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About 50,730 results

Structural elucidation of two novel degradants of lurasidone and their formation mechan...
https://doi.org/10.1002/jms.4871
Journal of Mass Spectrometry : JMS; Wang KC, Guo Q et. al.

Jun 24th, 2022 - Lurasidone is an antipsychotic drug clinically used for the treatment of schizophrenia and bipolar disorder. During a mechanism-based forced degradation study of lurasidone, two novel degradation products were observed under free radical-mediated oxidative (via AIBN) and solution photolytic conditions. The structures of the two novel degradants were identified through an approach combining HPLC...

Production of High-titer Recombinant Newcastle Disease Virus from Allantoic Fluid.
https://doi.org/10.3791/63817
Journal of Visualized Experiments : JoVE; Yates JGE, Leacy A et. al.

Jun 14th, 2022 - Newcastle disease virus (NDV), also known as avian orthoavulavirus serotype-1, is a negative sense, single-stranded RNA virus that has been developed both as an oncolytic virus and a viral-vectored vaccine. NDV is an attractive therapeutic and prophylactic agent due to its well-established reverse genetics system, potent immunostimulatory properties, and excellent safety profile. When administe...

Blood purification therapy in patients with severe COVID-19 requiring veno-venous ECMO ...
https://doi.org/10.1177/03913988221103287
The International Journal of Artificial Organs; Akil A, Ziegeler S et. al.

Jun 14th, 2022 - Patients with severe manifestations of COVID-19 might exhibit characteristics of a sepsis-like syndrome that can progress to multiple organ failure and ultimately death. Underlying mechanism have been explored and suggest a profound dysregulation of the immune system associated with hyperinflammation, hemodynamic instability and respiratory failure. Besides standard intensive care treatment, ap...

The Safety of Paxlovid in Hemodialysis Patients With Covid-19
https://clinicaltrials.gov/ct2/show/NCT05366192

Jun 14th, 2022 - This is a prospective, two arms (two stage) study. There will be include 20 subjects. The including criteria are 1.Understand the present study/Agree and sign informed consent; 2. Age is between 18 and 75 men or women at the screening; 3.Blood purification twice or three times/week, including hemodialysis, hemofiltration, hemodiafiltration, CRRT or hybrid blood purification; 4.Regular hemodialy...

How Do Experts From Germany Assess the Monkeypox Situation?
https://www.medscape.com/viewarticle/975311

Jun 9th, 2022 - As of May 27, the global number of cases of infection with the monkeypox virus had risen to 401, 21 of which were in Germany. No deaths have been reported to date in Europe, North America, Canada, or Australia, but there is a lot of uncertainty regarding the subject. At a press briefing by the Science Center Germany, experts provided an overview of the available knowledge and ventured a predict...

Linked-read whole-genome sequencing resolves common and private structural variants in ...
https://doi.org/10.1182/bloodadvances.2021006720
Blood Advances; Peña-Perez L, Frengen N et. al.

Jun 9th, 2022 - Multiple myeloma (MM) is an incurable and aggressive plasma cell malignancy characterized by a complex karyotype with multiple structural variants (SVs) and copy number variations (CNVs). Linked-read whole-genome sequencing (lrWGS) allows for refined detection and reconstruction of SVs by providing long-range genetic information from standard short-read sequencing. This makes lrWGS an attractiv...

Kawasaki disease shock syndrome with acute respiratory distress syndrome in a child: a ...
https://doi.org/10.1186/s12890-022-02007-w 10.1177/0009922817729483 10.1097/BOR.0000000000000818 10.4103/0366-6999.219151 10.1007/s00431-012-1879-1 10.1016/j.jmii.2013.06.005 10.1055/s-0035-1548814 10.1136/adc.88.10.940 10.1080/08035250600729118 10.1016/j.jccase.2016.02.003 10.1007/s10067-020-05222-0 10.1186/cc13859 10.1186/s12969-018-0303-4 10.1161/01.CIR.0000079166.93475.5F 10.1161/CIR.0000000000000484 10.1164/rccm.201703-0548ST 10.1097/PCC.0000000000000439 10.1016/j.chest.2016.06.006 10.1097/01.smj.0000182176.71475.a9
BMC Pulmonary Medicine; Liu J, Yang C et. al.

Jun 7th, 2022 - Kawasaki disease (KD) is an acute systemic vasculitis that may involve multiple organs. KD shock syndrome (KDSS) is a rare complication of KD. Pulmonary involvement is rare in KD; reports of patients with KD who develop KDSS and acute respiratory distress syndrome (ARDS) are extremely rare. A 2-year-old girl was brought to the emergency department with fever, cough and tachypnea. The patient wa...

Expression, Purification, and In Silico Characterization of Mycobacterium smegmatis Alt...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142298
Disease Markers; Singh RK, Jaiswal LK et. al.

Jun 1st, 2022 - Sigma factor B (SigB), an alternative sigma factor (ASF), is very similar to primary sigma factor SigA (σ 70) but dispensable for growth in both Mycobacterium smegmatis (Msmeg) and Mycobacterium tuberculosis (Mtb). It is involved in general stress responses including heat, oxidative, surface, starvation stress, and macrophage infections. Despite having an extremely short half-life, SigB tends t...

T405, a New Penem, Exhibits In Vivo Efficacy against M. abscessus and Synergy with β-La...
https://doi.org/10.1128/aac.00536-22
Antimicrobial Agents and Chemotherapy; Rimal B, Batchelder HR et. al.

Jun 1st, 2022 - Mycobacteroides abscessus (Mab) is an emerging environmental microbe that causes chronic lung disease in patients with compromised lung function such as cystic fibrosis and bronchiectasis. It is intrinsically resistant to most antibiotics, therefore there are only few antibiotics that can be repurposed to treat Mab disease. Although current recommendations require daily intake of multiple antib...

People Infected With Monkeypox Can Isolate at Home: UKHSA
https://www.medscape.com/viewarticle/974797

May 31st, 2022 - LONDON (Reuters) - People infected with monkeypox can isolate at home, if they remain well enough, whilst following measures to limit close contact with others, the UK's health security agency (UKHSA) said on Monday, as part of fresh guidance designed to curb the rise in cases of viral illness in the country. More than 300 suspected and confirmed cases of monkeypox - a usually mild illness that...

Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha ...
https://doi.org/10.1371/journal.pone.0268767
PloS One; Teng IT, Nazzari AF et. al.

May 25th, 2022 - Since the outbreak of the COVID-19 pandemic, widespread infections have allowed SARS-CoV-2 to evolve in human, leading to the emergence of multiple circulating variants. Some of these variants show increased resistance to vaccine-elicited immunity, convalescent plasma, or monoclonal antibodies. In particular, mutations in the SARS-CoV-2 spike have drawn attention. To facilitate the isolation of...

Characterization of a novel microfilarial antigen for diagnosis of Wuchereria bancrofti...
https://doi.org/10.1371/journal.pntd.0010407
PLoS Neglected Tropical Diseases; Greene SE, Fischer K et. al.

May 24th, 2022 - Lymphatic filariasis (LF) is a neglected tropical disease caused by the filarial nematodes Wuchereria bancrofti, Brugia malayi and Brugia timori. The Global Program to Eliminate LF uses mass drug administration (MDA) of anti-filarial drugs that clear microfilariae (Mf) from blood to interrupt transmission by mosquitos. New diagnostic tools are needed to assess the impact of MDA on bancroftian f...

ANTIMALARIAL activities and alkaloids from Crinum jagus (Thomps) DANDY.
https://doi.org/10.1016/j.jep.2022.115359
Journal of Ethnopharmacology; Akinyele ST, Elusiyan CA et. al.

May 24th, 2022 - Locally, among the Yoruba speaking people of South Western, Nigeria, the bulb of Crinum jagus (CJ), known as "ogede odo" is used to treat malaria and as an anthelmintic among other uses. Study aimed at identifying the purified active fractions and constituents of this fraction in an antiplasmodial activity-guided process. Antiplasmodial activity-guided fractionation of the bulb and leaf extract...

Monkeypox Quarantines Not Needed in US, Biden Says
https://www.medscape.com/viewarticle/974464

May 23rd, 2022 - President Joe Biden said Monday that he didn't believe quarantines to prevent the spread of monkeypox in the U.S. would be necessary. He said the U.S. has enough vaccine doses available to stop any serious outbreaks and to "deal with the likelihood of the problem," according to The Washington Post. "I just don't think it rises to the level of the kind of concern that existed with COVID-19, and ...

A call for an independent inquiry into the origin of the SARS-CoV-2 virus.
https://doi.org/10.1073/pnas.2202769119
Proceedings of the National Academy of Sciences of the Un... Harrison NL, Sachs JD

May 20th, 2022 - A call for an independent inquiry into the origin of the SARS-CoV-2 virus.|2022|Harrison NL,Sachs JD,|transmission,virology,virology,genetics,isolation & purification,

RNA in cancer immunotherapy: unlocking the potential of the immune system.
https://doi.org/10.1158/1078-0432.CCR-21-3304
Clinical Cancer Research : an Official Journal of the Ame... Mey W, Esprit A et. al.

May 19th, 2022 - Recent advances in the manufacturing, modification, purification and cellular delivery of ribonucleic acid (RNA) have enabled the development of RNA-based therapeutics for a broad array of applications. The approval of two SARS-CoV-2-targeting mRNA-based vaccines has highlighted the advances of this technology. Offering rapid and straightforward manufacturing, clinical safety and versatility, t...

Efficacy of Hemoperfusion in Severe and Critical Cases of COVID-19.
https://doi.org/10.1159/000524606
Blood Purification; Alavi Darazam I, Kazempour M et. al.

May 18th, 2022 - Uncontrolled overproduction of inflammatory mediators is predominantly observed in patients with severe COVID-19. The excessive immune response gives rise to multiple organ dysfunction. Implementing extracorporeal therapies may be useful in omitting inflammatory mediators and supporting different organ systems. We aimed to investigate the effectiveness of hemoperfusion in combination with stand...

Diurnal biting of malaria mosquitoes in the Central African Republic indicates residual...
https://doi.org/10.1073/pnas.2104282119
Proceedings of the National Academy of Sciences of the Un... Sangbakembi-Ngounou C, Costantini C et. al.

May 17th, 2022 - Malaria control interventions target nocturnal feeding of the Anopheles vectors indoors to reduce parasite transmission. Mass deployment of insecticidal bed nets and indoor residual spraying with insecticides, however, may induce mosquitoes to blood-feed at places and at times when humans are not protected. These changes can set a ceiling to the efficacy of these control interventions, resultin...

Development of a cost-effective ovine antibody-based therapy against SARS-CoV-2 infecti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075985
Antiviral Research; Findlay-Wilson S, Easterbrook L et. al.

May 10th, 2022 - Antibodies against SARS-CoV-2 are important to generate protective immunity, with convalescent plasma one of the first therapies approved. An alternative source of polyclonal antibodies suitable for upscaling would be more amendable to regulatory approval and widespread use. In this study, sheep were immunised with SARS-CoV-2 whole spike protein or one of the subunit proteins: S1 and S2. Once s...

Convergence between germline and somatic mutations in pancreatic neuroendocrine tumors.
https://doi.org/10.1530/EJE-21-0893
European Journal of Endocrinology; Ling C, Hong X et. al.

May 7th, 2022 - The pancreatic neuroendocrine tumors (PanNETs) are a group of clinically heterogeneous neoplasms. Although previous studies illustrated the somatic mutation pattern for PanNETs, the germline mutation pattern is still unclear. Here, we comprehensively screened the underlying germline mutations in a cohort of multiple endocrine neoplasia type 1 (MEN1)-related and sporadic PanNETs to reveal the ch...