×
About 1,675,350 results

Germline Variants Identified in Patients with Early-onset Renal Cell Carcinoma Referred for Germline Genetic Testing
https://pubmed.ncbi.nlm.nih.gov/34654685/
European Urology Oncology; Truong H

Oct 12th, 2021 - Despite guidelines recommending genetic counseling for patients with early-onset renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations and clinical associations in patients with early-onset RCC are lacking.

Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants
https://www.biorxiv.org/content/10.1101/2021.07.19.452771v1
BioRxiv Tada T, Zhou H et. al.

Jul 19th, 2021 - The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible decreases in vaccine efficacy. Here, neutralizing antibody titers elicited by mRNA-based and an adenoviral vector-based vaccine against variant pseudotyped viruses were compared.

DSHS Statement on Monkeypox Investigation
https://www.dshs.texas.gov/news/releases/2021/20210716.aspx
Texas Health and Human Services

Jul 16th, 2021 - The Texas Department of State Health Services is working with Dallas County Health and Human Services and the CDC to investigate a single case of monkeypox virus infection in a Dallas County resident who recently returned from Nigeria. The patient is isolated in the hospital, and the public health investigation has identified a few people who may have been exposed in Dallas and are monitoring t...

CDC and Texas Confirm Monkeypox In U.S. Traveler
https://www.cdc.gov/media/releases/2021/s0716-confirm-monkeypox.html
Centers for Disease Control and Prevention (CDC)

Jul 16th, 2021 - The Centers for Disease Control and Prevention (CDC) and the Texas Department of State Health Services confirmed on July 15 a case of human monkeypox in a U.S. resident who recently traveled from Nigeria to the United States. The person is currently hospitalized in Dallas. CDC is working with the airline and state and local health officials to contact airline passengers and others who may have ...

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report
https://www.medrxiv.org/content/10.1101/2021.10.10.21264827v1.full.pdf
Medrxiv Atmar RL, .

Oct 13th, 2021 - Background: While Coronavirus disease 2019 (Covid-19) vaccines are highly effective, breakthrough infections are occurring. Booster vaccinations have recently received emergency use authorization (EUA) for certain populations but are restricted to homologous mRNA vaccines. We evaluated homologous and heterologous booster vaccination in persons who had received an EUA Covid-19 vaccine regimen.

Continuous-Release Anti-VEGF Device for AMD Wins FDA Approval
https://www.medpagetoday.com/ophthalmology/generalophthalmology/95225

Oct 23rd, 2021 - The FDA has approved a first-of-its kind continuous delivery system for anti-VEGF therapy for neovascular (wet) age-related macular degeneration (AMD). The Susvimo ocular implant continuously releases 100 mg/mL of ranibizumab directly to the retina over 6 months. Initial implantation and refill can be performed during an office visit with an ophthalmologist. In contrast, conventional intravitre...

Implantable Cardioverter-Defibrillator Therapies and Pulmonary Valve Replacement for Te...
https://doi.org/10.1016/j.jacep.2021.03.014
JACC. Clinical Electrophysiology; Moore JP

Oct 23rd, 2021 - Implantable Cardioverter-Defibrillator Therapies and Pulmonary Valve Replacement for Tetralogy of Fallot.|2021|Moore JP,|

Parkinsonism and cerebrospinal fluid disorders.
https://doi.org/10.1016/j.jns.2021.120019
Journal of the Neurological Sciences; Youn J, Todisco M et. al.

Oct 23rd, 2021 - Although various motor manifestations can be seen in patients with cerebrospinal fluid (CSF) disorders, such as hydrocephalus or intracranial hypotension, the clinical presentation with parkinsonism is not clearly elucidated. We searched the literature for studies describing the occurrence of parkinsonism in subjects with normal pressure hydrocephalus (NPH), obstructive hydrocephalus, and intra...

Right Ventricular-Pulmonary Arterial Coupling in Patients With HF Secondary MR: Analysi...
https://doi.org/10.1016/j.jcin.2021.07.047
JACC. Cardiovascular Interventions; Brener MI, Grayburn P et. al.

Oct 23rd, 2021 - The aim of this study was to determine the prognostic impact of right ventricular (RV)-pulmonary arterial (PA) coupling in patients with heart failure (HF) with severe secondary mitral regurgitation (SMR) enrolled in the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation) trial. RV contractile function ...

Impact of Transcatheter Mitral Valve Repair on Preprocedural and Postprocedural Hospita...
https://doi.org/10.1016/j.jcin.2021.08.007
JACC. Cardiovascular Interventions; Czarnecki A, Han L et. al.

Oct 23rd, 2021 - The objective of this study was to determine the effect of transcatheter mitral valve repair (TMVr) on hospitalization rates by assessing pre- and postprocedural hospitalization patterns. TMVr has emerged as the treatment of choice for selected patients with mitral regurgitation, but the impact of these procedures on hospital utilization remains unclear. All patients who underwent TMVr in Ontar...

Vestibular functions in patients with idiopathic sudden sensorineural hearing loss and ...
https://doi.org/10.1016/j.anl.2021.09.009
Auris, Nasus, Larynx; Kizkapan DB, Karlidag T et. al.

Oct 23rd, 2021 - Because of the anatomically close relationship between the cochlea and the vestibular organs, cochlear function disorders may be accompanied by vestibular disorders. This study aimed to evaluate vestibular functions in patients with idiopathic sudden sensorineural hearing loss using VEMP, caloric test, and VNG test battery and its relation to prognosis. For this study, 42 patients aged 18-55 ye...

Functional outcomes after submandibular gland-sparing neck dissection in patients with ...
https://doi.org/10.1016/j.ijom.2021.09.009
International Journal of Oral and Maxillofacial Surgery; Gu H, Xuan G et. al.

Oct 23rd, 2021 - The feasibility of submandibular gland (SMG) preservation during neck dissection has been described. The aim of this study was to analyse the functional outcomes in patients undergoing SMG preservation during neck dissection for cT1-2N0 oral squamous cell carcinoma. Consecutive patients were divided into two groups based on the management of the SMG, and underwent a saliva flow test before surg...

Differential impact of physical distancing strategies on social contacts relevant for t...
https://doi.org/10.1136/bmjopen-2021-050651
BMJ Open; Del Fava E, Cimentada J et. al.

Oct 23rd, 2021 - We investigate changes in social contact patterns following the gradual introduction of non-pharmaceutical interventions and their implications for infection transmission in the early phase of the pandemic. We conducted an online survey based on targeted Facebook advertising campaigns across eight countries (Belgium, France, Germany, Italy, the Netherlands, Spain, UK and USA), achieving a sampl...

Leveraging immune memory against measles virus as an antitumor strategy in a preclinica...
https://doi.org/10.1136/jitc-2020-002170
Journal for Immunotherapy of Cancer; Leb-Reichl VM, Kienzl M et. al.

Oct 23rd, 2021 - Viral antigens are among the strongest elicitors of immune responses. A significant proportion of the human population already carries pre-existing immunity against several childhood viruses, which could potentially be leveraged to fight cancer. We sought to provide proof of concept in mouse models that a pre-existing measles virus (MeV) immunity can be redirected to inhibit tumor growth by dir...

Impact of the SARS-CoV-2 pandemic on access to contraception and pregnancy intentions: ...
https://doi.org/10.1136/bmjsrh-2021-201164
BMJ Sexual & Reproductive Health; Balachandren N, Barrett G et. al.

Oct 23rd, 2021 - Evaluate the impact of the COVID-19 pandemic on access to contraception and pregnancy intentions. Nationwide prospective cohort study. United Kingdom. Women in the UK who were pregnant between 24 May and 31 December 2020. Access to contraception and level of pregnancy intentions, using the London Measure of Unplanned Pregnancy (LMUP) in women whose last menstrual period was before or after 1 Ap...

Effect of Levetiracetam Use Duration on Overall Survival of Isocitrate Dehydrogenase Wi...
https://doi.org/10.1212/WNL.0000000000013005
Neurology Pallud J, Huberfeld G et. al.

Oct 23rd, 2021 - The association between Levetiracetam and survival of Isocitrate Dehydrogenase (IDH) wildtype glioblastomas is controversial. We investigated whether the duration of Levetiracetam use during the standard chemoradiation protocol impacts overall survival of IDH-wildtype glioblastoma patients. Observational single-institution cohort study (2010-2018). Inclusion criteria were: 1) patients ≥18 years...

Clinical Reasoning: Progressive Proximal Weakness in a 61-Year-Old Male.
https://doi.org/10.1212/WNL.0000000000013000
Neurology Yu M, Bitar M et. al.

Oct 23rd, 2021 - A 61-year-old man presents with painless progressive weakness and was found to have myopathy both clinically and on diagnostic workup.The etiology of his myopathy is the first reported case of anti-SRP myopathy and sarcoidosis overlap syndrome. The high titer anti-SRP antibody and phenotype support the diagnosis of an overlap syndrome, defined as multiple distinct autoimmune diseases occurring ...

GGC Repeat Expansion of NOTCH2NLC in Taiwanese Patients With Inherited Neuropathies.
https://doi.org/10.1212/WNL.0000000000013008
Neurology Liao YC, Chang FP et. al.

Oct 23rd, 2021 - The GGC repeat expansion in the 5' untranslated region of NOTCH2NLC was recently identified as the cause of neuronal intranuclear inclusion disease (NIID), which may manifest with peripheral neuropathy. The aim of this study is to investigate its contribution to inherited neuropathy. This cohort study screened patients with molecularly undiagnosed Charcot-Marie-Tooth disease (CMT) and healthy c...

NOTCH2NLC-related disorders: the widening spectrum and genotype-phenotype correlation.
https://doi.org/10.1136/jmedgenet-2021-107883
Journal of Medical Genetics; Fan Y, Xu Y et. al.

Oct 23rd, 2021 - GGC repeat expansion in the 5' untranslated region of NOTCH2NLC is the most common causative factor in neuronal intranuclear inclusion disease (NIID) in Asians. Such expanded GGC repeats have been identified in patients with leukoencephalopathy, essential tremor (ET), multiple system atrophy, Parkinson's disease (PD), amyotrophic lateral sclerosis and oculopharyngodistal myopathy (OPDM). Herein...