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About 419,145 results

IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875405
BMC Cancer; Cai W, Ma Y et. al.

Jan 27th, 2023 - Insulin-like growth factor-1 receptor (IGF-1R) promotes cell proliferation and migration and inhibitsapoptosis, all of which can contribute to the development of cancers. This study investigated the effect and mechanism of IGF-1R in mediating the desensitization of hepatocellular carcinoma (HCC) to sorafenib. IGF-1R, highly expressed in the HCC cell lines SK-Hep1 and HepG2, promotes cell prolif...

TRPA1 as a potential factor and drug target in scleroderma: dermal fibrosis and alterna...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875496
Arthritis Research & Therapy; Mäki-Opas I, Hämäläinen M et. al.

Jan 27th, 2023 - Systemic sclerosis is a rheumatoid disease best known for its fibrotic skin manifestations called scleroderma. Alternatively activated (M2-type) macrophages are normally involved in the resolution of inflammation and wound healing but also in fibrosing diseases such as scleroderma. TRPA1 is a non-selective cation channel, activation of which causes pain and neurogenic inflammation. In the prese...

FT-GPI, a highly sensitive and accurate predictor of GPI-anchored proteins, reveals the...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876418
Malaria Journal; Sauer LM, Canovas R et. al.

Jan 27th, 2023 - Protozoan parasites are known to attach specific and diverse group of proteins to their plasma membrane via a GPI anchor. In malaria parasites, GPI-anchored proteins (GPI-APs) have been shown to play an important role in host-pathogen interactions and a key function in host cell invasion and immune evasion. Because of their immunogenic properties, some of these proteins have been considered as ...

HBx-induced PLA2R overexpression mediates podocyte pyroptosis through the ROS-NLRP3 sig...
https://doi.org/10.1080/0886022X.2023.2170808
Renal Failure; Feng M, Yu Y et. al.

Jan 27th, 2023 - Hepatitis B virus-associated glomerulonephritis (HBV-GN) is one of the main types of secondary glomerular diseases, and podocyte injury is an important pathogenic mechanism of HBV-GN, participating in the occurrence and development of HBV-GN. However, the specific mechanism of podocyte injury remains to be studied. Human renal podocytes cultured in vitro were divided into six groups. The podocy...

Myeloid/lymphoid neoplasm with eosinophilia and BCR/FGFR1 rearrangement with transforma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878768
Journal of Medical Case Reports; Isaza AP, Quintero SC et. al.

Jan 27th, 2023 - Myeloproliferative neoplasms are a group of diseases with diverse biological and clinical characteristics. As a provisional separate entity, myeloid/lymphoid neoplasms with eosinophilia and genetic rearrangement have been described, which may present an initial clinical behavior of myeloproliferation and be characterized by varied genetic rearrangements. One of these entities is associated with...

A patient with X-linked retinoschisis and exudative retinal detachment associated with ...
https://doi.org/10.1080/13816810.2022.2154809
Ophthalmic Genetics; Tondelli NN, Mencaroni BM et. al.

Jan 26th, 2023 - X-linked retinoschisis (XLRS) is a rare retinal dystrophy due to pathogenic variants in the RS1 gene. The hallmark of the disease is a foveal spoke-wheel appearance. The purpose of this report is to expand the phenotypic spectrum of XLRS reporting a patient with atypical phenotype of XLRS associated with Coats-like phenotype. This is a case report of a patient diagnosed with XLRS who underwent ...

Successful lung transplantation using an allograft from a COVID-19-recovered donor: a p...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833374
American Journal of Transplantation : Official Journal Of... Saharia KK, Ramelli SC et. al.

Jan 26th, 2023 - Although the risk of SARS-CoV-2 transmission through lung transplantation from acutely infected donors is high, the risks of virus transmission and long-term lung allograft outcomes are not as well described when using pulmonary organs from COVID-19-recovered donors. We describe successful lung transplantation for a COVID-19-related lung injury using lungs from a COVID-19-recovered donor who wa...

Identification of mosquito proteins that differentially interact with alphavirus nonstr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876241
PLoS Neglected Tropical Diseases; Byers NM, Burns PL et. al.

Jan 26th, 2023 - Chikungunya virus (CHIKV) and the closely related onyong-nyong virus (ONNV) are arthritogenic arboviruses that have caused significant, often debilitating, disease in millions of people. However, despite their kinship, they are vectored by different mosquito subfamilies that diverged 180 million years ago (anopheline versus culicine subfamilies). Previous work indicated that the nonstructural p...

Analysis of regulatory sequences in exosomal DNA of NANOGP8.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876286
PloS One; Vaidya M, Smith J et. al.

Jan 26th, 2023 - Exosomes participate in intercellular communication by transporting functionally active molecules. Such cargo from the original cells comprising proteins, micro-RNA, mRNA, single-stranded (ssDNA) and double-stranded DNA (dsDNA) molecules pleiotropically transforms the target cells. Although cancer cells secrete exosomes carrying a significant level of DNA capable of modulating oncogene expressi...

Mainstreaming of genomics in oncology: a nationwide survey of the genomics training nee...
https://doi.org/10.7861/clinmed.2022-0372
Clinical Medicine (London, England); Tutika RK, Bennett JA et. al.

Jan 26th, 2023 - Genomics is rapidly changing treatment paradigms for cancers, obligating oncologists to have good genomics knowledge. Through this survey, we aimed to assess the current understanding of cancer genomics among UK oncologists. We conducted a web-based nation-wide self-assessment survey of the cancer genomics knowledge of UK clinical and medical oncology trainees and consultants. In total, 150 onc...

Real-World Data on Olaparib in Relapsed BRCA-mutated Ovarian Cancer: A Multicenter GINE...
https://doi.org/10.21873/anticanres.16202
Anticancer Research; Bourien H, Lefevre LB et. al.

Jan 26th, 2023 - Olaparib was approved in 2014 by the European Medicines Agency (EMA) as maintenance treatment for patients with breast cancer gene (BRCA)-mutated platinum-sensitive relapsed high-grade epithelial ovarian cancer (EOC) following the results of the Study 19. We present the results of a national real-world study on the effectiveness of olaparib in relapsed BRCA-mutated EOC patients. Patients with E...

Clear-cell Variant of Mucoepidermoid Carcinoma Presenting as a Palatal Mass in a 10-Yea...
https://doi.org/10.21873/anticanres.16238
Anticancer Research; Han SH, O'Toole TR et. al.

Jan 26th, 2023 - The clear-cell variant of mucoepidermoid carcinoma (MEC) involving minor salivary glands is extremely rare in children. We report a case of clear-cell variant MEC in the minor salivary gland in a 10-year-old boy who presented with a mass of the right hard palate. Fine-needle aspiration showed features suggestive of clear-cell variant of MEC. Microscopically, the tumor cells showed predominant c...

Treatment of Human Pancreatic Cancers Following Local and Systemic Administration of On...
https://doi.org/10.21873/anticanres.16190
Anticancer Research; Ono R, Takayama K et. al.

Jan 26th, 2023 - Oncolytic adenoviruses (Ads) (OAds) are gaining attention as an effective remedy for pancreatic cancer. Most OAds are based on human Ad serotype 5 (Ad5) (OAd5); however, two major drawbacks of OAd5 have been reported. Expression of coxsackievirus-adenovirus receptor, a primary infection receptor of Ad5, is often decreased on malignant tumor cells, including pancreatic cancers. More than 60% of ...

Epithelial-Mesenchymal Transition Phenotype and Peritumoral Immune Cell Infiltration in...
https://doi.org/10.21873/anticanres.16201
Anticancer Research; Oh CR, Kim HD et. al.

Jan 26th, 2023 - This study evaluated the clinical implications of epithelial-mesenchymal transition (EMT) markers and peritumoral immune cell infiltration in patients with biliary tract cancer (BTC) treated with gemcitabine plus cisplatin (GemCis). Forty-five patients with advanced BTC who received GemCis were included as the study population. We conducted multiplex immunohistochemistry and examined EMT marker...

PCDH17 gene promoter methylation status in a cohort of Egyptian women with epithelial o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878799
BMC Cancer; Elsharkawi SM, Elkaffash D et. al.

Jan 26th, 2023 - Ovarian cancer is a leading cause of female mortality. Epigenetic changes occur in early stages of carcinogenesis and represent a marker for cancer diagnosis. Protocadherin 17 (PCDH17) is a tumor suppressor gene involved in cell adhesion and apoptosis. The methylation of PCDH17 gene promoter has been described in several cancers including ovarian cancer. The aim of the study was to compare the ...

A multi-omic analysis reveals the esophageal dysbiosis as the predominant trait of eosi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875471
Journal of Translational Medicine; Massimino L, Barchi A et. al.

Jan 26th, 2023 - Eosinophilic esophagitis (EoE) is a chronic immune-mediated rare disease, characterized by esophageal dysfunctions. It is likely to be primarily activated by food antigens and is classified as a chronic disease for most patients. Therefore, a deeper understanding of the pathogenetic mechanisms underlying EoE is needed to implement and improve therapeutic lines of intervention and ameliorate ove...

SARS-CoV-2 variants-associated outbreaks of COVID-19 in a tertiary institution, North-C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876355
PloS One; Adeyemi OO, Ndodo ND et. al.

Jan 26th, 2023 - The COVID-19 global pandemic is being driven by evolving SARS-CoV-2 variants with consequential implications on virus transmissibility, host immunity, and disease severity. Continuous molecular and genomic surveillance of the SARS-CoV-2 variants is therefore necessary for public health interventions toward the management of the pandemic. This study is a retrospective analysis of COVID-19 cases ...

Phylogenetic analysis of the MCL1 BH3 binding groove and rBH3 sequence motifs in the p5...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876281
PloS One; McGriff A, Placzek WJ

Jan 26th, 2023 - B-cell lymphoma 2 (Bcl-2) proteins are central, conserved regulators of apoptosis. Bcl-2 family function is regulated by binding interactions between the Bcl-2 homology 3 (BH3) motif in pro-apoptotic family members and the BH3 binding groove found in both the pro-apoptotic effector and anti-apoptotic Bcl-2 family members. A novel motif, the reverse BH3 (rBH3), has been shown to interact with th...

Diagnostic accuracy of the Panbio COVID-19 antigen rapid test device for SARS-CoV-2 det...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876661
PloS One; Irungu JK, Munyua P et. al.

Jan 26th, 2023 - Accurate and timely diagnosis is essential in limiting the spread of SARS-CoV-2 infection. The reference standard, rRT-PCR, requires specialized laboratories, costly reagents, and a long turnaround time. Antigen RDTs provide a feasible alternative to rRT-PCR since they are quick, relatively inexpensive, and do not require a laboratory. The WHO requires that Ag RDTs have a sensitivity ≥80% and s...

FUT8-AS1/miR-944/Fused in Sarcoma/Transcription Factor 4 Feedback Loop Participates in ...
https://doi.org/10.1016/j.ajpath.2022.10.010
The American Journal of Pathology; Geng Z, Huang Y et. al.

Jan 26th, 2023 - As a common type of head and neck squamous cell carcinoma, oral squamous cell carcinoma (OSCC) is a lethal and deforming disease. Long noncoding RNAs have emerged as critical modulators in different malignancies. However, the role of fucosyltransferase 8 antisense RNA 1 (FUT8-AS1) in OSCC still remains elusive. In this study, quantitative RT-PCR and Western blot were used for the measurement of...