneously. We evaluated the association between a number of potential risk factors and skin cancer risk in a cohort of 108,916 US women, the Nurses' Health Study II (...

Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698790
JAMA Hsieh MM, Fitzhugh CD et. al.

Jul 24th, 2014 - Myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) is curative for children with severe sickle cell disease, but toxicity may be prohibitive for adults. Nonmyeloablative transplantation has been attempted with degrees of preparative regimen intensity, but graft rejection and graft-vs-host disease remain significant. To determine the efficacy, safety, and outcome on end-orga...

Contributions of the social environment to first-onset and recurrent mania.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206672
Molecular Psychiatry; Gilman SE, Ni MY et. al.

Apr 22nd, 2014 - In treated cohorts, individuals with bipolar disorder are more likely to report childhood adversities and recent stressors than individuals without bipolar disorder; similarly, in registry-based studies, childhood adversities are more common among individuals who later become hospitalized for bipolar disorder. Because these types of studies rely on treatment-seeking samples or hospital diagnose...

Nonselective β blockers increase risk for hepatorenal syndrome and death in patients wi...
https://doi.org/10.1053/j.gastro.2014.03.005
Gastroenterology Mandorfer M, Bota S et. al.

Mar 18th, 2014 - Nonselective β blockers (NSBBs) reduce portal pressure and the risk for variceal hemorrhage in patients with cirrhosis. However, development of spontaneous bacterial peritonitis (SBP) in these patients could preclude treatment with NSBBs because of their effects on the circulatory reserve. We investigated the effects of NSBBs in patients with cirrhosis and ascites with and without SBP. We perfo...

Actionable diagnosis of neuroleptospirosis by next-generation sequencing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134948
The New England Journal of Medicine; Wilson MR, Naccache SN et. al.

Jun 4th, 2014 - A 14-year-old boy with severe combined immunodeficiency presented three times to a medical facility over a period of 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically induced coma. Diagnostic workup including brain biopsy was unrevealing. Unbiased next-generation sequencing of the cerebrospinal fluid identified 475 of 3,063,784 se...

Early lung ultrasonography predicts the occurrence of acute respiratory distress syndro...
https://doi.org/10.1007/s00134-014-3382-9
Intensive Care Medicine; Leblanc D, Bouvet C et. al.

Jul 15th, 2014 - Extent of lung contusion on initial computed tomography (CT) scan predicts the occurrence of acute respiratory distress syndrome (ARDS) in blunt chest trauma patients. We hypothesized that lung ultrasonography (LUS) on admission could also predict subsequent ARDS. Forty-five blunt trauma patients were prospectively studied. Clinical examination, chest radiography, and LUS were performed on arri...

Inhibition of the mTORC pathway in the antiphospholipid syndrome.
https://doi.org/10.1056/NEJMoa1312890
The New England Journal of Medicine; Canaud G, Bienaimé F et. al.

Jul 23rd, 2014 - Although thrombosis is considered the cardinal feature of the antiphospholipid syndrome, chronic vascular lesions are common, particularly in patients with life-threatening complications. In patients who require transplantation, vascular lesions often recur. The molecular pathways involved in the vasculopathy of the antiphospholipid syndrome are unknown, and adequate therapies are lacking. We u...

Review article: the management of portal hypertensive gastropathy and gastric antral va...
https://doi.org/10.1111/apt.12824
Alimentary Pharmacology & Therapeutics; Patwardhan VR, Cardenas A

Jun 3rd, 2014 - Portal hypertensive gastropathy (PHG) and gastric antral vascular ectasia (GAVE) are important causes of both acute and chronic gastrointestinal bleeding in patients with cirrhosis. To review the current management of PHG and GAVE. PubMed was searched for English language articles using the key words 'GAVE', 'gastric antral vascular ectasia', 'cirrhosis', 'gastrointestinal bleeding', 'acute', '...

Prenatal antidepressant exposure is associated with risk for attention-deficit hyperact...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427538
Molecular Psychiatry; Clements CC, Castro VM et. al.

Aug 26th, 2014 - Previous studies suggested that risk for Autism Spectrum Disorder (ASD) may be increased in children exposed to antidepressants during the prenatal period. The disease specificity of this risk has not been addressed and the possibility of confounding has not been excluded. Children with ASD or attention-deficit hyperactivity disorder (ADHD) delivered in a large New England health-care system we...

Causes of pulmonary hypertension in the elderly.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077408
Chest Pugh ME, Sivarajan L et. al.

Jan 31st, 2014 - Pulmonary hypertension (PH) is common in elderly patients, but a detailed analysis of the causes of PH in the elderly has not been performed. We hypothesized that pulmonary arterial hypertension (PAH) is rare in elderly patients and sought to describe the characteristics of these patients at a large referral center. Clinical and hemodynamic data were collected on consecutive patients ≥ 65 years...

Simvastatin in the acute respiratory distress syndrome.
https://doi.org/10.1056/NEJMoa1403285
The New England Journal of Medicine; McAuley DF, Laffey JG et. al.

Sep 30th, 2014 - Studies in animals and in vitro and phase 2 studies in humans suggest that statins may be beneficial in the treatment of the acute respiratory distress syndrome (ARDS). This study tested the hypothesis that treatment with simvastatin would improve clinical outcomes in patients with ARDS. In this multicenter, double-blind clinical trial, we randomly assigned (in a 1:1 ratio) patients with an ons...

Dalfampridine may activate latent trigeminal neuralgia in patients with multiple sclero...
https://doi.org/10.1212/WNL.0000000000000931
Neurology Birnbaum G, Iverson J

Sep 27th, 2014 - To determine the effect of dalfampridine (4-aminopyridine), a broad-spectrum, voltage-dependent potassium channel blocker, on patients with trigeminal nerve dysfunction due to multiple sclerosis (MS). We reviewed histories of 71 patients in our clinic with clinically definite MS who were treated with dalfampridine for at least 2 to 3 months. Of the 71 patients, 5 had a history of either trigemi...

The incidence of visual impairment due to retinopathy of prematurity (ROP) and concomit...
https://doi.org/10.1136/bjo.2010.192542
The British Journal of Ophthalmology; van Sorge AJ, Termote JU et. al.

Feb 11th, 2011 - To determine the incidence of visual impairment (VI) caused by retinopathy of prematurity (ROP) and concomitant disabilities in preterm neonates born between 2000 and 2009 in the Netherlands. Data were retrieved from the Dutch institutes for the visually impaired. They were compared with similar Dutch studies conducted in 1975-1987, 1986-1994 and 1994-2000. Records of 42 infants with VI due to ...

Mycophenolate versus azathioprine as maintenance therapy for lupus nephritis.
https://doi.org/10.1056/NEJMoa1014460
The New England Journal of Medicine; Dooley MA, Jayne D et. al.

Nov 17th, 2011 - Maintenance therapy, often with azathioprine or mycophenolate mofetil, is required to consolidate remission and prevent relapse after the initial control of lupus nephritis. We carried out a 36-month, randomized, double-blind, double-dummy, phase 3 study comparing oral mycophenolate mofetil (2 g per day) and oral azathioprine (2 mg per kilogram of body weight per day), plus placebo in each grou...

Moving toward "laboratory-supported" criteria for psychogenic tremor.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664413
Movement Disorders : Official Journal of the Movement Dis... Schwingenschuh P, Katschnig P et. al.

Sep 30th, 2011 - A confident clinical diagnosis of psychogenic tremor is often possible, but, in some cases, a "laboratory-supported" level of certainty would aid in early positive diagnosis. Various electrophysiological tests have been suggested to identify patients with psychogenic tremor, but their diagnostic reliability has never been assessed "head to head" nor compared to forms of organic tremor other tha...

Three-dimensional echocardiographic assessment of right ventricular volume and function...
https://doi.org/10.1016/j.echo.2009.11.002
Journal of the American Society of Echocardiography : Off... Grewal J, Majdalany D et. al.

Dec 7th, 2009 - The aim of this study was to evaluate the accuracy of three-dimensional (3D) ultrasound compared with the standard magnetic resonance imaging method in determining right ventricular (RV) volumes and function in adult patients with congenital heart disease and chronic, severe pulmonary regurgitation (PR). Twenty-five patients with severe PR secondary to either pulmonary valvotomy or tetralogy of...

Adrenocortical carcinoma and pregnancy: clinical and biological features and prognosis.
https://doi.org/10.1530/EJE-10-0412
European Journal of Endocrinology; Abiven-Lepage G, Coste J et. al.

Aug 11th, 2010 - Adrenocortical carcinoma (ACC) is a rare, severe disease. Pregnancy-associated ACC has rarely been reported. We wished to evaluate the characteristics and prognosis of ACC diagnosed in patients during pregnancy or in the postpartum period, comparing them with those for ACC diagnosed in nonpregnant women. Clinical presentation, hormonal secretion, staging, survival, and obstetric data are report...