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About 874,323 results

SARS-CoV-2 vaccine protection and deaths among US veterans during 2021
https://www.science.org/doi/10.1126/science.abm0620
Science Cohn BA, .

Nov 4th, 2021 - The messenger RNA vaccines BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna) and the viral vector vaccine JNJ-78436735 (Janssen) have effectively prevented clinically significant disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since their rollout in the U.S. in late 2020 (1, 2).

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Clinical Edge Journal Scan Commentary: PsA December 2021
https://www.mdedge.com/rheumatology/article/249458/psoriatic-arthritis/clinical-edge-journal-scan-commentary-psa-december
Vinod Chandran, MBBS, MD, DM, PhD

Dec 4th, 2021 - Vinod Chandran, MBBS, MD, DM, PhD Research published in November has provided us with insights on the impact of psoriatic arthritis (PsA) as well as treatment outcomes. Although PsA often affects women of child-bearing age, data on pregnancy outcomes in PsA is scarce.

Intra abdominal hypertension in neonates following congenital diaphragmatic hernia repa...
https://doi.org/10.1016/j.jpedsurg.2021.10.029
Journal of Pediatric Surgery; Thambusamy E, Thambidorai CR et. al.

Dec 4th, 2021 - Increased intra abdominal pressure (IAP) is seen in patients after congenital diaphragmatic hernia (CDH) repair owing to reduction of thoracic contents into the relatively smaller abdominal cavity. In infants, IAP ≥11 mmHg is considered intra abdominal hypertension (IAH). We aim to determine the incidence of IAH and its relationship with duration of ventilatory support, and gastrointestinal fun...

Clinical trajectory of a patient with filaminopathy who developed arrhythmogenic cardio...
https://doi.org/10.1016/j.nmd.2021.10.002
Neuromuscular Disorders : NMD; Matsumura T, Inoue K et. al.

Dec 4th, 2021 - We report a case of a patient presenting with arrhythmogenic cardiomyopathy, myofibrillar myopathy, and multiorgan tumors. A 41-year-old woman with a history of hypertrophic cardiomyopathy, diagnosed at 6 years of age, developed scoliosis after puberty. Following spinal surgery to address the scoliosis, she developed recurrent severe arrhythmia and heart failure. She developed hypoventilation a...

Diagnostic delay in patients with FKRP-related muscular dystrophy.
https://doi.org/10.1016/j.nmd.2021.08.013
Neuromuscular Disorders : NMD; Coffey LN, Stephan CM et. al.

Dec 4th, 2021 - Diagnostic journey for people with FKRP mutations participating in a dystroglycanopathy natural history study (n = 68; NCT00313677) was analyzed. Earliest symptoms and age at muscular dystrophy diagnosis were abstracted from subject-reported medical history and record review. Initial signs/symptoms were classified as chronic motor dysfunction (e.g., delayed motor milestones, weakness, falling; ...

Risk assessment in pulmonary hypertension based on routinely measured laboratory parame...
https://doi.org/10.1016/j.healun.2021.10.018
The Journal of Heart and Lung Transplantation : the Offic... Yogeswaran A, Tello K et. al.

Dec 4th, 2021 - γ-glutamyl transferase (GGT), the aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio, and the neutrophil-to-lymphocyte ratio (NLR) are prognostic biomarkers in several cardiovascular diseases, but their relevance in pulmonary hypertension (PH) is not fully understood. We aimed to assess their prognostic value in patients with pulmonary arterial hypertension (PAH) and chronic th...

Elevated CD19+Siglec-10+ B cell levels are correlated with systemic lupus erythematosus...
https://doi.org/10.1016/j.intimp.2021.108403
International Immunopharmacology; Ju B, Wang J et. al.

Dec 4th, 2021 - Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by B cell dysregulation and the breakdown of self-tolerance, leading to pathogenic autoantibody production. Human Siglec-10 is a member of the sialic acid-binding immunoglobulin-type lectin (Siglec) family and a B cell surface coreceptor that inhibits B cell receptor-induced signalling. However, to date, no report ...

Rabies mortality and morbidity associated with animal bites in Africa: a case for integ...
https://doi.org/10.1136/bmjopen-2020-048551
BMJ Open; Nyasulu PS, Weyer J et. al.

Dec 4th, 2021 - The objective of this scoping review was to map the current situation and available evidence and gaps on rabies morbidity, mortality, integrated rabies surveillance programmes, and existing prevention and control strategies in Africa. We conducted a systematic scoping review following the Joanna Briggs methodology and Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension ...

Technical validation of real-world monitoring of gait: a multicentric observational study.
https://doi.org/10.1136/bmjopen-2021-050785
BMJ Open; Mazzà C, Alcock L et. al.

Dec 4th, 2021 - Existing mobility endpoints based on functional performance, physical assessments and patient self-reporting are often affected by lack of sensitivity, limiting their utility in clinical practice. Wearable devices including inertial measurement units (IMUs) can overcome these limitations by quantifying digital mobility outcomes (DMOs) both during supervised structured assessments and in real-wo...

Peyronie disease and erectile dysfunction: A potential new paradigm.
https://doi.org/10.3949/ccjm.88a.21027
Cleveland Clinic Journal of Medicine; Montague DK

Dec 4th, 2021 - Peyronie disease and erectile dysfunction: A potential new paradigm.|2021|Montague DK,|

An upper bound on one-to-one exposure to infectious human respiratory particles.
https://doi.org/10.1073/pnas.2110117118
Proceedings of the National Academy of Sciences of the Un... Bagheri G, Thiede B et. al.

Dec 4th, 2021 - There is ample evidence that masking and social distancing are effective in reducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. However, due to the complexity of airborne disease transmission, it is difficult to quantify their effectiveness, especially in the case of one-to-one exposure. Here, we introduce the concept of an upper bound for one-to-one exposure to ...

Follicular lymphoma treated with first-line immunochemotherapy: a review of PET-CT in p...
https://doi.org/10.2967/jnumed.121.262869
Journal of Nuclear Medicine : Official Publication, Socie... Barrington SF, Mir F et. al.

Dec 4th, 2021 - Complete metabolic response (CMR) on positron emission tomography-computed tomography (PET-CT) was the sole independent predictor of overall survival in the PET sub-study of the phase III GALLIUM trial (NCT01332968) in first-line treatment of high tumour burden follicular lymphoma (FL). The aim of this analysis was to investigate further the outcome of patients not achieving CMR. Methods: Two i...

Imaging the inflammatory response in checkpoint inhibition myocarditis.
https://doi.org/10.2967/jnumed.121.262301
Journal of Nuclear Medicine : Official Publication, Socie... Rischpler C, Rassaf T et. al.

Dec 4th, 2021 - Imaging the inflammatory response in checkpoint inhibition myocarditis.|2021|Rischpler C,Rassaf T,Umutlu L,Herrmann K,Schlosser TW,|

Diagnostic performances of cervical ultrasound, sestamibi scintigraphy and contrast-enh...
https://doi.org/10.2967/jnumed.121.261900
Journal of Nuclear Medicine : Official Publication, Socie... Boudousq V, Guignard N et. al.

Dec 4th, 2021 - Purpose: Preoperative localization of pathological parathyroids is crucial for a minimally invasive treatment of primary hyperparathyroidism (PHPT). This study compares contrast-enhanced 18F-fluorocholine positron emission tomography (FCH-PET/CT), cervical ultrasound (CU) and conventional scintigraphic imaging modalities (MIBI scintigraphy), combined and individually for preoperative localizati...

Has the Time Come for Systematic Therapeutic Drug Monitoring of First-line and WHO Grou...
https://doi.org/10.1097/FTD.0000000000000948
Therapeutic Drug Monitoring; Lemaitre F

Dec 4th, 2021 - Tuberculosis (TB) is a major global health issue, with approximately 10 million people being infected each year, and is the leading cause of mortality from infectious disease, with 1.5 million deaths a year. Optimal TB treatment requires a combination of drugs for an adequate treatment duration owing to persistent organisms, hardly accessible infection sites, and a high risk of resistance selec...

Primary plasma cell leukemia: consensus definition by the International Myeloma Working...
https://doi.org/10.1038/s41408-021-00587-0 10.1016/0002-9343(87)90942-9 10.1001/archinte.133.5.813 10.1111/bjh.15092 10.1182/blood-2014-03-565051 10.1182/blood.V93.3.1032 10.1111/j.1365-2141.1994.tb05114.x 10.1016/S0889-8588(05)70125-8 10.1038/leu.2012.336 10.1002/cncr.31718 10.1038/leu.2008.4 10.1038/s41408-018-0153-9 10.1182/blood.V88.1.289.289 10.1038/leu.2016.205 10.1007/s00277-014-2211-0 10.3324/haematol.2016.158303 10.1038/s41408-018-0140-1 10.1182/blood-2020-141525 10.1038/leu.2012.107 10.1158/1078-0432.CCR-12-2043 10.1016/j.leukres.2018.09.007 10.1182/blood-2012-05-408682 10.1038/leu.2011.312 10.1002/ajh.23600 10.1093/annonc/mdr480 10.1038/leu.2013.241 10.1200/JCO.2015.63.1929 10.3324/haematol.2009.013334 10.1038/leu.2014.98 10.1182/blood-2005-05-1858 10.1111/bjh.13484 10.1038/s41408-018-0153-9 10.1080/10428190601016159 10.1080/1042819021000029713
Blood Cancer Journal; Fernández de Larrea C, Kyle R et. al.

Dec 4th, 2021 - Primary plasma cell leukemia (PCL) has a consistently ominous prognosis, even after progress in the last decades. PCL deserves a prompt identification to start the most effective treatment for this ultra-high-risk disease. The aim of this position paper is to revisit the diagnosis of PCL according to the presence of circulating plasma cells in patients otherwise meeting diagnostic criteria of m...

HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a po...
https://doi.org/10.1038/s41388-021-02126-4
Oncogene Page EC, Heatley SL et. al.

Dec 4th, 2021 - The genetic basis of the predisposition for Down Syndrome (DS) patients to develop cytokine receptor-like factor 2 rearranged (CRLF2r) acute lymphoblastic leukemia (ALL) is currently unknown. Genes located on chromosome 21 and expressed in hematopoietic cells are likely candidates for investigation of CRLF2r DS-ALL pathogenesis. We explored the high-mobility group nucleosome-binding protein 1 (...

Isocitrate dehydrogenase mutations are associated with altered IL-1β responses in acute...
https://doi.org/10.1038/s41375-021-01487-9
Leukemia Sunthankar KI, Jenkins MT et. al.

Dec 4th, 2021 - Mutations in isocitrate dehydrogenase 2 (IDH2) have been noted to impact cellular differentiation in addition to DNA and histone methylation. However, little is known about the impact of IDH2 mutations on intracellular signaling. Using an isogenic cell line model, we investigated both differentiation and signaling responses in IDH2 mutant cells and show augmented responses to inflammatory immun...

Immunogenicity and safety of mRNA COVID-19 vaccines in people with multiple sclerosis t...
https://doi.org/10.1007/s13311-021-01165-9 10.1016/j.ijbiomac.2020.06.213 10.1016/j.msard.2021.102788 10.1016/j.msard.2021.102880 10.1016/j.msard.2020.102439 10.1016/j.jneuroim.2021.577599 10.1177/13524585211003476 10.1038/s41586-020-2852-1 10.1038/s41591-021-01377-8 10.1177/17562864211012835 10.1016/j.neurol.2021.05.001 10.1016/j.msard.2021.102983 10.1016/s1474-4422(17)30470-2 10.15585/mmwr.mm6950e2 10.1111/ene.15028 10.1177/17562864211038111 10.1016/j.msard.2021.103150 10.1212/wnl.0000000000010380 10.1016/j.ijid.2021.06.054 10.1056/NEJMc2108861 10.1002/jcla.23921
Neurotherapeutics : the Journal of the American Society F... Capone F, Lucchini M et. al.

Dec 4th, 2021 - The potential impact of disease-modifying therapies (DMTs) for multiple sclerosis (MS) on COVID-19 vaccination is poorly understood. According to recent observations, the humoral immune response could be impaired in patients treated with ocrelizumab or fingolimod. Our study evaluated the immunogenicity and safety of mRNA COVID-19 vaccines in a convenience sample of 140 MS patients treated with ...