Jan 16th, 2022 - WAIKOLOA, Hawaii — It is important for physicians to consider “the perils that dwell” in the diagnostic management of patients with uveitis, Steven Yeh, MD, said during a presentation at Hawaiian Eye 2022. “With these patients being very complex oftentimes, we really just don’t want to miss something,” Yeh said. To better identify “the pearls amongst the perils” in uveitis diagnosis, it is impo...
May 13th, 2021 - WAILEA, Hawaii — Glaucoma patients may ask for ways to monitor IOP between visits, but ophthalmologists should weigh benefits and drawbacks of at-home monitoring options, according to speakers at Hawaiian Eye 2021. “I have that question all the time, actually,” Sahar Bedrood, MD, PhD, said. “Some of my patients are significantly worried, so they come in.” Options for at-home eye care include re...
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Clinical Rheumatology; Bilberg A, Larsson I et. al.
Jun 2nd, 2022 - To evaluate the effects of weight loss treatment on physical fitness in patients with psoriatic arthritis (PsA) and obesity compared to matched controls. In total, 46 patients with PsA (CASPAR) and BMI ≥ 33 kg/m2 and 52 obese persons were included in this 12-month prospective open intervention study with a very low energy diet (640 kcal/day), followed by structured reintroduction of an energy-r...
The Lancet Child & Adolescent Health; Mensah AA, .
Jun 29th, 2022 - Reinfection after primary SARS-CoV-2 infection is uncommon in adults, but little is known about the risks, characteristics, severity, or outcomes of reinfection in children. We aimed to assess the risk of SARS-CoV-2 reinfection in children and compare this with the risk in adults, by analysis of national testing data for England.
Emerging Infectious Diseases; Matsumura Y, Nagao M et. al.
Jun 17th, 2022 - Household transmission is a primary source of SARS-CoV-2 spread. We used COVID-19 epidemiologic investigation data and viral genome analysis data collected in the city of Kyoto, Japan, during January 2020–June 2021 to evaluate the effects of different settings and viral strains on SARS-CoV-2 transmission. Epidemiologic investigations of 5,061 COVID-19 cases found that the most common category f...
NEJM Journal Watch; Calderon AJ.
Jun 9th, 2022 - Guidelines written in 2021 recommend prone positioning in awake patients with COVID-19 who require supplemental oxygen (Crit Care 2021; 25:106. opens in new tab). These guidelines were based on limited evidence that proning can improve oxygenation and on extrapolation of data from ventilated patients with acute respiratory distress syndrome, where early and prolonged proning limits mortality.
World Health Organization (WHO)
Mar 21st, 2022 - The Updated guidelines on Management of tuberculosis in children and adolescents include new recommendations that cover diagnostic approaches for TB, shorter treatment for children with non-severe drug-susceptible TB, a new option for the treatment of TB meningitis, the use of bedaquiline and delamanid in young children with multidrug- and rifampicin-resistant TB and decentralized and family-ce...
Jul 1st, 2022 - For Immediate Release: July 01, 2022 Today, the U.S. Food and Drug Administration is providing an at-a-glance summary of news from around the agency: Today, the FDA announced a request for nominations for consumer representatives to serve on advisory committees and panels for which vacancies currently exist or are expected to occur in the near future. The FDA relies on our many advisory committ...
Jodie Barkin, MD,, MDedge News
Jul 1st, 2022 - What characteristics or symptoms do you look for to identify patients who are at risk for exocrine pancreatic insufficiency (EPI)? Dr. Barkin: The first thing we have to understand is which patient populations we should consider.
Jun 30th, 2022 - For the first time, the American Society for Clinical Oncology (ASCO) has released guidelines for the treatment of metastatic clear cell renal cell carcinoma. This year in the U.
Jun 30th, 2022 - For Immediate Release: June 30, 2022 Statement From: Peter Marks, M.D., PhD. Director - Center for Biologics Evaluation and Research (CBER) On Tuesday, the U.S. Food and Drug Administration’s independent experts on the Vaccines and Related Biological Products Advisory Committee met to publicly discuss whether a change to the current vaccine strain composition of COVID-19 vaccines for booster do...
Journal of Inherited Metabolic Disease; Venturoni LE, Venditti CP
Jun 30th, 2022 - Hereditary methylmalonic acidemia (MMA) caused by deficiency of the enzyme methylmalonyl-CoA mutase (MMUT) is a relatively common and severe organic acidemia. The recalcitrant nature of the condition to conventional dietary and medical management has led to the use of elective liver and combined liver-kidney transplantation in some patients. However, liver transplantation is intrinsically limit...
American Journal of Epidemiology; Klipstein S, Dionne JA et. al.
Jun 30th, 2022 - A recent study by Wesselink et al. (Am J Epidemiol. 2022;191(XX):XXXX-XXXX) adds to the growing body of research finding that vaccination for coronavirus disease 2019 (COVID-19) is safe for individuals either seeking pregnancy or who are pregnant. The study's authors found no effect of COVID-19 vaccination on fecundity in a population of individuals with no known infertility who were attempting...
Annals of the American Thoracic Society; Carlens J, Johnson KT et. al.
Jun 30th, 2022 - Variable disease course and outcomes have been reported in Children's interstitial lung disease (ChILD) associated with Filamin A gene (FLNA) variants. To further delineate long term respiratory outcomes and identify potential contributing factors to severe disease course. We retrospectively collected longitudinal data from 3 centres on 9 cases (1 male) with FLNA variants and early respiratory ...
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World Journal of Surgery; Bouriez D, Gronnier C et. al.
Jun 30th, 2022 - Multiple endocrine neoplasia type 1 (MEN1)-associated primary hyperparathyroidism (pHPT) is classically associated with an asymmetric and asynchronous parathyroid involvement. Subtotal parathyroidectomy (STP), which is currently the recommended surgical treatment, carries a high risk of permanent hypoparathyroidism. The results of less than subtotal parathyroidectomy (LSTP) are conflicting, and...
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Annals of Surgical Oncology; Tseng WW, Swallow CJ et. al.
Jun 30th, 2022 - Surgery is the mainstay of treatment for retroperitoneal sarcoma (RPS), but local recurrence is common. Biologic behavior and recurrence patterns differ significantly among histologic types of RPS, with implications for management. The Transatlantic Australasian RPS Working Group (TARPSWG) published a consensus approach to primary RPS, and to complement this, one for recurrent RPS in 2016. Sinc...
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Endocrine Shi L, You Q et. al.
Jun 30th, 2022 - Management of progressive, metastatic radioactive iodine refractory differentiated thyroid cancer (RAIR-DTC) has been a great challenge due to its poor prognosis and limited treatment options. Recently, apatinib, an orally anti-angiogenic tyrosine kinase inhibitor (TKI) is reported to be useful for treatment of progressive RAIR-DIC. The aim of this study was to evaluate the antitumour effect of...
Endocrine Partenope C, Pozzobon G et. al.
Jun 30th, 2022 - We examined endocrine manifestations in a cohort of paediatric patients with IC-GCTs at diagnosis and during follow-up, integrating clinical, radiological, histopathological and laboratory data. Diabetes insipidus (DI), growth hormone deficiency (GHD), hypothyroidism, adrenal insufficiency, precocious puberty (PP)/hypogonadism were diagnosed clinically and biochemically. The prevalence of endoc...
Circulation. Heart Failure; Henriksen PA, Hall P et. al.
Jun 30th, 2022 - Anthracyclines are effective cytotoxic drugs used in the treatment of breast cancer and lymphoma but are associated with myocardial injury, left ventricular dysfunction, and heart failure. Anthracycline-induced cardiotoxicity is highly variable in severity and without a proven therapeutic intervention. β-Adrenergic receptor blockers and renin-angiotensin-system inhibitor therapies have been ass...
British Journal of Haematology; Shargian L, Raanani P et. al.
Jun 30th, 2022 - Treatment with high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is considered standard of care (SOC) second-line treatment for relapsed or refractory large B-cell lymphoma (LBCL). However, outcomes remain suboptimal. A systematic review and meta-analysis of randomised controlled trials comparing efficacy and safety of SOC versus chimeric antigen receptor T-cell (CA...