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About 24,463 results

Diversity and behavioral activity of Anopheles mosquitoes on the slopes of Mount Cameroon.
https://doi.org/10.1186/s13071-022-05472-8
Parasites & Vectors; Kwi PN, Ewane EE et. al.

Sep 29th, 2022 - Malaria remains endemic in Cameroon, with heterogeneous transmission related to eco-climatic variations, vector diversity and spatial distribution. The intensification of malaria prevention and control through the free distribution of insecticide-treated nets in recent years may have altered the composition, geographic distribution and natural infection rate of Anopheles species, with implicati...

Influence of landscape heterogeneity on entomological and parasitological indices of ma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516797
Parasites & Vectors; Otambo WO, Onyango PO et. al.

Sep 28th, 2022 - Identification and characterization of larval habitats, documentation of Anopheles spp. composition and abundance, and Plasmodium spp. infection burden are critical components of integrated vector management. The present study aimed to investigate the effect of landscape heterogeneity on entomological and parasitological indices of malaria in western Kenya. A cross-sectional entomological and p...

Quality of life of cutaneous leishmaniasis suspected patients in the Ecuadorian Pacific...
https://doi.org/10.1186/s12879-022-07733-4
BMC Infectious Diseases; Bezemer JM, Hinojosa MC et. al.

Sep 25th, 2022 - Yearly, up to 1 million patients worldwide suffer from cutaneous leishmaniasis (CL). In Ecuador, CL affects an estimated 5000 patients annually. CL leads to reduced Health Related Quality of Life (HRQL) as a result of stigma in the Asian and Mediterranean contexts, but research is lacking for Ecuador. The objective of this study was to explore the influence of CL suspected lesions on the qualit...

Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509318
Nature Communications; Ko KT, Lennartz F et. al.

Sep 25th, 2022 - An effective malaria vaccine remains a global health priority and vaccine immunogens which prevent transmission of the parasite will have important roles in multi-component vaccines. One of the most promising candidates for inclusion in a transmission-blocking malaria vaccine is the gamete surface protein Pfs48/45, which is essential for development of the parasite in the mosquito midgut. Indee...

Agreement among rapid diagnostic tests, urine malaria tests, and microscopy in malaria ...
https://doi.org/10.1177/03000605221122740
The Journal of International Medical Research; Oyeniyi JA, Bello IS et. al.

Sep 21st, 2022 - We determined the malaria prevalence and ascertained the degree of agreement among rapid diagnostic tests (RDTs), urine malaria tests, and microscopy in malaria diagnosis of adults in Nigeria. This was a cross-sectional study among 384 consenting patients recruited at a tertiary health facility in southwestern Nigeria. We used standardized interviewer-administered questionnaires to collect pati...

Spatiotemporal variation of malaria incidence in parasite clearance interventions and n...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484658
PloS One; Zeleke MT, Gelaye KA et. al.

Sep 20th, 2022 - In Ethiopia, malaria remains a major public health problem. To eliminate malaria, parasite clearance interventions were implemented in six kebeles (the lowest administrative unit) in the Amhara region. Understanding the spatiotemporal distribution of malaria is essential for targeting appropriate parasite clearance interventions to achieve the elimination goal. However, little is known about th...

Large-scale and small-scale population genetic structure of the medically important gas...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484234
Parasites & Vectors; Maes T, De Corte Z et. al.

Sep 20th, 2022 - Gastropod snails remain strongly understudied, despite their important role in transmitting parasitic diseases. Knowledge of their distribution and population dynamics increases our understanding of the processes driving disease transmission. We report the first study to use high-throughput sequencing (HTS) to elucidate the population genetic structure of the hermaphroditic snail Bulinus trunca...

Keys to the avian Haemoproteus parasites (Haemosporida, Haemoproteidae).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487097
Malaria Journal; Valkiūnas G, Iezhova TA

Sep 20th, 2022 - Haemoproteus is a sister genus to malaria parasites (Plasmodium), which both belong to the order Haemosporida (Apicomplexa). Parasites of both genera are flourishing in birds, however, Haemoproteus species are noticeably less investigated. This is unfortunate because knowledge about close relatives of malaria pathogens is important for better understanding the evolutionary origin and basic biol...

Repurposing of the Malaria Box for Babesia microti in mice identifies novel active scaf...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487043
Parasites & Vectors; Rizk MA, Baghdadi HB et. al.

Sep 20th, 2022 - An innovative approach has been introduced for identifying and developing novel potent and safe anti-Babesia and anti-Theileria agents for the control of animal piroplasmosis. In the present study, we evaluated the inhibitory effects of Malaria Box (MBox) compounds (n = 8) against the growth of Babesia microti in mice and conducted bioinformatics analysis between the selected hits and the curre...

Temporal dynamics of Plasmodium falciparum population in Metehara, east-central Ethiopia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479295
Malaria Journal; Reda AG, Messele A et. al.

Sep 16th, 2022 - Plasmodium falciparum is the most serious, genetically most complex and fastest-evolving malaria parasite. Information on genetic diversity of this parasite would guide policy decision and malaria elimination endeavors. This study explored the temporal dynamics of P. falciparum population in two time points in Metehara, east-central Ethiopia. The participants were quantitative real-time polymer...

Temporal trends in molecular markers of drug resistance in Plasmodium falciparum in hum...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472345
Malaria Journal; Zhou Z, Gimnig JE et. al.

Sep 14th, 2022 - Over the last two decades, the scale-up of vector control and changes in the first-line anti-malarial, from chloroquine (CQ) to sulfadoxine-pyrimethamine (SP) and then to artemether-lumefantrine (AL), have resulted in significant decreases in malaria burden in western Kenya. This study evaluated the long-term effects of control interventions on molecular markers of Plasmodium falciparum drug re...

Schistosoma mansoni phosphoglycerate mutase: a glycolytic ectoenzyme with thrombolytic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461710
Parasite (Paris, France); Pirovich DB, Da'dara AA et. al.

Sep 10th, 2022 - Schistosomiasis is a debilitating parasitic disease caused by intravascular flatworms called schistosomes (blood flukes) that affects >200 million people worldwide. Proteomic analysis has revealed the surprising presence of classical glycolytic enzymes - typically cytosolic proteins - located on the extracellular surface of the parasite tegument (skin). Immunolocalization experiments show that ...

Effects of negative air ions (NAIs) on Leishmania major: A novel tool for treatment of ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455840
PloS One; Badirzadeh A, Najm M et. al.

Sep 9th, 2022 - Cutaneous leishmaniasis (CL) is a Neglected Tropical Disease (NTD) that causes high morbidity in the tropics and sub-tropics. Despite the remarkable advancements in the treatment of CL, the available therapeutics are far from ideal and also cause serious adverse side effects. Negative air ions (NAIs) generators are widely available for domestic and industrial uses. Several studies have reported...

Efficacy of three anti-malarial regimens for uncomplicated Plasmodium falciparum malari...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450427
Malaria Journal; Lek D, Rachmat A et. al.

Sep 8th, 2022 - Anti-malarial resistance remains an important public health challenge in Cambodia. The effectiveness of three therapies for uncomplicated falciparum malaria was evaluated in Oddar Meanchey province in Northern Cambodia from 2009 to 2011. In this randomized, open-label, parallel group-controlled trial, 211 subjects at least 5 years old with uncomplicated falciparum malaria were treated with 3 da...

Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chaga...
https://doi.org/10.1038/s41564-022-01211-y
Nature Microbiology; Padilla AM, Wang W et. al.

Sep 7th, 2022 - Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The options for treatment and prevention of Chagas disease are limited and underutilized. Here we describe the discovery of a series of benzoxaborole compounds with nanomolar activity against extra- and intracellular stages of T. cruzi. Levera...

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes.
https://doi.org/10.3791/63987
Journal of Visualized Experiments : JoVE; de Lacerda L, Castro G et. al.

Sep 6th, 2022 - Malaria is a major public health concern, presenting more than 200 million cases per year worldwide. Despite years of scientific efforts, protective immunity to malaria is still poorly understood, mainly due to methodological limitations of long-term Plasmodium culture, especially for Plasmodium vivax. Most studies have focused on adaptive immunity protection against malaria by antibodies, whic...

The non-glycosylated protein of Toxocara canis MUC-1 interacts with proteins of murine ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477421
PLoS Neglected Tropical Diseases; Zhou R, Jia H et. al.

Sep 3rd, 2022 - Toxocariasis is a neglected parasitic disease caused predominantly by larvae of Toxocara canis. While this zoonotic disease is of major importance in humans and canids, it can also affect a range of other mammalian hosts. It is known that mucins secreted by larvae play key roles in immune recognition and evasion, but very little is understood about the molecular interactions between host cells ...

The in vivo RNA structurome of the malaria parasite Plasmodium falciparum, a protozoan ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436142
PloS One; Dumetz F, Enright AJ et. al.

Sep 2nd, 2022 - Plasmodium falciparum, a protozoan parasite and causative agent of human malaria, has one of the most A/T-biased genomes sequenced to date. This may give the genome and the transcriptome unusual structural features. Recent progress in sequencing techniques has made it possible to study the secondary structures of RNA molecules at the transcriptomic level. Thus, in this study we produced the in ...

Burden of malaria infection among individuals of varied blood groups in Kenya.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438094
Malaria Journal; Yeda R, Okudo C et. al.

Sep 2nd, 2022 - The ABO blood groups consist of A, B, and H carbohydrate antigens, which regulate protein activities during malaria infection in humans. Understanding the interplay between the malaria parasite and blood group antigens is essential in understanding new interventions to reduce the global burden of malaria. This study assessed the burden of malaria infection among individuals with varying blood g...

Potential application of the haematology analyser XN-31 prototype for field malaria sur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434510
Malaria Journal; Kagaya W, Takehara I et. al.

Sep 2nd, 2022 - Simple and accurate diagnosis is a key component of malaria control programmes. Microscopy is the current gold standard, however it requires extensive training and the results largely rely on the skill of the microscopists. Malaria rapid diagnostic tests (RDT) can be performed with minimal training and offer timely diagnosis, but results are not quantitative. Moreover, some Plasmodium falciparu...