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About 310,375 results

ROS1-positive Inflammatory Myofibroblastic Tumor of the Small Bowel Causing Obstruction...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063829
Journal of Radiology Case Reports; Budylev A, Solar I et. al.

May 20th, 2022 - Inflammatory Myofibroblastic Tumors (IMTs) are rare fibroblastic/myofibroblastic neoplasms that affect predominately pediatric patients and young adults. Almost half of the patients with IMTs have a chromosomal abnormality in the Anaplastic Lymphoma Kinase 1 gene on chromosome 2p23. Although these tumors occur primarily in the lung, lesions have been reported in a variety of intra-abdominal org...

Novel Diagnostic Value of Driver Gene Transcription Signatures to Characterise Clear Ce...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108154
Pathology Oncology Research : POR; Ujfaludi Z, Kuthi L et. al.

May 20th, 2022 - Routine molecular tumour diagnostics are augmented by DNA-based qualitative and quantitative molecular techniques detecting mutations of DNA. However, in the past decade, it has been unravelled that the phenotype of cancer, as it's an extremely complex disease, cannot be fully described and explained by single or multiple genetic variants affecting only the coding regions of the genes. Moreover...

IL-17: an important pathogenic factor in endometriosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108413
International Journal of Medical Sciences; Shi JL, Zheng ZM et. al.

May 19th, 2022 - Interleukin-17 (IL-17) is known as a Th17-cell-derived proinflammatory cytokine, which plays a pivotal role in several inflammatory and autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis, and psoriasis. Emerging evidence has shown that IL-17 is linked to endometriosis, although the etiology of endometriosis is still unknown. The IL-17 expression is up-regulated...

Novel approaches in search for biomarkers of cholangiocarcinoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048460
World Journal of Gastroenterology; Mocan LP, Ilieș M et. al.

May 19th, 2022 - Cholangiocarcinoma (CCA) arises from the ductular epithelium of the biliary tree, either within the liver (intrahepatic CCA) or more commonly from the extrahepatic bile ducts (extrahepatic CCA). This disease has a poor prognosis and a growing worldwide prevalence. The poor outcomes of CCA are partially explained by the fact that a final diagnosis is challenging, especially the differential diag...

Lipid metabolism-related gene prognostic index (LMRGPI) reveals distinct prognosis and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108406
International Journal of Medical Sciences; Jiang A, Chen X et. al.

May 19th, 2022 - Background: Lipid metabolism plays a pivotal role in cancer progression and metastasis. This study aimed to investigate the prognostic value of lipid metabolism-related genes (LMRGs) in early-stage lung adenocarcinoma (LUAD) and develop a lipid metabolism-related gene prognostic index (LMRGPI) to predict their overall survival (OS) and treatment response. Methods: A total of 774 early-stage LUA...

Identification and validation of the N6-methyladenosine RNA methylation regulator ZC3H1...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108408
International Journal of Medical Sciences; Wu S, He G et. al.

May 19th, 2022 - N6-methyladenosine (m6A) RNA methylation has been implicated in various malignancies. This study aimed to identify prognostic signature based on m6A methylation regulators for hepatocellular carcinoma (HCC) and provide candidate targets for HCC treatment. In this study, the expression levels, prognostic values, correlation with tumor grades and genetic variations of m6A-related genes in HCC wer...

Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats b...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108400
International Journal of Medical Sciences; Yu M, Wu X et. al.

May 19th, 2022 - Pulmonary arterial hypertension (PAH) characterized by pulmonary vascular remodeling is a lethal disease. Paeoniflorin (PF) is a monoterpene glycoside with numerous beneficial functions, such as vasodilation, anti-inflammation and immunomodulation. This study aims to investigate the effects of PF on monocrotaline (MCT)-induced PAH rats. Our data showed that both prophylactic or therapeutic admi...

Differences in the expression of DNA methyltransferases and demethylases in leukocytes ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114656
Physiological Reports; D'Addario CA, Lanier GM et. al.

May 19th, 2022 - The loss of ten-eleven translocation (TET2) methylcytosine dioxygenase expression contributes to the pathobiology of pulmonary arterial hypertension (PAH). However, whether the expression and activity of other TETs and DNA methyltransferases (DNMTs) are altered in PAH remains enigmatic. Therefore, our objective was to determine the expression of DNMT (1, 3a, and 3b) and TET (1, 2, and 3) and th...

Hedgehog Signaling Pathway Proteins in Prognosis of Pancreatic Ductal Adenocarcinoma an...
https://doi.org/10.1097/MPA.0000000000002001
Pancreas Winter K, Dzieniecka M et. al.

May 19th, 2022 - The Hedgehog signaling pathway (Hh) probably plays a role in development and progression of pancreatic ductal adenocarcinoma (PDAC). In our study, 114 patients (83 with PDAC and 31 with chronic pancreatitis [CP]) after pancreatic surgery were enrolled. The immunoexpression of Sonic hedgehog (Shh), Smoothened (Smo), and Glioblastoma transcription factor 1 (Gli1) and Ki-67 were detected in tissue...

Diagnostic gene biomarkers for predicting immune infiltration in endometriosis.
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BMC Women's Health; Xie C, Lu C et. al.

May 19th, 2022 - To determine the potential diagnostic markers and extent of immune cell infiltration in endometriosis (EMS). Two published profiles (GSE7305 and GSE25628 datasets) were downloaded, and the candidate biomarkers were identified by support vector machine recursive feature elimination analysis and a Lasso regression model. The diagnostic value and expression levels of biomarkers in EMS were verifie...

Downregulation of angiogenic factors in aqueous humor associated with less intraoperati...
https://doi.org/10.1186/s12886-022-02451-6 10.4103/ijo.IJO_1591_20 10.4103/ijo.IJO_1516_21 10.1186/s12886-019-1138-6 10.1007/s10792-019-01207-4 10.1038/s41598-018-32725-3 10.31083/j.fbl2701024 10.1136/bjophthalmol-2017-311344 10.1186/1471-2415-14-55 10.1167/iovs.14-15918 10.1080/09273948.2017.1327605 10.17116/oftalma2019135052299 10.1007/s12325-016-0461-z 10.18240/ijo.2021.03.20 10.1007/s10792-021-01846-6 10.2147/DDDT.S177192 10.1038/s41598-020-65833-0 10.1186/s12886-020-1321-9 10.1111/jebm.12379 10.1097/MD.0000000000009897 10.1016/j.jdiacomp.2020.107641 10.1167/iovs.09-4065 10.1016/j.cyto.2012.07.005 10.1097/IAE.0b013e3182979df6 10.1016/j.ajo.2019.05.007 10.21037/apm.2020.01.10 10.1186/s12886-022-02303-3 10.1038/s41433-021-01474-5 10.1016/j.diabres.2020.108083 10.1016/j.bcp.2019.07.021 10.1007/s00417-019-04315-0
BMC Ophthalmology; Xu Q, Gong C et. al.

May 19th, 2022 - To analyze the level changes of 28 cytokines in aqueous humor of patients with proliferative diabetic retinopathy (PDR) coexisting neovascular glaucoma (NVG) after intravitreal injection of conbercept (IVC), and to investigate whether these cytokines are associated with intraoperative bleeding (IOB). Totally 34 eyes with NVG secondary to PDR were enrolled. Patients were randomized into two grou...

Age modifies both the maximal temperature and inflammatory response in patients with SA...
https://doi.org/10.7861/clinmed.2021-0603
Clinical Medicine (London, England); Crooks CJ, West J et. al.

May 19th, 2022 - To determine the maximal response of the temperature and inflammatory response to SARS-CoV-2 infection and how these are modified by age. Participants were patients admitted to hospital with SARS-CoV-2 infection. For each participant, the maximal temperature and serum C-reactive protein (CRP) were identified and stratified by age. In a secondary analysis, these were compared in patients treated...

Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and...
https://doi.org/10.1038/s41467-022-30443-z 10.1038/nn1172 10.1038/nrm1739 10.1093/brain/aws019 10.1016/S1474-4422(14)70040-7 10.3389/fncel.2015.00030 10.1016/j.semcdb.2017.09.031 10.1212/WNL.55.11.1603 10.1148/radiology.182.2.1732969 10.1016/S0896-6273(00)80651-0 10.1093/brain/awl125 10.1111/jnc.14338 10.1038/nn1172 10.1038/nn.2553 10.1038/nature08845 10.1093/cercor/bhq238 10.1523/JNEUROSCI.4773-10.2011 10.1038/nn.2807 10.15252/embr.201642292 10.3389/fncel.2015.00062 10.1038/nn.3729 10.1002/ana.24964 10.1038/s41598-017-15253-4 10.1016/j.celrep.2019.06.096 10.1186/s13041-017-0324-9 10.1523/JNEUROSCI.18-04-01217.1998 10.1016/j.neuron.2018.01.052 10.1038/nmeth0810-575 10.1038/nmeth.3213 10.1038/nmeth.2890 10.1016/j.neuron.2019.06.011 10.1126/science.aad8361 10.1016/S0896-6273(00)80777-1 10.1074/jbc.272.18.11943 10.1016/0896-6273(94)90341-7 10.1016/j.ajhg.2012.04.008 10.1038/35046087 10.1083/jcb.201405060 10.1016/j.neuron.2011.12.030 10.3389/fncel.2014.00215 10.3389/fncel.2015.00099 10.1016/j.conb.2020.10.002 10.1016/0092-8674(95)90370-4 10.1111/ejn.13129 10.1016/j.tcb.2017.10.009 10.1128/MCB.18.10.5838 10.1101/cshperspect.a022442 10.1126/science.1187735 10.1371/journal.pbio.1002440 10.1038/ncb1183 10.1038/nature10163 10.1002/cpmo.48 10.1038/s41467-019-11431-2 10.1016/j.stem.2019.02.017 10.1016/j.tins.2020.07.009 10.1038/ncomms1155 10.1016/j.nbd.2015.08.003 10.1093/nar/gkw971 10.1093/hmg/ddu337 10.1093/cercor/bhn106 10.1523/JNEUROSCI.17-16-06236.1997 10.1242/dev.02330 10.1038/nn1744 10.1016/j.neuron.2006.10.024 10.1016/j.devcel.2017.05.002 10.1016/j.tcb.2017.10.009 10.1101/gad.1178004 10.1016/j.ydbio.2006.12.014 10.1186/s40478-017-0438-4 10.1007/s13760-018-0981-1 10.1016/S0896-6273(00)80809-0 10.1073/pnas.0609628104 10.1091/mbc.e02-11-0747 10.1128/MCB.25.20.8948-8959.2005 10.1038/ncb1673 10.1083/jcb.201002151 10.1242/jcs.051011 10.1371/journal.pbio.3001279 10.1001/jamaneurol.2016.0363 10.1016/j.celrep.2017.11.106 10.1038/ng.3676 10.1038/s41398-018-0327-z 10.1038/nature07287 10.1073/pnas.0610155104 10.1373/clinchem.2008.112797 10.1523/JNEUROSCI.6716-10.2011
Nature Communications; Romero DM, Poirier K et. al.

May 19th, 2022 - Subcortical heterotopias are malformations associated with epilepsy and intellectual disability, characterized by the presence of ectopic neurons in the white matter. Mouse and human heterotopia mutations were identified in the microtubule-binding protein Echinoderm microtubule-associated protein-like 1, EML1. Further exploring pathological mechanisms, we identified a patient with an EML1-like ...

Identification of Common Oncogenic Genes and Pathways Both in Osteosarcoma and Ewing's ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107040
Journal of Immunology Research; Zhang J, Huang J et. al.

May 18th, 2022 - This study was aimed at exploring common oncogenic genes and pathways both in osteosarcoma and Ewing's sarcoma. Microarray data were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using the limma package. Then, protein-protein interaction (PPI) networks were constructed and hub genes were identified. Furthermore, functional enrich...

Mitoribosomal defects aggravate liver cancer via aberrant glycolytic flux and T cell ex...
https://doi.org/10.1136/jitc-2021-004337
Journal for Immunotherapy of Cancer; Song BS, Moon JS et. al.

May 18th, 2022 - Mitochondria are involved in cancer energy metabolism, although the mechanisms underlying the involvement of mitoribosomal dysfunction in hepatocellular carcinoma (HCC) remain poorly understood. Here, we investigated the effects of mitoribosomal impairment-mediated alterations on the immunometabolic characteristics of liver cancer. We used a mouse model of HCC, liver tissues from patients with ...

Human liver single nucleus and single cell RNA sequencing identify a hepatocellular car...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115949
Genome Medicine; Alvarez M, Benhammou JN et. al.

May 18th, 2022 - Hepatocellular carcinoma (HCC) is a common primary liver cancer with poor overall survival. We hypothesized that there are HCC-associated cell-types that impact patient survival. We combined liver single nucleus (snRNA-seq), single cell (scRNA-seq), and bulk RNA-sequencing (RNA-seq) data to search for cell-type differences in HCC. To first identify cell-types in HCC, adjacent non-tumor tissue, ...

Dissecting the phenotypic variability of osteogenesis imperfecta.
https://doi.org/10.1242/dmm.049398
Disease Models & Mechanisms; Garibaldi N, Besio R et. al.

May 17th, 2022 - Osteogenesis imperfecta (OI) is a heterogeneous family of collagen type I-related diseases characterized by bone fragility. OI is most commonly caused by single-nucleotide substitutions that replace glycine residues or exon splicing defects in the COL1A1 and COL1A2 genes that encode the α1(I) and α2(I) collagen chains. Mutant collagen is partially retained intracellularly, impairing cell homeos...

Senescence-Associated miRNAs and Their Role in Pancreatic Cancer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098800
Pathology Oncology Research : POR; Popov A, Mandys V

May 17th, 2022 - Replicative senescence is irreversible cell proliferation arrest for somatic cells which can be circumvented in cancers. Cellular senescence is a process, which may play two opposite roles. On the one hand, this is a natural protection of somatic cells against unlimited proliferation and malignant transformation. On the other hand, cellular secretion caused by senescence can stimulate inflammat...

Metformin Improves the Prognosis of Adult Mice with Sepsis-Associated Encephalopathy Be...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095413
Journal of Immunology Research; Song G, Liang H et. al.

May 17th, 2022 - Sepsis-associated encephalopathy (SAE) is often associated with increased ICU occupancy and hospital mortality and poor long-term outcomes, with currently no specific treatment. Pathophysiological mechanisms of SAE are complex and may involve activation of microglia, multiple intracranial inflammatory factors, and inflammatory pathways. We hypothesized that metformin may have an effect on micro...

Benefits of aerobic exercise in myotonic dystrophy type 1.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106338
The Journal of Clinical Investigation; Mackenzie SJ, Hamel J et. al.

May 17th, 2022 - Myotonic dystrophy type 1 (DM1) is a multisystem trinucleotide repeat expansion disorder characterized by the misregulated alternative splicing of critical mRNAs. Previous work in a transgenic mouse model indicated that aerobic exercise effectively improves splicing regulation and function in skeletal muscle. In this issue of the JCI, Mikhail et al. describe the safety and benefits of applying ...