About 286,828 results

Proficiency, flexibility help match patients with appropriate MIGS device

Feb 7th, 2022 - WAIKOLOA, Hawaii — With several good MIGS options, the choice often comes down to matching the procedure with the patient, according to a presentation at Hawaiian Eye 2022. John Berdahl, MD, said devices such as the Hydrus microstent (Ivantis/Alcon) and the iStent (Glaukos) have shown efficacy in reducing IOP and medications in patients with glaucoma. “So, how do you choose?” Berdahl said. “I a...

Be cautious if considering use of premium IOLs in patients with glaucoma

Jan 21st, 2022 - WAIKOLOA, Hawaii — Surgeons need to consider the risks and possible refractive outcomes before implanting a premium IOL in a patient with glaucoma, according to a presentation at Hawaiian Eye 2022. Nathan Radcliffe, MD, said that when a patient with glaucoma who already has a premium IOL experiences a problem, the IOL is rarely the issue. “I never remove the premium IOL because as bad as the gl...

Glaucoma treatment should be tailored to individual patients

Jan 20th, 2022 - WAIKOLOA, Hawaii — Clinical research, personal experience, physician skill set, patient factors and goals all influence the decision to perform trabeculectomy or use a tube shunt, a speaker said here at Hawaiian Eye 2022. “Individualize the treatment choice to the patient in front of you,” Brian E. Flowers, MD, said. If the IOP target is low or if the patient is younger or has medication tolera...

Retinal fluorescence imaging helps identify early functional changes

Jan 19th, 2022 - WAIKOLOA, Hawaii — Fluorescence imaging can be an important tool for early detection of retinal diseases, according to a presentation at Retina 2022. Rishi P. Singh, MD, said that technologies such as fundus autofluorescence (FAF), fluorescence lifetime imaging ophthalmoscopy (FLIO) and oxidized flavoprotein fluorescence (FPF) provide opportunities to identify cell dysfunction before it occurs....

Consensus group provides imaging criteria for assessment of geographic atrophy

Jan 19th, 2022 - WAIKOLOA, Hawaii — In a series of published reports, the Classification of Atrophy Meeting group provided consensus-based imaging parameters for multimodal assessment of geographic atrophy. The group also revised the definitions of specific features of geographic atrophy (GA) and identified features that may predict progression to atrophy. “In the first CAM report, we described the imaging moda...

How to avoid the perils of uveitis diagnostic management

Jan 16th, 2022 - WAIKOLOA, Hawaii — It is important for physicians to consider “the perils that dwell” in the diagnostic management of patients with uveitis, Steven Yeh, MD, said during a presentation at Hawaiian Eye 2022. “With these patients being very complex oftentimes, we really just don’t want to miss something,” Yeh said. To better identify “the pearls amongst the perils” in uveitis diagnosis, it is impo...

Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT)
BMJ Jolliffe D A, Holt H et. al.

Sep 7th, 2022 - The covid-19 pandemic has refocused attention on strategies to prevent acute respiratory tract infection. Although vaccination against SARS-CoV-2 represents the mainstay for disease control, its effectiveness at a global level is compromised by factors such as cost, availability, vaccine hesitancy, vaccine failure, and vaccine escape.123 Complementary, low cost approaches to enhance immunity to...

Awareness of SARS-CoV-2 Omicron Variant Infection Among Adults With Recent COVID-19 Seropositivity
JAMA Network Open; Joung SY, Ebinger JE et. al.

Aug 17th, 2022 - The rapid spread of the SARS-CoV-2 Omicron variant across communities worldwide has been attributed to several factors, including transmissibility features of the viral variant, limited coverage by available vaccines, and changes in face mask use and socializing behaviors.1,2 In particular, alterations of the Omicron variant have been implicated because of its greater transmissibility compared ...

Mortality Prognostic Factors of Critically Ill Patients with Systemic Autoimmune Diseases Admitted in a Medical Intensive Care Unit: A 20-year Cohort Study
Pamela Doti, Ana Luisa Cunha, Armin Quispe Cornejo et. al.

Nov 14th, 2022 - Background/Purpose: To describe the clinical characteristics of a 20-year cohort of patients with systemic autoimmune diseases (SAD) admitted to a medical intensive care unit (ICU) and to identify mortality prognostic factors. Methods: A single-center retrospective, observational study including all adult patients with SAD admitted to a medical ICU of a tertiary referral center between 1999 and...

Vaccine Hesitancy Among Patients with Idiopathic Inflammatory Myopathies and Rheumatic Diseases in 2021-2022: A Comparative Analysis of COVID-19 Vaccination in Autoimmune Diseases Surveys
Naveen R, Mrudula Joshi, Parikshit Sen et. al.

Nov 14th, 2022 - Background/Purpose: Patients with comorbidities and active rheumatic disease have increased morbidity and hospitalization following SARS-CoV-2 infection. While vaccination has decreased this, many unknown factors still influence COVID-19 vaccine hesitancy. The data on predictors of vaccine hesitancy is regional and scarce. We aimed to analyze the factors influencing vaccine hesitancy in 2022 an...

Analysis of the Association Between the Atrophic Factors Tripartite Motif Containing (TRIM) 63 and Atrogin-1 and the Clinical and Inflammatory Features of Patients with Idiopathic Inflammatory Myop...
jiram torres-Ruiz, Abdiel Absalón-Aguilar, Juan Alberto Reyes-Islas et. al.

Nov 14th, 2022 - Background/Purpose: Muscle atrophy is mediated by the ubiquitination of myofilaments by two ubiquitin ligases called Tripartite Motif Containing (TRIM) 63 and Atrogin-1, which are induced by inflammation and interferons (IFN). Muscle atrophy is the main cause of disability in patients with idiopathic inflammatory myopathies (IIM), but notwithstanding its relevance, the expression of TRIM63 and ...

Urinary Beta-2 Microglobulin Is a Sensitive Prognostic Marker in Dermatomyositis Patients with Interstitial Lung Disease Positive for Anti-MDA-5 Antibody
Jun Nakamura, Takao Nagashima and Kojiro Sato, Jichi Medical University et. al.

Nov 14th, 2022 - Background/Purpose: Interstitial Lung Disease (ILD) accompanied with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM) is usually rapidly progressive and life-threatening with poor prognosis. Although serum ferritin has been reported as a prognostic marker for ILD among patients with anti-MDA5 antibody positive DM, serum ferritin levels does not neces...

Differentiation of Injury-associated Macrophages in Lupus Kidneys Is Conserved in Humans and Lupus Mouse Models
Paul Hoover, David Lieb, Stephen Li et. al.

Nov 14th, 2022 - Background/Purpose: Infiltrating monocytes acquire functions that support kidney remodeling in response to tissue damage in lupus nephritis. This process of monocyte differentiation has been difficult to study due to the inability to characterize immune cells from small human kidney biopsies or to accurately use mouse models to investigate mechanisms relevant to human disease. We previously rep...

Extreme Phenotype Approach Identifies Rare Variants in Systemic Sclerosis and Dermatomyositis Patients with Severe Calcinosis
Srijana Davuluri, Urvashi Kaundal, Christian Lood et. al.

Nov 14th, 2022 - Background/Purpose: Calcinosis, deposition of insoluble calcium salts in skin and subcutaneous tissues, affects up to 40% of systemic sclerosis (SSc) patients, and up to 20% of adult dermatomyositis (DM) patients. It contributes to a significant disease burden as patients suffer from pain, ulceration, and secondary infections. The genetics of calcinosis in SSc and DM has not been investigated a...

Sociocultural and Moral Factors Influencing the Decision to Vaccinate Among Rheumatic Patients: A Qualitative Study
Tirsa Colmenares-Roa, Amaranta ManriquedeLara, Virginia Pascual Ramos et. al.

Nov 14th, 2022 - Background/Purpose: Vaccination is a process that involves individual, social and moral aspects, beyond public governance of vaccines or vaccination as a public health concern. The ways people incorporate their beliefs and concerns into vaccine decision-making affect the effectiveness of these interventions for individual and community health. The aim of this study is to describe the sociocultu...

Psychosocial and Health Measures in Systemic Lupus Erythematosus: COVID-19 Pandemic Trends in the Georgians Organized Against Lupus Cohort
Charmayne Dunlop-Thomas, Gaobin Bao, Jessica Williams et. al.

Nov 14th, 2022 - Background/Purpose: The COVID-19 pandemic may have a sustained impact on systemic lupus erythematosus (SLE) patients in multiple ways. In a large predominantly Black SLE cohort, we explored trends in lupus disease activity, general health, and psychosocial factors at 3-time points: pre-pandemic, early pandemic, and later pandemic. Methods: We examined longitudinal data from people with SLE enro...

Utilization of Electronic Health Record Data to Evaluate the Impact of Urban Environment on Risk of Systemic Lupus Erythematosus Symptoms
Janet Song, Noah Forrest, Kathleen Mittendorf et. al.

Nov 14th, 2022 - Background/Purpose: Systemic Lupus Erythematosus (SLE) has a complex and poorly understood etiology and is difficult to diagnose due to its varied presentation across many organ systems. While we know genetic factors and environmental exposures contribute to SLE development, there is still much variability not explained by genetics or exposures. Socioeconomic factors such as race have also been...

Sex-Related Differences in Healthcare Utilization in Patients with Inflammatory Arthritis: A Population-based Study
Sanjana Tarannum, Jessica Widdifield, C. Fangyun Wang et. al.

Nov 14th, 2022 - Background/Purpose: Delayed diagnosis of inflammatory arthritis (IA), including rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA), is associated with joint damage and disability. Thus, timely rheumatology access is necessary for favorable disease outcomes. Sex of the patient may influence various aspects of IA including healthcare utilization patterns. Our aim...

Epidemiology and Outcomes of Raynaud’s Phenomenon Hospitalizations in the US
Rashmi Dhital, Monica Guma, Thuthiri Lwin et. al.

Nov 14th, 2022 - Background/Purpose: The prevalence of Raynaud’s phenomenon (RP) in the general population is ~3-5%, of which 80–90% are primary. Autoimmune diseases are the most common causes of secondary RP, others may include vibrating tools, drugs, hematologic, vascular, or neurological diseases. A seasonal pattern with worsening RP in winter has been observed. However, the impact on RP hospitalizations in ...

Sex Differences in Autoimmune Pathogenesis and Systemic Response to High Fat Diet in Lupus-prone Mice
Gitanjali Lobo, Juan Meng, Xuhua Shi et. al.

Nov 14th, 2022 - Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation and the production of autoantibodies, leading to systemic multiorgan damage. SLE has been reported with diverse prevalence and clinical phenotypes of varying severity, which may be caused by sex hormones, genetic and epigenetic factors, and gut microbiota. Our recent studies sho...