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About 230,045 results

CircCDC45 promotes the malignant progression of glioblastoma by modulating the miR-485-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501713
BMC Cancer; Liu R, Dai W et. al.

Oct 11th, 2021 - Glioblastoma (GBM) is characterized by progressive growth and metastasis. Numerous studies claim that the deregulation of circular RNAs (circRNAs) is associated with cancer progression. However, the role of circRNAs in GBM is largely limited. The purpose of this study was to investigate the functions of circCDC45 in GBM and provide a feasible functional mechanism to support its role. The expres...

Comparison of long-term outcome according to involved aganglionic segments of total col...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500650
Medicine Youn JK, Yang HB et. al.

Oct 9th, 2021 - Total colonic aganglionosis (TCA) is a rare form of Hirschsprung disease, with more severe symptoms than rectosigmoid Hirschsprung disease. We aimed to evaluate the surgical outcomes according to the involved segments of TCA.Patients with aganglionosis extending from the anus to at least the ileocecal valve were included. The medical records of 33 TCA patients from 1981 to 2014 were reviewed. T...

The impact of venous resection in pancreatoduodectomy: A systematic review and meta-ana...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500612
Medicine Filho JELP, Tustumi F et. al.

Oct 9th, 2021 - Vein resection pancreatoduodenectomy (VRPD) may be performed in selected pancreatic cancer patients. However, the main risks and benefits related to VRPD remain controversial. This review aimed to evaluate the risks and survival benefits that the VRPD may add when compared with standard pancreatoduodenectomy (PD). A systematic review and meta-analysis of studies comparing VRPD and PD were perfo...

Total lesion glycolysis as a predictor of clinical T3-4a laryngeal cancer with laryngec...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500594
Medicine Suzuki H, Tamaki T et. al.

Oct 9th, 2021 - The purpose of the present study is to investigate whether the 18F-fluorodeoxyglucose (18F-FDG) uptake parameter is related to survival outcomes for patients with clinical T3-T4a laryngeal cancer with various definitive treatments including total laryngectomy (TL). Parameters of 18F-FDG uptake in the primary tumors of 46 cases which were assessed by positron emission tomography with computed to...

Risk of herpes zoster associated with biological therapies for psoriasis and psoriatic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500657
Medicine Zou A, Chen Y et. al.

Oct 9th, 2021 - Biological therapy is effective for the treatment of psoriasis and psoriatic arthritis; however, adverse effects related to immunosuppression, such as viral infections, have been reported. Amongst these infections, herpes zoster (HZ) is common. To evaluate the risk of HZ in psoriasis and psoriatic arthritis patients treated with biological therapy. A comprehensive literature search of PubMed, E...

Adaptations to Protect Sideline Providers as They Respond to Sudden Cardiac Arrest Duri...
https://doi.org/10.1249/JSR.0000000000000892
Current Sports Medicine Reports; Colbenson K, Asplund CA et. al.

Oct 9th, 2021 - The 2019 severe acute respiratory syndrome coronavirus 2 has dramatically changed the sports landscape, compelling sports medical providers to adapt to evolving scientific discoveries and adopt ever-changing guidelines that protect our athletes, ourselves, and our staff. To best serve our athletes, providers need to be proactive and anticipate potential complications in providing care for athle...

Evaluation of Respiratory Emissions During Labor and Delivery: Potential Implications f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462302
Obstetrics and Gynecology; Mok T, Harris E et. al.

Oct 9th, 2021 - To characterize respiratory emissions produced during labor and vaginal delivery vis-à-vis the potential for transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Observational study of three women who tested negative for SARS-CoV-2 and had uncomplicated vaginal deliveries. Using background-oriented schlieren imaging, we evaluated the propagation of respiratory emissions...

Multicomponent Strategies to Prevent SARS-CoV-2 Transmission - Nine Overnight Youth Sum...
https://doi.org/10.15585/mmwr.mm7040e1
MMWR. Morbidity and Mortality Weekly Report; Van Naarden Braun K, Drexler M et. al.

Oct 8th, 2021 - Most U.S. overnight youth camps did not operate during the summer of 2020 because of the COVID-19 pandemic* (1). Several that did operate demonstrated that multiple prevention strategies, including pre- and postarrival testing for SARS-CoV-2, the virus that causes COVID-19, masking, and physical distancing helped prevent the introduction and spread of COVID-19; in contrast, camps that relaxed p...

Eosinophilic Esophagitis: A Review.
https://doi.org/10.1001/jama.2021.14920
JAMA Muir A, Falk GW

Oct 6th, 2021 - Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disease of the esophagus that affects an estimated 34.4/100 000 people in Europe and North America. EoE affects both children and adults, and causes dysphagia, food impaction of the esophagus, and esophageal strictures. EoE is defined by symptoms of esophageal dysfunction, such as vomiting, dysphagia, or feeding difficulti...

Identification and validation of a hypoxia-related prognostic signature in clear cell r...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483867
Medicine Li Z, Du G et. al.

Oct 2nd, 2021 - Increasing evidence has shown that hypoxia is closely related to the development, progression, and prognosis of clear cell renal cell carcinoma (ccRCC). Nevertheless, reliable prognostic signatures based on hypoxia have not been well-established. This study aimed to establish a hypoxia-related prognostic signature and construct an optimized nomogram for patients with ccRCC.We accessed hallmark ...

Systemic lupus erythematosus presenting as hyponatremia-associated rhabdomyolysis: A ca...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483824
Medicine Lee IH, Cho S et. al.

Oct 2nd, 2021 - Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple organs and causes various clinical manifestations. Cases of rhabdomyolysis as the initial presentation of SLE are rare, and there are no reported cases of SLE presenting hyponatremia-associated rhabdomyolysis as the first manifestation. Herein, we report a case of SLE with lupus nephritis in a patient with acute ...

Intensity-modulated Radiotherapy in Patients With Aggressive Extranodal Non-Hodgkin Lym...
https://doi.org/10.21873/anticanres.15330
Anticancer Research; Eismann J, Elsayad K et. al.

Oct 2nd, 2021 - Image-guided intensity-modulated radiotherapy (IG-IMRT) is increasingly being used to treat patients with head and neck malignancies. This analysis compared conventional radiotherapy (CRT) and IMRT outcomes for head and neck aggressive extranodal non-Hodgkin lymphomas (EN-NHL). Forty-eight patients who underwent irradiation between 2005 and 2019 were identified. The median follow-up was 42 mont...

Clinical Significance of 18F-fluorodeoxyglucose and Glucose Transporter 1 mRNA in Clear...
https://doi.org/10.21873/anticanres.15336
Anticancer Research; Betsunoh H, Sakamoto S et. al.

Oct 2nd, 2021 - 18F-fluorodeoxyglucose (FDG) uptake measurement on positron emission tomography/computed tomography (PET/CT) is difficult in renal tumors because of the nearby renal parenchyma and urinary tract, which excrete FDG. We carefully examined the maximum standardized uptake value (SUVmax) on FDG-PET/CT and investigated the relationship between major glucose transporters in the kidney and clear cell r...

Chemoembolization for Hepatocellular Carcinoma in Patients With Inferior Vena Caval/Rig...
https://doi.org/10.21873/anticanres.15343
Anticancer Research; Kim M, Kim HC et. al.

Oct 2nd, 2021 - To clarify the clinical and radiological features of isolated tumor thrombi in the inferior vena cava (IVC)/right atrium in patients with hepatocellular carcinoma (HCC) without hepatic vein invasion. In this retrospective study, from January 2007 to December 2019, a total of 35,163 chemoembolization sessions were performed in 7,704 patients with HCC. Among them, 10 (0.13%) patients had tumor th...

Possible future waves of SARS-CoV-2 infection generated by variants of concern with a r...
https://doi.org/10.1038/s41467-021-25915-7 10.1016/S1473-3099(21)00202-4 10.1038/s41564-020-0770-5 10.1126/science.abg3055 10.1038/s41586-021-03426-1 10.1136/bmj.n579 10.2807/1560-7917.ES.2021.26.11.2100256 10.1056/NEJMoa2102214 10.1038/s41591-021-01318-5 10.1038/s41591-021-01413-7 10.2807/1560-7917.ES.2021.26.23.2100447 10.1126/science.abh2644 10.1073/pnas.252512799 10.1007/s00285-015-0873-4 10.3390/vaccines9060592 10.1073/pnas.2009911117 10.1016/j.cub.2020.06.031 10.1098/rsos.210530 10.1016/j.mbs.2008.02.009 10.1016/j.epidem.2019.100383 10.1186/s12916-015-0544-8 10.1016/S0140-6736(21)00675-9 10.1016/S0140-6736(21)00575-4 10.1126/science.abc2535 10.1371/journal.pmed.0050074 10.1371/journal.pcbi.1005697 10.1016/0021-9991(76)90041-3 10.1021/j100540a008 10.1016/S2214-109X(21)00043-7 10.1056/NEJMoa2103055
Nature Communications; Dyson L, Hill EM et. al.

Oct 2nd, 2021 - Viral reproduction of SARS-CoV-2 provides opportunities for the acquisition of advantageous mutations, altering viral transmissibility, disease severity, and/or allowing escape from natural or vaccine-derived immunity. We use three mathematical models: a parsimonious deterministic model with homogeneous mixing; an age-structured model; and a stochastic importation model to investigate the effec...

Symptom Outcomes of Cancer Patients With Clival Metastases Treated With Radiotherapy: A...
https://doi.org/10.21873/anticanres.15314
Anticancer Research; Sturgis R, Mack A et. al.

Oct 2nd, 2021 - To describe clinical features, radiotherapy (RT), and symptom outcomes in cancer patients with cranial nerve palsies associated with clival metastases. This is a retrospective review of patients with primary metastatic cancers who developed clival metastases and received RT (2000-2020). Of the 44 patients with primary cancers (manly breast, prostate and multiple myeloma cancers) and distal cliv...

A Posterior-Anterior Cephalometric Study of Skull Symmetry in Patients With Neurofibrom...
https://doi.org/10.21873/anticanres.15318
Anticancer Research; Friedrich RE, Christ G et. al.

Oct 2nd, 2021 - Neurofibromatosis type 1 (NF1) is a tumor predisposition syndrome. Bone findings make a significant contribution to the clinical diagnosis of NF1. It has been suggested that there are characteristic skeletal features of the NF1 patients' skull that cause a specific 'NF1 facies'. To test this thesis, skull examinations were carried out on NF1 patients. The posteroanterior (PA) cephalograms of 76...

Heat Shock Protein 105 as an Immunotherapeutic Target for Patients With Cervical Cancer.
https://doi.org/10.21873/anticanres.15289
Anticancer Research; Nosaka K, Suzuki S et. al.

Oct 2nd, 2021 - Heat shock protein 105 (HSP105) is overexpressed in various cancers, but not in normal tissues. We investigated the expression levels of HSP105 in cervical cancer and the efficacy of immunotherapy targeting HSP105. Previously, we established human leukocyte antigen-A*02:01 (HLA-A2) restricted HSP105 peptide-specific cytotoxic T lymphocyte (CTL) clones from a colorectal cancer patient vaccinated...

Impact of Inferior Mesenteric Artery Occlusion on the Calibre of Collateral Arteries of...
https://doi.org/10.21873/anticanres.15337
Anticancer Research; Iida T, Murono K et. al.

Oct 2nd, 2021 - The inferior mesenteric arteries (IMA) are occluded in some colorectal cancer patients. This study evaluated the impact of IMA occlusion on the calibre of collateral arteries. As an IMA obstruction model, 20 patients who underwent abdominal aortic aneurysm surgery, with ligated, excluded, or embolised IMA, were enrolled. Changes in the calibre of the left colic arteries (LCAs) and marginal arte...

Clinical validation of the Oswestry-Bristol Classification as part of a decision algori...
https://doi.org/10.1302/0301-620X.103B10.BJJ-2020-1984.R1
The Bone & Joint Journal; Sharma N, Rehmatullah N et. al.

Oct 1st, 2021 - The Oswestry-Bristol Classification (OBC) is an MRI-specific assessment tool to grade trochlear dysplasia. The aim of this study is to validate clinically the OBC by demonstrating its use in selecting treatments that are safe and effective. The OBC and the patellotrochlear index were used as part of the Oswestry Patellotrochlear Algorithm (OPTA) to guide the surgical treatment of patients with ...