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About 37,270 results

Potential Implications of Mammalian Transient Receptor Potential Melastatin 7 in the Pa...
https://doi.org/10.3390/ijerph182010708
International Journal of Environmental Research and Publi... Du Preez S, Cabanas H et. al.

Oct 24th, 2021 - The transient receptor potential (TRP) superfamily of ion channels is involved in the molecular mechanisms that mediate neuroimmune interactions and activities. Recent advancements in neuroimmunology have identified a role for TRP cation channels in several neuroimmune disorders including amyotropic lateral sclerosis, multiple sclerosis, and myalgic encephalomyelitis/chronic fatigue syndrome (M...

Patients experiences with multiple sclerosis disease-modifying therapies in daily life ...
https://doi.org/10.1186/s12913-021-07012-z 10.3389/fneur.2018.01150 10.1177/1352458517690271 10.7224/1537-2073.2016-091 10.1371/journal.pone.0182806 10.1136/bmjopen-2016-013401 10.1016/j.msard.2018.11.016 10.1177/1049732316665347 10.1186/1471-2377-13-37 10.1177/1049732314523840 10.1191/1478088706qp063oa 10.1177/1049732318796831 10.1080/17482631.2019.1648946 10.2147/PPA.S115090 10.1177/0272989X19897944 10.1111/j.1468-0009.2012.00662.x 10.1371/journal.pone.0133279 10.1177/1756285616634247 10.1177/1756286419892077 10.1016/j.msard.2020.102144 10.1177/1609406917733847 10.1080/2159676X.2019.1704846
BMC Health Services Research; Sippel A, Riemann-Lorenz K et. al.

Oct 24th, 2021 - Besides coping with a disease with many uncertainties, people with relapsing-remitting multiple sclerosis face complex decisions concerning disease-modifying therapies (DMTs). In an interview study, we aimed to assess patients' experiences with DMTs. Problem-centred interviews were conducted with 50 people with relapsing-remitting multiple sclerosis in Germany using maximum variation sampling a...

Molecular response to PARP1 inhibition in ovarian cancer cells as determined by mass sp...
https://doi.org/10.1186/s13048-021-00886-x
Journal of Ovarian Research; Franz A, Coscia F et. al.

Oct 24th, 2021 - Poly (ADP)-ribose polymerase (PARP) inhibitors have entered routine clinical practice for the treatment of high-grade serous ovarian cancer (HGSOC), yet the molecular mechanisms underlying treatment response to PARP1 inhibition (PARP1i) are not fully understood. Here, we used unbiased mass spectrometry based proteomics with data-driven protein network analysis to systematically characterize how...

Altered functional brain dynamics in chromosome 22q11.2 deletion syndrome during facial...
https://doi.org/10.1038/s41380-021-01302-y 10.1038/nrdp.2015.71 10.1176/appi.ajp.2013.13070864 10.1016/j.biopsych.2013.07.019 10.1097/WCO.0b013e328352dd58 10.1016/J.NEUROIMAGE.2018.09.001 10.1186/s11689-016-9135-z 10.1016/j.bpsc.2019.04.004 10.1016/j.schres.2012.05.021 10.1038/mp.2013.189 10.1016/j.neuropsychologia.2006.06.003 10.3389/fpsyg.2017.01867 10.1016/j.bandc.2011.04.005 10.1016/j.brainres.2009.06.096 10.1016/J.NEUROIMAGE.2009.02.011 10.1097/01.chi.0000205704.33077.4a 10.1186/s11689-015-9120-y 10.1016/j.biopsych.2007.02.022 10.1186/1866-1955-7-1 10.1093/schbul/sbx004 10.1002/hbm.22820 10.1093/schbul/sbz032 10.1016/j.cortex.2019.12.014 10.3102/10769986027002105 10.1007/BF02294589 10.1001/jamapsychiatry.2014.3169 10.1016/j.brainres.2007.10.105 10.1016/j.neuroimage.2013.07.064 10.1016/j.neuroimage.2015.03.056 10.1176/appi.ajp.159.12.1992 10.1038/s41592-018-0235-4 10.1038/s41596-018-0065-y 10.1176/appi.ajp.162.7.1256 10.1006/nimg.2000.0710 10.1523/JNEUROSCI.4764-14.2015 10.1002/hbm.20803 10.1001/archpsyc.64.12.1356 10.1016/j.neuroimage.2017.02.036 10.1073/pnas.98.2.676 10.1146/annurev-neuro-071013-014030 10.1016/j.neuroimage.2018.05.070 10.1038/nrn3857 10.1186/1471-2202-9-102 10.1016/j.schres.2006.04.007 10.1176/appi.ajp.162.6.1090 10.1093/cercor/bht304 10.1038/nrn1825 10.1016/j.celrep.2017.05.002 10.1016/j.neuroimage.2013.08.048 10.1016/j.tics.2020.01.008 10.1038/s42003-020-0961-x 10.1016/J.NEUROIMAGE.2013.12.039 10.1038/ncomms9414 10.1038/s42254-019-0040-8 10.1103/RevModPhys.90.031003 10.1002/hbm.25358 10.1038/s41593-020-0658-y 10.1017/S0020818313000209 10.1038/s41550-017-0141 10.1093/joc/jqy003 10.1017/pan.2018.12 10.1890/00-0634 10.1037/neu0000248
Molecular Psychiatry; Cornblath EJ, Mahadevan A et. al.

Oct 24th, 2021 - Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a multisystem disorder associated with multiple congenital anomalies, variable medical features, and neurodevelopmental differences resulting in diverse psychiatric phenotypes, including marked deficits in facial memory and social cognition. Neuroimaging in individuals with 22q11.2DS has revealed differences relative to matched controls in BOL...

Application of comprehensive bioinformatics approaches to reconnoiter crucial genes and...
https://doi.org/10.1007/s12032-021-01576-w 10.1002/hep.31288 10.1016/j.jceh.2014.05.013 10.1097/MOG.0000000000000626 10.1155/2017/5728946 10.1097/MD.0000000000006938 10.1016/j.biopha.2018.11.127 10.1002/hep.21622 10.1016/j.cyto.2015.11.011 10.1016/j.jhep.2012.01.029 10.3390/ijms161023683 10.5001/omj.2020.21 10.1016/j.cyto.2019.02.006 10.1038/sj.bjc.6603061 10.1038/s41467-019-12393-1 10.1186/1476-9255-9-39 10.2147/CMAR.S248539 10.1038/s41417-019-0109-7 10.1158/1078-0432.CCR-14-1936 10.3892/ol.2020.11844 10.1002/jcp.26816 10.1016/j.ecl.2012.04.014 10.4061/2011/523420 10.3390/cancers7010179 10.1038/sj.onc.1210799 10.1002/1098-2264(2000)9999:9999<::AID-GCC1044>3.0.CO;2-N 10.21873/anticanres.13341 10.1186/s12935-019-0956-1 10.1186/s12935-020-01191-1 10.3390/cancers13092232 10.3892/ijmm.2017.3079 10.1016/j.celrep.2017.11.033 10.2174/1568009614666140804154511 10.18632/oncotarget.13760 10.1111/bph.12045 10.1016/j.leukres.2014.06.005
Medical Oncology (Northwood, London, England); Nair G, Hema Sree GNS et. al.

Oct 24th, 2021 - Hepatocellular carcinoma (HCC) is the fifth most common neoplasm in the world. Chronic inflammation of liver and associated wound healing processes collectively contribute to the development of cirrhosis which further progresses to dysplastic nodule and then to HCC. Etiological mediators and ongoing manipulations at cellular level in HCC are well established; however, key protein interactions a...

Glioma: molecular signature and crossroads with tumor microenvironment.
https://doi.org/10.1007/s10555-021-09997-9 10.1007/s00109-009-0440-9 10.1101/gad.261982.115.tumors 10.1016/j.trecan.2020.01.009 10.1172/JCI89587 10.1007/978-3-030-49270-0_11 10.1016/j.cmet.2019.06.001 10.1212/WNL.0000000000002770 10.1016/j.tranon.2019.10.002 10.3390/cancers11030292 10.1093/neuonc/now005 10.1111/cas.13826 10.1038/s41392-021-00499-2 10.1007/s00401-016-1545-1 10.3389/fimmu.2019.03137 10.1042/BST20180444 10.3390/IJMS160511055 10.1146/annurev-physiol-021119-034627 10.3892/ijmm.2016.2639 10.1158/0008-5472.CAN-17-3551 10.1038/sigtrans.2017.40 10.1093/neuonc/nox054 10.1016/j.neo.2018.11.007 10.1038/nm1517 10.1016/j.jocn.2010.04.021 10.1016/j.ccell.2019.05.003 10.1016/S0945-053X(98)90012-9 10.1002/stem.415 10.3389/FCELL.2021.600506 10.1093/carcin/bgu134 10.1158/0008-5472.CAN-16-2832 10.1097/NEN.0b013e31823fe8f1 10.1158/0008-5472.CAN-11-1031 10.1016/j.trecan.2015.10.009 10.1371/journal.pone.0003655 10.1083/jcb.84.3.495 10.1124/pr.117.014944 10.1007/s00726-011-0867-5 10.3390/ijms20071796 10.1038/NCB1725 10.3390/ijms18112342 10.1186/S12964-020-00589-8 10.1038/onc.2011.563 10.1158/1078-0432.CCR-18-2402 10.3390/ijms20215347 10.1007/s11910-013-0345-4 10.1016/j.jneuroim.2016.05.019 10.1038/s41598-019-47021-x 10.1007/s00401-018-1842-y 10.1038/s41580-019-0134-2 10.1002/(SICI)1098-1136(199903)26:1<55::AID-GLIA6>3.0.CO;2-1 10.1007/s00401-009-0550-z 10.1007/s00401-004-0929-9 10.1007/s00401-011-0802-6 10.3390/cancers12010114 10.1186/s12885-019-6177-0 10.1038/ncomms7999 10.1056/NEJMoa043331 10.1016/j.cell.2013.03.020 10.1038/nature05529 10.1038/s41418-018-0126-3 10.3389/fonc.2018.00164 10.1038/oncsis.2014.36 10.1158/0008-5472.CAN-11-3732 10.1126/science.6320372 10.1002/ana.410360505 10.3390/cancers11091220 10.1097/CCO.0b013e32835b639e 10.1159/000495920 10.1007/S00401-003-0810-2 10.1186/s40425-019-0536-x 10.1016/S0165-5728(99)00203-9 10.1038/s41598-020-72488-4 10.3389/FIMMU.2020.585034 10.1215/15228517-2007-035 10.1016/j.ccell.2017.02.009 10.1515/ISS-2019-0001 10.1186/S12885-019-6384-8 10.1016/j.prp.2020.153141 10.1158/ajc.1938.333 10.1158/0008-5472.CAN-06-1010 10.1016/j.ccr.2006.11.020 10.1080/10717544.2017.1386731 10.1038/s41419-019-1387-6 10.1007/s11060-010-0261-2 10.1073/pnas.102660199 10.1006/cyto.2003.2008 10.1038/sj.onc.1202217 10.1038/nrc.2017.77 10.1038/ncomms5196 10.1016/j.cell.2013.02.021 10.1155/2016/9768183 10.1016/j.jns.2020.116837 10.1038/s41388-020-1308-2 10.1158/0008-5472.CAN-13-2650 10.1007/S12035-018-1385-1 10.1074/mcp.RA118.000644 10.1038/NCB1800 10.1593/neo.05583 10.1007/s11864-019-0619-4 10.3389/fimmu.2020.603911 10.1158/1078-0432.CCR-15-0428 10.1158/0008-5472.CAN-14-0296 10.1016/S1470-2045(12)70090-6 10.1001/jamaoncol.2020.1024 10.1158/1078-0432.CCR-16-0506 10.1186/s12967-017-1202-z 10.1093/neuonc/nou348 10.1093/neuonc/not203 10.1007/s00262-016-1890-x 10.1158/1078-0432.CCR-16-2057 10.1158/1078-0432.CCR-15-2163
Cancer Metastasis Reviews; Barthel L, Hadamitzky M et. al.

Oct 24th, 2021 - In patients with glioblastoma, the average survival time with current treatments is short, mainly due to recurrences and resistance to therapy. This insufficient treatment success is, in large parts, due to the tremendous molecular heterogeneity of gliomas, which affects the overall prognosis and response to therapies and plays a vital role in gliomas' grading. In addition, the tumor microenvir...

Neocortical development and epilepsy: insights from focal cortical dysplasia and brain ...
https://doi.org/10.1016/S1474-4422(21)00265-9
The Lancet. Neurology; Blumcke I, Budday S et. al.

Oct 24th, 2021 - During the past decade, there have been considerable advances in understanding of the genetic and morphogenic processes underlying cortical malformations and developmental brain tumours. Focal malformations are caused by somatic (postzygotic) variants in genes related to cell growth (ie, in the mTOR pathway in focal cortical dysplasia type 2), which are acquired in neuronal progenitors during n...

Prolonged sub-lethal exposure to galaxolide (HHCB) and tonalide (AHTN) promotes the met...
https://doi.org/10.1016/j.neuro.2021.10.006
Neurotoxicology Doğanlar O, Doğanlar ZB et. al.

Oct 24th, 2021 - Galaxolide and tonalide are well-known polycyclic musks whose intensive use without limitations in numerous cleaning, hygiene, and personal care products has resulted in widespread direct human exposure via absorption, inhalation, and oral ingestion. Latest data shows that long-term, low-dose exposure to toxic chemicals can induce unpredictable harmful effects in a variety of living systems, ho...

The recruitment mechanisms and potential therapeutic targets of podocytes from parietal...
https://doi.org/10.1186/s12967-021-03101-z 10.12688/f1000research.7255.1 10.1007/s00424-017-2016-9 10.1007/s00424-017-2025-8 10.1159/000481634 10.1016/j.semnephrol.2012.06.007 10.1681/asn.2006010089 10.1159/000313943 10.1681/asn.2008070709 10.1155/2015/318935 10.1152/ajprenal.00438.2014 10.1152/ajprenal.00497.2015 10.1681/asn.2006030275 10.1152/ajprenal.00428.2009 10.1152/ajprenal.00516.2011 10.1152/ajprenal.00020.2013 10.1159/000342808 10.1681/asn.2009010122 10.1681/asn.2009020132 10.1681/asn.2010090970 10.1016/j.ajpath.2014.08.007 10.1097/MNH.0b013e32835fefd4 10.1038/ki.2015.152 10.4132/jptm.2016.09.21 10.1152/ajprenal.00266.2019 10.1681/asn.2008070795 10.1681/asn.2013050452 10.18632/aging.101176 10.1681/asn.2014020190 10.1681/asn.2019070696 10.1152/ajprenal.00196.2016 10.1007/s10157-015-1222-z 10.2215/cjn.10571011 10.1681/asn.2012050445 10.1038/ki.2015.273 10.3906/sag-1704-102 10.1016/j.ajpath.2013.04.017 10.1016/j.ajpath.2011.04.003 10.1016/j.ajpath.2011.03.004 10.1038/ki.2013.115 10.18632/aging.103788 10.1152/ajprenal.00144.2015 10.1152/physrev.00005.2017 10.1242/jcs.127308 10.3390/biom9110692 10.1038/ki.2013.48 10.1038/ki.2013.66 10.1007/s00467-007-0504-4 10.1002/dvdy.1164 10.1016/j.semnephrol.2012.06.006 10.1074/jbc.M111.223164 10.1152/ajprenal.00056.2013 10.1093/ajcp/88.3.278 10.1016/j.jpedsurg.2018.09.005 10.1007/978-1-4939-4023-3_2 10.1016/0092-8674(93)90515-r 10.3760/cma.j.issn.0578-1310.2018.10.010 10.1242/dev.153163 10.1016/j.semnephrol.2014.06.008 10.1371/journal.pone.0034907 10.1073/pnas.0901591106 10.1038/nm.3142 10.1016/j.ajpath.2018.07.025 10.1182/blood-2003-07-2459 10.1242/dev.119735 10.1007/s00418-017-1550-z 10.1074/jbc.M109.094334 10.1681/asn.2013101067 10.1016/j.kint.2017.11.014 10.1016/j.kint.2018.08.013 10.1016/j.ajpath.2017.07.004 10.1038/ki.2011.463 10.1002/stem.492 10.1152/ajprenal.00415.2009 10.1016/j.kint.2018.09.011 10.1093/ndt/gfs030 10.1038/nm.2491 10.1038/labinvest.2011.43
Journal of Translational Medicine; Ni L, Yuan C et. al.

Oct 23rd, 2021 - Podocytes are differentiated postmitotic cells which cannot be replaced after podocyte injury. The mechanism of podocyte repopulation after injury has aroused wide concern. Parietal epithelial cells (PECs) are heterogeneous and only a specific subpopulation of PECs has the capacity to replace podocytes. Major progress has been achieved in recent years regarding the role and function of a subset...

Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived n...
https://doi.org/10.1038/s41467-021-26297-6 10.1016/S1470-2045(09)70025-7 10.1016/j.cell.2013.09.034 10.1038/ng.2764 10.1016/j.ccr.2012.08.024 10.1016/j.ccell.2017.06.003 10.1101/gad.324301.119 10.1038/nrclinonc.2017.166 10.1038/nature03128 10.1038/s41467-020-17186-5 10.1016/j.ccr.2008.12.006 10.1038/75596 10.1038/s41586-018-0389-3 10.1038/nature23666 10.1016/j.cell.2019.06.024 10.1084/jem.20190196 10.1186/s13059-018-1420-6 10.1056/NEJMoa043331 10.1038/nature26000 10.1016/j.ccr.2009.12.020 10.1016/j.celrep.2013.04.021 10.1016/j.stem.2009.03.014 10.15252/embj.2019103790 10.1038/nature24052 10.1016/j.stem.2009.06.008 10.1038/nature09798 10.1073/pnas.1202352109 10.1038/nbt1010-1045 10.1038/s41467-018-05067-x 10.1101/gr.224436.117 10.1016/j.cell.2015.06.016 10.1038/s41467-018-03190-3 10.1371/journal.pone.0170735 10.1016/j.cell.2013.09.028 10.1038/ncomms15795 10.1038/onc.2015.119 10.1093/neuonc/nov321 10.1016/j.immuni.2017.10.021 10.1038/s41388-020-1161-3 10.1186/s13059-017-1349-1 10.1007/s11060-015-1849-3 10.1093/nar/gkx1143 10.1016/j.stem.2016.11.003 10.1586/17476348.2015.992783 10.1016/j.cell.2016.08.056 10.1016/j.celrep.2019.02.063 10.1158/2159-8290.CD-20-0057 10.1369/jhc.2010.955773 10.1124/pr.111.005538 10.1093/neuonc/nou305 10.1007/s11523-018-0590-1 10.1038/ng.2682 10.1016/j.stem.2018.03.011 10.1371/journal.pone.0009777 10.1038/nm0418-526a 10.1038/s41593-018-0333-8 10.3389/fncel.2019.00026 10.1016/j.scr.2017.10.013 10.1215/15228517-2006-006 10.1007/s11060-006-9314-y 10.1158/0008-5472.CAN-05-3773 10.1158/1078-0432.CCR-14-0514 10.1158/1078-0432.CCR-17-1846 10.1146/annurev-bioeng-071516-044610 10.1096/fj.201802610RR 10.1089/omi.2011.0102 10.1007/s11060-019-03125-y 10.1016/j.celrep.2020.107897 10.1038/nprot.2015.075 10.1371/journal.pone.0138705 10.1093/glycob/cwn028 10.1074/jbc.M111.287474 10.1016/j.ejca.2013.09.004 10.1093/bioinformatics/btp616 10.12688/f1000research.13196.1 10.1093/bioinformatics/btv145 10.1038/nmeth.4197 10.1093/bioinformatics/bts635 10.1186/gb-2014-15-2-r30 10.1186/gb-2012-13-6-r44 10.1186/1471-2105-15-141 10.1101/gr.1239303
Nature Communications; Vinel C, Rosser G et. al.

Oct 23rd, 2021 - Epigenetic mechanisms which play an essential role in normal developmental processes, such as self-renewal and fate specification of neural stem cells (NSC) are also responsible for some of the changes in the glioblastoma (GBM) genome. Here we develop a strategy to compare the epigenetic and transcriptional make-up of primary GBM cells (GIC) with patient-matched expanded potential stem cell (EP...

Pre- and probiotics in the management of children with autism and gut issues: a review ...
https://doi.org/10.1038/s41430-021-01027-9 10.1542/peds.2013-3995 10.1016/j.psychres.2017.10.040 10.1542/peds.2012-2191 10.1007/s10803-010-1095-7 10.3389/fmicb.2018.03146 10.1093/nutrit/nuw048 10.3390/ijms21114159 10.1038/s41575-020-0344-2 10.1371/journal.pone.0210064 10.1016/j.phrs.2020.104784 10.1093/femsec/fiw233 10.1186/s40168-018-0523-3 10.3164/jcbn.18-105 10.1089/cap.2018.0156 10.1016/j.nut.2011.08.002 10.1038/pr.2015.51 10.1080/1028415X.2017.1347746 10.1016/j.physbeh.2014.10.033 10.3389/fpsyt.2020.550593 10.1177/088307380001500701 10.1111/nmo.13440 10.1186/s12986-016-0070-5 10.1371/journal.pone.0034938 10.3748/wjg.v19.i2.235 10.1016/j.jped.2015.01.010 10.1542/peds.2010-0467 10.1097/MPG.0b013e3181ca4d95 10.1111/j.1365-2982.2011.01796.x 10.1136/gutjnl-2016-312361 10.1016/j.neubiorev.2019.03.023 10.1080/19490976.2016.1278104 10.1111/apa.14590 10.1186/s13073-016-0300-5 10.1016/j.bbi.2018.03.025 10.1016/j.cell.2013.11.024 10.3389/fcimb.2021.630052 10.1002/aur.2560 10.1186/s40168-016-0225-7 10.1038/s41598-019-42183-0 10.14309/ajg.0000000000001075
European Journal of Clinical Nutrition; Mitchell LK, Davies PSW

Oct 23rd, 2021 - Manipulation of the gut microbiome offers a promising treatment option for children with autism spectrum disorder (ASD) for whom functional gastrointestinal disorders (FGIDs) are a common comorbidity. Both ASD and FGIDs have been linked to dysfunction of the microbiome-gut-brain (MGB) axis. Dysfunction of this bidirectional network has the ability to impact multiple host processes including gas...

Markers of Immune Activation and Inflammation in Individuals With Postacute Sequelae of...
https://doi.org/10.1093/infdis/jiab490
The Journal of Infectious Diseases; Peluso MJ, Lu S et. al.

Oct 23rd, 2021 - The biological processes associated with postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) are unknown. We measured soluble markers of inflammation in a SARS-CoV-2 recovery cohort at early (<90 days) and late (>90 days) timepoints. We defined PASC as the presence of 1 or more coronavirus disease 2019 (COVID-19)-attributed symptoms beyond 90 days...

Proteomics of ZIKV infected amniotic fluids of microcephalic fetuses reveals extracellu...
https://doi.org/10.1002/prca.202100041
Proteomics. Clinical Applications; Sosa-Acosta P, Melani RD et. al.

Oct 23rd, 2021 - During pregnancy, the vertical transmission of the Zika virus (ZIKV) can cause some disorders in the fetus, called Congenital Zika Syndrome (CZS). Several efforts have been made to understand the molecular mechanism of the CZS. However, the study of CZS pathogenesis through infected human samples is scarce. Therefore, the main goal of this study is to identify and understand the biological proc...

Natural History of Noncirrhotic Portal Hypertension
https://clinicaltrials.gov/ct2/show/NCT02417740

Oct 22nd, 2021 - Noncirrhotic Portal Hypertension (NCPH) includes a spectrum of chronic liver diseases characterized by increased pressure within the portal circulation in the absence of cirrhosis. The complications from NCPH are similar to that of cirrhosis induced portal hypertension which includes the development of gastrointestinal varices, portal hypertensive gastropathy, splenomegaly, sepsis and ascites. ...

Biochemical and Phenotypical Aspects of Smith-Lemli-Opitz Syndrome and Related Disorders of Cholesterol Metabolism
https://clinicaltrials.gov/ct2/show/NCT05047354

Oct 22nd, 2021 - Smith-Lemli-Opitz Syndrome (SLOS) is an autosomal recessive inborn error of metabolism secondary to cholesterol synthesis abnormalities that usually manifests with a combination of typical dysmorphology and intellectual disability. It is caused by homozygosity for pathological variants of DHCR7, whose protein product catalyzes the conversion of 7-dehydrocholesterol (7-DHC) to cholesterol. This ...

Second-line Treatment of Primary Autoimmune Hemolytic Anemia
https://clinicaltrials.gov/ct2/show/NCT05057468

Oct 22nd, 2021 - Auto-immune hemolytic anemia (AIHA) is a heterogeneous syndrome in adults. This disease is associated with significant morbidity-mortality. First-line treatment with prolonged corticosteroid is well identified but there is not enough data about cyclosporine treatment in case of resistance or dependence on steroids. the cyclosporine showed efficacy in many immune cytopenic diseases in the light ...

Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders
https://clinicaltrials.gov/ct2/show/NCT05064319

Oct 22nd, 2021 - This research study evaluates the effects of an FDA-approved medication Gabapentin in individuals with Bipolar Disorder who smoke marijuana. Participants in the study will will be assigned to take either Gabapentin or a matched placebo. Study medication will be taken for 17 days. There will be 5 study visits, with 2 MRI brain imaging scans completed. Questionnaires and clinical interview measur...

PET Imaging of Cyclooxygenase-2 in Multiple Sclerosis
https://clinicaltrials.gov/ct2/show/NCT05062083

Oct 22nd, 2021 - Study Description: This study will examine whether cyclooxygenase 2 (COX-2) is elevated in the brain of individuals with Multiple Sclerosis (MS) Objectives: To determine whether COX-2 is detectable in the brains of individuals with MS Endpoints: Primary endpoint: Calculation of COX-2 density from [11C]MC1 PET scans, using baseline scans and scans after blockade with celecoxib Secondary endpoint...

A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
https://clinicaltrials.gov/ct2/show/NCT05027945

Oct 22nd, 2021 - Background: In 2019, investigators at the National Institutes of Health defined a new disease syndrome named VEXAS: Vacuoles in bone marrow cells, E1 enzyme mutations, X-linked, Autoinflammatory, Somatic syndrome. This syndrome is characterized by inflammatory and hematologic features and is frequently accompanied by marrow dysplasia, progressive bone marrow failure, and in some cases, the deve...

Non Invasive Neurostimulation Technology for the Treatment of Type I Complex Regional Pain Syndrome (CRPS I)
https://clinicaltrials.gov/ct2/show/NCT05052736

Oct 22nd, 2021 - The design of this study is a randomised, triple blind clinical trial with placebo control. The size of the sample will be 42 participants who come to referral hospitals. They will be randomized in two groups: control or experimental. The variables of the study will be collected at three time points: before the intervention, during the intervention and at the end of the intervention. The variab...