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About 43,368 results

SARS-CoV-2 vaccine protection and deaths among US veterans during 2021
https://www.science.org/doi/10.1126/science.abm0620
Science Cohn BA, .

Nov 4th, 2021 - The messenger RNA vaccines BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna) and the viral vector vaccine JNJ-78436735 (Janssen) have effectively prevented clinically significant disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since their rollout in the U.S. in late 2020 (1, 2).

Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report
https://www.medrxiv.org/content/10.1101/2021.10.10.21264827v1.full.pdf
Medrxiv Atmar RL, .

Oct 13th, 2021 - Background: While Coronavirus disease 2019 (Covid-19) vaccines are highly effective, breakthrough infections are occurring. Booster vaccinations have recently received emergency use authorization (EUA) for certain populations but are restricted to homologous mRNA vaccines. We evaluated homologous and heterologous booster vaccination in persons who had received an EUA Covid-19 vaccine regimen.

Retrospective evaluation of an observational cohort by the Central and Eastern Europe N...
https://doi.org/10.1111/hiv.13214
HIV Medicine; Lakatos B, Kowalska J et. al.

Dec 4th, 2021 - The aim of this international multicentre study was to review potential drug-drug interactions (DDIs) for real-life coadministration of combination antiretroviral therapy (cART) and coronavirus disease 2019 (COVID-19)-specific medications. The Euroguidelines in Central and Eastern Europe Network Group initiated a retrospective, observational cohort study of HIV-positive patients diagnosed with ...

Probable Transmission of SARS-CoV-2 Omicron Variant in Quarantine Hotel, Hong Kong, Chi...
https://doi.org/10.3201/eid2802.212422
Emerging Infectious Diseases; Gu H, Krishnan P et. al.

Dec 4th, 2021 - We report detection of severe acute respiratory syndrome coronavirus 2 Omicron variant (B.1.1.529) in an asymptomatic, fully vaccinated traveler in a quarantine hotel in Hong Kong, China. The Omicron variant was also detected in a fully vaccinated traveler staying in a room across the corridor from the index patient, suggesting transmission despite strict quarantine precautions.

An upper bound on one-to-one exposure to infectious human respiratory particles.
https://doi.org/10.1073/pnas.2110117118
Proceedings of the National Academy of Sciences of the Un... Bagheri G, Thiede B et. al.

Dec 4th, 2021 - There is ample evidence that masking and social distancing are effective in reducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. However, due to the complexity of airborne disease transmission, it is difficult to quantify their effectiveness, especially in the case of one-to-one exposure. Here, we introduce the concept of an upper bound for one-to-one exposure to ...

Characteristics of Children Diagnosed With SARS-CoV-2 in the Ambulatory Setting.
https://doi.org/10.1177/00099228211064378
Clinical Pediatrics; Guo N, Crim K et. al.

Dec 4th, 2021 - The objective of this study was to characterize the clinical presentation and outcomes of children and adolescents testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the ambulatory setting. We found that about 8% of children tested positive for SARS-CoV-2, with the large majority being symptomatic (80%). The average age of our population was 12.5 years, and fem...

Spectrum of SARS-CoV-2-Related Clinical Syndromes in Children: A Year in the Life.
https://doi.org/10.1177/00099228211064655
Clinical Pediatrics; Khan M, Dang L et. al.

Dec 4th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a wide pediatric clinical spectrum. Initial reports suggested that children had milder symptoms compared with adults; then diagnosis of multisystem inflammatory syndrome in children (MIS-C) emerged. We performed a retrospective cohort study of hospitalized patients at a children's hospital over 1 year. Our objectives were to study...

The persistent challenges faced by vascular surgery services during the UK coronavirus ...
https://doi.org/10.1308/rcsann.2021.0202
Annals of the Royal College of Surgeons of England; Nandhra S, Benson RA et. al.

Dec 4th, 2021 - The coronavirus (COVID-19) pandemic continues to affect the NHS. The Vascular and Endovascular Research Network (VERN) COvid Vascular sERvice (COVER) study has prospectively shown the significant global impact of the COVID-19 pandemic on vascular surgery. The aim of this study is to investigate the way in which this second wave has affected surgeons' ability to treat patients with urgent vascul...

Use of Cardiopulmonary Stress Testing for Patients With Unexplained Dyspnea Post-Corona...
https://doi.org/10.1016/j.jchf.2021.10.002
JACC. Heart Failure; Mancini DM, Brunjes DL et. al.

Dec 4th, 2021 - The authors used cardiopulmonary exercise testing (CPET) to define unexplained dyspnea in patients with post-acute sequelae of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection (PASC). We assessed participants for criteria to diagnose myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Approximately 20% of patients who recover from coronavirus disease (COVID) remai...

Observational study on the benefit of a nutritional supplement, supporting immune funct...
https://doi.org/10.1016/j.clnesp.2021.08.031
Clinical Nutrition ESPEN; Rossato MS, Brilli E et. al.

Dec 4th, 2021 - Recent studies have verified that the SARS-CoV-2 infection (from December 2019 has affected 123 million people throughout the world and more than 3 million people in Italy), can have medium-term and long-term effects, collectively referred to as "post-Covid syndrome" or "long-Covid" characterized by chronic fatigue, followed by muscle weakness, dyspnea and headache. Chronic fatigue or chronic t...

Insufficient response to mRNA SARS-CoV-2 vaccine and high incidence of severe COVID-19 ...
https://doi.org/10.1111/ajt.16902
American Journal of Transplantation : Official Journal Of... Reischig T, Kacer M et. al.

Dec 4th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination may fail to sufficiently protect transplant recipients against coronavirus disease 2019 (COVID-19). We retrospectively evaluated COVID-19 in kidney transplant recipients (n=226) after BNT162b2 mRNA vaccine administration. The control group consisted of unvaccinated patients (n=194) during the previous pandemic wave. W...

Coronavirus Disease 2019 (COVID-19) Antibody Plasma Research Study in Hospitalized Patients
https://clinicaltrials.gov/ct2/show/NCT04524507

Dec 3rd, 2021 - This randomized, double-blinded, phase 2 trial will assess the efficacy and safety of anti-SARS-CoV-2 convalescent plasma in hospitalized patients with less than 8 days of symptoms. Eligible participants will receive institutional-guided standard-of-care (SOC) and ABO-compatible convalescent COVID-19 plasma (CCP). The CCP units will be tested for the presence of anti-SARS-CoV-2 antibodies and p...

Case Report: Severe SARS-CoV-2 Infection with Remdesivir in a Patient with ESRD.
https://doi.org/10.2174/1871526521666211201112410
Infectious Disorders Drug Targets; Patel RH, Pella PM et. al.

Dec 3rd, 2021 - The novel coronavirus disease 2019 (COVID-19) has led to a global pandemic since its emergence from Wuhan, China, in December of 2019. As research continues to evolve, there is a paucity of reports describing the management and treatment of COVID-19 in patients with acute kidney failure and end-stage renal disease (ESRD). These patients have increased susceptibility to developing severe clinica...

Continuously Active Disinfectant Inactivates SARS-CoV-2 and Human Coronavirus 229E Two ...
https://doi.org/10.1017/ice.2021.481
Infection Control and Hospital Epidemiology; Rutala WA, Ikner LA et. al.

Dec 3rd, 2021 - The surface environment in COVID-19 patient's rooms may be persistently contaminated despite disinfection. A continuously active disinfectant demonstrated excellent sustained antiviral activity following a 48-hour period of wear and abrasion exposures with reinoculations. Reductions of >4-log10 were achieved within a 1-minute contact time for SARS-CoV-2 and the human coronavirus, 229E.

Impact of the SARS-CoV-2 Pandemic on Primary Percutaneous Coronary Intervention for Pat...
https://doi.org/10.1536/ihj.21-308
International Heart Journal; Matsubara Y, Izumikawa T et. al.

Dec 3rd, 2021 - During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, patients with ST-elevation myocardial infarction (STEMI) should be treated as possibly infected individuals. Therefore, more time is considered necessary to conduct primary percutaneous coronary intervention (PCI). In this study, we sought to evaluate the impact of the SARS-CoV-2 pandemic on primary PCI for STEMI....

Monoclonal gammopathy of undetermined significance and COVID-19: a population-based coh...
https://doi.org/10.1038/s41408-021-00580-7 10.1016/S0140-6736(20)30183-5 10.1056/nejmoa2002032 10.1016/j.chest.2020.04.010 10.1158/2643-3230.bcd-20-0102 10.1182/blood.2020008150 10.1182/blood-2008-12-194241 10.1182/blood-2008-12-195008 10.1016/s1470-2045(14)70442-5 10.1056/nejmoa054494 10.1016/s0140-6736(10)60482-5 10.1111/j.1600-0609.1998.tb01075.x 10.3324/haematol.2011.054015 10.1182/blood-2009-11-252072 10.1182/blood-2012-07-445304 10.1016/j.bcmd.2020.102481 10.4065/84.8.685 10.1056/nejmoa2006100 10.1038/s41408-021-00480-w
Blood Cancer Journal; Rognvaldsson S, Eythorsson E et. al.

Dec 3rd, 2021 - Multiple myeloma (MM) patients have increased risk of severe coronavirus disease 2019 (COVID-19) when infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Monoclonal gammopathy of undetermined significance (MGUS), the precursor of MM has been associated with immune dysfunction which may lead to severe COVID-19. No systematic data have been published on COVID-19 in individua...

Alamandine: Potential Protective Effects in SARS-CoV-2 Patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592730
Journal of the Renin-angiotensin-aldosterone System : JRAAS; Soltani Hekmat A, Javanmardi K

Dec 3rd, 2021 - Coronavirus disease 2019 (COVID-19) can occur due to contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has no confined treatment and, consequently, has high hospitalization and mortality rates. Moreover, people who contract COVID-19 present systemic inflammatory spillover. It is now known that COVID-19 pathogenesis is linked to the renin-angiotensin system (RAS)...

Advances in laboratory detection methods and technology application of SARS-CoV-2.
https://doi.org/10.1002/jmv.27494
Journal of Medical Virology; Zhang X, Meng H et. al.

Dec 3rd, 2021 - At present, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is raging worldwide, and the COVID-19 outbreak caused by SARS-CoV-2 seriously threatens the life and health of all humankind. There is no specific medicine for novel coronavirus yet. So, laboratory diagnoses of novel coronavirus as soon as possible and isolation of the source of infection play a vital role in preventing an...

Infection with SARS-CoV-2 among children with asthma: evidence from Global Asthma Network.
https://doi.org/10.1111/pai.13709
Pediatric Allergy and Immunology : Official Publication O... Chiang CY, Ellwood P et. al.

Dec 3rd, 2021 - Clinical presentations of coronavirus disease 2019 (COVID-19) among children with asthma have rarely been investigated. This study aimed to assess clinical manifestations and outcome of COVID-19 among children with asthma, and whether the use of asthma medications was associated with outcomes of interest. The Global Asthma Network (GAN) conducted a global survey among GAN centres. Data collecti...

Drug Repurposing strategies and key challenges for Covid-19 management.
https://doi.org/10.1080/1061186X.2021.2013852
Journal of Drug Targeting; Mule S, Singh A et. al.

Dec 3rd, 2021 - Covid- 19 is a clinical outcome of viral infection emerged due to strain of beta coronavirus which attacks the type-2 pneumocytes in alveoli via ACE2 receptors. There is no satisfactory drug therapeutic is developed against "SARS-CoV2", highlighting needs of an immediate necessity to give a thorough insight on using chemotherapeutic repurposing plan for the develop COVID-19 infected patients tr...