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About 309,955 results

Proficiency, flexibility help match patients with appropriate MIGS device
https://www.healio.com/news/ophthalmology/20220207/proficiency-flexibility-help-match-patients-with-appropriate-migs-device

Feb 7th, 2022 - WAIKOLOA, Hawaii — With several good MIGS options, the choice often comes down to matching the procedure with the patient, according to a presentation at Hawaiian Eye 2022. John Berdahl, MD, said devices such as the Hydrus microstent (Ivantis/Alcon) and the iStent (Glaukos) have shown efficacy in reducing IOP and medications in patients with glaucoma. “So, how do you choose?” Berdahl said. “I a...

Be cautious if considering use of premium IOLs in patients with glaucoma
https://www.healio.com/news/ophthalmology/20220121/be-cautious-if-considering-use-of-premium-iols-in-patients-with-glaucoma

Jan 21st, 2022 - WAIKOLOA, Hawaii — Surgeons need to consider the risks and possible refractive outcomes before implanting a premium IOL in a patient with glaucoma, according to a presentation at Hawaiian Eye 2022. Nathan Radcliffe, MD, said that when a patient with glaucoma who already has a premium IOL experiences a problem, the IOL is rarely the issue. “I never remove the premium IOL because as bad as the gl...

Glaucoma treatment should be tailored to individual patients
https://www.healio.com/news/ophthalmology/20220120/glaucoma-treatment-should-be-tailored-to-individual-patients

Jan 20th, 2022 - WAIKOLOA, Hawaii — Clinical research, personal experience, physician skill set, patient factors and goals all influence the decision to perform trabeculectomy or use a tube shunt, a speaker said here at Hawaiian Eye 2022. “Individualize the treatment choice to the patient in front of you,” Brian E. Flowers, MD, said. If the IOP target is low or if the patient is younger or has medication tolera...

Retinal fluorescence imaging helps identify early functional changes
https://www.healio.com/news/ophthalmology/20220119/retinal-fluorescence-imaging-helps-identify-early-functional-changes

Jan 19th, 2022 - WAIKOLOA, Hawaii — Fluorescence imaging can be an important tool for early detection of retinal diseases, according to a presentation at Retina 2022. Rishi P. Singh, MD, said that technologies such as fundus autofluorescence (FAF), fluorescence lifetime imaging ophthalmoscopy (FLIO) and oxidized flavoprotein fluorescence (FPF) provide opportunities to identify cell dysfunction before it occurs....

Consensus group provides imaging criteria for assessment of geographic atrophy
https://www.healio.com/news/ophthalmology/20220119/consensus-group-provides-imaging-criteria-for-assessment-of-geographic-atrophy

Jan 19th, 2022 - WAIKOLOA, Hawaii — In a series of published reports, the Classification of Atrophy Meeting group provided consensus-based imaging parameters for multimodal assessment of geographic atrophy. The group also revised the definitions of specific features of geographic atrophy (GA) and identified features that may predict progression to atrophy. “In the first CAM report, we described the imaging moda...

How to avoid the perils of uveitis diagnostic management
https://www.healio.com/news/ophthalmology/20220116/how-to-avoid-the-perils-of-uveitis-diagnostic-management

Jan 16th, 2022 - WAIKOLOA, Hawaii — It is important for physicians to consider “the perils that dwell” in the diagnostic management of patients with uveitis, Steven Yeh, MD, said during a presentation at Hawaiian Eye 2022. “With these patients being very complex oftentimes, we really just don’t want to miss something,” Yeh said. To better identify “the pearls amongst the perils” in uveitis diagnosis, it is impo...

Prevalence and Factors Associated With Antigen Test Positivity Following SARS-CoV-2 Infection Among Health Care Workers in Los Angeles
https://academic.oup.com/ofid/article/9/10/ofac462/6762879
Open Forum Infectious Diseases; Adamson PC, .

Oct 19th, 2022 - Surges of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among health care workers (HCWs) have led to critical staffing shortages. From January 4 to February 4, 2022, we implemented a return-to-work antigen testing program for HCWs, and 870 HCWs participated. Antigen test positivity was 60.5% for those ≤5 days from symptom onset or positive polymerase chain reaction (PC...

Prevalence of Positive Rapid Antigen Tests After 7-Day Isolation Following SARS-CoV-2 Infection in College Athletes During Omicron Variant Predominance
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2797450
JAMA Network Open; Tsao J, Kussman A et. al.

Oct 18th, 2022 - One of the cornerstones of management during the COVID-19 pandemic has been to isolate individuals with infection to prevent viral spread. Guidelines for most of the pandemic have recommended 10 days of isolation.1 However, this prolonged period of isolation can lead to lost wages, workforce shortages, and other negative socioeconomic factors.

Lipid biomarkers that reflect postoperative recurrence risk in lung cancer patients who...
https://doi.org/10.1186/s12944-023-01778-3
Lipids in Health and Disease; Takanashi Y, Kahyo T et. al.

Jan 29th, 2023 - The risk of postoperative recurrence is higher in lung cancer patients who smoke than non-smokers. However, objective evaluation of the postoperative recurrence risk is difficult using conventional pathological prognostic factors because of their lack of reproducibility. Consequently, novel objective biomarkers that reflect postoperative risk in lung cancer patients who smoke must be identified...

Identification and validation of pyroptosis-related gene landscape in prognosis and imm...
https://doi.org/10.1186/s13048-022-01065-2
Journal of Ovarian Research; Gao L, Ying F et. al.

Jan 29th, 2023 - Emerging evidence has highlighted the biological significance of pyroptosis in tumor tumorigenesis and progression. Nonetheless, the potential roles of pyroptosis in tumor immune microenvironment and target therapy of ovarian cancer (OC) remain unknown. In this study, with a series of bioinformatic and machine learning approaches, we comprehensively evaluated genetic alterations and transcripto...

Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upr...
https://doi.org/10.1186/s13024-023-00597-5
Molecular Neurodegeneration; Kisler K, Sagare AP et. al.

Jan 29th, 2023 - PICALM is one of the most significant susceptibility factors for Alzheimer's disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium. PICALM endothelial levels are reduced in AD brains. PICALM controls several steps in Aβ transcytosis across the blood-brain barrier (BBB). Its loss from brain endothelium in mice diminishes Aβ clearance at the BBB, which worsens Aβ patho...

Infections in travellers returning to the UK: a retrospective analysis (2015-2020).
https://doi.org/10.1093/jtm/taad003
Journal of Travel Medicine; Warner JC, Hatziioanou D et. al.

Jan 29th, 2023 - Every year, many thousands of travellers return to the United Kingdom (UK) from visits to other countries and some will become unwell due to infections acquired abroad. Many imported infections have similar clinical presentations, such as fever and myalgia, so diagnostic testing is an important tool to improve patient management and outcomes. The aim of this study was to examine the demographic...

High expression of LOC541471, GDAP1, SOD1, and STK25 is associated with poor overall su...
https://doi.org/10.1002/cam4.5644
Cancer Medicine; Yu X, Chen C et. al.

Jan 29th, 2023 - Acute myeloid leukemia (AML) is an aggressive heterogeneous hematological malignancy with remarkably heterogeneous outcomes. This study aimed to identify potential biomarkers for AML risk stratification via analysis of gene expression profiles. RNA sequencing data from 167 adult AML patients in the Cancer Genome Atlas (TCGA) database were obtained for overall survival (OS) analysis, and 52 bone...

Clinical characteristics and serum CA19-9 combined with HE4 are valuable in diagnosing ...
https://doi.org/10.1002/ijgo.14695
International Journal of Gynaecology and Obstetrics: the ... Xu T, Zhang L et. al.

Jan 29th, 2023 - Endometriosis associated ovarian cancer (EAOC) is difficult to diagnose as low incidence, uncertain risk factors, and absence of effective markers. This study aimed to investigate clinical characteristics of EAOC and identify useful serological markers. We retrospectively studied clinical characteristics of 220 patients, of which 44 with EAOC and 176 with ovarian endometriosis (OEM), obtained f...

Transmission of Mpox: A narrative review of environmental, viral, host and population f...
https://doi.org/10.1002/jmv.28534
Journal of Medical Virology; Pan D, Nazareth J et. al.

Jan 29th, 2023 - Monkeypox virus (mpox) has spread globally. Emerging studies have now provided evidence regarding mpox transmission, that can inform rational evidence-based polices and reduce misinformation on this topic. We aimed to review the evidence on transmission of the virus. Real-world studies have isolated viable virus from high touch surfaces for as long as 15 days. Strong evidence suggests that curr...

Patient characteristics and factors contributing to recurrence of bacterial vaginosis p...
https://doi.org/10.1093/fampra/cmad005
Family Practice; Delfstra NS, Uijen AA et. al.

Jan 29th, 2023 - Bacterial vaginosis (BV) is a common problem in primary care. BV symptoms often have a negative impact on patients' quality of life and may predispose to gynaecological problems. Some patients experience recurring episodes of BV. This study's objective is to identify possible factors that may be associated with BV recurrence and describe the characteristics of these patients and interventions p...

Clinical characteristics and quality of life in patients with inflammatory bowel diseas...
https://doi.org/10.1097/MEG.0000000000002511
European Journal of Gastroenterology & Hepatology; Xue M, Chen J et. al.

Jan 29th, 2023 - Clinical characteristics of inflammatory bowel disease (IBD) with anemia have not been fully elucidated. This study aimed to investigate the frequency of, risk factors for, and management of anemia in IBD patients and to evaluate the quality of life (QOL) in IBD patients with anemia. We included two patient cohorts. In cohort 1, clinical data from 697 IBD patients were retrospectively collected...

Autism spectrum disorder and personality disorders: How do clinicians carry out a diffe...
https://doi.org/10.1177/13623613231151356
Autism : the International Journal of Research and Practice; Allely CS, Woodhouse E et. al.

Jan 29th, 2023 - It is now recognised that autism spectrum disorder (ASD) and personality disorders (PDs) have a variety of factors in common. However, the exact nature of the relationship between ASD and the PDs remains unclear. The overlapping symptom profiles of ASD and PDs can lead to diagnostic uncertainty - features of ASD and PD can be misattributed and easily lead to misdiagnosis of ASD patients. Since ...

Status and related factors of postoperative recurrence of ovarian endometriosis: a cros...
https://doi.org/10.1007/s00404-023-06932-x
Archives of Gynecology and Obstetrics; Yang X, Bao M et. al.

Jan 29th, 2023 - Exploring the status and related factors of postoperative recurrence of ovarian endometriosis. This study analyzed the results of questionnaires conducted in 27 hospitals across the country from January 2019 to November 2021. All women were divided into recurrence group and non-recurrence group to analyze the recurrence rate and related factors after ovarian endometriosis surgery. The recurrenc...

Epidemiology, course, and outcomes of Sars-CoV-2 infection in patients with acromegaly ...
https://doi.org/10.1007/s40618-023-02016-4
Journal of Endocrinological Investigation; Ragonese M, Giuffrida G et. al.

Jan 29th, 2023 - Acromegaly (AC) and Cushing's disease (CD) increase morbidity and mortality due to cardio-metabolic alterations, and overall cause frailty in the affected patients, potentially making them more susceptible to infective diseases. However, up to now, very few studies evaluated the course of COVID-19 disease in this setting. We investigated epidemiology, course, and outcomes of COVID-19 disease in...