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Concomitant disease should be considered when treating progressive glaucoma
https://www.healio.com/news/ophthalmology/20220120/concomitant-disease-should-be-considered-when-treating-progressive-glaucoma

Jan 20th, 2022 - WAIKOLOA, Hawaii — Ophthalmologists should consider co-management of other diseases when treating progressive glaucoma, according to a speaker here. “I think that we need to remind ourselves, even as we rush through clinic, to think about the linkage to common disease that puts the optic nerve at risk,” Jeffrey L. Goldberg, MD, PhD, said at Hawaiian Eye 2022. To aid with co-management, he said,...

Chang highlights new trends in antibiotic prophylaxis for endophthalmitis
https://www.healio.com/news/ophthalmology/20220118/chang-highlights-new-trends-in-antibiotic-prophylaxis-for-endophthalmitis

Jan 18th, 2022 - WAIKOLOA, Hawaii — Just past the 15-year anniversary of the cefuroxime ESCRS trial, debate regarding antibiotic prophylaxis for endophthalmitis after cataract surgery continues. “When you have something controversial, it's nice to see what our colleagues are doing,” David F. Chang, MD, said at Hawaiian Eye 2022. To that end, surveys of ASCRS members conducted in 2007, 2014 and 2021 published in...

How to avoid the perils of uveitis diagnostic management
https://www.healio.com/news/ophthalmology/20220116/how-to-avoid-the-perils-of-uveitis-diagnostic-management

Jan 16th, 2022 - WAIKOLOA, Hawaii — It is important for physicians to consider “the perils that dwell” in the diagnostic management of patients with uveitis, Steven Yeh, MD, said during a presentation at Hawaiian Eye 2022. “With these patients being very complex oftentimes, we really just don’t want to miss something,” Yeh said. To better identify “the pearls amongst the perils” in uveitis diagnosis, it is impo...

Natural History and Development of Spondyloarthritis
https://clinicaltrials.gov/ct2/show/NCT01422694

Oct 14th, 2022 - The purpose of this protocol is to study the natural history of spondyloarthritis (SpA) in children and adults. Spondyloarthritis encompasses a spectrum of immune-mediated inflammatory diseases that exhibit overlapping features, but differ from other types of inflammatory arthritis in genetic predisposition, pathogenesis, and outcome. Ankylosing spondylitis (AS), the most common form of SpA, fr...

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
https://doi.org/10.1002/art.41752
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

2019 Update of the American College of Rheumatology/Spondylitis Association of America/...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764882
Arthritis & Rheumatology (Hoboken, N.J.); Ward MM, Deodhar A et. al.

Aug 23rd, 2019 - To update evidence-based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA). We conducted updated systematic literature reviews for 20 clinical questions on pharmacologic treatment addressed in the 2015 guidelines, and for 26 new questions on pharmacologic treatment, treat-to-target strategy, and use of imaging. New q...

Prevalence and Factors Associated With Antigen Test Positivity Following SARS-CoV-2 Infection Among Health Care Workers in Los Angeles
https://academic.oup.com/ofid/article/9/10/ofac462/6762879
Open Forum Infectious Diseases; Adamson PC, .

Oct 19th, 2022 - Surges of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among health care workers (HCWs) have led to critical staffing shortages. From January 4 to February 4, 2022, we implemented a return-to-work antigen testing program for HCWs, and 870 HCWs participated. Antigen test positivity was 60.5% for those ≤5 days from symptom onset or positive polymerase chain reaction (PC...

Fluconazole - fluconazole tablet-REMEDYREPACK INC.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d11e0926-cd15-49ba-b0ee-2b6d4e009dd8

Dec 30th, 2022 - Fluconazole tablets are indicated for the treatment of: Vaginal candidiasis (vaginal yeast infections due to Candida). Oropharyngeal and esophageal candidiasis. In open noncomparative studies of relatively small numbers of patients, fluconazole tablets were also effective for the treatment of Candida urinary tract infections, peritonitis, and systemic Candida infections including candidemia, di...

Rebound of SARS-CoV-2 Infection after Nirmatrelvir–Ritonavir Treatment
https://www.nejm.org/doi/full/10.1056/NEJMc2206449
The New England Journal of Medicine; Charness ME, .

Sep 15th, 2022 - Nirmatrelvir is an inhibitor of the main protease in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has been shown to block viral replication and reduce disease severity in unvaccinated persons at risk for the progression of coronavirus disease 2019 (Covid-19).1 Here, we describe the occurrence of rebound symptoms and viral replication after treatment with nirmatrelvir combin...

Associations of Depression, Anxiety, Worry, Perceived Stress, and Loneliness Prior to Infection With Risk of Post–COVID-19 Conditions
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2796097
JAMA Psychiatry; Wang S, Quan L et. al.

Sep 7th, 2022 - Postacute sequelae of SARS-CoV-2, sometimes called long COVID, are defined as signs and symptoms consistent with COVID-19 that extend beyond 4 weeks from onset of infection and constitute an emerging health issue.1 Common symptoms of post–COVID-19 conditions include fatigue, brain fog, dyspnea, digestive issues, loss of taste and smell, and depression,2,3 which may persist for months after init...

Myocarditis After BNT162b2 COVID-19 Third Booster Vaccine in Israel
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.060961
Circulation Mevorach D, .

Sep 7th, 2022

Another Approval Bites the Dust; Booze-Cancer Link Off Radar; Lung Ca Surveillance
https://www.medpagetoday.com/hematologyoncology/othercancers/102029

Dec 2nd, 2022 - Roche/Genentech will voluntarily withdraw accelerated approval of atezolizumab (Tecentriq) for advanced bladder cancer. The move follows the failure of a phase III trial to show a benefit in overall survival. Cryotherapy proved more effective than thermal ablation of small renal tumors, according to a retrospective comparison of the two strategies. (Journal of Urology) A survey of 3,865 U.S. ad...

New IDH1 Inhibitor Wins FDA Approval for Acute Myeloid Leukemia
https://www.medpagetoday.com/hematologyoncology/leukemia/102019

Dec 2nd, 2022 - The FDA approved the IDH1 inhibitor olutasidenib (Rezlidhia) for relapsed or refractory acute myeloid leukemia (AML). The approved indication stipulates use of olutasidenib in relapsed/refractory AML associated with an IDH1 mutation. The FDA also approved the Abbott RealTime IDH1 Assay as a companion diagnostic to select patients for olutasidenib. "Rezlidhia is a novel, non-intensive monotherap...

High-Contact Object and Surface Contamination in a Household of Persons with Monkeypox Virus Infection — Utah, June 2022
https://www.cdc.gov/mmwr/volumes/71/wr/mm7134e1.htm?s_cid=mm7134e1.htm_x
MMWR and Morbidity and Mortality Weekly Report; Pfeiffer JA, Collingwood A et. al.

Aug 19th, 2022 - In May 2022, the Salt Lake County Health Department reported two real-time polymerase chain reaction (PCR)–confirmed travel-associated cases of monkeypox to the Utah Department of Health and Human Services (UDHHS). The two persons with monkeypox (patients A and B) lived together without other housemates. Both persons experienced prodromal symptoms (e.g., fatigue and body aches).

Modulation of human endogenous retroviruses and cytokines expression in peripheral bloo...
https://doi.org/10.1186/s12977-022-00603-6
Retrovirology Cipriani C, Giudice M et. al.

Dec 2nd, 2022 - Putative pathogenic effects mediated by human endogenous retroviruses (HERVs) in neurological and psychiatric disorders in humans have been extensively described. HERVs may alter the development of the brain by means of several mechanisms, including modulation of gene expression, alteration of DNA stability, and activation of immune system. We recently demonstrated that autistic children and th...

Comparison of the clinical outcomes between vascularized bone graft and the Masquelet t...
https://doi.org/10.1186/s12891-022-06010-4
BMC Musculoskeletal Disorders; Lan CY, Lien PH et. al.

Dec 2nd, 2022 - Gustilo type III tibial fractures commonly involve extensive soft tissue and bony defects, requiring complex reconstructive operations. Although several methods have been proposed, no research has elucidated the efficacies and differences between vascular bone graft (VBG) and the Masquelet technique (MT) to date. We aimed to evaluate and compare the clinical effectiveness of VBG and the MT for ...

Predictors of weight loss during the intensive phase of tuberculosis treatment in patie...
https://doi.org/10.1093/pubmed/fdac141
Journal of Public Health (Oxford, England); Kalva J, Babu SP et. al.

Dec 2nd, 2022 - Tuberculosis (TB) is well-known for causing wasting. Patients on treatment gain weight and weight loss is associated with unfavorable treatment outcomes. There is limited description of weight loss and its predictors during intensive treatment phase. The objective of this study was to assess the predictors of weight loss during intensive phase and to see if there is any association exists with ...

Extracellular vesicle long RNA markers of early-stage lung adenocarcinoma.
https://doi.org/10.1002/ijc.34386
International Journal of Cancer; Zhang Y, Liu W et. al.

Dec 2nd, 2022 - Lung cancer screening by low-dose computed tomography (LDCT) can improve mortality rates among high-risk individuals, especially adenocarcinoma cases with characteristically poor prognosis, although high false-positive rates have limited its clinical application. The objective of this study was to identify biomarkers for early-stage lung adenocarcinoma (i.e., tumor diameter <2 cm) through extra...

A disease-targeted picture book for children with Henoch-Schonlein purpura nephritis: A...
https://doi.org/10.1111/jorc.12451
Journal of Renal Care; Tang Y, Chen W et. al.

Dec 2nd, 2022 - Children with Henoch-Schonlein purpura nephritis are frequently burdened with psychological problems besides disease treatment and adherence. Currently, there is a shortage of appropriate and effective educational materials to facilitate physical and psychological recovery. To examine a picture book for the effectiveness of disease-related knowledge, coping strategies, resilience, quality of li...

T1w/FLAIR ratio standardization as a myelin marker in MS patients.
https://doi.org/10.1016/j.nicl.2022.103248
NeuroImage. Clinical; Cappelle S, Pareto D et. al.

Dec 2nd, 2022 - Calculation of a T1w/T2w ratio was introduced as a proxy for myelin integrity in the brain of multiple sclerosis (MS) patients. Since nowadays 3D FLAIR is commonly used for lesion detection instead of T2w images, we introduce a T1w/FLAIR ratio as an alternative for the T1w/T2w ratio. Bias and intensity variation are widely present between different scanners, between subjects and within subjects...