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About 416,588 results

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Phase 2 Trial of Rituximab in Acetylcholine Receptor Antibody-Positive Generalized Myas...
https://doi.org/10.1212/WNL.0000000000013121
Neurology Nowak RJ, Coffey CS et. al.

Dec 4th, 2021 - To determine whether rituximab is safe and potentially beneficial, warranting further investigation in an efficacy trial for acetylcholine receptor antibody-positive generalized MG (AChR-Ab+ gMG). The B-Cell Targeted Treatment in MG (BeatMG) study was a randomized, double-blind, placebo-controlled, multicenter phase-2 trial that utilized a futility design. Individuals 21-90 years of age, with A...

Technical validation of real-world monitoring of gait: a multicentric observational study.
https://doi.org/10.1136/bmjopen-2021-050785
BMJ Open; Mazzà C, Alcock L et. al.

Dec 4th, 2021 - Existing mobility endpoints based on functional performance, physical assessments and patient self-reporting are often affected by lack of sensitivity, limiting their utility in clinical practice. Wearable devices including inertial measurement units (IMUs) can overcome these limitations by quantifying digital mobility outcomes (DMOs) both during supervised structured assessments and in real-wo...

Cell free HPV DNA provides an accurate and rapid diagnosis of HPV-associated head and n...
https://doi.org/10.1158/1078-0432.CCR-21-3151
Clinical Cancer Research : an Official Journal of the Ame... Siravegna G, O'Boyle CJ et. al.

Dec 4th, 2021 - HPV-associated Head and Neck Squamous Cell Carcinoma(HPV+HNSCC) is the most common HPV-associated malignancy in the United States and continues to increase in incidence. Current diagnostic approaches for HPV+HNSCC rely on tissue biopsy followed by histomorphologic assessment and detection of HPV indirectly by p16 immunohistochemistry. Such approaches are invasive and have variable sensitivity. ...

Head-to-head comparison of 68Ga-FAPI-46 and 18F-FDG PET/CT for evaluation of head and n...
https://doi.org/10.2967/jnumed.121.262831
Journal of Nuclear Medicine : Official Publication, Socie... Promteangtrong C, Siripongsatian D et. al.

Dec 4th, 2021 - 68Ga-conjugated fibroblast activation protein inhibitor (68Ga-FAPI) has become an attractive agent for positron emission tomography (PET). This study aimed to compare 68Ga-FAPI-46 PET/computed tomography (CT) with 18F-fluorodeoxy-D-glucose (18F-FDG) PET/CT for detecting primary cancer and metastatic lesions in patients with head and neck squamous cell carcinoma (HNSCC). Methods: Twelve patients...

Prognostic value of Urokinase-type Plasminogen Activator Receptor (uPAR)-PET/CT in Head...
https://doi.org/10.2967/jnumed.121.262866
Journal of Nuclear Medicine : Official Publication, Socie... Risoer LM, Clausen MM et. al.

Dec 4th, 2021 - Purpose: The aim of this phase II trial (NCT02965001) was to evaluate the prognostic value of urokinase-type plasminogen activator receptor (uPAR)-PET/CT with the novel ligand 68Ga-NOTA-AE105 in head and neck cancer and compare it to 18F-fluorodeoxyglucose (18F-FDG). Materials and Methods: Patients with head and neck squamous cell carcinoma (HNSCC) referred to curatively intended radiotherapy w...

Diagnostic performances of cervical ultrasound, sestamibi scintigraphy and contrast-enh...
https://doi.org/10.2967/jnumed.121.261900
Journal of Nuclear Medicine : Official Publication, Socie... Boudousq V, Guignard N et. al.

Dec 4th, 2021 - Purpose: Preoperative localization of pathological parathyroids is crucial for a minimally invasive treatment of primary hyperparathyroidism (PHPT). This study compares contrast-enhanced 18F-fluorocholine positron emission tomography (FCH-PET/CT), cervical ultrasound (CU) and conventional scintigraphic imaging modalities (MIBI scintigraphy), combined and individually for preoperative localizati...

Primary plasma cell leukemia: consensus definition by the International Myeloma Working...
https://doi.org/10.1038/s41408-021-00587-0 10.1016/0002-9343(87)90942-9 10.1001/archinte.133.5.813 10.1111/bjh.15092 10.1182/blood-2014-03-565051 10.1182/blood.V93.3.1032 10.1111/j.1365-2141.1994.tb05114.x 10.1016/S0889-8588(05)70125-8 10.1038/leu.2012.336 10.1002/cncr.31718 10.1038/leu.2008.4 10.1038/s41408-018-0153-9 10.1182/blood.V88.1.289.289 10.1038/leu.2016.205 10.1007/s00277-014-2211-0 10.3324/haematol.2016.158303 10.1038/s41408-018-0140-1 10.1182/blood-2020-141525 10.1038/leu.2012.107 10.1158/1078-0432.CCR-12-2043 10.1016/j.leukres.2018.09.007 10.1182/blood-2012-05-408682 10.1038/leu.2011.312 10.1002/ajh.23600 10.1093/annonc/mdr480 10.1038/leu.2013.241 10.1200/JCO.2015.63.1929 10.3324/haematol.2009.013334 10.1038/leu.2014.98 10.1182/blood-2005-05-1858 10.1111/bjh.13484 10.1038/s41408-018-0153-9 10.1080/10428190601016159 10.1080/1042819021000029713
Blood Cancer Journal; Fernández de Larrea C, Kyle R et. al.

Dec 4th, 2021 - Primary plasma cell leukemia (PCL) has a consistently ominous prognosis, even after progress in the last decades. PCL deserves a prompt identification to start the most effective treatment for this ultra-high-risk disease. The aim of this position paper is to revisit the diagnosis of PCL according to the presence of circulating plasma cells in patients otherwise meeting diagnostic criteria of m...

Isocitrate dehydrogenase mutations are associated with altered IL-1β responses in acute...
https://doi.org/10.1038/s41375-021-01487-9
Leukemia Sunthankar KI, Jenkins MT et. al.

Dec 4th, 2021 - Mutations in isocitrate dehydrogenase 2 (IDH2) have been noted to impact cellular differentiation in addition to DNA and histone methylation. However, little is known about the impact of IDH2 mutations on intracellular signaling. Using an isogenic cell line model, we investigated both differentiation and signaling responses in IDH2 mutant cells and show augmented responses to inflammatory immun...

Liver Transplantation for intrahepatic cholangiocarcinoma: ready for prime time?
https://doi.org/10.1002/hep.32258
Hepatology (Baltimore, Md.); Sapisochin G, Ivanics T et. al.

Dec 4th, 2021 - Cholangiocarcinoma (CCA) represents the second most common primary liver malignancy after hepatocellular carcinoma and has risen in incidence globally in the past decades. Intrahepatic cholangiocarcinoma (iCCA) comprises 20% of all CCAs, with the rest being extrahepatic (including perihilar [pCCA] and distal CCA). Though long representing an absolute contraindication for liver transplantation (...

Novel role for tumor suppressor gene, liver kinase B1, in epithelial mesenchymal transi...
https://doi.org/10.1111/ajt.16903
American Journal of Transplantation : Official Journal Of... Rahman M, Ravichandran R et. al.

Dec 4th, 2021 - Epithelial mesenchymal transition (EMT) has been implicated to play a role in chronic lung allograft dysfunction (CLAD). Liver kinase B1 (LKB1), a tumor suppressor gene, can regulate EMT. However, its role in CLAD development following lung transplantation remains unknown. Using qRT-PCR, biopsies from lung transplant recipients with bronchiolitis obliterans syndrome (BOS) demonstrated significa...

Efficiency of high cumulative cisplatin dose in high- and low-risk patients with locore...
https://doi.org/10.1002/cam4.4477
Cancer Medicine; Jiang YT, Chen KH et. al.

Dec 4th, 2021 - The optimal cumulative cisplatin dose (CCD) during radiation therapy for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients receiving induction chemotherapy (IC) plus CCRT remains controversial. This study aimed to explore the treatment efficiency of CCD for high-and low-risk patients with LA-NPC. Data from 472 LA-NPC patients diagnosed from 2014 to 2018 and treated with IC plus...

Fully covered metal stents versus plastic stents for preoperative biliary drainage in p...
https://doi.org/10.1002/jhbp.1090
Journal of Hepato-biliary-pancreatic Sciences; Mandai K, Tsuchiya T et. al.

Dec 4th, 2021 - /Purpose Whether a fully covered self-expanding metal stent (FCSEMS) or plastic stent (PS) is preferable for preoperative biliary drainage in patients with resectable pancreatic cancer (RPC) is controversial. This study aimed to evaluate the safety and efficacy of drainage with FCSEMS for obstructive jaundice caused by RPC without neoadjuvant chemotherapy. Seventy patients with RPC who required...

Prognostic significance of ethnicity and age in advanced stage epithelial ovarian cance...
https://doi.org/10.1016/j.ygyno.2021.11.013
Gynecologic Oncology; duPont NC, Enserro D et. al.

Dec 4th, 2021 - Age and ethnicity are among several factors that influence overall survival (OS) in ovarian cancer. The study objective was to determine whether ethnicity and age were of prognostic significance in women enrolled in a clinical trial evaluating the addition of bevacizumab to front-line therapy. Women with advanced stage ovarian, primary peritoneal, or fallopian tube cancer were enrolled in a pha...

Association of site of treatment with clinical outcomes following intravenous antimicro...
https://doi.org/10.1016/j.jcf.2021.11.009
Journal of Cystic Fibrosis : Official Journal of the Euro... Sanders DB, Khan U et. al.

Dec 4th, 2021 - In the STOP2 (Standardized Treatment of Pulmonary Exacerbations-2) study, intravenous (IV) antimicrobial treatment duration for adults with cystic fibrosis (CF) experiencing pulmonary exacerbations (PEx) was determined based on initial treatment response. The impact of home vs hospital care remains an important clinical question in CF. Our hypothesis was that STOP2 participants treated at home ...

SARS-CoV-2 transmission in schools in Korea: nationwide cohort study.
https://doi.org/10.1136/archdischild-2021-322355
Archives of Disease in Childhood; Choe YJ, Park YJ et. al.

Dec 4th, 2021 - There is an urgent public need to readdress the school closure strategies. We aimed to describe the epidemiology of COVID-19 in schools and school-aged children to understand their roles in transmitting SARS-CoV-2 in Korea. Retrospective cohort study. All schools in Korea PATIENTS: All school-aged children in Korea. None (observational study). Incidence rate, proportion of affected schools. Bet...

Spectrum of SARS-CoV-2-Related Clinical Syndromes in Children: A Year in the Life.
https://doi.org/10.1177/00099228211064655
Clinical Pediatrics; Khan M, Dang L et. al.

Dec 4th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a wide pediatric clinical spectrum. Initial reports suggested that children had milder symptoms compared with adults; then diagnosis of multisystem inflammatory syndrome in children (MIS-C) emerged. We performed a retrospective cohort study of hospitalized patients at a children's hospital over 1 year. Our objectives were to study...

Outcomes of surgical bleb revision at a tertiary Singapore eye hospital.
https://doi.org/10.1007/s10792-021-02061-z 10.3109/08820538.2013.771199 10.1016/j.ajo.2011.10.024 10.1016/S0161-6420(99)00174-8 10.1016/j.ajo.2014.05.021 10.1016/S0161-6420(01)00838-7 10.1097/IJG.0b013e3181e87efc 10.1097/00061198-200208000-00005 10.1016/S0161-6420(00)00282-7 10.1016/S0002-9394(00)00653-X 10.1136/bjo.88.1.99 10.1097/IJG.0b013e31821e83e6 10.1136/bjo.86.2.238 10.1016/S0161-6420(02)01069-2 10.1111/j.1442-9071.1998.tb01331.x 10.1038/sj.eye.6701477 10.1097/IJG.0000000000000322 10.1097/00061198-200406000-00015
International Ophthalmology; Chew ACY, Htoon HM et. al.

Dec 4th, 2021 - To describe the outcomes of surgical bleb revisions from a tertiary glaucoma service in Singapore. One hundred and thirty-one eyes of 129 patients who underwent surgical bleb revisions at the Singapore National Eye Centre between 2007 and 2014 were included in the study. The indications for bleb revision were: bleb-related infection (BRI), early and late bleb leak, early and late overfiltration...

Examination of the association of muscle dysmorphia (bigorexia) and social physique anx...
https://doi.org/10.1111/ppc.12980
Perspectives in Psychiatric Care; Duran S, Öz YC

Dec 4th, 2021 - This study aimed to examine the association between social physique anxiety and muscular dystrophy in bodybuilders. This cross-sectional study included 384 male bodybuilders. 5.7% of the participants reported muscular dystrophy. Younger age and use of protein powder were associated with higher scores on the muscle dysmorphic disorder Inventory. Higher muscular dystrophy was associated with high...

Factors associated with postoperative complications and costs for adrenalectomy in beni...
https://doi.org/10.1016/j.surg.2021.10.065
Surgery Sung TY, Tennakoon L et. al.

Dec 4th, 2021 - The incidence of adrenal incidentaloma has been increasing, and indications of and approaches to adrenalectomy are diverse. Drivers of complications and costs are not well identified. The 2016 National Inpatient Sample data were used to identify patients who underwent adrenalectomy for benign adrenal disorders, such as Cushing syndrome, primary hyperaldosteronism, pheochromocytoma, and other be...