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About 512,128 results

How to avoid the perils of uveitis diagnostic management
https://www.healio.com/news/ophthalmology/20220116/how-to-avoid-the-perils-of-uveitis-diagnostic-management

Jan 16th, 2022 - WAIKOLOA, Hawaii — It is important for physicians to consider “the perils that dwell” in the diagnostic management of patients with uveitis, Steven Yeh, MD, said during a presentation at Hawaiian Eye 2022. “With these patients being very complex oftentimes, we really just don’t want to miss something,” Yeh said. To better identify “the pearls amongst the perils” in uveitis diagnosis, it is impo...

Weigh pros, cons of at-home IOP measurements
https://www.healio.com/news/ophthalmology/20210513/weigh-pros-cons-of-athome-iop-measurements

May 13th, 2021 - WAILEA, Hawaii — Glaucoma patients may ask for ways to monitor IOP between visits, but ophthalmologists should weigh benefits and drawbacks of at-home monitoring options, according to speakers at Hawaiian Eye 2021. “I have that question all the time, actually,” Sahar Bedrood, MD, PhD, said. “Some of my patients are significantly worried, so they come in.” Options for at-home eye care include re...

The impact of a structured weight-loss treatment on physical fitness in patients with p...
https://doi.org/10.1007/s10067-022-06164-5 10.1056/NEJMra1505557 10.1111/1756-185X.12283 10.1093/rheumatology/ker349 10.1080/03009742.2019.1672783 10.3899/jrheum.171034 10.2174/1574887113666180314105511 10.1136/annrheumdis-2014-206824 10.1161/CIRCRESAHA.115.306883 10.1016/j.mayocp.2018.01.016 10.1007/s11695-013-0924-0 10.1016/S0140-6736(16)00271-3 10.1046/j.1467-789x.2001.00026.x 10.1249/MSS.0000000000001074 10.1111/obr.12422 10.1016/j.archger.2016.02.004 10.1016/j.physio.2015.05.003 10.1136/ard.51.1.35 10.1186/s13075-019-1810-5 10.1186/s13075-020-02350-5 10.1002/art.21972 10.3109/03009749309095105 10.1016/0002-9343(85)90465-6 10.1152/jappl.1954.7.2.218 10.1186/1471-2474-15-305 10.1097/00005650-199206000-00002 10.1111/sms.12611 10.1002/art.23568 10.1136/ard.2009.122259 10.1146/annurev.nutr.21.1.323 10.1002/oby.22476 10.1016/j.bone.2009.10.013 10.1002/art.33394 10.1001/jama.2009.681 10.1080/00913847.2019.1623995 10.1016/j.semarthrit.2004.07.010 10.3945/an.116.014506 10.1007/s11926-012-0263-5 10.1002/acr.24126 10.7762/cnr.2019.8.2.148 10.1186/s12905-019-0864-5
Clinical Rheumatology; Bilberg A, Larsson I et. al.

Jun 2nd, 2022 - To evaluate the effects of weight loss treatment on physical fitness in patients with psoriatic arthritis (PsA) and obesity compared to matched controls. In total, 46 patients with PsA (CASPAR) and BMI ≥ 33 kg/m2 and 52 obese persons were included in this 12-month prospective open intervention study with a very low energy diet (640 kcal/day), followed by structured reintroduction of an energy-r...

Risk of SARS-CoV-2 reinfections in children: a prospective national surveillance study between January, 2020, and July, 2021, in England
https://www.sciencedirect.com/science/article/pii/S2352464222000591
The Lancet Child & Adolescent Health; Mensah AA, .

Jun 29th, 2022 - Reinfection after primary SARS-CoV-2 infection is uncommon in adults, but little is known about the risks, characteristics, severity, or outcomes of reinfection in children. We aimed to assess the risk of SARS-CoV-2 reinfection in children and compare this with the risk in adults, by analysis of national testing data for England.

Transmissibility of SARS-CoV-2 B.1.1.214 and Alpha Variants during 4 COVID-19 Waves, Kyoto, Japan, January 2020–June 2021
https://wwwnc.cdc.gov/eid/article/28/8/22-0420_article
Emerging Infectious Diseases; Matsumura Y, Nagao M et. al.

Jun 17th, 2022 - Household transmission is a primary source of SARS-CoV-2 spread. We used COVID-19 epidemiologic investigation data and viral genome analysis data collected in the city of Kyoto, Japan, during January 2020–June 2021 to evaluate the effects of different settings and viral strains on SARS-CoV-2 transmission. Epidemiologic investigations of 5,061 COVID-19 cases found that the most common category f...

Another Look at Proning in Nonintubated Hospitalized Patients with COVID-19
https://www.jwatch.org/na54864/2022/06/09/another-look-proning-nonintubated-hospitalized-patients
NEJM Journal Watch; Calderon AJ.

Jun 9th, 2022 - Guidelines written in 2021 recommend prone positioning in awake patients with COVID-19 who require supplemental oxygen (Crit Care 2021; 25:106. opens in new tab). These guidelines were based on limited evidence that proning can improve oxygenation and on extrapolation of data from ventilated patients with acute respiratory distress syndrome, where early and prolonged proning limits mortality.

WHO consolidated guidelines on tuberculosis Module 5: Management of tuberculosis in children and adolescents
https://www.who.int/publications/i/item/9789240046764
World Health Organization (WHO)

Mar 21st, 2022 - The Updated guidelines on Management of tuberculosis in children and adolescents include new recommendations that cover diagnostic approaches for TB, shorter treatment for children with non-severe drug-susceptible TB, a new option for the treatment of TB meningitis, the use of bedaquiline and delamanid in young children with multidrug- and rifampicin-resistant TB and decentralized and family-ce...

FDA Roundup: July 1, 2022 | FDA
https://www.fda.gov/news-events/press-announcements/fda-roundup-july-1-2022

Jul 1st, 2022 - For Immediate Release: July 01, 2022 Today, the U.S. Food and Drug Administration is providing an at-a-glance summary of news from around the agency: Today, the FDA announced a request for nominations for consumer representatives to serve on advisory committees and panels for which vacancies currently exist or are expected to occur in the near future. The FDA relies on our many advisory committ...

Exocrine Pancreatic Insufficiency: Risk Factors and Management Approaches
https://www.mdedge.com/gihepnews/article/255850/exocrine-pancreatic-insufficiency/exocrine-pancreatic-insufficiency-risk
Jodie Barkin, MD,, MDedge News

Jul 1st, 2022 - What characteristics or symptoms do you look for to identify patients who are at risk for exocrine pancreatic insufficiency (EPI)? Dr. Barkin: The first thing we have to understand is which patient populations we should consider.

ASCO outlines optimal treatments for patients with metastatic clear cell renal cell carcinoma
https://www.mdedge.com/hematology-oncology/article/255942/renal-cell-carcinoma/asco-outlines-optimal-treatments-patients
Jim Kling

Jun 30th, 2022 - For the first time, the American Society for Clinical Oncology (ASCO) has released guidelines for the treatment of metastatic clear cell renal cell carcinoma. This year in the U.

Coronavirus (COVID-19) Update: FDA Recommends Inclusion of Omicron BA.4/5 Component for COVID-19 Vaccine Booster Doses | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-recommends-inclusion-omicron-ba45-component-covid-19-vaccine-booster

Jun 30th, 2022 - For Immediate Release: June 30, 2022 Statement From: Peter Marks, M.D., PhD. Director - Center for Biologics Evaluation and Research (CBER) On Tuesday, the U.S. Food and Drug Administration’s independent experts on the Vaccines and Related Biological Products Advisory Committee met to publicly discuss whether a change to the current vaccine strain composition of COVID-19 vaccines for booster do...

Treatment of metabolic disorders using genomic technologies: Lessons from MMA.
https://doi.org/10.1002/jimd.12534
Journal of Inherited Metabolic Disease; Venturoni LE, Venditti CP

Jun 30th, 2022 - Hereditary methylmalonic acidemia (MMA) caused by deficiency of the enzyme methylmalonyl-CoA mutase (MMUT) is a relatively common and severe organic acidemia. The recalcitrant nature of the condition to conventional dietary and medical management has led to the use of elective liver and combined liver-kidney transplantation in some patients. However, liver transplantation is intrinsically limit...

Data-Driven Commentary on SARS-CoV-2 Infection, Vaccination, and Fertility.
https://doi.org/10.1093/aje/kwac073
American Journal of Epidemiology; Klipstein S, Dionne JA et. al.

Jun 30th, 2022 - A recent study by Wesselink et al. (Am J Epidemiol. 2022;191(XX):XXXX-XXXX) adds to the growing body of research finding that vaccination for coronavirus disease 2019 (COVID-19) is safe for individuals either seeking pregnancy or who are pregnant. The study's authors found no effect of COVID-19 vaccination on fecundity in a population of individuals with no known infertility who were attempting...

Heterogenous Disease Course and Long-term Outcome of Children's Interstitial Lung Disea...
https://doi.org/10.1513/AnnalsATS.202202-142OC
Annals of the American Thoracic Society; Carlens J, Johnson KT et. al.

Jun 30th, 2022 - Variable disease course and outcomes have been reported in Children's interstitial lung disease (ChILD) associated with Filamin A gene (FLNA) variants. To further delineate long term respiratory outcomes and identify potential contributing factors to severe disease course. We retrospectively collected longitudinal data from 3 centres on 9 cases (1 male) with FLNA variants and early respiratory ...

Less Than Subtotal Parathyroidectomy for Multiple Endocrine Neoplasia Type 1 Primary Hy...
https://doi.org/10.1007/s00268-022-06633-7 10.1111/j.1365-2265.2008.03324.x 10.1038/s41574-021-00468-3 10.1067/msy.1998.93107 10.1097/SLA.0b013e31815efda5 10.1111/j.1365-2265.2009.03672.x 10.1007/s12020-017-1377-3 10.1210/jc.2016-1477 10.1210/jc.2015-3909 10.1016/S0002-9440(10)64406-9 10.3389/fendo.2019.00123 10.1007/s00268-011-1068-9 10.1016/j.ijsu.2010.02.007 10.1001/jama.283.15.2008 10.1097/SLA.0b013e31824c5145 10.1007/s00268-016-3624-9 10.1038/s41598-020-67424-5 10.1186/1750-1172-8-50 10.1111/j.1365-2265.2006.02438.x 10.1007/s00268-017-4366-z 10.1067/msy.2002.128607 10.1530/EC-19-0321 10.1007/s00104-004-0838-4 10.1007/BF01655552 10.1111/cen.14112 10.1001/archsurg.141.3.235 10.1002/bjs.7154 10.1001/archsurg.140.4.374 10.1007/s00268-015-3297-9 10.1080/110241501750099294 10.1016/j.surg.2013.03.004 10.1016/j.ciresp.2018.06.014 10.1245/ASO.2006.12.009 10.1016/s0039-6060(03)00406-9 10.1016/j.surg.2014.08.006 10.1001/jamasurg.2016.2310 10.1530/EJE-18-0580 10.1210/jc.2012-1808 10.1002/jbmr.1979 10.4158/EP13328.OR 10.1002/jbmr.2273 10.1016/j.jamcollsurg.2014.07.412 10.1007/s00268-012-1451-1 10.1007/s00259-018-4123-z 10.1007/s00268-020-05695-9 10.2967/jnumed.119.225771 10.1002/lary.28566 10.1007/s10897-006-9047-2 10.1016/j.surg.2020.08.021 10.3389/fendo.2018.00558 10.1016/S0039-6060(98)70040-6
World Journal of Surgery; Bouriez D, Gronnier C et. al.

Jun 30th, 2022 - Multiple endocrine neoplasia type 1 (MEN1)-associated primary hyperparathyroidism (pHPT) is classically associated with an asymmetric and asynchronous parathyroid involvement. Subtotal parathyroidectomy (STP), which is currently the recommended surgical treatment, carries a high risk of permanent hypoparathyroidism. The results of less than subtotal parathyroidectomy (LSTP) are conflicting, and...

Management of Locally Recurrent Retroperitoneal Sarcoma in the Adult: An Updated Consen...
https://doi.org/10.1245/s10434-022-11864-y 10.1002/cncr.21761 10.1097/CCO.0000000000000377 10.1016/j.suronc.2018.11.004 10.1245/s10434-020-09065-6 10.1177/0003134820964460 10.1016/j.suronc.2019.03.002 10.1002/jso.24888 10.1097/00000658-199809000-00008 10.1002/cncr.20269 10.1093/annonc/mdp298 10.1002/jso.23463 10.1002/jso.25606 10.1097/SLA.0000000000001149 10.1245/s10434-016-5538-z 10.1097/CCO.0000000000000746 10.1245/s10434-021-09654-z 10.1016/j.ejca.2019.11.013 10.1086/656735 10.1002/cncr.31699 10.1155/2018/3056562 10.1245/s10434-019-07421-9 10.1002/jso.25863 10.1016/j.jamcollsurg.2019.09.013 10.1245/s10434-012-2342-2 10.1080/14737140.2019.1625774 10.1097/SLA.0000000000001447 10.1245/s10434-014-3643-4 10.1245/s10434-021-10472-6 10.1111/1754-9485.12123 10.1038/s41598-019-43215-5 10.1155/2021/7191363 10.1002/jso.26379 10.1155/2020/8363986 10.1002/jso.24875 10.1002/jso.23949 10.1245/s10434-020-09290-z 10.1016/j.ejso.2018.07.001 10.1245/s10434-019-08121-0 10.1002/jso.23783 10.1158/1078-0432.CCR-18-2700 10.1002/cncr.33139 10.1016/j.ejso.2020.08.030 10.1016/j.ejca.2021.08.008 10.1245/s10434-016-5523-6 10.1002/jso.25337 10.1245/s10434-021-10024-y 10.1097/SLA.0b013e3181928f2f 10.1016/j.jamcollsurg.2013.10.009 10.1002/jso.25082 10.1002/jso.24929 10.1002/jso.25291 10.1245/s10434-018-6417-6 10.1245/s10434-018-6472-z 10.1007/s10147-018-01383-w 10.1097/sla.0b013e3181b2468b 10.1002/jso.24745 10.1016/S1470-2045(20)30446-0 10.1002/cncr.33323 10.1245/s10434-020-09445-y 10.1245/s10434-017-6137-3 10.1016/s0360-3016(00)01589-3 10.1186/1471-2407-14-617 10.1016/j.jss.2011.02.004 10.1016/j.radonc.2013.10.041 10.1016/j.ejso.2018.02.001 10.1016/j.ejso.2005.04.010 10.1245/s10434-007-9463-z 10.1158/0008-5472.CAN-19-0203 10.1016/j.canlet.2020.04.026 10.1177/1073274820983028 10.18632/oncotarget.9476 10.2217/fon-2021-0284 10.1136/bmjopen-2019-035546 10.1016/S1072-7515(01)01024-9 10.1097/CCO.0000000000000535
Annals of Surgical Oncology; Tseng WW, Swallow CJ et. al.

Jun 30th, 2022 - Surgery is the mainstay of treatment for retroperitoneal sarcoma (RPS), but local recurrence is common. Biologic behavior and recurrence patterns differ significantly among histologic types of RPS, with implications for management. The Transatlantic Australasian RPS Working Group (TARPSWG) published a consensus approach to primary RPS, and to complement this, one for recurrent RPS in 2016. Sinc...

Antitumour effects of apatinib in progressive, metastatic differentiated thyroid cancer...
https://doi.org/10.1007/s12020-022-03113-9 10.1001/jama.2017.2719 10.1089/thy.2011.0535 10.1210/jc.2005-2838 10.1016/S0140-6736(14)60421-9 10.1056/NEJMoa1406470 10.1111/j.1349-7006.2011.01939.x 10.1210/clinem/dgab196 10.1016/j.ejca.2008.10.026 10.1007/s40265-018-0903-9 10.1002/cncy.22136 10.1007/s12022-022-09707-3 10.20945/2359-3997000000046 10.1089/thy.2018.0626 10.1210/jc.2005-1534 10.1089/10507250152741028 10.1016/j.calet.2015.01.024
Endocrine Shi L, You Q et. al.

Jun 30th, 2022 - Management of progressive, metastatic radioactive iodine refractory differentiated thyroid cancer (RAIR-DTC) has been a great challenge due to its poor prognosis and limited treatment options. Recently, apatinib, an orally anti-angiogenic tyrosine kinase inhibitor (TKI) is reported to be useful for treatment of progressive RAIR-DIC. The aim of this study was to evaluate the antitumour effect of...

Endocrine manifestations of paediatric intracranial germ cell tumours: from diagnosis t...
https://doi.org/10.1007/s12020-022-03121-9 10.1159/000496564
Endocrine Partenope C, Pozzobon G et. al.

Jun 30th, 2022 - We examined endocrine manifestations in a cohort of paediatric patients with IC-GCTs at diagnosis and during follow-up, integrating clinical, radiological, histopathological and laboratory data. Diabetes insipidus (DI), growth hormone deficiency (GHD), hypothyroidism, adrenal insufficiency, precocious puberty (PP)/hypogonadism were diagnosed clinically and biochemically. The prevalence of endoc...

Rationale and Design of the Cardiac CARE Trial: A Randomized Trial of Troponin-Guided N...
https://doi.org/10.1161/CIRCHEARTFAILURE.121.009445
Circulation. Heart Failure; Henriksen PA, Hall P et. al.

Jun 30th, 2022 - Anthracyclines are effective cytotoxic drugs used in the treatment of breast cancer and lymphoma but are associated with myocardial injury, left ventricular dysfunction, and heart failure. Anthracycline-induced cardiotoxicity is highly variable in severity and without a proven therapeutic intervention. β-Adrenergic receptor blockers and renin-angiotensin-system inhibitor therapies have been ass...

Chimeric antigen receptor T-cell therapy is superior to standard of care as second-line...
https://doi.org/10.1111/bjh.18335
British Journal of Haematology; Shargian L, Raanani P et. al.

Jun 30th, 2022 - Treatment with high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is considered standard of care (SOC) second-line treatment for relapsed or refractory large B-cell lymphoma (LBCL). However, outcomes remain suboptimal. A systematic review and meta-analysis of randomised controlled trials comparing efficacy and safety of SOC versus chimeric antigen receptor T-cell (CA...