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About 24,865 results

Plasmodium malariae contributes to high levels of malaria transmission in a forest-sava...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875470
Parasites & Vectors; Nguiffo-Nguete D, Nongley Nkemngo F et. al.

Jan 26th, 2023 - Malaria control efforts are highly skewed towards Plasmodium falciparum while overlooking other Plasmodium species such as P. malariae. A better understanding of the role of Plasmodium species other than P. falciparum is needed to strengthen malaria elimination initiatives. The aim of the present study was to elucidate the contribution of P. malariae to malaria transmission in Cameroon. The stu...

Clonorchis sinensis aggravates biliary fibrosis through promoting IL-6 production via t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873171
PLoS Neglected Tropical Diseases; Wang Y, Zhang X et. al.

Jan 25th, 2023 - Clonorchis sinensis is an important food-borne zoonotic parasite which has been linked to biliary fibrosis and cholangiocarcinoma. However, the details of the pathogenesis of C. sinensis were unclear. To explore the role and regulatory mechanism of toll-like receptor 2 (TLR2) in C. sinensis-induced biliary fibrosis, we established the C. sinensis-infected C57BL/6 mouse model with TLR2-/- and wi...

Role of Pfs47 in the dispersal of ancestral Plasmodium falciparum malaria through adapt...
https://doi.org/10.1073/pnas.2213626120
Proceedings of the National Academy of Sciences of the Un... Molina-Cruz A, Canepa GE et. al.

Jan 24th, 2023 - Plasmodium falciparum malaria originated when Plasmodium praefalciparum, a gorilla malaria parasite transmitted by African sylvan anopheline mosquitoes, adapted to humans. Pfs47, a protein on the parasite surface mediates P. falciparum evasion of the mosquito immune system by interacting with a midgut receptor and is critical for Plasmodium adaptation to different anopheline species. Genetic an...

Transmission efficiency of Plasmodium vivax at low parasitaemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854148
Malaria Journal; Surit T, Sripoorote P et. al.

Jan 20th, 2023 - Plasmodium vivax is responsible for much of malaria outside Africa. Although most P. vivax infections in endemic areas are asymptomatic and have low parasite densities, they are considered a potentially important source of transmission. Several studies have demonstrated that asymptomatic P. vivax carriers can transmit the parasite to mosquitoes, but the efficiency has not been well quantified. ...

Prevalence of malaria and associated clinical manifestations and myeloperoxidase amongs...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850770
Malaria Journal; Ngum NH, Fakeh NB et. al.

Jan 20th, 2023 - Malaria is a growing problem in Africa, with prevalence varies from areas to areas due to several factors including the altitude. This study aimed to investigate the malaria distribution and its relationship with level of some blood parameters and plasma myeloperoxidase (MPO) in population of three localities with different altitudes. A total of 150 participants were recruited in each locality ...

Differential paired stage-specific expression of Babesia bovis cysteine-rich GCC2/GCC3 ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843837
Parasites & Vectors; Hussein HE, Johnson WC et. al.

Jan 18th, 2023 - Babesia bovis, an intra-erythrocytic apicomplexan parasite, is one of the causative agents of bovine babesiosis, the most important tick-borne disease of cattle in tropical and subtropical regions. Babesia bovis has a complex life-cycle that includes sexual development within the tick vector. The development of a transmission blocking vaccine to control bovine babesiosis requires the identifica...

Effect of statins on inflammation and cardiac function in patients with chronic Chagas ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838836
PloS One; Campos-Estrada C, Urarte E et. al.

Jan 14th, 2023 - Cardiac complications, including heart failure and arrhythmias, are the leading causes of disability and death in Chagas disease (CD). CD, caused by the Trypanosoma cruzi parasite, afflicts 7 million people in Latin America, and its incidence is increasing in non-endemic countries due to migration. The cardiac involvement is explained by parasite-dependent, immune-mediated myocardial injury, mi...

Prevalence of Trypanosoma cruzi, the Etiologic Agent of Chagas Disease, Infection in Te...
https://doi.org/10.1089/vbz.2022.0056
Vector Borne and Zoonotic Diseases (Larchmont, N.Y.); Gulas-Wroblewski BE, Gorchakov R et. al.

Jan 13th, 2023 - Background: Chagas disease is one of the world's most neglected tropical diseases, infecting over six million people across the Americas. The hemoparasite Trypanosoma cruzi is the etiological agent for the disease, circulating in domestic, peridomestic, and sylvatic transmission cycles that are maintained by triatomine vectors and a diversity of wild and synanthropic hosts. Public health and wi...

Malnutrition-related parasite dissemination from the skin in visceral leishmaniasis is ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873180
PLoS Neglected Tropical Diseases; Osorio EY, Uscanga-Palomeque A et. al.

Jan 12th, 2023 - People are infected with Leishmania donovani when the parasite is deposited in the dermis during the blood meal of the sand fly vector. Most infected people develop a subclinical latent infection, but some develop progressive visceral leishmaniasis. Malnutrition is a risk factor for the development of active VL. We previously demonstrated increased parasite dissemination from the skin to viscer...

Cytokine and phenotypic cell profiles in human cutaneous leishmaniasis caused by Leishm...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815652
PloS One; Wijesooriya H, Samaranayake N et. al.

Jan 6th, 2023 - The innate immune mediators are likely to influence the clinical phenotype of leishmaniasis by primary responses which limit or facilitate the spread of the parasite, as well as by modulating adaptive immunity. This study investigated the response of key innate immune cells in a focus which regularly reports localised cutaneous leishmaniasis (LCL) caused by Leishmania donovani, a species which ...

Genetic variations in human ATP2B4 gene alter Plasmodium falciparum in vitro growth in ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817369
Malaria Journal; Joof F, Hartmann E et. al.

Jan 6th, 2023 - Polymorphisms in ATP2B4 coding for PMCA4b, the primary regulator of erythrocyte calcium concentration, have been shown by GWAS and cross-sectional studies to protect against severe malaria but the mechanism remains unknown. Using a recall-by-genotype design, we investigated the impact of a common haplotype variant in ATP2B4 using in vitro assays that model erythrocyte stage malaria pathogenesis...

Randomized, open-label, phase 2a study to evaluate the contribution of artefenomel to t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809015
Malaria Journal; Gansane A, Lingani M et. al.

Jan 4th, 2023 - The contribution of artefenomel to the clinical and parasiticidal activity of ferroquine and artefenomel in combination in uncomplicated Plasmodium falciparum malaria was investigated. This Phase 2a, randomized, open-label, parallel-group study was conducted from 11th September 2018 to 6th November 2019 across seven centres in Benin, Burkina Faso, Gabon, Kenya, and Uganda. Patients aged ≥ 14-69...

Burkitt lymphoma risk shows geographic and temporal associations with Plasmodium falcip...
https://doi.org/10.1073/pnas.2211055120
Proceedings of the National Academy of Sciences of the Un... Broen K, Dickens J et. al.

Jan 4th, 2023 - Endemic Burkitt lymphoma (eBL) is a pediatric cancer coendemic with malaria in sub-Saharan Africa, suggesting an etiological link between them. However, previous cross-sectional studies of limited geographic areas have not found a convincing association. We used spatially detailed data from the Epidemiology of Burkitt Lymphoma in East African Children and Minors (EMBLEM) study to assess this re...

AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes.
https://doi.org/10.1073/pnas.2210181120
Proceedings of the National Academy of Sciences of the Un... Marques-da-Silva C, Poudel B et. al.

Jan 4th, 2023 - Malaria, caused by Plasmodium parasites is a severe disease affecting millions of people around the world. Plasmodium undergoes obligatory development and replication in the hepatocytes, before initiating the life-threatening blood-stage of malaria. Although the natural immune responses impeding Plasmodium infection and development in the liver are key to controlling clinical malaria and transm...

PpSP32, the Phlebotomus papatasi immunodominant salivary protein, exerts immunomodulato...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806891
Parasites & Vectors; Souissi C, Marzouki S et. al.

Jan 3rd, 2023 - The saliva of sand flies, vectors of Leishmania parasites, contains several components that exert pharmacological activity facilitating the acquisition of blood by the insect and contributing to the establishment of infection. Previously, we demonstrated that PpSP32 is the immunodominant salivary antigen in humans exposed to Phlebotomus papatasi bites and validated its usefulness as a predictiv...

Pyrethroid insecticides pose greater risk than organophosphate insecticides to biocontr...
https://doi.org/10.1016/j.envpol.2022.120952
Environmental Pollution (Barking, Essex : 1987); Haggerty CJE, Delius BK et. al.

Jan 1st, 2023 - Use of agrochemicals, including insecticides, is vital to food production and predicted to increase 2-5 fold by 2050. Previous studies have shown a positive association between agriculture and the human infectious disease schistosomiasis, which is problematic as this parasitic disease infects approximately 250 million people worldwide. Certain insecticides might runoff fields and be highly toxi...

Survey of malaria vectors on the Cambodia, Thailand and China-Laos Borders.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801360
Malaria Journal; Zhang C, Yang R et. al.

Dec 31st, 2022 - Anopheles maculatus, Anopheles minimus and Anopheles dirus are the major vectors of malaria transmission in the Greater Mekong Subregion (GMS). The malaria burden in this region has decreased significantly in recent years as all GMS countries progress towards malaria elimination. It is necessary to investigate the Anopheles diversity and abundance status and assess the Plasmodium infection rate...

Malaria in Angola: recent progress, challenges and future opportunities using parasite ...
https://doi.org/10.1186/s12936-022-04424-y
Malaria Journal; Tavares W, Morais J et. al.

Dec 29th, 2022 - Over the past two decades, a considerable expansion of malaria interventions has occurred at the national level in Angola, together with cross-border initiatives and regional efforts in southern Africa. Currently, Angola aims to consolidate malaria control and to accelerate the transition from control to pre-elimination, along with other country members of the Elimination 8 initiative. However,...

Leishmania (L.) infantum chagasi isolated from skin lesions of patients affected by non...
https://doi.org/10.1016/j.parint.2022.102723
Parasitology International; Araujo Flores GV, Sandoval Pacheco CM et. al.

Dec 26th, 2022 - In Central America, Leishmania (L.) infantum chagasi infection causes visceral leishmaniasis (VL) and non-ulcerated cutaneous leishmaniasis (NUCL). The aim of the present study was to evaluate the course of an experimental infection in hamsters caused by L. (L.) infantum chagasi isolated from patients affected by NUCL compared with a strain isolated from a patient with VL. Stationary phase para...

Molecular surveillance of anti-malarial drug resistance genes in Plasmodium falciparum ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790123
Malaria Journal; Rana R, Khan N et. al.

Dec 25th, 2022 - Despite significant progress in eliminating malaria from the state of Odisha, India, the disease is still considered endemic. Artesunate plus sulfadoxine-pyrimethamine (AS + SP) has been introduced since 2010 as first-line treatment for uncomplicated Plasmodium falciparum malaria. This study aimed to investigate the prevalence of mutations associated with resistance to chloroquine (CQ), sulfado...