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About 19,210 results

Follicular lymphoma treated with first-line immunochemotherapy: a review of PET-CT in p...
https://doi.org/10.2967/jnumed.121.262869
Journal of Nuclear Medicine : Official Publication, Socie... Barrington SF, Mir F et. al.

Dec 4th, 2021 - Complete metabolic response (CMR) on positron emission tomography-computed tomography (PET-CT) was the sole independent predictor of overall survival in the PET sub-study of the phase III GALLIUM trial (NCT01332968) in first-line treatment of high tumour burden follicular lymphoma (FL). The aim of this analysis was to investigate further the outcome of patients not achieving CMR. Methods: Two i...

Clinical, Biochemical, Tumoural and Mutation Profile of VHL- and MEN2A-Associated Pheoc...
https://doi.org/10.1007/s00268-021-06393-w 10.1016/j.critrevonc.2016.01.022 10.1055/s-0031-1301302 10.1210/jc.2018-02411 10.1210/jcem.86.5.7496 10.7326/0003-4819-120-6-199403150-00006 10.1046/j.1365-2265.1998.3751208.x 10.1210/jc.2015-3045 10.1056/NEJM199906173402404 10.1385/EP:13:1:17 10.1007/s10689-017-0058-y
World Journal of Surgery; Dhanda M, Agarwal A et. al.

Dec 4th, 2021 - To compare clinical, biochemical, tumoural and mutational characteristics of Von Hippel Lindau Syndrome (VHL)-associated pheochromocytoma (PCC) to multiple endocrine neoplasia 2A (MEN2A)-associated pheochromocytoma. Retrospective study design in a tertiary health care centre in Northern India. A total of 47 patients with biochemical and histologically proven pheochromocytoma/paraganglioma (PCC/...

Self-sampling as the principal modality for population based cervical screening: five-y...
https://doi.org/10.1002/ijc.33888
International Journal of Cancer; Stanczuk GA, Currie H et. al.

Dec 2nd, 2021 - Self-sampling provides a powerful means to engage women in cervical screening. In the original Papillomavirus Dumfries and Galloway study (PaVDaG) 1 we demonstrated cross-sectional similarity of Hr-HPV testing on self-taken vaginal vs. clinician-taken samples for the detection of cervical intraepithelial neoplasia 2 or worse (CIN2+). Few data exist on the longitudinal performance of self-sampli...

Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney comp...
https://doi.org/10.1172/JCI146910
The Journal of Clinical Investigation; Djari C, Sahut-Barnola I et. al.

Dec 2nd, 2021 - Large-cell calcifying Sertoli cell tumors (LCCSCTs) are among the most frequent lesions occurring in male Carney complex (CNC) patients. Although they constitute a key diagnostic criterion for this rare multiple neoplasia syndrome resulting from inactivating mutations of the tumor suppressor PRKAR1A, leading to unrepressed PKA activity, LCCSCT pathogenesis and origin remain elusive. Mouse model...

The Vaginal Microecology and Innate Immunity After Focused Ultrasound Ablation Treatment for CIN
https://clinicaltrials.gov/ct2/show/NCT05142397

Dec 2nd, 2021 - Studies have shown that the mucus secreted by cervical mucosa is the main physical barrier against HPV. HPV can invade through locally damaged cervical mucosa that stimulate the body's non-specific immunity and specific immune response to resist the invasion of the virus.The specific cellular immune response plays a major role in resisting virus proliferation and inhibiting tumor progression. W...

Surgical outcomes of diaphragmatic resection during cytoreductive surgery for advanced ...
https://doi.org/10.1016/j.ygyno.2021.11.012
Gynecologic Oncology; Cianci S, Fedele C et. al.

Dec 1st, 2021 - Ovarian cancer (OC) represent nearly 4% of gynecologic malignancies and it is often diagnosed at advanced stage. Diaphragmatic surgery, a fundamental step of advanced stage ovarian cancer (ASOC) debulking surgery, is associated with a high post-operative complication incidence, which is supposedly reduced with thoracostomy tube placement. We assessed the role of intra-operative thoracostomy tub...

Bilateral idiopathic temporal bone meningoencephaloceles - An unusual presentation.
https://doi.org/10.4103/jpgm.jpgm_566_21
Journal of Postgraduate Medicine; Muranjan SN, Singhal DD et. al.

Dec 1st, 2021 - Meningoencephaloceles (MECs) occur due to herniation of brain tissue through a bony defect in the skull base. They can be spontaneous or acquired. These are secondary to trauma, infection or neoplasia. Adult-onset spontaneous or idiopathic MECs are rare. Temporal bone MECs can present with watery discharge from the ear, conductive hearing loss or symptoms of meningitis like headache, fever, vom...

Severe hypercalcemia requiring acute hemodialysis: A retrospective cohort study with in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585552
The American Journal of Emergency Medicine; Bentata Y, Benabdelhak M et. al.

Nov 26th, 2021 - The Covid-19 pandemic has had dramatic consequences on the progression of numerous pathologies, especially neoplastic ones. The orientation of hospital activities toward the care of patients with SARS-Cov2 infection has caused significant delays in the diagnosis and therapy of many other pathologies. What about severe hypercalcemia? The aim of this work was to determine the clinical and biologi...

Risperidone - risperidone tablet-Ajanta Pharma USA Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=095630bd-a77e-434e-94ee-f13da445d8f2

Nov 26th, 2021 - RECENT MAJOR CHANGES SECTION Warnings and Precautions (5.3, 5.4) 2/2021 Boxed Warning Section Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Risperidone tablets are not approved for the treatment of patients with dementia-related psychosis. [see Warnings and Precautions (5.1)] WARNING: INCREASED MORTALITY IN ELDERLY PATIENT...

At what age should the Uyghur minority initiate cervical cancer screening if screened u...
https://doi.org/10.1002/cam4.4409
Cancer Medicine; Abulizi G, Mijiti P et. al.

Nov 25th, 2021 - The careHPV test as a primary screening method for cervical cancer has been proven to be the best option for Uyghur women in Xinjiang in a previous study. In this research, we aim to discuss the appropriate age for Uyghur women in Xinjiang to be screened for cervical cancer using careHPV. Eleven thousand women aged 20-69 years old (mean age 38.93 ± 9.74) from South Xinjiang were screened using ...

Late-Stage Pancreatic Cancer Detected During High-Risk Individual Surveillance: A Syste...
https://doi.org/10.1053/j.gastro.2021.11.021
Gastroenterology Chhoda A, Vodusek Z et. al.

Nov 24th, 2021 - Identification and resection of successful targets, i.e., T1 N0M0 pancreatic ductal adenocarcinoma (PDAC) and high-grade precursors during surveillance of high-risk individuals (HRIs) confers improved survival. Late-stage PDACs refer to T2-4 N0M0 and nodal or distant metastatic PDAC stages diagnosed during the follow-up phase of HRI surveillance. This study aimed to quantify late-stage PDACs du...

Tumor Syndromes: Neurosurgical Evaluation and Management.
https://doi.org/10.1016/j.nec.2021.09.007
Neurosurgery Clinics of North America; Ganapathy A, Diaz EJ et. al.

Nov 22nd, 2021 - There are multiple syndromes associated with tumors of the central nervous system (CNS). The most common CNS tumor syndrome is neurofibromatosis-1, with well-defined major and minor criteria needed for diagnosis. Other syndromes with variable degree of CNS and extra-CNS involvement that the neurosurgeon should be aware of include neurofibromatosis-2; Turcot syndrome; Cowden syndrome; Gorlin syn...

Omeprazole and sodium bicarbonate - omeprazole and sodium bicarbonate for suspension-Ajanta Pharma USA Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bd84ca00-6352-4cb3-bce2-05f4a5005a94

Nov 22nd, 2021 - Recent Major Changes Section Warnings and Precautions, Acute Tubulointerstitial Nephritis (5.2) 11/2020 Indications & Usage Section Omeprazole and Sodium Bicarbonate for oral suspension is indicated in adults for the: short-term treatment of active duodenal ulcer. Most patients heal within four weeks. Some patients may require an additional four weeks of therapy. short-term treatment (4 to 8 ...

Omeprazole and sodium bicarbonate - omeprazole and sodium bicarbonate capsule-Ajanta Pharma USA Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cb657607-b038-47ee-b4e7-a5f419a14c33

Nov 22nd, 2021 - Recent Major Changes Section Warnings and Precautions, Acute Tubulointerstitial Nephritis (5.2) 11/2020 Indications & Usage Section Omeprazole and Sodium Bicarbonate capsules are indicated in adults for the: short-term treatment of active duodenal ulcer. Most patients heal within four weeks. Some patients may require an additional four weeks of therapy. short-term treatment (4 to 8 weeks) of ...

CHIP/CCUS Natural History Protocol
https://clinicaltrials.gov/ct2/show/NCT04102423

Nov 22nd, 2021 - Clonal Hematopoiesis of Indeterminate Potential (CHIP) has been defined as the presence of a somatic pathogenic variant associated with hematological malignancy, with an allele fraction of at least 2%, without morphological evidence of bone marrow dysplasia or neoplasia. Such variants are small, occur in leukocytes and are found in a substantial proportion of the healthy aging population using ...

REVEAL 2 Trial (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)
https://clinicaltrials.gov/ct2/show/NCT03721978

Nov 22nd, 2021 - HPV-303 is a prospective, randomized, double-blind, placebo-controlled phase 3 study of VGX-3100 delivered intramuscularly (IM) followed by electroporation (EP) delivered with CELLECTRA™ 5PSP in adult women with histologically confirmed high-grade squamous intraepithelial lesions (HSIL) (cervical intraepithelial neoplasia grade 2 [CIN2] or grade 3 [CIN3]) of the cervix, associated with HPV-16 a...

Centralized surveillance of hydatidiform mole: 7-year experience from a regional hospit...
https://doi.org/10.1136/ijgc-2021-002797
International Journal of Gynecological Cancer : Official ... Jiao L, Wang Y et. al.

Nov 21st, 2021 - To assess the strategy and value of centralized surveillance of hydatidiform mole at a regional hospital in China and to investigate the necessity of prophylactic chemotherapy for high-risk complete hydatidiform mole. Between February 2013 and February 2020, all women with hydatidiform mole in Dalian Women's and Children's Medical Center (Group) were registered for surveillance and treatment wh...

Can biopsies be omitted after normal colposcopy in women referred with low-grade cervic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603470
BMC Women's Health; Jespersen MM, Booth BB et. al.

Nov 21st, 2021 - Controversy surrounds whether women with low-risk cytology screening results but a normal colposcopic assessment should have random biopsies taken. The aim of this study was to determine the yield of CIN2+ from one to four cervical biopsies in women with cytology of LSIL or ASCUS and a normal colposcopic impression. Between January 2017 and September 2020, women over 18 years old referred for c...

Chemoprevention Considerations in Patients with Hereditary Colorectal Cancer Syndromes.
https://doi.org/10.1016/j.giec.2021.08.005
Gastrointestinal Endoscopy Clinics of North America; Macaron C, Mankaney GN et. al.

Nov 21st, 2021 - Secondary prevention of colorectal neoplasia with chemoprevention is long-studied area of research and clinical use in patients with the 2 most common hereditary colorectal cancer syndromes including Lynch syndrome and familial adenomatous polyposis. No medication is currently approved for use for the prevention of colorectal polyps or cancer in either the general population or individuals with...

Colorectal Cancer Screening Recommendations and Outcomes in Lynch Syndrome.
https://doi.org/10.1016/j.giec.2021.08.001
Gastrointestinal Endoscopy Clinics of North America; Drogan C, Kupfer SS

Nov 21st, 2021 - Screening for colorectal cancer (CRC) in Lynch syndrome enables early detection and likely cancer prevention. CRC screening guidelines have evolved from universal to gene-specific recommendations based on lifetime neoplasia risks. Regular screening for Lynch syndrome reduces CRC-related mortality; however, high CRC incidence during regular colonoscopy screening suggests the possibility of nonpo...