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About 243,035 results

2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Kawasaki Disease
https://www.rheumatology.org/Portals/0/Files/Guideline-Management-Kawasaki-Disease.pdf
American College of Rheumatology; Gorelik M, .

Mar 8th, 2022 - Kawasaki disease (KD) is a medium vessel vasculitis as presented in the Chapel Hill Consensus Conference nomenclature system (1). It is 1 of 2 primary common vasculitis syndromes that predominantly affect children (the other being IgA vasculitis [Henoch-Schönlein]). KD is seen with relative frequency in young children, at an incidence rate of 25–50 cases per 100,000 persons per year in the U...

Case Report: Recurrent Malignant Struma Ovarii With Hyperthyroidism and Metastases, A R...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127674
Pathology Oncology Research : POR; Zhang R, Tian X et. al.

May 28th, 2022 - Background: SO (Struma ovarii) is a rare form of ovarian teratoma which originates from ovarian dermoid cysts. Due to the rarity of this disease, relevant studies might not be sufficiently documented, especially cases with hyperthyroidism and multiple metastases. Case Presentation: A 40-year-old female patient was admitted to our hospital due to management of early pregnancy along with a recurr...

Primary Extra-Pleura Leiomyoma: A Case Report and Literature Review.
https://doi.org/10.3390/curroncol29050240
Current Oncology (Toronto, Ont.); Ullah A, Patterson GT et. al.

May 28th, 2022 - Leiomyomas are a common type of benign soft tissue tumor arising from smooth muscle, most often occurring within females' genitourinary and gastrointestinal tract. However, primary leiomyomas of the chest wall residing in the extra-pleural space are an extremely rare subset of leiomyomatous lesion presentation. We present a case of a fifty-two-year-old male who initially presented complaining o...

Efficacy of Osimertinib in Lung Squamous Cell Carcinoma Patients with EGFR Gene Mutatio...
https://doi.org/10.3390/curroncol29050285
Current Oncology (Toronto, Ont.); Rekowska A, Rola P et. al.

May 28th, 2022 - Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and the leading cause of cancer-related mortality worldwide. It is responsible for 80-85% of lung cancer cases. NSCLC can be divided into several groups, led by adenocarcinoma (ADC)-40-50% and squamous cell carcinoma (SCC)-20-30%. The development of new molecular therapies targeting particular abnormalities such as mutati...

Treatment Outcomes for Primary Hepatic Angiosarcoma: National Cancer Database Analysis ...
https://doi.org/10.3390/curroncol29050292
Current Oncology (Toronto, Ont.); Mangla A, Cioffi G et. al.

May 28th, 2022 - To determine the risk of mortality and factors associated with survival amongst patients diagnosed with primary hepatic angiosarcoma (PHA). All patients diagnosed with hepatocellular carcinoma (HCC) or PHA from 2004 to 2014 were identified from the National Cancer Database (NCDB). Further analysis was performed within the cohort of patients with PHA to assess the impact of surgery, chemotherapy...

High phosphate intake induces bone loss in nephrectomized thalassemic mice.
https://doi.org/10.1371/journal.pone.0268732
PloS One; Wanna-Udom S, Luesiripong C et. al.

May 28th, 2022 - Although patients with either β-thalassemia or chronic kidney disease (CKD) clinically correlate with severe osteoporosis, the mechanism by which CKD exposed to high phosphate affects bone turnover has not been characterized in β-thalassemia. We aimed to determine the effects of renal insufficiency on high phosphate intake induced changes in bone metabolism after 5/6th nephrectomy in hemizygous...

JCI‑20679 suppresses the proliferation of glioblastoma stem cells by activating AMPK an...
https://doi.org/10.3892/mmr.2022.12754
Molecular Medicine Reports; Ando S, Kojima N et. al.

May 28th, 2022 - The prognosis of glioblastoma, which is the most frequent type of adult‑onset malignant brain tumor, is extremely poor. Therefore, novel therapeutic strategies are needed. Previous studies report that JCI‑20679, which is synthesized based on the structure of naturally occurring acetogenin, inhibits mitochondrial complex I and suppresses the growth of various types of cancer cells. However, the ...

Histologic and Genotypic Characterization of Lung Cancer in the Inuit Population of the...
https://doi.org/10.3390/curroncol29050258
Current Oncology (Toronto, Ont.); Goss GD, Spaans JN et. al.

May 28th, 2022 - Inuit are the Indigenous Arctic peoples and residents of the Canadian territory of Nunavut who have the highest global rate of lung cancer. Given lung cancer's mortality, histological and genomic characterization was undertaken to better understand the disease biology. We retrospectively studied all Inuit cases from Nunavut's Qikiqtani (Baffin) region, referred to the Ottawa Hospital Cancer Cen...

Invasive Fungal Disease in Patients with Chronic Lymphocytic Leukemia in Japan: A Retro...
https://doi.org/10.3390/curroncol29050264
Current Oncology (Toronto, Ont.); Yasu T, Sakurai K et. al.

May 28th, 2022 - Invasive fungal disease (IFD) is an important cause of morbidity and mortality in patients with hematological malignancies. As chronic lymphocytic leukemia (CLL) is a rare hematological malignancy in Japan, IFD incidence in Japanese patients with CLL is unclear. This study aimed to investigate IFD incidence in Japanese patients with CLL. This retrospective cohort study used data of patients wit...

Primary Angiosarcoma of the Breast: A Single-Center Retrospective Study in Korea.
https://doi.org/10.3390/curroncol29050267
Current Oncology (Toronto, Ont.); Kim YJ, Ryu JM et. al.

May 28th, 2022 - Due to the rarity of primary angiosarcoma of the breast, optimal management is based on expert opinion. The aim of this study was to review all primary angiosarcomas of the breast obtained from a single center in terms of clinicopathologic characteristics, treatment, and survival outcomes. From 1997 to 2020, 15 patients with primary angiosarcoma of the breast underwent either mastectomy or wide...

Depression, diabetes, comorbid depression and diabetes and risk of all-cause and cause-...
https://doi.org/10.1007/s00125-022-05723-4 10.1201/9780429492259
Diabetologia Prigge R, Wild SH et. al.

May 28th, 2022 - The aim of this study was to investigate the risks of all-cause and cause-specific mortality among participants with neither, one or both of diabetes and depression in a large prospective cohort study in the UK. Our study population included 499,830 UK Biobank participants without schizophrenia and bipolar disorder at baseline. Type 1 and type 2 diabetes and depression were identified using sel...

Type 2 Diabetes, Fasting Glucose, Hemoglobin A1c Levels and Risk of Primary Open-Angle ...
https://doi.org/10.1167/iovs.63.5.37
Investigative Ophthalmology & Visual Science; Hu Z, Zhou F et. al.

May 28th, 2022 - To evaluate the potential causal associations between type 2 diabetes and fasting glucose and HbA1c levels and the risk of primary open-angle glaucoma (POAG) in European and East Asian populations. We selected genetic variants (P < 5 × 10-8) for type 2 diabetes (898,130 Europeans; 433,540 East Asians), fasting glucose, and HbA1c (196,991 Europeans; 36,584 East Asians) from three meta-analyses o...

The bioinformatics and experimental analysis of the novel roles of virus infection-asso...
https://doi.org/10.18632/aging.204093
Aging Li J, Zhang X et. al.

May 28th, 2022 - Infection virus including HBV and HCV has been well recognized as a major cause inducing hepatocellular carcinoma (HCC). However, molecular investigations into the HTLV-1 (Human T-lymphotropic virus type-1) and HCC have been rare. In this study, we integrated several public datasets of HCC patients and filtered seven genes including CDC20 as the HTLV-1 infection-related genes which were differe...

Safety and Efficacy of Coformulated Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib (E7080/MK-7902) in Advanced Hepatocellular Carcinoma (MK-1308A-004)
https://clinicaltrials.gov/ct2/show/NCT04740307

May 27th, 2022 - The purpose of this study is to evaluate the safety and efficacy of fixed dose coformulated pembrolizumab/quavonlimab (MK-1308A) plus lenvatinib in a first line (1L) hepatocellular carcinoma (HCC) setting. No hypothesis testing will be performed.

Testing the Combination of Anetumab Ravtansine With Either Nivolumab, Nivolumab and Ipilimumab, or Gemcitabine and Nivolumab in Advanced Pancreatic Cancer
https://clinicaltrials.gov/ct2/show/NCT03816358

May 27th, 2022 - PRIMARY OBJECTIVE: I. To evaluate the safety and tolerability of anetumab ravtansine with the following combinations in patients with mesothelin positive pancreatic adenocarcinoma. SECONDARY OBJECTIVES: I. To assess the preliminary anti-tumor activity of anetumab ravtansine (anetumab) in combination with nivolumab, nivolumab and ipilimumab, nivolumab and gemcitabine hydrochloride (gemcitabine) ...

Moxetumomab Pasudotox-tdfk (Lumoxiti(TM)) and Either Rituximab (Rituxan(R)) or Ruxience for Relapsed Hairy Cell Leukemia
https://clinicaltrials.gov/ct2/show/NCT03805932

May 27th, 2022 - Background: Hairy cell leukemia (HCL) is an indolent CD22+ B-cell leukemia comprising 2% of all leukemias, or approximately 1200 of the 62,130 new cases of leukemia/year in the US. HCL variant (HCLv), also CD22+, is 10-20% as common as HCL, but more common in the relapsed/refractory population due to its poor prognosis and response to standard purine analog chemotherapy. HCLv cells are CD25-neg...

Men at High Genetic Risk for Prostate Cancer
https://clinicaltrials.gov/ct2/show/NCT03805919

May 27th, 2022 - Background: Prostate cancer is the most common malignancy and the second leading cause of cancer-related deaths in American men. Prostate cancer has substantial inherited predisposition and certain genetic variants that are associated with an increased risk of prostate cancer. An evolving approach to prostate cancer screening is to target populations at risk of developing prostate cancer based ...

Cell Collection to Study Eye Diseases
https://clinicaltrials.gov/ct2/show/NCT01432847

May 27th, 2022 - This study will establish a repository of biospecimens to generate induced pluripotent stem (iPS) cells, which will be used to determine molecular mechanisms for potentially blinding eye diseases including but not limited to: Best Vitelliform Dystrophy (Best Disease); Late-Onset Retinal Degeneration (L-ORD); Age-Related Macular Degeneration (AMD); Leber congenital amaurosis (LCA); Joubert syndr...

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients
https://clinicaltrials.gov/ct2/show/NCT03745326

May 27th, 2022 - Background: We generated an HLA-A11:01-restricted murine T-cell receptor (mTCR) that specifically recognizes the G12D-mutated variant of KRAS (and other RAS family genes) expressed by many human cancers and constructed a single retroviral vector that contains alpha and beta chains that confer recognition of this antigen when transduced into PBL. In co-cultures with HLA-A11:01+ target cells expr...

Assessment of Bone Mineral Density in People Living With HIV and KSHV Associated Malignancies: A Retrospective Longitudinal Analysis
https://clinicaltrials.gov/ct2/show/NCT04742387

May 27th, 2022 - Title: Assessment of Bone Mineral Density in People Living with HIV and KSHV Associated Malignancies: A Retrospective Longitudinal Analysis Study Description: This is a retrospective review that includes all participants with human immunodeficiency virus (HIV) (PWH) affected by Kaposi sarcoma (KS), KSHV-associated multicentric Castleman disease, and KSHV associated inflammatory cytokine syndrom...