×
About 47,195 results

MicroRNAs and their implications in CD4+ T-cells, oligodendrocytes and dendritic cells ...
https://doi.org/10.2174/1566524022666220525150259
Current Molecular Medicine; Safari A, Madadi S et. al.

May 28th, 2022 - MicroRNAs (miRNAs) have been established as key players in various biological processes regulating differentiation, proliferation, inflammation, and autoimmune disorders. Emerging evidence suggests the critical role of miRNAs in the pathogenesis of multiple sclerosis (M.S.). Here, we provide a comprehensive overview on miRNAs which are differentially expressed in M.S. patients or experimental a...

Nucleophosmin 1: from its pathogenic role to a tantalizing therapeutic target in acute ...
https://doi.org/10.1080/16078454.2022.2067939
Hematology (Amsterdam, Netherlands); Shi Y, Xue Y et. al.

May 28th, 2022 - Nucleophosmin 1 (NPM1, also known as B23) is a multifunctional protein involved in a variety of cellular processes, including ribosomal maturation, centrosome replication, maintenance of genomic stability, cell cycle control, and apoptosis. NPM1 is the most commonly mutated gene in adult acute myeloid leukemia (AML) and is present in approximately 40% of all AML cases. The underlying mechanisms...

Social deficits in BTBR T+ Itpr3tf/J mice vary with ecological validity of the test.
https://doi.org/10.1111/gbb.12814
Genes, Brain, and Behavior; Winiarski M, Kondrakiewicz L et. al.

May 28th, 2022 - Translational value of mouse models of neuropsychiatric disorders depends heavily on the accuracy with which they replicate symptoms observed in the human population. In mouse models of autism spectrum disorder (ASD) these include, among others, social affiliation, and communication deficits as well as impairments in understanding and perception of others. Most studies addressing these issues i...

The Pathogenesis and Natural History of Sjogren s Syndrome
https://clinicaltrials.gov/ct2/show/NCT01425892

May 27th, 2022 - BACKGROUND Sj(SqrRoot)(Delta)gren s syndrome (SS) is an autoimmune disease characterized by chronic inflammation involving the exocrine glands. Salivary and lacrimal glands are predominantly affected leading to dry mouth and dry eyes but other exocrine organs are also frequently involved. It is one of the most common rheumatic autoimmune diseases, which effects between 1-4 million Americans, pr...

SARS-COV2 Pandemic Serosurvey in a Rare Disease Population
https://clinicaltrials.gov/ct2/show/NCT04609085

May 27th, 2022 - It has been demonstrated that respiratory virus outbreaks and pandemics, such as influenza, SARS, MERS, and now the newly emerged SARS-COV2 virus, have a major impact on morbidity and mortality worldwide, as well as having devastating global economic and societal impact. During these outbreaks it is critical to gain a rapid understanding of the exposures and immunity in the general population. ...

Sirolimus (Rapamune ) for Relapse Prevention in People With Severe Aplastic Anemia Responsive to Immunosuppressive Therapy
https://clinicaltrials.gov/ct2/show/NCT02979873

May 27th, 2022 - Most acquired aplastic anemia ensues from immune-mediated destruction of hematopoietic stem and progenitor cells. Immunosuppression is the definitive treatment of patients with acquired aplastic anemia who are not candidates for immediate hematopoietic stem cell transplantation. Horse ATG combined with the calcineurin inhibitor, cyclosporine (CsA), remains standard as first-line immunosuppressi...

Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation Disorders
https://clinicaltrials.gov/ct2/show/NCT00895271

May 27th, 2022 - This protocol is designed as an adjunct to other National Institutes of Health (NIH) IRB approved protocols that allow for genetic testing, which may include those that are screening protocols for patients with rare primary immunodeficiency or immunodysregulation disorders. Patients deemed of sufficient research interest after review of outside medical records, clinical evaluation, and testing,...

Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and TBI With Post-Transplant Cyclophosphamide
https://clinicaltrials.gov/ct2/show/NCT03910452

May 27th, 2022 - Allogeneic transplant using human leukocyte antigen (HLA) matched donors, both related and unrelated, has proven curative for patients with various immunodeficiencies, including those with ongoing infections. However, donor availability remains a limiting factor in the application of this treatment modality. For this protocol, a haploidentical donor is a related donor with more than 1 HLA antig...

Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute COVID-19 and Convalescence
https://clinicaltrials.gov/ct2/show/NCT04582903

May 27th, 2022 - In response to the public health emergency posed by the coronavirus disease 2019 (COVID-19) pandemic, researchers at the National Institute of Allergy and Infectious Diseases (NIAID) are leading a large international collaboration to characterize the innate and adaptive immune responses to acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and convalescence. This proto...

Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health
https://clinicaltrials.gov/ct2/show/NCT04573062

May 27th, 2022 - Study Description: In late 2019, the novel coronavirus SARS/CoV2 appeared in Wuhan, China. The various ways that humans will recover from COVID-19 is just starting to be observed and it is clear there will be a wide range of convalescent experiences. A year into the pandemic, the post-acute sequelae of SARS/CoV2 infection (PASC) is known to be common and includes a broad range of symptoms and p...

Studies in the Pathogenesis of Systemic Capillary Leak Syndrome
https://clinicaltrials.gov/ct2/show/NCT00936325

May 27th, 2022 - The systemic capillary leak syndrome (SCLS, Clarkson syndrome) is an exceedingly rare disorder of unknown cause characterized by chronic edema or acute transient, severe episodes of hypotension, hypovolemia, and oliguria. Severe edema results from leakage of fluid and macromolecules (200-900 kDa) into tissues. Acute SCLS episodes carry a high morbidity and mortality (25-30%). Fewer than 500 cas...

Pazopanib Effects on Bleeding in Hereditary Hemorrhagic Telangiectasia
https://clinicaltrials.gov/ct2/show/NCT03850964

May 27th, 2022 - Once a single dose pharmacokinetics (PK) study is performed to properly establish similar exposure with the prior pilot 50mg tablet, a double blind, placebo controlled study will follow (Part B), which proposes to define primarily the value of low dose (50 mg or 150 mg) Pazopanib on nose bleed duration, in the context of assessing perceived nose bleed severity. After a patient completes Part B ...

Idiopathic Pulmonary Arterial Hypertension Workup
http://emedicine.medscape.com/article/301450-workup

May 27th, 2022 - Approach Considerations Diagnostic algorithms can help in completing a thorough workup. In 2004, the American College of Chest Physicians (ACCP) published a consensus statement with diagnostic and treatment recommendations. [15, 16] In 2009, the American Heart Association (AHA) and the American College of Cardiology (ACC) published a joint guideline that provides extensive coverage of PAH diagn...

Natural History of Optic Neuritis
https://clinicaltrials.gov/ct2/show/NCT01851434

May 27th, 2022 - Objective The goals of this pilot study are: To assess the degree to which subacute changes in clinical, electrophysiological, and imaging measures can robustly predict retinal neuronal loss 12 months after acute optic neuritis. To construct a composite score that integrates these subacute changes, can itself robustly predict retinal neuronal loss 12 months after acute optic neuritis, can be va...

Rapid Autopsy and Procurement of Cancer Tissue
https://clinicaltrials.gov/ct2/show/NCT01851395

May 27th, 2022 - Background: Despite being the leading cause of cancer-related death worldwide, there is only limited knowledge of tumor heterogeneity in lung cancer. There is also limited knowledge of tumor heterogeneity of other less common thoracic malignancies, such as thymic epithelial tumors and mesothelioma. The extent and causes of intra-tumor and inter-metastatic heterogeneity in thoracic malignancies ...

Relating Genetic and Environmental Risk Scores to Multiple Sclerosis Susceptibility
https://clinicaltrials.gov/ct2/show/NCT01617395

May 27th, 2022 - Objective. The overall objective of this study is to investigate the genetic, immune, and neuroimaging profiles that may increase a person s risk of developing multiple sclerosis (MS) in order to identify and validate predictive biomarkers in populations at risk for this disorder. Study population. There will be three study populations: Individuals at risk for developing MS As part of the Genes...

Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung Disease
https://clinicaltrials.gov/ct2/show/NCT00368446

May 27th, 2022 - Background: Nontuberculous mycobacteria (NTM) are ubiquitous environmental organisms that have been increasingly associated with human disease, commonly involving the lung. Post menopausal Caucasian women seem particularly predisposed to the development of peripheral nodules and dilated airways (bronchiectasis) associated with these organisms. These women have distinguishing body characteristic...

Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment
https://clinicaltrials.gov/ct2/show/NCT01087333

May 27th, 2022 - Background Hairy cell leukemia (HCL) is highly responsive to but not curable by standard chemotherapy, and also responds well to investigational agents called recombinant immunotoxins which have been developed by the Laboratory of Molecular Biology (LMB). HCL variants often resemble classic HCL but are more aggressive and less responsive to treatments, such as HCLv and IGHV4-34+ HCL that are im...

Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions
https://clinicaltrials.gov/ct2/show/NCT03510442

May 27th, 2022 - The purpose of this protocol is to study the natural history, genetics and pathophysiology of systemic juvenile idiopathic arthritis (sJIA), adult-onset Still s disease (AOSD) and related inflammatory conditions. One of seven subtypes of juvenile idiopathic arthritis (JIA), sJIA contributes disproportionately to the morbidity and mortality of JIA and is considered by many to be the most severe ...

Pathological Basis of MRI Signal Changes in Multiple Sclerosis
https://clinicaltrials.gov/ct2/show/NCT02659956

May 27th, 2022 - Objective: The goal of this protocol is to understand how the pathology of multiple sclerosis (MS) relates to its evolution over time as observed through neuroradiological, clinical, and biological data collection in vivo. Study population: This study will enroll up to 150 individuals with MS, targeting 50 study completers, across various ages and stages of the disease, as well as 50 appropriat...