Parasites & Vectors; Flegr J
Sep 30th, 2021 - Latent toxoplasmosis, i.e. a lifelong infection with the protozoan parasite Toxoplasma gondii, affects about a third of the human population worldwide. In the past 10 years, numerous studies have shown that infected individuals have a significantly higher incidence of mental and physical health problems and are more prone to exhibiting the adverse effects of various diseases. A cross-sectional ...
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Nature Medicine; Oneko M, Steinhardt LC et. al.
Sep 15th, 2021 - The radiation-attenuated Plasmodium falciparum sporozoite (PfSPZ) vaccine provides protection against P. falciparum infection in malaria-naïve adults. Preclinical studies show that T cell-mediated immunity is required for protection and is readily induced in humans after vaccination. However, previous malaria exposure can limit immune responses and vaccine efficacy (VE) in adults. We hypothesiz...
https://doi.org/10.1038/s41591-021-01492-6 10.1016/S0140-6736(17)33080-5 10.1016/S0140-6736(21)00943-0 10.1038/s41586-021-03684-z
Nature Medicine; Alonso PL
Sep 15th, 2021 - Malaria: a problem to be solved and a time to be bold.|2021|Alonso PL,|economics,economics,epidemiology,parasitology,prevention & control,economics,economics,
Aug 29th, 2021 - COVID-19 and malaria, a tale of two diseases.|2021|EBioMedicine ,|analysis,diagnosis,virology,analysis,genetics,diagnosis,parasitology,isolation & purification,metabolism,analysis,isolation & purification,metabolism,
Nature Microbiology; Tintó-Font E, Michel-Todó L et. al.
Aug 18th, 2021 - Periodic fever is a characteristic clinical feature of human malaria, but how parasites survive febrile episodes is not known. Although the genomes of Plasmodium species encode a full set of chaperones, they lack the conserved eukaryotic transcription factor HSF1, which activates the expression of chaperones following heat shock. Here, we show that PfAP2-HS, a transcription factor in the ApiAP2...
Journal of Immunology (Baltimore, Md. : 1950); Ghazanfari N, Gregory JL et. al.
Aug 18th, 2021 - In the Plasmodium berghei ANKA mouse model of malaria, accumulation of CD8+ T cells and infected RBCs in the brain promotes the development of experimental cerebral malaria (ECM). In this study, we used malaria-specific transgenic CD4+ and CD8+ T cells to track evolution of T cell immunity during the acute and memory phases of P. berghei ANKA infection. Using a combination of techniques, includ...
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Parasitology Research; Ng-Nguyen D, Van Nguyen T et. al.
Aug 14th, 2021 - Taenia hydatigena is a globally distributed canine tapeworm. The canine tapeworm results in economic impacts for farmers owing to organ condemnation. T. hydatigena utilizes dogs and other carnivores as definitive hosts while swine and ruminants serve as intermediate hosts. T. hydatigena is endemic in Vietnam; however, information on the prevalence and risk factors associated with infection is s...
Nature Communications; Ofir-Birin Y, Ben Ami Pilo H et. al.
Aug 13th, 2021 - Pathogens are thought to use host molecular cues to control when to initiate life-cycle transitions, but these signals are mostly unknown, particularly for the parasitic disease malaria caused by Plasmodium falciparum. The chemokine CXCL10 is present at high levels in fatal cases of cerebral malaria patients, but is reduced in patients who survive and do not have complications. Here we show a P...
Nature Communications; Boltryk SD, Passecker A et. al.
Aug 12th, 2021 - The malaria parasite Plasmodium falciparum replicates inside erythrocytes in the blood of infected humans. During each replication cycle, a small proportion of parasites commits to sexual development and differentiates into gametocytes, which are essential for parasite transmission via the mosquito vector. Detailed molecular investigation of gametocyte biology and transmission has been hampered...
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Parasitology Research; Lima AKC, Elias CGR et. al.
Aug 8th, 2021 - Leishmaniasis, included in the priority list of the WHO, remains as a neglected disease caused by parasites of the Leishmania genus. There is no vaccine available for human leishmaniasis, and the current treatment is based on old drugs that cause serious side effects. Herein, we initially studied the cellular distribution of the virulence factor gp63, the major metallopeptidase, in a virulent s...
Parasitology Research; Diehl MLN, Paes J et. al.
Aug 6th, 2021 - Acanthamoeba spp. are among the most worldwide prevalent protozoa. It is the causative agent of a disease known as Acanthamoeba keratitis, a painful and severe sight-threatening corneal infection that can lead to blindness. In recent years, the prevalence of Acanthamoeba keratitis has rapidly increased, growing its importance to human health. This systematic review aims to assess the distributi...
BMC Infectious Diseases; Mottaghipisheh H, Kalantar K et. al.
Aug 4th, 2021 - Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive inflammation. We aimed to describe the clinical and laboratory findings of HLH patients secondary to Visceral leishmaniasis (VL) and their treatment outcome during a 4-year follow-up period compared to primary HLH. Forty children with primary HLH confirmed by genetic study and 20 children with HLH secondary to VL confirmed by a...
Nature Communications; Thomson-Luque R, Votborg-Novél L et. al.
Aug 1st, 2021 - Following Plasmodium falciparum infection, individuals can remain asymptomatic, present with mild fever in uncomplicated malaria cases, or show one or more severe malaria symptoms. Several studies have investigated associations between parasite transcription and clinical severity, but no broad conclusions have yet been drawn. Here, we apply a series of bioinformatic approaches based on P. falci...
PLoS Pathogens; Saini E, Sheokand PK et. al.
Jul 30th, 2021 - The human malaria parasite, Plasmodium falciparum possesses unique gliding machinery referred to as the glideosome that powers its entry into the insect and vertebrate hosts. Several parasite proteins including Photosensitized INA-labelled protein 1 (PhIL1) have been shown to associate with glideosome machinery. Here we describe a novel PhIL1 associated protein complex that co-exists with the g...
Nature Communications; Zhang M, Wang C et. al.
Jul 29th, 2021 - The emergence and spread of Plasmodium falciparum parasites resistant to front-line antimalarial artemisinin-combination therapies (ACT) threatens to erase the considerable gains against the disease of the last decade. Here, we develop a large-scale phenotypic screening pipeline and use it to carry out a large-scale forward-genetic phenotype screen in P. falciparum to identify genes allowing pa...
PLoS Neglected Tropical Diseases; Chelbi I, Maghraoui K et. al.
Jul 28th, 2021 - The sand fly Phlebotomus perniciosus is the main vector of Leishmania infantum, etiological agent of zoonotic visceral leishmaniasis in the Western Mediterranean basin. Dogs are the main reservoir host of this disease. The main objective of this study was to determine, under both laboratory and field conditions, if dogs infected with L. infantum, were more attractive to female P. perniciosus th...
PLoS Neglected Tropical Diseases; Ojo JA, Adedokun SA et. al.
Jul 28th, 2021 - The risk of co-infection with Schistosoma haematobium and S. mansoni and the potential harmful effect on morbidity and control is enhanced by the overlapping distribution of both species in sub-Saharan Africa. Despite the reported high endemicity of both species in Nigeria, studies on the spread and effect of their mixed infection are limited. Therefore, a cross-sectional survey was conducted a...
PLoS Neglected Tropical Diseases; Rodrigues da Cunha GM, Azevedo MA et. al.
Jul 28th, 2021 - Chagas disease, caused by the parasite Trypanosoma cruzi, is considered endemic in more than 20 countries but lacks both an approved vaccine and limited treatment for its chronic stage. Chronic infection is most harmful to human health because of long-term parasitic infection of the heart. Here we show that immunization with a virus-like particle vaccine displaying a high density of the immunog...
PLoS Neglected Tropical Diseases; Heirwegh E, MacLean E et. al.
Jul 27th, 2021 - The leishmaniases are a group of sandfly-transmitted diseases caused by species of the protozoan parasite, Leishmania. With an annual incidence of 1 million cases, 1 billion people living in Leishmania-endemic regions, and nearly 30,000 deaths each year, leishmaniasis is a major global public health concern. While phlebotomine sandflies are well-known as vectors of Leishmania, they are also the...
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Nature Microbiology; Malleret B, El Sahili A et. al.
Jul 24th, 2021 - More than one-third of the world's population is exposed to Plasmodium vivax malaria, mainly in Asia1. P. vivax preferentially invades reticulocytes (immature red blood cells)2-4. Previous work has identified 11 parasite proteins involved in reticulocyte invasion, including erythrocyte binding protein 2 (ref. 5) and the reticulocyte-binding proteins (PvRBPs)6-10. PvRBP2b binds to the transferri...