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About 360,803 results

Molecular Modelling Predicts Inhibition of Functional Effects of Anti-thrombin III on Factor Xa Mediated Complement Activation by Anti- Factor Xa IgG in SLE and APS
https://acrabstracts.org/abstract/molecular-modelling-predicts-inhibition-of-functional-effects-of-anti-thrombin-iii-on-factor-xa-mediated-complement-activation-by-anti-factor-xa-igg-in-sle-and-aps/
Thomas McDonnell, Raj Amarnani, Valentina Spiteri et. al.

Nov 9th, 2021 - Background/Purpose: The significance of antibodies directed against activated Factor (FXa) and thrombin (Thr) found in ~40% of patients with Systemic Lupus Erythematosus (SLE) and/or Antiphospholipid Syndrome (APS) has not been determined. FXa and Thr are both co-regulated by antithrombin (AT)III and increasingly implicated in alternative pathways of complement activation. Therefore, we studied...

Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgeho...
https://doi.org/10.1186/s12943-021-01435-2 10.1038/nrc4017 10.3322/caac.21262 10.1056/NEJMoa0901282 10.1038/nature09781 10.1038/nature12624 10.1016/j.stem.2014.02.006 10.3748/wjg.v22.i13.3547 10.1007/s11864-018-0533-1 10.1038/nrclinonc.2015.61 10.1136/gutjnl-2015-310625 10.1016/j.stem.2015.03.003 10.1016/j.jhep.2018.12.015 10.1038/nsmb.3235 10.15252/embj.2018101110 10.1016/j.molcel.2015.03.027 10.1016/j.cell.2019.03.046 10.1016/j.immuni.2018.03.016 10.1002/hep.30795 10.1186/s12943-020-01184-8 10.1038/nrm.2016.111 10.1073/pnas.92.19.8861 10.1186/1476-4598-12-119 10.1016/j.jhep.2018.03.029 10.1038/s41556-018-0194-0 10.1038/ncomms13608 10.1080/15476286.2016.1269999 10.1080/15384101.2017.1346754 10.1038/nature13305 10.15252/embj.2018100836 10.1016/j.ccell.2015.11.007 10.1146/annurev-cellbio-092910-154048 10.1016/j.cell.2014.02.057 10.1126/science.aad7993 10.1038/nsmb.2517 10.1038/nm0909-1010 10.1016/j.cell.2014.09.001 10.1038/nrg.2016.114 10.1186/s12943-020-01246-x 10.1038/nsmb.2959 10.1038/s41580-020-0243-y 10.1083/jcb.201604025 10.1038/nature11715 10.1038/nrm831 10.1016/j.molcel.2010.11.022 10.1093/nar/gks779 10.3892/ol.2018.9746 10.1038/s41467-018-05220-6 10.1038/s41419-019-1946-x 10.1186/s12943-018-0935-5 10.1016/j.neuron.2012.05.009 10.1016/S1474-4422(13)70061-9
Molecular Cancer; Gu Y, Wang Y et. al.

Oct 16th, 2021 - Hepatocellular carcinoma (HCC) is one of the most intractable tumors in the world due to its high rate of recurrence and heterogeneity. Liver cancer initiating cells also called cancer stem cells (CSCs) play a critical role in resistance against typical therapy and high tumor-initiating potential. However, the role of the novel circular RNA (circRNA) circIPO11 in the maintenance of liver cancer...

Improved Methods of Cell Selection for Bone Marrow Transplant Alternatives
https://clinicaltrials.gov/ct2/show/NCT00001529

Oct 15th, 2021 - The NHLBI Stem Cell Transplantation program is exploring ways to make allogeneic transplantation safer and more widely applicable. Prior NHLBI transplant protocols have evaluated the strategy of using T cell depleted marrow transplants followed by delayed lymphocyte add-back to control or prevent GVHD while conserving useful donor immune function against residual leukemia and infectious agents....

Neutrophil-to-Lymphocyte Ratio and Erythropoietin Resistance among Maintenance Hemodial...
https://doi.org/10.1159/000519644
Blood Purification; Zhang J, Lu X et. al.

Oct 15th, 2021 - Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are recent prognostic biomarkers associated with inflammation. Increased erythropoiesis resistance index (ERI) may predict the risk of all-cause and cardiovascular mortality in hemodialysis (HD) patients. However, the roles of NLR and PLR in erythropoietin (EPO) responsiveness remain unclear in HD patients. This study aims to...

Reassessment of the proteomic composition and function of extracellular vesicles in the...
https://doi.org/10.1210/endocr/bqab214
Endocrinology Wang H, Zhu Y et. al.

Oct 15th, 2021 - Seminal plasma contains a high concentration of extracellular vesicles (EVs). The heterogeneity of small EVs or the presence of non-vesicular extracellular matter (NV) pose major obstacles in understanding the composition and function of seminal EVs. In this study, we employed high-resolution density gradient fractionation to accurately characterize the composition and function of seminal EVs a...

Use of extracorporeal blood purification therapy (ECBPT) as an adjuvant to high-dose co...
https://doi.org/10.1136/bcr-2021-245639
BMJ Case Reports; Lim MX, Fong KK et. al.

Oct 15th, 2021 - COVID-19 presents with a spectrum of severity, ranging from asymptomatic or mild symptoms to those with acute respiratory distress syndrome. Corticosteroids are widely used for their efficacy in reducing inflammatory responses. However, its use may be limited to patients with immunosuppression. An adjunct therapy for cytokine storm in COVID-19 is extracorporeal blood purification therapies usin...

Minimising exposure to respiratory droplets, 'jet riders' and aerosols in air-condition...
https://doi.org/10.1136/bmjopen-2020-047772
BMJ Open; Hunziker P

Oct 14th, 2021 - In COVID-19, transfer of respiratory materials transmits disease and drives the pandemic but the interplay of droplet and aerosol physics, physiology and environment is not fully understood. To advance understanding of disease transmission mechanisms and to find novel exposure minimisation strategies, we studied cough-driven material transport modes and the efficacy of control strategies. Compu...

Influence of Early-Onset Peritonitis on Mortality and Clinical Outcomes in ESRD Patient...
https://doi.org/10.1159/000514938
Blood Purification; Guo Q, Chen Y et. al.

Oct 13th, 2021 - The impact of early-onset peritonitis (EOP) on patients with diabetes undergoing peritoneal dialysis (PD) has not been adequately addressed. We therefore sought to investigate the effects of EOP on the therapeutic response to management and long-term prognostic outcomes in patients with diabetes undergoing PD. For this retrospective cohort study, we analyzed the data for patients with end-stage...

Oxidative stress-mediated particulate matter affects the risk of relapse in schizophren...
https://doi.org/10.1016/j.envpol.2021.118348
Environmental Pollution (Barking, Essex : 1987); Wei Q, Ji Y et. al.

Oct 13th, 2021 - Particulate matter (PM) exposure increased the risk of hospital admission and was related to symptoms of schizophrenia (SCZ). However, there are limited studies on the relationship between PM exposure and SCZ relapse risk, and the underlying biological mechanisms remain unclear. We designed an air purification intervention study under a 16-day real air purifier scenario and another 16-day sham ...

Hemoperfusion and blood purification strategies in patients with COVID-19: A systematic...
https://doi.org/10.1111/aor.14078
Artificial Organs; Sanfilippo F, Martucci G et. al.

Oct 12th, 2021 - Coronavirus disease-19 (COVID-19) ranges from asymptomatic infection to severe cases requiring admission to the intensive care unit. Together with supportive therapies (ventilation in particular), the suppression of the pro-inflammatory state has been a hypothesized target. Pharmacological therapies with corticosteroids and interleukin-6 (IL-6) receptor antagonists have reduced mortality. The u...

Radiosynthesis of 1-(2-18FFluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol.
https://doi.org/10.3791/63025
Journal of Visualized Experiments : JoVE; Yue X, Nikam RM et. al.

Oct 12th, 2021 - The kynurenine pathway (KP) is a primary route for tryptophan metabolism. Evidence strongly suggests that metabolites of the KP play a vital role in tumor proliferation, epilepsy, neurodegenerative diseases, and psychiatric illnesses due to their immune-modulatory, neuro-modulatory, and neurotoxic effects. The most extensively used positron emission tomography (PET) agent for mapping tryptophan...

The effects of blood purification combined with antibiotics on extravascular lung water...
https://doi.org/10.21037/apm-21-2168
Annals of Palliative Medicine; Xu BQ, Zhou Y

Oct 12th, 2021 - To retrospectively analyze the effects of routine treatment and blood purification combined with antibiotics on the extravascular lung water index (EVLWI), inflammatory factors, and treatment outcomes in patients with severe acute pancreatitis (SAP) complicated with acute respiratory distress syndrome (ARDS). A total of 131 SAP patients admitted to the intensive care unit of Suzhou Ninth Hospit...

Telomere-specific chromatin capture using a pyrrole-imidazole polyamide probe for the i...
https://doi.org/10.1186/s13072-021-00421-8 10.1016/j.cell.2020.09.014 10.1101/cshperspect.a040675 10.1016/S0092-8674(00)81979-0 10.1016/j.cell.2007.05.022 10.1038/nature09819 10.1016/0092-8674(89)90035-4 10.1126/science.1689074 10.1126/science.1147182 10.1073/pnas.1113536108 10.1016/j.molcel.2011.08.027 10.1126/science.1237973 10.1038/s41592-020-0765-4 10.1016/j.cell.2008.11.045 10.1038/ncomms7674 10.1038/ncomms3848 10.1038/srep03171 10.1016/j.cell.2017.08.003 10.1073/pnas.1718844115 10.1093/emboj/20.12.3218 10.1021/ja406737n 10.1021/ja506058e 10.1039/C4SC03755C 10.1021/jacs.6b09023 10.1016/j.bmc.2018.01.026 10.1021/jacs.0c04955 10.1246/bcsj.20190311 10.1038/382559a0 10.1038/35106 10.1073/pnas.0906532106 10.1016/S0968-0896(01)00262-0 10.1016/S0959-440X(03)00081-2 10.2174/1568011054222346 10.1021/ar030287f 10.1016/j.bmc.2013.04.023 10.1038/srep29261 10.1038/337331a0 10.1002/anie.201002387 10.1016/j.tcb.2014.08.007 10.1016/j.jmb.2020.03.003 10.1126/sciadv.aav3673 10.1038/ncb1685 10.1101/gr.1245004 10.1038/ncomms5723 10.1261/rna.076281.120 10.1007/s00412-017-0656-3 10.1080/15476286.2015.1065374 10.1016/j.cell.2017.06.006 10.1593/neo.131574 10.1016/j.cell.2015.01.044 10.1038/s41467-019-13824-9 10.1016/j.bbrc.2015.09.176 10.1261/rna.1748309 10.1248/bpb.b13-00135 10.1016/j.cub.2017.01.011 10.1038/nbt.3968 10.7554/eLife.27024 10.1038/s41467-020-14337-6 10.1038/35057062 10.1016/j.ceb.2020.02.016 10.1016/j.sbi.2021.06.004 10.1038/nmeth.2019 10.1038/ng1952 10.1093/nar/gkt1117 10.1074/jbc.M109.038026 10.14806/ej.17.1.200 10.1093/bioinformatics/btr026 10.1038/nmeth.3317 10.1038/nbt.1621 10.1093/bioinformatics/btt656 10.1093/bib/bbs017 10.1038/nmeth.1923 10.1073/pnas.1423819112
Epigenetics & Chromatin; Ide S, Sasaki A et. al.

Oct 11th, 2021 - Knowing chromatin components at a DNA regulatory element at any given time is essential for understanding how the element works during cellular proliferation, differentiation and development. A region-specific chromatin purification is an invaluable approach to dissecting the comprehensive chromatin composition at a particular region. Several methods (e.g., PICh, enChIP, CAPTURE and CLASP) have...

Rapid and inexpensive purification of adenovirus vectors using an optimised aqueous two...
https://doi.org/10.1016/j.jviromet.2021.114305
Journal of Virological Methods; Suleman S, Schrubaji K et. al.

Oct 10th, 2021 - Adenoviruses (AdVs) are used as gene therapy vectors to treat human diseases and as vaccines against COVID-19. AdVs are produced by transfecting human embryonic kidney 239 (HEK293) or PER.C6 virus producer cells with AdV plasmid vectors or infecting these cells withcell lysates containing replication-defective AdV. Cell lysates can be purified further by caesium chloride or chromatographic prot...

Immunotherapy of multisystem inflammatory syndrome in children (MIS-C) following COVID-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487784
International Immunopharmacology; Suksatan W, Chupradit S et. al.

Oct 10th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new type of coronavirus causing coronavirus 2019 (COVID-19) that was first observed in Wuhan, China, in Dec. 2019. An inflammatory immune response targeting children appeared during the pandemic, which was associated with COVID-19 named multisystem inflammatory syndrome in children (MIS-C). Characteristics of MIS-C include the cl...

Structure-controllable growth of nitrogenated graphene quantum dots via solvent catalys...
https://doi.org/10.1038/s41467-021-26122-0 10.1039/C7CS00235A 10.1002/adfm.201501250 10.1002/adma.201904362 10.1002/adma.201305299 10.1039/C6TB03067J 10.1002/anie.201311248 10.1038/s41565-018-0179-y 10.1016/j.nanoen.2017.02.013 10.1021/acs.chemmater.5b04915 10.1039/C4NR06365A 10.1039/c3tc30820k 10.1039/C7TC02434G 10.1039/C4TC01139B 10.1002/adfm.201603803 10.1016/j.jcis.2019.01.099 10.1039/C5TC00813A 10.1002/advs.201801432 10.1021/acsnano.9b09554 10.1002/adfm.201804337 10.1039/C5RA07745A 10.1039/c3nr04402e 10.1021/nn300760g 10.1002/anie.202000579 10.1002/poc.1316 10.1021/nl2038979 10.1002/chem.201903877 10.1039/c3cp53740d 10.1039/c3ta11870c 10.1016/0022-2313(96)00008-7 10.1016/0301-0104(91)87062-Z 10.1039/c3dt52465e 10.1039/C6CP05609A 10.1021/ja01496a011 10.1021/j100062a014 10.1038/nrrheum.2012.143 10.1056/NEJMra0800885 10.1063/1.447964 10.1073/pnas.82.20.6723 10.1021/acssuschemeng.5b00771 10.1021/cs200652y 10.1126/science.aad0832 10.1021/jp953720e 10.1039/C3RA45591B 10.1039/C5TC00250H
Nature Communications; Moon BJ, Kim SJ et. al.

Oct 9th, 2021 - Photophysical and photochemical properties of graphene quantum dots (GQDs) strongly depend on their morphological and chemical features. However, systematic and uniform manipulation of the chemical structures of GQDs remains challenging due to the difficulty in simultaneous control of competitive reactions, i.e., growth and doping, and the complicated post-purification processes. Here, we repor...

Surgical approach and short-term outcomes in adults and children undergoing total pancr...
https://doi.org/10.1016/j.pan.2021.09.011
Pancreatology : Official Journal of the International Ass... Nathan JD, Yang Y et. al.

Oct 9th, 2021 - Total pancreatectomy with islet autotransplantation (TPIAT) is a viable option for treating debilitating recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) in adults and children. No data is currently available regarding variation in approach to operation. We evaluated surgical techniques, islet isolation and infusion approaches, and outcomes and complications, comparing children ...

A refractory human T-cell leukemia virus type 1-associated myelopathy/tropical spastic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500642
Medicine Tamaki K, Mera H et. al.

Oct 9th, 2021 - Adult T-cell leukemia/lymphoma (ATL) and human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are caused by HTLV-1, but the coexistence of both disorders is rare. The estimated incidence is approximately 3%. A 54-year-old man was unable to stand up because of spastic paraparesis 1 month after the onset. He developed lymphadenopathy in the left...

Staging of human papilloma virus related cancers of the oropharynx.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514047
Journal of Surgical Oncology; Valero C, Shah JP

Oct 9th, 2021 - For the past two decades an increasing number of oropharyngeal cancers have been found to be associated with the human papilloma virus (HPV). These tumors are a biologically distinct entity with better prognosis and excellent response to therapy. Therefore, a separate staging system has been introduced for HPV-related oropharyngeal tumors in the latest edition of the American Joint Committee on...

Distribution of SARS-CoV-2 Variants in a Large Integrated Health Care System - Californ...
https://doi.org/10.15585/mmwr.mm7040a4
MMWR. Morbidity and Mortality Weekly Report; Malden DE, Bruxvoort KJ et. al.

Oct 8th, 2021 - Data from observational studies demonstrate that variants of SARS-CoV-2, the virus that causes COVID-19, have evolved rapidly across many countries (1,2). The SARS-CoV-2 B.1.617.2 (Delta) variant of concern is more transmissible than previously identified variants,* and as of September 2021, is the predominant variant in the United States.† Studies characterizing the distribution and severity o...