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About 384,840 results

IGF2BP3‑stabilized SIX4 promotes the proliferation, migration, invasion and tube format...
https://doi.org/10.3892/mmr.2022.12748
Molecular Medicine Reports; Han J, Hu X

May 27th, 2022 - The mortality rate of ovarian cancer (OC) is the highest among the different types of female reproductive system cancers. SIX homeobox 4 (SIX4), a member of the homeobox family, subfamily SIX, fulfills an important role in metastasis and angiogenesis in a variety of types of cancer. The aim of the present study was to investigate both the effects and the underlying mechanism of SIX4 on angiogen...

MicroRNA‑141 inhibits the differentiation of bone marrow‑derived mesenchymal stem cells...
https://doi.org/10.3892/mmr.2022.12750
Molecular Medicine Reports; Xue F, Wu J et. al.

May 27th, 2022 - Osteonecrosis of the femoral head (ONFH) affects the life of patients. MicroRNA‑141 (miR‑141) has been found associated with proliferation of bone marrow‑derived mesenchymal stem cells (BMSCs). E2F transcription factor 3 (E2F3) has been identified as the target of miR‑141 to regulate cell proliferation. The aim of the present study was to investigate whether miR‑141 and E2F3 were involved in th...

Receptor for activated C kinase 1 promotes cervical cancer lymph node metastasis via th...
https://doi.org/10.3892/ijo.2022.5373
International Journal of Oncology; Xu L, Li J et. al.

May 27th, 2022 - Cervical cancer (CC), an aggressive form of squamous cell carcinoma, is characterized by early‑stage lymph node metastasis and an extremely poor prognosis. The authors have previously demonstrated that patients with CC have aberrant glycolysis. The upregulation of receptor for activated C kinase 1 (RACK1) is associated with CC lymph node metastasis (LNM). However, its role in mediating aerobic ...

ncRNA-Mediated High Expression of LPCAT1 Correlates with Poor Prognosis and Tumor Immun...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126685
Journal of Immunology Research; Sun Q, Liu X et. al.

May 27th, 2022 - To investigate the expression of LPCAT1 in liver hepatocellular carcinoma (LIHC) and its relationship with prognosis and immune infiltration and predict its upstream nonencoding RNAs (ncRNAs). In this study, expression analysis and survival analysis for LPCAT1 in pan cancers were first performed by using The Cancer Genome Atlas (TCGA) data, which suggested that LPCAT1 might be a potential LIHC ...

More Than 200 Monkeypox Cases Confirmed in 21 Countries
https://www.medscape.com/viewarticle/974681

May 26th, 2022 - The global tally of monkeypox cases has surpassed 200 and continues to increase daily, reaching across 21 countries, according to the latest report from the European Centre for Disease Prevention and Control. On Wednesday, the agency reported 219 confirmed cases worldwide, including 9 in the U.S. and 71 in the U.K. Later that day, the U.K. reported 7 more cases, bringing the global total to 226...

"PFH/AGM-CBA/HSV-TK/LIPOSOME-Affibody": Novel Targeted Nano Ultrasound Contrast Agents ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124479
Drug Design, Development and Therapy; Zhou H, Liu H et. al.

May 26th, 2022 - Gastric cancer is one of the most lethal malignancies in the world. However, the current research on the diagnosis and treatment of nano-ultrasound contrast agents in the field of tumor is mostly focused on breast cancer, ovarian cancer, prostate cancer, liver cancer, etc. Due to the interference of gas in the stomach, there is no report on the treatment of gastric cancer. Herpes simplex virus ...

Identification of an endoplasmic reticulum stress-related signature associated with cli...
https://doi.org/10.1186/s12883-022-02709-y 10.3109/08977194.2014.985787 10.1038/nrdp.2015.17 10.1038/srep34922 10.1084/jem.20130678 10.1158/1078-0432.CCR-06-2070 10.1016/j.ymthe.2016.10.003 10.2147/OTT.S194770 10.1038/s41568-020-00312-2 10.2174/138161211795049660 10.1016/j.brainres.2016.03.015 10.3389/fonc.2020.608911 10.1016/j.phrs.2020.104823 10.1038/nature17041 10.1215/15228517-2008-006 10.1038/onc.2012.174 10.1158/0008-5472.CAN-07-0625 10.1111/j.1476-5381.2009.00345.x 10.18632/oncotarget.17737 10.1038/sj.cdd.4401359 10.1179/1743132814Y.0000000423 10.1038/sj.cdd.4402269 10.1038/nrc3380 10.1007/s00401-015-1405-4 10.1038/nrclinonc.2016.204 10.1093/nar/gkaa970 10.1089/omi.2011.0118 10.1038/nature08460 10.1186/1471-2105-14-7 10.1038/nri.2017.49 10.1371/journal.pone.0001195 10.1371/journal.pone.0107468 10.1007/s10555-012-9415-3 10.3389/fcell.2020.00642 10.1007/s10571-020-00857-8 10.18632/aging.101625 10.1083/jcb.201006121 10.2144/000114029 10.1158/0008-5472.CAN-07-2047 10.1096/fasebj.2.10.3290025 10.1158/1078-0432.CCR-04-2159 10.1007/s13277-013-1373-z 10.1128/MCB.01453-06 10.1016/j.cellsig.2013.11.008 10.1038/emboj.2008.225 10.1016/j.ejca.2013.02.021 10.3389/fonc.2020.571189 10.3389/fcell.2021.694633 10.3389/fonc.2020.590861 10.18632/aging.202886 10.1038/nmeth.2956 10.3892/ol.2018.8998 10.1007/s00330-018-5723-5 10.1038/s41388-019-0878-3 10.1038/sj.onc.1208615 10.2174/156800909788166637 10.18632/oncotarget.16710 10.1097/CCO.0b013e32833dead8 10.1158/1078-0432.CCR-09-1322 10.1016/j.ejphar.2009.06.064 10.1038/nrd2755 10.1146/annurev.biochem.73.011303.074134 10.1016/j.canlet.2014.12.028 10.1016/j.mam.2017.12.003 10.1158/1078-0432.CCR-16-2598 10.3389/fimmu.2019.01767 10.3389/fimmu.2020.01549 10.1038/s41591-018-0136-1 10.1038/sj.cdd.4400711
BMC Neurology; Li L, Yang Z et. al.

May 26th, 2022 - Glioma is the most common brain tumor in adults and is characterized by a short survival time and high resistance to chemotherapy. It is imperative to determine the prognosis and therapy-related targets for glioma. Endoplasmic reticulum stress (ERS), as an adaptive protective mechanism, indicates the unfolded protein response (UPR) to determine cell survival and affects chemotherapy sensitivity...

Differing clinical features between Japanese siblings with cerebrotendinous xanthomatos...
https://doi.org/10.1186/s12883-022-02711-4 10.1016/S0021-9258(20)89518-0 10.1093/brain/123.5.908 10.1111/j.1468-1331.2011.03439.x 10.1007/s10545-013-9674-3 10.1186/s13023-014-0179-4 10.1007/s10545-017-0093-8 10.1007/s10545-018-0152-9 10.1016/j.jacl.2018.06.008 10.1038/s10038-017-0389-4 10.1056/NEJM198412273112601 10.1007/s004310050818 10.1097/WNF.0b013e318288076a 10.1212/WNL.0000000000006731 10.1007/s10072-006-0618-7 10.1038/gim.2015.30 10.1212/WNL.46.2.571 10.1016/j.ejmg.2011.08.003 10.1007/s10072-016-2776-6 10.1007/s00415-019-09377-y 10.1007/s00415-017-8440-0
BMC Neurology; Koyama S, Okabe Y et. al.

May 26th, 2022 - Cerebrotendinous xanthomatosis (CTX) is an autosomal-recessive lipid storage disorder caused by mutations in the CYP27A1 gene encoding the key enzyme in the bile acid synthesis, sterol 27-hydroxylase. Here, we report two Japanese CTX siblings with a novel compound heterozygous CYP27A1 mutation, showing different clinical phenotypes and responses to chenodeoxycholic acid (CDCA) therapy. The prob...

Failure of crizotinib based systemic treatment in ALK positive histiocytosis involving ...
https://doi.org/10.1186/s12887-022-03368-1 10.1182/blood-2008-03-147017 10.1038/s41379-018-0168-6 10.1007/s00401-019-02027-7 10.1177/1066896920976862 10.1097/PAS.0000000000001567 10.3324/haematol.2019.230094 10.1080/10428194.2020.1861273 10.1159/000508524 10.1177/1093526617740784 10.21037/apm-21-2117 10.1007/s00428-021-03092-8 10.1182/blood.2021013338 10.1111/nan.12739 10.1158/2159-8290.CD-15-0913 10.1038/s41591-019-0653-6 10.1634/theoncologist.2016-0488 10.1242/dev.114769 10.1007/s40265-013-0142-z 10.1016/S1470-2045(15)00614-2 10.3171/jns.1998.88.3.0485 10.1155/2010/743784 10.1186/s12893-019-0489-5
BMC Pediatrics; He Q, Zhang W et. al.

May 26th, 2022 - Among the histiocytic disorders, anaplastic lymphoma kinase (ALK)-positive histiocytosis emerged in 2008. As more and more cases of the novel entity are reported, our understanding of it is deepened. However, only a few cases with central nervous system (CNS) involvement have been reported. Furthermore, the lesion in the suprasellar region has not been documented.  CASE PRESENTATION: We present...

Emergence of multi-drug-resistant Mycobacterium tuberculosis in Niger: A snapshot based...
https://doi.org/10.1371/journal.pntd.0010443
PLoS Neglected Tropical Diseases; Harouna Hamidou Z, Morsli M et. al.

May 26th, 2022 - Among other West African countries experiencing the high endemicity of deadly tuberculosis, the situation in Niger is poorly evidenced by microbiological investigations. The study of 42 isolates of Mycobacterium tuberculosis from Niger by whole genome sequencing using Illumina iSeq technology yielded four M. tuberculosis lineages: Indo-Oceanic L1 (n = 1) (2.3%), East-Asian (n = 1) (2.3%), East-...

Proteomic and microbiota analyses of the oral cavity during psychological stress.
https://doi.org/10.1371/journal.pone.0268155
PloS One; Paudel D, Kuramitsu Y et. al.

May 26th, 2022 - Psychological stress is associated with various oral diseases such as aphthous stomatitis, oral lichen planus, taste disturbances and glossodynia. However, the underlying mechanism is still unknown. The aim of this study was to determine the effect of psychological stress on salivary proteins and the oral microbiota in a rat model of chronic restraint stress. Six-week-old Sprague Dawley rats we...

7th Update on Fabry Disease: Biomarkers, Progression and Treatment Opportunities in 2022.
https://doi.org/10.1159/000524933
Nephron Warnock DG

May 26th, 2022 - no abstract.

Relative Telomere Length Is Associated With Age-Related Macular Degeneration in Women.
https://doi.org/10.1167/iovs.63.5.30
Investigative Ophthalmology & Visual Science; Koller A, Brandl C et. al.

May 26th, 2022 - Relative telomere length (RTL) is a biomarker for physiological aging. Premature shortening of telomeres is associated with oxidative stress, which is one possible pathway that might contribute to age-related macular degeneration (AMD). We therefore aimed to investigate the association between RTL and AMD in a well-characterized group of elderly individuals. We measured RTL in participants of t...

The use of a chimeric antigen for Plasmodium falciparum and P. vivax seroprevalence est...
https://doi.org/10.1371/journal.pone.0263485
PloS One; McCaffery JN, Singh B et. al.

May 26th, 2022 - In low-transmission settings, accurate estimates of malaria transmission are needed to inform elimination targets. Detection of antimalarial antibodies provides exposure history, but previous studies have mainly relied on species-specific antigens. The use of chimeric antigens that include epitopes from multiple species of malaria parasites in population-based serological surveys could provide ...

Antibiotic resistance in chronic respiratory diseases: from susceptibility testing to t...
https://doi.org/10.1183/16000617.0259-2021
European Respiratory Review : an Official Journal of the ... Pailhoriès H, Herrmann JL et. al.

May 26th, 2022 - The development of resistome analysis, i.e. the comprehensive analysis of antibiotic-resistance genes (ARGs), is enabling a better understanding of the mechanisms of antibiotic-resistance emergence. The respiratory microbiome is a dynamic and interactive network of bacteria, with a set of ARGs that could influence the response to antibiotics. Viruses such as bacteriophages, potential carriers o...

Gene alternation of cerebrospinal fluid in patients with leptomeningeal metastases of l...
https://doi.org/10.1186/s12885-022-09597-y 10.3322/caac.21660 10.1016/j.jtho.2016.06.029 10.1093/neuonc/nox077 10.1002/1878-0261.12574 10.1093/annonc/mdy009 10.1001/jamanetworkopen.2020.9077 10.1158/1078-0432.CCR-17-1582 10.1007/s00432-020-03340-5 10.1016/j.lungcan.2017.01.011 10.1016/j.lungcan.2019.03.019 10.1158/2159-8290.CD-15-0369 10.1016/j.jtho.2020.10.008 10.1164/rccm.201902-0294OC 10.1038/s41598-020-76791-y 10.1200/JCO.2016.66.6487 10.1038/s41588-020-0592-7 10.1002/path.4583
BMC Cancer; Yang H, Wen L et. al.

May 26th, 2022 - Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) provide a better prognosis in EGFR-mutant non-small cell lung cancer (NSCLC). Nevertheless, the outcome of leptomeningeal metastasis (LM) remains poor. In addition, due to limited access to intracranial tumour tissue, gene alterations associated with leptomeningeal metastasis from lung adenocarcinoma (LM-LUAD) are unclear. ...

Recommendations for environmental risk assessment of gene drive applications for malari...
https://doi.org/10.1186/s12936-022-04183-w 10.1098/rspb.2002.2319 10.1080/23299460.2017.1419410 10.1080/20477724.2018.1438880 10.4269/ajtmh.18-0083 10.1186/s12919-018-0112-2 10.1089/vbz.2019.2606 10.1186/s12936-021-03674-6 10.1371/journal.pntd.0007863 10.12688/wellcomeopenres.16023.1 10.1186/s12919-018-0111-3 10.1016/j.foodpol.2013.09.006 10.1073/pnas.1434337100 10.1038/nbt.4245 10.1080/07388551.2021.1933891 10.1016/j.envsci.2011.08.006 10.15252/embr.201540874 10.4161/gmcr.22906 10.1017/9781316585269.004 10.1186/s12936-019-2978-5 10.1007/s11248-013-9760-1 10.1007/s11248-009-9321-9 10.1051/ebr:2006018 10.1038/nbt1381 10.1186/s12915-020-00834-z 10.1002/2017EF000680 10.1007/s00425-020-03372-8 10.1080/23299460.2017.1415585 10.1007/s10530-012-0392-9 10.1002/ieam.1800 10.1016/j.tibtech.2020.08.011 10.1007/s10144-018-0628-3 10.1111/ele.13292 10.1016/j.biocon.2009.12.004 10.1086/419172 10.1016/S0304-3800(01)00499-9 10.1126/science.1214915 10.1038/ncomms13965 10.1016/j.biocon.2010.05.018 10.1111/risa.13383 10.1038/510218b 10.1038/s41467-021-24790-6
Malaria Journal; Connolly JB, Mumford JD et. al.

May 26th, 2022 - Building on an exercise that identified potential harms from simulated investigational releases of a population suppression gene drive for malaria vector control, a series of online workshops identified nine recommendations to advance future environmental risk assessment of gene drive applications.

Transcriptomics-Based Investigation of Molecular Mechanisms Underlying Apoptosis Induce...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124502
International Journal of Nanomedicine; Alsagaby SA

May 26th, 2022 - Zinc oxide nanoparticles (ZnO NPs) show anti-cancer activity. Diffuse Large B-cell Lymphoma (DLBCL) is a type of B-cell malignancies with unsatisfying treatment outcomes. This study was set to assess the potential of ZnO NPs to selectively induce apoptosis in human DLBCL cells (OCI-LY3), and to describe possible molecular mechanisms of action. The impact of ZnO NPs on DLBCL cells and normal per...

Biological and Immune Responses to Current Anti-SARS-CoV-2 mRNA Vaccines beyond Anti-Sp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124111
Journal of Immunology Research; Federico M

May 25th, 2022 - Several vaccine strategies are now available to fight the current SARS-CoV-2 pandemic. Those based on the administration of lipid-complexed messenger(m)RNA molecules represent the last frontiers in terms of technology innovation. mRNA molecules coding for the SARS-CoV-2 Spike protein are intramuscularly injected, thereby entering cells by virtue of their encapsulation into synthetic lipid nanov...

Hypoxia Promotes Glioma Stem Cell Proliferation by Enhancing the 14-3-3β Expression via...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124136
Journal of Immunology Research; Cao W, Zhou Q et. al.

May 25th, 2022 - Glioma is a serious fatal type of cancer with the shorter median survival period and poor quality of living. The overall 5-year survival rate remains low due to high recurrence rates. Glioma stem cells (GSCs) play the important roles in the development of gliomas. Examination of the numerous biomarkers or cancer-associated genes involved in the development or prevention of glioma may therefore ...