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About 21,608 results

Artificial intelligence assisted cytological detection for early esophageal squamous ep...
https://doi.org/10.1002/cam4.4984
Cancer Medicine; Yao B, Feng Y et. al.

Jun 30th, 2022 - Manual cytological diagnosis for early esophageal squamous cell carcinoma (early ESCC) and high-grade intraepithelial neoplasia (HGIN) is unsatisfactory. Herein, we have introduced an artificial intelligence (AI)-assisted cytological diagnosis for such lesions. Low-grade squamous intraepithelial lesion or worse was set as the diagnostic threshold for AI-assisted diagnosis. The performance of AI...

Less Than Subtotal Parathyroidectomy for Multiple Endocrine Neoplasia Type 1 Primary Hy...
https://doi.org/10.1007/s00268-022-06633-7 10.1111/j.1365-2265.2008.03324.x 10.1038/s41574-021-00468-3 10.1067/msy.1998.93107 10.1097/SLA.0b013e31815efda5 10.1111/j.1365-2265.2009.03672.x 10.1007/s12020-017-1377-3 10.1210/jc.2016-1477 10.1210/jc.2015-3909 10.1016/S0002-9440(10)64406-9 10.3389/fendo.2019.00123 10.1007/s00268-011-1068-9 10.1016/j.ijsu.2010.02.007 10.1001/jama.283.15.2008 10.1097/SLA.0b013e31824c5145 10.1007/s00268-016-3624-9 10.1038/s41598-020-67424-5 10.1186/1750-1172-8-50 10.1111/j.1365-2265.2006.02438.x 10.1007/s00268-017-4366-z 10.1067/msy.2002.128607 10.1530/EC-19-0321 10.1007/s00104-004-0838-4 10.1007/BF01655552 10.1111/cen.14112 10.1001/archsurg.141.3.235 10.1002/bjs.7154 10.1001/archsurg.140.4.374 10.1007/s00268-015-3297-9 10.1080/110241501750099294 10.1016/j.surg.2013.03.004 10.1016/j.ciresp.2018.06.014 10.1245/ASO.2006.12.009 10.1016/s0039-6060(03)00406-9 10.1016/j.surg.2014.08.006 10.1001/jamasurg.2016.2310 10.1530/EJE-18-0580 10.1210/jc.2012-1808 10.1002/jbmr.1979 10.4158/EP13328.OR 10.1002/jbmr.2273 10.1016/j.jamcollsurg.2014.07.412 10.1007/s00268-012-1451-1 10.1007/s00259-018-4123-z 10.1007/s00268-020-05695-9 10.2967/jnumed.119.225771 10.1002/lary.28566 10.1007/s10897-006-9047-2 10.1016/j.surg.2020.08.021 10.3389/fendo.2018.00558 10.1016/S0039-6060(98)70040-6
World Journal of Surgery; Bouriez D, Gronnier C et. al.

Jun 30th, 2022 - Multiple endocrine neoplasia type 1 (MEN1)-associated primary hyperparathyroidism (pHPT) is classically associated with an asymmetric and asynchronous parathyroid involvement. Subtotal parathyroidectomy (STP), which is currently the recommended surgical treatment, carries a high risk of permanent hypoparathyroidism. The results of less than subtotal parathyroidectomy (LSTP) are conflicting, and...

Cancer Risk and Autism Spectrum Disorder: Is There a Link?
https://www.medscape.com/viewarticle/976345

Jun 29th, 2022 - Individuals with autism spectrum disorder (ASD) may be at higher risk of developing cancer early in life, but this risk seems largely related to the presence of co-occurring birth defects or intellectual disability, according to new findings. Researchers found that people with ASD and birth defects had a twofold higher risk of cancer compared with those without ASD. For individuals with birth d...

Risk-Based Cervical Consensus Guidelines: Methods to Determine Management if Less Than ...
https://doi.org/10.1097/LGT.0000000000000685
Journal of Lower Genital Tract Disease; Egemen D, Perkins RB et. al.

Jun 29th, 2022 - In the 2019 ASCCP Risk-Based Management Consensus Guidelines, clinical management decisions are based on immediate and 5-year cervical intraepithelial neoplasia (CIN) 3+ risk estimates. However, data for technologies other than human papillomavirus testing and cytology may be limited to clinical trials and observational studies of shorter duration than 5 years. To enable decisions about 1- or 3...

Beyond Wilms tumor: imaging findings and outcomes of rare renal tumors in children.
https://doi.org/10.1007/s00247-022-05422-7 10.1016/S0959-8049(01)00043-0 10.1148/radiographics.20.6.g00nv051585 10.1148/rg.2016150230 10.1016/S0094-0143(05)70094-X 10.1016/j.jss.2010.03.061 10.1016/j.jpedsurg.2008.02.077 10.1148/rg.2017160189 10.1016/j.clinimag.2015.05.002 10.1542/pir.2017-0057 10.1016/S1470-2045(07)70241-3 10.1002/cncr.29368 10.1016/j.path.2010.06.011 10.1002/jmri.22392 10.1007/s00330-016-4421-4 10.1016/j.ejca.2013.06.036 10.1002/cncr.21836 10.1007/s00247-009-1354-y 10.1007/s00247-009-1348-9 10.1016/j.clinimag.2005.09.027 10.2214/ajr.168.2.9016225 10.1007/s00247-012-2485-0 10.1148/rg.2016150245 10.2214/AJR.15.14548 10.1097/PAS.0000000000000816 10.1002/jmri.27878 10.1016/S2352-4642(19)30340-2 10.1002/jmri.25901
Pediatric Radiology; Ayaz E, Ozcan HN et. al.

Jun 28th, 2022 - Compared to Wilms, non-Wilms renal tumors in children are less well understood due to their rare occurrence which limits precise definition of the typical imaging patterns. This study aims to identify distinctive imaging findings, demographic characteristics and prognosis of pediatric non-Wilms renal tumors. From January 2007 to December 2018, 207 patients with a diagnosis of primary kidney neo...

Cancer May Increase Risk of Type 2 Diabetes
https://www.medscape.com/viewarticle/976224

Jun 27th, 2022 - A large Danish study has found that cancer increases the risk of new-onset type 2 diabetes, especially certain types of cancer, most notably pancreatic malignancies. "Our study demonstrates that there is an elevated risk of developing diabetes if a person is affected by lung, pancreatic, breast, brain, urinary tract, or uterine cancers," said Lykke Sylow, PhD, associate professor in the Molecul...

Comparison Between Sporadic and Multiple Endocrine Neoplasia Type 1-Associated Insulinoma.
https://doi.org/10.1097/XCS.0000000000000307
Journal of the American College of Surgeons; Sada A, Habermann EB et. al.

Jun 26th, 2022 - The differences between sporadic and MEN-1 associated insulinoma are not well described. Herein, we compared demographics, neoplasm characteristics, presentation, and survival in patients with sporadic vs MEN-1 insulinomas including benign and malignant disease. A retrospective study identified insulinoma patients. MEN-1 was defined based on genetic testing or clinically in patients with two or...

Clinical impact and prognosis of cryoglobulinemia and cryofibrinogenemia in systemic sc...
https://doi.org/10.1016/j.autrev.2022.103133
Autoimmunity Reviews; Chaves SA, Puissant B et. al.

Jun 26th, 2022 - An association of systemic sclerosis (SSc) with cryoglobulin and/or cryofibrinogenemia has been described. However, clinical, biological, morphological and prognostic implications are unknown. The objective of this study was to describe the phenotype and evaluate the prognosis of cryoglobulinemia and/or cryofibrinogenemia in the progression of SSc. Patients were included from the Systemic Scler...

Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more ...
https://doi.org/10.1186/s12967-022-03490-9 10.21037/tlcr.2019.11.23 10.21037/tlcr.2020.01.16 10.1200/JCO.2003.11.136 10.1016/S0140-6736(15)01238-6 10.1245/ASO.2006.05.041 10.1016/j.tips.2011.03.011 10.1038/ng.3520 10.1158/0008-5472.CAN-14-1008 10.1097/JTO.0000000000000436 10.2174/1389450116666150804110714 10.2174/092986708783955446 10.3389/fonc.2020.00343 10.1016/j.lungcan.2005.10.016 10.1080/17425247.2019.1598374 10.1016/j.canlet.2017.02.015 10.1016/j.jtho.2017.04.028 10.1200/JCO.2006.09.7634 10.1158/1078-0432.CCR-04-1940 10.1097/PDM.0b013e3182a3645e 10.1097/JTO.0b013e31819c8661 10.18632/oncotarget.2941 10.1016/j.devcel.2008.11.010 10.18632/oncotarget.7062 10.1101/gad.1693608 10.3390/ijms22031042 10.1158/1078-0432.CCR-12-0599 10.2741/4180 10.1186/1756-9966-32-1 10.1016/S0002-9440(10)61743-9 10.1177/019262339702500605 10.1007/s00280-007-0608-3 10.1038/nprot.2006.179 10.1080/2162402X.2017.1356151 10.1080/09637486.2016.1236077 10.1007/s13277-015-4207-3 10.1007/s00280-004-0838-6 10.18632/oncotarget.2534 10.1002/0471142735.ima03bs111 10.3389/fphar.2018.01269 10.1186/s12967-015-0455-7 10.3389/fphar.2017.00373 10.2741/3940 10.18632/oncotarget.14907 10.1038/s41598-021-98450-6 10.1038/s41389-019-0175-6 10.4061/2010/920161 10.1016/j.molcel.2006.05.023 10.1038/bjc.2011.133 10.3389/fgene.2019.01121 10.1016/j.ctrv.2022.102354 10.2217/fon-2020-1255 10.3390/cancers13040688 10.3892/ijo.2021.5168 10.1016/j.ejca.2021.06.026 10.1371/journal.pone.0057346 10.3389/fgene.2019.00556 10.1073/pnas.0609699104 10.1002/jcb.26572 10.1016/j.jtcvs.2013.08.035 10.18632/oncotarget.4224 10.3892/or.2015.4314 10.18632/oncotarget.2729 10.1177/1947601913507951 10.1038/sj.onc.1207556 10.7314/APJCP.2014.15.20.8539 10.1002/med.21574 10.1016/j.canlet.2013.11.019 10.1073/pnas.0700776104 10.1073/pnas.0504337103 10.1158/0008-5472.CAN-05-2539 10.1158/0008-5472.CAN-08-2331 10.18632/oncotarget.15479 10.1016/j.jtho.2016.01.014 10.1097/JTO.0b013e31828c2b26 10.1097/JTO.0b013e3181ec18db 10.1016/j.cllc.2013.12.008 10.1200/JCO.19.00269 10.1158/0008-5472.CAN-19-1633 10.3390/ijms20225817
Journal of Translational Medicine; Bei R, Benvenuto M et. al.

Jun 26th, 2022 - Malignant mesothelioma (MM) is a rare orphan aggressive neoplasia with low survival rates. Among the other signaling pathways, ErbB receptors and Hh signaling are deregulated in MM. Thus, molecules involved in these signaling pathways could be used for targeted therapy approaches. The aim of this study was to evaluate the effects of inhibitors of Hh- (GANT-61) and ErbB receptors (Afatinib)-medi...

Malignancy Diseases in Kidney Transplantation, Clinical Outcomes, Patient, and Allograf...
https://doi.org/10.1016/j.transproceed.2022.02.063
Transplantation Proceedings; Pinto-Filho VA, Nascimento E et. al.

Jun 25th, 2022 - Malignancy is a well-known complication in patients after kidney transplantation (KT), but its effect on posttransplant outcomes, allograft, and patient survival remains unexplored. The aim of this study is to report the impact of the comorbidity on clinical outcome, function, and failure of an allograft kidney. This case-control study included 101 KT patients. Twenty-six patients who developed...

Growth Hormone
https://emedicine.medscape.com/article/2089136-overview

Jun 24th, 2022 - Reference Range Random growth hormone (GH) levels in a healthy person range as follows [1] : Men - < 5 ng/mL (mcg/L [SI units]) Women - < 10 ng/mL (mcg/L [SI units]) Newborns - 5-23 ng/mL (mcg/L [SI units]) 1 week - 2-27 ng/mL (mcg/L [SI units]) 1-12 mos - 2-10 ng/mL (mcg/L [SI units]) 1 year (female) - 0-10 g/mL (mcg/L [SI units]) 1 year (male) - 0-6 ng/mL (mcg/L [SI units]) GH suppression tes...

Growth Hormone
http://emedicine.medscape.com/article/2089136-overview

Jun 24th, 2022 - Reference Range Random growth hormone (GH) levels in a healthy person range as follows [1] : Men - < 5 ng/mL (mcg/L [SI units]) Women - < 10 ng/mL (mcg/L [SI units]) Newborns - 5-23 ng/mL (mcg/L [SI units]) 1 week - 2-27 ng/mL (mcg/L [SI units]) 1-12 mos - 2-10 ng/mL (mcg/L [SI units]) 1 year (female) - 0-10 g/mL (mcg/L [SI units]) 1 year (male) - 0-6 ng/mL (mcg/L [SI units]) GH suppression tes...

Growth Hormone
https://emedicine.medscape.com/article/2089136-print

Jun 24th, 2022 - Random growth hormone (GH) levels in a healthy person range as follows[1] : Men - < 5 ng/mL (mcg/L [SI units]) Women - < 10 ng/mL (mcg/L [SI units]) Newborns - 5-23 ng/mL (mcg/L [SI units]) 1 week - 2-27 ng/mL (mcg/L [SI units]) 1-12 mos - 2-10 ng/mL (mcg/L [SI units]) 1 year (female) - 0-10 g/mL (mcg/L [SI units]) 1 year (male) - 0-6 ng/mL (mcg/L [SI units]) GH suppression test value (using 10...

Natural History Study of Children and Adults With Medullary Thyroid Cancer
https://clinicaltrials.gov/ct2/show/NCT01660984

Jun 24th, 2022 - Background: Medullary Thyroid Carcinoma (MTC) is a calcitonin producing tumor arising from the parafollicular C cells of thyroid. In children and adults, MTC is usually seen in association with Multiple Endocrine Neoplasia (MEN) 2A and 2B, which are rare cancer syndromes resulting from germline mutations of Rearranged during Transfection (RET) proto-oncogene. MTC develops in virtually all patie...

Natural History Study of Children and Adults With Neuroendocrine Neoplasms (NEN)s
https://clinicaltrials.gov/ct2/show/NCT04488263

Jun 24th, 2022 - Background: Neuroendocrine neoplasm (NENs) are divided into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs). These are rare malignancies occurring for example in the gastrointestinal tract, islets of the pancreas, lung, adrenal medulla, thyroid C-cells, etc. and are heterogeneous group of neoplasms with unique tumor biology, natural history, and clinical management issues. The...

Natural History Study of Parathyroid Disorders
https://clinicaltrials.gov/ct2/show/NCT04969926

Jun 24th, 2022 - Study Description: Patients with confirmed, suspected or at risk of developing parathyroid disorders will be provided standard of care testing for their condition. Data obtained during the testing will be used for research. Additionally, samples may be collected for research. Objectives: To investigate the cause of the disease and its associated manifestations, possibly genetic in participants ...

Tissue Procurement and Natural History Study of Neuroendocrine Neoplasms (NENs) Including Adrenocortical Carcinoma (ACC)
https://clinicaltrials.gov/ct2/show/NCT05237934

Jun 24th, 2022 - Background: Neuroendocrine neoplasms (NENs) are divided into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs). These are rare malignancies occurring for example in the gastrointestinal tract, islets of the pancreas, lung, adrenal medulla, thyroid C-cells, etc., and is a heterogeneous group of neoplasms with unique tumor biology, natural history, and clinical management issues. ...

Cause of Familial Testicular Cancer
https://clinicaltrials.gov/ct2/show/NCT00034424

Jun 24th, 2022 - BACKGROUND: Testicular germ cell tumor (TGCT) is the most common cancer in men aged 20-35, with an increasing incidence since the mid-twentieth century. A family history of TGCT is associated with an increased risk of the disease. Evidence suggests that there is genetic heterogeneity in familial TGCT, thereby creating opportunities for both new susceptibility gene discovery and searching for ge...

Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Cancer
https://clinicaltrials.gov/ct2/show/NCT00001163

Jun 24th, 2022 - Background: Persons may be prone to develop cancer for a variety of reasons including: inherited predisposition benign, premalignant, or malignant conditions; environmental exposures shared by family members; previous tumors, immune deficiency, or preneoplastic conditions. Investigations of individuals and families at high risk of cancer often lead to etiologic clues that may be important in th...

Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
https://clinicaltrials.gov/ct2/show/NCT00001452

Jun 24th, 2022 - Primary pigmented nodular adrenocortical disease (PPNAD) is a pituitary-independent, primary adrenal form of hypercortisolism characterized by (a) resistance to suppression by dexamethasone and abolition of the normal diurnal rhythm of cortisol secretion, and (b) distinctive, bilateral, histopathologic changes of the adrenal glands, such as the formation of variably sized, pigmented nodular ade...