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About 218,643 results

Risk classification at diagnosis predicts post-HCT outcomes in AML
https://www.mdedge.com/hematology-oncology/article/247827/aml/risk-classification-diagnosis-predicts-post-hct-outcomes-aml

Oct 24th, 2021 - Key clinical point: Risk classification at acute myeloid leukemia (AML) diagnosis predicted clinical outcomes in patients with or without KMT2A-rearranged AML who underwent allogeneic hematopoietic cell transplant (HCT) in the first complete remission (CR1). Major finding: Transplanted patients with KMT2A-rearranged and adverse-risk AML had worse overall survival (hazard ratio [HR] 1.

Autism Spectrum Disorder and Prenatal or Early Life Exposure to Pesticides: A Short Rev...
https://doi.org/10.3390/ijerph182010991
International Journal of Environmental Research and Publi... Miani A, Imbriani G et. al.

Oct 24th, 2021 - Background: Autism spectrum disorder (ASD) diagnoses have rapidly increased globally. Both environmental and genetic factors appear to contribute to the development of ASD. Several studies have shown a potential association between prenatal or postnatal pesticide exposure and the risk of developing ASD. Methods: We reviewed the available literature concerning the relationship between early life...

First- and Third-Trimester Urinary Phthalate Metabolites in the Development of Hyperten...
https://doi.org/10.3390/ijerph182010627
International Journal of Environmental Research and Publi... Bedell SM, Lyden GR et. al.

Oct 24th, 2021 - The purpose of this study was to determine whether maternal urinary phthalate metabolite concentrations are associated with the development of higher blood pressure or pregnancy-induced hypertension (PIH). Participants were women without chronic hypertension who enrolled in The Infant Development and the Environment Study, a prospective pregnancy cohort conducted at four U.S. academic medical c...

Symptoms of Autism, Comorbid Mental Health Conditions and Challenging Behaviors among T...
https://doi.org/10.3390/ijerph182010684
International Journal of Environmental Research and Publi... Pisula E, Niedźwiecka A

Oct 24th, 2021 - Background: Autism spectrum disorder (ASD) may coexist with Down syndrome (DS). Most studies on this topic involve school-age children, adolescents, or adults with DS. This study looked at ASD symptoms, other mental health problems, and challenging behaviors in toddlers with DS at low risk of ASD. Methods: We used screening tools for autism in toddlers; BISCUIT-Parts 1-3 and Q-CHAT. We compared...

The characteristics and factors of the internalizing and externalizing behaviours of ch...
https://doi.org/10.1186/s12888-021-03479-6 10.1001/jama.2014.9841 10.1016/j.cub.2005.09.033 10.1016/j.ridd.2015.08.006 10.1038/nature21369 10.3389/fpsyg.2017.02004 10.1016/j.rasd.2016.04.002 10.1007/s10803-010-0958-2 10.1016/j.ridd.2014.02.012 10.1111/j.1469-7610.2010.02295.x 10.3109/00048674.2010.534071 10.1007/s10803-009-0736-1 10.1007/s10802-018-0410-1 10.1034/j.1600-0447.2000.102005321.x 10.1007/s10882-011-9231-7 10.1017/S0954579416000043 10.1007/s10803-008-0555-9 10.1007/s10802-009-9342-0 10.1037/a0020659 10.1002/aur.131 10.1023/B:JADD.0000029554.46570.68 10.1007/s10803-017-3459-8 10.1037/0012-1649.35.6.1399 10.1177/1362361310366571 10.1111/j.1365-2788.2005.00732.x 10.1111/j.1469-7610.1990.tb00834.x 10.1111/j.1440-1819.1987.tb00407.x 10.1176/ajp.142.12.1450 10.1016/j.ijdevneu.2004.05.001 10.1111/j.1469-7610.2007.01860.x 10.1016/j.braindev.2012.10.004 10.1023/A:1010799320795 10.1007/s10803-013-2028-z 10.1037/0003-066X.44.2.329 10.1081/JA-120034011 10.1037/0022-006X.64.1.64 10.1007/s10803-010-1015-x 10.1177/1362361319830042 10.1007/s10803-017-3375-y 10.1017/s0954579404044530 10.1007/s10803-007-0450-9 10.1007/BF02211841 10.1007/BF02172145 10.1111/j.1469-7610.1980.tb01797.x 10.1007/BF00913694 10.1007/s10803-006-0299-3 10.1207/s15326888chc1102_5 10.1111/j.1467-8624.1997.tb01967.x 10.3102/00028312039001133 10.1016/S0163-6383(03)00035-3 10.1177/1362361309105658 10.1111/j.1467-9507.2009.00543.x 10.1016/S0891-4222(03)00014-3 10.1111/dmcn.12830 10.3390/ijerph16020262 10.1002/aur.2061 10.1002/(SICI)1098-2302(199703)30:2<127::AID-DEV4>3.0.CO;2-S 10.1111/jcpp.12710 10.1177/1362361318766571 10.1016/j.cpr.2008.11.001 10.1016/j.jaac.2018.07.872 10.1017/S0954579416000298 10.3390/bs7010002 10.1177/1362361312458039
BMC Psychiatry; Ding N, Gao H et. al.

Oct 24th, 2021 - The behavioral characteristics of children with autism spectrum disorder (ASD) are not only affected by their disease, but also by their parenting environment. HR-ASD has the risk of developing internalization and externalization problems. How the early development of these behavioral problems is affected by parent-child interaction is worth exploring. We tested whether parent-child interaction...

MiR-425-5p accelerated the proliferation, migration, and invasion of ovarian cancer cel...
https://doi.org/10.1186/s13048-021-00894-x 10.1111/j.1601-5037.2006.00177.x 10.1038/sigtrans.2015.4 10.1177/0004563216649377 10.1016/j.biocel.2019.04.004 10.18632/oncotarget.15208 10.1093/nar/gkx247 10.18632/oncotarget.12045 10.1186/s13046-019-1103-5 10.1093/bioinformatics/bts344 10.1016/j.ygyno.2013.09.034 10.1186/s13027-019-0238-5 10.1002/jcp.29360 10.1016/j.gpb.2015.09.006 10.2147/CMAR.S232140 10.1186/s12943-018-0870-5 10.7150/jca.49557 10.1080/15384101.2020.1783058 10.1002/kjm2.12148 10.3233/CBM-190782 10.1186/s12890-020-01261-0 10.1038/boneres.2017.44 10.1074/jbc.M112.367854 10.1093/carcin/bgy046 10.1016/j.yexcr.2020.112445 10.1038/s41388-019-0683-z 10.1002/jcb.29476
Journal of Ovarian Research; Wu Z, Guo J et. al.

Oct 24th, 2021 - Accumulating data have established that microRNAs (miRNAs) play significant regulatory roles in the carcinogenesis and progression of ovarian cancer (OC). MiR-425-5p was reported to function in various tumors. However, the roles and underlying mechanism of miR-425-5p involvement in OC development and progression are unclear. A comprehensive strategy of data mining, computational biology, and re...

Activation of Notch and Myc signaling via B cell-restricted depletion of Dnmt3a generat...
https://doi.org/10.1158/0008-5472.CAN-21-1273
Cancer Research; Biran A, Yin S et. al.

Oct 24th, 2021 - Chronic lymphocytic leukemia (CLL) is characterized by disordered DNA methylation, suggesting these epigenetic changes might play a critical role in disease onset and progression. The methyltransferase DNMT3A is a key regulator of DNA methylation. Although DNMT3A somatic mutations in CLL are rare, we found that low DNMT3A expression is associated with more aggressive disease. A conditional knoc...

Close Association Between Altered Urine-urothelium Barrier and Tertiary Lymphoid Struct...
https://doi.org/10.1681/ASN.2021040575
Journal of the American Society of Nephrology : JASN; Ichii O, Hosotani M et. al.

Oct 24th, 2021 - Background: Kidneys with chronic inflammation develop tertiary lymphoid structures (TLSs). Infectious pyelonephritis is characterized by renal pelvis (RP) inflammation. However, the pathological features of TLSs, including their formation and association with non-infectious nephritis, are unclear. Methods: RPs from humans and mice that were healthy or had non-infectious chronic nephritis, were ...

On-treatment gamma-glutamyl transferase predicts the development of hepatocellular carc...
https://doi.org/10.1111/liv.15085
Liver International : Official Journal of the Internation... Huang CF, Tyng-Yuan J et. al.

Oct 24th, 2021 - Gamma-glutamyl transferase (GGT) has been predictive of chronic hepatitis C-related hepatocellular carcinoma (HCC) development. Its role in the risk of HCC in chronic hepatitis B (CHB) patients treated with nucleotide/nucleoside analogues (NAs) is elusive. A total of 2,172 CHB patients from East Asia were randomized into development and validation groups in a 1:2 ratio. Serum GGT levels before ...

Comparisons of two definitions of Bronchopulmonary Dysplasia for the premature infants.
https://doi.org/10.1002/ppul.25739
Pediatric Pulmonology; Li J, Xu H

Oct 24th, 2021 - Bronchopulmonary dysplasia (BPD) is a very common respiratory disease in premature infants, but there is still a different understanding of the definition of BPD. Therefore, this study is intended to compare ar main clinical results and health economic expenditures under different BPD definitions. This study included premature infants who came into the neonatal intensive care unit (NICU) from J...

ERAP1 as an emerging therapeutic target for medulloblastoma.
https://doi.org/10.1016/j.trecan.2021.09.005
Trends in Cancer; Bufalieri F, Fruci D et. al.

Oct 24th, 2021 - Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme that shapes the peptide repertoire presented by major histocompatibility complex class I (MHC-I) molecules, thereby affecting tumor immunogenicity. ERAP1 is altered in many tumors, including medulloblastoma (MB). We review the role of ERAP1 in MB development and the possibility of targeting this enzyme for MB treatment.

Targeting miR-126 in inv(16) acute myeloid leukemia inhibits leukemia development and l...
https://doi.org/10.1038/s41467-021-26420-7 10.1053/j.seminoncol.2008.04.016 10.1053/j.seminhematol.2015.04.004 10.1182/blood-2016-10-696054 10.1182/blood-2016-10-696039 10.1182/blood-2016-08-733196 10.1002/(SICI)1098-2264(199606)16:2<77::AID-GCC1>3.0.CO;2-# 10.1016/S0268-960X(03)00040-7 10.1038/sj.onc.1207763 10.1038/nrc840 10.1126/science.8351518 10.1200/JCO.2008.21.0674 10.1038/nature02871 10.1016/S0092-8674(04)00045-5 10.1261/rna.5167604 10.1126/science.1090599 10.1038/nrm3838 10.1126/science.1091903 10.1016/j.devcel.2008.07.002 10.1016/j.devcel.2008.07.008 10.1016/j.stem.2012.09.001 10.1073/pnas.0808266105 10.1182/blood-2008-01-133355 10.1182/blood-2007-07-098749 10.1007/s11899-009-0012-7 10.1158/0008-5472.CAN-13-1733 10.1016/j.ccell.2016.03.015 10.1038/nm.4499 10.1016/j.ccr.2005.12.014 10.1182/blood-2016-01-693119 10.1242/dev.029736 10.1038/nature02416 10.1182/blood-2017-03-771386 10.1002/stem.1309 10.1038/s41375-019-0605-7 10.1161/CIRCULATIONAHA.116.022478 10.1371/journal.pone.0012156 10.1093/bib/bbn016 10.1101/gr.249789.119 10.1038/s41467-020-14743-w 10.1161/ATVBAHA.110.211706 10.1016/j.stem.2015.08.004 10.1093/nar/gkg318 10.1002/jcp.26951 10.1016/j.tcb.2004.02.006 10.1073/pnas.1505995112 10.1182/blood-2007-07-104422 10.3892/ijo.2014.2516 10.1038/35088082 10.1016/j.neuron.2011.02.004 10.1101/gad.836800 10.1371/journal.pgen.0030146 10.1073/pnas.050586197 10.1073/pnas.0806879105 10.1101/gad.1067003 10.1016/j.cell.2018.08.014 10.1182/blood-2015-04-639062 10.1038/leu.2013.257 10.1182/blood.2020007747 10.1016/j.ccell.2016.05.007 10.1038/13776 10.1182/blood-2006-10-051508 10.1182/blood-2008-06-162248 10.1126/science.7660125 10.1073/pnas.0506580102
Nature Communications; Zhang L, Nguyen LXT et. al.

Oct 24th, 2021 - Acute myeloid leukemia (AML) harboring inv(16)(p13q22) expresses high levels of miR-126. Here we show that the CBFB-MYH11 (CM) fusion gene upregulates miR-126 expression through aberrant miR-126 transcription and perturbed miR-126 biogenesis via the HDAC8/RAN-XPO5-RCC1 axis. Aberrant miR-126 upregulation promotes survival of leukemia-initiating progenitors and is critical for initiating and mai...

Relationships between retinopathy of prematurity without ophthalmologic intervention an...
https://doi.org/10.1038/s41390-021-01778-y 10.1016/j.ophtha.2014.07.050 10.1016/j.jaapos.2014.01.014 10.1001/jamaophthalmol.2013.5812 10.1001/jamaophthalmol.2016.0391 10.1001/jama.2013.282153 10.1136/archdischild-2016-312533 10.1542/peds.2018-3537 10.1001/jama.2018.14996 10.1177/0734282906297199 10.1111/j.1469-8749.1997.tb07414.x 10.1016/0029-7844(95)00386-X 10.1016/S0022-3476(78)80282-0 10.1111/aos.13631 10.1212/01.wnl.0000437298.43688.b9 10.1159/000487847 10.1038/sj.jp.7211228 10.1542/peds.106.5.998 10.1111/jnp.12069 10.1542/peds.2017-0257 10.1542/peds.2015-4343 10.1001/archopht.123.3.311
Pediatric Research; Brumbaugh JE, Bell EF et. al.

Oct 24th, 2021 - Severe retinopathy of prematurity (ROP) is associated with adverse outcomes. Relationships between milder ROP and outcomes have not been defined. We hypothesized that children with ROP stage ≤3 who did not receive ophthalmologic intervention would have worse motor, cognitive, and language skills and more vision abnormalities than children without ROP. This was a secondary analysis of a randomiz...

Application of comprehensive bioinformatics approaches to reconnoiter crucial genes and...
https://doi.org/10.1007/s12032-021-01576-w 10.1002/hep.31288 10.1016/j.jceh.2014.05.013 10.1097/MOG.0000000000000626 10.1155/2017/5728946 10.1097/MD.0000000000006938 10.1016/j.biopha.2018.11.127 10.1002/hep.21622 10.1016/j.cyto.2015.11.011 10.1016/j.jhep.2012.01.029 10.3390/ijms161023683 10.5001/omj.2020.21 10.1016/j.cyto.2019.02.006 10.1038/sj.bjc.6603061 10.1038/s41467-019-12393-1 10.1186/1476-9255-9-39 10.2147/CMAR.S248539 10.1038/s41417-019-0109-7 10.1158/1078-0432.CCR-14-1936 10.3892/ol.2020.11844 10.1002/jcp.26816 10.1016/j.ecl.2012.04.014 10.4061/2011/523420 10.3390/cancers7010179 10.1038/sj.onc.1210799 10.1002/1098-2264(2000)9999:9999<::AID-GCC1044>3.0.CO;2-N 10.21873/anticanres.13341 10.1186/s12935-019-0956-1 10.1186/s12935-020-01191-1 10.3390/cancers13092232 10.3892/ijmm.2017.3079 10.1016/j.celrep.2017.11.033 10.2174/1568009614666140804154511 10.18632/oncotarget.13760 10.1111/bph.12045 10.1016/j.leukres.2014.06.005
Medical Oncology (Northwood, London, England); Nair G, Hema Sree GNS et. al.

Oct 24th, 2021 - Hepatocellular carcinoma (HCC) is the fifth most common neoplasm in the world. Chronic inflammation of liver and associated wound healing processes collectively contribute to the development of cirrhosis which further progresses to dysplastic nodule and then to HCC. Etiological mediators and ongoing manipulations at cellular level in HCC are well established; however, key protein interactions a...

Regulation of autophagy as a therapeutic option in glioblastoma.
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Apoptosis : an International Journal on Programmed Cell D... Manea AJ, Ray SK

Oct 24th, 2021 - Around three out of one hundred thousand people are diagnosed with glioblastoma multiforme, simply called glioblastoma, which is the most common primary brain tumor in adults. With a dismal prognosis of a little over a year, receiving a glioblastoma diagnosis is oftentimes fatal. A major advancement in its treatment was made almost two decades ago when the alkylating chemotherapeutic agent temo...

Glioma: molecular signature and crossroads with tumor microenvironment.
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Cancer Metastasis Reviews; Barthel L, Hadamitzky M et. al.

Oct 24th, 2021 - In patients with glioblastoma, the average survival time with current treatments is short, mainly due to recurrences and resistance to therapy. This insufficient treatment success is, in large parts, due to the tremendous molecular heterogeneity of gliomas, which affects the overall prognosis and response to therapies and plays a vital role in gliomas' grading. In addition, the tumor microenvir...

Surgical technique and the long-term outcomes of pediatric living donor domino liver tr...
https://doi.org/10.1111/petr.14174
Pediatric Transplantation; Shimizu S, Sakamoto S et. al.

Oct 24th, 2021 - The native liver of patients with maple syrup urine disease (MSUD) (1st recipients) can be used as a graft for non-MSUD patients with end-stage liver disease (2nd recipients). This study aimed to demonstrate the optimal operational procedures and the long-term outcomes of 2nd recipients. Six 2nd recipients of living donor domino liver transplantation (LD-DLT) (age: 42.5 [22-169] months at DLT) ...

Induction of IL-6Rα by ATF3 enhances IL-6 mediated sorafenib and regorafenib resistance...
https://doi.org/10.1016/j.canlet.2021.10.024
Cancer Letters; Dai Z, Wang X et. al.

Oct 24th, 2021 - Sorafenib and its derivative regorafenib are the first- and second-line targeted drugs for advanced HCC, respectively. Although both drugs improve overall survival, drug resistance remains the major barrier to their full efficacy. Thus, strategies to enhance sorafenib and regorafenib efficacy against HCC are solely needed. Interleukin-6 receptor alpha (IL-6Rα) is the receptor of IL-6, a multi-f...

Single dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T c...
https://doi.org/10.1016/j.ymthe.2021.10.008
Molecular Therapy : the Journal of the American Society O... Boulton S, Poutou J et. al.

Oct 24th, 2021 - The coronavirus disease 2019 (COVID-19) pandemic requires the continued development of safe, long-lasting, and efficacious vaccines for preventative responses to major outbreaks around the world, and especially in isolated and developing countries. To combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we characterize a temperature-stable vaccine candidate (TOH-Vac1) that uses ...

Development and validation of the discomfort of cloth Masks-12 (DCM-12) scale.
https://doi.org/10.1016/j.apergo.2021.103616
Applied Ergonomics; Mumma JM, Jordan E et. al.

Oct 24th, 2021 - During the COVID-19 pandemic, the use of face masks by the public has helped to slow the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the community. Cloth masks have been recommended because of their effectiveness, availability, and reusability. Like other types of face masks, however, user discomfort while wearing cloth masks is thought to engender behaviors that l...