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About 1,059,878 results

Concomitant disease should be considered when treating progressive glaucoma
https://www.healio.com/news/ophthalmology/20220120/concomitant-disease-should-be-considered-when-treating-progressive-glaucoma

Jan 20th, 2022 - WAIKOLOA, Hawaii — Ophthalmologists should consider co-management of other diseases when treating progressive glaucoma, according to a speaker here. “I think that we need to remind ourselves, even as we rush through clinic, to think about the linkage to common disease that puts the optic nerve at risk,” Jeffrey L. Goldberg, MD, PhD, said at Hawaiian Eye 2022. To aid with co-management, he said,...

Chang highlights new trends in antibiotic prophylaxis for endophthalmitis
https://www.healio.com/news/ophthalmology/20220118/chang-highlights-new-trends-in-antibiotic-prophylaxis-for-endophthalmitis

Jan 18th, 2022 - WAIKOLOA, Hawaii — Just past the 15-year anniversary of the cefuroxime ESCRS trial, debate regarding antibiotic prophylaxis for endophthalmitis after cataract surgery continues. “When you have something controversial, it's nice to see what our colleagues are doing,” David F. Chang, MD, said at Hawaiian Eye 2022. To that end, surveys of ASCRS members conducted in 2007, 2014 and 2021 published in...

How to avoid the perils of uveitis diagnostic management
https://www.healio.com/news/ophthalmology/20220116/how-to-avoid-the-perils-of-uveitis-diagnostic-management

Jan 16th, 2022 - WAIKOLOA, Hawaii — It is important for physicians to consider “the perils that dwell” in the diagnostic management of patients with uveitis, Steven Yeh, MD, said during a presentation at Hawaiian Eye 2022. “With these patients being very complex oftentimes, we really just don’t want to miss something,” Yeh said. To better identify “the pearls amongst the perils” in uveitis diagnosis, it is impo...

Natural History and Development of Spondyloarthritis
https://clinicaltrials.gov/ct2/show/NCT01422694

Jul 1st, 2022 - The purpose of this protocol is to study the natural history of spondyloarthritis (SpA) in children and adults. Spondyloarthritis encompasses a spectrum of immune-mediated inflammatory diseases that exhibit overlapping features, but differ from other types of inflammatory arthritis in genetic predisposition, pathogenesis, and outcome. Ankylosing spondylitis (AS), the most common form of SpA, fr...

A Study to Evaluate Subcutaneous Daratumumab in Combination With Standard Multiple Myeloma Treatment Regimens
https://clinicaltrials.gov/ct2/show/NCT03412565

Jun 21st, 2022 - The hypothesis is that the addition of daratumumab administered SC to standard MM regimens will improve responses compared to response data observed in completed phase 3 studies without daratumumab. Disease evaluations will include measurements of myeloma proteins, bone marrow examinations, skeletal surveys, assessment of extramedullary plasmacytomas, and measurements of serum calcium corrected...

The impact of a structured weight-loss treatment on physical fitness in patients with p...
https://doi.org/10.1007/s10067-022-06164-5 10.1056/NEJMra1505557 10.1111/1756-185X.12283 10.1093/rheumatology/ker349 10.1080/03009742.2019.1672783 10.3899/jrheum.171034 10.2174/1574887113666180314105511 10.1136/annrheumdis-2014-206824 10.1161/CIRCRESAHA.115.306883 10.1016/j.mayocp.2018.01.016 10.1007/s11695-013-0924-0 10.1016/S0140-6736(16)00271-3 10.1046/j.1467-789x.2001.00026.x 10.1249/MSS.0000000000001074 10.1111/obr.12422 10.1016/j.archger.2016.02.004 10.1016/j.physio.2015.05.003 10.1136/ard.51.1.35 10.1186/s13075-019-1810-5 10.1186/s13075-020-02350-5 10.1002/art.21972 10.3109/03009749309095105 10.1016/0002-9343(85)90465-6 10.1152/jappl.1954.7.2.218 10.1186/1471-2474-15-305 10.1097/00005650-199206000-00002 10.1111/sms.12611 10.1002/art.23568 10.1136/ard.2009.122259 10.1146/annurev.nutr.21.1.323 10.1002/oby.22476 10.1016/j.bone.2009.10.013 10.1002/art.33394 10.1001/jama.2009.681 10.1080/00913847.2019.1623995 10.1016/j.semarthrit.2004.07.010 10.3945/an.116.014506 10.1007/s11926-012-0263-5 10.1002/acr.24126 10.7762/cnr.2019.8.2.148 10.1186/s12905-019-0864-5
Clinical Rheumatology; Bilberg A, Larsson I et. al.

Jun 2nd, 2022 - To evaluate the effects of weight loss treatment on physical fitness in patients with psoriatic arthritis (PsA) and obesity compared to matched controls. In total, 46 patients with PsA (CASPAR) and BMI ≥ 33 kg/m2 and 52 obese persons were included in this 12-month prospective open intervention study with a very low energy diet (640 kcal/day), followed by structured reintroduction of an energy-r...

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
https://doi.org/10.1002/art.41752
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

Fluconazole - fluconazole tablet-REMEDYREPACK INC.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d11e0926-cd15-49ba-b0ee-2b6d4e009dd8

Dec 30th, 2022 - Fluconazole tablets are indicated for the treatment of: Vaginal candidiasis (vaginal yeast infections due to Candida). Oropharyngeal and esophageal candidiasis. In open noncomparative studies of relatively small numbers of patients, fluconazole tablets were also effective for the treatment of Candida urinary tract infections, peritonitis, and systemic Candida infections including candidemia, di...

Clues to Long COVID
https://www.science.org/content/article/what-causes-long-covid-three-leading-theories
Science Couzin-Frankel J.

Jun 16th, 2022 - They span three continents, but a trio of researchers who’ve never met share a singular focus made vital by the still-raging pandemic: deciphering the causes of Long Covid and figuring out how to treat it. Almost 2 years ago in Italy, pediatric infectious disease doctor Danilo Buonsenso, who works at Gemelli University Hospital, started to see children who, months after mild infections with ...

Risk factors for SARS-CoV-2 infection and transmission in households with asthmatic and allergic children. A prospective surveillance study
https://www.jacionline.org/article/S0091-6749(22)00752-7/fulltext
The Journal of Allergy and Clinical Immunology; Seibold MA, .

May 31st, 2022 - Whether children and people with asthma and allergic diseases are at increased risk for SARS-CoV-2 infection is unknown.

TG Therapeutics Announces Voluntary Withdrawal of the BLA/sNDA for U2 to Treat Patients with CLL and SLL
https://ir.tgtherapeutics.com/news-releases/news-release-details/tg-therapeutics-announces-voluntary-withdrawal-blasnda-u2-treat
TG Therapeutics

Apr 15th, 2022 - NEW YORK, April 15, 2022 (GLOBE NEWSWIRE) -- TG Therapeutics, Inc. (NASDAQ: TGTX), today announced that the Company has voluntarily withdrawn the pending Biologics License Application (BLA)/supplemental New Drug Application (sNDA) for the combination of ublituximab and UKONIQ® (umbralisib) (combination referred to as U2) for the treatment of adult patients with chronic lymphocytic leukemia (CLL...

Ambient air pollution and COVID-19 risk: Evidence from 35 observational studies
https://www.sciencedirect.com/science/article/pii/S0013935121013608?via=ihub
Environmental Research; Zang ST, .

Mar 30th, 2022 - Coronavirus disease 2019 (COVID-19) is induced by a previously undiscovered coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Lu et al., 2020). Since SARS-CoV-2 was first discovered in December 2019, as of April 25, 2021, more than four million fatalities have been attributed to COVID-19, accounting for approximately 2% of the infected cases (>214 million)...

WHO consolidated guidelines on tuberculosis Module 5: Management of tuberculosis in children and adolescents
https://www.who.int/publications/i/item/9789240046764
World Health Organization (WHO)

Mar 21st, 2022 - The Updated guidelines on Management of tuberculosis in children and adolescents include new recommendations that cover diagnostic approaches for TB, shorter treatment for children with non-severe drug-susceptible TB, a new option for the treatment of TB meningitis, the use of bedaquiline and delamanid in young children with multidrug- and rifampicin-resistant TB and decentralized and family-ce...

Perinatal risk factors for SUDEP: A population-based case-control study.
https://doi.org/10.1111/epi.17354
Epilepsia Sveinsson O, Andersson T et. al.

Jul 3rd, 2022 - Sudden unexpected death in epilepsy (SUDEP) is a leading epilepsy related cause of death. Researchers have highlighted the similarities between SUDEP and Sudden infant death syndrome (SIDS) but perinatal risk factors such as those identified for SIDS, have not been assessed previously for SUDEP. We carried out a population-based case-control of 58 SUDEP individuals and 384 living epilepsy contr...

Immunopathology of the Optic Nerve in Multiple Sclerosis.
https://doi.org/10.1093/cei/uxac063
Clinical and Experimental Immunology; Fernández Blanco L, Marzin M et. al.

Jul 3rd, 2022 - Optic neuritis, a primary clinical manifestation commonly observed in multiple sclerosis (MS) is a major factor leading to permanent loss of vision. Despite decreased vision (optic neuritis), diplopia, and nystagmus, the immunopathology of the optic nerve in MS is unclear. Here, we have characterised the optic nerve pathology in a large cohort of MS cases (n=154), focusing on the immune respons...

Eosinophilic Esophagitis: Immune Mechanisms and Therapeutic Targets.
https://doi.org/10.1111/cea.14196
Clinical and Experimental Allergy : Journal of the Britis... Khokhar D, Marella S et. al.

Jul 3rd, 2022 - Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease of the esophagus and is clinically characterized by upper gastrointestinal (GI) symptoms including dysphagia and esophageal food impaction. Histopathologic manifestations, which include intraepithelial eosinophilic inflammation and alterations of the esophageal squamous epithelium, such as basal zone hyperplasia (BZH) an...

Adjunctive treatment with infliximab in pediatric immunoglobulin A (IgA) vasculitis: A ...
https://doi.org/10.1111/pde.15077
Pediatric Dermatology; Castelli B, Marrani E et. al.

Jul 3rd, 2022 - Immunoglobulin A vasculitis (IgAV) is the most common childhood vasculitis affecting small vessels. No clear recommendations are available for severe pediatric cases, and until now, anti-TNF agents have had a limited role in IgAV management. In this report, we describe a pediatric case of severe IgAV, successfully treated with combined therapy including the anti-TNF, infliximab.

Multiomics to investigate the mechanisms contributing to repression of PTPRC and SOCS2 ...
https://doi.org/10.1002/gcc.23085
Genes, Chromosomes & Cancer; Drobna-Śledzińska M, Maćkowska-Maślak N et. al.

Jul 3rd, 2022 - T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous and aggressive malignancy arising from T cell precursors. MiRNAs are implicated in negative regulation of gene expression and when aberrantly expressed contribute to various cancer types, including T-ALL. Previously we demonstrated the oncogenic potential of miR-363-3p overexpression in a subgroup of T-ALL patients. Here, using comb...

Conditional knockout of ERα in CD11c+ cells impacts female survival and inflammatory cy...
https://doi.org/10.1111/imm.13541
Immunology Lennard Richard ML, Wirth JR et. al.

Jul 3rd, 2022 - Estrogen and estrogen receptor alpha (ERα) have been implicated in systemic lupus erythematosus (SLE) pathogenesis. ERα signaling influences dendritic cell (DC) development and function, as well as inflammation and downstream immune responses. We previously reported that ERα modulates multiple TLR-stimulated pathways in both conventional and plasmacytoid DCs in lupus-prone mice. For example, CD...

Plasma carnitine concentrations in Medium-Chain Acyl-CoA Dehydrogenase Deficiency : les...
https://doi.org/10.1002/jimd.12537
Journal of Inherited Metabolic Disease; Jager EA, Schaafsma M et. al.

Jul 3rd, 2022 - Our aim was to study the effect of secondary carnitine deficiency (SCD) and carnitine supplementation on important outcome measures for persons with Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCADD). We performed a large retrospective observational study using all recorded visits of persons with MCADD in the University Medical Center Groningen, the Netherlands, between October 1994 and Oct...