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Table - Duration of Infectious Virus Shedding by SARS-CoV-2 Omicron Variant–Infected Vaccinees
https://wwwnc-origin.cdc.gov/eid/article/28/5/22-0197-t1
Emerging Infectious Diseases;

May 11th, 2022 - Table: Overview of 18 cases of SARS-CoV-2 infection caused by the Omicron variant, Japan, November 29–December 18, 2021*

Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial
https://www.sciencedirect.com/science/article/pii/S0188440922000455?via=ihub
Archives of Medical Research; Villasis-Keever MA, .

Apr 18th, 2022 - Background . Associations between vitamin D (VD) deficiency and the risk of SARS-CoV-2 infection have been documented in cross-sectional population studies. Intervention studies in patients with moderate to severe COVID-19 have failed to consistently document a beneficial effect.

Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from th...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00327-0/fulltext
The Lancet; Menni C, .

Apr 7th, 2022 - On Nov 26, 2021, WHO designated the SARS-CoV-2 variant B.1.1.529 (omicron), first seen in South Africa, as a new variant of concern.1 Of the many mutations detected in omicron, more than 30 are in the spike protein and 15 are in the receptor-binding domain, which could affect transmission, disease presentation, and natural or vaccine-induced protective immunity.1 In the subsequent weeks, omicro...

Why the WHO took two years to say COVID is airborne
https://www.nature.com/articles/d41586-022-00925-7
Nature Lewis D.

Apr 6th, 2022 - Early in the pandemic, the World Health Organization stated that SARS-CoV-2 was not transmitted through the air. That mistake and the prolonged process of correcting it sowed confusion and raises questions about what will happen in the next pandemic.

Glasses and risk of COVID-19 transmission - analysis of the Virus Watch Community Cohort study
https://www.medrxiv.org/content/10.1101/2022.03.29.22272997v1
Medrxiv Navaratnam AM

Apr 4th, 2022 - Background Respiratory viruses, including SARS-CoV-2, can infect the eyes or pass into the nose via the nasolacrimal duct. The importance of transmission via the eyes is unknown but might plausibly be reduced in those who wear glasses. Previous studies have mainly focussed on protective eyewear in healthcare settings.

Dietary Supplements for Eye Conditions: What the Science Says
https://www.nccih.nih.gov/health/providers/digest/dietary-supplements-for-eye-conditions-science?nav=govdcd
NCCIH Clinical Digest for Health Professionals; National Center for Complementary and Integrative Health (NCCIH)

Mar 31st, 2022 - Findings from the Age-Related Eye Disease Studies (AREDS and AREDS2) suggest that dietary supplementation with antioxidant vitamins and zinc may slow the progression of age-related macular degeneration in people who have intermediate AMD and those who have late AMD in one eye.

Ambient air pollution and COVID-19 risk: Evidence from 35 observational studies
https://www.sciencedirect.com/science/article/pii/S0013935121013608?via=ihub
Environmental Research; Zang ST, .

Mar 30th, 2022 - Coronavirus disease 2019 (COVID-19) is induced by a previously undiscovered coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Lu et al., 2020). Since SARS-CoV-2 was first discovered in December 2019, as of April 25, 2021, more than four million fatalities have been attributed to COVID-19, accounting for approximately 2% of the infected cases (>214 million)...

WHO consolidated guidelines on tuberculosis Module 5: Management of tuberculosis in children and adolescents
https://www.who.int/publications/i/item/9789240046764
World Health Organization (WHO)

Mar 21st, 2022 - The Updated guidelines on Management of tuberculosis in children and adolescents include new recommendations that cover diagnostic approaches for TB, shorter treatment for children with non-severe drug-susceptible TB, a new option for the treatment of TB meningitis, the use of bedaquiline and delamanid in young children with multidrug- and rifampicin-resistant TB and decentralized and family-ce...

Duration of Infectious Virus Shedding by SARS-CoV-2 Omicron Variant–Infected Vaccines
https://wwwnc.cdc.gov/eid/article/28/5/22-0197_article
Emerging Infectious Diseases; Takahash K, Ishikane M et. al.

Mar 15th, 2022 - To determine virus shedding duration, we examined clinical samples collected from the upper respiratory tracts of persons infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in Japan during November 29–December 18, 2021. Vaccinees with mild or asymptomatic infection shed infectious virus 6–9 days after onset or diagnosis, even after symptom resolution.

Vaccine Researcher Who Developed Tinnitus After COVID Shot Calls for Further Study
https://www.medpagetoday.com/special-reports/exclusives/97592
MedPage Today; Henderson J.

Mar 9th, 2022 - Gregory Poland, MD, director of the Mayo Clinic's Vaccine Research Group in Rochester, Minnesota, remains a steadfast vaccination advocate -- even though he developed tinnitus soon after receiving his second dose of COVID vaccine.

2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Kawasaki Disease
https://www.rheumatology.org/Portals/0/Files/Guideline-Management-Kawasaki-Disease.pdf
American College of Rheumatology; Gorelik M, .

Mar 8th, 2022 - Kawasaki disease (KD) is a medium vessel vasculitis as presented in the Chapel Hill Consensus Conference nomenclature system (1). It is 1 of 2 primary common vasculitis syndromes that predominantly affect children (the other being IgA vasculitis [Henoch-Schönlein]). KD is seen with relative frequency in young children, at an incidence rate of 25–50 cases per 100,000 persons per year in the U...

SARS-CoV-2 is associated with changes in brain structure in UK Biobank
https://www.nature.com/articles/s41586-022-04569-5
Nature Douaud G, .

Mar 7th, 2022 - There is strong evidence for brain-related abnormalities in COVID-191–13. It remains unknown however whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing to brain pathology. Here, we investigated brain changes in 785 UK Biobank participants (aged 51–81) imaged twice, including 401 cases who tested positive for i...

Molnupiravir’s authorisation was premature
https://www.bmj.com/content/376/bmj.o443
BMJ Brophy JM.

Mar 3rd, 2022 - On 1 October 2021 Merck issued a press release1 reporting an interim analysis of Move-Out, a phase 3 randomised placebo controlled trial in unvaccinated adults with confirmed SARS-Co-V infection and mild-to-moderate symptoms outside hospital. The press release stated that molnupiravir, a nucleoside analogue that inhibits viral replication by mutagenesis, reduced risk of hospital admission or de...

An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques
https://www.biorxiv.org/content/10.1101/2022.02.25.481974v1
BioRxiv Madden PJ, .

Feb 28th, 2022 - Because of the recognized systemic nature of SARS-CoV-2 infection, a non-invasive and unbiased method is needed to clarify its spatiotemporal dynamics in vivo after transmission. We recently developed a probe based on the anti-SARS-CoV-2 spike antibody CR3022 to study SARS-CoV-2 pathogenesis in vivo. Herein, we describe its use in immunoPET to investigate SARS-CoV-2 infection of rhesus macaques.

SARS-CoV-2 emergence very likely resulted from at least two zoonotic events
https://zenodo.org/record/6291628
Zenodo Pekar JE, .

Feb 26th, 2022 - Understanding the circumstances that lead to pandemics is critical to their prevention. Here, we analyze the pattern and origin of genomic diversity of SARS-CoV-2 early in the COVID-19 pandemic. We show that the SARS-CoV-2 genomic diversity prior to February 2020 comprised only two distinct viral lineages—denoted A and B—with no transitional haplotypes. Novel phylodynamic rooting methods, coupl...

Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line
https://www.mdpi.com/1467-3045/44/3/73/htm
Current Issues in Molecular Biology; Aldén M, .

Feb 25th, 2022 - Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro.

Evolving Patterns of Metastasis in Renal Cell Carcinoma: Do We Need to Perform Routine Bone Imaging?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523177/
Journal of Kidney Cancer and VHL; Lin J

Oct 13th, 2021 - Advance diagnostic and treatment modalities have improved outcomes for renal cell carcinoma (RCC) patients, but the prognosis for those with metastatic disease (mRCC) remains poor. As given metastatic distribution is critical in guiding treatment decisions for mRCC patients, we evaluated evolving metastatic patterns to assess if our current practice standards effectively address patient needs.

Germline Variants Identified in Patients with Early-onset Renal Cell Carcinoma Referred for Germline Genetic Testing
https://pubmed.ncbi.nlm.nih.gov/34654685/
European Urology Oncology; Truong H

Oct 12th, 2021 - Despite guidelines recommending genetic counseling for patients with early-onset renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations and clinical associations in patients with early-onset RCC are lacking.

Surveillance of SARS-CoV-2 in the environment and animal samples of the Huanan Seafood Market
https://www.researchsquare.com/article/rs-1370392/v1
Research Square; Gao G, .

Feb 22nd, 2022 - Emerging in December 2019, coronavirus disease 2019 (COVID-19) eventually became a pandemic and has posed a tremendous threat to global public health. However, the origins of SARS-CoV-2, the causative agent of COVID-19, remain to be determined. It has reported that a certain number of the early case clusters had a contact history with Huanan Seafood Market.

Covid-19: Antibodies after AstraZeneca and Pfizer vaccines decrease with age and are higher in women, data show
https://www.bmj.com/content/376/bmj.o428
BMJ Iacobucci G.

Feb 18th, 2022 - SARS-CoV-2 antibody levels after receiving the AstraZeneca or Pfizer-BioNTech vaccine decrease with age and are higher in females and people with prior infection, show data from the Real-time Assessment of Community Transmission (React-2) study.1