×
About 21,760 results

Toxoplasmosis is a risk factor for acquiring SARS-CoV-2 infection and a severe course o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477627
Parasites & Vectors; Flegr J

Sep 30th, 2021 - Latent toxoplasmosis, i.e. a lifelong infection with the protozoan parasite Toxoplasma gondii, affects about a third of the human population worldwide. In the past 10 years, numerous studies have shown that infected individuals have a significantly higher incidence of mental and physical health problems and are more prone to exhibiting the adverse effects of various diseases. A cross-sectional ...

Safety, immunogenicity and efficacy of PfSPZ Vaccine against malaria in infants in west...
https://doi.org/10.1038/s41591-021-01470-y 10.1038/nature15535 10.1371/journal.pmed.1001685 10.1016/S0140-6736(15)60721-8 10.1016/S1473-3099(15)00239-X 10.1126/science.1241800 10.1038/nm.4110 10.1126/science.1211548 10.1073/pnas.1615324114 10.1038/nature21060 10.1126/science.1704150 10.1084/jem.151.6.1504 10.1073/pnas.85.2.573 10.4049/jimmunol.1700314 10.1016/S1473-3099(17)30104-4 10.1172/jci.insight.89154 10.4269/ajtmh.18-0835 10.4049/jimmunol.1202438 10.1371/journal.ppat.1002389 10.1186/s12936-019-2702-5 10.1038/s41598-017-10624-3 10.4049/jimmunol.172.3.1637 10.1038/s41591-018-0315-0 10.4269/ajtmh.17-1014 10.1111/j.1600-065X.2006.00479.x 10.1038/nri3384 10.1038/nri2781 10.1016/S0140-6736(72)90569-7 10.1093/infdis/153.4.763 10.1038/312449a0 10.1093/cid/ciz925 10.1186/1475-2875-10-223 10.1128/JCM.00565-14 10.1016/S0166-6851(01)00379-6 10.1016/j.jim.2016.08.009 10.1002/cyto.a.24189 10.1093/bioinformatics/btw191 10.1093/aje/kwh090 10.1214/aos/1176345976
Nature Medicine; Oneko M, Steinhardt LC et. al.

Sep 15th, 2021 - The radiation-attenuated Plasmodium falciparum sporozoite (PfSPZ) vaccine provides protection against P. falciparum infection in malaria-naïve adults. Preclinical studies show that T cell-mediated immunity is required for protection and is readily induced in humans after vaccination. However, previous malaria exposure can limit immune responses and vaccine efficacy (VE) in adults. We hypothesiz...

Malaria: a problem to be solved and a time to be bold.
https://doi.org/10.1038/s41591-021-01492-6 10.1016/S0140-6736(17)33080-5 10.1016/S0140-6736(21)00943-0 10.1038/s41586-021-03684-z
Nature Medicine; Alonso PL

Sep 15th, 2021 - Malaria: a problem to be solved and a time to be bold.|2021|Alonso PL,|economics,economics,epidemiology,parasitology,prevention & control,economics,economics,

COVID-19 and malaria, a tale of two diseases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382951
EBioMedicine EBioMedicine

Aug 29th, 2021 - COVID-19 and malaria, a tale of two diseases.|2021|EBioMedicine ,|analysis,diagnosis,virology,analysis,genetics,diagnosis,parasitology,isolation & purification,metabolism,analysis,isolation & purification,metabolism,

A heat-shock response regulated by the PfAP2-HS transcription factor protects human mal...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390444
Nature Microbiology; Tintó-Font E, Michel-Todó L et. al.

Aug 18th, 2021 - Periodic fever is a characteristic clinical feature of human malaria, but how parasites survive febrile episodes is not known. Although the genomes of Plasmodium species encode a full set of chaperones, they lack the conserved eukaryotic transcription factor HSF1, which activates the expression of chaperones following heat shock. Here, we show that PfAP2-HS, a transcription factor in the ApiAP2...

CD8+ and CD4+ T Cells Infiltrate into the Brain during Plasmodium berghei ANKA Infectio...
https://doi.org/10.4049/jimmunol.2000773
Journal of Immunology (Baltimore, Md. : 1950); Ghazanfari N, Gregory JL et. al.

Aug 18th, 2021 - In the Plasmodium berghei ANKA mouse model of malaria, accumulation of CD8+ T cells and infected RBCs in the brain promotes the development of experimental cerebral malaria (ECM). In this study, we used malaria-specific transgenic CD4+ and CD8+ T cells to track evolution of T cell immunity during the acute and memory phases of P. berghei ANKA infection. Using a combination of techniques, includ...

Prevalence and risk factors of Taenia hydatigena in dogs, pigs, and cattle in the Centr...
https://doi.org/10.1007/s00436-021-07276-8 10.4269/ajtmh.1996.54.352 10.22144/ctu.jvn.2018.095 10.18637/jss.v067.i01 10.1007/s11250-015-0892-6 10.1007/s10393-013-0884-9 10.4269/ajtmh.2012.11-0106 10.1186/s13071-020-04439-x 10.1016/S0001-706X(03)00058-5 10.1007/s10393-019-01392-9 10.4314/njpar.v38i1.6 10.18637/jss.v009.i08 10.3347/kjp.2020.58.1.93 10.1186/s13071-015-1015-y 10.1371/journal.pntd.0005743 10.1186/s13071-018-2945-y 10.1016/j.vetpar.2016.06.034 10.1016/j.actatropica.2016.11.010 10.1007/s11250-010-9537-y 10.1590/S0036-36341997000300009 10.1007/s00436-015-4532-x 10.1017/S0022149X14000601 10.1111/j.1365-3156.2005.01537.x 10.1017/S136898000725846X 10.1016/j.vetpar.2014.06.037 10.1186/s12879-019-4512-3
Parasitology Research; Ng-Nguyen D, Van Nguyen T et. al.

Aug 14th, 2021 - Taenia hydatigena is a globally distributed canine tapeworm. The canine tapeworm results in economic impacts for farmers owing to organ condemnation. T. hydatigena utilizes dogs and other carnivores as definitive hosts while swine and ruminants serve as intermediate hosts. T. hydatigena is endemic in Vietnam; however, information on the prevalence and risk factors associated with infection is s...

Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357946
Nature Communications; Ofir-Birin Y, Ben Ami Pilo H et. al.

Aug 13th, 2021 - Pathogens are thought to use host molecular cues to control when to initiate life-cycle transitions, but these signals are mostly unknown, particularly for the parasitic disease malaria caused by Plasmodium falciparum. The chemokine CXCL10 is present at high levels in fatal cases of cerebral malaria patients, but is reduced in patients who survive and do not have complications. Here we show a P...

CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasm...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355313
Nature Communications; Boltryk SD, Passecker A et. al.

Aug 12th, 2021 - The malaria parasite Plasmodium falciparum replicates inside erythrocytes in the blood of infected humans. During each replication cycle, a small proportion of parasites commits to sexual development and differentiates into gametocytes, which are essential for parasite transmission via the mosquito vector. Detailed molecular investigation of gametocyte biology and transmission has been hampered...

Anti-Leishmania braziliensis activity of 1,10-phenanthroline-5,6-dione and its Cu(II) a...
https://doi.org/10.1007/s00436-021-07265-x 10.1039/C6MT00133E 10.1371/journal.pntd.0004349.​g001 10.1371/journal.ppat.1007982 10.1016/j.cellimm.2016.07.013 10.1016/S0021-9258(19)69848-0 10.1006/abio.1993.1066 10.1073/pnas.83.1.100 10.1128/IAI.71.10.5739-5749.2003 10.1017/S0031182005008942 10.1016/j.actatropica.2008.03.005 10.3389/fcimb.2019.00319 10.1007/s00284-005-0222-8 10.3390/vetsci8020033 10.1023/B:BIOM.0000029438.97990.c6 10.1016/S0021-9258(18)67621-5 10.3389/fmicb.2019.01701 10.1126/scisignal.2000213 10.1016/0003-2697(80)90338-3 10.1371/journal.ppat.1004776 10.3389/fcimb.2012.00072 10.1016/S0166-6851(01)​00432-7 10.1074/jbc.M301451200 10.1007/s004360050417 10.1017/S0031182009990540 10.1016/S0021-9258(19)52451-6 10.1016/j.lfs.2019.01.015 10.1007/s10534-004-1229-5 10.1039/c2tx00010e 10.1128/MMBR.66.1.122-154.2002 10.1371/journal.pone.0163284 10.4103/ijpvm.IJPVM_116_18 10.1016/j.drudis.2010.10.005 10.1590/S0074-02762005000300017 10.1016/j.micinf.2012.05.014 10.1016/j.micinf.2010.07.010 10.2174/092986712800609788 10.1017/S0031182004006353 10.1590/S0001-37652006000400006 10.1016/j.ejop.2007.08.006 10.1016/0035-9203(81)90035-3 10.1016/j.protis.2017.03.004 10.1016/j.micinf.2006.01.006 10.1017/S003118201800152X 10.1007/s42770-020-00351-9 10.1093/jac/dkv292 10.2307/3279862 10.1242/jcs.113.24.4587 10.1128/IAI.00776-09 10.1016/s0166-6851(03)00211-1
Parasitology Research; Lima AKC, Elias CGR et. al.

Aug 8th, 2021 - Leishmaniasis, included in the priority list of the WHO, remains as a neglected disease caused by parasites of the Leishmania genus. There is no vaccine available for human leishmaniasis, and the current treatment is based on old drugs that cause serious side effects. Herein, we initially studied the cellular distribution of the virulence factor gp63, the major metallopeptidase, in a virulent s...

Genotype distribution of Acanthamoeba in keratitis: a systematic review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339388
Parasitology Research; Diehl MLN, Paes J et. al.

Aug 6th, 2021 - Acanthamoeba spp. are among the most worldwide prevalent protozoa. It is the causative agent of a disease known as Acanthamoeba keratitis, a painful and severe sight-threatening corneal infection that can lead to blindness. In recent years, the prevalence of Acanthamoeba keratitis has rapidly increased, growing its importance to human health. This systematic review aims to assess the distributi...

Comparison of the clinical features and outcome of children with hemophagocytic lymphoh...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330039
BMC Infectious Diseases; Mottaghipisheh H, Kalantar K et. al.

Aug 4th, 2021 - Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive inflammation. We aimed to describe the clinical and laboratory findings of HLH patients secondary to Visceral leishmaniasis (VL) and their treatment outcome during a 4-year follow-up period compared to primary HLH. Forty children with primary HLH confirmed by genetic study and 20 children with HLH secondary to VL confirmed by a...

Plasmodium falciparum transcription in different clinical presentations of malaria asso...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324851
Nature Communications; Thomson-Luque R, Votborg-Novél L et. al.

Aug 1st, 2021 - Following Plasmodium falciparum infection, individuals can remain asymptomatic, present with mild fever in uncomplicated malaria cases, or show one or more severe malaria symptoms. Several studies have investigated associations between parasite transcription and clinical severity, but no broad conclusions have yet been drawn. Here, we apply a series of bioinformatic approaches based on P. falci...

Plasmodium falciparum PhIL1-associated complex plays an essential role in merozoite reo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321122
PLoS Pathogens; Saini E, Sheokand PK et. al.

Jul 30th, 2021 - The human malaria parasite, Plasmodium falciparum possesses unique gliding machinery referred to as the glideosome that powers its entry into the insect and vertebrate hosts. Several parasite proteins including Photosensitized INA-labelled protein 1 (PhIL1) have been shown to associate with glideosome machinery. Here we describe a novel PhIL1 associated protein complex that co-exists with the g...

The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316339
Nature Communications; Zhang M, Wang C et. al.

Jul 29th, 2021 - The emergence and spread of Plasmodium falciparum parasites resistant to front-line antimalarial artemisinin-combination therapies (ACT) threatens to erase the considerable gains against the disease of the last decade. Here, we develop a large-scale phenotypic screening pipeline and use it to carry out a large-scale forward-genetic phenotype screen in P. falciparum to identify genes allowing pa...

Enhanced attraction of sand fly vectors of Leishmania infantum to dogs infected with zo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345872
PLoS Neglected Tropical Diseases; Chelbi I, Maghraoui K et. al.

Jul 28th, 2021 - The sand fly Phlebotomus perniciosus is the main vector of Leishmania infantum, etiological agent of zoonotic visceral leishmaniasis in the Western Mediterranean basin. Dogs are the main reservoir host of this disease. The main objective of this study was to determine, under both laboratory and field conditions, if dogs infected with L. infantum, were more attractive to female P. perniciosus th...

Prevalence of urogenital and intestinal schistosomiasis among school children in South-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345861
PLoS Neglected Tropical Diseases; Ojo JA, Adedokun SA et. al.

Jul 28th, 2021 - The risk of co-infection with Schistosoma haematobium and S. mansoni and the potential harmful effect on morbidity and control is enhanced by the overlapping distribution of both species in sub-Saharan Africa. Despite the reported high endemicity of both species in Nigeria, studies on the spread and effect of their mixed infection are limited. Therefore, a cross-sectional survey was conducted a...

α-Gal immunization positively impacts Trypanosoma cruzi colonization of heart tissue in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345864
PLoS Neglected Tropical Diseases; Rodrigues da Cunha GM, Azevedo MA et. al.

Jul 28th, 2021 - Chagas disease, caused by the parasite Trypanosoma cruzi, is considered endemic in more than 20 countries but lacks both an approved vaccine and limited treatment for its chronic stage. Chronic infection is most harmful to human health because of long-term parasitic infection of the heart. Here we show that immunization with a virus-like particle vaccine displaying a high density of the immunog...

Sandfly Fever Sicilian Virus-Leishmania major co-infection modulates innate inflammator...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341699
PLoS Neglected Tropical Diseases; Heirwegh E, MacLean E et. al.

Jul 27th, 2021 - The leishmaniases are a group of sandfly-transmitted diseases caused by species of the protozoan parasite, Leishmania. With an annual incidence of 1 million cases, 1 billion people living in Leishmania-endemic regions, and nearly 30,000 deaths each year, leishmaniasis is a major global public health concern. While phlebotomine sandflies are well-known as vectors of Leishmania, they are also the...

Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells.
https://doi.org/10.1038/s41564-021-00939-3 10.1016/0020-7519(88)90138-5 10.1182/blood-2014-08-596015 10.1371/journal.pntd.0002569 10.1038/nature07327 10.1038/srep26993 10.1038/s41598-018-28757-4 10.1093/infdis/jiy273 10.1128/IAI.00616-19 10.1126/science.aan1078 10.1371/journal.pone.0076062 10.1038/s41467-019-12294-3 10.1182/blood-2017-02-764787 10.1371/journal.ppat.1003943 10.1038/nature10606 10.4049/jimmunol.1302045 10.1084/jem.169.5.1795 10.1016/j.ijpara.2017.03.001 10.1093/infdis/jiaa592 10.1111/bjh.14976 10.1073/pnas.96.21.12079 10.1074/jbc.274.28.19745 10.1074/jbc.M704524200 10.1038/s41586-019-1011-z 10.1107/S2059798319009094 10.1038/s41594-019-0237-7 10.1182/blood-2011-04-348748 10.1016/0022-1759(85)90044-4 10.1371/journal.ppat.1003869 10.1073/pnas.1008151107 10.1371/journal.ppat.1004882 10.1128/mBio.00625-18 10.1016/0092-8674(92)90642-P 10.1073/pnas.1516512113 10.1371/journal.pntd.0005014 10.4269/ajtmh.2006.75.575 10.1073/pnas.0912496107 10.1016/j.trstmh.2007.04.011 10.1084/jem.180.2.497 10.1021/ac025747h 10.1021/ac0341261 10.1186/1475-2875-8-115 10.1046/j.1365-3148.2002.00373.x 10.1182/blood-2013-12-541698 10.1111/cmi.12608 10.3389/fmicb.2019.02236
Nature Microbiology; Malleret B, El Sahili A et. al.

Jul 24th, 2021 - More than one-third of the world's population is exposed to Plasmodium vivax malaria, mainly in Asia1. P. vivax preferentially invades reticulocytes (immature red blood cells)2-4. Previous work has identified 11 parasite proteins involved in reticulocyte invasion, including erythrocyte binding protein 2 (ref. 5) and the reticulocyte-binding proteins (PvRBPs)6-10. PvRBP2b binds to the transferri...