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About 874,323 results

SARS-CoV-2 vaccine protection and deaths among US veterans during 2021
https://www.science.org/doi/10.1126/science.abm0620
Science Cohn BA, .

Nov 4th, 2021 - The messenger RNA vaccines BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna) and the viral vector vaccine JNJ-78436735 (Janssen) have effectively prevented clinically significant disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since their rollout in the U.S. in late 2020 (1, 2).

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Clinical Edge Journal Scan Commentary: PsA December 2021
https://www.mdedge.com/rheumatology/article/249458/psoriatic-arthritis/clinical-edge-journal-scan-commentary-psa-december
Vinod Chandran, MBBS, MD, DM, PhD

Dec 4th, 2021 - Vinod Chandran, MBBS, MD, DM, PhD Research published in November has provided us with insights on the impact of psoriatic arthritis (PsA) as well as treatment outcomes. Although PsA often affects women of child-bearing age, data on pregnancy outcomes in PsA is scarce.

Idiopathic inflammatory myopathies.
https://doi.org/10.1038/s41572-021-00321-x 10.1101/494062 10.1093/rheumatology/keab492
Nature Reviews. Disease Primers; Lundberg IE, Fujimoto M et. al.

Dec 4th, 2021 - Idiopathic inflammatory myopathies (IIM), also known as myositis, are a heterogeneous group of autoimmune disorders with varying clinical manifestations, treatment responses and prognoses. Muscle weakness is usually the classical clinical manifestation but other organs can be affected, including the skin, joints, lungs, heart and gastrointestinal tract, and they can even result in the predomina...

CTRP9 Mitigates the Progression of Arteriovenous Shunt-Induced Pulmonary Artery Hyperte...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598355
Cardiovascular Therapeutics; Guan H, Yang X et. al.

Dec 4th, 2021 - The present study is aimed at investigating the molecular mechanism of C1q/TNF-related protein 9 (CTRP9) and providing a new perspective in arteriovenous shunt-induced pulmonary arterial hypertension (PAH). PAH was established by an arteriovenous shunt placement performed in rats. Adenovirus(Ad)-CTRP9 and Ad-green fluorescent protein viral particles were injected into the rats through the tail ...

Clinical Outcomes of COVID-19 and Impact on Disease Course in Patients with Inflammator...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632463
Canadian Journal of Gastroenterology & Hepatology; Wetwittayakhlang P, Albader F et. al.

Dec 4th, 2021 - The impact of COVID-19 has been of great concern in patients with inflammatory bowel disease (IBD) worldwide, including an increased risk of severe outcomes and/or possible flare of IBD. This study aims to evaluate prevalence, outcomes, the impact of COVID-19 in patients with IBD, and risk factors associated with severe COVID-19 or flare of IBD activity. A consecutive cohort of IBD patients who...

Social Media as a Tool to Educate Plastic Surgeons on Patients' Concerns Before and Aft...
https://doi.org/10.1007/s00266-021-02676-8 10.1007/s00266-012-9977-z 10.1016/j.pec.2017.08.015 10.1136/bmjqs-2012-001527 10.1097/PRS.0b013e318287a072 10.1097/00006534-200209010-00039 10.1097/PRS.0b013e31818d20ec 10.1177/1357034X10383881 10.1111/j.1467-954X.2012.02127.x 10.1054/bjps.1999.3110 10.1097/00006534-199708000-00032 10.1177/1090820X11410868 10.1097/PRS.0000000000003785 10.1097/PRS.0000000000007784 10.1007/s00266-020-01724-z 10.1093/asj/sjaa115
Aesthetic Plastic Surgery; Shaul N, Hadad E et. al.

Dec 4th, 2021 - The rapid evolution of the social media platform has had a major effect on the field of medicine. To identify patterns, trends and patients' concerns before and after aesthetic surgeries involving breast implants, by analyzing social media posts. We examined comments posted on popular Israeli online public forums between January 2019 and May 2021, regarding: breast augmentation, mastopexy-augme...

Immunogenicity and safety of mRNA COVID-19 vaccines in people with multiple sclerosis t...
https://doi.org/10.1007/s13311-021-01165-9 10.1016/j.ijbiomac.2020.06.213 10.1016/j.msard.2021.102788 10.1016/j.msard.2021.102880 10.1016/j.msard.2020.102439 10.1016/j.jneuroim.2021.577599 10.1177/13524585211003476 10.1038/s41586-020-2852-1 10.1038/s41591-021-01377-8 10.1177/17562864211012835 10.1016/j.neurol.2021.05.001 10.1016/j.msard.2021.102983 10.1016/s1474-4422(17)30470-2 10.15585/mmwr.mm6950e2 10.1111/ene.15028 10.1177/17562864211038111 10.1016/j.msard.2021.103150 10.1212/wnl.0000000000010380 10.1016/j.ijid.2021.06.054 10.1056/NEJMc2108861 10.1002/jcla.23921
Neurotherapeutics : the Journal of the American Society F... Capone F, Lucchini M et. al.

Dec 4th, 2021 - The potential impact of disease-modifying therapies (DMTs) for multiple sclerosis (MS) on COVID-19 vaccination is poorly understood. According to recent observations, the humoral immune response could be impaired in patients treated with ocrelizumab or fingolimod. Our study evaluated the immunogenicity and safety of mRNA COVID-19 vaccines in a convenience sample of 140 MS patients treated with ...

Comparison of the efficacy and safety of 308-nm excimer laser with intralesional cortic...
https://doi.org/10.1002/lsm.23501
Lasers in Surgery and Medicine; Kianfar N, Dasdar S et. al.

Dec 4th, 2021 - Corticosteroids have been the mainstay of treatment for alopecia areata (AA). Recently, the 308-nm excimer laser has been proposed for treating AA. To compare the efficacy and safety of excimer laser with intralesional corticosteroid (ILCS) in AA. Patients with at least two alopecic patches were randomly assigned to receive weekly excimer laser treatments or monthly injections of ILCS. Photogra...

Revisiting oral thrush in Southeast Asian patients: A review of published studies (2000...
https://doi.org/10.1111/jop.13266
Journal of Oral Pathology & Medicine : Official Publicati... Karajacob AS, Mohammed Al Maleki AR et. al.

Dec 4th, 2021 - Oral thrush, a clinical condition due to an overgrowth of Candida yeasts in the oral cavity, is prominent in patients with immunosuppression. As recent updates on oral thrush in Southeast Asia (SEA) countries are lacking, this review aims to address the epidemiology, clinical features, and distribution of Candida species, based on published studies in SEA over the last two decades. Published st...

Health-related quality of life, obesity, fragmented sleep, fatigue, and psychosocial pr...
https://doi.org/10.1002/pon.5862
Psycho-oncology Klages KL, Berlin KS et. al.

Dec 4th, 2021 - Youth with craniopharyngioma experience weight gain, fragmented sleep, excessive daytime sleepiness (EDS), fatigue, and psychosocial problems that negatively impact their overall health-related quality of life (HRQoL). Greater hypothalamic tumor involvement (HI) may be associated with higher rates or severity of these impairments; however, the direct and indirect impact of HI on the physical an...

Non-coding RNAs underlying the pathophysiological links between Type 2 diabetes and pan...
https://doi.org/10.1111/jdi.13727
Journal of Diabetes Investigation; Dehghanian F, Azhir Z et. al.

Dec 4th, 2021 - Type 2 diabetes (T2D) is known as a risk factor for pancreatic cancer (PC). Various genetic and environmental factors cause both these global chronic diseases. So, the mechanisms which define their relationships are complex and poorly understood. Recent studies implicated that metabolic abnormalities, including hyperglycemia and hyperinsulinemia, could lead to cell damage responses, cell transf...

Abdominal aortic aneurysm neck dilatation and sac remodeling in fenestrated compared to...
https://doi.org/10.1177/17085381211052802
Vascular Li C, Teter K et. al.

Dec 4th, 2021 - Contemporary commercially available endovascular devices for the treatment of abdominal aortic aneurysm (AAA) include standard endovascular aortic repair (sEVAR) or fenestrated EVAR (fEVAR) endografts. However, aortic neck dilatation (AND) can occur in nearly 25% of patients following EVAR, resulting in loss of proximal seal with risk of aortic rupture. AND has not been well characterized in fE...

Assessment of automatic decision-support systems for detecting active T2 lesions in mul...
https://doi.org/10.1177/13524585211061339
Multiple Sclerosis (Houndmills, Basingstoke, England); Rovira A, Corral JF et. al.

Dec 4th, 2021 - Active (new/enlarging) T2 lesion counts are routinely used in the clinical management of multiple sclerosis. Thus, automated tools able to accurately identify active T2 lesions would be of high interest to neuroradiologists for assisting in their clinical activity. To compare the accuracy in detecting active T2 lesions and of radiologically active patients based on different visual and automate...

Phenotypic spectrum and long-term outcome of children with genetic early-infantile-onse...
https://doi.org/10.1684/epd.2021.1394
Epileptic Disorders : International Epilepsy Journal With... Hu C, Liu D et. al.

Dec 4th, 2021 - Developmental and epileptic encephalopathy (DEE) is characterized by refractory seizures, developmental delay or intellectual disability, which may be caused by gene mutation. In this study, we explored the clinical phenotype and long-term outcome in children with genetic early-infantile-onset DEEs. Next-generation sequencing was performed on 470 patients diagnosed with early-infantile-onset DE...

Probable Transmission of SARS-CoV-2 Omicron Variant in Quarantine Hotel, Hong Kong, Chi...
https://doi.org/10.3201/eid2802.212422
Emerging Infectious Diseases; Gu H, Krishnan P et. al.

Dec 4th, 2021 - We report detection of severe acute respiratory syndrome coronavirus 2 Omicron variant (B.1.1.529) in an asymptomatic, fully vaccinated traveler in a quarantine hotel in Hong Kong, China. The Omicron variant was also detected in a fully vaccinated traveler staying in a room across the corridor from the index patient, suggesting transmission despite strict quarantine precautions.

Association of Metabolic Syndrome with Glaucoma and Ocular Hypertension in a Midwest Un...
https://doi.org/10.1097/IJG.0000000000001968
Journal of Glaucoma; Wu KY, Hodge DO et. al.

Dec 4th, 2021 - For patients with glaucomatous optic neuropathy, metabolic syndrome was associated with higher intraocular pressure and higher central corneal thickness. Patients with metabolic syndrome were also more likely to have ocular hypertension. To determine whether glaucomatous optic neuropathy, also known as glaucoma, and ocular hypertension are more likely to occur in patients with metabolic syndrom...

Differences in upper esophageal sphincter function and clinical characteristics among t...
https://doi.org/10.1007/s10388-021-00897-z 10.1001/jama.2015.2996 10.1111/nmo.12477 10.4103/1319-3767.157560 10.15403/jgld-768 10.5056/jnm.2013.19.4.485 10.1111/nmo.12711 10.1002/bjs.11049 10.1016/j.dld.2017.11.012 10.1111/nmo.13136 10.1016/j.dld.2012.07.019 10.1111/j.1751-2980.2012.00622.x 10.1159/000343902 10.1016/j.cgh.2018.01.031 10.1038/gimo37 10.1053/j.gastro.2015.07.007 10.1007/s00268-020-05396-3 10.3390/geriatrics3040067 10.1016/S0140-6736(07)61602-X 10.1002/lio2.324 10.1152/ajpgi.00019.2017 10.3109/00365521003592663 10.1007/s00455-016-9712-z 10.1016/0002-9610(92)90041-O 10.1111/j.1572-0241.2003.07266.x 10.1038/ajg.2014.13 10.1136/gutjnl-2020-320772
Esophagus : Official Journal of the Japan Esophageal Soci... Katsumata R, Manabe N et. al.

Dec 4th, 2021 - The rarity of esophageal achalasia has resulted in little being known about the characteristics of its three subtypes. The upper esophageal sphincter is considered one key factor to prevent aspiration pneumonia, a serious complication of esophageal achalasia. This study aimed to reveal the subtype characteristics of esophageal achalasia and how the upper esophageal sphincter functions and relat...

Correlation of plasma and urine Wnt5A with the disease activity and cutaneous lesion se...
https://doi.org/10.1007/s12026-021-09253-w 10.1101/cshperspect.a008029
Immunologic Research; Chi S, Xue J et. al.

Dec 4th, 2021 - Reliable noninvasive biomarkers are needed to accurately assess disease activity and prognosis in patients with systemic lupus erythematosus (SLE). The purpose of this study was to investigate the clinical relevance of Wnt5A with disease activity and severity with cutaneous involvement in particular in SLE patients; its concentrations in plasma and urine were examined and analyzed. In the cross...

Features of inflammatory heart reactions following mRNA COVID-19 vaccination at a globa...
https://doi.org/10.1002/cpt.2499
Clinical Pharmacology and Therapeutics; Chouchana L, Blet A et. al.

Dec 4th, 2021 - Myocarditis and pericarditis may constitute adverse reactions of mRNA COVID-19 vaccines. This study aimed to document these reactions and to assess the association with patient sex and age. This is as an observational retrospective study using a case-non-case design (also called disproportionality study) on inflammatory heart reactions reported with mRNA COVID-19 vaccines within the WHO global ...