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About 120,848 results

SARS-CoV-2 Reinfection Rate and Estimated Effectiveness of the Inactivated Whole Virion...
https://doi.org/10.1001/jamanetworkopen.2021.42210
JAMA Network Open; Malhotra S, Mani K et. al.

Jan 8th, 2022 - A surge of COVID-19 occurred from March to June 2021, in New Delhi, India, linked to the B.1.617.2 (Delta) variant of SARS-CoV-2. COVID-19 vaccines were rolled out for health care workers (HCWs) starting in January 2021. To assess the incidence density of reinfection among a cohort of HCWs and estimate the effectiveness of the inactivated whole virion vaccine BBV152 against reinfection. This wa...

Sequential immunization with SARS-CoV-2 RBD vaccine induces potent and broad neutraliza...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724645
Virology Journal; Song S, Zhou B et. al.

Jan 6th, 2022 - The current COVID-19 pandemic caused by constantly emerging SARS-CoV-2 variants still poses a threat to public health worldwide. Effective next-generation vaccines and optimized booster vaccination strategies are urgently needed. Here, we sequentially immunized mice with a SARS-CoV-2 wild-type inactivated vaccine and a heterologous mutant RBD vaccine, and then evaluated their neutralizing antib...

IgG3 and IgM Identified as Key to SARS-CoV-2 Neutralization in Convalescent Plasma Pools.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726489
PloS One; Kober C, Manni S et. al.

Jan 5th, 2022 - Analysis of convalescent plasma derived from individuals has shown that IgG3 has the most important role in binding to SARS-CoV-2 antigens; however, this has not yet been confirmed in large studies, and the link between binding and neutralization has not been confirmed. By analyzing plasma pools consisting of 247-567 individual convalescent donors, we demonstrated the binding of IgG3 and IgM to...

Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711287
Molecular Medicine (Cambridge, Mass.); Chapoval SP, Keegan AD

Dec 29th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is critically important to define the immunological processes occurring in the human response to this virus and pathogenetic mechanisms of its deadly ma...

Systematic characterization of the tumor microenvironment in Chinese patients with hepa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717124
Oncology Reports; Feng Y, Liu L et. al.

Dec 28th, 2021 - Hepatocellular carcinoma (HCC) is an immunogenic malignancy, which exhibits low responsiveness to programmed cell death protein‑1 (PD‑1)/programmed death ligand‑1 (PD‑L1) antibodies. Therefore, the identification of novel immunotherapeutic targets to treat HCC is imperative. Systematic characterization of the HCC tumor microenvironment (TME) can provide novel insight into additional therapeutic...

SARS-CoV-2 spreads through cell-to-cell transmission.
https://doi.org/10.1073/pnas.2111400119
Proceedings of the National Academy of Sciences of the Un... Zeng C, Evans JP et. al.

Dec 24th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible coronavirus responsible for the global COVID-19 pandemic. Herein, we provide evidence that SARS-CoV-2 spreads through cell-cell contact in cultures, mediated by the spike glycoprotein. SARS-CoV-2 spike is more efficient in facilitating cell-to-cell transmission than is SARS-CoV spike, which reflects, in part,...

Children develop robust and sustained cross-reactive spike-specific immune responses to...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709786
Nature Immunology; Dowell AC, Butler MS et. al.

Dec 24th, 2021 - SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for this outcome is unclear. Here we compare antibody and cellular immunity in children (aged 3-11 years) and adults. Antibody responses against spike protein were high in children and seroconversion boosted responses against seasonal Beta-coronaviruses through cross-recognition of the S2 domain. Neutraliz...

Prolonged activation of nasal immune cell populations and development of tissue-residen...
https://doi.org/10.1038/s41590-021-01095-w 10.1038/s41586-020-2588-y 10.1016/j.xcrm.2020.100078 10.1126/science.abc6027 10.1038/s41590-021-01028-7 10.1038/s41591-020-0901-9 10.1038/s41587-020-0602-4 10.1016/j.immuni.2021.03.005 10.1016/j.cell.2021.07.023 10.1038/s41422-020-00455-9 10.1371/journal.pone.0169805 10.1182/blood-2016-04-713206 10.1016/j.immuni.2020.07.026 10.1189/jlb.0408256 10.15252/msb.20178124 10.1146/annurev.immunol.23.021704.115816 10.4049/jimmunol.182.3.1404 10.1016/j.immuni.2018.03.015 10.1016/j.cell.2020.05.015 10.1016/j.immuni.2020.10.006 10.1038/s41590-020-0782-6 10.1038/s41598-018-28791-2 10.1038/nprot.2015.020 10.1002/cyto.a.22826 10.3389/fimmu.2019.02367 10.1038/s41467-021-22811-y 10.4049/jimmunol.165.11.6229 10.1172/JCI86175 10.1038/nmeth.2639
Nature Immunology; Roukens AHE, Pothast CR et. al.

Dec 24th, 2021 - Systemic immune cell dynamics during coronavirus disease 2019 (COVID-19) are extensively documented, but these are less well studied in the (upper) respiratory tract, where severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates1-6. Here, we characterized nasal and systemic immune cells in individuals with COVID-19 who were hospitalized or convalescent and compared the immune ce...

Expansion of invariant natural killer T cells from systemic lupus erythematosus patient...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694473
PloS One; Hsu CY, Chueh YS et. al.

Dec 23rd, 2021 - CD1d-restricted invariant natural killer T cells (iNKT cells) may play an important role in the pathogenesis of systemic lupus erythematosus (SLE). Interleukin (IL)-15 is a pro-inflammatory cytokine which is over-expressed in SLE patients. In the present study, we investigated the iNKT cell expansion of mononuclear cells (MNCs) from SLE patients following 10 days' culture with α-galactosylceram...

The presence of circulating antibody secreting cells and long-lived memory B cell respo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686587
Malaria Journal; Kochayoo P, Sanguansuttikul P et. al.

Dec 22nd, 2021 - Development of an effective vaccine against blood-stage malaria requires the induction of long-term immune responses. Plasmodium vivax Reticulocyte Binding Protein 1a (PvRBP1a) is a blood-stage parasite antigen which is associated with invasion of red blood cells and induces antibody responses. Thus, PvRBP1a is considered as a target for design of a blood-stage vaccine against vivax malaria. Bo...

Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their compl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688474
Nature Communications; Wang Y, Xu C et. al.

Dec 22nd, 2021 - The emergence of SARS-CoV-2 Kappa and Beta variants with enhanced transmissibility and resistance to neutralizing antibodies has created new challenges for the control of the ongoing COVID-19 pandemic. Understanding the structural nature of Kappa and Beta spike (S) proteins and their association with ACE2 is of significant importance. Here we present two cryo-EM structures for each of the Kappa...

Risk surveillance and mitigation: autoantibodies as triggers and inhibitors of severe r...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686808
Molecular Medicine (Cambridge, Mass.); Chen C, Amelia A et. al.

Dec 22nd, 2021 - COVID-19 clinical presentation differs considerably between individuals, ranging from asymptomatic, mild/moderate and severe disease which in some cases are fatal or result in long-term effects. Identifying immune mechanisms behind severe disease development informs screening strategies to predict who are at greater risk of developing life-threatening complications. However, to date clear progn...

De novo and relapsing glomerulonephritis after COVID-19 vaccination: how much do we know?
https://doi.org/10.1111/nep.14013
Nephrology (Carlton, Vic.); Chan ATP, Tang SCW

Dec 22nd, 2021 - De novo and relapsing glomerulonephritis after COVID-19 vaccination: how much do we know?|2021|Chan ATP,Tang SCW,|prevention & control,virology,adverse effects,epidemiology,etiology,immunology,adverse effects,

Roles of IL-35-producing T and B cells in anti-acetylcholine receptor antibody-positive...
https://doi.org/10.1016/j.jocn.2021.11.020
Journal of Clinical Neuroscience : Official Journal of Th... Li LM, Zhang LJ et. al.

Dec 21st, 2021 - Interleukin 35 (IL-35) plays an anti-inflammatory in numerous autoimmune diseases. However, the potential roles of IL-35-producing T and B cells and serum IL-35 levels in the pathogenesis of myasthenia gravis (MG) and its association with disease activity in patients with MG remain unclear. The percentages of IL-35-producing CD4 + CD25 + T cells and CD19 + B cells among peripheral blood mononuc...

Early use of canakinumab to prevent mechanical ventilation in select COVID-19 patients:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725043
International Journal of Immunopathology and Pharmacology; Mastroianni A, Greco S et. al.

Dec 21st, 2021 - The fully-human monoclonal anti-interleukin (IL)-1β antibody canakinumab may inhibit the production of inflammatory mediators in patients with coronavirus disease 2019 (COVID-19) and the hyperinflammatory response potentially leading to acute respiratory distress syndrome. The goal of our retrospective, observational analysis was to evaluate the safety and efficacy of subcutaneous (s.c.) canaki...

Relationship between Antibody Levels and SARS-Cov-2 Reinfection.
https://www.ncbi.nlm.nih.gov/pubmed/34921027
Annals of Clinical and Laboratory Science; Islamoglu MS, Cengiz M et. al.

Dec 19th, 2021 - In this period when mutant strains are increasing all over the world, studies on how much humoral immunity will protect against the Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) are quite limited. The aim of our study is to investigate the positivity and antibody levels of the COVID-19 reverse transcription polymerase chain reaction (RT-PCR) test, the frequency of SARS-CoV-2 re-infection, an...

An integrative bioinformatics analysis for identifying hub genes associated with infect...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677925
European Journal of Medical Research; Xie TA, He ZJ et. al.

Dec 19th, 2021 - At the end of 2019, the world witnessed the emergence and ravages of a viral infection induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Also known as the coronavirus disease 2019 (COVID-19), it has been identified as a public health emergency of international concern (PHEIC) by the World Health Organization (WHO) because of its severity. The gene data of 51 samples were ...

Investigating immune and non-immune cell interactions in head and neck tumors by single...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683505
Nature Communications; Kürten CHL, Kulkarni A et. al.

Dec 19th, 2021 - Head and neck squamous cell carcinoma (HNSCC) is characterized by complex relations between stromal, epithelial, and immune cells within the tumor microenvironment (TME). To enable the development of more efficacious therapies, we aim to study the heterogeneity, signatures of unique cell populations, and cell-cell interactions of non-immune and immune cell populations in 6 human papillomavirus ...

Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squam...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683407
Nature Communications; Dinh HQ, Pan F et. al.

Dec 19th, 2021 - The tumor microenvironment is a highly complex ecosystem of diverse cell types, which shape cancer biology and impact the responsiveness to therapy. Here, we analyze the microenvironment of esophageal squamous cell carcinoma (ESCC) using single-cell transcriptome sequencing in 62,161 cells from blood, adjacent nonmalignant and matched tumor samples from 11 ESCC patients. We uncover heterogeneit...

Humoral and cellular immunity in convalescent COVID-19 people with multiple sclerosis t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667348
Journal of Neuroimmunology; Adamec I, Rogić D et. al.

Dec 19th, 2021 - To report clinical outcome, development of humoral and T-cell mediated immunity in convalescent COVID-19 people with multiple sclerosis (pwMS) treated with ofatumumab in the ALITHIOS study from a single center. Testing for SARS-Cov2 IgG antibodies was performed on two occasions with at least three months apart between the two testing. During the second antibody testing, interferon-γ ELISpot was...