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About 100,268 results

Risk factors and outcomes for acute respiratory failure in coronavirus disease 2019: An...
https://doi.org/10.17219/acem/130603
Advances in Clinical and Experimental Medicine : Official... Piwowarczyk P, Szczukocka M et. al.

Dec 31st, 2020 - The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread throughout Europe. However, there is a lack of data on the full clinical course of patients infected with SARS-CoV-2 in Europe, especially in the population that developed acute respiratory failure (ARF). To identify risk factors associated with developing ARF during SARS-CoV-2 infection. This was an observationa...

Event-free survival at 24 months is a robust end point for disease-related outcome in d...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965261
Journal of Clinical Oncology : Official Journal of the Am... Maurer MJ, Ghesquières H et. al.

Feb 19th, 2014 - Studies of diffuse large B-cell lymphoma (DLBCL) are typically evaluated by using a time-to-event approach with relapse, re-treatment, and death commonly used as the events. We evaluated the timing and type of events in newly diagnosed DLBCL and compared patient outcome with reference population data. Patients with newly diagnosed DLBCL treated with immunochemotherapy were prospectively enrolle...

Rosuvastatin for sepsis-associated acute respiratory distress syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241052
The New England Journal of Medicine; , Truwit JD et. al.

May 19th, 2014 - In the acute respiratory distress syndrome (ARDS), inflammation in the lungs and other organs can cause life-threatening organ failure. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) can modulate inflammatory responses. Previous observational studies suggested that statins improved clinical outcomes in patients with sepsis. We hypothesized that rosuvastatin therapy woul...

Screening for abdominal aortic aneurysm: U.S. Preventive Services Task Force recommenda...
https://doi.org/10.7326/M14-1204
Annals of Internal Medicine; LeFevre ML,

Jun 24th, 2014 - Update of the 2005 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for abdominal aortic aneurysm (AAA). The USPSTF commissioned a systematic review that assessed the evidence on the benefits and harms of screening for AAA and strategies for managing small (3.0 to 5.4 cm) screen-detected AAAs. These recommendations apply to asymptomatic adults aged 50 years or older. The...

Nonselective β blockers increase risk for hepatorenal syndrome and death in patients wi...
https://doi.org/10.1053/j.gastro.2014.03.005
Gastroenterology Mandorfer M, Bota S et. al.

Mar 18th, 2014 - Nonselective β blockers (NSBBs) reduce portal pressure and the risk for variceal hemorrhage in patients with cirrhosis. However, development of spontaneous bacterial peritonitis (SBP) in these patients could preclude treatment with NSBBs because of their effects on the circulatory reserve. We investigated the effects of NSBBs in patients with cirrhosis and ascites with and without SBP. We perfo...

Clinical picture and treatment of 2212 patients with common variable immunodeficiency.
https://doi.org/10.1016/j.jaci.2013.12.1077
The Journal of Allergy and Clinical Immunology; Gathmann B, Mahlaoui N et. al.

Mar 3rd, 2014 - Common variable immunodeficiency (CVID) is an antibody deficiency with an equal sex distribution and a high variability in clinical presentation. The main features include respiratory tract infections and their associated complications, enteropathy, autoimmunity, and lymphoproliferative disorders. This study analyzes the clinical presentation, association between clinical features, and differen...

Transplantation outcomes for severe combined immunodeficiency, 2000-2009.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183064
The New England Journal of Medicine; Pai SY, Logan BR et. al.

Jul 30th, 2014 - The Primary Immune Deficiency Treatment Consortium was formed to analyze the results of hematopoietic-cell transplantation in children with severe combined immunodeficiency (SCID) and other primary immunodeficiencies. Factors associated with a good transplantation outcome need to be identified in order to design safer and more effective curative therapy, particularly for children with SCID diag...

Multidrug-resistant tuberculosis and culture conversion with bedaquiline.
https://doi.org/10.1056/NEJMoa1313865
The New England Journal of Medicine; Diacon AH, Pym A et. al.

Aug 20th, 2014 - Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with accelerated sputum-culture conversion in patients with multidrug-resistant tuberculosis, when added to a preferred background regimen for 8 weeks. In this phase 2b trial, we randomly assigned 160 patients with newly diagnosed, smear-positive, multidrug-resistant tuberculosis to re...

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900
The New England Journal of Medicine; Roberts KG, Li Y et. al.

Sep 10th, 2014 - Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and ad...

Surveillance for stage I nonseminoma testicular cancer: outcomes and long-term follow-u...
https://doi.org/10.1200/JCO.2013.53.5831
Journal of Clinical Oncology : Official Journal of the Am... Daugaard G, Gundgaard MG et. al.

Sep 30th, 2014 - To describe treatment results in a large cohort with stage I nonseminoma germ cell cancer (NSGCC) treated in a surveillance program. From January 1, 1984, to December 31, 2007, 1,226 patients with stage I NSGCC, including high-risk patients with vascular invasion, were observed in a surveillance program. The relapse rate after orchiectomy alone was 30.6% at 5 years. Presence of vascular invasio...

Chimeric antigen receptor T cells for sustained remissions in leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267531
The New England Journal of Medicine; Maude SL, Frey N et. al.

Oct 15th, 2014 - Relapsed acute lymphoblastic leukemia (ALL) is difficult to treat despite the availability of aggressive therapies. Chimeric antigen receptor-modified T cells targeting CD19 may overcome many limitations of conventional therapies and induce remission in patients with refractory disease. We infused autologous T cells transduced with a CD19-directed chimeric antigen receptor (CTL019) lentiviral v...

Autologous transplantation and maintenance therapy in multiple myeloma.
https://doi.org/10.1056/NEJMoa1402888
The New England Journal of Medicine; Palumbo A, Cavallo F et. al.

Sep 3rd, 2014 - This open-label, randomized, phase 3 study compared melphalan at a dose of 200 mg per square meter of body-surface area plus autologous stem-cell transplantation with melphalan-prednisone-lenalidomide (MPR) and compared lenalidomide maintenance therapy with no maintenance therapy in patients with newly diagnosed multiple myeloma. We randomly assigned 273 patients 65 years of age or younger to h...

Stereotactic body radiotherapy vs. TACE or RFA as a bridge to transplant in patients wi...
https://doi.org/10.1016/j.jhep.2017.02.022
Journal of Hepatology; Sapisochin G, Barry A et. al.

Mar 4th, 2017 - There is limited information on the use of stereotactic body radiotherapy (SBRT) as a bridge to liver transplantation for hepatocellular carcinoma and no study comparing its efficacy to transarterial chemoembolization (TACE) and radiofrequency ablation (RFA). We aimed to ascertain the safety and efficacy of SBRT on an intention-to-treat basis compared with TACE and RFA as a bridge to liver tran...

Association of hospital structures with mortality from ruptured abdominal aortic aneurysm.
https://doi.org/10.1002/bjs.9759
The British Journal of Surgery; Ozdemir BA, Karthikesalingam A et. al.

Feb 23rd, 2015 - There is significant variation in the mortality rates of patients with a ruptured abdominal aortic aneurysm (rAAA) admitted to hospital in England. This study sought to investigate whether modifiable differences in hospital structures and processes were associated with differences in patient outcome. Patients diagnosed with rAAA between 2005 and 2010 were extracted from the Hospital Episode Sta...

Long-term outcomes of pediatric living donor liver transplantation at a single institut...
https://doi.org/10.1111/j.1399-3046.2010.01357.x
Pediatric Transplantation; Oh SH, Kim KM et. al.

Jul 8th, 2010 - There have only been a few studies on the long-term outcomes and prognostic factors after pediatric LDLT. We conducted a retrospective, single-center assessment of the outcomes as well as the demographic and clinical factors that influenced the poor outcomes in 113 children aged <16 (median age 21 months; 6 months-15.5 yr) who underwent 115 LDLTs, predominantly for biliary atresia (60.9%) and F...

The natural history of multiple system atrophy: a prospective European cohort study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581815
The Lancet. Neurology; Wenning GK, Geser F et. al.

Feb 8th, 2013 - Multiple system atrophy (MSA) is a fatal and still poorly understood degenerative movement disorder that is characterised by autonomic failure, cerebellar ataxia, and parkinsonism in various combinations. Here we present the final analysis of a prospective multicentre study by the European MSA Study Group to investigate the natural history of MSA. Patients with a clinical diagnosis of MSA were ...

Local control of metastatic sites with radiation therapy in metastatic Ewing sarcoma an...
https://doi.org/10.1002/pbc.23063
Pediatric Blood & Cancer; Liu AK, Stinauer M et. al.

May 10th, 2011 - Approximately 20% of children with Ewing sarcoma (EWS) and rhabdomyosarcoma (RMS) present with metastatic disease at initial diagnosis. Overall, the outcome is poor, with an event-free survival of < 20%. Local control at metastatic sites has not been previously reported. We reviewed control of metastatic sites in children with EWS and RMS that received curative intent radiation therapy to each ...

Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631139
The New England Journal of Medicine; Von Hoff DD, Ervin T et. al.

Oct 17th, 2013 - In a phase 1-2 trial of albumin-bound paclitaxel (nab-paclitaxel) plus gemcitabine, substantial clinical activity was noted in patients with advanced pancreatic cancer. We conducted a phase 3 study of the efficacy and safety of the combination versus gemcitabine monotherapy in patients with metastatic pancreatic cancer. We randomly assigned patients with a Karnofsky performance-status score of ...

4-year results of a randomized controlled trial of percutaneous repair versus surgery f...
https://doi.org/10.1016/j.jacc.2013.04.030
Journal of the American College of Cardiology; Mauri L, Foster E et. al.

May 14th, 2013 - This study sought to evaluate 4-year outcomes of percutaneous repair versus surgery for mitral regurgitation. Transcatheter therapies are being developed to treat valvular heart disease. In the EVEREST (Endovascular Valve Edge-to-Edge Repair Study) II trial, treatment of mitral valve regurgitation (MR) with a novel percutaneous device was compared with surgery and showed superior safety, but le...

Diabetes before and after lung transplantation in patients with cystic fibrosis and oth...
https://doi.org/10.1111/j.1464-5491.2012.03676.x
Diabetic Medicine : a Journal of the British Diabetic Ass... Belle-van Meerkerk G, van de Graaf EA et. al.

Apr 10th, 2012 - The aims of the study are to investigate the prevalence of diabetes in patients with cystic fibrosis compared with patients without cystic fibrosis, and its impact on the outcome after lung transplantation. Data were reviewed from 77 lung transplantation recipients in our centre between 2001 and 2010; 43 patients had cystic fibrosis and 34 patients had other lung diseases (no cystic fibrosis). ...