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Lower bevacizumab doses, agents with less systemic exposure may be safer options for ROP
https://www.healio.com/news/ophthalmology/20220203/lower-bevacizumab-doses-agents-with-less-systemic-exposure-may-be-safer-options-for-rop

Feb 3rd, 2022 - WAIKOLOA, Hawaii — Systemic effects of anti-VEGF in retinopathy of prematurity have not been ruled out, so it may be wise to use bevacizumab in lower doses or switch to agents with less systemic exposure, according to one presenter. “The BEAT-ROP study demonstrated a beneficial effect for bevacizumab vs. laser in the treatment of zone I, stage 3+ ROP. But one thing I didn’t like was the complet...

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
https://doi.org/10.1002/art.41752
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

Supportive management of patients with pheochromocytoma/paraganglioma undergoing noninv...
https://doi.org/10.1097/MED.0000000000000724
Current Opinion in Endocrinology, Diabetes, and Obesity; Talvacchio S, Nazari MA et. al.

May 28th, 2022 - Many publications review perioperative management of pheochromocytomas/paragangliomas (PPGLs); however, a large population, including 10-20% of metastatic PPGL patients, have inoperable disease. This has necessitated the development of noninvasive treatments (e.g., radio/chemotherapy), which, in affording disease-modification, have led to an ever-growing population of surviving patients with in...

Evaluating fostamatinib disodium as a treatment option for immune thrombocytopenia in a...
https://doi.org/10.1080/14656566.2022.2082283
Expert Opinion on Pharmacotherapy; Dierickx D, Neefs J

May 28th, 2022 - Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by increased platelet destruction and decreased platelet production, leading to thrombocytopenia with or without bleeding manifestations. The majority of patients experiencing treatment need will eventually need secondary treatment following first line therapy with steroids. In 2018, the oral spleen tyrosine kinase i...

Experiences of persons with Multiple Sclerosis with lifestyle adjustment-A qualitative ...
https://doi.org/10.1371/journal.pone.0268988
PloS One; Elkhalii-Wilhelm S, Sippel A et. al.

May 28th, 2022 - Persons with Multiple Sclerosis (pwMS) follow individual strategies to cope with this highly heterogeneous disease. As surveys show, lifestyle habits play an important role in pwMS. However, little is known about individual experiences of pwMS with different lifestyle adjustment strategies. This study aims to describe and understand individual experiences of pwMS with lifestyle adjustments. Sem...

Understanding of the transition to adult healthcare services among individuals with VAC...
https://doi.org/10.1371/journal.pone.0269163
PloS One; Kassa AM, Engvall G et. al.

May 28th, 2022 - Current knowledge of transitional care from the perspective of individuals with congenital malformations is scarce. Their viewpoints are required for the development of follow-up programs and transitional care corresponding to patients' needs. The study aimed to describe expectations, concerns, and experiences in conjunction with transfer to adult health care among adolescents, young adults, an...

HERVs role in the pathogenesis, diagnosis or prognosis of aging diseases: A systematic ...
https://doi.org/10.2174/1566524022666220525144135
Current Molecular Medicine; Prieto-Oliveir P

May 28th, 2022 - HERVs are humans endogenous retroviruses, which represent about 8% of human genome, and have various physiological functions, specially in pregnancy, embryo development and placenta formation. However, their involvement in diseases is not well defined. Some studies observed changes in HERVs expression according to age. Therefore, the aim of this systematic review was to analyze their role in pa...

Ferroptosis inhibitor regulates the disease progression of systematic lupus erythematos...
https://doi.org/10.2174/1566524022666220525144630
Current Molecular Medicine; Yang B, Hou S et. al.

May 28th, 2022 - Systematic lupus erythematosus (SLE) is an autoimmune-mediated disease. So far, there is no relevant report on ferroptosis in SLE research, and the role of T helper 1 (Th1) and T helper 2 (Th2) cells in SLE is still unclear. This study employed SLE mice models with and without ferroptosis inhibitors(Liproxstatin‑1) and normal control mice. Treated mice were zanalyzed with hematoxylin and eosin ...

Current Strategies for the Treatment of Hepatocellular Carcinoma by Modulating the Tumo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128750
International Journal of Nanomedicine; Huang Y, Wang T et. al.

May 28th, 2022 - Liver cancer remains a global health challenge with a projected incidence of over one million cases by 2025. Hepatocellular carcinoma (HCC) is a common primary liver cancer, accounting for about 90% of all liver cancer cases. The tumor microenvironment (TME) is the internal and external environment for tumor development, which plays an important role in tumorigenesis, immune escape and treatmen...

Intercellular Communication-Related Molecular Subtypes and a Gene Signature Identified ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127593
Disease Markers; Guan P, Cai W et. al.

May 28th, 2022 - The tumor microenvironment (TME) of lung adenocarcinoma (LUAD) comprise various cell types that communicate with each other through ligand-receptor interactions. This study focused on the identification of cell types in LUAD by single-cell RNA sequencing (scRNA-seq) data and screening of intercellular communication-related genes. The Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm....

A Mechanistic Insight into the Pathogenic Role of Interleukin 17A in Systemic Autoimmun...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129985
Mediators of Inflammation; Bisoendial R, Lubberts E

May 28th, 2022 - Interleukin 17A (IL-17A) has been put forward as a strong ally in our fight against invading pathogens across exposed epithelial surfaces by serving an antimicrobial immunosurveillance role in these tissues to protect the barrier integrity. Amongst other mechanisms that prevent tissue injury mediated by potential microbial threats and promote restoration of epithelial homeostasis, IL-17A attrac...

Application of the CT/MRI LI-RADS Treatment Response Algorithm to Contrast-Enhanced Ult...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128751
Journal of Hepatocellular Carcinoma; Ruan SM, Cheng MQ et. al.

May 28th, 2022 - The contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) treatment response algorithm (TRA) is still in development. The aim of this study was to explore whether the CT/MRI LI-RADS TRA features were applicable to CEUS in evaluating the liver locoregional therapy (LRT) response. This study was a retrospective review of a prospectively maintained database of patie...

Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for...
https://doi.org/10.1080/22221751.2022.2081619
Emerging Microbes & Infections; Li H, Han X et. al.

May 28th, 2022 - Cryptococcal meningoencephalitis (CM) is emerging as an infection in HIV/AIDS patients shifted from primarily ART- naive to ART-experienced individuals, as well as patients with COVID-19 and immunocompetent hosts. This fungal infection is mainly caused by the opportunistic human pathogen Cryptococcus neoformans. Brain or central nervous system (CNS) dissemination is the deadliest process for th...

Efficacy of Osimertinib in Lung Squamous Cell Carcinoma Patients with EGFR Gene Mutatio...
https://doi.org/10.3390/curroncol29050285
Current Oncology (Toronto, Ont.); Rekowska A, Rola P et. al.

May 28th, 2022 - Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and the leading cause of cancer-related mortality worldwide. It is responsible for 80-85% of lung cancer cases. NSCLC can be divided into several groups, led by adenocarcinoma (ADC)-40-50% and squamous cell carcinoma (SCC)-20-30%. The development of new molecular therapies targeting particular abnormalities such as mutati...

The Role of Microorganisms in Appendiceal Pseudomyxoma Peritonei: A Review.
https://doi.org/10.3390/curroncol29050289
Current Oncology (Toronto, Ont.); Khamzina Y, King MC et. al.

May 28th, 2022 - Pseudomyxoma peritonei (PMP) is a rare clinical syndrome. It originates from neoplasms of the appendix and leads to the formation of peritoneal implants and the accumulation of mucinous ascites. PMP represents a spectrum of low to high-grade disease. Despite aggressive management, many PMP patients recur, leading to debilitating symptoms and few treatment options. Therefore, scientists have con...

Fueling the fire in the gut.
https://doi.org/10.1084/jem.20220723
The Journal of Experimental Medicine; Lin CH, Lu LF

May 28th, 2022 - Gut dysbiosis has long been associated with the development of Crohn's disease and other gastrointestinal disorders. Otake-Kasamoto et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20211291) report that dysbiotic microbiota-derived bioactive lipids, lysophosphatidylserines, can promote pathological Th1 cell responses through inducing metabolic reprogramming and epigenetic changes.

Identification of a Germline Pyrin Variant in a Metastatic Melanoma Patient With Multip...
https://doi.org/10.1097/CJI.0000000000000425
Journal of Immunotherapy (Hagerstown, Md. : 1997); Oswalt CJ, Al-Rohil RN et. al.

May 28th, 2022 - The mechanisms underlying tumor immunosurveillance and their association with the immune-related adverse events (irAEs) associated with checkpoint inhibitor immunotherapies remain poorly understood. We describe a metastatic melanoma patient exhibiting multiple episodes of spontaneous disease regression followed by the development of several irAEs during the course of anti-programmed cell death ...

Inpatient Care Utilization and Epidemiology of Hirschsprung Disease: Analysis of the Na...
https://doi.org/10.1097/MPG.0000000000003449
Journal of Pediatric Gastroenterology and Nutrition; Dharmaraj R, Reno J et. al.

May 28th, 2022 - Hirschsprung disease (HD) is associated with significant morbidities including long-term bowel dysfunction. The aim of this study was to update national and regional trends in the inpatient care utilization and epidemiology of HD in the United States between 2009 and 2014 using the National Inpatient Sample (NIS) database. We identified all pediatric admissions with a diagnosis of HD within the...

Portal pressure is of significant prognostic value in primary biliary cholangitis.
https://doi.org/10.1111/liv.15289
Liver International : Official Journal of the Internation... Warnes TW, Roberts SA et. al.

May 28th, 2022 - In other forms of chronic liver disease, measurement of portal pressure is of prognostic value, but this has not yet been established in primary biliary cholangitis (PBC). The aim of the study is to determine the prognostic value of hepatic venous pressure gradient (HVPG) in relation to liver-related survival outcomes, as well as to the development of hepatic decompensation, esophageal varices ...

Incidence and survival in laryngeal and lung cancers in Finland and Sweden through a ha...
https://doi.org/10.1371/journal.pone.0268922
PloS One; Koskinen A, Hemminki O et. al.

May 28th, 2022 - Global survival studies have shown favorable development in most cancers but few studies have considered laryngeal cancer, particularly over extended periods or in populations for which medical care is essentially free of charge. We analyzed laryngeal and lung cancer incidence and survival in Finland (FI) and Sweden (SE) over a 50-year period (1970-2019) using data and statistical tools from th...