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About 190,115 results

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Sodium Butyrate Alleviates Intestinal Inflammation in Mice with Necrotizing Enterocolitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526205
Mediators of Inflammation; Sun Q, Ji YC et. al.

Oct 23rd, 2021 - To determine the role of sodium butyrate in intestinal inflammation via regulation of high-mobility group box-1 (HMGB1), we analyzed the potential mechanism in necrotizing enterocolitis (NEC) in a neonatal mouse model. A NEC model was created with hypoxia and cold exposure and artificial overfeeding. C57BL/6 neonatal mice were randomized into three groups: the control, untreated NEC, and sodium...

Intraarterial Lidocaine Administration for Pain Control by Water-in-Oil Technique in Tr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502067
Journal of Hepatocellular Carcinoma; Wang LZ, Hu XX et. al.

Oct 23rd, 2021 - To investigate the sustained release of lidocaine from a lidocaine-epirubicin-lipiodol emulsion created by water-in-oil (W/O) technique in vivo and evaluate the efficacy and safety of intraarterial lidocaine administration for intra- and postoperative pain control in transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). The in vivo concentrations of lidocaine were determine...

Double immune reconstitution therapy: cladribine after alemtuzumab in treatment of mult...
https://doi.org/10.1111/ene.15153
European Journal of Neurology; Adamec I, Jovanović I et. al.

Oct 23rd, 2021 - Alemtuzumab, a monoclonal anti-CD52 antibody, and cladribine, a purine nucleoside analogue, are used for treatment of highly active relapsing remitting multiple sclerosis (MS). Both are administered as two short yearly courses but possess the ability to induce long-term remission labeling them as immune reconstitution therapies. Although disease activity after alemtuzumab administration is rare...

Real-life isoniazid and rifampicin plasma concentrations in children: a tool for therap...
https://doi.org/10.1186/s12879-021-06764-7 10.4103/ijmr.IJMR_1961_16 10.1128/AAC.00693-15 10.1093/jac/dkv148 10.1080/17425255.2018.1416093 10.1111/apm.12590 10.1517/17425255.2016.1162785 10.1128/AAC.00756-15 10.1016/j.ijid.2014.12.001 10.1086/598192 10.1136/adc.2004.052175 10.1002/bmc.2920 10.1016/j.jpba.2007.10.025 10.1046/j.1445-5994.2003.00390.x 10.1136/adc.2004.052175 10.1159/000321045 10.1016/S0378-4347(01)00434-0 10.1093/jac/dku210 10.1016/j.ijantimicag.2017.12.004 10.1016/j.ijantimicag.2014.04.019 10.1086/598192 10.1128/AAC.05429-11 10.1371/journal.pone.0102047 10.1371/journal.pmed.1002595 10.1186/s41043-017-0132-y 10.1111/jpc.13458 10.2196/mhealth.8130 10.1186/s13063-019-3483-4 10.2196/mhealth.6837 10.3346/jkms.2020.35.e92 10.1080/02770903.2019.1635153 10.2217/pgs-2018-0166 10.1128/AAC.01833-10 10.1080/17512433.2017.1246179
BMC Infectious Diseases; Tersigni C, Boiardi G et. al.

Oct 23rd, 2021 - Low plasma levels of first-line antitubercular drugs can be counted among the main causes of poor response to antitubercular therapy, and therapeutic drug monitoring has been proposed as a method to promote tailored treatments for both child and adult patients. The main aim of the study was to evaluate serum concentrations of isoniazid (INH) and rifampicin (RIF) and to investigate reasons for s...

Preemptive analgesic effectiveness of single dose intravenous ibuprofen in infants unde...
https://doi.org/10.1186/s12887-021-02907-6 10.1016/j.clp.2015.02.005 10.1016/B978-0-323-06612-9.00025-0 10.1111/j.0001-5172.2004.00407.x 10.1111/j.1365-2044.1995.tb04509.x 10.1597/1545-1569_2002_039_0145_aofpao_2.0.co_2 10.1213/00000539-199377020-00026 10.1016/j.joms.2018.09.010 10.1111/pan.12302 10.1097/00000539-200104000-00020 10.1111/pan.12393 10.1016/j.phrs.2011.08.010 10.1111/pan.12381 10.1016/0952-8180(94)00001-k 10.1542/peds.2007-0064 10.1046/j.1460-9592.2000.00530.x 10.1597/14-080 10.1111/j.1460-9592.2006.02018.x 10.1111/j.1460-9592.2010.03347.x 10.1093/bja/74.5.506 10.1111/j.1460-9592.2010.03262.x 10.1097/SCS.0000000000006633 10.1097/EJA.0000000000000900 10.1097/PEC.0000000000001505
BMC Pediatrics; Peng ZZ, Wang YT et. al.

Oct 23rd, 2021 - Correction surgery for cleft palate is recommended between 9 and 18 months of age. Patients suffer from acute pain after palatoplasty. Clinicians are hesitant to use opioids for analgesia concerning the potential high risk of respiratory adverse events. Intravenous ibuprofen perhaps be a suitable adjuvant to pain relief. We try to assess whether preoperative administration of intravenous ibupro...

Injectable Hypomethylating Agents for Management of Myelodysplastic Syndromes: Patients...
https://doi.org/10.1016/j.clml.2021.09.009
Clinical Lymphoma, Myeloma & Leukemia; Zeidan AM, Jayade S et. al.

Oct 23rd, 2021 - Until recently, patients with MDSs could receive HMAs via intravenous (IV) or subcutaneous (SC) administration. An oral HMA was recently approved as an alternative to IV/SC administration. This study assessed the impact of IV/SC HMA on MDS patients, and their experience of, challenges with, and views about oral MDS treatment. We conducted an online cross-sectional survey among adult MDS patient...

β3 adrenergic receptor as potential therapeutic target in ADPKD.
https://doi.org/10.14814/phy2.15058
Physiological Reports; Schena G, Carmosino M et. al.

Oct 23rd, 2021 - Autosomal dominant polycystic kidney disease (ADPKD) disrupts renal parenchyma through progressive expansion of fluid-filled cysts. The only approved pharmacotherapy for ADKPD involves the blockade of the vasopressin type 2 receptor (V2R). V2R is a GPCR expressed by a subset of renal tubular cells and whose activation stimulates cyclic AMP (cAMP) accumulation, which is a major driver of cyst gr...

Pituitary Disease and Pregnancy
https://emedicine.medscape.com/article/127650-print

Oct 22nd, 2021 - The pituitary gland generally undergoes an increase in size during pregnancy, which is mainly due to an increase in blood supply, as it is a highly vascular organ. Some of the volume increase may also occur as a result of estrogen-mediated hyperprolactinemia caused by lactotroph hyperplasia. Despite the increase in size of the pituitary gland during pregnancy, pituitary function usually remains...

COVID-19 Vaccines
https://emedicine.medscape.com/article/2500139-overview

Oct 22nd, 2021 - Overview After publication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genetic sequence on January 11, 2020, research and collaboration among scientists and biopharmaceutical manufacturers quickly followed. Various methods are used for vaccine discovery and manufacturing. As of October 21, 2021, The New York Times Coronavirus Vaccine Tracker lists one vaccine (Comirnaty;...

Phase 1a/1b Study of TPST-1495 as a Single Agent and in Combination With Pembrolizumab in Subjects With Solid Tumors
https://clinicaltrials.gov/ct2/show/NCT04344795

Oct 22nd, 2021 - This is a first-in-human Phase 1a/1b, multicenter, open-label, dose-escalation, dose and schedule optimization, and expansion study of TPST-1495 as a single agent and in combination with pembrolizumab to determine its MTD, safety, tolerability, pharmacokinetics (PD), pharmacodynamics (PK) and preliminary anti-tumor activity in subjects with advanced solid tumors. Subjects with all histologic ty...

Ozone Plasma on Lung Function and Inflammatory Parameters in Pulmonary Sequelae Associated With Coronavirus 19 Infection
https://clinicaltrials.gov/ct2/show/NCT05089305

Oct 22nd, 2021 - The objective of this study is to evaluate whether the administration by inhalation of ozone plasma favorably modifies lung function and inflammatory parameters in patients with pulmonary sequelae associated with coronavirus 19 infection (SARS-COV-2). We will conduct an open-ended, uncontrolled clinical trial in 35 male and female patients, between 25-80 years of age with previous confirmed dia...

Efficacy and Safety of Intrathecal OAV101 (AVXS-101) in Pediatric Patients With Type 2 Spinal Muscular Atrophy (SMA)
https://clinicaltrials.gov/ct2/show/NCT05089656

Oct 22nd, 2021 - This is a multi-center, randomized, sham-controlled, double-blind study to investigate the safety, tolerability, and efficacy of IT OAV101 in SMA participants, sitting and never ambulatory. The study will enroll treatment naive Type 2 SMA participants who are ≥ 2 years to < 18 years who harbor biallelic SMN1 pathogenic variants in SMN1 and 2-4 copies of SMN2. The study consists of a Screening a...

In Vivo Characterization of Inflammation With Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging
https://clinicaltrials.gov/ct2/show/NCT02511028

Oct 22nd, 2021 - Objective The goals of this pilot study are to (1) demonstrate the safety of ferumoxytol, a United States Food and Drug Administration (FDA) approved drug used in the treatment of iron deficiency anemia, as a contrast agent for brain magnetic resonance imaging (MRI), as determined by a lack of long-term signal change in healthy volunteers (HV) and people with multiple sclerosis (MS); (2) determ...

Denosumab-related osteonecrosis of the external auditory canal-benefit of the early sur...
https://doi.org/10.1177/01455613211053389
Ear, Nose, & Throat Journal; Peřina V, Salzman R et. al.

Oct 22nd, 2021 - Background: Antiresorptive drugs are widely used to reduce bone mineral loss in patients with osteoporosis and to prevent skeletal-related events in patients with metastatic cancers and multiple myeloma (MM). Both the bisphosphonates (BP) and denosumab typically used in this indication were shown to be effective and relatively safe. Obviously, this medication could have some adverse effects; on...

Complement C3 mediates early hippocampal neurodegeneration and memory impairment in exp...
https://doi.org/10.1016/j.nbd.2021.105533
Neurobiology of Disease; Bourel J, Planche V et. al.

Oct 22nd, 2021 - Memory impairment is one of the disabling manifestations of multiple sclerosis (MS) possibly present from the early stages of the disease and for which there is no specific treatment. Hippocampal synaptic dysfunction and dendritic loss, associated with microglial activation, can underlie memory deficits, yet the molecular mechanisms driving such hippocampal neurodegeneration need to be elucidat...

Small molecule drugs for atopic dermatitis, rheumatoid arthritis, and hereditary angioe...
https://doi.org/10.1016/j.anai.2021.10.015
Annals of Allergy, Asthma & Immunology : Official Publica... Geng B, Craig TJ

Oct 22nd, 2021 - To review recent trends in the development of targeted small molecule drugs (SMDs) for the treatment of immunologically driven disorders, including atopic dermatitis, rheumatoid arthritis, and hereditary angioedema. Data sources include peer-reviewed published literature from the PubMed database, published abstracts from scientific/medical meetings, and medication information from the Drugs@FDA...

Evaluation of Cardiac Adverse Events Associated with Carfilzomib Using a Japanese Real-...
https://doi.org/10.1159/000519687
Oncology Nakao S, Uchida M et. al.

Oct 22nd, 2021 - Carfilzomib is a proteasome inhibitor widely used for the treatment of multiple myeloma. However, cardiac adverse events (CAEs) are a serious side effect of carfilzomib administration. Observational studies based on systematic reviews and real-world data have revealed that the risk of CAEs tends to be high. However, there have been no reports on the incidence of CAEs associated with carfilzomib...

Mycobacterium porcinum Skin and Soft Tissue Infections After Vaccinations - Indiana, Ke...
https://doi.org/10.15585/mmwr.mm7042a3
MMWR. Morbidity and Mortality Weekly Report; Blau EF, Flinchum A et. al.

Oct 22nd, 2021 - During December 2018-February 2019, a multistate investigation identified 101 patients with vaccination-associated adverse events among an estimated 940 persons in Kentucky, Indiana, and Ohio who had received influenza; hepatitis A; pneumococcal; or tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines at the workplace during September 11-November 28, 2018. These va...

TRPV4 is activated by mechanical stimulation to induce prostaglandins release in trabec...
https://doi.org/10.1371/journal.pone.0258911
PloS One; Uchida T, Shimizu S et. al.

Oct 22nd, 2021 - Trabecular meshwork constitutes the conventional outflow pathway and controls intraocular pressure by regulating aqueous outflow. Mechanical stimulation has been studied as one of the triggers to regulate aqueous outflow in trabecular meshwork, but it is not well understood. We investigated that how transient receptor potential cation channel subfamily V member 4 (TRPV4) functions in human trab...