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About 279,233 results

Mitochondrial morphology is associated with respiratory chain uncoupling in autism spec...
https://doi.org/10.1038/s41398-021-01647-6 10.1016/j.spen.2020.100831 10.15585/mmwr.ss6904a1 10.1038/gim.2013.32 10.1038/ncomms6595 10.1186/s13229-020-00382-x 10.1001/jama.2015.10078 10.1038/nm.3792 10.1038/tp.2014.4 10.1002/bies.202000307 10.1001/archgenpsychiatry.2011.76 10.1001/jama.2014.4144 10.2217/bmm-2017-0109 10.1002/ajmg.b.30366 10.1371/journal.pone.0152249 10.3390/jpm11030218 10.1038/s41380-020-00885-2 10.1038/s41398-020-00905-3 10.1126/sciadv.aat1293 10.1016/j.cell.2012.02.035 10.1016/j.mito.2020.07.007 10.1016/j.mam.2019.10.003 10.1038/mp.2010.136 10.7156/v5i3p141 10.1001/jama.2010.1706 10.1542/peds.2013-1545 10.1371/journal.pone.0003815 10.1203/PDR.0b013e318212f16b 10.1177/0883073809342128 10.1002/acn3.51034 10.1038/tp.2012.143 10.1038/srep19544 10.1038/mp.2008.63 10.1038/s41598-017-04821-3 10.1038/tp.2015.29 10.1371/journal.pone.0085436 10.1155/2015/573701 10.3389/fpsyt.2019.00269 10.1038/s41398-017-0089-z 10.1096/fj.201601004R 10.1007/s11011-017-0087-0 10.2217/bmm.15.72 10.1016/j.spen.2013.10.008 10.1096/fj.201902677R 10.3390/ijms22158179 10.1016/j.neuint.2017.04.009 10.1007/s10803-014-2323-3 10.1007/s10803-011-1178-0 10.1007/s10803-010-1024-9 10.1111/j.1469-7610.2007.01762.x 10.1111/1469-7610.00114 10.1038/mp.2016.168 10.1007/s10803-013-1970-0 10.1016/j.ridd.2006.10.002 10.1016/S0891-4222(03)00055-6 10.1016/S0091-679X(06)80004-X 10.3389/fped.2017.00219 10.1038/srep35065 10.1038/tp.2012.61 10.1007/s40291-018-0352-x 10.1073/pnas.1414028111 10.1007/s00439-013-1322-3 10.1016/j.cell.2020.07.008 10.1080/15548627.2016.1277310 10.1186/s13041-016-0222-6 10.1089/cap.2016.0100 10.1016/j.braindev.2018.07.003 10.1212/WNL.0000000000007749 10.1016/j.neuroscience.2021.04.010 10.3389/fcell.2021.696428 10.1016/j.cbi.2019.108758 10.1016/j.ijdevneu.2019.05.006 10.1186/1742-2094-4-3 10.1186/s13229-018-0241-5 10.1016/j.psychres.2015.07.043 10.1016/j.pbb.2014.08.013 10.1016/j.neuropharm.2015.11.003 10.2217/bmm.13.158
Translational Psychiatry; Frye RE, Lionnard L et. al.

Oct 15th, 2021 - Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is associated with unique changes in mitochondrial metabolism, including elevated respiration rates and morphological alterations. We examined electron transport chain (ETC) complex activity in fibroblasts derived from 18 children with ASD as well as mitochondrial morphology measurements in fibroblasts derived from the ASD par...

Butyrophilin-like 9 expression is associated with outcome in lung adenocarcinoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507344
BMC Cancer; Ma W, Liang J et. al.

Oct 13th, 2021 - Lung adenocarcinoma (LUAD) is the most prevalent non-small cell lung cancer (NSCLC). Patients with LUAD have a poor 5-year survival rate. The use of immune checkpoint inhibitors (ICIs) for the treatment of LUAD has been on the rise in the past decade. This study explored the prognostic role of butyrophilin-like 9 (BTNL9) in LUAD. Gene expression profile of buytrophilins (BTNs) was determined us...

Histone methylation in pancreatic cancer and its clinical implications.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476335
World Journal of Gastroenterology; Liu XY, Guo CH et. al.

Oct 12th, 2021 - Pancreatic cancer (PC) is an aggressive human cancer. Appropriate methods for the diagnosis and treatment of PC have not been found at the genetic level, thus making epigenetics a promising research path in studies of PC. Histone methylation is one of the most complicated types of epigenetic modifications and has proved crucial in the development of PC. Histone methylation is a reversible proce...

Colonic expression of Ace2, the SARS-CoV-2 entry receptor, is suppressed by commensal h...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510562
Gut Microbes; Edwinson A, Yang L et. al.

Oct 12th, 2021 - Infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Angiotensin-converting enzyme 2 (Ace2) is expressed in the gastrointestinal (GI) tract and a receptor for SARS-CoV-2, making the GI tract a potential infection site. This study investigated the effects of commensal intestinal microbiota on colonic Ace2 expression using a humaniz...

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Inj...
https://doi.org/10.3791/57879
Journal of Visualized Experiments : JoVE; Üçal M, Haindl MT et. al.

Oct 12th, 2021 - Multiple sclerosis (MS) is the most common immune-mediated disease of the central nervous system (CNS) and progressively leads to physical disability and death, caused by white matter lesions in the spinal cord and cerebellum, as well as by demyelination in grey matter. Whilst conventional models of experimental allergic encephalomyelitis are suitable for the investigation of the cell-mediated ...

CircCDC45 promotes the malignant progression of glioblastoma by modulating the miR-485-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501713
BMC Cancer; Liu R, Dai W et. al.

Oct 11th, 2021 - Glioblastoma (GBM) is characterized by progressive growth and metastasis. Numerous studies claim that the deregulation of circular RNAs (circRNAs) is associated with cancer progression. However, the role of circRNAs in GBM is largely limited. The purpose of this study was to investigate the functions of circCDC45 in GBM and provide a feasible functional mechanism to support its role. The expres...

Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minire...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492288
Mediators of Inflammation; Vyavahare S, Kumar S et. al.

Oct 9th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs. Several studies have reported that the tryptophan-kynurenine pathway is altered in COVID-19 patients. The tryptophan-kynurenine pathway plays a vital role in regulating inflammation, metabolism, immune responses, an...

Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health cen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500452
PloS One; Maraqa B, Basha W et. al.

Oct 9th, 2021 - This study aimed to assess the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) total antibodies in the north, middle, and south regions of West Bank and the prevalence of SARS-CoV-2 specific antibodies (IgA, IgM, and IgG) in the Palestinian population. This was a cross-sectional study. The serological and epidemiological data of 1269 persons were assessed. Participant...

Rapid measurement of SARS-CoV-2 spike T cells in whole blood from vaccinated and natura...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409582
The Journal of Clinical Investigation; Tan AT, Lim JM et. al.

Oct 9th, 2021 - Defining the correlates of protection necessary to manage the COVID-19 pandemic requires the analysis of both antibody and T cell parameters, but the complexity of traditional tests limits virus-specific T cell measurements. We tested the sensitivity and performance of a simple and rapid SARS-CoV-2 spike protein-specific T cell test based on the stimulation of whole blood with peptides covering...

Inhaled D-Ala2-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Gro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490075
Journal of Immunology Research; Karkischenko VN, Skvortsova VI et. al.

Oct 8th, 2021 - COVID-19 is a respiratory infection caused by the SARS-CoV-2 virus that can rapidly escalate to life-threatening pneumonia and acute respiratory distress syndrome (ARDS). Recently, extracellular high mobility group box 1 (HMGB1) has been identified as an essential component of cytokine storms that occur with COVID-19; HMGB1 levels correlate significantly with disease severity. Thus, the modulat...

Wdr47, Camsaps, and Katanin cooperate to generate ciliary central microtubules.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490363
Nature Communications; Liu H, Zheng J et. al.

Oct 6th, 2021 - The axonemal central pair (CP) are non-centrosomal microtubules critical for planar ciliary beat. How they form, however, is poorly understood. Here, we show that mammalian CP formation requires Wdr47, Camsaps, and microtubule-severing activity of Katanin. Katanin severs peripheral microtubules to produce central microtubule seeds in nascent cilia. Camsaps stabilize minus ends of the seeds to f...

Effect of ORF7 of SARS-CoV-2 on the Chemotaxis of Monocytes and Neutrophils In Vitro.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483903
Disease Markers; Wang G, Guan J et. al.

Oct 5th, 2021 - Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the most significant public health threat worldwide. Patients with severe COVID-19 usually have pneumonia concomitant with local inflammation and sometimes a cytokine storm. Specific components of the SARS-CoV-2 virus trigger lung inflammation, and recruitment of immune ce...

Metabolic dysfunction associated fatty liver disease and coronavirus disease 2019: clin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487451
Lipids in Health and Disease; Xu Y, Yang X et. al.

Oct 5th, 2021 - The coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). At present, the COVID-19 has been prevalent worldwide for more than a year and caused more than four million deaths. Liver injury was frequently observed in patients with COVID-19. Recently, a new definition of metabolic dysfunction associated fatty liver disease (MAFLD) w...

Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486878
Nature Communications; Thery F, Martina L et. al.

Oct 3rd, 2021 - ISG15 is an interferon-stimulated, ubiquitin-like protein that can conjugate to substrate proteins (ISGylation) to counteract microbial infection, but the underlying mechanisms remain elusive. Here, we use a virus-like particle trapping technology to identify ISG15-binding proteins and discover Ring Finger Protein 213 (RNF213) as an ISG15 interactor and cellular sensor of ISGylated proteins. RN...

Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models.
https://doi.org/10.1038/s41467-021-26084-3 10.1172/JCI78167 10.1038/s41583-018-0006-3 10.1038/13810 10.1016/0092-8674(92)90610-O 10.1016/j.molcel.2010.01.030 10.1126/science.abd5581 10.1038/85906 10.1038/85899 10.1038/nn.3434 10.1038/nature14319 10.1016/j.molcel.2019.10.032 10.1126/science.1153252 10.1038/nrm3525 10.1016/j.molcel.2019.09.017 10.1073/pnas.0507856102 10.1371/journal.pgen.1006129 10.1038/ng.841 10.1016/j.neuron.2018.09.026 10.1101/gad.182477.111 10.7554/eLife.45418 10.1016/j.neuron.2018.01.020 10.1093/emboj/cdg089 10.1074/jbc.M511556200 10.1101/gad.1703108 10.1038/nsmb.1545 10.1016/j.cell.2016.03.040 10.1016/j.cell.2017.06.022 10.1016/j.jmb.2018.05.014 10.1016/j.celrep.2014.02.005 10.1016/j.molcel.2007.12.028 10.1172/JCI90967 10.1016/j.cell.2017.10.024 10.1038/nrm3920 10.1074/jbc.M700855200 10.1038/nm.4406 10.1007/s10038-004-0145-4 10.1126/science.1138659 10.1371/journal.pgen.1005226 10.1371/journal.pone.0073323 10.1038/nature10110 10.1038/nn.4536 10.1016/j.neuron.2019.03.032 10.1038/nrm.2017.7 10.1126/science.aaf4382 10.1007/s11427-020-1702-x 10.1038/s41422-020-0288-7 10.1038/s41421-020-0172-0 10.1038/s41586-020-2574-4 10.1146/annurev-biochem-060614-034242 10.1038/cr.2013.110 10.1038/ncomms15134 10.1016/j.cell.2017.06.037 10.1093/bioinformatics/btu170 10.1093/nar/gky955 10.1038/nmeth.3317 10.1093/bioinformatics/btu638 10.1073/pnas.1419161111 10.1016/j.ajhg.2020.07.005 10.1016/j.ymeth.2019.10.003 10.1016/j.ymeth.2019.11.008 10.1093/bioinformatics/btx330 10.1093/bioinformatics/bts635 10.1101/gr.209601.116 10.1002/0471250953.bi1112s47 10.1186/s13059-017-1364-2 10.1016/j.cell.2012.12.023 10.1038/nmeth.1923 10.1093/bioinformatics/btp352 10.1186/gb-2008-9-9-r137 10.1093/bioinformatics/btv145
Nature Communications; Jiang Y, Fu X et. al.

Oct 3rd, 2021 - Rett syndrome (RTT) is a severe neurological disorder and a leading cause of intellectual disability in young females. RTT is mainly caused by mutations found in the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2). Despite extensive studies, the molecular mechanism underlying RTT pathogenesis is still poorly understood. Here, we report MeCP2 as a key subunit of a higher-order multiu...

Effects of Hypoxia on Proliferation and Apoptosis of Osteosarcoma Cells.
https://doi.org/10.21873/anticanres.15293
Anticancer Research; Yang SY, Garcia E et. al.

Oct 2nd, 2021 - Hypoxia can happen during solid tumor growth including osteosarcoma. This study investigated the relationship of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) on osteosarcoma cell growth and apoptosis under hypoxic conditions. Human osteosarcoma cells were cultured under normal or hypoxic conditions. Inhibitors of HIF-1α and VEGF were applied to the cells se...

Heat Shock Protein 105 as an Immunotherapeutic Target for Patients With Cervical Cancer.
https://doi.org/10.21873/anticanres.15289
Anticancer Research; Nosaka K, Suzuki S et. al.

Oct 2nd, 2021 - Heat shock protein 105 (HSP105) is overexpressed in various cancers, but not in normal tissues. We investigated the expression levels of HSP105 in cervical cancer and the efficacy of immunotherapy targeting HSP105. Previously, we established human leukocyte antigen-A*02:01 (HLA-A2) restricted HSP105 peptide-specific cytotoxic T lymphocyte (CTL) clones from a colorectal cancer patient vaccinated...

REIC/Dkk-3 Gene Therapy Induces Immunogenic Cell Death in a Mouse Model of Malignant Me...
https://doi.org/10.21873/anticanres.15298
Anticancer Research; Araki K, Yamamuro N et. al.

Oct 2nd, 2021 - The adenovirus vector- carrying reduced expression in immortalized cell (REIC) gene (Ad-REIC) increases endoplasmic reticulum stress chaperone GRP78/BiP expression and induces the JNK-mediated apoptotic pathway. We aimed to determine whether Ad-REIC-induced apoptotic cell death can trigger immunogenic cell death (ICD). We examined the emission of damage-associated molecular patterns in vitro an...

Synergistic Antitumor Effect of Taxanes and CDK4/6 Inhibitor in Lung Cancer Cells and M...
https://doi.org/10.21873/anticanres.15296
Anticancer Research; Son KH, Kim MY et. al.

Oct 2nd, 2021 - LY2835219 (LY), a novel CDK4/6 inhibitor, prevents cell proliferation through G1 arrest. Docetaxel (DTX) and paclitaxel (PTX) are cytotoxic drugs targeting tubulin-mediated apoptotic cell death via G2/M arrest. We evaluated the antitumor effects of DTX/PTX and LY individually and in combination in lung adenocarcinoma cells with or without KRAS mutations and xenograft mice harboring KRAS mutatio...

Ethylmalonic Encephalopathy 1 Protein Is Increased in Colorectal Adenocarcinoma.
https://doi.org/10.21873/anticanres.15286
Anticancer Research; Ozluk E, Coppola D et. al.

Oct 2nd, 2021 - Ethylmalonic encephalopathy 1 protein (ETHE1) plays an important role in sulfide catabolism and polysulfide formation. As sulfides and polysulfides have recently been identified as playing important roles in cancer, we hypothesized that ETHE1 expression would be increased in colon cancer. We used tissue microarray analysis to compare ETHE1 expression in benign colonic epithelium compared to col...