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About 208,510 results

Gene Therapy Shows Clinical Benefit in Metachromatic Leukodystrophy
https://www.medpagetoday.com/neurology/generalneurology/96836

Jan 24th, 2022 - An investigational gene therapy showed benefit in pediatric patients with early-onset metachromatic leukodystrophy (MLD), a small study showed. Treatment with atidarsagene autotemcel (arsa-cel) preserved motor development and cognitive function in MLD patients enrolled in a prospective phase I/II trial or treated through expanded access programs, reported Alessandro Aiuti, MD, of the San Raffae...

Abraxane still in short supply for cancer patients
https://www.mdedge.com/hematology-oncology/article/251049/lung-cancer/abraxane-still-short-supply-cancer-patients
Jim Kling

Jan 24th, 2022 - Abraxane, a chemotherapy treatment for advanced pancreatic cancer, advanced non–small cell lung cancer and metastatic breast cancer, is on allocation through early March because of manufacturing delays, forcing physicians to find alternatives for a drug once lauded for being easier to tolerate. Abraxane (Bristol-Myers Squibb) is a paclitaxel albumin-bound injectable.

Dirofilaria immitis Pulmonary Dirofilariasis, Slovakia
https://wwwnc.cdc.gov/eid/article/28/2/21-1963_article

Jan 23rd, 2022 - Dirofilaria immitis is a filarioid nematode that infects numerous mammalian species. Dogs are the main reservoir and various mosquito species (e.g., genera Culex, Anopheles, Aedes, and Ochlerotatus) the infection vectors. The parasite is related to the pulmonary form of dirofilariasis, manifested by the formation of coin lesions or nodules in lung parenchyma in humans, an accidental parasite ho...

Quality of life and mortality among survivors of acute respiratory distress syndrome in...
https://doi.org/10.1007/s00540-022-03036-9 10.3390/ijms18010064 10.1001/jama.2016.0291 10.4187/respcare.04716 10.1007/s00134-006-0217-3 10.1001/jama.281.4.354 10.1007/s00134-003-1808-x 10.1164/rccm.200406-763OC 10.1378/chest.10-2438 10.1186/s12889-020-08943-8 10.1007/s00134-016-4321-8 10.1056/NEJMoa1011802 10.1164/rccm.201611-2327OC 10.1136/thoraxjnl-2017-210217 10.1136/thoraxjnl-2016-208560 10.1016/j.ijsu.2014.07.013 10.1001/jama.2012.5669 10.4046/trd.2017.80.2.105 10.1097/CCM.0000000000003015 10.1016/j.jcrc.2021.04.018 10.1186/s12889-020-10042-7 10.1186/s12931-021-01796-8 10.1186/s12913-020-05778-2 10.1007/s11136-021-02865-7 10.1016/j.chest.2016.06.032
Journal of Anesthesia; Choi HR, Song IA et. al.

Jan 22nd, 2022 - Worsening quality of life (QOL) is an important health issue in acute respiratory distress syndrome (ARDS) survivors. We aimed to investigate the prevalence of worsening QOL among ARDS survivors and their association with mortality. South Korean National Health Insurance database information for all adults admitted to intensive care units for ARDS from January 1, 2010 to December 31, 2018 who s...

Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year...
https://doi.org/10.1007/s00431-021-04358-8 10.1007/s00431-020-03783-5 10.1001/jamanetworkopen.2021.7523 10.1038/s41467-020-17436-6 10.1016/j.jmii.2020.02.011 10.1097/INF.0000000000002862 10.1542/neo.22-5-e1001 10.1542/peds.2020-0702 10.3389/fped.2020.00431 10.1016/j.eclinm.2020.100433 10.3389/fped.2021.631547 10.1080/14767058.2020.1849124 10.1055/s-0040-1712457 10.1542/peds.2020-0961 10.1016/S2352-4642(20)30140-1 10.1542/peds.2020-023432 10.1038/s41467-020-18982-9 10.1093/infdis/jiaa113 10.1007/s00431-020-03699-0 10.1136/archdischild-2020-319837 10.1016/S2352-4642(20)30235-2 10.1016/S2352-4642(20)30177-2 10.1016/j.peds.2020.11.016
European Journal of Pediatrics; Akin IM, Kanburoglu MK et. al.

Jan 22nd, 2022 - The literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care un...

Shifting Epidemiology of Hepatocellular Carcinoma in Far Eastern and Southeast Asian Pa...
https://doi.org/10.1007/s11912-021-01160-5
Current Oncology Reports; Tran NH

Jan 22nd, 2022 - Liver cancer is a major health burden globally with high rates in the Far East and Southeast Asia. Hepatitis B virus and hepatitis C virus remain the major causes of hepatocellular carcinoma (HCC) worldwide; however, the epidemiology is changing. Here, we review the changing epidemiological changes among Far East and Southeast Asians and among Asian Americans in the USA. HBV- and HCV-induced HC...

Clinical Disease Measures in Generalized Pustular Psoriasis.
https://doi.org/10.1007/s40257-021-00653-0 10.1038/jid.2009.391 10.1111/jdv.14386 10.1007/s00403-002-0371-6 10.1080/1744666X.2019.1708193 10.1016/j.jaad.2009.11.022 10.1111/j.1365-2133.2004.05777.x 10.3109/09546634.2013.865009 10.1016/j.jaad.2004.04.012 10.1001/jamadermatol.2014.3513 10.1111/1346-8138.13622 10.1111/1523-1747.ep12384205 10.1056/NEJMc1811317 10.1136/bmjopen-2020-043666 10.1111/1346-8138.13306 10.1111/1346-8138.14294 10.1111/bjd.14702 10.1016/j.comppsych.2008.08.005 10.1111/1346-8138.13927 10.1111/1346-8138.14664 10.1080/00325481.2020.1831315 10.1111/pde.14155 10.1155/2013/702763 10.1111/ijd.12070 10.1111/1346-8138.15657 10.1111/j.1365-2230.1994.tb01167.x 10.1684/ejd.2020.3878 10.1111/bjd.14788
American Journal of Clinical Dermatology; Burden AD, Choon SE et. al.

Jan 22nd, 2022 - Generalized pustular psoriasis (GPP) is a rare neutrophilic skin condition characterized by episodes of widespread eruption of sterile macroscopic pustules that can be associated with systemic inflammation. The rarity of GPP and its heterogeneous cutaneous and extracutaneous symptoms pose considerable challenges to the development and adoption of comprehensive accurate disease measures for the ...

Sexual problems in patients with hematological diseases: a systematic literature review.
https://doi.org/10.1007/s00520-021-06731-7 10.1016/s1470-2045(14)70282-7 10.1016/j.hemonc.2017.05.009 10.1080/13697137.2018.1526893 10.1002/cncr.31333 10.1016/b978-0-444-63247-0.00002-x 10.1111/j.1743-6109.2009.01620.x 10.1080/13697137.2019.1575356 10.1200/jco.2017.76.3839 10.1016/j.jpainsymman.2010.12.008 10.1182/asheducation-2005.1.523 10.1080/00224499.2017.1332153 10.1007/s13187-019-01559-6.41 10.1038/s41409-017-0027-y 10.1111/ecc.12216 10.1002/pon.1947 10.1200/JCO.2009.22.5474 10.1038/sj.bmt.1705613 10.1016/j.pec.2020.03.007 10.7326/m14-2385 10.1111/bjh.12651 10.1002/(SICI)1097-0142(19991001)86:7<1231::AID-CNCR18>3.0.CO;2-Y 10.1038/sj.thj.6200251 10.1001/jama.1979.03300170028021 10.3324/haematol.11987 10.1038/bjc.2012.550 10.1007/BF00396383 10.1111/jocn.12354 10.1093/oxfordjournals.annonc.a058768 10.1016/j.esxm.2020.04.005 10.1111/j.1600-0609.1984.tb00707.x 10.1016/S0959-8049(98)00269-X 10.1023/A:1008297130258 10.1016/j.psym.2018.01.006 10.1002/pon.1679 10.1200/jco.1993.11.5.979 10.1002/pon.2960010206 10.1200/jco.1986.4.5.805 10.1188/11.onf.e351-e359 10.1200/jco.2009.27.15_suppl.9510 10.1002/cncr.30013 10.1007/s00277-017-2940-y 10.1007/s00520-007-0307-y 10.1038/bjc.1998.217 10.1192/bjp.147.3.295 10.1007/bf00435972 10.1111/j.1743-6109.2012.02995.x 10.1186/1477-7525-11-40 10.1111/jsm.12966 10.1002/cam4.1338 10.1111/j.1743-6109.2010.01778.x 10.1016/j.eururo.2004.08.017 10.1016/j.jsxm.2015.12.034 10.1016/S0140-6736(13)62366-1 10.1097/NCC.0b013e31819b5a93 10.1002/pon.1542 10.1182/blood-2011-01-328955.P 10.1007/s10508-019-1443-4 10.1002/pon.3736 10.1016/j.jsxm.2016.05.017
Supportive Care in Cancer : Official Journal of the Multi... Eeltink C, Embaby A et. al.

Jan 22nd, 2022 - Sexual problems are frequently reported by recipients of hematopoietic stem cell transplantation (HCT). However, little is known about the impact of hematological malignancies and their treatments, without HCT being a part of the treatment regimen. The goal of this systematic review was to examine the prevalence of various sexual problems among patients treated for hematological malignancies wi...

Telemedicine Lessons Learned During the COVID-19 Pandemic.
https://doi.org/10.1007/s11882-022-01026-1 10.15585/mmwr.mm6950a4 10.1177/1357633X16652288 10.1089/tmj.2013.0256 10.1089/tmj.2017.0265 10.1016/j.mayocpiqo.2021.06.006 10.1097/ACM.0000000000003711 10.1007/s11606-020-05878-z 10.1177/1357633X16644095 10.1016/j.jaad.2017.09.017 10.1001/jamainternmed.2020.5928 10.15585/mmwr.mm7007a3
Current Allergy and Asthma Reports; Greiwe J

Jan 22nd, 2022 - Prior to the SARS-CoV-2 novel coronavirus (COVID-19) pandemic, access and utilization of telemedicine in the USA was negligeable, with very little interest from both the public and healthcare sectors. Since that time, telemedicine technology and services have undergone explosive growth and investment and are poised to change the way healthcare is delivered now and in the future. But has telemed...

Improvements in Awareness and Testing Have Led to a Threefold Increase Over 10 Years in...
https://doi.org/10.2337/dc21-2056
Diabetes Care; Pang L, Colclough KC et. al.

Jan 22nd, 2022 - Maturity-onset diabetes of the young (MODY) is a rare monogenic form of diabetes. In 2009, >80% of U.K. cases were estimated to be misdiagnosed. Since then, there have been a number of initiatives to improve the awareness and detection of MODY, including education initiatives (Genetic Diabetes Nurse [GDN] project), the MODY probability calculator, and targeted next-generation sequencing (tNGS)....

Shapiro Syndrome: Recurrent Hyperhidrosis and Hypothermia With Corpus Callosum Agenesis.
https://doi.org/10.1212/WNL.0000000000200101
Neurology Jiang F, Tang Z et. al.

Jan 22nd, 2022 - Shapiro Syndrome: Recurrent Hyperhidrosis and Hypothermia With Corpus Callosum Agenesis.|2022|Jiang F,Tang Z,Zhong D,Li G,|

Critical pathways of oral squamous cell carcinoma: molecular biomarker and therapeutic ...
https://doi.org/10.1007/s12032-021-01633-4 10.3126/nje.v6i4.17255 10.1038/nrg1879 10.1186/s41241-017-0046-4 10.1158/1078-0432.CCR-03-0249 10.1016/j.oooo.2013.01.022 10.1126/science.1208130 10.1093/carcin/bgm008 10.1126/science.285.5429.895 10.1002/hed.21365 10.12659/msm.905035 10.4103/0377-4929.182037 10.21873/cgp.20121 10.1093/carcin/bgy107 10.1038/labinvest.2015.163 10.1158/2159-8290.CD-13-0103 10.1016/j.cca.2012.11.027 10.1016/j.celrep.2018.10.007 10.1128/MCB.23.17.6139-6149.2003 10.1016/j.tcb.2018.07.002 10.1200/JCO.2005.03.7689 10.1111/j.1600-0714.2010.00909.x 10.5037/jomr.2015.6204 10.4103/0973-029X.131896 10.1007/s12094-016-1565-2 10.1002/mc.22119 10.1371/journal.pone.0056020 10.1002/ijc.22262 10.1016/j.bbrc.2015.09.181 10.1016/j.taap.2012.04.023 10.1371/journal.pone.0205518 10.4236/jct.2013.44100 10.1016/s0925-4439(01)00080-1 10.1016/j.cdp.2004.10.003 10.1002/1097-0142(20011215)92:12 10.1016/j.bbadis.2018.03.004 10.1002/cam4.1453 10.1038/ncomms6835 10.1111/j.1365-2273.1991.tb00975.x 10.1159/000094761 10.1158/1078-0432 10.1038/onc.2012.47 10.1016/j.joms.2004.02.002 10.1186/s12929-014-0067-1 10.1038/bjc.2014.221 10.1186/s11658-018-0127-8 10.1007/s00726-015-2070-6 10.1007/s11010-017-3241-4 10.1038/srep45624 10.3892/mmr.2016.5769 10.1016/j.biocel.2006.11.011 10.1038/35077241 10.1073/pnas.1232344100 10.1038/nrc2148 10.1371/journal.pone.0050517 10.1002/cncr.25125 10.1007/s12551-018-0445-0 10.3390/ijms21072581 10.1158/0008-5472 10.1016/j.molonc.2013.10.003 10.1016/j.cca.2011.09.031 10.4143/crt.2018.105 10.1007/s12094-013-1031-3 10.1186/s13046-019-1167-2 10.1007/s12094-016-1565-2 10.1016/s0248-4900(01)01125-x 10.1158/0008-5472 10.3390/ijms18010010 10.1074/jbc.M306968200 10.1007/s00280-018-3746-x 10.18632/oncotarget.19817 10.1038/s41598-020-73249-z 10.1038/sj.onc.1206701 10.1172/JCI124049 10.1038/nm0202-128 10.3892/or.2011.1146 10.1093/carcin/bgl039 10.1016/j.prostaglandins.2010.07.002 10.1016/j.intimp.2009.02.003 10.1111/j.1349-7006.2011.02174.x 10.3892/ijo.2013.1786 10.1158/1078-0432.CCR-05-0301 10.1517/13543784.2011.559162 10.1002/tox.22769 10.1016/j.archoralbio 10.1007/s13277-015-4583-8 10.1016/j.biopha.2017.12.009 10.1002/ptr.5561 10.3390/ijms19030729 10.3390/ijms20061306 10.37290/ctnr2641-452X.18:273-276 10.1073/pnas.2017152117 10.20892/j.issn.2095-3941.2018.0257 10.1142/S0192415X1850060X 10.1177/1078155217722406 10.1016/j.oraloncology.2017.03.009 10.18632/oncotarget.19817 10.1038/nrclinonc.2016.196 10.1371/journal.pone.0101525 10.1016/j.canlet.2015.02.034 10.1016/j.bbrc.2011.05.027 10.1074/jbc.M414589200 10.1016/j.jnutbio.2008.09.007 10.1016/j.oraloncology.2015.03.007
Medical Oncology (Northwood, London, England); Dey S, Singh AK et. al.

Jan 22nd, 2022 - The rapid growth of oral cancer is a significant concern, especially in developing countries due to the advanced lifestyle and 5-year survival despite advanced multimodality of cancer care. The poor modality might be due to the detection of disease in the advanced stage. Early detection and development of novel therapies can improve oral cancer patient survival. The PI3K/AKT/mTOR and RAS-RAF-ME...

Characteristics of the first 1,119 SARS-CoV-2 Omicron variant cases, in Marseille, Fran...
https://doi.org/10.1002/jmv.27613
Journal of Medical Virology; Houhamdi L, Gautret P et. al.

Jan 22nd, 2022 - 1,119 cases of SARS-CoV-2 Omicron variant cases have been diagnosed at IHU Méditerranée Infection, Marseille, France, between November 28, 2021 and December 31, 2021. Among the 825 patients with a known vaccination status, 383 (46.4%) were vaccinated of whom 91.9% had received at least two doses of the vaccine. Interestingly, 26.3% of cases developed SARS-CoV-2 infection within 21 days followin...

Unmet Needs of Women Living with Parkinson's Disease: Gaps and Controversies.
https://doi.org/10.1002/mds.28921
Movement Disorders : Official Journal of the Movement Dis... Subramanian I, Mathur S et. al.

Jan 22nd, 2022 - Personalized medicine considering sex, gender, and cultural context has become the vanguard of delivery of care. However, women's issues in Parkinson disease (PD), especially from a psychosocial standpoint, have been an overlooked field. The key research areas include women-inclusive drug and device studies and genetic and hormonal considerations. Moreover, women with PD need to be educated and...

Low fetal age is not a contraindication for extracorporeal membranous oxygenation in CO...
https://doi.org/10.1111/jocs.16251
Journal of Cardiac Surgery; Zalle I, Barthelemy Y et. al.

Jan 22nd, 2022 - The coronavirus disease 2019 (COVID-19) causes a small proportion of patients to be admitted to intensive care units, where they sometimes require extracorporeal membrane oxygenation (ECMO). The literature on pregnant women with COVID-19 who require ECMO is sparse. We describe here the earliest-fetal-age pregnant patient with COVID-19 who underwent ECMO yet reported, who kept her child while un...

Thrombotic and Clinical Outcomes in Patients with Hematologic Malignancy and COVID-19.
https://doi.org/10.1016/j.clml.2021.12.011
Clinical Lymphoma, Myeloma & Leukemia; Cook MR, Dykes K et. al.

Jan 22nd, 2022 - Venous thromboembolism (VTE) is a common complication in acute COVID-19 and those with hematologic malignancy (HM) may be at an even higher risk. We performed a retrospective analysis of patients with history of HM and acute COVID-19 to evaluate thrombotic and clinical outcomes. Patients with COVID-19 were identified by positive SARS-CoV-2 PCR test. Our primary endpoints were rate of VTE and CV...

Mental healthcare for children with chronic conditions: a qualitative study.
https://doi.org/10.1136/archdischild-2021-321795
Archives of Disease in Childhood; Jones R, Hiscock H et. al.

Jan 22nd, 2022 - To explore parent perspectives on accessing mental healthcare for children with a chronic physical health condition. Qualitative research using semistructured interviews and Framework Analysis. Rankings were used to select attributes for a Discrete Choice Experiment (DCE). Four specialty outpatient clinics (diabetes, epilepsy, bronchiectasis unrelated to cystic fibrosis and epidermolysis bullos...

Abdominal aortic aneurysm clinical practice guidelines: a methodological assessment usi...
https://doi.org/10.1136/bmjopen-2021-056750
BMJ Open; Tan KHM, Salim S et. al.

Jan 22nd, 2022 - Abdominal aortic aneurysm (AAA) clinical practice guidelines (CPGs) provide evidence-based information on patient management; however, methodological differences exist in the development of CPGs. This study examines the methodological quality of AAA CPGs using a validated assessment tool. Medline, EMBASE and online CPG databases were searched from 1946 to 31 October 2021. Full-text, English lan...

Diagnosis of a floppy neonate with misleading clues: unraveled as congenital hypomyelin...
https://doi.org/10.1136/bcr-2021-247555
BMJ Case Reports; Ravikumar S, Devi U et. al.

Jan 22nd, 2022 - Contactin-associated protein 1 (CNTNAP1)-related congenital hypomyelinating neuropathy (CHN) is a rare type of peripheral neuropathy and has a clinically heterogeneous presentation. We report a neonate with an atypical presentation in the form of global hypotonia, facial diparesis and partial response to neostigmine challenge test. There was no clinical improvement on initiation of anticholines...

Factors associated with access and approach to esophagectomy for cancer: a National Can...
https://doi.org/10.1007/s00464-022-09032-0 10.3390/medsci7100100 10.3748/wjg.v18.i45.6521 10.1002/jso.24592 10.3748/wjg.v10.i12.1834 10.1111/1759-7714.13311 10.1093/jnci/djr077 10.3322/caac.21492 10.1016/j.suronc.2017.06.002 10.20524/aog.2018.0252 10.1097/SLA.0b013e3181dd4e8c 10.1007/s11912-013-0374-9 10.1186/1471-2482-11-2 10.1016/j.athoracsur.2017.04.065 10.2147/OTT.S112105 10.1097/SLA.0000000000002171 10.1097/JTO.0b013e3182397751 10.1016/j.athoracsur.2018.11.065 10.1007/s11605-020-04653-z 10.1245/s10434-018-6374-0 10.1080/10705519809540087 10.3390/JPM11070640 10.1016/j.athoracsur.2018.08.039 10.1186/S12960-020-0448-3 10.1245/S10434-012-2807-3 10.18632/ONCOTARGET.16694 10.1016/S0003-4975(03)01202-5 10.1111/j.1572-0241.2004.04131.x 10.1371/journal.pone.0121928 10.1136/bmjopen-2017-020702 10.1002/cncr.29731
Surgical Endoscopy; Blears E, Fernando HC et. al.

Jan 22nd, 2022 - Minimally invasive esophagectomy (MIE) for esophageal cancer has been associated with decreased pain, less blood loss, and shorter hospital stay with comparable survival to open surgery. To date, there is minimal information regarding what factors are associated with access to MIE. The National Cancer Database (NCDB) was used to compare rates of MIE (either robotic or laparoscopic) and open eso...