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About 341,350 results

Colonic expression of Ace2, the SARS-CoV-2 entry receptor, is suppressed by commensal h...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510562
Gut Microbes; Edwinson A, Yang L et. al.

Oct 12th, 2021 - Infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Angiotensin-converting enzyme 2 (Ace2) is expressed in the gastrointestinal (GI) tract and a receptor for SARS-CoV-2, making the GI tract a potential infection site. This study investigated the effects of commensal intestinal microbiota on colonic Ace2 expression using a humaniz...

First Drug for Dengue Found to Be Effective in Mice; Human Clinical Trials Starting
https://www.medscape.com/viewarticle/960589

Oct 11th, 2021 - Researchers at KU Leuven Rega Institute and Center for Drug Design and Discovery (CD3), Leuven, Belgium, have identified a new target for treating dengue in collaboration with Jannsen Pharmaceutica, NV. As reported in Nature, the antiviral compound showed strong activity in mice for prophylaxis against dengue and for treatment of the infection. Dengue is a viral infection acquired through the b...

Infectious Keratitis in 2021.
https://doi.org/10.1001/jama.2021.0424
JAMA Durand ML, Barshak MB et. al.

Oct 6th, 2021 - Infectious Keratitis in 2021.|2021|Durand ML,Barshak MB,Chodosh J,|drug therapy,parasitology,adverse effects,microbiology,drug therapy,microbiology,drug therapy,microbiology,drug therapy,virology,diagnosis,microbiology,virology,drug therapy,virology,

Laboratory Tests in the Patient with Abdominal Pain.
https://doi.org/10.1016/j.emc.2021.08.001
Emergency Medicine Clinics of North America; Natesan S, Werley EB

Oct 4th, 2021 - Abdominal pain is one of the most common presenting complaints to the emergency department (ED). More often than not, some degree of laboratory testing is used to narrow the differential diagnosis based on the patient's history and examination. Ordering practices are often guided by evidence, habit, consulting services, and institutional/regional culture. This review highlights relevant laborat...

Application of loop-mediated isothermal amplification and next-generation sequencing in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483829
Medicine Li H, Wu Q et. al.

Oct 2nd, 2021 - Tuberculosis (TB) is one of the top 10 causes of death worldwide and is the leading infectious cause of death. The incidence of TB, especially active TB, is increased in pregnant and postpartum women. Newborns can be infected with TB from their mothers through several routes. Diagnosis of TB in pregnant women and infants is difficult. Here, we report the simultaneous postdelivery diagnosis of T...

Lung microbiota and COVID-19 severity.
https://doi.org/10.1038/s41564-021-00969-x 10.1513/AnnalsATS.202009-1225RL 10.1164/rccm.201703-0614LE 10.14814/phy2.14693 10.1001/jamainternmed.2020.3313 10.1038/s41586-020-03148-w 10.1164/rccm.201907-1487OC 10.1164/rccm.201711-2180OC
Nature Microbiology; Dickson RP

Sep 29th, 2021 - Lung microbiota and COVID-19 severity.|2021|Dickson RP,|immunology,microbiology,pathology,virology,immunology,microbiology,pathology,virology,immunology,pathogenicity,

Adolescents may accurately self-collect pharyngeal and rectal clinical specimens for th...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475974
PloS One; Vavala G, Goldbeck C et. al.

Sep 28th, 2021 - The COVID-19 pandemic illuminated the benefits of telemedicine. Self-collected specimens are a promising alternative to clinician-collected specimens when in-person testing is not feasible. In this study, we assessed the adequacy of self-collected pharyngeal and rectal specimens for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae among individuals undergoing chlamydia and gonor...

Bacterial and fungal growth in sputum cultures from 165 COVID-19 pneumonia patients req...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465781
Annals of Clinical Microbiology and Antimicrobials; Liu HH, Yaron D et. al.

Sep 27th, 2021 - Coronavirus SARS-CoV-2 causes COVID-19 illness which can progress to severe pneumonia. Empiric antibacterials are often employed though frequency of bacterial coinfection superinfection is debated and concerns raised about selection of bacterial antimicrobial resistance. We evaluated sputum bacterial and fungal growth from 165 intubated COVID-19 pneumonia patients. Objectives were to determine ...

Gastric microbiota in patients with Helicobacter pylori-negative gastric MALT lymphoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462607
Medicine Tanaka T, Matsuno Y et. al.

Sep 25th, 2021 - To investigate the mucosal microbiota in the stomach of patients with Helicobacter pylori-negative mucosa-associated lymphoid tissue (MALT) lymphoma by means of metagenomic analysis.Although some gastric MALT lymphomas are associated with the presence of H. pylori, other gastric MALT lymphomas occur independently of H. pylori infection. The pathogenesis of H. pylori-negative MALT lymphoma remai...

Decreased Incidence of Infections Caused by Pathogens Transmitted Commonly Through Food...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459900
MMWR. Morbidity and Mortality Weekly Report; Ray LC, Collins JP et. al.

Sep 24th, 2021 - Foodborne illnesses are a substantial and largely preventable public health problem; before 2020 the incidence of most infections transmitted commonly through food had not declined for many years. To evaluate progress toward prevention of foodborne illnesses in the United States, the Foodborne Diseases Active Surveillance Network (FoodNet) of CDC's Emerging Infections Program monitors the incid...

Chains of evidence from correlations to causal molecules in microbiome-linked diseases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480537
Nature Chemical Biology; Chaudhari SN, McCurry MD et. al.

Sep 24th, 2021 - Human-associated microorganisms play a vital role in human health, and microbial imbalance has been linked to a wide range of disease states. In this Review, we explore recent efforts to progress from correlative studies that identify microorganisms associated with human disease to experiments that establish causal relationships between microbial products and host phenotypes. We propose that su...

A single mutation weakens symbiont-induced reproductive manipulation through reductions...
https://doi.org/10.1073/pnas.2113271118
Proceedings of the National Academy of Sciences of the Un... Beckmann JF, Van Vaerenberghe K et. al.

Sep 23rd, 2021 - Animals interact with microbes that affect their performance and fitness, including endosymbionts that reside inside their cells. Maternally transmitted Wolbachia bacteria are the most common known endosymbionts, in large part because of their manipulation of host reproduction. For example, many Wolbachia cause cytoplasmic incompatibility (CI) that reduces host embryonic viability when Wolbachi...

Altered gut microbial metabolites could mediate the effects of risk factors in Covid-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995004
Reviews in Medical Virology; Chen J, Hall S et. al.

Sep 22nd, 2021 - Coronavirus disease 2019 (Covid-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is now pandemic. While most Covid-19 patients will experience mild symptoms, a small proportion will develop severe disease, which could be fatal. Clinically, Covid-19 patients manifest fever with dry cough, fatigue and dyspnoea, and in severe cases develop into acute respirato...

Predictors of unfavorable responses to therapy in rifampicin-sensitive pulmonary tuberc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452066
PloS One; Gopalan N, Srinivasalu VA et. al.

Sep 21st, 2021 - Despite the exalted status of sputum mycobacterial load for gauging pulmonary tuberculosis treatment and progress, Chest X-rays supplement valuable information for taking instantaneous therapeutic decisions, especially during the COVID-19 pandemic. Even though literature on individual parameters is overwhelming, few studies have explored the interaction between radiographic parameters denoting ...

The Arabidopsis MIK2 receptor elicits immunity by sensing a conserved signature from ph...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448819
Nature Communications; Hou S, Liu D et. al.

Sep 19th, 2021 - Sessile plants encode a large number of small peptides and cell surface-resident receptor kinases, most of which have unknown functions. Here, we report that the Arabidopsis receptor kinase MALE DISCOVERER 1-INTERACTING RECEPTOR-LIKE KINASE 2 (MIK2) recognizes the conserved signature motif of SERINE-RICH ENDOGENOUS PEPTIDEs (SCOOPs) from Brassicaceae plants as well as proteins present in fungal...

Ocular Surface Microbiota in Diabetic Patients With Dry Eye Disease.
https://doi.org/10.1167/iovs.62.12.13
Investigative Ophthalmology & Visual Science; Zhang Z, Zou X et. al.

Sep 16th, 2021 - To investigate the ocular surface (OS) commensal bacteria profiles of patients with diabetes mellitus (DM) and dry eye disease (DED). In the present study, subjects were assigned to four groups: 37 to the diabetic mellitus with dry eye disease (DM with DED) group, 22 to the diabetes mellitus (DM)-only group, 34 to the dry eye disease (DED)-only group, and 22 to the control group. Tear fluid was...

Oligonucleotide aptamers for pathogen detection and infectious disease control.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419047
Theranostics Wan Q, Liu X et. al.

Sep 16th, 2021 - During an epidemic or pandemic, the primary task is to rapidly develop precise diagnostic approaches and effective therapeutics. Oligonucleotide aptamer-based pathogen detection assays and control therapeutics are promising, as aptamers that specifically recognize and block pathogens can be quickly developed and produced through simple chemical synthesis. This work reviews common aptamer-based ...

Factors behind the prevalence of carbapenem-resistant Klebsiella pneumoniae in pediatri...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428699
Medicine Yang Y, Liu J et. al.

Sep 14th, 2021 - The emergence of carbapenem-resistant Enterobacteriaceae made the treatment difficult, which has become a significant issue of public health. A sharp increase of carbapenem-resistance rate in Klebsiella pneumoniae was observed in a maternity and child health care hospital in Zunyi, China, in 2014.In 2015 to 2016, carbapenem-resistant Klebsiella pneumoniae (CRKp) isolated from all the clinical s...

Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457559
Aging Bourgin M, Derosa L et. al.

Sep 14th, 2021 - Cancer patients are particularly susceptible to the development of severe Covid-19, prompting us to investigate the serum metabolome of 204 cancer patients enrolled in the ONCOVID trial. We previously described that the immunosuppressive tryptophan/kynurenine metabolite anthranilic acid correlates with poor prognosis in non-cancer patients. In cancer patients, we observed an elevation of anthra...

RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416739
International Journal of Biological Sciences; Liu T, Wu J et. al.

Sep 14th, 2021 - An inflammatory cytokine storm is considered an important cause of death in severely and critically ill COVID-19 patients, however, the relationship between the SARS-CoV-2 spike (S) protein and the host's inflammatory cytokine storm is not clear. Here, the qPCR results indicated that S protein induced a significantly elevated expression of multiple inflammatory factor mRNAs in peripheral blood ...