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About 127,480 results

Single-cell analyses highlight the proinflammatory contribution of C1q-high monocytes t...
https://doi.org/10.1073/pnas.2204289119
Proceedings of the National Academy of Sciences of the Un... Zheng W, Wang X et. al.

Jun 22nd, 2022 - Behçet's disease (BD) is a chronic vasculitis characterized by systemic immune aberrations. However, a comprehensive understanding of immune disturbances in BD and how they contribute to BD pathogenesis is lacking. Here, we performed single-cell and bulk RNA sequencing to profile peripheral blood mononuclear cells (PBMCs) and isolated monocytes from BD patients and healthy donors. We observed p...

Acute Disseminated Encephalomyelitis After SARS-CoV-2 Vaccination.
https://doi.org/10.12659/AJCR.936574
The American Journal of Case Reports; Ahmad HR, Timmermans VM et. al.

Jun 20th, 2022 - BACKGROUND Acute disseminated encephalomyelitis (ADEM) is a disorder of the central nervous system which has been associated with preceding infection as well as vaccinations. We present a case of a 61-year-old woman with ADEM after receiving her initial vaccination for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This case highlights management of this acute condition. CASE...

Urine Test Detects SARS-CoV-2 Antibodies.
https://doi.org/10.1001/jama.2022.9512
JAMA Larkin HD

Jun 15th, 2022 - Urine Test Detects SARS-CoV-2 Antibodies.|2022|Larkin HD,|urine,diagnosis,immunology,urine,methods,immunology,methods,

Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity again...
https://doi.org/10.1073/pnas.2122379119
Proceedings of the National Academy of Sciences of the Un... Dong H, Ham JD et. al.

Jun 14th, 2022 - Acute myeloid leukemia (AML) remains a therapeutic challenge, and a paucity of tumor-specific targets has significantly hampered the development of effective immune-based therapies. Recent paradigm-changing studies have shown that natural killer (NK) cells exhibit innate memory upon brief activation with IL-12 and IL-18, leading to cytokine-induced memory-like (CIML) NK cell differentiation. CI...

Expansion of cytotoxic tissue-resident CD8+ T cells and CCR6+CD161+ CD4+ T cells in the...
https://doi.org/10.1038/s41467-022-30913-4 10.1002/cti2.1242 10.1038/s41467-021-23333-3 10.1056/NEJMoa2034577 10.1038/s41586-020-2598-9 10.1016/j.cell.2020.05.015 10.1126/science.abd3871 10.1038/s41586-020-2550-z 10.1038/s41586-020-03041-6 10.1371/journal.pone.0245532 10.3389/fimmu.2020.610300 10.1038/ni.2744 10.4049/jimmunol.1200402 10.1016/j.celrep.2017.08.078 10.4049/jimmunol.1101836 10.1038/mi.2015.51 10.1016/j.immuni.2008.02.020 10.1038/d41586-021-01396-y 10.1084/jem.20090858 10.1038/nri3442 10.1126/sciimmunol.aar4526 10.1038/s41422-020-00455-9 10.1038/s41586-020-03148-w 10.1016/j.immuni.2020.12.009 10.1038/s41577-020-00460-4 10.1126/sciimmunol.abk0894 10.1038/s41590-021-01095-w 10.1126/sciimmunol.abl9105 10.1038/s41385-019-0218-5 10.1038/s41385-018-0080-x 10.1038/s41467-021-27063-4 10.1016/j.cell.2022.02.005 10.1126/sciimmunol.abj5129 10.1016/j.ebiom.2021.103762 10.1002/cyto.a.21015
Nature Communications; Ssemaganda A, Nguyen HM et. al.

Jun 11th, 2022 - Vaccines against SARS-CoV-2 have shown high efficacy in clinical trials, yet a full immunologic characterization of these vaccines, particularly within the human upper respiratory tract, is less well known. Here, we enumerate and phenotype T cells in nasal mucosa and blood using flow cytometry before and after vaccination with the Pfizer-BioNTech COVID-19 vaccine (n = 21). Tissue-resident memor...

Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory...
https://doi.org/10.1073/pnas.2202069119
Proceedings of the National Academy of Sciences of the Un... Americo JL, Cotter CA et. al.

Jun 10th, 2022 - Current vaccines have greatly diminished the severity of the COVID-19 pandemic, even though they do not entirely prevent infection and transmission, likely due to insufficient immunity in the upper respiratory tract. Here, we compare intramuscular and intranasal administration of a live, replication-deficient modified vaccinia virus Ankara (MVA)-based Severe Acute Respiratory Syndrome Coronavir...

Comprehensive analysis of the importance of PLAUR in the progression and immune microen...
https://doi.org/10.1371/journal.pone.0269595
PloS One; Wang Z, Wang K et. al.

Jun 9th, 2022 - Clear cell renal cell carcinoma (ccRCC) is a common type of kidney cancer with a high mortality rate, and the discovery of new therapeutic markers is essential to improve patient survival. The plasminogen activator urokinase receptor (PLAUR) plays key roles in tissue remodeling and extracellular matrix degradation, which contribute to invasion and metastasis, a major feature of tumor malignancy...

Semaphorin 4B promotes tumor progression and associates with immune infiltrates in lung...
https://doi.org/10.1186/s12885-022-09696-w 10.3322/caac.21654 10.1016/S0140-6736(16)30958-8 10.6004/jnccn.2018.0062 10.1158/0008-5472.CAN-18-1281 10.3390/jcm9051362 10.1146/annurev-pathol-042020-042741 10.1016/S0092-8674(00)80063-X 10.1038/embor.2008.139 10.1038/onc.2013.474 10.1038/nri1003 10.1038/nature01037 10.1038/onc.2014.79 10.1016/j.cytogfr.2020.05.006 10.1158/2326-6066.CIR-18-0156 10.1158/1541-7786.MCR-18-0933 10.1111/imm.13189 10.3389/fonc.2021.731896 10.3389/fmolb.2021.679031 10.21037/atm.2020.04.38 10.1016/j.urolonc.2018.07.019 10.1038/nbt.3772 10.1093/nar/gkaa407 10.1089/omi.2011.0118 10.1111/1759-7714.13370 10.3892/ol.2021.13063 10.1111/cas.13722 10.1038/s41598-017-18551-z 10.1038/sj.onc.1210183 10.1016/j.ccr.2008.10.011 10.3390/vaccines4040036 10.1111/febs.15361 10.1016/j.semcancer.2019.12.019 10.1016/j.cellsig.2015.02.027 10.1007/s13277-014-1651-4 10.1007/s13277-014-2409-8 10.1186/s13059-014-0550-8 10.1093/nar/gkaa970 10.1093/nar/28.1.27 10.1002/pro.3715 10.1093/bioinformatics/btv300 10.1186/1471-2105-14-7
BMC Cancer; Jiang J, Lu Y et. al.

Jun 9th, 2022 - Semaphorins have been found to play important roles in multiple malignancy-related processes. However, the role of Semaphorin 4B (SEMA4B) in lung cancer remains unclear. Here, we aimed to explore the biological functions of SEMA4B in through bioinformatic analysis, in vitro and in vivo assays. In the present study, the possible mechanism by which SEMA4B affected the tumor growth and microenviro...

Myeloid caspase-8 restricts RIPK3-dependent proinflammatory IL-1β production and CD4 T ...
https://doi.org/10.1073/pnas.2117636119
Proceedings of the National Academy of Sciences of the Un... Kim S, Lu HC et. al.

Jun 8th, 2022 - Caspase-8 functions at the crossroad of programmed cell death and inflammation. Here, using genetic approaches and the experimental autoimmune encephalomyelitis model of inflammatory demyelination, we identified a negative regulatory pathway for caspase-8 in infiltrated macrophages whereby it functions to restrain interleukin (IL)-1β-driven autoimmune inflammation. Caspase-8 is partially activa...

Crohn's Disease Biomarker Appears Years Ahead of Diagnosis
https://www.medscape.com/viewarticle/975081

Jun 6th, 2022 - Anti–granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies predict complicated Crohn's disease (CD) years before signs or symptoms of the disease appear, according to new data. A study of records from active military personnel indicates that this novel biomarker holds promise for the diagnosis, management, and treatment of complicated CD. "To the best of my knowledge, this is...

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interact...
https://doi.org/10.1128/jvi.00412-22
Journal of Virology; Liu H, Bai Y et. al.

Jun 3rd, 2022 - SARS-CoV-2 is the causative agent of the ongoing pandemic of coronavirus disease 2019 (COVID-19) and poses a significant threat to global health. N protein (NP), which is a major pathogenic protein among betacoronaviruses, binds to the viral RNA genome to allow viral genome packaging and viral particle release. Recent studies showed that NP antagonizes interferon (IFN) induction and mediates ph...

Audio Interview: Dissecting the Host Response to SARS-CoV-2.
https://doi.org/10.1056/NEJMe2207246
The New England Journal of Medicine; Rubin EJ, Baden LR et. al.

Jun 2nd, 2022 - Audio Interview: Dissecting the Host Response to SARS-CoV-2.|2022|Rubin EJ,Baden LR,Moore PL,Morrissey S,|immunology,virology,immunology,

ncRNA-Mediated High Expression of LPCAT1 Correlates with Poor Prognosis and Tumor Immun...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126685
Journal of Immunology Research; Sun Q, Liu X et. al.

May 27th, 2022 - To investigate the expression of LPCAT1 in liver hepatocellular carcinoma (LIHC) and its relationship with prognosis and immune infiltration and predict its upstream nonencoding RNAs (ncRNAs). In this study, expression analysis and survival analysis for LPCAT1 in pan cancers were first performed by using The Cancer Genome Atlas (TCGA) data, which suggested that LPCAT1 might be a potential LIHC ...

Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2.
https://doi.org/10.1056/NEJMoa2118946
The New England Journal of Medicine; Goldberg Y, Mandel M et. al.

May 26th, 2022 - Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provides natural immunity against reinfection. Recent studies have shown waning of the immunity provided by the BNT162b2 vaccine. The time course of natural and hybrid immunity is unknown. Using the Israeli Ministry of Health database, we extracted data for August and September 2021, when the B.1.617.2 (delta) variant w...

Biological and Immune Responses to Current Anti-SARS-CoV-2 mRNA Vaccines beyond Anti-Sp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124111
Journal of Immunology Research; Federico M

May 25th, 2022 - Several vaccine strategies are now available to fight the current SARS-CoV-2 pandemic. Those based on the administration of lipid-complexed messenger(m)RNA molecules represent the last frontiers in terms of technology innovation. mRNA molecules coding for the SARS-CoV-2 Spike protein are intramuscularly injected, thereby entering cells by virtue of their encapsulation into synthetic lipid nanov...

MTDH antisense oligonucleotides reshape the immunosuppressive tumor microenvironment to...
https://doi.org/10.1016/j.canlet.2022.215750
Cancer Letters; Wan JL, Wang B et. al.

May 25th, 2022 - Immune checkpoint blockade (ICB) therapy is an important treatment option for individuals with cancer, but it has certain limitations. Identifying a better target that can overcome tumor immune escape and stimulate T cell activity is critical. This research aimed to delve into the molecular mechanism underlying the immunoregulatory function of metadherin (MTDH), which is a novel and potential t...

A Prognosis Marker Dynein Cytoplasmic 1 Heavy Chain 1 Correlates with EMT and Immune Si...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117040
Disease Markers; Wang Y, Han J et. al.

May 24th, 2022 - Liver hepatocellular carcinoma (LIHC) has had a continuous increase in incidence and mortality rates over the last 40 years. Dynein Cytoplasmic 1 Heavy Chain 1 (DYNC1H1) is a protein coding gene which encodes the cytoplasmic dynein heavy chain family. This is the first investigation into the expression of DYNC1H1 and its mechanisms of action in LIHC patients. Based on the DYNC1H1 expression dat...

Characterization of a novel microfilarial antigen for diagnosis of Wuchereria bancrofti...
https://doi.org/10.1371/journal.pntd.0010407
PLoS Neglected Tropical Diseases; Greene SE, Fischer K et. al.

May 24th, 2022 - Lymphatic filariasis (LF) is a neglected tropical disease caused by the filarial nematodes Wuchereria bancrofti, Brugia malayi and Brugia timori. The Global Program to Eliminate LF uses mass drug administration (MDA) of anti-filarial drugs that clear microfilariae (Mf) from blood to interrupt transmission by mosquitos. New diagnostic tools are needed to assess the impact of MDA on bancroftian f...

The future of cancer immunotherapy for brain tumors: a collaborative workshop.
https://doi.org/10.1186/s12967-022-03438-z 10.1093/neuonc/noaa277 10.1158/1078-0432.CCR-20-1135 10.1038/s41591-018-0337-7 10.1186/s13059-017-1362-4 10.1038/s41591-018-0337-7 10.1038/s41467-021-24293-4 10.1016/j.cell.2018.08.039 10.1126/sciadv.aax5851 10.1016/j.ymthe.2017.10.002 10.1158/1078-0432.CCR-17-2041 10.1038/s41591-020-0821-8 10.1056/NEJMoa1610497 10.1101/2021.09.22.460392 10.1001/jamaoncol.2020.4508 10.1126/scitranslmed.aaw2672 10.1158/2159-8290.CD-20-1661 10.1038/s41591-018-0006-x 10.1158/2326-6066.CIR-15-0230 10.1126/scitranslmed.aaa0984 10.1126/scitranslmed.abe7378 10.1016/S1470-2045(17)30517-X 10.1038/s41586-018-0810-y 10.1172/JCI140378 10.1172/JCI151239 10.1007/978-1-0716-0327-7_10 10.1016/bs.pmbts.2019.06.016 10.1016/j.cell.2020.09.015 10.1200/JCO.2017.75.8219 10.1093/neuonc/noaa215.989 10.1038/s41467-020-20469-6 10.1158/1078-0432.CCR-20-3805 10.1038/s42003-018-0163-y 10.1093/neuonc/noaa066 10.1016/j.jcyt.2020.01.014
Journal of Translational Medicine; Brown CE, Bucktrout S et. al.

May 24th, 2022 - Harnessing the effector mechanisms of the immune system to combat brain tumors with antigen specificity and memory has been in research and clinical testing for many years. Government grant mechanisms and non-profit organizations have supported many innovative projects and trials while biotech companies have invested in the development of needed tools, assays and novel clinical approaches. The ...

Immunoinformatic paradigm predicts macrophage and T-cells epitope responses against glo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108098
International Immunopharmacology; Maiti S, Banerjee A et. al.

May 22nd, 2022 - Different quickly-developed vaccines are introduced against COVID-19 with inconclusive results especially against some recent variants. Eventually, somewhere COVID-19 cases decline and in some countries it revived with some new mutant-variants (i.e. D614G, Delta and Omicron). Proposing a universal vaccination strategy by screening globally-conserved SARS-CoV-2 spike-epitopes. Presently, several...