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About 160,208 results

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Potential Implications of Mammalian Transient Receptor Potential Melastatin 7 in the Pa...
https://doi.org/10.3390/ijerph182010708
International Journal of Environmental Research and Publi... Du Preez S, Cabanas H et. al.

Oct 24th, 2021 - The transient receptor potential (TRP) superfamily of ion channels is involved in the molecular mechanisms that mediate neuroimmune interactions and activities. Recent advancements in neuroimmunology have identified a role for TRP cation channels in several neuroimmune disorders including amyotropic lateral sclerosis, multiple sclerosis, and myalgic encephalomyelitis/chronic fatigue syndrome (M...

Molecular response to PARP1 inhibition in ovarian cancer cells as determined by mass sp...
https://doi.org/10.1186/s13048-021-00886-x
Journal of Ovarian Research; Franz A, Coscia F et. al.

Oct 24th, 2021 - Poly (ADP)-ribose polymerase (PARP) inhibitors have entered routine clinical practice for the treatment of high-grade serous ovarian cancer (HGSOC), yet the molecular mechanisms underlying treatment response to PARP1 inhibition (PARP1i) are not fully understood. Here, we used unbiased mass spectrometry based proteomics with data-driven protein network analysis to systematically characterize how...

Collapse of complexity of brain and body activity due to excessive inhibition and MeCP2...
https://doi.org/10.1073/pnas.2106378118
Proceedings of the National Academy of Sciences of the Un... Li J, Kells PA et. al.

Oct 24th, 2021 - Complex body movements require complex dynamics and coordination among neurons in motor cortex. Conversely, a long-standing theoretical notion supposes that if many neurons in motor cortex become excessively synchronized, they may lack the necessary complexity for healthy motor coding. However, direct experimental support for this idea is rare and underlying mechanisms are unclear. Here we reco...

SARS-CoV-2 Spike Protein Disrupts Blood-Brain Barrier Integrity via RhoA Activation.
https://doi.org/10.1007/s11481-021-10029-0 10.1016/j.brainres.2015.04.054 10.3109/10739689409146752 10.1186/2045-8118-10-5 10.1007/s11481-021-09986-3 10.1038/nrm1357 10.1016/j.febslet.2007.11.085 10.1038/ncomms7725 10.1038/s41591-021-01283-z 10.1186/s13054-020-03120-0 10.1093/ageing/afaa094 10.1016/j.biomaterials.2016.11.012 10.1093/infdis/jiaa332 10.1007/s11481-020-09975-y 10.1161/HYPERTENSIONAHA.113.01274 10.1091/mbc.9.2.403 10.1016/j.jns.2005.06.003 10.1016/j.bbrc.2020.02.151 10.1096/fj.04-3458fje 10.1111/j.1471-4159.2008.05723.x 10.1016/j.thromres.2019.02.016 10.2353/ajpath.2008.070076 10.1111/jcmm.13471
Journal of Neuroimmune Pharmacology : the Official Journa... DeOre BJ, Tran KA et. al.

Oct 24th, 2021 - The SARS-CoV-2 spike protein has been shown to disrupt blood-brain barrier (BBB) function, but its pathogenic mechanism of action is unknown. Whether angiotensin converting enzyme 2 (ACE2), the viral binding site for SARS-CoV-2, contributes to the spike protein-induced barrier disruption also remains unclear. Here, a 3D-BBB microfluidic model was used to interrogate mechanisms by which the spik...

Parkinsonism and tremor syndromes.
https://doi.org/10.1016/j.jns.2021.120018
Journal of the Neurological Sciences; Bellows S, Jankovic J

Oct 24th, 2021 - Tremor, the most common movement disorder, may occur in isolation or may co-exist with a variety of other neurologic and movement disorders including parkinsonism, dystonia, and ataxia. When associated with Parkinson's disease, tremor may be present at rest or as an action tremor overlapping in phenomenology with essential tremor. Essential tremor may be associated not only with parkinsonism bu...

Lithium toxicity at therapeutic doses as a fallout of COVID-19 infection: a case series...
https://doi.org/10.1097/YIC.0000000000000379
International Clinical Psychopharmacology; Pai NM, Malyam V et. al.

Oct 24th, 2021 - Lithium, a mood stabilizer used in the treatment of bipolar disorder is known for its anti-inflammatory properties with the discussion of its potential use in COVID-19 infection. The SARS-CoV-2 virus causing COVID-19 infection is known to enter the target cells through angiotensin converting enzyme-2 receptors present in abundance in the lung and renal tissue. Recent research supports the evide...

Axonal damage determines clinical disability in chronic inflammatory demyelinating poly...
https://doi.org/10.1111/ene.15156
European Journal of Neurology; Grüter T, Motte J et. al.

Oct 24th, 2021 - Monitoring of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is challenging in daily medical practice since the interrelation between clinical disability, the CIDP subtype, and neuronal degeneration is still elusive. This prospective cohort study investigates the role of different electrophysiological parameters for CIDP monitoring. Comprehensive bilateral nerve ...

Reinnervation as measured by the motor unit size index is associated with preservation ...
https://doi.org/10.1002/mus.27444
Muscle & Nerve; Chan Y, Alix JJP et. al.

Oct 24th, 2021 - The motor unit size index (MUSIX) may provide insight into reinnervation patterns in diseases such as amyotrophic lateral sclerosis (ALS). However, it is not known if MUSIX detects clinically relevant changes in reinnervation, or if all muscles manifest changes in MUSIX in response reinnervation following motor unit loss. 57 patients with ALS were assessed at 3-monthly intervals for 12 months i...

Regulation of autophagy as a therapeutic option in glioblastoma.
https://doi.org/10.1007/s10495-021-01691-z 10.22034/APJCP.2018.19.9.2613 10.1056/NEJMoa043330 10.1158/0008-5472.CAN-16-2983 10.1056/NEJMoa043331 10.5732/cjc.013.10207 10.1158/0008-5472.CAN-06-0127 10.1038/nature03128 10.1126/science.1254257 10.1038/nrc3918 10.1093/neuonc/nov164 10.1101/gad.261982.115 10.18388/pb.2018_121 10.1097/NEN.0b013e31823fe8f1 10.1016/j.cell.2013.09.034 10.1007/s00401-015-1432-1 10.1016/B978-0-323-35762-3.00018-4 10.1002/ijc.29990 10.1016/j.brainresbull.2019.09.012 10.3390/ijms15023145 10.1016/j.cmet.2017.04.004 10.1016/S1474-4422(07)70076-5 10.3390/cancers11030312 10.15252/embj.201490784 10.1158/1078-0432.CCR-10-2634 10.1016/j.cell.2013.05.039 10.1038/ncb2788 10.1242/jcs.051011 10.4161/auto.23323 10.1007/s10014-011-0029-1 10.1038/ng.2734 10.1016/j.bbcan.2016.11.003 10.4161/cc.27518 10.1016/j.cell.2009.03.048 10.1080/15548627.2015.1009767 10.1007/s12253-017-0310-7 10.1038/cddis.2013.338 10.1038/nature16187 10.4161/cc.10.8.15330 10.1038/nature09557 10.1038/onc.2012.111 10.1038/sj.cdd.4402030 10.1111/j.1440-1789.2010.01197.x 10.1080/15548627.2015.1009795 10.3171/foc.2006.20.4.4 10.1016/j.cell.2004.11.046 10.1038/nature11287 10.1038/cdd.2014.31 10.1186/1475-2867-13-119 10.1038/bjc.2016.19 10.1016/s0304-419x(03)00004-0 10.1038/sj.cdd.4401359 10.1200/JCO.2008.19.8721 10.1200/JCO.2008.16.3055 10.1093/jjco/hys121 10.1200/JCO.2007.12.2440 10.1158/0008-5472.CAN-06-1010 10.1016/B978-0-323-47660-7.00010-0 10.1016/j.pharmthera.2017.10.017 10.1158/0008-5472.CAN-11-3831 10.1227/NEU.0b013e3182314f9d 10.1016/j.ejphar.2015.12.017 10.1016/j.canlet.2015.02.012 10.4161/auto.28984 10.1016/j.semcancer.2020.05.015 10.1111/bph.14816 10.1038/cddis.2014.467 10.1080/15548627.2015.1056970 10.1007/s11064-019-02802-8 10.1007/s10495-015-1198-x 10.1371/journal.pone.0158537 10.1371/journal.pone.0072882 10.22038/IJBMS.2016.7472 10.1016/j.freeradbiomed.2011.10.487 10.1038/cddis.2014.182 10.1074/jbc.M113.528760 10.1016/j.cbi.2013.06.004 10.18632/oncotarget.11396 10.1158/1055-9965.EPI-07-2917 10.1016/j.cbi.2014.04.017 10.1016/j.canlet.2014.09.039 10.1016/j.bbamcr.2017.05.008 10.1016/B978-0-323-47660-7.00019-7 10.1016/B978-0-12-819609-0.00003-1 10.1016/j.actbio.2019.01.020 10.1016/j.biomaterials.2014.03.041 10.1016/j.bcp.2019.03.023 10.1016/B978-0-323-47660-7.00006-9 10.1001/jama.2015.16669 10.1038/cddis.2017.171 10.1038/nrg1879 10.1074/jbc.M109.080796 10.1007/s11010-013-1835-z 10.1080/15548627.2018.1501133 10.1111/cas.12422 10.4196/kjpp.2011.15.4.211 10.1111/j.1432-1033.1997.0240a.x 10.1016/j.ejca.2012.06.027 10.1186/1748-717X-6-156 10.1097/CAD.0000000000000463 10.1038/cddis.2013.142 10.1158/1078-0432.CCR-14-3147 10.3390/nu8030167 10.1155/2013/596496 10.1016/j.molcel.2015.05.031 10.1080/15548627.2018.1474314 10.18632/oncotarget.4239 10.1016/j.biopha.2019.109339 10.1001/archophthalmol.2010.321 10.3390/ijms19123773 10.1023/a:1008209720526 10.1016/B978-0-323-47660-7.00002-1 10.1016/B978-0-323-47660-7.00003-3 10.1016/j.yexcr.2014.05.011 10.1007/s11060-011-0632-3 10.1002/iub.1445 10.3892/ijo.32.4.829 10.3892/ijo_00000563 10.1074/jbc.270.5.2320 10.1093/neuonc/nov152 10.5732/cjc.011.10234 10.1002/ijc.25975 10.1158/0008-5472.CAN-04-4392 10.1158/0008-5472.CAN-04-3640 10.1038/gt.2008.98 10.1007/s11060-014-1680-2 10.1007/s10637-011-9775-5 10.1038/sj.mt.6300400 10.3390/ijms20020399 10.3892/mmr.2016.4796 10.2147/OTT.S149708 10.1016/j.neulet.2006.08.013 10.1042/BSR20140141 10.1038/bjc.2014.529 10.1158/1541-7786.MCR-09-0562 10.1002/ijc.23648 10.1016/j.nano.2020.102270 10.1039/C8TB03165G 10.1016/j.molmed.2019.11.001 10.1016/j.semcancer.2020.03.010 10.1016/j.canlet.2020.01.034 10.1007/s11060-017-2619-1 10.1073/pnas.79.6.1889 10.1016/S0021-9258(17)37680-9 10.1371/journal.pone.0218972 10.1247/csf.23.33 10.1007/s11060-014-1686-9 10.1016/j.femsyr.2004.07.006 10.1007/BF01051046 10.3171/2015.1.FOCUS14767 10.1093/ons/opz374 10.1002/stem.1335 10.2174/1568009618666180308105048 10.1007/s00109-011-0844-1 10.3390/cells9040857 10.1002/cbin.11137 10.1080/01926230701320337 10.3390/ijms19030889 10.4161/cc.20718 10.1016/j.ejphar.2021.174217 10.4103/1673-5374.276322
Apoptosis : an International Journal on Programmed Cell D... Manea AJ, Ray SK

Oct 24th, 2021 - Around three out of one hundred thousand people are diagnosed with glioblastoma multiforme, simply called glioblastoma, which is the most common primary brain tumor in adults. With a dismal prognosis of a little over a year, receiving a glioblastoma diagnosis is oftentimes fatal. A major advancement in its treatment was made almost two decades ago when the alkylating chemotherapeutic agent temo...

Glioma: molecular signature and crossroads with tumor microenvironment.
https://doi.org/10.1007/s10555-021-09997-9 10.1007/s00109-009-0440-9 10.1101/gad.261982.115.tumors 10.1016/j.trecan.2020.01.009 10.1172/JCI89587 10.1007/978-3-030-49270-0_11 10.1016/j.cmet.2019.06.001 10.1212/WNL.0000000000002770 10.1016/j.tranon.2019.10.002 10.3390/cancers11030292 10.1093/neuonc/now005 10.1111/cas.13826 10.1038/s41392-021-00499-2 10.1007/s00401-016-1545-1 10.3389/fimmu.2019.03137 10.1042/BST20180444 10.3390/IJMS160511055 10.1146/annurev-physiol-021119-034627 10.3892/ijmm.2016.2639 10.1158/0008-5472.CAN-17-3551 10.1038/sigtrans.2017.40 10.1093/neuonc/nox054 10.1016/j.neo.2018.11.007 10.1038/nm1517 10.1016/j.jocn.2010.04.021 10.1016/j.ccell.2019.05.003 10.1016/S0945-053X(98)90012-9 10.1002/stem.415 10.3389/FCELL.2021.600506 10.1093/carcin/bgu134 10.1158/0008-5472.CAN-16-2832 10.1097/NEN.0b013e31823fe8f1 10.1158/0008-5472.CAN-11-1031 10.1016/j.trecan.2015.10.009 10.1371/journal.pone.0003655 10.1083/jcb.84.3.495 10.1124/pr.117.014944 10.1007/s00726-011-0867-5 10.3390/ijms20071796 10.1038/NCB1725 10.3390/ijms18112342 10.1186/S12964-020-00589-8 10.1038/onc.2011.563 10.1158/1078-0432.CCR-18-2402 10.3390/ijms20215347 10.1007/s11910-013-0345-4 10.1016/j.jneuroim.2016.05.019 10.1038/s41598-019-47021-x 10.1007/s00401-018-1842-y 10.1038/s41580-019-0134-2 10.1002/(SICI)1098-1136(199903)26:1<55::AID-GLIA6>3.0.CO;2-1 10.1007/s00401-009-0550-z 10.1007/s00401-004-0929-9 10.1007/s00401-011-0802-6 10.3390/cancers12010114 10.1186/s12885-019-6177-0 10.1038/ncomms7999 10.1056/NEJMoa043331 10.1016/j.cell.2013.03.020 10.1038/nature05529 10.1038/s41418-018-0126-3 10.3389/fonc.2018.00164 10.1038/oncsis.2014.36 10.1158/0008-5472.CAN-11-3732 10.1126/science.6320372 10.1002/ana.410360505 10.3390/cancers11091220 10.1097/CCO.0b013e32835b639e 10.1159/000495920 10.1007/S00401-003-0810-2 10.1186/s40425-019-0536-x 10.1016/S0165-5728(99)00203-9 10.1038/s41598-020-72488-4 10.3389/FIMMU.2020.585034 10.1215/15228517-2007-035 10.1016/j.ccell.2017.02.009 10.1515/ISS-2019-0001 10.1186/S12885-019-6384-8 10.1016/j.prp.2020.153141 10.1158/ajc.1938.333 10.1158/0008-5472.CAN-06-1010 10.1016/j.ccr.2006.11.020 10.1080/10717544.2017.1386731 10.1038/s41419-019-1387-6 10.1007/s11060-010-0261-2 10.1073/pnas.102660199 10.1006/cyto.2003.2008 10.1038/sj.onc.1202217 10.1038/nrc.2017.77 10.1038/ncomms5196 10.1016/j.cell.2013.02.021 10.1155/2016/9768183 10.1016/j.jns.2020.116837 10.1038/s41388-020-1308-2 10.1158/0008-5472.CAN-13-2650 10.1007/S12035-018-1385-1 10.1074/mcp.RA118.000644 10.1038/NCB1800 10.1593/neo.05583 10.1007/s11864-019-0619-4 10.3389/fimmu.2020.603911 10.1158/1078-0432.CCR-15-0428 10.1158/0008-5472.CAN-14-0296 10.1016/S1470-2045(12)70090-6 10.1001/jamaoncol.2020.1024 10.1158/1078-0432.CCR-16-0506 10.1186/s12967-017-1202-z 10.1093/neuonc/nou348 10.1093/neuonc/not203 10.1007/s00262-016-1890-x 10.1158/1078-0432.CCR-16-2057 10.1158/1078-0432.CCR-15-2163
Cancer Metastasis Reviews; Barthel L, Hadamitzky M et. al.

Oct 24th, 2021 - In patients with glioblastoma, the average survival time with current treatments is short, mainly due to recurrences and resistance to therapy. This insufficient treatment success is, in large parts, due to the tremendous molecular heterogeneity of gliomas, which affects the overall prognosis and response to therapies and plays a vital role in gliomas' grading. In addition, the tumor microenvir...

Proteomics analysis reveals digestion-resistant proteins from colostrum are associated ...
https://doi.org/10.1002/jpen.2285
JPEN. Journal of ParEnteral and Enteral Nutrition; Chen Y, Kim BJ et. al.

Oct 24th, 2021 - Though human milk feeding reduces the risk of necrotizing enterocolitis (NEC) in preterm infants compared with formula feeding, the exact risk reduction mechanism remains unknown. As NEC occurs at the distal small intestines where digestion has occurred, we applied proteomics to examine the extent to which colostrum proteins survive simulated infant in vitro digestion, and thus have potential t...

In vitro and in vivo therapeutic potentials of 6-gingerol in combination with amphoteri...
https://doi.org/10.1016/j.intimp.2021.108274
International Immunopharmacology; Keyhani A, Sharifi I et. al.

Oct 24th, 2021 - The ongoing conventional drugs for leishmaniasis treatment are insufficient. The present study aimed to assess 6-gingerol alone and in combination with amphotericin B on Leishmania major stages using experimental and in vivo murine models. Here, arrays of experimental approaches were designed to monitor and evaluate the 6-gingerol potential therapeutic outcomes. The binding affinity of 6-ginger...

Loss of Endothelial TSPAN12 Promotes Fibrostenotic Eosinophilic Esophagitis via Endothe...
https://doi.org/10.1053/j.gastro.2021.10.016
Gastroenterology Shoda T, Wen T et. al.

Oct 24th, 2021 - Eosinophilic esophagitis (EoE) can progress to fibrostenosis by unclear mechanisms. Herein, we investigated gene dysregulation in fibrostenotic EoE, its association with clinical parameters and specific pathways, and the functional consequences. Esophageal biopsies from subjects with EoE were collected across 11 Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) sites (n = ...

PLCγ1/PKCθ Downstream Signaling Controls Cutaneous T-Cell Lymphoma Development And Prog...
https://doi.org/10.1016/j.jid.2021.09.024
The Journal of Investigative Dermatology; García-Díaz N, Casar B et. al.

Oct 24th, 2021 - Developing mechanistic rationales can improve the clinical management of cutaneous T-cell lymphomas (CTCL). There is considerable genetic and biological evidence of a malignant network of signaling mechanisms, highly influenced by deregulated TCR/PLCγ1 activity, controlling the biology of these lesions. In addition, activated STAT3 is associated with clinical progression, although the alteratio...

Therapeutic antibodies - natural and pathological barriers and strategies to overcome t...
https://doi.org/10.1016/j.pharmthera.2021.108022
Pharmacology & Therapeutics; Al Ojaimi Y, Blin T et. al.

Oct 24th, 2021 - Antibody-based therapeutics have become a major class of therapeutics with over 120 recombinant antibodies approved or under review in the EU or US. This therapeutic class has experienced a remarkable expansion with an expected acceleration in 2021-2022 due to the extraordinary global response to SARS-CoV2 pandemic and the public disclosure of over a hundred anti-SARS-CoV2 antibodies. Mainly de...

Prolonged sub-lethal exposure to galaxolide (HHCB) and tonalide (AHTN) promotes the met...
https://doi.org/10.1016/j.neuro.2021.10.006
Neurotoxicology Doğanlar O, Doğanlar ZB et. al.

Oct 24th, 2021 - Galaxolide and tonalide are well-known polycyclic musks whose intensive use without limitations in numerous cleaning, hygiene, and personal care products has resulted in widespread direct human exposure via absorption, inhalation, and oral ingestion. Latest data shows that long-term, low-dose exposure to toxic chemicals can induce unpredictable harmful effects in a variety of living systems, ho...

Molecular signature of brain arteriovenous malformation hemorrhage: a systematic review.
https://doi.org/10.1016/j.wneu.2021.10.114
World Neurosurgery; Germans MR, Sun W et. al.

Oct 24th, 2021 - The mechanisms of brain arteriovenous malformation (bAVM) development, formation and progress are still poorly understood. By gaining more knowledge about the molecular signature of bAVM in relation to hemorrhage, we might be able to find biomarkers associated with this serious complication, which can function as a goal for further research and can be a potential target for gene therapy. To pro...

Myeloid lineage contributes to pathological choroidal neovascularization formation via ...
https://doi.org/10.1016/j.ebiom.2021.103632
EBioMedicine Wang T, Zhou P et. al.

Oct 24th, 2021 - Pathological neovascularization in neovascular age-related macular degeneration (nAMD) is the leading cause of vision loss in the elderly. Increasing evidence shows that cells of myeloid lineage play important roles in controlling pathological endothelium formation. Suppressor of cytokine signaling 3 (SOCS3) pathway has been linked to neovascularization. We utilised a laser-induced choroidal ne...

Assessment and Management of Loose Bodies in the Knee Joint and Related Disease: A Narr...
https://doi.org/10.2174/1573397117666211021165807
Current Rheumatology Reviews; Zmerly H, Moscato M et. al.

Oct 23rd, 2021 - Loose bodies are frequently encountered during clinical activity and a common finding during knee arthroscopy. Usually, treatment consists of the removal of the loose bodies, which can be challenging even for experienced surgeons. The excision alone is not always the complete treatment, because loose bodies are generally secondary to other diseases that can cause persistent symptoms with the ri...