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VIDEO: Striving for ‘one and done’ with collagen cross-linking
https://www.healio.com/news/ophthalmology/20220126/video-striving-for-one-and-done-with-collagen-crosslinking

Jan 26th, 2022 - WAIKOLOA, Hawaii — In this Healio Video Perspective from Hawaiian Eye 2022, Kathryn M. Hatch, MD, explains why cornea specialists strive for “one and done” when treating keratoconus and other epithelial defects with collagen cross-linking.

Consensus group provides imaging criteria for assessment of geographic atrophy
https://www.healio.com/news/ophthalmology/20220119/consensus-group-provides-imaging-criteria-for-assessment-of-geographic-atrophy

Jan 19th, 2022 - WAIKOLOA, Hawaii — In a series of published reports, the Classification of Atrophy Meeting group provided consensus-based imaging parameters for multimodal assessment of geographic atrophy. The group also revised the definitions of specific features of geographic atrophy (GA) and identified features that may predict progression to atrophy. “In the first CAM report, we described the imaging moda...

Address ocular surface disease before surgery to optimize patient satisfaction
https://www.healio.com/news/ophthalmology/20220117/address-ocular-surface-disease-before-surgery-to-optimize-patient-satisfaction

Jan 17th, 2022 - WAIKOLOA, Hawaii — Diagnosing and treating ocular surface disease preoperatively is one of the elements that contribute to elevated patient satisfaction postoperatively, Marjan Farid, MD, said at Hawaiian Eye 2022. “We know that 50% of patients, at least, who come in for cataract surgery are asymptomatic, but at least 80% of those patients have at least one sign of dry eye disease,” Farid said ...

The Regulatory Role of HOX interacting lncRNA in Oral Cancer - An in-silico Analysis.
https://doi.org/10.1111/jop.13329
Journal of Oral Pathology & Medicine : Official Publicati... Basavarajappa DS, Padam KSR et. al.

Jun 30th, 2022 - We aim to elucidate the interaction of long non-coding RNAs with HOX genes and their regulatory role and potential drug candidates in oral cancer. The interaction network was constructed using RNA Interactome and the RNA Interactome from the Sequencing Experiments (RISE) database. The differential expression of HOX genes and HOX interacting lncRNAs was assessed using the TCGA-HNSCC oral cancer ...

Confocal microscopy in oral cancer and oral potentially malignant disorders: A systemat...
https://doi.org/10.1111/odi.14291
Oral Diseases; Ramani RS, Tan I et. al.

Jun 30th, 2022 - To systematically identify and summarise current research on the utility of confocal microscopy in oral squamous cell carcinoma and oral epithelial dysplasia in oral potentially malignant disorders. Databases Medline, Embase, Evidence Based Medicine and Web of Science were searched with articles screened and included if their primary objective was the use of a confocal microscope in diagnosis o...

Hepatoid prostatic carcinoma with adrenal metastasis and novel genetic alterations.
https://doi.org/10.1002/dc.25006
Diagnostic Cytopathology; Ayala Soriano C, Benitez Barzaga M et. al.

Jun 30th, 2022 - Hepatoid carcinoma (HC) encompasses epithelial extrahepatic tumors exhibiting features of hepatocellular carcinoma (HCC) both by morphology and immunohistochemistry. Distinguishing metastatic HCC from HC may be challenging, particularly when limited material, such as a cytologic specimen, is available. HC from prostatic origin is unusual and has only rarely been characterized by cytology. Herei...

Artificial intelligence assisted cytological detection for early esophageal squamous ep...
https://doi.org/10.1002/cam4.4984
Cancer Medicine; Yao B, Feng Y et. al.

Jun 30th, 2022 - Manual cytological diagnosis for early esophageal squamous cell carcinoma (early ESCC) and high-grade intraepithelial neoplasia (HGIN) is unsatisfactory. Herein, we have introduced an artificial intelligence (AI)-assisted cytological diagnosis for such lesions. Low-grade squamous intraepithelial lesion or worse was set as the diagnostic threshold for AI-assisted diagnosis. The performance of AI...

Sulforaphane alleviates LPS-induced inflammatory injury in ARPE-19 cells by repressing ...
https://doi.org/10.1080/08923973.2022.2090954
Immunopharmacology and Immunotoxicology; Song H, Wang YH et. al.

Jun 30th, 2022 - Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population and its pathogenesis has been associated with inflammatory damage to retinal pigment epithelial (RPE) cells. Here, we explored the ability of sulforaphane to protect ARPE-19 cells from lipopolysaccharide (LPS)-induced inflammatory injury and elucidated the underlying molecular mechanism. Cell viab...

Highly Expressed LINC00958 Modulates the Growth and Epithelial-Mesenchymal Transition o...
https://doi.org/10.1089/cbr.2022.0005
Cancer Biotherapy & Radiopharmaceuticals; Xiao Y, He L et. al.

Jun 30th, 2022 - Objective: To determine the expression of LINC00958 (BLACAT2) in bladder cancer (BC), the most common malignancy in the urinary system, and to determine its exact mechanism of action, so as to provide novel references for future clinical diagnosis and treatment of BC and lay a foundation for the follow-up research on LINC00958. Methods: Human bladder transitional cell carcinoma cells (T24 and J...

Extracranial Craniopharyngioma Confined to the Sphenoid Sinus.
https://doi.org/10.1097/SCS.0000000000008660
The Journal of Craniofacial Surgery; Ko MC, Kim JS et. al.

Jun 29th, 2022 - Craniopharyngioma is rare epithelial tumor that develops along the craniopharyngeal duct, and most of these tumors occur in the sellar and suprasellar regions. Although it rarely occurs in the extracranial region, sphenoid solitary lesions were not reported in previous literature. In this study, we report a case of infrasellar craniopharyngioma within the sphenoid sinus without intracranial les...

Mucin 5AC expression is common but unrelated to tumor progression in pancreatic adenoca...
https://doi.org/10.1177/03946320221106504
International Journal of Immunopathology and Pharmacology; Dwertmann Rico S, Büscheck F et. al.

Jun 29th, 2022 - Introduction: Mucin 5AC (MUC5AC) belongs to the family of secreted gel-forming mucins. It is physiologically expressed in some normal mucin producing epithelial cells but also in pancreatic, ovarian, and colon cancer cells. The role of MUC5AC expression in cancer is not fully understood. This study was designed to explore the role of MUC5AC for pancreatic cancer progression, its association to ...

Long-Term Expanding Porcine Airway Organoids Provide Insights into the Pathogenesis and...
https://doi.org/10.1128/jvi.00738-22
Journal of Virology; Jiang C, Li L et. al.

Jun 29th, 2022 - Respiratory coronaviruses cause serious health threats to humans and animals. Porcine respiratory coronavirus (PRCoV), a natural transmissible gastroenteritis virus (TGEV) mutant with partial spike deletion, causes mild respiratory disease and is an interesting animal respiratory coronavirus model for human respiratory coronaviruses. However, the absence of robust ex vivo models of porcine airw...

Kaposi Varicelliform Eruption
https://emedicine.medscape.com/article/1132622-overview

Jun 28th, 2022 - Practice Essentials Kaposi varicelliform eruption (KVE) is the name given to a distinct cutaneous eruption caused by herpes simplex virus (HSV) type 1, HSV-2, coxsackievirus A16, or vaccinia virus that infects a preexisting dermatosis. Most commonly, it is caused by a disseminated HSV infection in patients with atopic dermatitis (AD) and, for this reason, is often referred to as eczema herpetic...

GLIPR1 promotes proliferation, metastasis and 5-fluorouracil resistance in hepatocellul...
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Cancer Gene Therapy; Tiu YC, Gong L et. al.

Jun 28th, 2022 - Hepatocellular carcinoma (HCC) contributes to a heavy disease burden for its high prevalence and poor prognosis, with limited effective systemic therapies available. In the era of precision medicine, treatment efficacy might be improved by combining personalized systemic therapies. Since oncogenic activation is one of the primary driving forces in HCC, characterization of these oncogenes can pr...

MHBSt167 induced autophagy promote cell proliferation and EMT by activating the immune ...
https://doi.org/10.1186/s12985-022-01840-z 10.1186/s12885-019-5916-6 10.1093/carcin/bgs365 10.1093/jnci/djp180 10.1053/j.gastro.2007.09.002 10.1016/j.jhep.2014.04.041 10.1136/gut.2008.174029 10.1093/ndt/gfp737 10.1002/j.1460-2075.1992.tb05369.x 10.3892/ol.2014.2190 10.1056/NEJMra2022774 10.1016/j.jhep.2019.08.026 10.1038/nrc3262 10.1002/hep.31209 10.2217/hep-2019-0007 10.1038/s41590-020-0622-8 10.1016/j.jhep.2011.06.028 10.1038/s41586-020-03056-z 10.1016/j.molcel.2010.09.023 10.1083/jcb.201002021 10.1016/j.tig.2017.08.004 10.1158/1541-7786.MCR-07-0098 10.1093/carcin/bgr296 10.3390/md14090166 10.1002/hep.20615 10.1101/gr.978703 10.1101/cshperspect.a012872 10.1080/10409230591008161 10.1016/j.semcancer.2019.11.007 10.3390/cells8010016 10.3390/cancers12030562 10.21037/tgh.2018.06.09 10.1002/hep.25592 10.1038/s41416-019-0441-6 10.1038/s41575-019-0145-7 10.1016/j.cellimm.2017.12.007 10.1038/nature07205 10.4161/onci.20304 10.1038/nature09782 10.1038/cmi.2018.2 10.1126/science.1136880 10.1073/pnas.0807694106 10.1073/pnas.0911267106 10.1016/j.ccell.2016.09.004 10.1172/JCI120888 10.1080/15548627.2018.1427398
Virology Journal; Cheng B, Wang Q et. al.

Jun 28th, 2022 - Hepatitis B virus can induce hepatocellular carcinoma (HCC) by inducing a host immune response against infected hepatocytes. C-terminally truncated middle surface protein (MHBSt) has been reported to contribute to HCC through transcriptional activation in epidemiology studies, while the underlying mechanism of MHBSt-induced HCC is unknown. In this study, a premature stop at codon 167 in MHBS (M...

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis.
https://doi.org/10.3791/64003
Journal of Visualized Experiments : JoVE; Burge K, Wilson A et. al.

Jun 28th, 2022 - Necrotizing enterocolitis (NEC) is a devastating disease affecting preterm infants, characterized by intestinal inflammation and necrosis. Enteroids have recently emerged as a promising system to model gastrointestinal pathologies. However, currently utilized methods for enteroid manipulation either lack access to the apical surface of the epithelium (three-dimensional [3D]) or are time-consumi...

The Semaphorin 3A-AKT axis-mediated cell proliferation in salivary gland morphogenesis ...
https://doi.org/10.1016/j.prp.2022.153991
Pathology, Research and Practice; Fujii S, Fujimoto T et. al.

Jun 28th, 2022 - We recently demonstrated that Semaphorin 3 A (Sema3A), the expression of which is negatively regulated by Wnt/β-catenin signaling, promotes odontogenic epithelial cell proliferation, suggesting the involvement of Sema3A in tooth germ development. Salivary glands have a similar developmental process to tooth germ development, in which reciprocal interactions between the oral epithelium and adjac...

Kaposi Varicelliform Eruption
https://emedicine.medscape.com/article/1132622-print

Jun 28th, 2022 - Practice Essentials Kaposi varicelliform eruption (KVE) is the name given to a distinct cutaneous eruption caused by herpes simplex virus (HSV) type 1, HSV-2, coxsackievirus A16, or vaccinia virus that infects a preexisting dermatosis. Most commonly, it is caused by a disseminated HSV infection in patients with atopic dermatitis (AD) and, for this reason, is often referred to as eczema herpetic...

Kaposi Varicelliform Eruption
http://emedicine.medscape.com/article/1132622-overview

Jun 28th, 2022 - Practice Essentials Kaposi varicelliform eruption (KVE) is the name given to a distinct cutaneous eruption caused by herpes simplex virus (HSV) type 1, HSV-2, coxsackievirus A16, or vaccinia virus that infects a preexisting dermatosis. Most commonly, it is caused by a disseminated HSV infection in patients with atopic dermatitis (AD) and, for this reason, is often referred to as eczema herpetic...

Nav1.6 promotes the progression of human follicular thyroid carcinoma cells via JAK-STA...
https://doi.org/10.1016/j.prp.2022.153984
Pathology, Research and Practice; Li H, Liu J et. al.

Jun 27th, 2022 - Follicular thyroid carcinoma (FTC) is one of the most common malignant tumors of the endocrine system. Recent studies have shown that voltage-gated sodium channels (VGSCs) affect the proliferation, migration, and invasion of tumor cells. However, the expression and functions of VGSCs, and the molecular pathways activated by VGSCs in FTC cells remain unclear. Our studies revealed that the expres...