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About 60,128 results

Nonselective β blockers increase risk for hepatorenal syndrome and death in patients wi...
https://doi.org/10.1053/j.gastro.2014.03.005
Gastroenterology Mandorfer M, Bota S et. al.

Mar 18th, 2014 - Nonselective β blockers (NSBBs) reduce portal pressure and the risk for variceal hemorrhage in patients with cirrhosis. However, development of spontaneous bacterial peritonitis (SBP) in these patients could preclude treatment with NSBBs because of their effects on the circulatory reserve. We investigated the effects of NSBBs in patients with cirrhosis and ascites with and without SBP. We perfo...

Actionable diagnosis of neuroleptospirosis by next-generation sequencing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134948
The New England Journal of Medicine; Wilson MR, Naccache SN et. al.

Jun 4th, 2014 - A 14-year-old boy with severe combined immunodeficiency presented three times to a medical facility over a period of 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically induced coma. Diagnostic workup including brain biopsy was unrevealing. Unbiased next-generation sequencing of the cerebrospinal fluid identified 475 of 3,063,784 se...

Multidrug-resistant tuberculosis and culture conversion with bedaquiline.
https://doi.org/10.1056/NEJMoa1313865
The New England Journal of Medicine; Diacon AH, Pym A et. al.

Aug 20th, 2014 - Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with accelerated sputum-culture conversion in patients with multidrug-resistant tuberculosis, when added to a preferred background regimen for 8 weeks. In this phase 2b trial, we randomly assigned 160 patients with newly diagnosed, smear-positive, multidrug-resistant tuberculosis to re...

A Cluster of CNS Infections Due to B. cereus in the Setting of Acute Myeloid Leukemia: ...
https://doi.org/10.1097/NEN.0000000000000244
Journal of Neuropathology and Experimental Neurology; Vodopivec I, Rinehart EM et. al.

Sep 9th, 2015 - Bacillus cereus typically causes a self-limited foodborne gastrointestinal (GI) illness. Severe invasive infection occurs rarely, mainly among immunocompromised hosts. We describe a cluster of B. cereus infections among 5 patients with acute myeloid leukemia and chemotherapy-induced neutropenia. The initial case presented with occipital lobe abscess and was found on biopsy to have organisms con...

Small bowel bacterial overgrowth in adults: a potential contributor to intestinal failure.
https://www.ncbi.nlm.nih.gov/pubmed/18377796
Current Gastroenterology Reports; Ziegler TR, Cole CR

Apr 1st, 2008 - Small bowel bacterial overgrowth (SBBO), in which colon-derived bacteria colonize the upper small bowel, is found in a wide variety of adult diseases associated with intestinal failure and dysfunction, including short bowel syndrome and other conditions following massive bowel resection, dysmotility disorders, and inflammatory bowel disease. SBBO also appears to be relatively common in the elde...

Synergistic activity of rifampicin and ethambutol against slow-growing nontuberculous m...
https://doi.org/10.1016/j.ijantimicag.2013.03.010
International Journal of Antimicrobial Agents; van Ingen J, Hoefsloot W et. al.

May 14th, 2013 - A key issue in the treatment of disease caused by slow-growing nontuberculous mycobacteria is the limited association between in vitro minimum inhibitory concentrations (MICs) of rifampicin and ethambutol alone and the in vivo outcome of treatment with these drugs. Combined susceptibility testing to rifampicin and ethambutol could provide a more realistic view of the efficacy of these drugs. In...

Efficacy of preoperative itraconazole in allergic fungal rhinosinusitis.
https://doi.org/10.2500/ajra.2015.29.4187
American Journal of Rhinology & Allergy; Patro SK, Verma RK et. al.

Jul 14th, 2015 - Criterion standard treatment of allergic fungal sinusitis (AFS) is primary surgery followed by adjuvant therapy. Even after good surgery, recurrence rates vary from 10 to 79%. Antifungals, e.g., itraconazole, and steroids have shown varying success rates in delaying recurrences given after surgery. Itraconazole decreases the need for steroids given as a primary treatment in allergic bronchopulm...

Mycobacterium bovis in Burkina Faso: epidemiologic and genetic links between human and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183478
PLoS Neglected Tropical Diseases; Sanou A, Tarnagda Z et. al.

Oct 2nd, 2014 - In sub-Saharan Africa, bovine tuberculosis (bTB) is a potential hazard for animals and humans health. The goal of this study was to improve our understanding of bTB epidemiology in Burkina Faso and especially Mycobacterium bovis transmission within and between the bovine and human populations. Twenty six M. bovis strains were isolated from 101 cattle carcasses with suspected bTB lesions during ...

Epidemiology and outcomes of deep surgical site infections following lung transplantation.
https://doi.org/10.1111/ajt.12292
American Journal of Transplantation : Official Journal Of... Shields RK, Clancy CJ et. al.

May 28th, 2013 - We conducted a retrospective study of deep surgical site infections (SSIs) among consecutive patients who underwent lung transplantation (LTx) at a single center from 2006 through 2010. Thirty-one patients (5%) developed SSIs at median 25 days after LTx. Empyema was most common (42%), followed by surgical wound infections (29%), mediastinitis (16%), sternal osteomyelitis (6%), and pericarditis ...

Nocardia infections among immunomodulated inflammatory bowel disease patients: A review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458760
World Journal of Gastroenterology; Abreu C, Rocha-Pereira N et. al.

Jun 15th, 2015 - Human nocardiosis, caused by Nocardia spp., an ubiquitous soil-borne bacteria, is a rare granulomatous disease close related to immune dysfunctions. Clinically can occur as an acute life-threatening disease, with lung, brain and skin being commonly affected. The infection was classically diagnosed in HIV infected persons, organ transplanted recipients and long term corticosteroid treated patien...

The effectiveness of BCG vaccination in preventing Mycobacterium tuberculosis infection...
https://doi.org/10.1136/thoraxjnl-2014-205688
Thorax Michelsen SW, Soborg B et. al.

Jun 27th, 2014 - The BCG vaccine's ability to prevent Mycobacterium tuberculosis infection (MTI) remains highly debated. In Greenland, BCG vaccination was introduced in 1955, but was temporarily discontinued (1991-1996) due to nationwide policy changes. The study aimed to use the transient stop in BCG vaccination to evaluate the effect of vaccination on MTI prevalence and TB incidence. MTI study: A cross-sectio...

Microbiologic characterization and antimicrobial susceptibility of Clostridium tetani i...
https://www.ncbi.nlm.nih.gov/pubmed/19407132
The American Journal of Tropical Medicine and Hygiene; Campbell JI, Lam TM et. al.

May 1st, 2009 - Clostridium tetani is the etiologic agent of the muscle-spasming disease tetanus. Despite an effective vaccine, tetanus is an ongoing problem in some developing countries. Diagnosis by bacterial culture is not done because it is generally unnecessary and the entry of route of the bacteria can be inapparent. We attempted to isolate and evaluate C. tetani from the wounds of 84 patients with tetan...

Coccidioidomycosis during pregnancy: a review and recommendations for management.
https://doi.org/10.1093/cid/cir410
Clinical Infectious Diseases : an Official Publication Of... Bercovitch RS, Catanzaro A et. al.

Aug 3rd, 2011 - Pregnancy is an established risk factor for the development of severe and disseminated coccidioidomycosis, particularly when infection is acquired during the later stages of gestation. Although recent studies suggest that the incidence of symptomatic coccidioidomycosis during pregnancy is decreasing and that outcome has improved, management is complicated by the observations that azole antifung...

Mycobacterium xenopi clinical relevance and determinants, the Netherlands.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570832
Emerging Infectious Diseases; van Ingen J, Boeree MJ et. al.

Mar 7th, 2008 - In the Netherlands, isolation of Mycobacterium xenopi is infrequent, and its clinical relevance is often uncertain. To determine clinical relevance and determinants, we retrospectively reviewed medical files of all patients in the Netherlands in whom M. xenopi was isolated from January 1999 through March 2005 by using diagnostic criteria for nontuberculous mycobacterial infection published by t...

Clinical outcomes in infants with cystic fibrosis transmembrane conductance regulator (...
https://doi.org/10.1002/ppul.21475
Pediatric Pulmonology; Ren CL, Desai H et. al.

May 3rd, 2011 - An unavoidable outcome of cystic fibrosis newborn screening (CF NBS) programs is the detection of infants with an indeterminate diagnosis. The United States CF Foundation recently proposed the term cystic fibrosis transmembrane conductance regulator related metabolic syndrome (CRMS) to describe infants with elevated immunoreactive trypsinogen (IRT) on NBS who do not meet diagnostic criteria for...

Mycobacterial genotypes are associated with clinical manifestation and progression of l...
https://doi.org/10.1093/cid/cit172
Clinical Infectious Diseases : an Official Publication Of... Shin SJ, Choi GE et. al.

Mar 20th, 2013 - Mycobacterium abscessus and Mycobacterium massiliense, which cause lung disease, are variable in their clinical manifestation and progression. We hypothesized that mycobacterial genotypes represent their pathogenic phenotypes, which would result in particular genotypes being associated with disease progression. Variable number tandem repeat (VNTR) loci were selected to establish a genotype assa...

Risk of Buruli ulcer and detection of Mycobacterium ulcerans in mosquitoes in southeast...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176747
PLoS Neglected Tropical Diseases; Lavender CJ, Fyfe JA et. al.

Sep 28th, 2011 - Buruli ulcer (BU) is a destructive skin condition caused by infection with the environmental bacterium, Mycobacterium ulcerans. The mode of transmission of M. ulcerans is not completely understood, but several studies have explored the role of biting insects. In this study, we tested for an association between the detection of M. ulcerans in mosquitoes and the risk of BU disease in humans in an...

Enhanced Identification of Group B Streptococcus and Escherichia Coli in Young Infants ...
https://doi.org/10.1097/INF.0000000000001551
The Pediatric Infectious Disease Journal; Arora HS, Asmar BI et. al.

Jan 23rd, 2017 - FilmArray Meningitis/Encephalitis (ME) polymerase chain reaction (PCR) panel was tested on 62 cerebrospinal fluid (CSF) samples from young infants (0-3 months) with suspected meningitis and compared with CSF cultures. Twelve CSF samples from 9 infants were positive by ME PCR panel (10 Group B Streptococcus (GBS) and 2 Escherichia coli) of which only 5 were positive by culture. The 7 CSF samples...

Micafungin treatment and eradication of candiduria among hospitalized patients.
https://doi.org/10.1007/s11255-016-1410-0
International Urology and Nephrology; Gabardi S, Martin S et. al.

Sep 2nd, 2016 - In high-risk patients, candiduria may be associated with the development of urinary tract infections (UTI) and invasive candidiasis. The triazole antifungals achieve good urine concentrations, but their use is limited by the emergence of non-albicans Candida spp. with low-triazole susceptibility. The echinocandins remain fungicidal against many azole-resistant Candida spp., but low urine concen...

Congenital and opportunistic infections: Ureaplasma species and Mycoplasma hominis.
https://doi.org/10.1016/j.siny.2008.11.009
Seminars in Fetal & Neonatal Medicine; Waites KB, Schelonka RL et. al.

Dec 25th, 2008 - There is strong evidence from clinical and experimental animal studies that ureaplasmas can invade the amnionic sac and induce an inflammatory response resulting in chorioamnionitis, preterm labor and neonatal lung injury. The ability of Ureaplasma spp. and Mycoplasma hominis to cause pneumonia, bacteremia, and meningitis in newborns can no longer be questioned. The association of Ureaplasma sp...