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About 50,770 results

ABPA sans asthma: an entity to remember.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703309
BMJ Case Reports; Nair AA, Vimala LR et. al.

Nov 26th, 2022 - A male patient in his 20s presented with a cough and a small volume of haemoptysis that lasted a year. He had no other constitutional symptoms and a respiratory examination was suggestive of a consolidation. A chronic infection, such as tuberculosis, was suspected. The routine evaluation showed peripheral eosinophilia with raised serum total IgE. Sputum examination for tuberculosis was negative...

Omadacycline for management of Mycobacterium abscessus infections: a review of its effe...
https://doi.org/10.1186/s12879-022-07857-7
BMC Infectious Diseases; Rizzo AR, Moniri NH

Nov 25th, 2022 - The Mycobacterium abscessus complex (MABC) is a group of acid-fast, rapidly dividing non-tuberculous mycobacteria (NTM) that include a number of clinically important subspecies, including M. abscessus, M. bolletii, and M. massiliense. These organisms are prevalent in the environment and are primarily associated with human pulmonary or skin and skin structure infections (SSSI) but may cause more...

Host transcriptomic profiling of CD-1 outbred mice with severe clinical outcomes follow...
https://doi.org/10.1371/journal.pntd.0010459
PLoS Neglected Tropical Diseases; Thiriot J, Liang Y et. al.

Nov 24th, 2022 - Orientia tsutsugamushi is an obligately intracellular bacterium with endothelial tropism and can cause mild to lethal scrub typhus in humans. No vaccine is available for this reemerging and severely neglected infection. Previous scrub typhus studies have utilized inbred mice, yet such models have intrinsic limitations. Thus, the development of suitable mouse models that better mimic human disea...

Emergence and Evolutionary Response of Vibrio cholerae to Novel Bacteriophage, Democrat...
https://doi.org/10.3201/eid2812.220572
Emerging Infectious Diseases; Alam MT, Mavian C et. al.

Nov 24th, 2022 - Cholera causes substantial illness and death in Africa. We analyzed 24 toxigenic Vibrio cholerae O1 strains isolated in 2015-2017 from patients in the Great Lakes region of the Democratic Republic of the Congo. Strains originating in southern Asia appeared to be part of the T10 introduction event in eastern Africa. We identified 2 main strain lineages, most recently a lineage corresponding to s...

Taxonomic and functional profiling of Indian smokeless tobacco bacteriome uncovers seve...
https://doi.org/10.1007/s11274-022-03461-8
World Journal of Microbiology & Biotechnology; Vishwakarma A, Srivastava A et. al.

Nov 22nd, 2022 - Smokeless tobacco (ST) consumption keeps human oral health at high risk which is one of the major reasons for oral tumorigenesis. The chemical constituents of the ST products have been well discussed; however, the inhabitant microbial diversity of the ST products is less explored especially from south Asian regions. Therefore, the present investigation discusses the bacteriome-based analysis of...

Epidemiology and bacterial characteristics of invasive group B streptococcus disease: a...
https://doi.org/10.1017/S0950268822001534
Epidemiology and Infection; Takeuchi N, Chang B et. al.

Nov 22nd, 2022 - This is the first report on a population-based prospective study of invasive group B streptococcus (GBS) disease among children aged <15 years conducted over a period of 11 years in Japan. This study investigated the incidence and clinical manifestations of invasive GBS disease in children in Chiba Prefecture, Japan, and analysed the serotypes and drug susceptibility of GBS strains isolated dur...

Central Nervous System Mycobacterium Infection: Tuberculosis and Beyond.
https://doi.org/10.1016/j.nic.2022.07.006
Neuroimaging Clinics of North America; Park M, Gupta RK

Nov 21st, 2022 - Tuberculosis is a contagious infectious disease caused by Mycobacterium tuberculosis, and is the leading cause of death from a single infectious agent worldwide. Imaging plays an important role in the early diagnosis of central nervous system tuberculosis and may prevent unnecessary morbidity and mortality. This article presents an extensive review of pathogenesis, clinical symptoms, typical an...

Evaluation of three alternatives cost-effective culture media for Mycobacterium tubercu...
https://doi.org/10.1016/j.tube.2022.102273
Tuberculosis (Edinburgh, Scotland); Rodriguez J, Alcántara R et. al.

Nov 21st, 2022 - Tuberculosis phenotypic detection assays are commonly used in low-resource countries. Therefore, reliable detection methods are crucial for early diagnosis and treatment. The microscopic observation drug susceptibility (MODS) assay is a culture-based test to detect Mycobacterium tuberculosis and characterize drug resistance in 7-10 days directly from sputum. The use of MODS is limited by the av...

The systemic oral health connection: Biofilms.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678577
Medicine Kurtzman GM, Horowitz RA et. al.

Nov 20th, 2022 - Frequently, periodontal health and it's associated oral biofilm has not been addressed in those patients who have systemic health issues, especially those who are not responding to medical treatment via their physician. Oral biofilm may be present in the periodontal sulcus in the absence of clinical disease of periodontal disease (bleeding on probing, gingival inflammation) and periodontal reac...

Value of sputum Gram stain, sputum culture, and bronchoalveolar lavage fluid Gram stain...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675245
BMC Pulmonary Medicine; Zhang R, Wu Y et. al.

Nov 20th, 2022 - Currently, the microbial etiology of community-acquired pneumonia in children remains challenging. While Gram stain and sputum culture are commonly used to detect bacterial pathogens, it is unclear whether these approaches can predict single pathogen from bronchoalveolar lavage fluid (BALF) culture. A retrospective study involving 287 children hospitalized for pneumonia was conducted. Sputum sp...

Aerococcus urinae, a rare cause of aortic root abscess: a case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670598
Journal of Medical Case Reports; Tiong CW, Bartolo C et. al.

Nov 19th, 2022 - Aerococcus urinae is a bacterium of emerging clinical interest that most commonly causes urinary tract infections (UTI) but can also result in invasive infections. It is a catalase-negative, alpha-haemolytic gram-positive coccus that grows in clusters or tetrads and usually causes urinary tract infections. While rare, infective endocarditis must be considered when A. urinae is isolated in blood...

Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associa...
https://doi.org/10.1016/S2214-109X(22)00450-8
The Lancet. Global Health; Lawrence DS, Muthoga C et. al.

Nov 19th, 2022 - HIV-associated cryptococcal meningitis is a leading cause of AIDS-related mortality. The AMBITION-cm trial showed that a regimen based on a single high dose of liposomal amphotericin B deoxycholate (AmBisome group) was non-inferior to the WHO-recommended treatment of seven daily doses of amphotericin B deoxycholate (control group) and was associated with fewer adverse events. We present a five-...

Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684076
Nature Galeano Niño JL, Wu H et. al.

Nov 18th, 2022 - The tumour-associated microbiota is an intrinsic component of the tumour microenvironment across human cancer types1,2. Intratumoral host-microbiota studies have so far largely relied on bulk tissue analysis1-3, which obscures the spatial distribution and localized effect of the microbiota within tumours. Here, by applying in situ spatial-profiling technologies4 and single-cell RNA sequencing5 ...

Atypical involvement of the thyro-linguo-facial vein in Lemierre syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667992
BMJ Case Reports; Constans S, Bosshard T et. al.

Nov 16th, 2022 - Fusobacterium necrophorum is a Gram-negative anaerobic bacterium that can lead to severe infection in young patients even without immunodeficiency. Due to the length of time for isolation and speciation of this Gram-negative bacillus (typically 5-8 days), and its potential mortality, broad-spectrum antibiotic therapy should be started without delay. With a cervical thrombosis, even on an unusua...

Infective endocarditis: association between origin of causing bacteria and findings dur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664784
BMC Oral Health; Thoresen T, Jordal S et. al.

Nov 16th, 2022 - Oral streptococci represent the causing microorganism for infective endocarditis (IE) in many patients. The impact of oral infections is questioned, and it has been suggested that bacteraemia due to daily routines may play a bigger part in the aetiology of IE. The aim of this study was to examine the association between oral health and infective endocarditis caused by oral bacteria in compariso...

Human Dectin-1 deficiency impairs macrophage-mediated defense against phaeohyphomycosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663159
The Journal of Clinical Investigation; Drummond RA, Desai JV et. al.

Nov 16th, 2022 - Subcutaneous phaeohyphomycosis typically affects immunocompetent individuals following traumatic inoculation. Severe or disseminated infection can occur in CARD9 deficiency or after transplantation, but the mechanisms protecting against phaeohyphomycosis remain unclear. We evaluated a patient with progressive, refractory Corynespora cassiicola phaeohyphomycosis and found that he carried biallel...

An overview of micafungin as a treatment option for invasive candidiasis in pediatric p...
https://doi.org/10.1080/14656566.2022.2147824
Expert Opinion on Pharmacotherapy; Bassetti M, Giacobbe DR et. al.

Nov 15th, 2022 - Invasive candidiasis remains a leading cause of morbidity and mortality in various categories of patients at risk. Structure and mechanism of action, pharmacokinetics and pharmacodynamics, clinical studies, safety, and regulatory status of micafungin are explored in the present review, focusing on pediatric patients younger than 4 months old. Although limited, the available data on the efficacy...

Inhaled anti-pseudomonal antibiotics for long-term therapy in cystic fibrosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662285
The Cochrane Database of Systematic Reviews; Smith S, Rowbotham NJ

Nov 15th, 2022 - Inhaled antibiotics are commonly used to treat persistent airway infection with Pseudomonas aeruginosa that contributes to lung damage in people with cystic fibrosis. Current guidelines recommend inhaled tobramycin for individuals with cystic fibrosis and persistent Pseudomonas aeruginosa infection who are aged six years or older. The aim is to reduce bacterial load in the lungs so as to reduce...

Bovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology duri...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683594
PLoS Neglected Tropical Diseases; Lakin HA, Tavalire H et. al.

Nov 12th, 2022 - Bovine tuberculosis (BTB) is a zoonotic disease of global importance endemic in African buffalo (Syncerus caffer) in sub-Saharan Africa. Zoonotic tuberculosis is a disease of global importance, accounting for over 12,000 deaths annually. Cattle affected with BTB have been proposed as a model for the study of human tuberculosis, more closely resembling the localization and progression of lesions...

Infective endocarditis in solid organ transplant: a review.
https://doi.org/10.1097/MOT.0000000000000993
Current Opinion in Organ Transplantation; Suarez JF, Subramanian AK

Nov 11th, 2022 - Infective endocarditis remains an uncommon disease with significant morbidity and mortality. In the last two decades, progress has been made describing the unique aspects of infective endocarditis in solid organ transplant (SOT) recipients. Incidence of infective endocarditis in SOT is higher when compared with the general population. End-stage organ dysfunction, diabetes mellitus, older age, a...