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About 43,368 results

SARS-CoV-2 vaccine protection and deaths among US veterans during 2021
https://www.science.org/doi/10.1126/science.abm0620
Science Cohn BA, .

Nov 4th, 2021 - The messenger RNA vaccines BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna) and the viral vector vaccine JNJ-78436735 (Janssen) have effectively prevented clinically significant disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since their rollout in the U.S. in late 2020 (1, 2).

Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report
https://www.medrxiv.org/content/10.1101/2021.10.10.21264827v1.full.pdf
Medrxiv Atmar RL, .

Oct 13th, 2021 - Background: While Coronavirus disease 2019 (Covid-19) vaccines are highly effective, breakthrough infections are occurring. Booster vaccinations have recently received emergency use authorization (EUA) for certain populations but are restricted to homologous mRNA vaccines. We evaluated homologous and heterologous booster vaccination in persons who had received an EUA Covid-19 vaccine regimen.

An upper bound on one-to-one exposure to infectious human respiratory particles.
https://doi.org/10.1073/pnas.2110117118
Proceedings of the National Academy of Sciences of the Un... Bagheri G, Thiede B et. al.

Dec 4th, 2021 - There is ample evidence that masking and social distancing are effective in reducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. However, due to the complexity of airborne disease transmission, it is difficult to quantify their effectiveness, especially in the case of one-to-one exposure. Here, we introduce the concept of an upper bound for one-to-one exposure to ...

Retrospective evaluation of an observational cohort by the Central and Eastern Europe N...
https://doi.org/10.1111/hiv.13214
HIV Medicine; Lakatos B, Kowalska J et. al.

Dec 4th, 2021 - The aim of this international multicentre study was to review potential drug-drug interactions (DDIs) for real-life coadministration of combination antiretroviral therapy (cART) and coronavirus disease 2019 (COVID-19)-specific medications. The Euroguidelines in Central and Eastern Europe Network Group initiated a retrospective, observational cohort study of HIV-positive patients diagnosed with ...

Insufficient response to mRNA SARS-CoV-2 vaccine and high incidence of severe COVID-19 ...
https://doi.org/10.1111/ajt.16902
American Journal of Transplantation : Official Journal Of... Reischig T, Kacer M et. al.

Dec 4th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination may fail to sufficiently protect transplant recipients against coronavirus disease 2019 (COVID-19). We retrospectively evaluated COVID-19 in kidney transplant recipients (n=226) after BNT162b2 mRNA vaccine administration. The control group consisted of unvaccinated patients (n=194) during the previous pandemic wave. W...

Observational study on the benefit of a nutritional supplement, supporting immune funct...
https://doi.org/10.1016/j.clnesp.2021.08.031
Clinical Nutrition ESPEN; Rossato MS, Brilli E et. al.

Dec 4th, 2021 - Recent studies have verified that the SARS-CoV-2 infection (from December 2019 has affected 123 million people throughout the world and more than 3 million people in Italy), can have medium-term and long-term effects, collectively referred to as "post-Covid syndrome" or "long-Covid" characterized by chronic fatigue, followed by muscle weakness, dyspnea and headache. Chronic fatigue or chronic t...

Characteristics of Children Diagnosed With SARS-CoV-2 in the Ambulatory Setting.
https://doi.org/10.1177/00099228211064378
Clinical Pediatrics; Guo N, Crim K et. al.

Dec 4th, 2021 - The objective of this study was to characterize the clinical presentation and outcomes of children and adolescents testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the ambulatory setting. We found that about 8% of children tested positive for SARS-CoV-2, with the large majority being symptomatic (80%). The average age of our population was 12.5 years, and fem...

Spectrum of SARS-CoV-2-Related Clinical Syndromes in Children: A Year in the Life.
https://doi.org/10.1177/00099228211064655
Clinical Pediatrics; Khan M, Dang L et. al.

Dec 4th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a wide pediatric clinical spectrum. Initial reports suggested that children had milder symptoms compared with adults; then diagnosis of multisystem inflammatory syndrome in children (MIS-C) emerged. We performed a retrospective cohort study of hospitalized patients at a children's hospital over 1 year. Our objectives were to study...

The persistent challenges faced by vascular surgery services during the UK coronavirus ...
https://doi.org/10.1308/rcsann.2021.0202
Annals of the Royal College of Surgeons of England; Nandhra S, Benson RA et. al.

Dec 4th, 2021 - The coronavirus (COVID-19) pandemic continues to affect the NHS. The Vascular and Endovascular Research Network (VERN) COvid Vascular sERvice (COVER) study has prospectively shown the significant global impact of the COVID-19 pandemic on vascular surgery. The aim of this study is to investigate the way in which this second wave has affected surgeons' ability to treat patients with urgent vascul...

Probable Transmission of SARS-CoV-2 Omicron Variant in Quarantine Hotel, Hong Kong, Chi...
https://doi.org/10.3201/eid2802.212422
Emerging Infectious Diseases; Gu H, Krishnan P et. al.

Dec 4th, 2021 - We report detection of severe acute respiratory syndrome coronavirus 2 Omicron variant (B.1.1.529) in an asymptomatic, fully vaccinated traveler in a quarantine hotel in Hong Kong, China. The Omicron variant was also detected in a fully vaccinated traveler staying in a room across the corridor from the index patient, suggesting transmission despite strict quarantine precautions.

Use of Cardiopulmonary Stress Testing for Patients With Unexplained Dyspnea Post-Corona...
https://doi.org/10.1016/j.jchf.2021.10.002
JACC. Heart Failure; Mancini DM, Brunjes DL et. al.

Dec 4th, 2021 - The authors used cardiopulmonary exercise testing (CPET) to define unexplained dyspnea in patients with post-acute sequelae of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection (PASC). We assessed participants for criteria to diagnose myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Approximately 20% of patients who recover from coronavirus disease (COVID) remai...

Coronavirus Disease 2019 (COVID-19) Antibody Plasma Research Study in Hospitalized Patients
https://clinicaltrials.gov/ct2/show/NCT04524507

Dec 3rd, 2021 - This randomized, double-blinded, phase 2 trial will assess the efficacy and safety of anti-SARS-CoV-2 convalescent plasma in hospitalized patients with less than 8 days of symptoms. Eligible participants will receive institutional-guided standard-of-care (SOC) and ABO-compatible convalescent COVID-19 plasma (CCP). The CCP units will be tested for the presence of anti-SARS-CoV-2 antibodies and p...

Sirolimus in COVID-19 Phase 1
https://clinicaltrials.gov/ct2/show/NCT04371640

Dec 3rd, 2021 - This is a double-blinded, two-arm, randomized, placebo controlled study comparing the virological efficacy of add-on sirolimus with standard care to placebo and standard care. Virological efficacy is defined as the change from baseline to day 7 in SARS-CoV-2 viral burden measured by quantitative real-time polymerase chain reaction.

"Facemask Use During High-intensity Interval Exercise in Temperate and Hot Environments"
https://clinicaltrials.gov/ct2/show/NCT05143801

Dec 3rd, 2021 - Mask use in public settings is recommended to limit the spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that causes the disease known as COVID-19 and endorsed by the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO). Wearing a mask during exercise may have implications for recreational exercisers and athletes that train and compete a...

Safety and Immunogenicity Study of 2019-nCoV Vaccine (mRNA-1273) for Prophylaxis of SARS-CoV-2 Infection (COVID-19)
https://clinicaltrials.gov/ct2/show/NCT04283461

Dec 3rd, 2021 - This is a phase I, open-label, dose-ranging clinical trial in males and non-pregnant females, starting at 18 years of age, inclusive, who are in good health and meet all eligibility criteria. This clinical trial is designed to assess the safety, reactogenicity and immunogenicity of mRNA-1273 manufactured by ModernaTX, Inc. mRNA-1273 is a novel lipid nanoparticle (LNP)-encapsulated mRNA-based va...

Advances in laboratory detection methods and technology application of SARS-CoV-2.
https://doi.org/10.1002/jmv.27494
Journal of Medical Virology; Zhang X, Meng H et. al.

Dec 3rd, 2021 - At present, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is raging worldwide, and the COVID-19 outbreak caused by SARS-CoV-2 seriously threatens the life and health of all humankind. There is no specific medicine for novel coronavirus yet. So, laboratory diagnoses of novel coronavirus as soon as possible and isolation of the source of infection play a vital role in preventing an...

Drug Repurposing strategies and key challenges for Covid-19 management.
https://doi.org/10.1080/1061186X.2021.2013852
Journal of Drug Targeting; Mule S, Singh A et. al.

Dec 3rd, 2021 - Covid- 19 is a clinical outcome of viral infection emerged due to strain of beta coronavirus which attacks the type-2 pneumocytes in alveoli via ACE2 receptors. There is no satisfactory drug therapeutic is developed against "SARS-CoV2", highlighting needs of an immediate necessity to give a thorough insight on using chemotherapeutic repurposing plan for the develop COVID-19 infected patients tr...

Patients presenting high fever with lymphadenopathy after COVID-19 vaccination were dia...
https://doi.org/10.1080/23744235.2021.2010801
Infectious Diseases (London, England); Baek DW, Hwang S et. al.

Dec 3rd, 2021 - The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still continuing worldwide. Currently, two mRNA-based vaccines and two DNA vaccines using an adenovirus vector are representative vaccines. Since the SARS-CoV-2 vaccines began to be administered, a significant decrease in new infections and COVID-19-associated death has...

SARS-CoV-2 spike protein displays sequence similarities with paramyxovirus surface prot...
https://doi.org/10.1371/journal.pone.0260360
PloS One; Ahmadi E, Zabihi MR et. al.

Dec 3rd, 2021 - Recent emergence of SARS-CoV-2 and associated COVID-19 pandemic have posed a great challenge for the scientific community. In this study, we performed bioinformatic analyses on SARS-CoV-2 protein sequences, trying to unravel potential molecular similarities between this newly emerged pathogen with non-coronavirus ssRNA viruses. Comparing the proteins of SARS-CoV-2 with non-coronavirus positive ...

Infection with SARS-CoV-2 among children with asthma: evidence from Global Asthma Network.
https://doi.org/10.1111/pai.13709
Pediatric Allergy and Immunology : Official Publication O... Chiang CY, Ellwood P et. al.

Dec 3rd, 2021 - Clinical presentations of coronavirus disease 2019 (COVID-19) among children with asthma have rarely been investigated. This study aimed to assess clinical manifestations and outcome of COVID-19 among children with asthma, and whether the use of asthma medications was associated with outcomes of interest. The Global Asthma Network (GAN) conducted a global survey among GAN centres. Data collecti...