About 76,050 results

How to avoid the perils of uveitis diagnostic management

Jan 16th, 2022 - WAIKOLOA, Hawaii — It is important for physicians to consider “the perils that dwell” in the diagnostic management of patients with uveitis, Steven Yeh, MD, said during a presentation at Hawaiian Eye 2022. “With these patients being very complex oftentimes, we really just don’t want to miss something,” Yeh said. To better identify “the pearls amongst the perils” in uveitis diagnosis, it is impo...

TRIM21 as a Regulator of UVB-Driven IFN Responses in Lupus
Richard Moore, Gantsetseg Tumurkhuu, Daniel Wallace and Caroline Jefferies et. al.

Nov 14th, 2022 - Background/Purpose: Patients with systemic lupus erythematosus (SLE) experience photosensitivity where exposure to ultraviolet light B (UVB) drives lupus flares and systemic symptoms. Although the mechanisms linking UVB exposure to these effects are unclear, type I IFNs are known to play a role. TRIM21, an autoantigen in SLE, functions as a negative regulator on the pathways driving IFN express...

Current State and Completeness of Reporting Clinical Prediction Models Using Machine Learning in Systemic Lupus Erythematosus: A Systematic Review
Claudia Mendoza-Pinto, Ivet Etchegaray-Morales, Pamela Munguía-Realpozo et. al.

Nov 14th, 2022 - Background/Purpose: There is increased interest in machine learning (ML)-based prediction models in systemic lupus erythematosus (SLE). We made a systematic review of adherence in diagnostic and prognostic applications of ML in SLE using the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) Statement. Methods: A systematic review using 5 da...

Increased Brain Functional Connectivity to the Insula Is Associated with Nociplastic Pain in Psoriatic Arthritis
Flavia Sunzini, Kristian Stefanov, Salim Al-Wasity et. al.

Nov 14th, 2022 - Background/Purpose: Pain is a hallmark feature of psoriatic arthritis (PsA); however, its apparent multi-factorial nature makes it difficult for rheumatologists to assess and manage. Clinically, nociplastic processes appear to contribute to the PsA pain experience, as shown by frequent co-existing fibromyalgia (FM), a prototypical nociplastic pain disorder [1,2]. Yet there are no objective data...

Higher Matrix Metalloproteinase Levels Are Predictive of Incident Interstitial Lung Disease Among a Cohort of US Veterans with Rheumatoid Arthritis
Brent Luedders, Dana Ascherman, Joshua Baker et. al.

Nov 14th, 2022 - Background/Purpose: Matrix metalloproteinases (MMPs) degrade extracellular matrix and have been implicated to play a role in a number of fibrotic processes. Specifically, MMPs have been speculated to play a role in the pathogenesis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) as well as idiopathic pulmonary fibrosis (IPF), which shares historadiological features with RA...

In Vitro Response to Disease Modifying Antirheumatic Drugs Link Molecular Drug Target with Synovial Transcriptional Signature
Mads Brüner, Ulvi Ahmadov, Morten Aagaard Nielsen et. al.

Nov 14th, 2022 - Background/Purpose: Immune-mediated inflammatory arthritis (IMIA) is a group of diseases characterized by chronic synovitis including rheumatoid arthritis (RA), psoriatic arthritis (PsA), and spondyloarthritis (SpA). Some disease modifying antirheumatic drugs (DMARDs) have demonstrated efficacy in several of these diseases (e.g. TNFα inhibitors) while others have not (e.g. IL-17A inhibitors in ...

The Transcriptomic Landscape of Nephritic Kidneys Reveals Mechanisms for End Organ Resistance to Damage in Lupus-prone Mice
Andrea Daamen, Hongyang Wang, Prathyusha Bachali et. al.

Nov 14th, 2022 - Background/Purpose: Pathologic inflammation is a major driver of kidney damage in lupus nephritis (LN), but the immune mechanisms of disease progression and risk factors for end organ damage are poorly understood. Previous studies established the NZM2328 lupus-prone mouse strain as a model for human proliferative glomerulonephritis (GN). These studies determined that disease in female NZM2328 m...

Are Serological Protease-mediated Peptides of Tissue Remodeling and Inflammation the New Disease Activity Biomarkers in Psoriatic Arthritis Patients?
Solveig S. Groen, Signe Holm Nielsen, Anne-Christine Bay-Jensen et. al.

Nov 13th, 2022 - Background/Purpose: Inflammatory and degenerative processes in the joint tissues are hallmarks of patients with psoriatic arthritis (PsA). Here, proteases play a major role in remodeling of the extracellular matrix (ECM) where collagens are major structural components. During inflammation, proteolytic processing of the ECM leads to unique protease-mediated breakdown products of collagens and pr...

Cardiovascular and Oncologic Outocomes of Anti-TNF Alfa and JAK Inhibitors in Patients with Rheumatoid and Psoriatic Arthritis. Real World Data and Insights of BIOBADASAR 3.0 Registry
Alejandro Brigante, Rosana Quintana, Carolina Isnardi et. al.

Nov 13th, 2022 - Background/Purpose: Major adverse cardiovascular events (MACE) and neoplasms are a concern in autoimmune diseases. RA and PsA are diseases where inflammation plays a key role in the development of the disease and the production of short- and long-term damage. TNF alpha plays a significant role in inflammation and the JAK/STAT signaling pathway is an important regulatory signaling cascades of in...

Low Neutrophil Ectonucleotidase Activity Drives Neutrophil-Platelet Aggregation and Platelet Activation in Antiphospholipid Syndrome (APS)
Naveen Kumar S K, Claire Hoy, Srilakshmi Yalavarthi et. al.

Nov 13th, 2022 - Background/Purpose: By converting extracellular ATP into homeostatic adenosine, the ectonucleotidases CD39 (ATP to AMP) and CD73 (AMP to adenosine) dictate extracellular purinergic gradients and as such are critical players in the regulation of leukocyte and platelet functions. Insufficient activity of these homeostatic ectoenzymes has been associated with neutrophil-driven inflammation. Crosst...

Identification of Systemic Lupus Erythematosus Endotypes by Analysis of Inflammatory and Immunologic Gene Expression Signatures
Erika Hubbard, Prathyusha Bachali, Kathryn Kingsmore Allison et. al.

Nov 13th, 2022 - Background/Purpose: One of the hallmarks of SLE is clinical and molecular heterogeneity. Recent work has leveraged next-generation sequencing techniques to identify molecular signatures characteristic of subsets of patients’ disease. Here, we employed gene set variation analysis (GSVA) of informative gene modules coupled with machine learning techniques to identify molecular endotypes of SLE pa...

Predicting Outcomes in Macrophage Activation Syndrome (MAS): A Retrospective Study on 43 Consecutive Patients with MAS

Nov 13th, 2022 - Background/Purpose: Macrophage activation syndrome is a diagnosis along the spectrum of hemophagocytic lymphohistiocytosis (HLH) spectrum disorders. It is a rare, yet potentially fatal disease characterized by hyperferritinemia, coagulopathy and multisystem inflammation. Predictive biomarkers for outcomes in MAS are lacking and hence this study yearns to elucidate them. Activation of complement...

Identifying a Pain Signature in Classical Ehlers-Danlos Syndrome: Preliminary Results from Questionnaires and Experimental Pain Testing
Marlies Colman, Inge De Wandele, Lies Rombaut et. al.

Nov 13th, 2022 - Background/Purpose: Chronic pain is one of the most common complaints of individuals with Ehlers-Danlos syndrome (EDS) and the effects of the existing therapeutical modalities are at best only partially effective. The etiology and mechanisms of pain in EDS have barely been studied, and the current understanding of the underlying neural, molecular and cellular pathways is minimal. Classical EDS ...

Increase of Intercellular Adhesion Molecule-1 Linked to Lung Damage of Interstitial Lung Disease in Patients with Autoimmune Diseases
Veronica Pulito-Cueto, Sara Remuzgo-Martinez, Fernanda Genre et. al.

Nov 13th, 2022 - Background/Purpose: Intercellular adhesion molecule-1 (ICAM-1) regulates leukocyte recruitment from circulation to sites of inflammation, being considered as a marker of underlying endothelial damage [1]. Moreover, ICAM-1 contributes to the development of interstitial lung disease (ILD) and it has been proposed as a prognostic biomarker in idiopathic pulmonary fibrosis (IPF) [2]. Although ILD i...

Whole-Blood DNA Methylation Analysis Reveals Respiratory Environmental Traits Involved in COVID-19 Severity Following SARS-CoV-2 Infection and Common Molecular Signatures with Autoimmune Diseases
Guillermo Barturen, Elena Carnero-Montoro, Manuel Martinez-Bueno et. al.

Nov 13th, 2022 - Background/Purpose: SARS-CoV-2 causes a severe inflammatory syndrome (COVID-19) leading, in many cases, to bilateral pneumonia, severe dyspnea and in ~5% of these, death. DNA methylation is known to play an important role in the regulation of the immune processes behind COVID-19 progression, however it has not been studied in depth. In this study, we aimed at evaluating the implication of DNA m...

How Common Is the Coexistence of Juvenile Localized and Systemic Scleroderma? Results of a Multination Survey
Ivan Foeldvari, Nicola Helmus2 and Suzanne Li, Hamburger Zentrum für Kinder- und Jugendrheumatologie et. al.

Nov 13th, 2022 - Background/Purpose: Pediatric scleroderma consists of two diseases, juvenile localized scleroderma (jLS) and juvenile systemic sclerosis (jSSc). While jLS and jSSc share some disease processes, there are major differences in their clinical features and morbidity patterns. Co-existence of LS and SSc has been reported in adults, with a recent adult systematic review reporting a frequency of 2.4-7...

Differences in Chromatin Accessibility Pre- and Post-Induction Therapy in Pediatric Lupus
Joyce Hui-Yuen, Kaiyu Jiang, Susan Malkiel et. al.

Nov 13th, 2022 - Background/Purpose: Systemic lupus erythematosus (SLE) may be triggered by gene-environment interactions. Data are scarce on how epigenetic variance contributes to disease risk in pediatric SLE (pSLE). Our object was to identify differences in chromatin accessibility in treatment-naive pSLE compared to healthy children (HC) and pSLE patients post-induction therapy. Methods: We used assays for t...

Monocyte Chemoattractant Protein-1, Vascular Cell Adhesion Protein-1 and Asymmetric Dimethylarginine as Potential Biomarkers of Interstitial Lung Disease Associated with RA
Veronica Pulito-Cueto, Sara Remuzgo-Martinez, Fernanda Genre et. al.

Nov 12th, 2022 - Background/Purpose: Interstitial lung disease (ILD) is one of the main comorbidities of patients with RA contributing to an increased mortality risk [1]. The pathogenesis of RA-ILD remains poorly defined, constituting its early diagnosis a challenge for clinicians [1]. The endothelium plays a pivotal role in inflammatory diseases and in the pulmonary vascular regulation contributing to the deve...

Increase of Serum Endothelin-1 Levels in Patients with Interstitial Lung Disease Associated with Autoimmune Diseases
Sara Remuzgo-Martinez, Belén Atienza-Mateo, Veronica Pulito-Cueto et. al.

Nov 12th, 2022 - Background/Purpose: Interstitial lung disease (ILD) may occur in patients with a rheumatic autoimmune disease (AD), increasing their morbidity and mortality [1]. In this regard, the identification of serum biomarkers of AD-ILD is of potential interest. Endothelin-1 (ET-1) is a proinflammatory protein involved in multiple vascular and fibrosing abnormalities [2-3], characteristic processes of AD...

The Journey to Collaborative Care and Patient-Centric Educational Opportunities for a Scleroderma Patient
Amy Gietzen and Hannah Bowen, The Ann Steffens Scleroderma Foundation, Albany et. al.

Nov 12th, 2022 - Background/Purpose: In 2001 I started to experience forearm, elbow, and wrist pain. My fingers were constantly swollen, and sensitive. After 6 months of living in pain and stiffness, I sought out help. I was then diagnosed with Systemic Diffuse Scleroderma. I developed Interstitial Lung disease, hypertension and heart complications almost immediately. My skin became hard and tight. My hands con...