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About 48,513 results

1 in 3 Still infectious After 5-Day COVID Quarantine
https://www.medscape.com/viewarticle/966640

Jan 14th, 2022 - Potentially active SARS-CoV-2 may persist beyond 10 days say researchers from the University of Exeter, facilitating onward transmission of COVID-19 after a person has completed the advised quarantine period. In their study, published in the International Journal of Infectious Diseases , the researchers evaluated associations between COVID-19 activity and active viral load, and characterised th...

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apher...
https://doi.org/10.12659/AJCR.935263
The American Journal of Case Reports; Schumann C, Heigl F et. al.

Jan 11th, 2022 - BACKGROUND Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced pneumonia is a disease with high mortality and, still, no effective treatment. Excessively elevated C-reactive protein (CRP) plasma levels inversely correlate with prognosis. As CRP, via complement and macrophage activation, can cause organ damage in COVID-19, we have recently introduced selective CRP apheresis as a...

Persistence of live virus in critically ill patients infected with SARS-COV-2: a prospe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724747
Critical Care (London, England); Funk DJ, Bullard J et. al.

Jan 6th, 2022 - Research on the duration of infectivity of ICU patients with COVID-19 has been sparse. Tests based on Reverse Transcriptase polymerase chain reaction (RT-PCR) detect both live virus and non-infectious viral RNA. We aimed to determine the duration of infectiousness based on viral culture of nasopharyngeal samples of patients with COVID-19. Prospective observational study in adult intensive care ...

CDC's Isolation Guidelines Are Inadequate
https://www.medscape.com/viewarticle/966003

Jan 5th, 2022 - The CDC has just shortened recommended isolation times for COVID-19 for people who are asymptomatic from 10 days to 5. They still advise that masks be worn. Similarly, they advise unvaccinated people exposed to COVID to only quarantine for 5 days, followed by wearing a mask for an additional 5 days. Those who have received boosters no longer need to isolate but are still advised to wear masks f...

A threshold-free approach with age-dependency for estimating malaria seroprevalence.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725324
Malaria Journal; Kyomuhangi I, Giorgi E

Jan 5th, 2022 - In malaria serology analysis, the standard approach to obtain seroprevalence, i.e the proportion of seropositive individuals in a population, is based on a threshold which is used to classify individuals as seropositive or seronegative. The choice of this threshold is often arbitrary and is based on methods that ignore the age-dependency of the antibody distribution. Using cross-sectional antib...

The evaluation of the utility of the GENECUBE HQ SARS-CoV-2 for anterior nasal samples ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719657
PloS One; Naito A, Kiyasu Y et. al.

Jan 1st, 2022 - GENECUBE® is a rapid molecular identification system, and previous studies demonstrated that GENECUBE® HQ SARS-CoV-2 showed excellent analytical performance for the detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) with nasopharyngeal samples. However, other respiratory samples have not been evaluated. This prospective comparison between GENECUBE® HQ SARS-CoV-2 and refer...

Investigation of a SARS-CoV-2 B.1.1.529 (Omicron) Variant Cluster - Nebraska, November-...
https://doi.org/10.15585/mmwr.mm705152e3
MMWR. Morbidity and Mortality Weekly Report; Jansen L, Tegomoh B et. al.

Dec 31st, 2021 - The B.1.1.529 (Omicron) variant of SARS-CoV-2 (the virus that causes COVID-19) was first detected in specimens collected on November 11, 2021, in Botswana and on November 14 in South Africa;* the first confirmed case of Omicron in the United States was identified in California on December 1, 2021 (1). On November 29, the Nebraska Department of Health and Human Services was notified of six proba...

Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726722
Gut Microbes; Sencio V, Machelart A et. al.

Dec 30th, 2021 - Mounting evidence suggests that the gut-to-lung axis is critical during respiratory viral infections. We herein hypothesized that disruption of gut homeostasis during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may associate with early disease outcomes. To address this question, we took advantage of the Syrian hamster model. Our data confirmed that this model recapitu...

The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711289
Virology Journal; Zeng XT, Yu XT et. al.

Dec 29th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein determines virus entry and the palmitoylation of S protein affects virus infection. An acyltransferase complex ZDHHC5/GOGAL7 that interacts with S protein was detected by affinity purification mass spectrometry (AP-MS). However, the palmitoylated cysteine residues of S protein, the effects of ZDHHC5 or GOLGA7 knockou...

Bioactive triterpenoids from Solanum torvum fruits with antifungal, resistance modulato...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714089
PloS One; Harley BK, Neglo D et. al.

Dec 29th, 2021 - Vulvovaginal candidiasis (VVC) is the second most common vaginal infection that affects women of reproductive age. Its increased occurrence and associated treatment cost coupled to the rise in resistance of the causative pathogen to current antifungal therapies has necessitated the need for the discovery and development of novel effective antifungal agents for the treatment of the disease. We r...

Evaluation of effect of empirical attack-preventive immunotherapies in neuromyelitis op...
https://doi.org/10.1016/j.jneuroim.2021.577790
Journal of Neuroimmunology; Ma J, Yu H et. al.

Dec 28th, 2021 - Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system, which mainly involves the optic nerve and spinal cord. Frequent relapse can accumulate the degree of disability. At present, the main treatment options are immunosuppressants and blood purification. The first-line immunosuppressants for NMOSD are mainly rituximab (RTX), mycophenolate mofetil...

Neglected malaria parasites in hard-to-reach areas of Odisha, India: implications in el...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698664
Malaria Journal; Bal M, Rana R et. al.

Dec 25th, 2021 - Information on the foci of Plasmodium species infections is essential for any country heading towards elimination. Odisha, one of the malaria-endemic states of India is targeting elimination of malaria by 2030. To support decision-making regarding targeted intervention, the distribution of Plasmodium species infections was investigated in hard-to-reach areas where a special malaria elimination ...

EBV+ ALK+ large B-cell lymphoma.
https://doi.org/10.1182/blood.2021013595
Blood Liu H, Hu S

Dec 24th, 2021 - EBV+ ALK+ large B-cell lymphoma.|2021|Liu H,Hu S,|analysis,complications,pathology,isolation & purification,pathology,virology,pathology,virology,

Monitoring International Travelers Arriving in Hong Kong for Genomic Surveillance of SA...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714226
Emerging Infectious Diseases; Gu H, Cheng SSM et. al.

Dec 22nd, 2021 - We sequenced ≈50% of coronavirus disease cases imported to Hong Kong during March-July 2021 and identified 70 cases caused by Delta variants of severe acute respiratory syndrome coronavirus 2. The genomic diversity detected in Hong Kong was similar to global diversity, suggesting travel hubs can play a substantial role in surveillance.

Evidence of co-circulation of multiple arboviruses transmitted by Aedes species based o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684590
Parasites & Vectors; Rufalco-Moutinho P, de Noronha LAG et. al.

Dec 21st, 2021 - Vector-borne diseases, especially arboviruses transmitted by Aedes sp. mosquitos, should be a health policy priority in Brazil. Despite this urgency, there are significant limitations in the traditional surveillance system, mainly in vulnerable areas. This study aimed to investigate the circulation of dengue (DENV), Zika (ZIKV), and chikungunya viruses (CHIKV) by laboratory syndromic surveillan...

Neurological infection by chikungunya and a triple Arbovirus co-infection in Mato Gross...
https://doi.org/10.1016/j.jcv.2021.105056
Journal of Clinical Virology : the Official Publication O... Pavon JAR, Neves NADS et. al.

Dec 20th, 2021 - Neurological viral infection is frequently associated to enterovirus, herpesvirus and arboviruses. These infections may cause severe clinical outcomes, long lasting sequelae or death. Few studies have addressed viral neurological infections etiology in Brazil. Identification of viruses in the cerebral spinal fluid (CSF) of human neurological infections suspected of viral etiology during January...

Performance Accuracy of a Laboratory-Developed Real-Time RT-PCR Method for Detection of...
https://www.ncbi.nlm.nih.gov/pubmed/34921026
Annals of Clinical and Laboratory Science; Hata DJ, White EL et. al.

Dec 19th, 2021 - The ongoing COVID-19 pandemic caused by SARS-CoV-2 has challenged diagnostic laboratories to re-examine traditional methods for collecting specimens and sample types used in molecular testing. Our goal was to demonstrate that saliva can be used for detecting SARS-CoV-2 and correlates well with established molecular methods using nasopharyngeal (NP) swabs. We examined use of a saliva collection ...

Establishment of a quantitative RT-PCR detection of SARS-CoV-2 virus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677905
European Journal of Medical Research; Jiang Y, Zhang S et. al.

Dec 19th, 2021 - The outbreak of novel coronavirus disease 2019 (COVID-19) has become a public health emergency of international concern. Quantitative testing of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus is demanded in evaluating the efficacy of antiviral drugs and vaccines and RT-PCR can be widely deployed in the clinical assay of viral loads. Here, we developed a quantitative RT-PCR m...

Epidemiological profile of multidrug-resistant and extensively drug-resistant Mycobacte...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684270
Annals of Clinical Microbiology and Antimicrobials; Elion Assiana DO, Abdul JBPA et. al.

Dec 19th, 2021 - There is paucity of data on the prevalence and distribution of multidrug- Resistant-Tuberculosis (MDR-TB) in the Republic of Congo. Among the challenges resides the implementation of a robust TB resistance diagnostic program using molecular tools. In resource limited settings there is a need to gather data to enable prioritization of actions. The objective of this study was is to implement mole...

Prevalence of SARS-CoV-2 amongst ophthalmologists throughout the first and second waves...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677999
Medicine Sacchi M, Lizzio RAU et. al.

Dec 18th, 2021 - The study aims to investigate the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among ophthalmology unit staff throughout the first and second waves of the outbreak, in order to verify the effectiveness of the measures adopted in containing the contagion.A retrospective observational study was conducted involving staff members, who received a naso/orophary...