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About 59,350 results

Delta reinfection risk low among unvaccinated children
https://www.nature.com/articles/d41586-022-01763-3
Nature Ledford H.

Jun 29th, 2022 - Children and adolescents who had not been vaccinated against COVID-19 mounted a long-lasting immune response to infection with the Delta variant of the coronavirus SARS-CoV-2, according to a large study of Israeli health records1. The study, which has been published as a preprint on medRxiv, has not yet been peer reviewed.

COVID and smell loss: answers begin to emerge
https://www.nature.com/articles/d41586-022-01589-z
Nature Marshall M.

Jun 9th, 2022 - Researchers are finally making headway in understanding how the SARS-CoV-2 coronavirus causes loss of smell. And a multitude of potential treatments to tackle the condition are undergoing clinical trials, including steroids and blood plasma.

Ambient air pollution and COVID-19 risk: Evidence from 35 observational studies
https://www.sciencedirect.com/science/article/pii/S0013935121013608?via=ihub
Environmental Research; Zang ST, .

Mar 30th, 2022 - Coronavirus disease 2019 (COVID-19) is induced by a previously undiscovered coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Lu et al., 2020). Since SARS-CoV-2 was first discovered in December 2019, as of April 25, 2021, more than four million fatalities have been attributed to COVID-19, accounting for approximately 2% of the infected cases (>214 million)...

Genomic surveillance of SARS-CoV-2 in patients presenting neurological manifestations.
https://doi.org/10.1371/journal.pone.0270024
PloS One; Vicco A, Caccuri F et. al.

Jul 1st, 2022 - During the first wave of infections, neurological symptoms in Coronavirus Disease 2019 (COVID-19) patients raised particular concern, suggesting that, in a subset of patients, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could invade and damage cells of the central nervous system (CNS). Indeed, up to date several in vitro and in vivo studies have shown the ability of SARS-Co...

Projecting the SARS-CoV-2 transition from pandemicity to endemicity: Epidemiological an...
https://doi.org/10.1371/journal.ppat.1010591
PLoS Pathogens; Cohen LE, Spiro DJ et. al.

Jul 1st, 2022 - In this review, we discuss the epidemiological dynamics of different viral infections to project how the transition from a pandemic to endemic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) might take shape. Drawing from theories of disease invasion and transmission dynamics, waning immunity in the face of viral evolution and antigenic drift, and empirical data from influenza, den...

Identification of repurposing therapeutics toward SARS-CoV-2 main protease by virtual s...
https://doi.org/10.1371/journal.pone.0269563
PloS One; Sanachai K, Somboon T et. al.

Jul 1st, 2022 - SARS-CoV-2 causes the current global pandemic coronavirus disease 2019. Widely-available effective drugs could be a critical factor in halting the pandemic. The main protease (3CLpro) plays a vital role in viral replication; therefore, it is of great interest to find inhibitors for this enzyme. We applied the combination of virtual screening based on molecular docking derived from the crystal s...

The nervous system during COVID-19: Caught in the crossfire.
https://doi.org/10.1111/imr.13114
Immunological Reviews; Natale NR, Lukens JR et. al.

Jul 1st, 2022 - SARS-CoV-2, the virus that causes coronavirus disease (COVID)-19, has become a persistent global health threat. Individuals who are symptomatic for COVID-19 frequently exhibit respiratory illness, which is often accompanied by neurological symptoms of anosmia and fatigue. Mounting clinical data also indicate that many COVID-19 patients display long-term neurological disorders postinfection such...

SARS-CoV-2 Antibody Longitudinal Profile of Immune Globulin Preparations.
https://doi.org/10.1093/milmed/usac192
Military Medicine; Park HJ, Alcover KC et. al.

Jul 1st, 2022 - Intravenous immunoglobulin (IVIG) preparations, used for the treatment of antibody deficiencies, provide a glimpse of the general population's antibody profile as each preparation is generated from a pool of thousands of donors. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the coronavirus disease 2019 (Covid-19) pandemic, and a vaccine for the pr...

Warm Cupping of the Posterior Thorax in Combination with Standard Conventional Therapy ...
https://doi.org/10.51507/j.jams.2022.15.3.194
Journal of Acupuncture and Meridian Studies; Karimi M, Kazemi AH et. al.

Jul 1st, 2022 - Acute respiratory distress syndrome (ARDS) is commonly found in critically ill patients with coronavirus disease 2019 (COVID-19). As a non-pharmacological treatment of complementary and alternative medicine (CAM), cupping has been clinically used for respiratory symptoms. We sequentially identified a series of patients with COVID-19 with ARDS who were admitted to the intensive care unit (ICU). ...

Coronavirus (COVID-19) Update: FDA Recommends Inclusion of Omicron BA.4/5 Component for COVID-19 Vaccine Booster Doses | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-recommends-inclusion-omicron-ba45-component-covid-19-vaccine-booster

Jun 30th, 2022 - For Immediate Release: June 30, 2022 Statement From: Peter Marks, M.D., PhD. Director - Center for Biologics Evaluation and Research (CBER) On Tuesday, the U.S. Food and Drug Administration’s independent experts on the Vaccines and Related Biological Products Advisory Committee met to publicly discuss whether a change to the current vaccine strain composition of COVID-19 vaccines for booster do...

South Korea Approves First Domestically Developed COVID Vaccine
https://www.medscape.com/viewarticle/976355

Jun 30th, 2022 - SEOUL (Reuters) - South Korea approved its first domestically developed COVID-19 vaccine, manufactured by SK bioscience Co Ltd, for general public use following positive clinical data, authorities said on Wednesday. The SKYCovione vaccine was authorised for a two-dose regimen on people aged 18 or older, with shots given four weeks apart, according to the Ministry of Food and Drug Safety. In a p...

Vaccines for New COVID Variants Might Come Too Late
https://www.medscape.com/viewarticle/976441

Jun 30th, 2022 - Not surprisingly for an RNA virus, SARS-CoV-2 is proving its propensity for mutation. In swabs from infected patients, the proportion of the Omicron subvariant BA.4 is 2.1% (calendar week 21) compared with 1.2% in the previous week. In the same period of time, the frequency of subvariant BA.5 jumped up to 10.0%compared with 5.0% in the previous week. This dynamic leads to a crucial question: Wh...

Severe COVID-19 in Chronic Liver Disease Linked With Cholestasis and Secondary Sclerosing Cholangitis
https://www.medscape.com/viewarticle/976382

Jun 30th, 2022 - NEW YORK (Reuters Health) - Severe COVID-19 increases the risk for cholestasis and secondary sclerosing cholangitis (SSC) in patients with chronic liver disease (CLD), researchers say. Among 65 patients with preexisting CLD who were hospitalized for COVID-19, 23% developed cholestatic liver failure (cholestasis plus bilirubin at least 6mg/dL) and 15.4% developed SSC on the basis of cross-sectio...

Pfizer Plans a Vaccine to Target All Coronaviruses
https://www.medscape.com/viewarticle/976462

Jun 30th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Ask the sibling of any celebrity and they'll tell you they don't get anywhere near the same attention. The same is true for coronaviruses – the one that causes COVID-19 has been in the spotlight for more than 2 years now, while the others at the moment circulate in relative obscurity. With the k...

A broad and potent neutralization epitope in SARS-related coronaviruses.
https://doi.org/10.1073/pnas.2205784119
Proceedings of the National Academy of Sciences of the Un... Yuan M, Zhu X et. al.

Jun 30th, 2022 - Many neutralizing antibodies (nAbs) elicited to ancestral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through natural infection and vaccination have reduced effectiveness to SARS-CoV-2 variants. Here, we show that therapeutic antibody ADG20 is able to neutralize SARS-CoV-2 variants of concern (VOCs) including Omicron (B.1.1.529) as well as other SARS-related coronaviruses. We d...

Epidemiological and virological surveillance of influenza viruses in China during 2020-...
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Infectious Diseases of Poverty; Huang WJ, Cheng YH et. al.

Jun 30th, 2022 - During the coronavirus disease 2019 (COVID-19) pandemic, seasonal influenza activity declined globally and remained below previous seasonal levels, but intensified in China since 2021. Preventive measures to COVID-19 accompanied by different epidemic characteristics of influenza in different regions of the world. To better respond to influenza outbreaks under the COVID-19 pandemic, we analyzed ...

Resumption of active recommendation of the human papillomavirus vaccine in Japan and fu...
https://doi.org/10.1080/21645515.2022.2090777
Human Vaccines & Immunotherapeutics; Ujiie M

Jun 30th, 2022 - Japan's immunization program resumed proactively recommending the use of the human papillomavirus (HPV) vaccine nationwide in April 2022, after suspending this recommendation in June 2013. The promotion of catch-up vaccinations is an urgent issue to reduce the increase in cervical cancer and other cancers caused by low vaccination rates. In addition, the National Immunization Program still has ...

Medications Associated with Lower Mortality in a SARS-CoV-2 Positive Cohort of 26,508 V...
https://doi.org/10.1007/s11606-022-07701-3 10.1001/jama.2020.24865 10.7326/M20-3012 10.1001/jamanetworkopen.2020.22310 10.1001/jamainternmed.2020.3857 10.1001/jama.2020.21465 10.1001/jama.2020.23422 10.1016/j.cmet.2020.06.015 10.1016/j.jinf.2020.07.008 10.1172/JCI139642 10.1001/jamanetworkopen.2020.37053 10.1001/jama.2020.13372 10.1213/ANE.0000000000005292 10.1001/jamanetworkopen.2021.3594 10.1038/s41467-021-21553-1 10.1126/science.abe9403 10.1136/annrheumdis-2020-219517 10.1016/S2213-8587(21)00050-4 10.1016/j.diabres.2020.108183 10.1007/s40618-021-01614-4 10.1016/j.annonc.2020.04.479 10.1016/j.hjc.2020.03.002 10.1016/j.pupt.2021.101989 10.3390/ijerph18168486 10.1186/1478-7954-4-2 10.1080/01621459.1957.10501395 10.1093/biomet/75.4.800 10.1198/016214504000001907 10.3390/ijerph5050394 10.1177/1176935120985132 10.7326/M20-2911 10.1136/bmj.m1966 10.1038/s41586-020-2521-4 10.1682/JRRD.2015.06.0104 10.2337/dc18-S009 10.2337/dc18-S008 10.1016/j.biopha.2016.04.043 10.1055/s-0040-1713152 10.1016/j.diabet.2020.07.006 10.2337/dc20-1205 10.4269/ajtmh.20-0375 10.3389/fendo.2020.600439 10.3389/fendo.2021.587801 10.1016/S2213-2600(21)00222-8 10.1016/j.bbrc.2020.11.095 10.1016/j.toxrep.2020.04.012 10.1080/1547691X.2021.1875085 10.2147/PPA.S74531
Journal of General Internal Medicine; Hunt CM, Efird JT et. al.

Jun 30th, 2022 - Many severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) positive patients take commonly prescribed medications with properties which may affect mortality. Assess if common medications postulated to affect clinical outcomes are associated with mortality in SARS-CoV-2 positive patients in the Veterans Health Administration (VHA). Observational national cohort analysis. Consecutive 26,50...

Trends in Telehealth Antibiotic Prescribing for Children Through the COVID-19 Pandemic.
https://doi.org/10.1542/peds.2022-056209
Pediatrics Payvandi L, Correa ET et. al.

Jun 30th, 2022 - Telehealth visits increased significantly during the coronavirus disease 2019 (COVID-19) pandemic without consensus on the appropriate scope of telehealth antibiotic prescribing within pediatric primary care. We describe telehealth antibiotic prescribing patterns within our statewide pediatric primary care network during the COVID-19 pandemic. In a retrospective observational study of a large s...

Data-Driven Commentary on SARS-CoV-2 Infection, Vaccination, and Fertility.
https://doi.org/10.1093/aje/kwac073
American Journal of Epidemiology; Klipstein S, Dionne JA et. al.

Jun 30th, 2022 - A recent study by Wesselink et al. (Am J Epidemiol. 2022;191(XX):XXXX-XXXX) adds to the growing body of research finding that vaccination for coronavirus disease 2019 (COVID-19) is safe for individuals either seeking pregnancy or who are pregnant. The study's authors found no effect of COVID-19 vaccination on fecundity in a population of individuals with no known infertility who were attempting...