×
About 49,535 results

The obligate intracellular bacterium Orientia tsutsugamushi differentiates into a devel...
https://doi.org/10.1038/s41467-022-31176-9 10.1371/journal.pntd.0003971 10.3390/tropicalmed3010008 10.1128/iai.30.1.231-243.1980 10.1086/589284 10.1128/IAI.01239-10 10.1371/journal.pntd.0003585 10.1128/IAI.01620-05 10.1016/j.micpath.2003.12.005 10.1128/IAI.01316-09 10.1371/journal.pntd.0004009 10.1111/mmi.13709 10.1155/2008/623145 10.1016/j.mimet.2019.105812 10.1128/iai.50.3.603-609.1985 10.1038/nrmicro2318 10.1038/nrmicro.2016.30 10.1111/mmi.13880 10.1038/ncomms4578 10.1371/journal.pntd.0006566 10.1038/s41467-020-17094-8 10.1146/annurev-genet-120215-035235 10.1016/j.cell.2016.09.023 10.1364/OE.26.008049 10.1126/science.1153529 10.1364/OE.22.015982 10.1093/nar/gkw1080
Nature Communications; Atwal S, Wongsantichon J et. al.

Jun 24th, 2022 - Orientia tsutsugamushi (Ot) is an obligate intracellular bacterium in the family Rickettsiaceae that causes scrub typhus, a severe mite-borne human disease. Its mechanism of cell exit is unusual amongst Rickettsiaceae, as Ot buds off the surface of infected cells enveloped in plasma membrane. Here, we show that Ot bacteria that have budded out of host cells are in a distinct developmental stage...

The thematic role of extracellular loop of VraG in activation of the membrane sensor Gr...
https://doi.org/10.1371/journal.pone.0270393
PloS One; Cho J, Rigby WFC et. al.

Jun 24th, 2022 - Patients with cystic fibrosis (CF) often suffer recurrent bronchial bacterial infections that lead to deterioration of lung function over time. The infections in CF patients are often due to S. aureus and P. aeruginosa that colonize the airways. Significantly, methicillin-resistant S. aureus (MRSA) makes it challenging for treatment in CF patients due to its feature of multiple antibiotic resis...

Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: ...
https://doi.org/10.1136/bmjopen-2021-057957
BMJ Open; Lokida D, Farida H et. al.

Jun 22nd, 2022 - To identify aetiologies of childhood community-acquired pneumonia (CAP) based on a comprehensive diagnostic approach. 'Partnerships for Enhanced Engagement in Research-Pneumonia in Paediatrics (PEER-PePPeS)' study was an observational prospective cohort study conducted from July 2017 to September 2019. Government referral teaching hospitals and satellite sites in three cities in Indonesia: Sema...

Identification of Helicobacter pylori-related gastric cancer risk using serological gas...
https://doi.org/10.1186/s12876-022-02381-z 10.3322/caac.21660 10.1002/ijc.28999 10.1056/NEJMoa001999 10.1371/journal.pone.0079088 10.1053/j.gastro.2017.01.029 10.1007/s12664-013-0378-2 10.1111/cas.12829 10.1111/j.1443-1661.2009.00839.x 10.1080/00365520601097351 10.1111/j.1443-9573.2007.00278.x 10.1007/s10120-006-0397-0 10.1093/aje/kwj088 10.1258/0969141041732184 10.1023/B:DDAS.0000030091.92379.91 10.2183/pjab.87.405 10.2188/jea.JE20150258 10.5301/JBM.2010.6087 10.1136/gut.2004.055400 10.1111/hel.12101 10.1159/000477239 10.1155/2017/1286198 10.1055/s-0028-1098086 10.1111/j.1523-5378.2011.00889.x 10.1097/PAS.0b013e3181d94d53 10.1055/a-0854-3818
BMC Gastroenterology; Nagasaki N, Ito M et. al.

Jun 21st, 2022 - Gastric cancer remains a severe public health problem worldwide, particularly in Japan. Recent studies have demonstrated that serum markers are beneficial for risk stratification in gastric cancer development. We aimed to evaluate the usefulness of serum markers either alone or in combination (serum markers plus endoscopy) for effective risk stratification of gastric cancer development. We enro...

Imaging findings of vertebral osteomyelitis caused by nontuberculous mycobacterial orga...
https://doi.org/10.1097/MD.0000000000029395 10.1136/bcr-2013-009597
Medicine Yu XJ, Lin YD et. al.

Jun 18th, 2022 - Prompt diagnosis of nontuberculous Mycobacterial (NTM) vertebral osteomyelitis is challenging, yet necessary to prevent serious morbidity and mortality. Here, we report 3 cases of vertebral osteomyelitis caused by NTM with imaging findings. Case 1, a 58-year-old male patient, was admitted to our hospital because of the presence of a pulmonary mass for 6 months with cough and chest pain.Case 2, ...

Ceftazidime-avibactam and intrapleural amikacin therapy for extensively drug-resistant ...
https://doi.org/10.1097/MD.0000000000029467
Medicine Chen TT, Chen SM et. al.

Jun 18th, 2022 - Thoracic empyema and concomitant bronchopleural fistula are serious complications of pneumonia. The treatment of empyema caused by extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) has become increasingly challenging. A 57-year-old woman with controlled schizophrenia developed hospital-associated bacterial pneumonia secondary to P. aeruginosa on day 13 of hospitalization for brain meni...

Bacteroides fragilis Bacteremia Complicated by Spondylodiscitis, Spinal Epidural Absces...
https://doi.org/10.12659/AJCR.936179
The American Journal of Case Reports; Papaetis GS, Petridis TA et. al.

Jun 17th, 2022 - BACKGROUND Pyogenic spondylitis comprises several clinical entities, including native vertebral osteomyelitis, septic discitis, pyogenic spondylodiscitis, and epidural abscess. The lumbar spine is most often infected, followed by the thoracic and cervical areas. It mainly develops (i) after spine surgery; (ii) from history of blunt trauma to the spinal column; (iii) from infections in adjacent ...

Optimising Xpert-Ultra and culture testing to reliably measure tuberculosis prevalence ...
https://doi.org/10.1136/bmjopen-2021-058195
BMJ Open; Floyd S, Klinkenberg E et. al.

Jun 17th, 2022 - Prevalence surveys remain the best way to assess the national tuberculosis (TB) burden in many countries. Challenges with using culture (the reference standard) for TB diagnosis in prevalence surveys have led to increasing use of molecular tests (Xpert assays), but discordance between these two tests has created problems for deciding which individuals have TB. We aimed to design an accurate dia...

A rare case of melioidosis presenting as myositis in Sri Lanka.
https://doi.org/10.1186/s12879-022-07515-y 10.1186/s13256-019-2321-3 10.1371/journal.pntd.0000900 10.1177/1535370215583801 10.3390/tropicalmed3010022 10.1128/CMR.18.2.383-416.2005 10.1086/509810 10.31128/AJGP-04-18-4558 10.1016/S0140-6736(03)13374-0
BMC Infectious Diseases; Vithana SMP, Chathuranga LS et. al.

Jun 16th, 2022 - Melioidosis caused by Burkholderia pseudomallei is an emerging infection in Sri Lanka with a high case fatality rate. The disease usually manifests as pneumonia, however multisystem involvement is common. Myositis is an extremely rare occurrence and this is the only documented case where the initial presentation of melioidosis has been myositis and later complicated to myonecrosis. A 45-year-ol...

Multiplex real-time PCR using SYBR Green: Unspecific intercalating dye to detect antimi...
https://doi.org/10.1371/journal.pone.0269895
PloS One; Souza MB, Cergole-Novella MC et. al.

Jun 15th, 2022 - Meningitis caused by Streptococcus pneumoniae is still a disease of great impact on Public health, which requires immediate diagnosis and treatment. However, the culture of clinical specimens is often negative and antibiotic susceptibility testing (AST) must be performed with isolated strains. Multiplex real-time polymerase chain reaction (qPCR) has high sensitivity and specificity, produces fa...

The oral microbiome, pancreatic cancer and human diversity in the age of precision medi...
https://doi.org/10.1186/s40168-022-01262-7 10.14740/wjon1166 10.5114/aoms.2020.94845 10.1016/j.ijsu.2015.06.050 10.1016/j.bpg.2005.10.001 10.1111/odi.12509 10.4103/jomfp.JOMFP 10.3390/s120302519 10.1186/1471-2180-9-259 10.1128/mSphere.00451-20 10.1113/JP272427 10.1038/s41598-018-30397-7 10.1177/0022034511418973 10.1007/s00248-016-0854-1 10.3390/ijms20246267 10.1016/j.chom.2011.09.008 10.33073/pjm-2014-018 10.1016/j.biopha.2016.09.082 10.1016/j.chom.2010.03.004 10.1016/j.coi.2011.07.010 10.3390/microorganisms7010020 10.3389/fimmu.2020.591088 10.1016/j.siny.2016.05.002 10.1007/s00203-018-1505-3 10.1097/PPO.0000000000000287 10.1097/PPO.0000000000000046 10.3390/cancers12020329 10.1016/j.pan.2012.06.002 10.1093/ajcn/78.1.176 10.1002/ijc.29710 10.1093/jnci/djk021 10.1097/MPA.0000000000000419 10.1158/1055-9965.EPI-18-1053 10.1038/s41575-019-0242-7 10.1136/gutjnl-2016-312580 10.1136/gutjnl-2012-303006 10.1002/cam4.2660 10.1136/gutjnl-2011-300784 10.1158/1538-7445.AM2013-101 10.3748/wjg.v26.i48.7679 10.1007/s10552-017-0933-8 10.1111/omi.12086 10.1128/JCM.39.10.3520-3523 10.1080/20002297.2017.1368848 10.1101/gad.228452.113 10.1038/sj.embor.7400908 10.1126/science.1080857 10.1186/s12864-017-4008-8 10.1016/j.chom.2017.08.013 10.1038/s41598-020-64747-1 10.1002/cam4.1277 10.1002/cam4.3042 10.1089/heq.2019.0057 10.1371/journal.pone.0077287 10.1128/mSystems.00639-19 10.1902/jop.1993.64.4.292 10.1902/jop.2002.73.3.283 10.1016/j.imlet.2019.12.004 10.1371/journal.pbio.3000825 10.1038/s41591-019-0465-8 10.1177/1933719113488838 10.1073/pnas.1002611107 10.1038/nature11450 10.1038/nature15367 10.1186/1475-2891-8-49 10.1002/ijc.31941 10.1016/j.tim.2016.08.001 10.1038/424374a 10.3322/canjclin.54.2.78 10.1001/jamasurg.2015.4239 10.1016/j.annepidem.2019.03.006 10.4103/1735-3327.280894 10.1200/JCO.2016.71.2026 10.1007/s00423-007-0266-2 10.1186/s40168-016-0226-6 10.1289/ehp.0901201 10.1016/j.jaut.2009.12.003 10.1007/s00011-008-8078-6 10.1902/jop.1975.46.2.82 10.1378/chest.100.3.628 10.1038/ismej.2016.37 10.3390/ijerph17010256 10.1128/IAI.05371-11 10.5430/jer.v2n2p92 10.1158/1940-6207.CAPR-19-0459 10.1158/1078-0432.CCR-18-3042 10.1183/09031936.00134014 10.1038/s41598-020-59016-0 10.1371/journal.pone.0189374 10.1038/s41598-020-62195-5 10.1128/mSystems.00630-19 10.1038/s41598-017-18677-0 10.1007/s11357-019-00098-8 10.1111/prd.12136 10.3390/biomedicines8060178 10.1016/j.pharmthera.2016.06.008 10.1038/labinvest.2015.117 10.1158/0008-5472.CAN-16-1765 10.1186/s12943-019-1008-0 10.1158/1055-9965.EPI-18-0542 10.1080/20002297.2021.1887680 10.1038/s41368-018-0043-9 10.1016/j.cell.2019.07.008 10.5830/CVJA-2012-016 10.1136/gut.2004.043059 10.18632/oncotarget.3109 10.1038/s41598-019-46634-6 10.1126/science.aah5043 10.1093/carcin/bgy073 10.1038/s41598-017-06789-6 10.1007/978-3-0348-0837-8_6 10.2330/joralbiosci.53.233 10.12998/wjcc.v7.i7.819 10.1158/2159-8290.CD-17-1134 10.1007/s40496-017-0121-7 10.4251/wjgo.v8.i4.380 10.1016/j.ajpath.2018.09.013 10.1038/sj.bdj.2016.865
Microbiome Herremans KM, Riner AN et. al.

Jun 15th, 2022 - Pancreatic cancer is a deadly disease with limited diagnostic and treatment options. Not all populations are affected equally, as disparities exist in pancreatic cancer prevalence, treatment and outcomes. Recently, next-generation sequencing has facilitated a more comprehensive analysis of the human oral microbiome creating opportunity for its application in precision medicine. Oral microbial s...

Gut microbiota in mucosa and feces of newly diagnosed, treatment-naïve adult inflammato...
https://doi.org/10.1080/19490976.2022.2083419
Gut Microbes; Čipčić Paljetak H, Barešić A et. al.

Jun 14th, 2022 - The knowledge on how gut microbes contribute to the inflammatory bowel disease (IBD) at the onset of disease is still scarce. We compared gut microbiota in newly diagnosed, treatment-naïve adult IBD (Crohn's disease (CD) and ulcerative colitis (UC)) to irritable bowel syndrome (IBS) patients and healthy group. Mucosal and fecal microbiota of 49 patients (13 UC, 10 CD, and 26 IBS) before treatme...

Safety and efficacy of fecal microbiota transplantation for treatment of systemic lupus...
https://doi.org/10.1016/j.jaut.2022.102844
Journal of Autoimmunity; Huang C, Yi P et. al.

Jun 12th, 2022 - Gut microbiota dysbiosis is involved in the development of systemic lupus erythematosus (SLE). The safety and efficacy of fecal microbiota transplantation (FMT) for the treatment of SLE patients has not been explored. In this 12-week, single-arm pilot clinical trial of oral encapsulated fecal microbiome from healthy donors to patients with active SLE, we aimed to evaluate the safety and efficac...

Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic ...
https://doi.org/10.1038/s41467-022-30661-5 10.1093/femsyr/fov081 10.1186/s40168-017-0373-4 10.1016/j.mib.2020.05.006 10.1038/s41591-019-0709-7 10.1016/j.jhin.2009.02.009 10.1186/s13613-020-00755-8 10.1371/journal.ppat.0040035 10.1038/s41586-021-03722-w 10.1093/cid/ciw038 10.1111/cmi.12657 10.1136/adc.69.5_Spec_No.483 10.1093/femsre/fuaa060 10.1093/femsyr/foz008 10.1038/s41598-019-44579-4 10.1371/journal.pone.0131220 10.1038/s41598-019-39625-0 10.1111/1751-7915.12799 10.1007/s12223-017-0569-9 10.1016/j.micpath.2018.02.019 10.1111/jam.13289 10.1038/s41467-021-26390-w 10.1007/s00253-016-7527-3 10.1007/s11046-018-0259-4 10.1016/j.ejogrb.2018.07.005 10.1155/2012/636474 10.1242/dmm.039719 10.1016/j.biomaterials.2019.119396 10.3389/fmicb.2018.03265 10.1038/nbt.1614 10.1038/nbt.4072 10.1038/nbt.3703 10.1016/j.ymben.2003.09.002 10.1016/j.micres.2020.126540 10.1046/j.1365-2672.1999.00632.x 10.1371/journal.pone.0097864 10.1111/myc.12145 10.1007/s00253-015-6984-4 10.1038/s41396-020-00848-z 10.1038/ng.605 10.1080/21505594.2019.1688753 10.1186/s40168-019-0704-8 10.3390/nu12041107 10.1038/s41598-020-58069-5 10.1186/s12866-021-02178-2 10.1093/femsec/fiz187 10.1038/s41598-019-45467-7 10.1016/j.cmet.2018.01.005 10.1371/journal.pbio.1001424 10.1093/mmy/myaa080 10.1371/journal.pgen.1004567 10.1038/s41467-019-09599-8 10.1371/journal.ppat.1007823 10.1080/21505594.2015.1109766 10.3389/fcimb.2021.636834 10.1371/journal.ppat.1000612 10.1016/j.cmet.2018.03.019 10.1371/journal.pgen.1008582 10.1128/IAI.00817-06 10.1128/EC.00155-06 10.1371/journal.ppat.1009661 10.1016/j.ijmm.2019.151330 10.1091/mbc.e12-06-0477 10.1128/mBio.00206-20 10.1016/j.febslet.2011.02.005 10.1128/EC.00295-09 10.1371/journal.pone.0184438 10.1099/jmm.0.000226 10.1007/978-1-62703-290-2_7 10.1093/bioinformatics/btv428 10.1093/nar/gkab382 10.1007/978-1-61779-539-8_28 10.1016/j.micinf.2011.06.009 10.1371/journal.pone.0101717 10.1093/nar/gkw924 10.1371/journal.pone.0021800 10.1186/1752-0509-7-74
Nature Communications; Alonso-Roman R, Last A et. al.

Jun 11th, 2022 - Intestinal microbiota dysbiosis can initiate overgrowth of commensal Candida species - a major predisposing factor for disseminated candidiasis. Commensal bacteria such as Lactobacillus rhamnosus can antagonize Candida albicans pathogenicity. Here, we investigate the interplay between C. albicans, L. rhamnosus, and intestinal epithelial cells by integrating transcriptional and metabolic profili...

Quality assurance practices in tuberculosis diagnostic health facilities in Ethiopia.
https://doi.org/10.1371/journal.pone.0269601
PloS One; Abebaw Y, Kebede A et. al.

Jun 10th, 2022 - The quality of tuberculosis laboratory services in health facilities is a mandatory component of detecting active pulmonary TB cases and treatment follow-up. However, ensuring the quality of laboratory test results is a concern. This study aimed to assess the quality assurance practices in the tuberculosis diagnostic health facilities of Ethiopia. A cross-sectional study was conducted from Octo...

Fecal microbiota in congenital chloride diarrhea and inflammatory bowel disease.
https://doi.org/10.1371/journal.pone.0269561
PloS One; Wedenoja S, Saarikivi A et. al.

Jun 10th, 2022 - Subjects with congenital chloride diarrhea (CLD; a defect in solute carrier family 26 member 3 (SLC26A3)) are prone to inflammatory bowel disease (IBD). We investigated fecal microbiota in CLD and CLD-associated IBD. We also tested whether microbiota is modulated by supplementation with the short-chain fatty acid butyrate. We recruited 30 patients with CLD for an observational 3-week follow-up ...

Common condition with uncommon cause: fungal folliculitis in immunosuppressed patient w...
https://doi.org/10.1136/bcr-2021-243565
BMJ Case Reports; Ebadian M, Barbieri A et. al.

Jun 9th, 2022 - We present a case of a patient with a history of Blau syndrome, who presented with acute onset of widespread florid painful folliculitis rash, which was resistant to the treatment with multiple courses of antibiotics in the community. Despite of the negative skin swab and negative periodic acid-schiff (PAS)stain on the skin biopsy, clinical diagnosis was fungal folliculitis and patient responde...

Clinical and microbiological features of obstructive cholangitis with bloodstream infec...
https://doi.org/10.1186/s12879-022-07514-z 10.1099/00207713-50-2-887 10.1128/JCM.39.5.1819-1826.2001 10.1186/s12879-019-4420-6 10.1016/S0140-6736(16)00576-6 10.1186/s12890-017-0373-y 10.1378/chest.117.6.1661 10.1128/JCM.44.4.1359-1366.2006 10.1128/JCM.00855-08 10.1111/j.1574-6968.2002.tb11053.x 10.1128/JCM.05730-11 10.1128/JCM.41.5.2255-2257.2003 10.1097/01.inf.0000136857.74561.3c 10.1016/j.medcli.2016.04.009 10.2147/IDR.S227643 10.1016/j.jccase.2020.12.003 10.2147/IDR.S301138 10.1201/9781498747967 10.1128/AAC.50.4.1330-1335.2006 10.1128/AAC.01112-15
BMC Infectious Diseases; Itoh N, Akazawa N et. al.

Jun 8th, 2022 - Pandoraea species are multidrug-resistant glucose-nonfermenting gram-negative bacilli that are usually isolated from patients with cystic fibrosis (CF) and from water and soil. Reports of diseases, including bloodstream infections, caused by Pandoraea spp. in non-CF patients are rare, and the clinical and microbiological characteristics are unclear. The identification of Pandorea spp. is limite...

Critical approach to atypical spectrum of melioidosis: a case-series based literature r...
https://doi.org/10.1136/bcr-2022-249417
BMJ Case Reports; Sharma A, Mahajan Z et. al.

Jun 7th, 2022 - Melioidosis is an emerging infectious disease with highest predominance in Southeast Asia, but it has a significantly lower incidence across other parts of the globe. The most common systemic involvement seen in melioidosis is pulmonary, followed by multiple visceral and cutaneous abscesses. Infrequently, melioidosis manifests with atypical presentations such as spontaneous bacterial peritoniti...

A case of recurrent acute cholecystitis caused by Actinomyces odontolyticus, rare actin...
https://doi.org/10.1186/s12879-022-07491-3 10.1186/s13023-021-01821-5 10.2174/1874437000802010105 10.1136/bcr-2014-204559 10.1097/00007611-198008000-00034 10.1016/S0163-4453(87)92753-8 10.7869/tg.226 10.3348/kjr.2007.8.2.169 10.1002/jhbp.518 10.1186/s12879-021-06703-6
BMC Infectious Diseases; Furuya K, Ito K et. al.

Jun 7th, 2022 - Actinomyces species are gram-positive, obligate anaerobic rods and are rare causes of cholecystitis. Because Actinomyces species are anaerobic bacteria, it is difficult for Actinomyces to survive in bile apart from A. naeslundii. We experienced a case of recurrent acute cholecystitis caused by A. odontolyticus. A patient had been diagnosed with acute cholecystitis and treated one month before a...