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About 810,823 results

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Fauci in the Doghouse; SCOTUS to Review Texas Abortion Law; Public Health's Downfall
https://www.medpagetoday.com/infectiousdisease/covid19/95235

Oct 25th, 2021 - Note that some links may require registration or subscription. NIH officials admitted that they funded research to the Wuhan Institute of Virology that enhanced bat coronaviruses, but insisted there were too many genetic differences for one of those viruses to have led to the origin of the COVID pandemic. (Vanity Fair) Meanwhile, 24 legislators sent a letter to NIAID Director Anthony Fauci, MD,...

Psoriasis patients with more severe disease at higher risk of developing PsA
https://www.mdedge.com/dermatology/article/247833/psoriatic-arthritis/psoriasis-patients-more-severe-disease-higher-risk

Oct 24th, 2021 - Key clinical point: Patients with psoriasis with the most severe disease were at highest risk of developing psoriatic arthritis (PsA), highlighting the need for regular screening for signs and symptoms of PsA. Major finding: Overall incidence of PsA in patients with mild, moderate, and severe psoriasis was 2.

PsA: Phase 3 confirms rapid and significant response of secukinumab on synovitis
https://www.mdedge.com/dermatology/article/247831/psoriatic-arthritis/psa-phase-3-confirms-rapid-and-significant-response

Oct 24th, 2021 - Key clinical point: Evaluation with power Doppler ultrasound revealed a rapid and significant reduction of synovitis in patients with psoriatic arthritis (PsA) upon treatment with secukinumab. Major finding : At week 12, the adjusted mean change in the global European League Against Rheumatism (EULAR) and the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) (EULAR-OMERACT) syn.

Risk classification at diagnosis predicts post-HCT outcomes in AML
https://www.mdedge.com/hematology-oncology/article/247827/aml/risk-classification-diagnosis-predicts-post-hct-outcomes-aml

Oct 24th, 2021 - Key clinical point: Risk classification at acute myeloid leukemia (AML) diagnosis predicted clinical outcomes in patients with or without KMT2A-rearranged AML who underwent allogeneic hematopoietic cell transplant (HCT) in the first complete remission (CR1). Major finding: Transplanted patients with KMT2A-rearranged and adverse-risk AML had worse overall survival (hazard ratio [HR] 1.

LDL cholesterol target achievement in heterozygous familial hypercholesterolemia patien...
https://doi.org/10.1016/j.ijcard.2021.10.024
International Journal of Cardiology; Rizos CV, Skoumas I et. al.

Oct 24th, 2021 - The 2019 European guidelines (ESC/EAS) for the treatment of dyslipidaemias recommend more aggressive targets for low-density lipoprotein cholesterol (LDL-C) in patients with familial hypercholesterolemia (FH). Current lipid-lowering treatment is often inadequate to achieve these targets. Data from the HELLAS-FH registry were analysed to assess achievement of LDL-C targets in adults with FH base...

Intestinal obstruction secondary to malformation in a child with Mayer-Rokitansky-Küste...
https://doi.org/10.1016/j.jpag.2021.10.002
Journal of Pediatric and Adolescent Gynecology; Tan LJ, Tan GC et. al.

Oct 24th, 2021 - Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is a congenital disorder characterized by underdevelopment of the uterus and vagina. A 4-year-old girl was declared dead on arrival to the hospital with a history of chronic constipation since birth. Postmortem examination showed Müllerian remnants attached to abnormal fibrous tissue. The fibrous tissue extended from the descending colon to the rec...

Awake microsurgical resection for optochiasmatic cavernous malformation.
https://doi.org/10.1016/j.wneu.2021.10.104
World Neurosurgery; Alejandro SA, Paganelli SL et. al.

Oct 24th, 2021 - The cavernous malformations (CM) affect approximately 0.5% of the population, with only a limited portion being located in the optic nerve and chiasma. The clinical presentation is determined by their locations. In the optochiasmatic CM, the acute visual disturbance is the most common presentation. Chronically, many show a progressive visual loss, chronic headache, and pituitary disturbances. T...

Mitochondrial Iron-Sulfur Cluster Biogenesis and Neurological Disorders.
https://doi.org/10.1016/j.mito.2021.10.004
Mitochondrion Selvanathan A, Parayil Sankaran B

Oct 24th, 2021 - Iron-sulfur clusters (ISCs) are highly conserved moieties embedded into numerous crucial proteins in almost all bacteria, plants and mammals. As such, ISC biosynthesis is critical to cellular function. The pathway was first characterized in bacteria by the late 1990s, and over the subsequent 20 years there has been increasing understanding of its components in humans. Defects in ISC pathway com...

Metabolic syndrome and risk of gastrointestinal cancers: an investigation using large-s...
https://doi.org/10.1016/j.cgh.2021.10.016
Clinical Gastroenterology and Hepatology : the Official C... Rothwell JA, Jenab M et. al.

Oct 24th, 2021 - Gastrointestinal cancer risk is influenced by the presence of metabolic syndrome [MetS]. However, previous epidemiological studies lacked full serological biomarker data for the classification of MetS and the interaction of MetS with germline cancer risk variants is unknown. We investigated the associations between MetS and gastrointestinal cancer risk (overall, colorectal, pancreatic, esophage...

Evidence for retained spike-binding and neutralizing activity against emerging SARS-CoV...
https://doi.org/10.1016/j.ebiom.2021.103626
EBioMedicine Carreño JM, Alshammary H et. al.

Oct 24th, 2021 - Highly efficacious vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed. However, the emergence of viral variants that are more infectious than the earlier SARS-CoV-2 strains is concerning. Several of these viral variants have the potential to partially escape neutralizing antibody responses, warranting continued immune-monitoring. We used a panel of...

Non-alcoholic fatty liver disease: Current therapeutic options.
https://doi.org/10.1016/j.coph.2021.09.007
Current Opinion in Pharmacology; Majumdar A, Verbeek J et. al.

Oct 24th, 2021 - Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and has an estimated global prevalence of 25%. NAFLD is found in up to 80% of people with obesity and over 60% of patients with diabetes. Cardiovascular disease is the main cause of mortality, followed by extra-hepatic cancers and then liver-specific complications of cirrhosis and hepatocellular carcinoma...

Efficacy and Safety of CT-P10 Versus Rituximab in Untreated Low-Tumor-Burden Follicular...
https://doi.org/10.1016/j.clml.2021.08.005
Clinical Lymphoma, Myeloma & Leukemia; Kwak LW, Sancho JM et. al.

Oct 24th, 2021 - This double-blind, parallel-group, active-controlled phase III trial (NCT02260804) assessed CT-P10 and rituximab safety and efficacy in patients with previously untreated low-tumor-burden follicular lymphoma (LTBFL), including after a single switch from rituximab to CT-P10. LTBFL patients were randomized (1:1) to receive CT-P10 or rituximab (375 mg/m2 intravenously; day 1 of 4 7-day cycles). Pa...

Validation of AML-score in Older Adults Receiving CPX-351 Intensive Induction Chemother...
https://doi.org/10.1016/j.clml.2021.09.016
Clinical Lymphoma, Myeloma & Leukemia; Schmucker AM, Leiby BE et. al.

Oct 24th, 2021 - The AML-Score has been validated in patients receiving traditional induction chemotherapies but not CPX-351. We conducted a retrospective analysis to evaluate, among patients with secondary acute myeloid leukemia who received intensive induction with CPX-351, if the AML-Score associates with (1) complete remission (CR) and (2) early mortality (EM) within 60 days of induction. We abstracted demo...

Sleep in children and young adults with cystic fibrosis.
https://doi.org/10.1016/j.prrv.2021.09.006
Paediatric Respiratory Reviews; Fauroux B, Waters K et. al.

Oct 24th, 2021 - Large gains have been made in the management of respiratory diseases associated with cystic fibrosis (CF). Initial studies evaluating sleep issues in CF focused on respiratory problems of nocturnal hypoxia, alveolar hypoventilation and risk of airway obstruction from nasal polyps with treatment evaluations including long term oxygen therapy or noninvasive ventilation in case of nocturnal hyperc...

Second Autologous Stem Cell Transplant as Salvage in Multiple Myeloma - The Oregon Heal...
https://doi.org/10.1016/j.clml.2021.08.008
Clinical Lymphoma, Myeloma & Leukemia; Galligan D, Williamson S et. al.

Oct 24th, 2021 - Second autologous transplants (SAT) are routinely performed in the setting of myeloma relapse, though data on outcomes are lacking. We conducted a single-center review of all multiple myeloma patients at OHSU who received SAT (excluding tandems) with responses assessed by International Myeloma Working Group (IMWG) criteria. Sixty-eight patients received SAT between 1999 and 2019. Risk by IMWG w...

How Does Female Sex Affect Complex Endovascular Aortic Repair? A Single Centre Cohort S...
https://doi.org/10.1016/j.ejvs.2021.08.034
European Journal of Vascular and endoVascular Surgery : T... Behrendt CA, Panuccio G et. al.

Oct 24th, 2021 - There is growing evidence of a female patient disadvantage in complex endovascular aortic repair using fenestrated and branched endografts (FB-EVAR) primarily related to peri-procedural events including ischaemic and access vessel complications. This study aimed to determine the impact of sex differences on treatment patterns, and in hospital outcomes in a single centre cohort. This was a retro...

Two-dose COVID-19 vaccination and possible arthritis flare among patients with rheumato...
https://doi.org/10.1136/annrheumdis-2021-221571
Annals of the Rheumatic Diseases; Li X, Tong X et. al.

Oct 24th, 2021 - To investigate the relationship between COVID-19 full vaccination (two completed doses) and possible arthritis flare. Patients with rheumatoid arthritis (RA) were identified from population-based electronic medical records with vaccination linkage and categorised into BNT162b2 (mRNA vaccine), CoronaVac (inactive virus vaccine) and non-vaccinated groups. The risk of possible arthritis flare afte...

Intracellular Adhesion Molecule-1 (ICAM-1) Levels in Convalescent COVID-19 Serum: A Cas...
https://www.ncbi.nlm.nih.gov/pubmed/34686518
Annals of Clinical and Laboratory Science; Smith-Norowitz TA, Loeffler J et. al.

Oct 24th, 2021 - Intercellular adhesion molecule-1 (ICAM-1), an endothelial cell adhesion molecule, contributes to inflammation and immune-mediated responses. Viral infection of endothelial cells caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause vascular changes and elevate the expression of ICAM-1 in coronavirus disease 2019 (COVID-19) patients and may be used as a biomarker to m...

Durable Cord Blood Cell Engraftment in a Patient with Severe Aplastic Anemia after a Ma...
https://www.ncbi.nlm.nih.gov/pubmed/34686517
Annals of Clinical and Laboratory Science; Wei ZL, Huang LQ et. al.

Oct 24th, 2021 - Severe aplastic anemia (SAA) is a fatal bone marrow failure disease. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) with a matched sibling donor is the first-line treatment for older SAA patients. However, the number of CD34+ cells collected from a matched donor is often lower than expected. To overcome the problem, this study was conducted to combine a matched sibling donor wit...