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About 202,100 results

Molecular signature of brain arteriovenous malformation hemorrhage: a systematic review.
https://doi.org/10.1016/j.wneu.2021.10.114
World Neurosurgery; Germans MR, Sun W et. al.

Oct 24th, 2021 - The mechanisms of brain arteriovenous malformation (bAVM) development, formation and progress are still poorly understood. By gaining more knowledge about the molecular signature of bAVM in relation to hemorrhage, we might be able to find biomarkers associated with this serious complication, which can function as a goal for further research and can be a potential target for gene therapy. To pro...

In vitro and in vivo therapeutic potentials of 6-gingerol in combination with amphoteri...
https://doi.org/10.1016/j.intimp.2021.108274
International Immunopharmacology; Keyhani A, Sharifi I et. al.

Oct 24th, 2021 - The ongoing conventional drugs for leishmaniasis treatment are insufficient. The present study aimed to assess 6-gingerol alone and in combination with amphotericin B on Leishmania major stages using experimental and in vivo murine models. Here, arrays of experimental approaches were designed to monitor and evaluate the 6-gingerol potential therapeutic outcomes. The binding affinity of 6-ginger...

Paediatric tuberculosis preventive treatment preferences among HIV-positive children, c...
https://doi.org/10.1136/bmjopen-2020-048443
BMJ Open; Hirsch-Moverman Y, Strauss M et. al.

Oct 24th, 2021 - Isoniazid preventive therapy initiation and completion rates are suboptimal among children. Shorter tuberculosis (TB) preventive treatment (TPT) regimens have demonstrated safety and efficacy in children and may improve adherence but are not widely used in high TB burden countries. Understanding preferences regarding TPT regimens' characteristics and service delivery models is key to designing ...

Prevalence and factors associated with diabetes mellitus among tuberculosis patients in...
https://doi.org/10.1136/bmjopen-2021-050542
BMJ Open; Rajaa S, Krishnamoorthy Y et. al.

Oct 24th, 2021 - To determine the prevalence and determinants of diabetes mellitus (DM) among tuberculosis (TB) patients and to assess the additional yield and number needed to screen (NNS) to obtain a newly diagnosed DM among TB patients. We undertook a cross-sectional analysis of the cohort data under Regional Prospective Observational Research for Tuberculosis-India consortium. Newly diagnosed TB patients re...

Glioma: molecular signature and crossroads with tumor microenvironment.
https://doi.org/10.1007/s10555-021-09997-9 10.1007/s00109-009-0440-9 10.1101/gad.261982.115.tumors 10.1016/j.trecan.2020.01.009 10.1172/JCI89587 10.1007/978-3-030-49270-0_11 10.1016/j.cmet.2019.06.001 10.1212/WNL.0000000000002770 10.1016/j.tranon.2019.10.002 10.3390/cancers11030292 10.1093/neuonc/now005 10.1111/cas.13826 10.1038/s41392-021-00499-2 10.1007/s00401-016-1545-1 10.3389/fimmu.2019.03137 10.1042/BST20180444 10.3390/IJMS160511055 10.1146/annurev-physiol-021119-034627 10.3892/ijmm.2016.2639 10.1158/0008-5472.CAN-17-3551 10.1038/sigtrans.2017.40 10.1093/neuonc/nox054 10.1016/j.neo.2018.11.007 10.1038/nm1517 10.1016/j.jocn.2010.04.021 10.1016/j.ccell.2019.05.003 10.1016/S0945-053X(98)90012-9 10.1002/stem.415 10.3389/FCELL.2021.600506 10.1093/carcin/bgu134 10.1158/0008-5472.CAN-16-2832 10.1097/NEN.0b013e31823fe8f1 10.1158/0008-5472.CAN-11-1031 10.1016/j.trecan.2015.10.009 10.1371/journal.pone.0003655 10.1083/jcb.84.3.495 10.1124/pr.117.014944 10.1007/s00726-011-0867-5 10.3390/ijms20071796 10.1038/NCB1725 10.3390/ijms18112342 10.1186/S12964-020-00589-8 10.1038/onc.2011.563 10.1158/1078-0432.CCR-18-2402 10.3390/ijms20215347 10.1007/s11910-013-0345-4 10.1016/j.jneuroim.2016.05.019 10.1038/s41598-019-47021-x 10.1007/s00401-018-1842-y 10.1038/s41580-019-0134-2 10.1002/(SICI)1098-1136(199903)26:1<55::AID-GLIA6>3.0.CO;2-1 10.1007/s00401-009-0550-z 10.1007/s00401-004-0929-9 10.1007/s00401-011-0802-6 10.3390/cancers12010114 10.1186/s12885-019-6177-0 10.1038/ncomms7999 10.1056/NEJMoa043331 10.1016/j.cell.2013.03.020 10.1038/nature05529 10.1038/s41418-018-0126-3 10.3389/fonc.2018.00164 10.1038/oncsis.2014.36 10.1158/0008-5472.CAN-11-3732 10.1126/science.6320372 10.1002/ana.410360505 10.3390/cancers11091220 10.1097/CCO.0b013e32835b639e 10.1159/000495920 10.1007/S00401-003-0810-2 10.1186/s40425-019-0536-x 10.1016/S0165-5728(99)00203-9 10.1038/s41598-020-72488-4 10.3389/FIMMU.2020.585034 10.1215/15228517-2007-035 10.1016/j.ccell.2017.02.009 10.1515/ISS-2019-0001 10.1186/S12885-019-6384-8 10.1016/j.prp.2020.153141 10.1158/ajc.1938.333 10.1158/0008-5472.CAN-06-1010 10.1016/j.ccr.2006.11.020 10.1080/10717544.2017.1386731 10.1038/s41419-019-1387-6 10.1007/s11060-010-0261-2 10.1073/pnas.102660199 10.1006/cyto.2003.2008 10.1038/sj.onc.1202217 10.1038/nrc.2017.77 10.1038/ncomms5196 10.1016/j.cell.2013.02.021 10.1155/2016/9768183 10.1016/j.jns.2020.116837 10.1038/s41388-020-1308-2 10.1158/0008-5472.CAN-13-2650 10.1007/S12035-018-1385-1 10.1074/mcp.RA118.000644 10.1038/NCB1800 10.1593/neo.05583 10.1007/s11864-019-0619-4 10.3389/fimmu.2020.603911 10.1158/1078-0432.CCR-15-0428 10.1158/0008-5472.CAN-14-0296 10.1016/S1470-2045(12)70090-6 10.1001/jamaoncol.2020.1024 10.1158/1078-0432.CCR-16-0506 10.1186/s12967-017-1202-z 10.1093/neuonc/nou348 10.1093/neuonc/not203 10.1007/s00262-016-1890-x 10.1158/1078-0432.CCR-16-2057 10.1158/1078-0432.CCR-15-2163
Cancer Metastasis Reviews; Barthel L, Hadamitzky M et. al.

Oct 24th, 2021 - In patients with glioblastoma, the average survival time with current treatments is short, mainly due to recurrences and resistance to therapy. This insufficient treatment success is, in large parts, due to the tremendous molecular heterogeneity of gliomas, which affects the overall prognosis and response to therapies and plays a vital role in gliomas' grading. In addition, the tumor microenvir...

A Comprehensive Descriptive Epidemiological and Clinical Analysis of SARS-CoV-2 in West...
https://doi.org/10.3390/ijerph182010644
International Journal of Environmental Research and Publi... Viera-Segura O, Vega-Magaña N et. al.

Oct 24th, 2021 - This study aimed to summarize the epidemiological and clinical characteristics of COVID-19 from Western Mexico people during 2020. A retrospective analysis from an electronic database of people visiting a sentinel center for molecular SARS-CoV-2 confirmatory diagnosis by RT-PCR from April to December 2020 was carried out for epidemiological and clinical description of COVID-19. Out of 23,211 pa...

The liver steatosis severity and lipid characteristics in primary biliary cholangitis.
https://doi.org/10.1186/s12876-021-01974-4 10.1136/gut.51.2.265 10.1007/s00508-012-0162-9 10.1016/j.jhep.2016.05.013 10.1016/j.jhep.2014.01.017 10.1002/hep.29367 10.1111/jgh.12134 10.1016/S2468-1253(19)30342-5 10.1016/j.jfma.2017.08.010 10.1111/hepr.12094 10.1002/hep.29800 10.1002/hep.31060 10.1111/j.1478-3231.2012.02781.x 10.1016/j.jhep.2016.12.022 10.1038/nrendo.2016.210 10.1055/s-0032-1306423 10.1016/j.jhep.2010.05.037 10.1111/j.1365-2893.2005.00655.x 10.1016/j.jhep.2011.09.013 10.1007/BF01536666 10.1016/0016-5085(85)90642-0 10.1016/j.cgh.2014.10.008 10.1038/s41598-018-29639-5 10.1016/0021-9150(87)90091-8 10.1016/j.atherosclerosis.2010.01.001 10.1111/j.1572-0241.2008.01888.x 10.1016/S0021-9150(97)06108-X 10.1002/hep.28843 10.1111/liv.12282 10.1038/2053 10.1111/apt.14960 10.1111/apt.15575 10.1016/j.arcmed.2006.09.001 10.1517/14728222.2014.997711 10.1136/gutjnl-2018-317791 10.3748/wjg.v21.i25.7683 10.1172/JCI29126 10.1172/JCI200317797 10.1002/hep.1840150518
BMC Gastroenterology; Zhang Y, Hu X et. al.

Oct 24th, 2021 - Patients with primary biliary cholangitis (PBC) often have comorbid dyslipidemia, and determining the degree of hepatic steatosis can help predict the risk of cardiovascular events in PBC patients. The aim of our study was to analyze the characteristics of lipid distribution and the degree of hepatic steatosis in PBC. We retrospectively analyzed 479 cases of PBC, chronic hepatitis B (CHB), chro...

Post-traumatic stress disorder and childhood emotional abuse are markers of subthreshol...
https://doi.org/10.1097/YIC.0000000000000380
International Clinical Psychopharmacology; Olgiati P, Serretti A

Oct 24th, 2021 - Post-traumatic stress disorder (PTSD) and childhood maltreatment (CMT: parental neglect; emotional, physical and sexual abuse) have been linked to bipolar disorder but they are also common in major depressive disorder (MDD). Our objective was to investigate their association with the bipolar spectrum and antidepressant treatment outcome in 482 outpatients with DSM-IV MDD treated in the Combinin...

Transcriptome and unique cytokine microenvironment of Castleman disease.
https://doi.org/10.1038/s41379-021-00950-3 10.1016/S1470-2045(14)70319-5 10.1111/j.1365-2559.1989.tb02110.x 10.1111/cei.13632 10.1097/00000478-199711000-00004 10.1093/ajcp/101.3.290
Modern Pathology : an Official Journal of the United Stat... Wing A, Xu J et. al.

Oct 24th, 2021 - Castleman disease (CD) represents a group of rare, heterogeneous and poorly understood disorders that share characteristic histopathological features. Unicentric CD (UCD) typically involves a single enlarged lymph node whereas multicentric CD (MCD) involves multiple lymph node stations. To understand the cellular basis of CD, we undertook a multi-platform analysis using targeted RNA sequencing,...

FRUCTOSE-1,6-BISPHOSPHATASE DEFICIENCY CAUSES FATTY LIVER DISEASE AND REQUIRES LONG-TER...
https://doi.org/10.1002/jimd.12452
Journal of Inherited Metabolic Disease; Gorce M, Lebigot E et. al.

Oct 24th, 2021 - Liver disease, occurring during pediatric or adult age, is often of undetermined cause. Some cases are probably related to undiagnosed inherited metabolic disorders. Hepatic disorders associated with fructose-1,6-bisphosphatase deficiency, a gluconeogenesis defect, are not reported in the literature. These symptoms are mainly described during acute crises, and many reports don't mention them be...

SLITRK2, an X-linked modifier of the age at onset in C9orf72 frontotemporal lobar degen...
https://doi.org/10.1093/brain/awab171
Brain : a Journal of Neurology; Barbier M, Camuzat A et. al.

Oct 24th, 2021 - The G4C2-repeat expansion in C9orf72 is the most common cause of frontotemporal dementia and of amyotrophic lateral sclerosis. The variability of age at onset and phenotypic presentations is a hallmark of C9orf72 disease. In this study, we aimed to identify modifying factors of disease onset in C9orf72 carriers using a family-based approach, in pairs of C9orf72 carrier relatives with concordant...

Role of Laser Interstitial Thermal Therapy in the Management of Primary and Metastatic ...
https://doi.org/10.1007/s11864-021-00912-6 10.1016/j.wneu.2021.02.044
Current Treatment Options in Oncology; Melnick K, Shin D et. al.

Oct 24th, 2021 - Laser interstitial thermal therapy (LITT) is a minimally invasive treatment option for brain tumors including glioblastoma, other primary central nervous system (CNS) neoplasms, metastases, and radiation necrosis. LITT employs a fiber optic coupled laser delivery probe stabilized via stereotaxis to deliver thermal energy that induces coagulative necrosis in tumors to achieve effective cytoreduc...

Eye color and the risk of skin cancer.
https://doi.org/10.1007/s10552-021-01508-z 10.5826/dpc.0702a01 10.3322/caac.21590 10.1067/mjd.2003.186 10.1016/j.ejca.2005.03.034 10.1093/aje/kws335 10.2188/jea.JE20100145 10.1177/030089169908500603 10.1111/bjd.16323 10.1002/ijc.2910620402 10.1093/oxfordjournals.aje.a010034 10.1016/j.canep.2013.05.008 10.1038/jid.2011.402 10.1111/jdv.14929 10.1093/jnci/djg075 10.1111/jdv.15680 10.1159/000472205 10.1146/annurev-genom-083118-015230 10.1111/j.1755-148X.2009.00606.x 10.1371/journal.pgen.1000074 10.1080/000155599750011778 10.1002/ajpa.20727 10.1111/bjd.17833 10.1002/ijc.10798 10.1093/ajcn/71.1.135 10.1186/s12940-016-0197-x 10.1016/j.jaad.2018.12.058 10.1093/jnci/djv294 10.1002/humu.20143 10.1016/j.ajhg.2007.11.005 10.1007/s004390100524 10.1038/jhg.2009.130 10.1086/510885
Cancer Causes & Control : CCC; Li Y, Li WQ et. al.

Oct 24th, 2021 - Melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common skin cancers. The incidence rates of all three types of skin cancers have increased in the past three decades. Light pigmentary traits have been recognized as one of the host risk factors for skin cancer, but findings on associations between eye colors and risk of skin cancers have been inconsistent.We pe...

Low prevalence of neuropathic-like pain symptoms in long-term controlled acromegaly.
https://doi.org/10.1007/s11102-021-01190-z 10.1530/endoabs.70.AEP215
Pituitary van Trigt VR, Pelsma ICM et. al.

Oct 24th, 2021 - Pain is a common symptom of acromegaly, impairing health-related quality of life (HR-QoL) significantly despite long-term disease remission. Neuropathic-like pain (NP-like) symptoms are invalidating, with great impact on HR-QoL. Studies characterizing or investigating the etiology of pain in acromegaly are scarce. Therefore, we aimed to assess NP-like symptoms in a cohort of controlled acromega...

Elevated magnetic resonance imaging measures of adipose tissue deposition in women with...
https://doi.org/10.1007/s10549-021-06419-w 10.1016/S1470-2045(13)70076-7 10.1002/pon.4239 10.1196/annals.1413.014 10.1038/s41572-019-0072-5 10.1111/j.1524-4741.2010.00983.x 10.1055/s-0036-1572538 10.1002/cam4.691 10.1016/j.ijrobp.2018.08.036 10.1016/j.breast.2018.12.009 10.1007/s12609-017-0237-8 10.1177/1358863X10364553 10.1002/jmri.25670 10.1089/lrb.2014.0039 10.1016/j.ejrad.2008.10.041 10.1002/jmri.27328 10.1007/s10549-020-05765-5 10.1089/lrb.2016.0020 10.1002/mrm.28031 10.1002/mrm.25649 10.1016/S0169-409X(01)00150-8 10.1038/nature21028 10.1016/j.mvr.2006.05.009 10.2353/ajpath.2010.090733 10.1111/bjd.15238 10.3390/ijms21072546 10.1148/radiol.13120145 10.1089/lrb.2008.1022 10.1046/j.1523-1747.1998.00184.x 10.1097/RLI.0000000000000386 10.1089/lrb.2016.0047 10.1002/nbm.4009 10.2214/ajr.183.2.1830343 10.3389/fphys.2020.00459 10.1101/gad.1955910 10.3390/jpm5030326 10.12968/hmed.2015.76.9.542 10.1097/SAP.0000000000000381 10.1016/j.bjps.2016.06.028 10.1016/j.biomaterials.2016.05.040 10.1126/scitranslmed.aal3920 10.1097/PRS.0000000000007783
Breast Cancer Research and Treatment; Crescenzi R, Donahue PMC et. al.

Oct 24th, 2021 - Breast cancer treatment-related lymphedema (BCRL) is a common co-morbidity of breast cancer therapies, yet factors that contribute to BCRL progression remain incompletely characterized. We investigated whether magnetic resonance imaging (MRI) measures of subcutaneous adipose tissue were uniquely elevated in women with BCRL. MRI at 3.0 T of upper extremity and torso anatomy, fat and muscle tissu...

Updated review on prognostic factors in mycosis fungoides and new skin lymphoma trials.
https://doi.org/10.1111/jocd.14528
Journal of Cosmetic Dermatology; Farabi B, Seminario-Vidal L et. al.

Oct 24th, 2021 - Ten-year survival rates in mycosis fungoides (MF) broadly varies, however, there is no standardized prognostic index available. This is presumably due to low prevalence, heterogeneity, and diagnostic challenges in MF. Recent studies have focused on identifying objective prognostic indices by using different parameters for survival determinants. The Cutaneous Lymphoma International Prognostic In...

Differences in the Prevalence of SARS-CoV-2 Infection and Access to Care between Italia...
https://doi.org/10.3390/ijerph182010621
International Journal of Environmental Research and Publi... Pagani G, Conti F et. al.

Oct 24th, 2021 - The northern Italian region of Lombardy has been severely affected by the COVID-19 pandemic since its arrival in Europe. However, there are only a few published studies of the possible influence of social and cultural factors on its prevalence in the general population. This cross-sectional study of the San Siro social-housing neighbourhood of Milan, which was carried about between 23 December ...

Socio-Economic Disparities in Access to Diagnostic Neuroimaging Services in the United ...
https://doi.org/10.3390/ijerph182010633
International Journal of Environmental Research and Publi... Karia A, Zamani R et. al.

Oct 24th, 2021 - Socio-economic factors affecting health care can lead to delays in diagnosis of neurological conditions, consequentially affecting treatment and morbidity rates. This inequality in health care can leave patients from lower socio-economic backgrounds more vulnerable to a poorer quality of care from health care providers in the United Kingdom (U.K.). In this systematic review, we assess the impac...

Autism Spectrum Disorder and Prenatal or Early Life Exposure to Pesticides: A Short Rev...
https://doi.org/10.3390/ijerph182010991
International Journal of Environmental Research and Publi... Miani A, Imbriani G et. al.

Oct 24th, 2021 - Background: Autism spectrum disorder (ASD) diagnoses have rapidly increased globally. Both environmental and genetic factors appear to contribute to the development of ASD. Several studies have shown a potential association between prenatal or postnatal pesticide exposure and the risk of developing ASD. Methods: We reviewed the available literature concerning the relationship between early life...

Tuberculosis Treatment Outcome and Predictors in Africa: A Systematic Review and Meta-A...
https://doi.org/10.3390/ijerph182010678
International Journal of Environmental Research and Publi... Teferi MY, El-Khatib Z et. al.

Oct 24th, 2021 - This review aimed to summarize and estimate the TB treatment success rate and factors associated with unsuccessful TB treatment outcomes in Africa. Potentially eligible primary studies were retrieved from PubMed and Google Scholar. The risk of bias and quality of studies was assessed using The Joanna Briggs Institute's (JBI) appraisal criteria, while heterogeneity across studies was assessed us...