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About 310,513 results

Lower bevacizumab doses, agents with less systemic exposure may be safer options for ROP
https://www.healio.com/news/ophthalmology/20220203/lower-bevacizumab-doses-agents-with-less-systemic-exposure-may-be-safer-options-for-rop

Feb 3rd, 2022 - WAIKOLOA, Hawaii — Systemic effects of anti-VEGF in retinopathy of prematurity have not been ruled out, so it may be wise to use bevacizumab in lower doses or switch to agents with less systemic exposure, according to one presenter. “The BEAT-ROP study demonstrated a beneficial effect for bevacizumab vs. laser in the treatment of zone I, stage 3+ ROP. But one thing I didn’t like was the complet...

Natural History and Development of Spondyloarthritis
https://clinicaltrials.gov/ct2/show/NCT01422694

Jan 13th, 2023 - The purpose of this protocol is to study the natural history of spondyloarthritis (SpA) in children and adults. Spondyloarthritis encompasses a spectrum of immune-mediated inflammatory diseases that exhibit overlapping features, but differ from other types of inflammatory arthritis in genetic predisposition, pathogenesis, and outcome. Ankylosing spondylitis (AS), the most common form of SpA, fr...

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
https://doi.org/10.1002/art.41752
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

2019 Update of the American College of Rheumatology/Spondylitis Association of America/...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764882
Arthritis & Rheumatology (Hoboken, N.J.); Ward MM, Deodhar A et. al.

Aug 23rd, 2019 - To update evidence-based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA). We conducted updated systematic literature reviews for 20 clinical questions on pharmacologic treatment addressed in the 2015 guidelines, and for 26 new questions on pharmacologic treatment, treat-to-target strategy, and use of imaging. New q...

Three nervous system-specific expressed genes are potential biomarkers for the diagnosi...
https://doi.org/10.1186/s12920-023-01441-x
BMC Medical Genomics; Liao Y, Cai H et. al.

Jan 29th, 2023 - Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease in adults. However, ALS, especially sporadic ALS (sALS), is difficult to diagnose due to the lack of biomarkers. We used the bioinformatics technology to find the potential biomarker and we found that two hundred seventy-four DEGs were identified and enrichment analysis showed DEGs were involved in nervous system a...

Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upr...
https://doi.org/10.1186/s13024-023-00597-5
Molecular Neurodegeneration; Kisler K, Sagare AP et. al.

Jan 29th, 2023 - PICALM is one of the most significant susceptibility factors for Alzheimer's disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium. PICALM endothelial levels are reduced in AD brains. PICALM controls several steps in Aβ transcytosis across the blood-brain barrier (BBB). Its loss from brain endothelium in mice diminishes Aβ clearance at the BBB, which worsens Aβ patho...

Quantitative systems pharmacology of the eye: Tools and data for ocular QSP.
https://doi.org/10.1002/psp4.12918
CPT: Pharmacometrics & Systems Pharmacology; Kuepfer L, Fuellen G et. al.

Jan 29th, 2023 - Good eyesight belongs to the most-valued attributes of health, and diseases of the eye are a significant healthcare burden. Case numbers are expected to further increase in the next decades due to an aging society. The development of drugs in ophthalmology, however, is difficult due to limited accessibility of the eye, in terms of drug administration and in terms of sampling of tissues for drug...

Assessment of the efficacy and tolerability of ruxolitinib for the treatment of myelofi...
https://doi.org/10.1002/cam4.5618
Cancer Medicine; Coltro G, Sant'Antonio E et. al.

Jan 29th, 2023 - Incorporating real-world data in the drug development process allows the improvement of health outcomes by providing better representation of actual patterns of drug safety and efficacy. Here, we present the results of a retroprospective, observational real-life study of 154 patients with myelofibrosis treated with ruxolitinib in a real-life setting in seven Italian centers of the MYNERVA proje...

Preclinical pharmacokinetics and tolerability of a novel meglumine-based parenteral sol...
https://doi.org/10.1111/epi.17520
Epilepsia Rundfeldt C, Klein P et. al.

Jan 29th, 2023 - For an anti-seizure medication (ASM) to be effective in status epilepticus (SE), the drug should be administered intravenously (i.v.) to provide quick access to the brain. However, poor aqueous solubility is a major problem in the development of parenteral drug solutions. Given its multiple mechanisms of action, topiramate (TPM) is a promising candidate for the treatment of established or refra...

Infectious mononucleosis is associated with an increased incidence of Crohn's disease: ...
https://doi.org/10.1097/MEG.0000000000002505
European Journal of Gastroenterology & Hepatology; Loosen SH, Kostev K et. al.

Jan 29th, 2023 - The pathogenesis of inflammatory bowel disease (IBD) has not been fully uncovered to date. Epstein-Barr-Virus (EBV) infection has recently been associated with the pathogenesis of multiple sclerosis, suggesting a general link between EBV and autoimmune diseases. However, data on an association between EBV and IBD have remained inconclusive. This study aims at evaluating an association between E...

Development and validation of a model for predicting the adult height of girls with idi...
https://doi.org/10.1007/s00431-023-04842-3
European Journal of Pediatrics; Wu W, Zhu X et. al.

Jan 29th, 2023 - The aim was to develop a model to predict the adult height (AH) of idiopathic central precocious puberty (ICPP) girls who underwent gonadotropin-releasing hormone analog (GnRHa) treatment. Data analysis included 258 girls with ICPP. Among them, 101 girls who reached final AH (FAH) with GnRHa treatment were analyzed to verify three previous prediction models and develop a unique model based on m...

Histone methyltransferase SETD1A interacts with notch and promotes notch transactivatio...
https://doi.org/10.1186/s12885-023-10573-3
BMC Cancer; Chai H, Pan C et. al.

Jan 29th, 2023 - High expression of SETD1A, a histone methyltransferase that specifically methylates H3K4, acted as a key oncogene in several human cancers. However, the function and underlying molecular mechanism of SETD1A in ovarian cancer (OV) remain markedly unknown. The expression of SETD1A in OV were detected by Western blot and analyzed online, and the prognosis of STED1A in OV were analyzed online. The ...

Patient-level performance evaluation of a smartphone-based malaria diagnostic application.
https://doi.org/10.1186/s12936-023-04446-0
Malaria Journal; Yu H, Mohammed FO et. al.

Jan 29th, 2023 - Microscopic examination is commonly used for malaria diagnosis in the field. However, the lack of well-trained microscopists in malaria-endemic areas impacted the most by the disease is a severe problem. Besides, the examination process is time-consuming and prone to human error. Automated diagnostic systems based on machine learning offer great potential to overcome these problems. This study ...

Molecular evolution of the human monkeypox virus.
https://doi.org/10.1002/jmv.28533
Journal of Medical Virology; Wolf JM, Wolf LM et. al.

Jan 29th, 2023 - Recently, in 2022, new cases of human monkeypox virus (hMPXV) occurred in Europe and North America. The first case was reported in Europe in May 2022, and subsequently, more than 50,000 new cases were confirmed in 100 countries. Currently, the classification of hMPXV according to the nextstrain occurs in five big clades (1A, A.1, A.2, A.1.1, and B.1). According to the resurgence of smallpox-lik...

The Poly (ADP-ribose) polymerase inhibitor olaparib and pan-ErbB inhibitor neratinib ar...
https://doi.org/10.1016/j.ygyno.2023.01.015
Gynecologic Oncology; Han C, McNamara B et. al.

Jan 28th, 2023 - Ovarian cancer (OC) is associated with the highest gynecologic cancer mortality. The development of novel, effective combinations of targeted therapeutics remains an unmet medical need. We evaluated the preclinical efficacy of the Poly (ADP-ribose) polymerase (PARP) inhibitor (olaparib) and the pan-ErbB inhibitor (neratinib) as single agents and in combination in ovarian cancer cell lines and x...

The comparative analysis of selected interleukins and proinflammatory factors in CSF am...
https://doi.org/10.1016/j.clineuro.2022.107522
Clinical Neurology and Neurosurgery; Morawiec N, Techmański T et. al.

Jan 28th, 2023 - Cytokines play a key role in neuroinflammation, which is present in every subset of multiple sclerosis (MS). The aim of the study was to assess levels of selected interleukins and proinflammatory factors in cerebrospinal fluid (CSF) among patients diagnosed with relapsing-remitting multiple sclerosis (RRMS). One hundred eighteen patients diagnosed de novo with RRMS were enrolled in the study. W...

Targeting caseinolytic protease P and its AAA1 chaperone for tuberculosis treatment.
https://doi.org/10.1016/j.drudis.2023.103508
Drug Discovery Today; Xu X, Zhang L et. al.

Jan 28th, 2023 - Caseinolytic protease P with its AAA1 chaperone, known as Mycobacterium tuberculosis (Mtb)ClpP1P2 proteolytic machinery, maintains protein homeostasis in Mtb cells and is essential for bacterial survival. It is regarded as an important biological target with the potential to address the increasingly serious issue of multidrug-resistant (MDR) TB. Over the past 10 years, many MtbClpP1P2-targeted ...

The impact of N-nitrosamine impurities on clinical drug development.
https://doi.org/10.1016/j.xphs.2023.01.017
Journal of Pharmaceutical Sciences; Paglialunga S, van Haarst A

Jan 28th, 2023 - Over the past few years, an increasing number of commercially available drugs have been reported to contain N-nitrosamine impurities above acceptable intake limits. Consequent interruption or discontinuation of the manufacturing and distribution of several marketed drugs has culminated into shortages of marketed drugs, including the antidiabetic drug metformin and the potentially life-saving dr...

Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific ...
https://doi.org/10.1038/s41467-023-36083-1
Nature Communications; Pan S, Yang PH et. al.

Jan 28th, 2023 - Cerebrospinal fluid (CSF) is essential for the development and function of the central nervous system (CNS). However, the brain and its interstitium have largely been thought of as a single entity through which CSF circulates, and it is not known whether specific cell populations within the CNS preferentially interact with the CSF. Here, we develop a technique for CSF tracking, gold nanoparticl...

Towards the development of subunit vaccines against tuberculosis: The key role of adjuv...
https://doi.org/10.1016/j.tube.2023.102307
Tuberculosis (Edinburgh, Scotland); Duong VT, Skwarczynski M et. al.

Jan 28th, 2023 - According to the World Health Organization (WHO), tuberculosis (TB) is the leading cause of death triggered by a single infectious agent, worldwide. Bacillus Calmette-Guerin (BCG) is the only currently licensed anti-TB vaccine. However, other strategies, including modification of recombinant BCG vaccine, attenuated Mycobacterium tuberculosis (Mtb) mutant constructs, DNA and protein subunit vacc...