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About 331,308 results

Comparative transcription profiling of mRNA and lncRNA in pulmonary arterial hypertensi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887911
BMC Pulmonary Medicine; Hou C, Xie L et. al.

Feb 1st, 2023 - To investigate mRNA and long non-coding RNA (lncRNA) expression profiles in monocrotaline (MCT)- mice. Lung tissues (Control-Vehicle, MCT-Vehicle, and MCT-C75) were examined by high-throughput sequencing (HTS). Aberrantly expressed mRNAs and lncRNAs were analyzed by bioinformatics. Cell proliferation and cell cycle analysis were performed to detect the potential protective effects of C75, an in...

ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/E...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885678
Journal of Translational Medicine; Xu J, Wang Y et. al.

Feb 1st, 2023 - Clear cell renal cell carcinoma (ccRCC) is a major worldwide health problem due to its high prevalence and mortality rate. A disintegrin and metalloproteinase 12 (ADAM12) is aberrantly expressed in various cancers and plays an important role in tumor progression. However, its explicit effect and molecular mechanism in ccRCC remain unclear. We investigated the dysregulation of ADAM12 in ccRCC th...

Cotargeting of BTK and MALT1 overcomes resistance to BTK inhibitors in mantle cell lymp...
https://doi.org/10.1172/JCI165694
The Journal of Clinical Investigation; Jiang VC, Liu Y et. al.

Feb 1st, 2023 - Bruton's tyrosine kinase (BTK) is a proven target in mantle cell lymphoma (MCL), an aggressive subtype of non-Hodgkin lymphoma. However, resistance to BTK inhibitors is a major clinical challenge. We here report that MALT1 is one of the top overexpressed genes in ibrutinib-resistant MCL cells, while expression of CARD11, which is upstream of MALT1, is decreased. MALT1 genetic knockout or inhibi...

NLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lup...
https://doi.org/10.1172/JCI157272
The Journal of Clinical Investigation; Tsao YP, Tseng FY et. al.

Feb 1st, 2023 - Signaling driven by nucleic acid sensors participates in interferonopathy-mediated autoimmune diseases. NLRP12, a pyrin-containing NLR protein, is a negative regulator of innate immune activation and type I interferon (IFN-I) production. Peripheral blood mononuclear cells (PBMCs) derived from systemic lupus erythematosus (SLE) patients expressed lower levels of NLRP12, with an inverse correlati...

TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrop...
https://doi.org/10.1073/pnas.2209967120
Proceedings of the National Academy of Sciences of the Un... Eguchi A, Gonzalez AFGS et. al.

Feb 1st, 2023 - Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease caused by the lack of dystrophin. Heart failure, driven by cardiomyocyte death, fibrosis, and the development of dilated cardiomyopathy, is the leading cause of death in DMD patients. Current treatments decrease the mechanical load on the heart but do not address the root cause of dilated cardiomyopathy: cardiomyocyte death. P...

Long Noncoding RNA IPW Is a Novel Diagnostic and Predictive Biomarker in Lung Adenocarc...
https://doi.org/10.1089/gtmb.2022.0173
Genetic Testing and Molecular Biomarkers; Liu Z, Jiang H et. al.

Feb 1st, 2023 - Background: Long non-coding RNAs (lncRNAs), as functional components of the human genome, are widely involved in cell proliferation, differentiation, apoptosis, migration and invasion by several types of cancer, including lung cancer. However, the role of lncRNA IPW in lung cancer has not been fully elucidated. The aim of the present study was to characterize the expression and clinical signifi...

Hyperuricemia exacerbates abdominal aortic aneurysm formation through the URAT1/ERK/MMP...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885634
BMC Cardiovascular Disorders; Wang JC, Tsai SH et. al.

Jan 31st, 2023 - Previous studies have revealed associations between hyperuricemia and microvascular diseases, but the association between hyperuricemia and abdominal aortic aneurysm (AAA) remains unclear. The aim of this study was to elucidate the pathogenesis and prove the relationship between AAA and hyperuricemia. A retrospective study was performed to validate the growth rates of AAA in humans with differe...

Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Sc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880028
Drug Design, Development and Therapy; Chlebowicz J, Akella R et. al.

Jan 31st, 2023 - WNK [with no lysine (K)] kinases are serine/threonine kinases associated with familial hyperkalemic hypertension (FHHt). WNKs are therapeutic targets for blood pressure regulation, stroke and several cancers including triple negative breast cancer and glioblastoma. Here, we searched for and characterized novel WNK kinase inhibitors. We used a ~210,000-compound library in a high-throughput scree...

2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcom...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887913
Molecular Medicine (Cambridge, Mass.); Jing D, Chen X et. al.

Jan 31st, 2023 - Osteosarcoma is a malignant bone tumor that usually affects adolescents aged 15-19 y. The DNA damage response (DDR) is significantly enhanced in osteosarcoma, impairing the effect of systemic chemotherapy. Targeting the DDR process was considered a feasible strategy benefitting osteosarcoma patients. However, the clinical application of DDR inhibitors is not impressive because of their side eff...

Pomegranate Peel Extract Sensitizes Hepatocellular Carcinoma Cells to Ionizing Radiatio...
https://doi.org/10.1177/15347354221151021
Integrative Cancer Therapies; Elbakry MMM, ElBakary NM et. al.

Jan 31st, 2023 - Tumor resistance is typically blamed for the failure of radiotherapy and chemotherapy to treat cancer in clinic patients. To improve the cytotoxicity of tumor cells using radiation in conjunction with specific tumor-selective cytotoxic drugs is crucial. Pomegranate has received overwhelmingly positive feedback as a highly nutritious food for enhancing health and treating a variety of ailments. ...

Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition vi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886945
Nature Communications; Morichaud Z, Trapani S et. al.

Jan 31st, 2023 - Self-assembly of macromolecules into higher-order symmetric structures is fundamental for the regulation of biological processes. Higher-order symmetric structure self-assembly by the gene expression machinery, such as bacterial DNA-dependent RNA polymerase (RNAP), has never been reported before. Here, we show that the stress-response σB factor from the human pathogen, Mycobacterium tuberculosi...

Differential Plasma Proteins Identified via iTRAQ-Based Analysis Serve as Diagnostic Ma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883097
Disease Markers; Chen X, Liao X et. al.

Jan 31st, 2023 - We aimed to identify differentially expressed proteins in the plasma of patients with pancreatic cancer and control subjects, which could serve as potential tumor biomarkers. Differentially expressed proteins were determined via isostatic labeling and absolute quantification (iTRAQ). Potential protein biomarkers were identified via enzyme-linked immunosorbent assay (ELISA) in 40 patients and 40...

A novel class of sulphonamides potently block malaria transmission by targeting a Plasm...
https://doi.org/10.1242/dmm.049950
Disease Models & Mechanisms; Yahiya S, Saunders CN et. al.

Jan 31st, 2023 - Phenotypic cell-based screens are critical tools for discovering candidate drugs for development, yet identification of the cellular target and mode of action of a candidate drug is often lacking. Using an imaging-based screen, we recently discovered an N-[(4-hydroxychroman-4-yl)methyl]-sulphonamide (N-4HCS) compound, DDD01035881, that blocks male gamete formation in the malaria parasite life c...

The prognostic value and immune correlation of IL18 expression and promoter methylation...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883904
Clinical Epigenetics; Wang X, Zhu W et. al.

Jan 29th, 2023 - Renal cell carcinoma (RCC) is not sensitive to immunotherapy and has poor prognosis. DNA methylation regulates gene expression, and its abnormal changes are related to many human diseases. Recently, DNA methylation has been found to participate in immune infiltration in various cancers. However, its pattern in RCC remains poorly understood. We found that IL18 was significantly over-expressed in...

Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883925
Molecular Neurodegeneration; Kisler K, Sagare AP et. al.

Jan 29th, 2023 - PICALM is one of the most significant susceptibility factors for Alzheimer's disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium. PICALM endothelial levels are reduced in AD brains. PICALM controls several steps in Aβ transcytosis across the blood-brain barrier (BBB). Its loss from brain endothelium in mice diminishes Aβ clearance at the BBB, which worsens Aβ patho...

Interleukin-38 suppresses abdominal aortic aneurysm formation in mice by regulating mac...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884112
Physiological Reports; Kurose S, Matsubara Y et. al.

Jan 29th, 2023 - Macrophages play crucial roles in abdominal aortic aneurysm (AAA) formation through the inflammatory response and extracellular matrix degradation; therefore, regulating macrophages may suppress AAA formation. Interleukin-38 (IL-38) is a member of the IL-1 family, which binds to IL-36 receptor (IL1RL2) and has an anti-inflammation effect. Because macrophages express IL1RL2, we hypothesized that...

Histone methyltransferase SETD1A interacts with notch and promotes notch transactivatio...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883963
BMC Cancer; Chai H, Pan C et. al.

Jan 29th, 2023 - High expression of SETD1A, a histone methyltransferase that specifically methylates H3K4, acted as a key oncogene in several human cancers. However, the function and underlying molecular mechanism of SETD1A in ovarian cancer (OV) remain markedly unknown. The expression of SETD1A in OV were detected by Western blot and analyzed online, and the prognosis of STED1A in OV were analyzed online. The ...

Exaggerated levels of some specific TLRs, cytokines and chemokines in Japanese encephal...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881527
Virology Journal; Shukla M, Garg A et. al.

Jan 29th, 2023 - Japanese encephalitis (JE) disease, a viral brain fever is caused by Japanese encephalitis virus (JEV). Despite the availability of effective vaccines against this deadly infection, JE is the leading cause of epidemic viral encephalitis in children in South-east Asia. There is no treatment available for the JE disease which might be due to incomplete understanding of the pathogenesis of JE viru...

The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883885
Journal of Translational Medicine; Shen X, Zhi F et. al.

Jan 29th, 2023 - Arsenic trioxide (ATO) is the first-line therapeutic drug for acute promyelocytic leukemia. However, the cardiotoxicity of ATO limits its clinical application. This study aims to explore the long noncoding RNA (lncRNA) involved molecular mechanism in ATO-induced cardiotoxicity and to identify available prevention strategies. ATO was administered to mice or primary cultured mouse cardiomyocytes....

TRMT6 promotes hepatocellular carcinoma progression through the PI3K/AKT signaling path...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881333
European Journal of Medical Research; Ye Y, Liu M et. al.

Jan 29th, 2023 - Hepatocellular carcinoma is one of the most common and deadly cancers. The aim of this study was to elucidate the role of tRNA methyltransferase 6 (TRMT6) during HCC progression. The role of TRMT6 in the progression and prognosis of HCC was confirmed by analysis of online databases and clinical human samples. The effects of up-regulation or down-regulation of TRMT6 on HCC cell proliferation and...