About 1,445 results

Travel measures in the SARS-CoV-2 variant era need clear objectives.
Lancet (London, England); Kucharski AJ, Jit M et. al.

Mar 6th, 2022 - Travel measures in the SARS-CoV-2 variant era need clear objectives.|2022|Kucharski AJ,Jit M,Logan JG,Cotten M,Clifford S,|epidemiology,genetics,legislation & jurisprudence,

Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmi...
Nature Communications; Aggarwal D, Page AJ et. al.

Feb 25th, 2022 - Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the...

Preventing SARS-CoV-2 Transmission in Health Care Settings in the Context of the Omicro...
JAMA Klompas M, Karan A

Jan 25th, 2022 - Preventing SARS-CoV-2 Transmission in Health Care Settings in the Context of the Omicron Variant.|2022|Klompas M,Karan A,|epidemiology,transmission,epidemiology,prevention & control,prevention & control,prevention & control,legislation & jurisprudence,pathogenicity,

Model-based evaluation of alternative reactive class closure strategies against COVID-19.
Nature Communications; Liu QH, Zhang J et. al.

Jan 16th, 2022 - There are contrasting results concerning the effect of reactive school closure on SARS-CoV-2 transmission. To shed light on this controversy, we developed a data-driven computational model of SARS-CoV-2 transmission. We found that by reactively closing classes based on syndromic surveillance, SARS-CoV-2 infections are reduced by no more than 17.3% (95%CI: 8.0-26.8%), due to the low probability ...

Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development.
Annals of Neurology; Paganoni S, Berry JD et. al.

Dec 23rd, 2021 - Current therapeutic development in amyotrophic lateral sclerosis (ALS) relies on individual randomized clinical trials to test a specific investigational product in a single patient population. This approach has intrinsic limitations, including cost, time, and lack of flexibility. Adaptive platform trials represent a novel approach to investigate several interventions for a single disease in a ...

Spatial Clustering of Vaccine Exemptions on the Risk of a Measles Outbreak.
Pediatrics Gromis A, Liu KY

Dec 7th, 2021 - Areas of increased school-entry vaccination exemptions play a key role in epidemics of vaccine-preventable diseases in the United States. California eliminated nonmedical exemptions in 2016, which increased overall vaccine coverage but also rates of medical exemptions. We examine how spatial clustering of exemptions contributed to measles outbreak potential pre- and postpolicy change. We modele...

Another Monoclonal Antibody Granted EUA to treat COVID-19.
The American Journal of Nursing; Aschenbrenner DS

Nov 26th, 2021 - The Food and Drug Administration has granted emergency use authorization to sotrovimab for the treatment of mild to moderate COVID-19 in patients at increased risk for progression to severe illness.Sotrovimab is a monoclonal antibody that works directly against the spike protein of SARS-CoV-2 to block its attachment and entry into a human cell.

How an outbreak became a pandemic: a chronological analysis of crucial junctures and in...
Lancet (London, England); Singh S, McNab C et. al.

Nov 12th, 2021 - Understanding the spread of SARS-CoV-2, how and when evidence emerged, and the timing of local, national, regional, and global responses is essential to establish how an outbreak became a pandemic and to prepare for future health threats. With that aim, the Independent Panel for Pandemic Preparedness and Response has developed a chronology of events, actions, and recommendations, from December,...

Sexuality Among Adolescents With Intellectual Disability: Balancing Autonomy and Protec...
Pediatrics Enujioke SC, Leland B et. al.

Oct 30th, 2021 - Adolescents and young adults living with intellectual disability (ID) have made significant advancements integrating into multiple aspects of western society, but there has been less progress with regards to sexual health. While advocating for individuals with ID to live life to the fullest, pediatricians have practical concerns regarding the ability to consent to sex as well as avoid coercion ...

Twenty Years After the Anthrax Terrorist Attacks of 2001: Lessons Learned and Unlearned...
JAMA Gostin LO, Nuzzo JB

Oct 28th, 2021 - Twenty Years After the Anthrax Terrorist Attacks of 2001: Lessons Learned and Unlearned for the COVID-19 Response.|2021|Gostin LO,Nuzzo JB,|history,history,prevention & control,prevention & control,legislation & jurisprudence,history,trends,

Why Vaccine and Mask Mandates Hold Up in Court

Oct 12th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. President Joe Biden's announcement in September that large companies will soon be required to mandate COVID-19 vaccines or weekly testing for employees set off a domino effect of legal challenges in various states. Court cases began to crop up even before that when mask mandates came into play. ...

Genomics, social media and mobile phone data enable mapping of SARS-CoV-2 lineages to i...
Nature Microbiology; Cowley LA, Afrad MH et. al.

Sep 10th, 2021 - Genomics, combined with population mobility data, used to map importation and spatial spread of SARS-CoV-2 in high-income countries has enabled the implementation of local control measures. Here, to track the spread of SARS-CoV-2 lineages in Bangladesh at the national level, we analysed outbreak trajectory and variant emergence using genomics, Facebook 'Data for Good' and data from three mobile...

Association of Jail Decarceration and Anticontagion Policies With COVID-19 Case Growth ...
JAMA Network Open; Reinhart E, Chen DL

Sep 3rd, 2021 - Mass incarceration is known to foster infectious disease outbreaks, amplification of infectious diseases in surrounding communities, and exacerbation of health disparities in disproportionately policed communities. To date, however, policy interventions intended to achieve epidemic mitigation in US communities have neglected to account for decarceration as a possible means of protecting public ...

ROP Risk Management 2021.
Current Opinion in Ophthalmology; Gold RS

Aug 17th, 2021 - It is important for ophthalmologists to keep current with up-to-date recommendations for screening, treating, and follow-up of infants with retinopathy of prematurity (ROP). This paper will review updated ROP Safety Net protocols and Policy Statements to stress that following risk management principles can avoid claims that could arise from poor visual outcomes. Ophthalmic Mutual Insurance Comp...

Physician-hastened death in California for patients with amyotrophic lateral sclerosis:...
Muscle & Nerve; Grogan J, Simmons Z

Aug 10th, 2021 - Physician-hastened death in California for patients with amyotrophic lateral sclerosis: Part of a bigger picture.|2021|Grogan J,Simmons Z,|diagnosis,epidemiology,therapy,epidemiology,legislation & jurisprudence,legislation & jurisprudence,methods,

Mental health and quality of life for people with rheumatoid arthritis or ankylosing sp...
Rheumatology International; Johnstone G, Treharne GJ et. al.

Jul 24th, 2021 - The aim of this study was to investigate the effects of lockdown on the mental health (anxiety and depression) and quality of life (QOL) of people with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) in the context of the COVID-19 pandemic and public health measures instituted at a national level by the New Zealand Government. The present cohort was 104 individuals with RA (73.1%) and...

Huge gaps in detection networks plague emissions monitoring.
https://doi.org/10.1038/d41586-021-01967-z 10.1038/s41586-018-0106-2 10.1038/s41586-019-1193-4 10.1038/d41586-019-02109-2 10.1038/s41586-021-03260-5 10.1038/s41586-021-03277-w
Nature Weiss RF, Ravishankara AR et. al.

Jul 21st, 2021 - Huge gaps in detection networks plague emissions monitoring.|2021|Weiss RF,Ravishankara AR,Newman PA,|chemistry,analysis,legislation & jurisprudence,methods,standards,analysis,chemistry,analysis,chemistry,analysis,

Should SARS-CoV-2 vaccination for all frontline healthcare staff be compulsory?
British Journal of Nursing (Mark Allen Publishing); Glasper A

Jul 13th, 2021 - Emeritus Professor Alan Glasper, from the University of Southampton, discusses the issues raised by the recent government decision to make vaccination against the virus causing COVID-19 mandatory for care home staff.

Using real world data to support regulatory approval of drugs in rare diseases: A revie...
Current Problems in Cancer; Gross AM

Jul 13th, 2021 - Conducting clinical research in patients with rare diseases presents a variety of challenges. At the same time, rare diseases represent a large area of unmet medical need with a significant burden of morbidity throughout the world. One of the most common issues with designing clinical trials for rare disease populations is that the gold-standard randomized controlled trial design is often not f...

Causal inference multiple imputation investigation of the impact of cannabinoids and ot...
BMC Pharmacology & Toxicology; Reece AS, Hulse GK

Jul 12th, 2021 - Ethnic differences in testicular cancer rates (TCRs) are recognized internationally. Cannabis is a known risk factor for testicular cancer (TC) in multiple studies with dose-response effects demonstrated, however the interaction between ancestral and environmental mutagenic effects has not been characterized. We examined the effects of this presumed gene-environment interaction across US states...