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VIDEO: Striving for ‘one and done’ with collagen cross-linking
https://www.healio.com/news/ophthalmology/20220126/video-striving-for-one-and-done-with-collagen-crosslinking

Jan 26th, 2022 - WAIKOLOA, Hawaii — In this Healio Video Perspective from Hawaiian Eye 2022, Kathryn M. Hatch, MD, explains why cornea specialists strive for “one and done” when treating keratoconus and other epithelial defects with collagen cross-linking.

Consensus group provides imaging criteria for assessment of geographic atrophy
https://www.healio.com/news/ophthalmology/20220119/consensus-group-provides-imaging-criteria-for-assessment-of-geographic-atrophy

Jan 19th, 2022 - WAIKOLOA, Hawaii — In a series of published reports, the Classification of Atrophy Meeting group provided consensus-based imaging parameters for multimodal assessment of geographic atrophy. The group also revised the definitions of specific features of geographic atrophy (GA) and identified features that may predict progression to atrophy. “In the first CAM report, we described the imaging moda...

Address ocular surface disease before surgery to optimize patient satisfaction
https://www.healio.com/news/ophthalmology/20220117/address-ocular-surface-disease-before-surgery-to-optimize-patient-satisfaction

Jan 17th, 2022 - WAIKOLOA, Hawaii — Diagnosing and treating ocular surface disease preoperatively is one of the elements that contribute to elevated patient satisfaction postoperatively, Marjan Farid, MD, said at Hawaiian Eye 2022. “We know that 50% of patients, at least, who come in for cataract surgery are asymptomatic, but at least 80% of those patients have at least one sign of dry eye disease,” Farid said ...

The Efficacy and Safety of Anlotinib Alone and in Combination with Other Drugs in Previ...
https://doi.org/10.2174/1574892818666221122114753
Recent Patents on Anti-cancer Drug Discovery; Li S, Zhou H et. al.

Nov 24th, 2022 - Thymic epithelial tumors [TETs] are rare thoracic malignancies with no standard second-line treatment. Tumor angiogenesis is closely associated with the pathogenesis and invasiveness of TETs. Anlotinib is a small-molecule multitarget tyrosine kinase inhibitor [TKI] which inhibits tumor angiogenesis and tumor cell proliferation. Published studies have demonstrated the promising clinical effect o...

The use of fetal bovine acellular dermal matrix in severe diabetic foot ulceration and ...
https://doi.org/10.1177/17085381221141115
Vascular Gormley S, Hart O et. al.

Nov 24th, 2022 - Foot ulceration associated with diabetic foot disease (DFD) and chronic limb-threatening ischaemia (CLTI) presents a complex clinical challenge and failure to heal the wound imposes a significant risk of major limb amputation (MLA). In attempt to accelerate wound healing rates and decrease MLA, tissue engineering research into bio-engineered scaffolds and skin substitutes has become a growing a...

The prognostic role of systemic inflammatory markers in apparent early-stage ovarian ca...
https://doi.org/10.1007/s10147-022-02272-z
International Journal of Clinical Oncology; Bizzarri N, D'Indinosante M et. al.

Nov 24th, 2022 - Few studies analyzed the prognostic role of systemic inflammatory markers in early-stage ovarian cancer. The primary endpoint of the present study was to assess the prognostic impact of baseline inflammatory markers in early-stage ovarian cancer. The secondary endpoints were to compare the disease-free survival (DFS) of inflammatory markers with standard risk factors and to correlate these with...

ABO blood groups and expression of blood group antigens of epithelial ovarian cancer in...
https://doi.org/10.1002/cam4.5476
Cancer Medicine; Wang C, Zhou J et. al.

Nov 24th, 2022 - ABO blood groups has been associated with risk of several cancers; however, the results for an association with ovarian cancer are inconsistent and little is known about the expression of histo-blood group (ABH) antigens and ABO gene in ovarian tumor tissues. To assess the impact of genotype-derived ABO blood types on the risk of EOC, we conducted a case-control study in 1,870 EOC and 4,829 con...

Patients with stage IA ovarian clear cell carcinoma do not require chemotherapy followi...
https://doi.org/10.1002/cam4.5453
Cancer Medicine; Shuqing L, Zhiling Z

Nov 24th, 2022 - Ovarian clear cell carcinoma (OCCC) is an infrequent histological subtype of epithelial ovarian cancer (EOC). The present study aimed to investigate whether chemotherapy is indispensable for patients with stage IA OCCC. Data were collected from the Surveillance, Epidemiology and End Results database between 2004 and 2015. All subjects were diagnosed with stage IA OCCC, according to their postop...

Deep learning-based image analysis reveals significant differences in the number and di...
https://doi.org/10.1002/cjp2.301
The Journal of Pathology. Clinical Research; Røyset ES, Sahlin Pettersen HP et. al.

Nov 24th, 2022 - Colon mucosae of ulcerative colitis (UC) and Crohn's disease (CD) display differences in the number and distribution of immune cells that are difficult to assess by eye. Deep learning-based analysis on whole slide images (WSIs) allows extraction of complex quantitative data that can be used to uncover different inflammatory patterns. We aimed to explore the distribution of CD3 and γδ T cells in...

LncRNA TM4SF19-AS1 exacerbates cell proliferation, migration, invasion, and EMT in head...
https://doi.org/10.1080/15384047.2022.2116923
Cancer Biology & Therapy; Yu Z, Wang X et. al.

Nov 23rd, 2022 - Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous and aggressive tumor with high mortality and unfavorable prognosis. Numerous long non-coding RNAs (lncRNAs) have been confirmed to exert pivotal parts in cancers. Nevertheless, the functions of most lncRNAs in HNSCC need deeper exploration. Our present research tried to clarify the biological role of TM4SF19 antisense RNA 1 (TM4SF...

Atypical enteropathogenic E. coli are associated with disease activity in ulcerative co...
https://doi.org/10.1080/19490976.2022.2143218
Gut Microbes; Baumgartner M, Zirnbauer R et. al.

Nov 23rd, 2022 - With increasing urbanization and industrialization, the prevalence of inflammatory bowel diseases (IBDs) has steadily been rising over the past two decades. IBD involves flares of gastrointestinal (GI) inflammation accompanied by microbiota perturbations. However, microbial mechanisms that trigger such flares remain elusive. Here, we analyzed the association of the emerging pathogen atypical en...

Protrusion of KCNJ13 Gene Knockout Retinal Pigment Epithelium Due to Oxidative Stress-I...
https://doi.org/10.1167/iovs.63.12.29
Investigative Ophthalmology & Visual Science; Kanzaki Y, Fujita H et. al.

Nov 23rd, 2022 - This study was performed to elucidate the mechanisms of morphological abnormalities in a Leber congenital amaurosis 16 (LCA16) cell model using KCNJ13 knockout (KO) retinal pigment epithelial cells derived from human iPS cells (hiPSC-RPE). In KCNJ13 KO and wild-type hiPSC-RPE cells, ZO-1 immunofluorescence was performed, and confocal images were captured. The area and perimeter of each cell wer...

Increased Expression of TMPRSS11E Is Involved in LPS- or Poly(I:C)-mediated Inflammation.
https://doi.org/10.1165/rcmb.2022-0256OC
American Journal of Respiratory Cell and Molecular Biology; Zhang W, Chen Z et. al.

Nov 23rd, 2022 - Transmembrane serine proteases are a group of enzymes that are implicated in diverse biological processes. Transmembrane serine protease 11E (TMPRSS11E) is expressed in epithelial cells. Previous studies on TMPRSS11E mainly focused on its function in tumor progression. In this study, we investigated the association of TMPRSS11E with the inflammatory response. We found that TMPRSS11E levels were...

Lipolysis-stimulated lipoprotein receptor-targeted antibody-drug conjugate demonstrates...
https://doi.org/10.1016/j.neo.2022.100853
Neoplasia (New York, N.Y.); Kanda M, Serada S et. al.

Nov 23rd, 2022 - Epithelial ovarian cancer (EOC) is a lethal malignant tumor, for which new treatment options are urgently required. Lipolysis-stimulated lipoprotein receptor (LSR) is widely expressed in EOC, and it is associated with poor prognosis. In this study, we developed an antibody-drug conjugate (ADC) targeting LSR as a new therapeutic approach to EOC. We, herein, developed novel anti-LSR monoclonal an...

Huanglian Jiedu plaster ameliorated X-ray-induced radiation dermatitis injury by inhibi...
https://doi.org/10.1016/j.jep.2022.115917
Journal of Ethnopharmacology; Wang J, Xie KH et. al.

Nov 23rd, 2022 - Huanglian Jiedu plaster (HJP) is a kind of Chinese patent medicine that contains four medicinal plants. It has been clinically proven to be beneficial for the treatment of tumor-associated radiation dermatitis. However, the underlying mechanism of HJP on radiation dermatitis remains unclear. This study aims to investigate the therapeutic effect of HJP on X-ray-induced radiation dermatitis, and ...

Maxillary unicystic ameloblastoma: a rare presentation.
https://doi.org/10.1136/bcr-2022-250786
BMJ Case Reports; Imase R, Watanabe T

Nov 23rd, 2022 - Unicystic ameloblastoma (UAM), a rare variant of ameloblastoma, is an odontogenic epithelial neoplasm typically appearing in the mandible. We report an extremely rare case of maxillary UAM with an impacted canine and supernumerary tooth. The patient was a woman in her late 30s who presented with a slight expansion of the left anterior maxilla due to a cystic lesion with impacted teeth. Under a ...

FDA Requests More Restrictions on Ovarian Cancer Drugs
https://www.medscape.com/viewarticle/984547

Nov 23rd, 2022 - The US Food and Drug Administration (FDA) is moving to further restrict the use of certain PARP inhibitors in patients with ovarian cancer, citing recent data showing an increased risk for death with the agents versus chemotherapy. These restrictions could mean bankruptcy for one company. Earlier this year, several companies voluntarily withdrew their respective PARP inhibitors for heavily pret...

Human cytomegalovirus infection of epithelial cells increases SARS-CoV-2 superinfection...
https://doi.org/10.1093/infdis/jiac452
The Journal of Infectious Diseases; Perera MR, Greenwood EJ et. al.

Nov 22nd, 2022 - SARS-CoV-2, the causative agent of COVID-19, has caused widespread morbidity and mortality since its onset in late 2019. Here, we demonstrate that prior infection with human cytomegalovirus (HCMV) substantially increases infection with SARS-CoV-2 in vitro. HCMV is a common herpesvirus carried by 40-100% of the population which can reactivate in the lung under inflammatory conditions, such as th...

Oxidative Phosphorylation-Related Signature Participates in Cancer Development, and PTP...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673183
Journal of Immunology Research; Huang L, Xie Y et. al.

Nov 22nd, 2022 - Clear cell renal cell carcinoma (ccRCC) was a common cancer type diagnosed with frequent metastases, harboring an unfavorable therapeutic response, and results in a poor prognosis. More promising therapeutic targets are urgently required for treating ccRCC. This study was conducted to explore the role of oxidative phosphorylation in ccRCC development and reveal its clinical potential. We first ...

San-Zhong-Kui-Jian-Tang Exerts Antitumor Effects Associated With Decreased Cell Prolife...
https://doi.org/10.1177/15347354221134921
Integrative Cancer Therapies; Hsu PY, Chen JL et. al.

Nov 22nd, 2022 - Oral squamous cell carcinoma (OSCC) is an aggressive cancer whose 5-year survival rate remains poor. San-Zhong-Kui-Jian-Tang (SZKJT), a Chinese herbal formula, has long been used in clinical practice as adjuvant therapy in cancers. However, its therapeutic effects and molecular mechanisms in OSCC remain unclear. We investigated the potential therapeutic effects and molecular mechanism of SZKJT ...