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About 141,618 results

Efficacy of dietary interventions for inducing histologic remission in patients with eo...
https://doi.org/10.1053/j.gastro.2014.02.006
Gastroenterology Arias A, González-Cervera J et. al.

Feb 18th, 2014 - Various dietary interventions have been used to treat patients with eosinophilic esophagitis (EoE), yielding varied results. This systematic review assesses the efficacy of different dietary therapies in inducing disease remission. We performed a systematic search of the MEDLINE, EMBASE, and SCOPUS databases for studies investigating the efficacy of dietary interventions (reducing infiltration ...

Omalizumab therapy for bullous pemphigoid.
https://doi.org/10.1016/j.jaad.2014.04.053
Journal of the American Academy of Dermatology; Yu KK, Crew AB et. al.

Jun 23rd, 2014 - Bullous pemphigoid (BP) responds to a variety of immunosuppressive agents and usually controls, but does not cure, the disease. Omalizumab, Food and Drug Administration-approved for asthma, selectively suppresses the activity of IgE, an important immunoglobulin in the pathogenesis of BP. We wished to determine if systemic omalizumab would have a therapeutic effect in patients with BP. We treate...

Clinical picture and treatment of 2212 patients with common variable immunodeficiency.
https://doi.org/10.1016/j.jaci.2013.12.1077
The Journal of Allergy and Clinical Immunology; Gathmann B, Mahlaoui N et. al.

Mar 3rd, 2014 - Common variable immunodeficiency (CVID) is an antibody deficiency with an equal sex distribution and a high variability in clinical presentation. The main features include respiratory tract infections and their associated complications, enteropathy, autoimmunity, and lymphoproliferative disorders. This study analyzes the clinical presentation, association between clinical features, and differen...

Transplantation outcomes for severe combined immunodeficiency, 2000-2009.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183064
The New England Journal of Medicine; Pai SY, Logan BR et. al.

Jul 30th, 2014 - The Primary Immune Deficiency Treatment Consortium was formed to analyze the results of hematopoietic-cell transplantation in children with severe combined immunodeficiency (SCID) and other primary immunodeficiencies. Factors associated with a good transplantation outcome need to be identified in order to design safer and more effective curative therapy, particularly for children with SCID diag...

Comparative analysis of rosacea and cutaneous lupus erythematosus: histopathologic feat...
https://doi.org/10.1016/j.jaad.2014.01.892
Journal of the American Academy of Dermatology; Brown TT, Choi EY et. al.

Mar 24th, 2014 - Distinction of rosacea and cutaneous lupus erythematosus (LE) can be challenging because of significant clinical and histologic overlap. A controlled study comparing these conditions is lacking. We compared the histologic features, T-cell subsets, and plasmacytoid dendritic cells in rosacea and LE. Biopsy specimens of rosacea (n = 27) and facial LE (n = 30) were retrospectively reviewed and rea...

Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a...
https://doi.org/10.1016/S0140-6736(14)61185-5
Lancet (London, England); Chang LJ, Dowd KA et. al.

Aug 18th, 2014 - Chikungunya virus--a mosquito-borne alphavirus--is endemic in Africa and south and southeast Asia and has recently emerged in the Caribbean. No drugs or vaccines are available for treatment or prevention. We aimed to assess the safety, tolerability, and immunogenicity of a new candidate vaccine. VRC 311 was a phase 1, dose-escalation, open-label clinical trial of a virus-like particle (VLP) chi...

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362521
Nature Medicine; Xing L, Dai Z et. al.

Aug 18th, 2014 - Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in AA are not defined limiting clinical development of rational targeted therapies. Genome-wide association studies (GWAS) implicated ligands for the NKG2D receptor (product of the KLRK1 gene) in disease pathogenesis. Here, we...

Chimeric antigen receptor T cells for sustained remissions in leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267531
The New England Journal of Medicine; Maude SL, Frey N et. al.

Oct 15th, 2014 - Relapsed acute lymphoblastic leukemia (ALL) is difficult to treat despite the availability of aggressive therapies. Chimeric antigen receptor-modified T cells targeting CD19 may overcome many limitations of conventional therapies and induce remission in patients with refractory disease. We infused autologous T cells transduced with a CD19-directed chimeric antigen receptor (CTL019) lentiviral v...

Eosinophilic esophagitis in adults is associated with IgG4 and not mediated by IgE.
https://doi.org/10.1053/j.gastro.2014.05.036
Gastroenterology Clayton F, Fang JC et. al.

Jun 7th, 2014 - Eosinophilic esophagitis is usually triggered by foods, by unclear mechanisms. We evaluated the roles of IgE and IgG4 in the development of eosinophilic esophagitis. We performed a prospective, randomized, double-blind, placebo-controlled trial of adults with eosinophilic esophagitis given an antibody against IgE (omalizumab, n = 16) or placebo (n = 14) every 2-4 weeks for 16 weeks, based on we...

Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associate...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455597
Journal of Clinical Oncology : Official Journal of the Am... Kochenderfer JN, Somerville RPT et. al.

Mar 15th, 2017 - Purpose T cells genetically modified to express chimeric antigen receptors (CARs) targeting CD19 (CAR-19) have potent activity against acute lymphoblastic leukemia, but fewer results supporting treatment of lymphoma with CAR-19 T cells have been published. Patients with lymphoma that is chemotherapy refractory or relapsed after autologous stem-cell transplantation have a grim prognosis, and new...

A Cluster of CNS Infections Due to B. cereus in the Setting of Acute Myeloid Leukemia: ...
https://doi.org/10.1097/NEN.0000000000000244
Journal of Neuropathology and Experimental Neurology; Vodopivec I, Rinehart EM et. al.

Sep 9th, 2015 - Bacillus cereus typically causes a self-limited foodborne gastrointestinal (GI) illness. Severe invasive infection occurs rarely, mainly among immunocompromised hosts. We describe a cluster of B. cereus infections among 5 patients with acute myeloid leukemia and chemotherapy-induced neutropenia. The initial case presented with occipital lobe abscess and was found on biopsy to have organisms con...

Haploinsufficiency of TNFAIP3 (A20) by germline mutation is involved in autoimmune lymp...
https://doi.org/10.1016/j.jaci.2016.09.038
The Journal of Allergy and Clinical Immunology; Takagi M, Ogata S et. al.

Nov 15th, 2016 - Autoimmune diseases in children are rare and can be difficult to diagnose. Autoimmune lymphoproliferative syndrome (ALPS) is a well-characterized pediatric autoimmune disease caused by mutations in genes associated with the FAS-dependent apoptosis pathway. In addition, various genetic alterations are associated with the ALPS-like phenotype. The aim of the present study was to elucidate the gene...

Multiple sclerosis and the major histocompatibility complex.
https://doi.org/10.1097/WCO.0b013e32832b5417
Current Opinion in Neurology; Ramagopalan SV, Knight JC et. al.

Apr 23rd, 2009 - Multiple sclerosis (MS) is the most common neurological disease affecting young adults. The cause is unknown, but detailed epidemiological and genetic studies have shown a clear inherited component. We review here some of the recent findings of MS genetics with a particular focus on genes of the major histocompatibility complex (MHC). Recent studies add further complexity to the role of the MHC...

Thinking in three dimensions: a web-based algorithm to aid the interpretation of tuberc...
https://www.ncbi.nlm.nih.gov/pubmed/18419884
The International Journal of Tuberculosis and Lung Diseas... Menzies D, Gardiner G et. al.

Apr 18th, 2008 - The tuberculin skin test (TST) is the most widely used test for detecting tuberculosis (TB) infection. Accurate interpretation of TST requires consideration of three dimensions-the size of the skin reaction, the positive predictive value (PPV) and risk of disease. We developed a web-based algorithm incorporating epidemiological, medical and radiographic risk factors to help in the interpretatio...

Chemokines in the pathogenesis of lichenoid tissue reactions.
https://doi.org/10.1038/jid.2008.251
The Journal of Investigative Dermatology; Meller S, Gilliet M et. al.

Aug 22nd, 2008 - Clinical manifestations of lichenoid tissue reactions are heterogenous and include the cutaneous lupus erythematosus and lichen planus. Lichenoid tissue reactions are characterized by epidermal basal-cell damage and a variable subepithelial inflammatory infiltrate including cytotoxic T(H)1 cells and plasmacytoid dendritic cells. Here, we summarize the current knowledge of the role of chemokines...

Update on rapid diagnostic testing for malaria.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223842
Clinical Microbiology Reviews; Murray CK, Gasser RA et. al.

Jan 18th, 2008 - To help mitigate the expanding global impact of malaria, with its associated increasing drug resistance, implementation of prompt and accurate diagnosis is needed. Malaria is diagnosed predominantly by using clinical criteria, with microscopy as the current gold standard for detecting parasitemia, even though it is clearly inadequate in many health care settings. Rapid diagnostic tests (RDTs) h...

Catamenial dermatoses: has anyone ever considered prostaglandins?
https://doi.org/10.1111/ced.12333
Clinical and Experimental Dermatology; Verdolini R, Atkar R et. al.

May 1st, 2014 - Catamenial dermatoses are unusual, cyclic, perimenstrual reactions to hormones produced during the menstrual cycle. They occur in a variety of clinical presentations, including urticaria, eczema, fixed drug eruptions, erythema multiforme and anaphylaxis. Autoimmune progesterone dermatitis is the most common, and is caused by an autoimmune response to endogenous progesterone in women of reproduc...

Nocardia infections among immunomodulated inflammatory bowel disease patients: A review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458760
World Journal of Gastroenterology; Abreu C, Rocha-Pereira N et. al.

Jun 15th, 2015 - Human nocardiosis, caused by Nocardia spp., an ubiquitous soil-borne bacteria, is a rare granulomatous disease close related to immune dysfunctions. Clinically can occur as an acute life-threatening disease, with lung, brain and skin being commonly affected. The infection was classically diagnosed in HIV infected persons, organ transplanted recipients and long term corticosteroid treated patien...

An inactivated cell-culture vaccine against yellow fever.
https://doi.org/10.1056/NEJMoa1009303
The New England Journal of Medicine; Monath TP, Fowler E et. al.

Apr 7th, 2011 - Yellow fever is a lethal viral hemorrhagic fever occurring in Africa and South America. A highly effective live vaccine (17D) is widely used for travelers to and residents of areas in which yellow fever is endemic, but the vaccine can cause serious adverse events, including viscerotropic disease, which is associated with a high rate of death. A safer, nonreplicating vaccine is needed. In a doub...

Intrathecal cytokine and chemokine profiling in neuropsychiatric lupus or lupus complic...
https://doi.org/10.1177/0961203309357061
Lupus Lu XY, Zhu CQ et. al.

Feb 24th, 2010 - The aims of this study are to investigate the cytokine, chemokine and adhesion molecule profiles in cerebrospinal fluid from patients with neuropsychiatric systemic lupus erythematosus and systemic lupus erythematosus with central nervous system infection. Experimental sets were established which included 108 patients and 132 cerebrospinal fluid samples. The patients were grouped as neuropsychi...