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About 186,705 results

Fluconazole - fluconazole tablet-REMEDYREPACK INC.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d11e0926-cd15-49ba-b0ee-2b6d4e009dd8

Dec 30th, 2022 - Fluconazole tablets are indicated for the treatment of: Vaginal candidiasis (vaginal yeast infections due to Candida). Oropharyngeal and esophageal candidiasis. In open noncomparative studies of relatively small numbers of patients, fluconazole tablets were also effective for the treatment of Candida urinary tract infections, peritonitis, and systemic Candida infections including candidemia, di...

Bimatoprost - bimatoprost solution/ drops-Lupin Pharmaceuticals, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ac853f64-50bd-4bff-9cbe-aac93ef5550f

Jul 1st, 2022 - Bimatoprost ophthalmic solution, 0.03% is a prostaglandin analog indicated for the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension. (1) Bimatoprost ophthalmic solution, 0.03% is indicated for the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension.

SARS-CoV-2 is associated with changes in brain structure in UK Biobank
https://www.nature.com/articles/s41586-022-04569-5
Nature Douaud G, .

Mar 7th, 2022 - There is strong evidence for brain-related abnormalities in COVID-191–13. It remains unknown however whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing to brain pathology. Here, we investigated brain changes in 785 UK Biobank participants (aged 51–81) imaged twice, including 401 cases who tested positive for i...

Moxifloxacin - moxifloxacin solution/ drops-Lupin Pharmaceuticals, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ae77e219-8af9-4aa4-96d3-05c9726a1d3c

Jun 6th, 2022 - Moxifloxacin ophthalmic solution, 0.5% is a topical fluoroquinolone anti- infective indicated for the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: Corynebacterium species*, Micrococcus luteus*, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus warneri*, Streptococcus pneumonia...

Quetiapine fumarate - quetiapine fumarate tablet, extended release-Lupin Pharmaceuticals, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7803a290-91c0-4e7f-90b5-d2ff33a46cee

Jun 1st, 2022 - Quetiapine extended-release tablet is an atypical antipsychotic indicated for the treatment of: Schizophrenia (1.1) Bipolar I disorder, manic or mixed episodes (1.2) Bipolar disorder, depressive episodes (1.2) Major depressive disorder, adjunctive therapy with antidepressants (1.3) Quetiapine extended-release tablet is indicated for the treatment of schizophrenia. The efficacy of quetiapine ext...

Imatinib mesylate - imatinib mesylate tablet, film coated-Apotex Corp
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0291eca5-7a1d-4a79-30be-252224d96509

May 30th, 2022 - Imatinib mesylate is a kinase inhibitor indicated for the treatment of: • Newly diagnosed adult and pediatric patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase (1.1) • Patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in blast crisis (BC), accelerated phase (AP), or in chronic phase (CP) after failure of interferon...

Evaluating fostamatinib disodium as a treatment option for immune thrombocytopenia in a...
https://doi.org/10.1080/14656566.2022.2082283
Expert Opinion on Pharmacotherapy; Dierickx D, Neefs J

May 28th, 2022 - Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by increased platelet destruction and decreased platelet production, leading to thrombocytopenia with or without bleeding manifestations. The majority of patients experiencing treatment need will eventually need secondary treatment following first line therapy with steroids. In 2018, the oral spleen tyrosine kinase i...

A Mechanistic Insight into the Pathogenic Role of Interleukin 17A in Systemic Autoimmun...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129985
Mediators of Inflammation; Bisoendial R, Lubberts E

May 28th, 2022 - Interleukin 17A (IL-17A) has been put forward as a strong ally in our fight against invading pathogens across exposed epithelial surfaces by serving an antimicrobial immunosurveillance role in these tissues to protect the barrier integrity. Amongst other mechanisms that prevent tissue injury mediated by potential microbial threats and promote restoration of epithelial homeostasis, IL-17A attrac...

Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for...
https://doi.org/10.1080/22221751.2022.2081619
Emerging Microbes & Infections; Li H, Han X et. al.

May 28th, 2022 - Cryptococcal meningoencephalitis (CM) is emerging as an infection in HIV/AIDS patients shifted from primarily ART- naive to ART-experienced individuals, as well as patients with COVID-19 and immunocompetent hosts. This fungal infection is mainly caused by the opportunistic human pathogen Cryptococcus neoformans. Brain or central nervous system (CNS) dissemination is the deadliest process for th...

Distinct morphology of cardiac- and brown adipose tissue-projecting neurons in the stel...
https://doi.org/10.14814/phy2.15334
Physiological Reports; Barrett MS, Hegarty DM et. al.

May 28th, 2022 - Sympathetic neurons that innervate the heart are located primarily in the stellate ganglia (SG), which also contains neurons that project to brown adipose tissue (BAT). These studies were designed to examine the morphology of these two populations (cardiac- and BAT-projecting) and their target connectivity. We examined SG neurons in C57BL/6J mice following injections of the retrograde tracer ch...

The Role of Microorganisms in Appendiceal Pseudomyxoma Peritonei: A Review.
https://doi.org/10.3390/curroncol29050289
Current Oncology (Toronto, Ont.); Khamzina Y, King MC et. al.

May 28th, 2022 - Pseudomyxoma peritonei (PMP) is a rare clinical syndrome. It originates from neoplasms of the appendix and leads to the formation of peritoneal implants and the accumulation of mucinous ascites. PMP represents a spectrum of low to high-grade disease. Despite aggressive management, many PMP patients recur, leading to debilitating symptoms and few treatment options. Therefore, scientists have con...

CAR T Cell Therapy for Chronic Lymphocytic Leukemia: Successes and Shortcomings.
https://doi.org/10.3390/curroncol29050293
Current Oncology (Toronto, Ont.); Todorovic Z, Todorovic D et. al.

May 28th, 2022 - Chimeric antigen receptor T (CAR T) cell therapy achieved remarkable success in B-cell leukemia and lymphoma which led to its incorporation in treatment protocols for these diseases. CAR T cell therapy for chronic lymphocytic leukemia (CLL) patients showed less success compared to other malignant tumors. In this review, we discuss the published results regarding CAR T cell therapy of CLL, possi...

Nucleophosmin 1: from its pathogenic role to a tantalizing therapeutic target in acute ...
https://doi.org/10.1080/16078454.2022.2067939
Hematology (Amsterdam, Netherlands); Shi Y, Xue Y et. al.

May 28th, 2022 - Nucleophosmin 1 (NPM1, also known as B23) is a multifunctional protein involved in a variety of cellular processes, including ribosomal maturation, centrosome replication, maintenance of genomic stability, cell cycle control, and apoptosis. NPM1 is the most commonly mutated gene in adult acute myeloid leukemia (AML) and is present in approximately 40% of all AML cases. The underlying mechanisms...

A Review of Disease Mechanisms and Current and Emerging Treatment Options for Generaliz...
https://doi.org/10.4088/PCC.AR21018WC2C
The Primary Care Companion for CNS Disorders; Bril V, Silvestri NJ et. al.

May 28th, 2022 - Generalized myasthenia gravis (gMG) is a disease resulting from impaired neuromuscular transmission due to presence of antibodies that block acetylcholine receptors. Autoantibodies to acetylcholine receptors directly impair the activity of ion channels that conduct nerve impulses, and cross-link acetylcholine receptors resulting in complement-mediated destruction, further worsening functional i...

Identification of a Germline Pyrin Variant in a Metastatic Melanoma Patient With Multip...
https://doi.org/10.1097/CJI.0000000000000425
Journal of Immunotherapy (Hagerstown, Md. : 1997); Oswalt CJ, Al-Rohil RN et. al.

May 28th, 2022 - The mechanisms underlying tumor immunosurveillance and their association with the immune-related adverse events (irAEs) associated with checkpoint inhibitor immunotherapies remain poorly understood. We describe a metastatic melanoma patient exhibiting multiple episodes of spontaneous disease regression followed by the development of several irAEs during the course of anti-programmed cell death ...

Expression analysis of mTOR-associated lncRNAs in multiple sclerosis.
https://doi.org/10.1007/s11011-022-01010-8 10.1186/s43042-022-00260-6 10.2217/imt.14.84 10.1016/j.fitote.2016.11.010 10.2147/OTT.S252750 10.1016/j.jbior.2017.06.003 10.1016/j.jbior.2016.12.001 10.1042/BSR20192598 10.3109/08830185.2014.933957 10.1111/jcmm.13420 10.18632/oncotarget.23862 10.3389/fimmu.2020.590870 10.1002/ana.22366 10.1007/s12031-020-01628-2 10.4049/jimmunol.1701477 10.1002/jcp.28767 10.1080/09168451.2014.998617
Metabolic Brain Disease; Akbari M, Eshghyar F et. al.

May 28th, 2022 - mTOR has been shown to be involved in the regulation of immune responses and differentiation of immune cells. This protein is a candidate molecule for unraveling the molecular mechanisms of autoimmune disorders such as multiple sclerosis (MS). We designed the current study to assess expression of MTOR, and four associated long non-coding RNAs (lncRNAs), namely SNHG1, SNHG3, SHNG5 and DANCR in t...

Induction Study #2 of Oral Ozanimod as Induction Therapy for Moderately to Severely Active Crohn's Disease
https://clinicaltrials.gov/ct2/show/NCT03440385

May 27th, 2022 - This is a study to explore the effect of oral ozanimod as an induction treatment for participants with moderately to severely active Crohn's Disease.

Chronic Myelogenous Leukemia (CML) Medication
http://emedicine.medscape.com/article/199425-medication

May 27th, 2022 - Medication Summary The medications used for patients with chronic-phase chronic myelogenous leukemia (CML) aim at delaying the onset of the accelerated or blastic phase. This has traditionally included a myelosuppressive agent to achieve hematologic remission, but more effective drugs—successively, interferon alfa, then targeted therapy with tyrosine kinase inhibitors such as imatinib mesylate—...

Olaparib (LYNPARZA) Plus Durvalumab (IMFINZI) in EGFR-Mutated Adenocarcinomas That Transform to Small Cell Lung Cancer (SCLC) and Other Neuroendocrine Tumors
https://clinicaltrials.gov/ct2/show/NCT04538378

May 27th, 2022 - Background: Targeted therapies designed for specific genetic alterations, known as cancer driver mutations, have changed the treatment paradigm in advanced non-small cell lung carcinoma (NSCLC). Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are effective in NSCLC with activating mutation in the EGFR. Although most patients achieve robust responses to EGFR TKIs with t...

Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy
https://clinicaltrials.gov/ct2/show/NCT00977977

May 27th, 2022 - This is a pilot intervention study to evaluate preliminary evidence of the safety and effectiveness of a novel combination immunosuppressive regimen, Rituximab plus cyclosporine, in the treatment of idiopathic membranous nephropathy. Membranous nephropathy is a condition that affects the kidney and involves damage to the walls of tiny blood vessels filters in the kidneys called glomeruli. This ...