Jan 20th, 2022 - WAIKOLOA, Hawaii — Ophthalmologists should consider co-management of other diseases when treating progressive glaucoma, according to a speaker here. “I think that we need to remind ourselves, even as we rush through clinic, to think about the linkage to common disease that puts the optic nerve at risk,” Jeffrey L. Goldberg, MD, PhD, said at Hawaiian Eye 2022. To aid with co-management, he said,...

Jan 18th, 2022 - WAIKOLOA, Hawaii — Just past the 15-year anniversary of the cefuroxime ESCRS trial, debate regarding antibiotic prophylaxis for endophthalmitis after cataract surgery continues. “When you have something controversial, it's nice to see what our colleagues are doing,” David F. Chang, MD, said at Hawaiian Eye 2022. To that end, surveys of ASCRS members conducted in 2007, 2014 and 2021 published in...

Jan 16th, 2022 - WAIKOLOA, Hawaii — It is important for physicians to consider “the perils that dwell” in the diagnostic management of patients with uveitis, Steven Yeh, MD, said during a presentation at Hawaiian Eye 2022. “With these patients being very complex oftentimes, we really just don’t want to miss something,” Yeh said. To better identify “the pearls amongst the perils” in uveitis diagnosis, it is impo...

Mar 27th, 2023 - The purpose of this protocol is to study the natural history of spondyloarthritis (SpA) in children and adults. Spondyloarthritis encompasses a spectrum of immune-mediated inflammatory diseases that exhibit overlapping features, but differ from other types of inflammatory arthritis in genetic predisposition, pathogenesis, and outcome. Ankylosing spondylitis (AS), the most common form of SpA, fr...

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

Aug 23rd, 2019 - To update evidence-based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA). We conducted updated systematic literature reviews for 20 clinical questions on pharmacologic treatment addressed in the 2015 guidelines, and for 26 new questions on pharmacologic treatment, treat-to-target strategy, and use of imaging. New q...

Apr 1st, 2023 - Spironolactone tablets are an aldosterone antagonist indicated for: •The treatment of NYHA Class III-IV heart failure and reduced ejection fraction to increase survival, manage edema, and to reduce the need for hospitalization for heart failure (1.1). •Use as an add-on therapy for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfa...

Mar 31st, 2023 - Complex polypharmacy in patients with bipolar disorder was associated with sociodemographic and clinical features, including older age, single status, and psychiatric comorbidities, based on data from more than 500 individuals. Patients with bipolar disorder (BD) often receive prescriptions for multiple medications to manage a range of medical and psychiatric symptoms, but the definition of pol.

Mar 31st, 2023 - Diagnosing and treating infectious conjunctivitis is relatively routine, but the costs to the family and society can be significant. Currently, no uniform conjunctivitis treatment protocols for managing acute infectious conjunctivitis in children exist, and according to the American Academy of Pediatrics, the role of antibiotics is unclear.1-3 Acute conjunctivitis — an eye condition most common...

Mar 31st, 2023 - Anti-amyloid therapies for Alzheimer's disease accelerated brain atrophy, a systematic review and meta-analysis of MRI data showed. Across 31 clinical trials, brain volume changes were seen for different classes of anti-amyloid agents, reported Scott Ayton, PhD, of the University of Melbourne in Australia, and co-authors in Neurology. The analysis focused mainly on two types of anti-amyloid dru...

Mar 31st, 2023 - To the Editor: Subcutaneous panniculitic T-cell lymphoma (SPTCL) is a rare cutaneous T-cell lymphoma that was first described in 19911 and comprises less than 1% of all non-Hodgkin lymphomas (NHLs). It most commonly occurs in young adults, with a median patient age of 36 years and a slight female predominance.

Mar 31st, 2023 - Note that some links may require subscriptions. Higher levels of physical activity may diminish the mortality risk associated with poor sleep, according to findings from the U.K. Biobank. (European Journal of Preventive Cardiology) Despite saying he strongly opposes it, President Biden has no plans to veto a Republican-led measure to end the national COVID-19 emergency; however, the public heal...

Mar 31st, 2023 - Genotyping results from blood samples of U.S. children with severe acute hepatitis of unknown cause support prior research suggesting that adeno-associated virus 2 (AAV2) along with a "helper" virus may be to blame for last year's global outbreak. In 13 of 14 mystery hepatitis cases (93%), blood samples turned up positive for AAV2 -- a virus not previously recognized as pathogenic, and which re...

Mar 31st, 2023 - History The biochemical collagen defect is present at birth, but clinical manifestations become evident later. Shoulder dislocation is often the initial sign of Ehlers-Danlos syndrome (EDS). Regrettably, the value of clinical tests for generalized joint hypermobility, Ehlers-Danlos syndrome, hypermobility type, and joint hypermobility syndrome may be less than ideal. [26] The skin findings prov...

Mar 31st, 2023 - Laboratory Studies Laboratory studies during an eczematous drug eruption may disclose eosinophilia, leukocytosis, and elevated sedimentation rate. In AGEP, laboratory studies demonstrate neutrophilia in 90% of cases and eosinophilia in 30% of cases. Liver function is usually normal. Laboratory studies in FDE may show leukocytosis, hypereosinophilia, and hypergammaglobulinemia. However, clinical...

Mar 31st, 2023 - Background Paralysis of the upper extremity produces major functional impairment. The ability to perform activities of daily life can be severely compromised, especially in bilateral paralysis. When muscle-tendon units remain functional in an extremity, consider sacrificing one function to restore another by transferring the working unit to a new location. Restoring something as simple as a pin...

Mar 31st, 2023 - Background Paralysis of the upper extremity produces major functional impairment. The ability to perform activities of daily life can be severely compromised, especially in bilateral paralysis. When muscle-tendon units remain functional in an extremity, consider sacrificing one function to restore another by transferring the working unit to a new location. Restoring something as simple as a pin...

Mar 31st, 2023 - Practice Essentials Ehlers-Danlos syndromes (EDS), the name given to a group of more than 10 different inherited, clinically and genetically heterogeneous group of connective-tissue disorders, involves a genetic defect in collagen and connective-tissue synthesis and structure. In 2017, a new international classification was proposed with 13 different variants. [1, 2] Signs and symptoms Also see...

Mar 31st, 2023 - Practice Essentials Ehlers-Danlos syndromes (EDS), the name given to a group of more than 10 different inherited, clinically and genetically heterogeneous group of connective-tissue disorders, involves a genetic defect in collagen and connective-tissue synthesis and structure. In 2017, a new international classification was proposed with 13 different variants.[1, 2] Signs and symptoms Also see ...

Mar 31st, 2023 - Practice Essentials Malignant melanoma (see the image below) is a neoplasm of melanocytes or a neoplasm of the cells that develop from melanocytes. Although it was once considered uncommon, the annual incidence has increased dramatically over the past few decades. Surgery is the definitive treatment for early-stage melanoma, with medical management generally reserved for adjuvant treatment of h...