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About 23,915 results

The use of a chimeric antigen for Plasmodium falciparum and P. vivax seroprevalence est...
https://doi.org/10.1371/journal.pone.0263485
PloS One; McCaffery JN, Singh B et. al.

May 26th, 2022 - In low-transmission settings, accurate estimates of malaria transmission are needed to inform elimination targets. Detection of antimalarial antibodies provides exposure history, but previous studies have mainly relied on species-specific antigens. The use of chimeric antigens that include epitopes from multiple species of malaria parasites in population-based serological surveys could provide ...

Geographic Origin and Vertical Transmission of Leishmania infantum Parasites in Hunting...
https://doi.org/10.3201/eid2806.211746
Emerging Infectious Diseases; Franssen SU, Sanders MJ et. al.

May 25th, 2022 - Vertical transmission of leishmaniasis is common but is difficult to study against the background of pervasive vector transmission. We present genomic data from dogs in the United States infected with Leishmania infantum parasites; these infections have persisted in the apparent absence of vector transmission. We demonstrate that these parasites were introduced from the Old World separately and...

A new ferritin SjFer0 affecting the growth and development of Schistosoma japonicum.
https://doi.org/10.1186/s13071-022-05247-1 10.1016/0378-4274(95)03532-X 10.1002/mds.10650 10.1371/journal.pone.0098792 10.1016/j.cmet.2015.09.006 10.1016/j.cell.2016.12.034 10.1038/ng1658 10.1038/41343 10.1038/ng0897-383 10.1016/j.celrep.2015.09.023 10.1016/j.ebiom.2015.09.041 10.1016/S0891-5849(02)00842-0 10.1084/jem.20042433 10.1016/j.devcel.2008.12.002 10.1073/pnas.0606424103 10.1016/j.cmet.2011.08.015 10.1126/science.1157643 10.1038/nature04512 10.1073/pnas.0904519106 10.1039/C4CC07996E 10.1038/s41572-018-0013-8 10.2307/3282599 10.1074/jbc.M511148200 10.1371/journal.pntd.0000884 10.1111/febs.13368 10.1016/0166-6851(92)90221-5 10.1002/mrd.1080410307 10.1016/j.biocel.2007.04.017 10.1093/nar/gkx922 10.1016/j.molbiopara.2011.12.007 10.1007/978-1-0716-0635-3_3 10.1146/annurev.nutr.18.1.441 10.1016/j.ijpddr.2018.06.003 10.1093/bioinformatics/bty560 10.1093/bioinformatics/bts635 10.1186/1471-2105-12-1 10.1186/s13059-014-0550-8 10.1038/ncomms14693 10.1073/pnas.93.11.5624 10.3390/pathogens9060431 10.1007/s00436-016-5363-0 10.1016/S0960-9822(01)00118-X 10.1074/jbc.M600254200 10.1152/physrev.00030.2001 10.1111/febs.12700 10.1083/jcb.134.5.1179 10.1091/mbc.10.7.2329 10.1242/jcs.000695 10.1002/cm.21106 10.1016/j.diabres.2006.09.012 10.1016/S0021-9258(18)68398-X 10.1038/nchembio807 10.1111/j.1432-1033.1996.0064t.x 10.1074/jbc.M210333200 10.1074/jbc.M707043200 10.1371/journal.pgen.1002394 10.1016/j.cell.2012.03.042 10.1038/cdd.2015.158 10.1016/j.chembiol.2008.02.010
Parasites & Vectors; Zeng F, Yi C et. al.

May 25th, 2022 - Schistosomiasis, an acute and chronic parasitic disease, causes substantial morbidity and mortality in tropical and subtropical regions of the world. Iron is an essential constituent of numerous macromolecules involving in important cellular reactions in virtually all organisms. Trematodes of the genus Schistosoma live in iron-rich blood, feed on red blood cells and store abundant iron in vitel...

Human tumor necrosis factor alpha affects the egg-laying dynamics and glucose metabolis...
https://doi.org/10.1186/s13071-022-05278-8 10.1016/j.idc.2012.03.004 10.1186/1756-3305-4-203 10.1016/S0962-8924(01)02064-5 10.1038/356604a0 10.1016/S0742-8413(96)00137-5 10.1017/S0022149X00016291 10.1128/IAI.67.5.2201-2208.1999 10.1016/j.ijpara.2003.10.010 10.1371/journal.pntd.0000556 10.1007/s00436-015-4812-5 10.1515/ap-2017-0019 10.1128/JVI.77.13.7261-7280.2003 10.2307/3001913 10.1177/00164402062003002 10.1371/journal.ppat.1007817 10.1016/1043-4666(94)90003-5 10.1016/j.tibtech.2018.12.002 10.1373/clinchem.2008.112797 10.1371/journal.pbio.3000254
Parasites & Vectors; Lopes-Junior EH, Bertevello CR et. al.

May 25th, 2022 - Several studies have described the effects of human tumor necrosis factor alpha (hTNF-α) on Schistosoma mansoni. hTNF-α affects the worm's development, metabolism, egg-laying, gene expression and protein phosphorylation. The available data on the influence of hTNF-α on egg-laying in S. mansoni are controversial, but understanding the mechanism of egg-laying regulation in this species is essenti...

Genetic diversity and population structure of Leishmania (Viannia) braziliensis in the ...
https://doi.org/10.1371/journal.pntd.0010374
PLoS Neglected Tropical Diseases; De Los Santos MB, Ramírez IM et. al.

May 24th, 2022 - Human cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis is highly prevalent in the Peruvian jungle, where it affects military forces deployed to fight against drug trafficking and civilian people that migrate from the highland to the lowland jungle for economic activities such as mining, agriculture, construction, and chestnut harvest. We explored the genetic diversity and pop...

Characterization of a novel microfilarial antigen for diagnosis of Wuchereria bancrofti...
https://doi.org/10.1371/journal.pntd.0010407
PLoS Neglected Tropical Diseases; Greene SE, Fischer K et. al.

May 24th, 2022 - Lymphatic filariasis (LF) is a neglected tropical disease caused by the filarial nematodes Wuchereria bancrofti, Brugia malayi and Brugia timori. The Global Program to Eliminate LF uses mass drug administration (MDA) of anti-filarial drugs that clear microfilariae (Mf) from blood to interrupt transmission by mosquitos. New diagnostic tools are needed to assess the impact of MDA on bancroftian f...

Diurnal biting of malaria mosquitoes in the Central African Republic indicates residual...
https://doi.org/10.1073/pnas.2104282119
Proceedings of the National Academy of Sciences of the Un... Sangbakembi-Ngounou C, Costantini C et. al.

May 17th, 2022 - SignificanceTransmission of malarial parasites occurs via the bites of Anopheles mosquitoes, whose blood-feeding behavior modulates the risk of infection. In many malaria endemic regions, eradication strategies rely on reducing transmission by targeting nocturnal blood-feeding Anopheles with insecticidal nets. However, a proportion of mosquitoes may naturally feed when humans are not protected ...

Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibito...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107587
Malaria Journal; Khandelwal A, Arez F et. al.

May 16th, 2022 - Targeting the asymptomatic liver stage of Plasmodium infection through chemoprevention could become a key intervention to reduce malaria-associated incidence and mortality. M5717, a Plasmodium elongation factor 2 inhibitor, was assessed in vitro and in vivo with readily accessible Plasmodium berghei parasites. In an animal refinement, reduction, replacement approach, the in vitro IC99 value was...

Exo-erythrocytic development of Plasmodium matutinum (lineage pLINN1) in a naturally in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107739
Malaria Journal; Pendl H, Hernández-Lara C et. al.

May 16th, 2022 - Species of Plasmodium (Haemosporida, Plasmodiidae) are remarkably diverse haemoparasites. Information on genetic diversity of avian malaria pathogens has been accumulating rapidly, however exo-erythrocytic development of these organisms remains insufficiently addressed. This is unfortunate because, contrary to Plasmodium species parasitizing mammals, the avian malaria parasites undergo several ...

The monoterpene 1,8-cineole prevents cerebral edema in a murine model of severe malaria.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098050
PloS One; Santos ECD, Silva LS et. al.

May 14th, 2022 - 1,8-Cineole is a naturally occurring compound found in essential oils of different plants and has well-known anti-inflammatory and antimicrobial activities. In the present work, we aimed to investigate its potential antimalarial effect, using the following experimental models: (1) the erythrocytic cycle of Plasmodium falciparum; (2) an adhesion assay using brain microvascular endothelial cells;...

Occupational risk of cutaneous larva migrans: A case report and a systematic literature...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098051
PLoS Neglected Tropical Diseases; Stufano A, Foti C et. al.

May 14th, 2022 - Cutaneous larva migrans (CLM) is a parasitic zoonosis of warm tropical and subtropical areas, although autochthonous cases have been increasingly reported in Western European countries. Data on the prevalence of CLM as an occupational disease in workers exposed to potentially contaminated soil or in close contact with dogs and cats are scant. Herein, we report an autochthonous case of CLM in a ...

Can floral nectars reduce transmission of Leishmania?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098005
PLoS Neglected Tropical Diseases; Palmer-Young EC, Schwarz RS et. al.

May 14th, 2022 - Insect-vectored Leishmania are responsible for loss of more disability-adjusted life years than any parasite besides malaria. Elucidation of the environmental factors that affect parasite transmission by vectors is essential to develop sustainable methods of parasite control that do not have off-target effects on beneficial insects or environmental health. Many phytochemicals that inhibit growt...

Dirofilaria immitis antigenemia and microfilaremia in Iberian wolves and red foxes from...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082910
Parasites & Vectors; Gomes-de-Sá S, Santos-Silva S et. al.

May 9th, 2022 - Dirofilaria immitis is a parasitic nematode endemic in the Mediterranean countries, which causes cardiopulmonary dirofilariosis in wild and domestic animals. Despite being recognized hosts of D. immitis, wild carnivores such as wolves and foxes are frequently disregarded when considering a potential role in the transmission of these zoonotic nematodes. In Portugal, studies available regarding D...

Why Plasmodium vivax and Plasmodium falciparum are so different? A tale of two clades a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066883
Malaria Journal; Escalante AA, Cepeda AS et. al.

May 4th, 2022 - The global malaria burden sometimes obscures that the genus Plasmodium comprises diverse clades with lineages that independently gave origin to the extant human parasites. Indeed, the differences between the human malaria parasites were highlighted in the classical taxonomy by dividing them into two subgenera, the subgenus Plasmodium, which included all the human parasites but Plasmodium falcip...

Evolutionary history of Plasmodium vivax and Plasmodium simium in the Americas.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066938
Malaria Journal; Rougeron V, Daron J et. al.

May 4th, 2022 - Malaria is a vector-borne disease caused by protozoan parasites of the genus Plasmodium. Plasmodium vivax is the most prevalent human-infecting species in the Americas. However, the origins of this parasite in this continent are still debated. Similarly, it is now accepted that the existence of Plasmodium simium is explained by a P. vivax transfer from humans to monkey in America. However, many...

The primate malaria parasites Plasmodium malariae, Plasmodium brasilianum and Plasmodiu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066925
Malaria Journal; Fuehrer HP, Campino S et. al.

May 4th, 2022 - During the twentieth century, there was an explosion in understanding of the malaria parasites infecting humans and wild primates. This was built on three main data sources: from detailed descriptive morphology, from observational histories of induced infections in captive primates, syphilis patients, prison inmates and volunteers, and from clinical and epidemiological studies in the field. All...

Plasmodium knowlesi: the game changer for malaria eradication.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066973
Malaria Journal; Lee WC, Cheong FW et. al.

May 4th, 2022 - Plasmodium knowlesi is a zoonotic malaria parasite that has gained increasing medical interest over the past two decades. This zoonotic parasitic infection is prevalent in Southeast Asia and causes many cases with fulminant pathology. Despite several biogeographical restrictions that limit its distribution, knowlesi malaria cases have been reported in different parts of the world due to travell...

Artesunate-amodiaquine and artemether-lumefantrine for the treatment of uncomplicated f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044686
Malaria Journal; Koko VS, Warsame M et. al.

Apr 29th, 2022 - Artesunate-amodiaquine (ASAQ) and Artemether-lumefantrine (AL) are the recommended treatment for uncomplicated Plasmodium falciparum malaria in Liberia. Intermittent preventive treatment with sulfadoxine/pyrimethamine is also recommended for pregnant women. The therapeutic efficacy of Artesunate-amodiaquine and Artemether-lumefantrine, and the frequency of molecular markers associated with anti...

Essential Bromodomain TcBDF2 as a Drug Target against Chagas Disease.
https://doi.org/10.1021/acsinfecdis.2c00057
ACS Infectious Diseases; Pezza A, Tavernelli LE et. al.

Apr 29th, 2022 - Trypanosoma cruzi is a unicellular parasite that causes Chagas disease, which is endemic in the American continent but also worldwide, distributed by migratory movements. A striking feature of trypanosomatids is the polycistronic transcription associated with post-transcriptional mechanisms that regulate the levels of translatable mRNA. In this context, epigenetic regulatory mechanisms have bee...

Prevalence of Strongyloides stercoralis infection and associated clinical symptoms amon...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049318
PLoS Neglected Tropical Diseases; Jember TH, Amor A et. al.

Apr 29th, 2022 - Strongyloides stercoralis is a parasite that causes strongyloidiasis in humans. It is prevalent in the tropics and sub-tropics where poor sanitation is a common problem. The true prevalence of S. stercoralis in Ethiopia is underestimated due to the lack of a "Gold" standard diagnostic method. Moreover, its prevalence across altitudinal gradient in Amhara Region has not been studied. A cross-sec...