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About 59,323 results

Delta reinfection risk low among unvaccinated children
https://www.nature.com/articles/d41586-022-01763-3
Nature Ledford H.

Jun 29th, 2022 - Children and adolescents who had not been vaccinated against COVID-19 mounted a long-lasting immune response to infection with the Delta variant of the coronavirus SARS-CoV-2, according to a large study of Israeli health records1. The study, which has been published as a preprint on medRxiv, has not yet been peer reviewed.

COVID and smell loss: answers begin to emerge
https://www.nature.com/articles/d41586-022-01589-z
Nature Marshall M.

Jun 9th, 2022 - Researchers are finally making headway in understanding how the SARS-CoV-2 coronavirus causes loss of smell. And a multitude of potential treatments to tackle the condition are undergoing clinical trials, including steroids and blood plasma.

Ambient air pollution and COVID-19 risk: Evidence from 35 observational studies
https://www.sciencedirect.com/science/article/pii/S0013935121013608?via=ihub
Environmental Research; Zang ST, .

Mar 30th, 2022 - Coronavirus disease 2019 (COVID-19) is induced by a previously undiscovered coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Lu et al., 2020). Since SARS-CoV-2 was first discovered in December 2019, as of April 25, 2021, more than four million fatalities have been attributed to COVID-19, accounting for approximately 2% of the infected cases (>214 million)...

Coronavirus (COVID-19) Update: FDA Recommends Inclusion of Omicron BA.4/5 Component for COVID-19 Vaccine Booster Doses | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-recommends-inclusion-omicron-ba45-component-covid-19-vaccine-booster

Jun 30th, 2022 - For Immediate Release: June 30, 2022 Statement From: Peter Marks, M.D., PhD. Director - Center for Biologics Evaluation and Research (CBER) On Tuesday, the U.S. Food and Drug Administration’s independent experts on the Vaccines and Related Biological Products Advisory Committee met to publicly discuss whether a change to the current vaccine strain composition of COVID-19 vaccines for booster do...

Data-Driven Commentary on SARS-CoV-2 Infection, Vaccination, and Fertility.
https://doi.org/10.1093/aje/kwac073
American Journal of Epidemiology; Klipstein S, Dionne JA et. al.

Jun 30th, 2022 - A recent study by Wesselink et al. (Am J Epidemiol. 2022;191(XX):XXXX-XXXX) adds to the growing body of research finding that vaccination for coronavirus disease 2019 (COVID-19) is safe for individuals either seeking pregnancy or who are pregnant. The study's authors found no effect of COVID-19 vaccination on fecundity in a population of individuals with no known infertility who were attempting...

SARS-CoV-2 and Guillain-Barré Syndrome: Lessons from Viral Infections.
https://doi.org/10.1089/vim.2021.0187
Viral Immunology; Meidaninikjeh S, Sabouni N et. al.

Jun 30th, 2022 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. COVID-19 has a broad clinical spectrum from asymptomatic patients to multiorgan dysfunction and septic shock. Most of the common symptoms of COVID-19 are classified as respiratory disorders, but some reports show neurological involvements. During the COVID-19 pandemic, a case series of neurolo...

Trends in Telehealth Antibiotic Prescribing for Children Through the COVID-19 Pandemic.
https://doi.org/10.1542/peds.2022-056209
Pediatrics Payvandi L, Correa ET et. al.

Jun 30th, 2022 - Telehealth visits increased significantly during the coronavirus disease 2019 (COVID-19) pandemic without consensus on the appropriate scope of telehealth antibiotic prescribing within pediatric primary care. We describe telehealth antibiotic prescribing patterns within our statewide pediatric primary care network during the COVID-19 pandemic. In a retrospective observational study of a large s...

BNT162b2 Vaccine Effectiveness against Omicron in Children 5 to 11 Years of Age.
https://doi.org/10.1056/NEJMoa2205011
The New England Journal of Medicine; Cohen-Stavi CJ, Magen O et. al.

Jun 30th, 2022 - Limited evidence is available on the real-world effectiveness of the BNT162b2 vaccine against coronavirus disease 2019 (Covid-19) and specifically against infection with the omicron variant among children 5 to 11 years of age. Using data from the largest health care organization in Israel, we identified a cohort of children 5 to 11 years of age who were vaccinated on or after November 23, 2021,...

Dementia prevalence, a contextual factor associated with SARS-CoV-2 in veterans affairs...
https://doi.org/10.1111/jgs.17945
Journal of the American Geriatrics Society; Bayer TA, DeVone F et. al.

Jun 30th, 2022 - Alzheimer's disease and related dementias (ADRD) impact the diagnosis and infection control of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in nursing homes (NH) by influencing the behavior of residents and their caregivers. Health system data show an association between ADRD and SARS-CoV-2. Whether this association is present in NH populations remains unknown. How increased SAR...

Early spontaneous breathing for acute respiratory distress syndrome in individuals with...
https://doi.org/10.1002/14651858.CD015077
The Cochrane Database of Systematic Reviews; Hohmann F, Wedekind L et. al.

Jun 30th, 2022 - Acute respiratory distress syndrome (ARDS) represents the most severe course of COVID-19 (caused by the SARS-CoV-2 virus), usually resulting in a prolonged stay in an intensive care unit (ICU) and high mortality rates. Despite the fact that most affected individuals need invasive mechanical ventilation (IMV), evidence on specific ventilation strategies for ARDS caused by COVID-19 is scarce. Spo...

South Korea Approves First Domestically Developed COVID Vaccine
https://www.medscape.com/viewarticle/976355

Jun 30th, 2022 - SEOUL (Reuters) - South Korea approved its first domestically developed COVID-19 vaccine, manufactured by SK bioscience Co Ltd, for general public use following positive clinical data, authorities said on Wednesday. The SKYCovione vaccine was authorised for a two-dose regimen on people aged 18 or older, with shots given four weeks apart, according to the Ministry of Food and Drug Safety. In a p...

Severe COVID-19 in Chronic Liver Disease Linked With Cholestasis and Secondary Sclerosing Cholangitis
https://www.medscape.com/viewarticle/976382

Jun 30th, 2022 - NEW YORK (Reuters Health) - Severe COVID-19 increases the risk for cholestasis and secondary sclerosing cholangitis (SSC) in patients with chronic liver disease (CLD), researchers say. Among 65 patients with preexisting CLD who were hospitalized for COVID-19, 23% developed cholestatic liver failure (cholestasis plus bilirubin at least 6mg/dL) and 15.4% developed SSC on the basis of cross-sectio...

Vaccines for New COVID Variants Might Come Too Late
https://www.medscape.com/viewarticle/976441

Jun 30th, 2022 - Not surprisingly for an RNA virus, SARS-CoV-2 is proving its propensity for mutation. In swabs from infected patients, the proportion of the Omicron subvariant BA.4 is 2.1% (calendar week 21) compared with 1.2% in the previous week. In the same period of time, the frequency of subvariant BA.5 jumped up to 10.0%compared with 5.0% in the previous week. This dynamic leads to a crucial question: Wh...

Pfizer Plans a Vaccine to Target All Coronaviruses
https://www.medscape.com/viewarticle/976462

Jun 30th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Ask the sibling of any celebrity and they'll tell you they don't get anywhere near the same attention. The same is true for coronaviruses – the one that causes COVID-19 has been in the spotlight for more than 2 years now, while the others at the moment circulate in relative obscurity. With the k...

Helminth antigens differentially modulate the activation of CD4+ and CD8+ T lymphocytes...
https://doi.org/10.1186/s12916-022-02441-x 10.1126/science.abd3902 10.1016/j.immuni.2018.02.011 10.1016/S0140-6736(20)30798-4 10.1016/j.jaci.2016.07.007 10.1179/136485910X12786389891407 10.1002/eji.200838193 10.3389/fimmu.2022.790895 10.1080/07391102.2020.1803139 10.1371/journal.pone.0253894 10.1097/BOR.0000000000000822 10.1371/journal.pntd.0001611 10.1371/journal.pntd.0007436 10.1371/journal.pntd.0006184 10.1371/journal.pntd.0007623 10.1111/2049-632X.12080 10.1093/infdis/jiz594 10.1371/journal.pntd.0006613 10.1038/s12276-020-0435-8 10.1038/nri.2015.10 10.1016/j.celrep.2021.109320 10.1016/j.immuni.2019.10.009 10.1182/blood-2006-11-056168 10.1002/eji.201646837 10.1016/0167-5699(94)90193-7 10.1007/s10875-021-01142-z 10.1016/j.cell.2020.09.038 10.1016/j.cell.2021.01.007 10.1186/s13071-019-3525-5 10.1179/000349802125001735 10.1371/journal.pntd.0009646 10.1371/journal.pntd.0005777 10.1371/journal.ppat.1004616 10.1186/1756-3305-6-203 10.4049/jimmunol.0902373 10.1016/j.celrep.2021.109696 10.1073/pnas.1808849116 10.1182/blood-2006-10-053256 10.1186/1756-3305-4-186 10.1016/j.jaci.2006.09.030 10.4049/jimmunol.2100565 10.1084/jem.174.5.1209 10.1128/IAI.05191-11 10.1002/JLB.3A0318-111RR 10.3389/fimmu.2021.615089 10.1016/j.pt.2020.10.002 10.1021/acsptsci.0c00141 10.1016/j.tmaid.2021.102087 10.1371/journal.pntd.0006241
BMC Medicine; Adjobimey T, Meyer J et. al.

Jun 29th, 2022 - The coronavirus disease 2019 (COVID-19) is a respiratory disease caused by SARS-CoV-2, a recently discovered strain of coronavirus. The virus has spread rapidly, causing millions of death worldwide. Contrary to the predictions, prevalence and mortality due to COVID-19 have remained moderate on the African continent. Several factors, including age, genetics, vaccines, and co-infections, might im...

Immune Responses after a Third Dose of mRNA Vaccine Differ in Virus-Naive versus SARS-C...
https://doi.org/10.2215/CJN.00830122
Clinical Journal of the American Society of Nephrology : ... Attias P, Azzaoui I et. al.

Jun 29th, 2022 - After two doses of mRNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), patients on dialysis show a defective humoral response, but a third dose could increase anti-SARS-CoV-2 spike IgG titers. Responses could be different in virus-naive and SARS-CoV-2-recovered patients on dialysis. However, characterization of memory B cell response after three doses is lacking. ...

SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoa...
https://doi.org/10.1038/s41467-022-31193-8 10.1016/j.cell.2014.02.039 10.1002/biot.201100155 10.1073/pnas.1704872114 10.1016/j.cell.2016.09.013 10.1021/acssynbio.8b00448 10.1073/pnas.2009707117 10.1073/pnas.1401291111 10.1038/srep19234 10.1039/D0SC01878C 10.1038/s41467-019-09678-w 10.1073/pnas.1909653116 10.1038/ncomms3211 10.1021/acsmacrolett.8b00668 10.1039/C7CC04507G 10.1021/jacs.1c03198 10.1038/372379a0 10.1038/nbt725 10.4161/19420862.2014.985993 10.1126/science.aav7897 10.1093/database/baz024 10.1126/science.abf6840 10.1038/s41564-020-0771-4 10.1016/j.cell.2021.09.015 10.1002/0471140864.ps0601s80 10.1002/anie.201707623 10.1016/j.chom.2020.11.004 10.1016/j.coi.2020.03.013 10.3389/fimmu.2018.01432 10.1002/anie.202009663 10.1126/science.abb9983 10.1016/j.vaccine.2016.10.079 10.1016/j.memsci.2007.02.045 10.1038/s41586-020-2852-1 10.1371/journal.ppat.1009352 10.1126/science.abb7269 10.1038/s41594-020-0480-y 10.1016/j.cell.2018.12.028 10.1038/s41467-020-20654-7 10.1093/protein/10.8.975 10.3109/07853890.2011.579150 10.1073/pnas.0402222101 10.1016/j.chroma.2013.07.015 10.1016/j.chroma.2014.08.046 10.18388/abp.1999_4131 10.1016/j.pep.2004.10.017 10.1016/j.ijpara.2016.12.001 10.1016/j.chembiol.2021.07.005 10.1038/s42003-019-0457-8 10.1007/s00449-020-02382-w 10.1038/s41467-020-20251-8 10.3390/vaccines9060651 10.1016/j.celrep.2021.109760 10.1038/s41586-021-03807-6 10.1007/s10969-010-9090-y 10.1073/pnas.1115485109 10.1158/0008-5472.CAN-12-2956 10.1038/s42003-021-02487-2 10.7150/thno.65563 10.1038/nprot.2009.3 10.1073/pnas.1510199112 10.1016/j.jmb.2013.10.021 10.1002/prot.22927 10.1007/s10930-019-09838-3 10.1021/acsnano.8b02805 10.1038/s41586-020-2180-5 10.1093/molbev/msab120 10.1093/nar/gkz268
Nature Communications; Vester SK, Rahikainen R et. al.

Jun 29th, 2022 - Proteins can be empowered via SpyTag for anchoring and nanoassembly, through covalent bonding to SpyCatcher partners. Here we generate a switchable version of SpyCatcher, allowing gentle purification of SpyTagged proteins. We introduce numerous histidines adjacent to SpyTag's binding site, giving moderate pH-dependent release. After phage-based selection, our final SpySwitch allows purification...

COVID-19 in Fabry disease: a reference center prospective study.
https://doi.org/10.1186/s13023-022-02386-7 10.1038/s41581-020-00357-4 10.1016/j.ymgme.2017.07.002 10.1111/j.1365-2362.2004.01309.x 10.1002/jimd.12167 10.1016/j.ymgme.2021.02.001 10.1681/ASN.2016090964 10.2147/TACG.S146022 10.1016/j.ymgme.2018.06.004 10.1002/ehf2.12647 10.1093/ckj/sfaa227 10.1016/S2213-2600(21)00031-X 10.1097/GIM.0b013e3181bb05bb 10.1164/ajrccm.155.3.9116979 10.1136/bmjresp-2018-000277 10.1002/jobm.202000537 10.1016/j.ymgme.2020.04.002 10.1016/j.ymgme.2020.07.008 10.1136/postgradmedj-2020-138577 10.1371/journal.pone.0180437 10.1016/j.mehy.2020.110282 10.7883/yoken.JJID.2020.729 10.1016/j.ymgmr.2021.100802 10.1038/s41577-019-0244-2 10.1681/ASN.2021040490 10.1111/ajt.16702 10.1056/NEJMc2111462 10.1016/S0140-6736(21)02096-1
Orphanet Journal of Rare Diseases; Bothou C, Saleh L et. al.

Jun 29th, 2022 - During the coronavirus disease-19 (COVID-19) pandemic, vulnerable populations must be identified to prevent increased mortality. Fabry disease (FD) is a rare X-linked lysosomal storage disorder leading to chronic kidney disease (CKD), cardiomyopathy, pneumonopathy and premature strokes. Little is known whether SARS-CoV-2 infection bears a particular risk for FD patients. During pandemic (02.202...

Chest CT Findings in Hospitalized Patients with SARS-CoV-2: Delta versus Omicron Variants.
https://doi.org/10.1148/radiol.220676
Radiology Yoon SH, Lee JH et. al.

Jun 29th, 2022 - Background CT manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may differ among variants. Purpose To compare the chest CT findings of SARS-CoV-2 between the Delta and Omicron variants. Materials and Methods This retrospective study collected consecutive baseline chest CT images of hospitalized patients with SARS-CoV-2 from a secondary referral hospital when the Del...

Clinical characteristics and comorbidities of COVID-19 in unvaccinated patients with Do...
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Human Genetics; Boschiero MN, Palamim CVC et. al.

Jun 29th, 2022 - Patients with Down syndrome (DS) are more affected by the Coronavirus Disease (COVID)-19 pandemic when compared with other populations. Therefore, the primary aim of our study was to report the death (case fatality rate) from SARS-CoV-2 infection in Brazilian hospitalized patients with DS from 03 January 2020 to 04 April 2021. The secondary objectives were (i) to compare the features of patient...