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About 138,948 results

RECOVER Researchers Express Hope and Frustration in Their Study of Long COVID
https://www.medpagetoday.com/special-reports/exclusives/99403
MedPage Today; DePeau-Wilson M.

Jul 23rd, 2022 - Slow enrollment has led to simmering frustrations over the progress and potential of the NIH's RECOVER Initiative, the research consortium focused on studying post-acute sequelae of SARS-CoV-2, or long COVID, according to researchers and leaders within the initiative. The RECOVER Initiative was designed to support research on long COVID across the U.S., including among every group of people ...

A Study to Evaluate Subcutaneous Daratumumab in Combination With Standard Multiple Myeloma Treatment Regimens
https://clinicaltrials.gov/ct2/show/NCT03412565

Sep 9th, 2022 - The hypothesis is that the addition of daratumumab administered SC to standard MM regimens will improve responses compared to response data observed in completed phase 3 studies without daratumumab. Disease evaluations will include measurements of myeloma proteins, bone marrow examinations, skeletal surveys, assessment of extramedullary plasmacytomas, and measurements of serum calcium corrected...

Rebound of SARS-CoV-2 Infection after Nirmatrelvir–Ritonavir Treatment
https://www.nejm.org/doi/full/10.1056/NEJMc2206449
The New England Journal of Medicine; Charness ME, .

Sep 15th, 2022 - Nirmatrelvir is an inhibitor of the main protease in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has been shown to block viral replication and reduce disease severity in unvaccinated persons at risk for the progression of coronavirus disease 2019 (Covid-19).1 Here, we describe the occurrence of rebound symptoms and viral replication after treatment with nirmatrelvir combin...

How deadly is monkeypox? What scientists know
https://www.nature.com/articles/d41586-022-02931-1
Nature Kozlov M.

Sep 13th, 2022 - The global monkeypox outbreak has caused some deaths, but the death rate is lower than expected from historical data — and scientists are breathing a cautious sigh of relief. Out of more than 57,000 people confirmed to have had monkeypox infections, at least 22 have died, representing a death rate of about 0.04%. That’s significantly less than the 1–3% that has been reported during outbreaks ca...

Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT)
https://www.bmj.com/content/378/bmj-2022-071230
BMJ Jolliffe D A, Holt H et. al.

Sep 7th, 2022 - The covid-19 pandemic has refocused attention on strategies to prevent acute respiratory tract infection. Although vaccination against SARS-CoV-2 represents the mainstay for disease control, its effectiveness at a global level is compromised by factors such as cost, availability, vaccine hesitancy, vaccine failure, and vaccine escape.123 Complementary, low cost approaches to enhance immunity to...

Associations of Depression, Anxiety, Worry, Perceived Stress, and Loneliness Prior to Infection With Risk of Post–COVID-19 Conditions
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2796097
JAMA Psychiatry; Wang S, Quan L et. al.

Sep 7th, 2022 - Postacute sequelae of SARS-CoV-2, sometimes called long COVID, are defined as signs and symptoms consistent with COVID-19 that extend beyond 4 weeks from onset of infection and constitute an emerging health issue.1 Common symptoms of post–COVID-19 conditions include fatigue, brain fog, dyspnea, digestive issues, loss of taste and smell, and depression,2,3 which may persist for months after init...

Myocarditis After BNT162b2 COVID-19 Third Booster Vaccine in Israel
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.060961
Circulation Mevorach D, .

Sep 7th, 2022

How nasal-spray vaccines could change the pandemic
https://www.nature.com/articles/d41586-022-02824-3
Nature Waltz E.

Sep 6th, 2022 - Are sprays the future of COVID-19 vaccines? That’s the hope of dozens of research groups and companies working on new kinds of inoculation. Rather than relying on injections, these use sprays or drops administered through the nose or mouth that aim to improve protection against the virus SARS-CoV-2.

Evidence of human-to-dog transmission of monkeypox virus
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01487-8/fulltext
The Lancet; Seang S, .

Aug 27th, 2022 - Human monkeypox virus is spreading in Europe and the USA among individuals who have not travelled to endemic areas.1 On July 23, 2022, monkeypox was declared a Public Health Emergency of International Concern by WHO Director-General Tedros Adhanom Ghebreyesus.2 Human-to-human transmission of monkeypox virus usually occurs through close contact with the lesions, body fluids, and respiratory drop...

Could tiny blood clots cause long COVID’s puzzling symptoms?
https://www.nature.com/articles/d41586-022-02286-7
Nature Willyard C.

Aug 24th, 2022 - When Lara Hawthorne, an illustrator in Bristol, UK, began developing strange symptoms after having COVID-19, she hoped that they weren’t due to the virus. Her initial illness had been mild. “I’ve been triple vaccinated. I felt quite protected,” she says. But months later, she was still sick with a variety of often debilitating symptoms: earaches, tinnitus, congestion, headaches, vertigo, heart ...

Monkeypox: Fractional vaccine doses will be piloted as new treatment trial launches
https://www.bmj.com/content/378/bmj.o2080
BMJ Mahase E.

Aug 23rd, 2022 - Smaller doses of the smallpox vaccine, used to provide protection against monkeypox, will be piloted at NHS sites in London and Manchester to maximise supply, the UK Health Security Agency (UKHSA) has announced. In the pilot scheme—which will take place at Chelsea and Westminster NHS Foundation Trust, Central and North West London NHS Foundation Trust, and Locala Health and Wellbeing in Grea...

US CDC announces major changes after criticism of its responses to covid-19 and monkeypox
https://www.bmj.com/content/378/bmj.o2074
BMJ Tanne JH.

Aug 23rd, 2022 - The US national public health agency, the Centers for Disease Control and Prevention (CDC), will make major changes to its structure and systems in the light of a review of its emergency response to the covid-19 pandemic.

COVID-19 Disease Severity in Persons Infected With Omicron BA.1 and BA.2 Sublineages and Association With Vaccination Status
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2795326
JAMA Internal Medicine; Butt AA, Dargham SR et. al.

Aug 22nd, 2022 - Infection with the SARS-CoV-2 Omicron variant is associated with less severe disease compared with the Delta variant.1-3 Two main Omicron sublineages—BA.1 and BA.2—have variable geographic distribution. In Qatar, BA.1 was initially predominant but was quickly replaced by BA.2 as the predominant sublineage. This study sought to determine and compare the severity of SARS-CoV-2 infection among per...

Which COVID boosters to take and when: a guide for the perplexed
https://www.nature.com/articles/d41586-022-02221-w
Nature Ledford H.

Aug 19th, 2022 - The next generation of COVID-19 vaccines is on its way, but those shots will be looking to take a seat at an already crowded table. On the menu in some countries this autumn will be the familiar standards — mRNA and protein vaccines based on the spike protein from the ancestral version of SARS-CoV-2, which ushered in the pandemic. Alongside them will be a smattering of new specials, includin...

CDC Examines Monkeypox's Ability to Linger on Home Surfaces
https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/100325
MedPage Today; Hein I.

Aug 19th, 2022 - Commonly used household surfaces in the Utah home of two infected and symptomatic monkeypox patients were covered with PCR-detected virus, yet no samples were culturable, according to a CDC investigation.

High-Contact Object and Surface Contamination in a Household of Persons with Monkeypox Virus Infection — Utah, June 2022
https://www.cdc.gov/mmwr/volumes/71/wr/mm7134e1.htm?s_cid=mm7134e1.htm_x
MMWR and Morbidity and Mortality Weekly Report; Pfeiffer JA, Collingwood A et. al.

Aug 19th, 2022 - In May 2022, the Salt Lake County Health Department reported two real-time polymerase chain reaction (PCR)–confirmed travel-associated cases of monkeypox to the Utah Department of Health and Human Services (UDHHS). The two persons with monkeypox (patients A and B) lived together without other housemates. Both persons experienced prodromal symptoms (e.g., fatigue and body aches).

Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19
https://www.nejm.org/doi/full/10.1056/NEJMoa2201662
The New England Journal of Medicine; Bramante CT, .

Aug 18th, 2022 - Early treatment to prevent severe coronavirus disease 2019 (Covid-19) is an important component of the comprehensive response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.

Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(22)00260-7/fulltext
The Lancet Psychiatry; Taquet M, .

Aug 17th, 2022 - COVID-19 is associated with increased risks of neurological and psychiatric sequelae in the weeks and months thereafter. How long these risks remain, whether they affect children and adults similarly, and whether SARS-CoV-2 variants differ in their risk profiles remains unclear.

Awareness of SARS-CoV-2 Omicron Variant Infection Among Adults With Recent COVID-19 Seropositivity
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2795246
JAMA Network Open; Joung SY, Ebinger JE et. al.

Aug 17th, 2022 - The rapid spread of the SARS-CoV-2 Omicron variant across communities worldwide has been attributed to several factors, including transmissibility features of the viral variant, limited coverage by available vaccines, and changes in face mask use and socializing behaviors.1,2 In particular, alterations of the Omicron variant have been implicated because of its greater transmissibility compared ...

How much virus does a person with COVID exhale? New research has answers
https://www.nature.com/articles/d41586-022-02202-z
Nature Prillaman M.

Aug 17th, 2022 - People infected with the highly transmissible Alpha, Delta and Omicron variants of SARS-CoV-2 spew out higher amounts of virus than do those infected with other variants, according to a study1. Furthermore, individuals who contract COVID-19 after vaccination, and even after a booster dose, still shed virus into the air.