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About 251,748 results

Natural History and Development of Spondyloarthritis
https://clinicaltrials.gov/ct2/show/NCT01422694

Jan 13th, 2023 - The purpose of this protocol is to study the natural history of spondyloarthritis (SpA) in children and adults. Spondyloarthritis encompasses a spectrum of immune-mediated inflammatory diseases that exhibit overlapping features, but differ from other types of inflammatory arthritis in genetic predisposition, pathogenesis, and outcome. Ankylosing spondylitis (AS), the most common form of SpA, fr...

JAK Inhibitor Improves Symptoms, Anemia in Myelofibrosis
https://www.medpagetoday.com/hematologyoncology/othercancers/102883

Jan 30th, 2023 - Myelofibrosis treatment with the Janus kinase (JAK) inhibitor momelotinib resulted in clinically significant improvements in symptoms and spleen response compared with danazol for symptomatic, JAK inhibitor-exposed patients with anemia and intermediate- or high-risk disease, the phase III MOMENTUM trial showed. A significantly greater proportion of patients in the momelotinib group reported a ≥...

Exaggerated levels of some specific TLRs, cytokines and chemokines in Japanese encephal...
https://doi.org/10.1186/s12985-023-01966-8
Virology Journal; Shukla M, Garg A et. al.

Jan 29th, 2023 - Japanese encephalitis (JE) disease, a viral brain fever is caused by Japanese encephalitis virus (JEV). Despite the availability of effective vaccines against this deadly infection, JE is the leading cause of epidemic viral encephalitis in children in South-east Asia. There is no treatment available for the JE disease which might be due to incomplete understanding of the pathogenesis of JE viru...

Preclinical pharmacokinetics and tolerability of a novel meglumine-based parenteral sol...
https://doi.org/10.1111/epi.17520
Epilepsia Rundfeldt C, Klein P et. al.

Jan 29th, 2023 - For an anti-seizure medication (ASM) to be effective in status epilepticus (SE), the drug should be administered intravenously (i.v.) to provide quick access to the brain. However, poor aqueous solubility is a major problem in the development of parenteral drug solutions. Given its multiple mechanisms of action, topiramate (TPM) is a promising candidate for the treatment of established or refra...

Drug-drug interactions associated with FLT3 inhibitors for acute myeloblastic leukemia:...
https://doi.org/10.1080/17512433.2023.2174523
Expert Review of Clinical Pharmacology; Solana-Altabella A, Megías-Vericat JE et. al.

Jan 29th, 2023 - FLT3 inhibitors (FLT3i) are drugs in which there is limited experience and not yet enough information on the mechanisms of absorption, transport, and elimination; but especially on the potential drug-drug interactions (DDIs). There are therefore risks in the management of FLT3i DDIs (i.e., sorafenib, ponatinib, crenolanib, midostaurin, quizartinib, and gilteritinib) and ignoring them can compro...

Iron chelation therapy.
https://doi.org/10.1111/ejh.13935
European Journal of Haematology; Bruzzese A, Martino EA et. al.

Jan 29th, 2023 - Iron overload is a pathological condition resulting from a congenital impairment of its regulation, increased intestinal iron absorption secondary to bone marrow erythroid hyperplasia, or a chronic transfusional regimen. In normal conditions, intracellular and systemic mechanisms contribute to maintaining iron balance. When this complex homeostatic mechanism fails, an iron overload could be pre...

Omaveloxolone: An activator of Nrf2 for the treatment of Friedreich's ataxia.
https://doi.org/10.1080/13543784.2023.2173063
Expert Opinion on Investigational Drugs; Profeta V, McIntyre K et. al.

Jan 29th, 2023 - Friedreich ataxia (FRDA) is a rare autosomal recessive degenerative disorder characterized by ataxia, dysarthria, diabetes, cardiomyopathy, scoliosis, and occasionally vision loss in late-stage disease. The discovery of the abnormal gene in FRDA and its product frataxin has provided insight into the pathophysiology and mechanisms of treatment. Although the neurologic phenotype of FRDA is well-d...

PROGRESSION OF VASCULAR FUNCTION AND BLOOD PRESSURE IN A MOUSE MODEL OF KAWASAKI DISEASE.
https://doi.org/10.1097/SHK.0000000000002026
Shock (Augusta, Ga.); DelVechio M, Alves JV et. al.

Jan 28th, 2023 - Kawasaki disease (KD) is a systemic vasculitis of childhood characterized by vascular damage in the acute stage, which can persist into the late stage. The vascular mechanisms in the cardiovascular risk of KD are not fully studied. We investigated the vascular function and blood pressure in a murine model of KD. We used the Candida albicans water-soluble (CAWS) fraction model. Mice were injecte...

Herpetic Eye Disease After SARS-CoV-2 Vaccination: A CDC-VAERS Database Analysis.
https://doi.org/10.1097/ICO.0000000000003246
Cornea Singh RB, Parmar UPS et. al.

Jan 28th, 2023 - The aim of this study was to evaluate the cases of herpes simplex and zoster ophthalmicus after SARS-CoV-2 vaccination and assess the clinical presentations in patients. A retrospective analysis of cases reported to the Centers for Disease Control and Prevention (CDC) Vaccine Adverse Event Reporting System (VAERS) between December 11, 2020, and July 1, 2022. Patients diagnosed with herpes simpl...

The temporal characteristics of the disruption of gut microbiota, serum metabolome, and...
https://doi.org/10.1016/j.ecoenv.2023.114580
Ecotoxicology and Environmental Safety; Guo J, Zhang B et. al.

Jan 28th, 2023 - Silicosis is one of the most frequent, rapidly developing, and lethal types of pneumoconiosis. However, our understanding of the underlying mechanisms of its pathogenesis and progress remains unclear. We investigated the fundamental processes of silicosis incidence and progression using a combination of lung function testing, histopathology, 16 S rRNA, untargeted metabolomics, and cytokine chip...

Mechanisms of Thrombosis in Heparin-Induced Thrombocytopenia and Vaccine-Induced Immune...
https://doi.org/10.1055/s-0043-1761269
Seminars in Thrombosis and Hemostasis; Selvadurai MV, Favaloro EJ et. al.

Jan 28th, 2023 - Heparin-induced thrombocytopenia (HIT) and vaccine-induced immune thrombotic thrombocytopenia (VITT) are rare, iatrogenic immune-mediated conditions with high rates of thrombosis-related morbidity and mortality. HIT is a long-recognized reaction to the administration of the common parenterally administered anticoagulant heparin (or its derivatives), while VITT is a new, distinct syndrome occurr...

Curcumol suppresses endothelial-to-mesenchymal transition via inhibiting the AKT/GSK3β ...
https://doi.org/10.1016/j.ejphar.2023.175546
European Journal of Pharmacology; Nie X, Wu Z et. al.

Jan 28th, 2023 - Endothelial dysfunction is essential in pulmonary arterial hypertension (PAH) pathogenesis and is considered to be a therapeutic target of PAH. Curcumol is a bioactive sesquiterpenoid with pharmacological properties including restoring endothelial cells damage. This study aimed to evaluate the effect of curcumol on PAH rats and investigate its possible mechanisms. PAH was induced by subcutaneou...

Mechanistic insights into the conformational switch in profilin-1 subject to collective...
https://doi.org/10.1016/j.ijbiomac.2023.123403
International Journal of Biological Macromolecules; Muneeswaran G, Lee JY

Jan 28th, 2023 - Mutations and histidine (His) tautomerism in profilin-1 (PFN1) are associated with amyotrophic lateral sclerosis (ALS). The conformational changes in PFN1 caused by the collective effects of G117V mutation and His tautomeric isomers εε, εδ, δε, and δδ were clarified using molecular dynamics (MD) simulations. The predominant structural variations were seen in α-helices, β-sheets, turns, and coil...

Gymnadenia conopsea (L.) R. Br.: Comprehensive review of propagation and breeding, trad...
https://doi.org/10.1016/j.jep.2023.116205
Journal of Ethnopharmacology; Meng XH, Wang M et. al.

Jan 28th, 2023 - Gymnadenia conopsea, a perennial herbaceous flowering plant that belongs to the family of Orchidaceae, sporadic distributed in the altitudes of 200-4700 m across northern Europe and, temperate and subtropical Asia region. The dried tubers of G. conopsea have been used to treat cough, asthma, and their syndromes, and also as a tonic in China and surrounding countries for a long history. G. conop...

Cellular senescence in malignant cells promotes tumor progression in mouse and patient ...
https://doi.org/10.1038/s41467-023-36124-9
Nature Communications; Salam R, Saliou A et. al.

Jan 28th, 2023 - Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, yet it remains refractory to systemic therapy. Elimination of senescent cells has emerged as a promising new treatment approach against cancer. Here, we investigated the contribution of senescent cells to GBM progression. Senescent cells are identified in patient and mouse GBMs. Partial removal of p16Ink4a-expressing...

Conformational state of C-reactive protein is critical for reducing immune complex-trig...
https://doi.org/10.1016/j.jaut.2023.102998
Journal of Autoimmunity; Svanberg C, Enocsson H et. al.

Jan 28th, 2023 - Presence of autoantibodies targeting nuclear constituents, i.e., double-stranded DNA and small nuclear ribonucleoproteins (snRNPs), remain a cornerstone in systemic lupus erythematosus (SLE). Fcγ receptor IIa (FcγRIIa) dependent uptake of nucleic acid containing immune complexes (ICs) by plasmacytoid dendritic cells (PDCs) can activate toll-like receptors (TLRs) such as TLR7 and TLR9 resulting ...

Efficacy of pyriproxyfen-pyrethroid long-lasting insecticidal nets (LLINs) and chlorfen...
https://doi.org/10.1016/S0140-6736(22)02319-4
Lancet (London, England); Accrombessi M, Cook J et. al.

Jan 28th, 2023 - New classes of long-lasting insecticidal nets (LLINs) combining mixtures of insecticides with different modes of action could put malaria control back on track after rebounds in transmission across sub-Saharan Africa. We evaluated the relative efficacy of pyriproxyfen-pyrethroid LLINs and chlorfenapyr-pyrethroid LLINs compared with standard LLINs against malaria transmission in an area of high ...

Use of lithium in pediatric bipolar disorders and externalizing childhood- related diso...
https://doi.org/10.2174/1570159X21666230126153105
Current Neuropharmacology; Janiri D, Moccia L et. al.

Jan 28th, 2023 - Lithium is the standard treatment for bipolar disorders (BD) in adults. There is dearth of data on its use in pediatric age. This review aimed to investigate the use of lithium in pediatric bipolar disorder (BD) and other externalizing childhood-related disorders. We applied the Preferred Reporting Items for Systematic Reviews and Meta- analyses criteria (PRISMA) to identify randomized controll...

Blood-CNS barrier dysfunction in amyotrophic lateral sclerosis: Proposed mechanisms and...
https://doi.org/10.1177/0271678X231153281
Journal of Cerebral Blood Flow and Metabolism : Official ... Steinruecke M, Lonergan RM et. al.

Jan 28th, 2023 - There is strong evidence for blood-brain and blood-spinal cord barrier dysfunction at the early stages of many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Since impairment of the blood-central nervous system barrier (BCNSB) occurs during the pre-symptomatic stages of ALS, the mechanisms underlying this pathology are likely also involved in the ALS disease process....

Ethanol potentiates FSH action in ovarian granulosa cells.
https://doi.org/10.1530/JOE-22-0254
The Journal of Endocrinology; Kasahara Y, Kishi H et. al.

Jan 28th, 2023 - There are many previous reports on the effects of ethanol on physiological function, including reports of elevated blood estrogen levels in women who drank alcohol. However, the mechanism of ethanol's effects on ovarian functions, such as follicle development and hormone secretion, hasn't been fully clarified. Therefore, in this study, we investigated the impacts of ethanol on these phenomena a...