About 129,408 results

Potential impact of WTAP and YTHDF2 on tumor immunity in lung adenocarcinoma.
Medicine Zhang X, Cai X

Nov 19th, 2022 - WTAP and N6-methyladenosine (m6A) reader proteins (YTHDF2) are N6-methyladenosine (m6A) methyltransferase and m6A reading proteins, respectively. In recent years, the tumor immune environment has received more and more attention in the progress and treatment of cancer. The aim of this study was to investigate the relationship between N6-methyladenosine (m6A) methyltransferase (WTAP)/YTHDF2 and ...

T cells specific for α-myosin drive immunotherapy-related myocarditis.
Nature Axelrod ML, Meijers WC et. al.

Nov 18th, 2022 - Immune-related adverse events, particularly severe toxicities such as myocarditis, are major challenges to the utility of immune checkpoint inhibitors (ICIs) in anticancer therapy1. The pathogenesis of ICI-associated myocarditis (ICI-MC) is poorly understood. Pdcd1-/-Ctla4+/- mice recapitulate clinicopathological features of ICI-MC, including myocardial T cell infiltration2. Here, using single-...

Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer.
Nature Galeano Niño JL, Wu H et. al.

Nov 18th, 2022 - The tumour-associated microbiota is an intrinsic component of the tumour microenvironment across human cancer types1,2. Intratumoral host-microbiota studies have so far largely relied on bulk tissue analysis1-3, which obscures the spatial distribution and localized effect of the microbiota within tumours. Here, by applying in situ spatial-profiling technologies4 and single-cell RNA sequencing5 ...

Phenotype and Genotype of Adult-onset Adenosine Deaminase 2 Deficiency Patients
Beibei Zu, rongrong wang, Xiaorou Wang et. al.

Nov 14th, 2022 - Background/Purpose: Deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive autoinflammatory disease, characterized by early‑onset vasculopathy, fever, strokes, livedoid rash, hepatosplenomegaly, and hematologic dysfunction, associated with mutations in the ADA2 gene, which was first described in 2014, DADA2 is usually reported in pediatric patients, with 77% before the age of 10 ...

Association Between Anti-Sjögren Syndrome/Scleroderma Autoantigen 1 (SSSCA1) Antibodies and Cancer in Systemic Sclerosis
Rachel Wallwork, Livia Casciola-Rosen1 and Ami Shah, Johns Hopkins University et. al.

Nov 14th, 2022 - Background/Purpose: We sought to examine the association between anti-Sjögren syndrome/scleroderma autoantigen 1 (SSSCA1) antibody and cancer in systemic sclerosis (SSc). We also describe the frequency of anti-SSSCA1 antibody positivity and associated clinical phenotype in patients with SSc. Methods: We conducted a case-control study using data from 210 patients with SSc and cancer, and 205 SS...

Immune Responses to mRNA Vaccines Against SARS-CoV-2 in Patients with Immune-mediated Inflammatory Rheumatic Diseases
Cristiana Sieiro Santos, Sara Calleja Antolín, Clara Moriano Morales et. al.

Nov 14th, 2022 - Background/Purpose: Patients with immune-mediated rheumatic diseases (IMRDs) are commonly treated with immunosuppressors and prone to infections. Recently introduced mRNA SARS-CoV-2 vaccines have demonstrated extraordinary efficacy across all ages. Immunosuppressed patients were excluded from phase III trials with SARS-CoV-2 mRNA vaccines. We aim to fully characterise B-cell and T-cell immune r...

Effects of Excess IL-18 in Mixed Inflammatory Environments
Vinh Dang, Jemy Varghese, Emily Landy et. al.

Nov 14th, 2022 - Background/Purpose: Interleukin 18 (IL-18) is an inflammasome-activated, IL-1 family cytokine that canonically induces interferongamma (IFNg). IL-18 activity is potently inhibited by a soluble, IFNg-inducible antagonist, IL-18 Binding Protein (IL-18BP). IFNg appears central to the pathogenesis of rare, hyperinflammatory states like Hemophagocytic Lymphohistiocytosis (HLH) and Macrophage Activat...

IL-23 Signaling Induces Autoimmune Disease Genes in Mucosal-Associated Invariant T Cells
Tharshana Stephen, Ambre Dangien, Claire Leloup et. al.

Nov 14th, 2022 - Background/Purpose: Genome-wide association studies and mouse models of autoimmune disease have demonstrated an important role of the IL-23 signaling pathway in the pathogenesis of axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), psoriasis (Pso), and Crohn’s disease (CD). This notion has been validated in the clinics by the successful treatment of Pso, PsA, and CD with IL-23 blockers...

The ERβ Agonist, WT-IV-012, Suppresses the Inflammatory Response in Systemic Lupus Erythematosus
Shane Bruckner, Braden Zeno, William Willis et. al.

Nov 14th, 2022 - Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ damage, mainly affecting young women between the ages of 15 and 45 years at a 9:1 rate as compared to men. The etiology of SLE is complex and remains elusive, however the susceptibility of women during the years in which estrogen levels are at their highest may suggest a significant a...

Novel Human Class II MHC Tetramers Detect Rare, Self-Reactive CD4+ T Cells Relevant to Mixed Connective Tissue Disease
Shawn Mahmud, Thamotharampillai Dileepan, Bryce Binstadt and Marc Jenkins et. al.

Nov 14th, 2022 - Background/Purpose: Nearly all patients with mixed connective tissue disease (MCTD) have IgG autoantibodies (autoAb) specific for U170k, a component of the U1-snNRP spliceosomal complex. A genetic link to the MHC II molecule HLA-DRB1*0401 (DR4) and formation of IgG autoAb strongly suggest the importance of CD4+ T cells in MCTD pathogenesis. Defining specific, self-reactive CD4+ T cell populatio...

Parenchymal INFγ Response Regulates Murine Lupus Nephritis
Minjung Kim, Anthony Marinov, Mark Shlomchik2 and Jeremy Tilstra et. al.

Nov 14th, 2022 - Background/Purpose: Lupus nephritis is the most common life-threatening end-organ complication of SLE. Interstitial infiltrates, specifically T cells, are major predictors of disease outcomes. We recently determined that kidney-infiltrating T cells (KITs) are suppressed after kidney infiltration and exhibit an exhausted phenotype. Notably, the kidneys of nephritic lupus-prone (MRL.Faslpr) mice ...

Deficiency of IL-23 Receptor in Podocytes of MRL/lpr lupus-prone Mice Abrogates the Development of Lupus Nephritis Despite IgG Deposition in the Glomeruli
Afroditi Boulougoura, Hao Li, Rhea Bhargava et. al.

Nov 14th, 2022 - Background/Purpose: Interleukin 23 (IL-23) is involved in the pathogenesis of systemic lupus erythematosus (SLE). IL-23 is elevated in the sera of patients with active SLE compared to those with inactive disease and it induces the expansion of pathogenic IL-17-producing cells which infiltrate inflamed tissues including the kidneys. However, there are still limited data on the role of IL-23 on n...

Stability of Cell Bound Complement Activation Products (CB-CAPs), Multianalyte Assay Panel (MAP) with Algorithm, and Other Autoimmune Biomarkers Among Clinical Patients Throughout the SARS-CoV-2 Pa...
Mark Rudolph, Rory Bloch, Anja Kammesheidt and Roberta Alexander et. al.

Nov 14th, 2022 - Background/Purpose: COVID-19 can cause autoantibody signatures in severely ill patients, and widespread emerging post-acute sequelae of SARS-CoV-2 (PASC) share many symptoms consistent with rheumatologic involvement (medRxiv 2021.09.21.21263845). Any impact on diagnosis or monitoring of rheumatological diseases has yet to be determined with a retrospective review of clinical laboratory results....

Different Humoral but Similar Cellular Responses of Patients with Autoimmune Inflammatory Rheumatic Diseases Under Disease-modifying Anti-rheumatic Drugs After COVID-19 Vaccination
Ioana Andreica, Arturo Blazquez-Navarro, Jan Sokolar et. al.

Nov 14th, 2022 - Background/Purpose: The interplay between humoral and cellular response after vaccination against SARS-CoV-2 in patients (pts.) with autoimmune inflammatory rheumatic diseases (AIRD) remains unknown. To investigate the impact of different immunosuppressive therapies on the development of humoral and cellular immune responses to full 2-dose SARS-CoV-2 vaccination in AIRD pts. with stable low dis...

Impaired Dynamic X-Chromosome Inactivation Maintenance in T Lymphocytes Is a Feature of Spontaneous Lupus in Female Mice and Is Exacerbated in Female-Biased Disease Models
Nikhil Jiwrajka, Natalie Toothacre, Zachary Beethem et. al.

Nov 14th, 2022 - Background/Purpose: SLE is highly female-biased, yet the molecular origins of this bias remain unclear. The X chromosome contains many immune-related genes, suggesting that X-linked epigenetic dysregulation may contribute to female-biased immune responses. X-Chromosome Inactivation (XCI) is an X-chromosome-specific epigenetic regulatory mechanism that equalizes X-linked gene dosage between XX f...

Priority Research Topics for Vaccine Uptake Among Adults with Autoimmune Conditions
Shilpa Venkatachalam, William Benjamin Nowell, Shubhasree Banerjee et. al.

Nov 14th, 2022 - Background/Purpose: Compared to the general population, adults living with autoimmune disease are at nearly twice the risk of vaccine-preventable infections, making this a high priority vaccination group. The objective of this study was to prioritize topics for future patient-centered research to reduce vaccine hesitancy and increase uptake of vaccines for conditions such as pneumococcal pneumo...

Platelet-selectin Prime Lupus Neutrophils to Produce Mitochondrial ROS and Participate in SLE Pathogenesis
Marc Scherlinger, Pierre Vacher, Vivien Guillotin et. al.

Nov 14th, 2022 - Background/Purpose: In patients with active systemic lupus erythematosus (SLE), circulating platelets have an activated phenotype characterized by the expression of P-selectin (CD62P). We have shown that in human SLE, platelets interact with T regulatory cells and repress their immunosuppressive functions through a P-selectin/CD15s-dependent interaction (1). We sought to investigate for other p...

Plasmacytoid Dendritic Cells Are Not Major Producers of Type 1 Interferons in Cutaneous Lupus
Thomas Vazquez, Nilesh Kodali, DeAnna Diaz et. al.

Nov 14th, 2022 - Background/Purpose: Type 1 interferons (IFN-1) are major drivers of disease activity in systemic (SLE) and cutaneous lupus erythematosus (CLE). Plasmacytoid dendritic cells (pDCs) are the major producers of IFN-1 during viral infection. Therefore, pDCs have been hypothesized to be the primary IFN-1 producing cell in lupus. IFN-1 production by pDCs has not been extensively studied due to relianc...

Pre-exposure Prophylaxis for SARS-CoV-2 with Subcutaneous Casirivimab/Imdevimab in Vaccine-refractory Patients with Immune-mediated Inflammatory Diseases
Filippo Fagni, Katja Schmidt, Daniela Bohr et. al.

Nov 14th, 2022 - Background/Purpose: Humoral responses to SARS-CoV-2 vaccination are reduced in patients with immune-mediated inflammatory diseases (IMID), especially when treated with B-cell depletion therapies, leading to increased likelihood of severe COVID-19 infection (1,2). A pre-exposure prophylaxis (PrEP) with monoclonal antibodies against SARS-CoV-2 has been shown to efficiently prevent symptomatic COV...

Cellular and Humoral Responses Following SARS-CoV-2 mRNA Vaccination in Patients on PD-1 Immunotherapy with irAEs
Sokratis Apostolidis, Paulina Coutifaris, Mark Painter et. al.

Nov 14th, 2022 - Background/Purpose: Patients with cancer exhibit increased mortality from SARS-CoV-2 infection compared to the general population. SARS-CoV-2 mRNA vaccination in healthy individuals generates effective and long-lasting immune protection against COVID-19. PD-1 is highly expressed on the surface of T follicular helper cells that play a central role in T cell dependent B cell vaccine responses. He...