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About 402,778 results

Motor Functioning and Intelligence Quotient in Paediatric Survivors of a Fossa Posterio...
https://doi.org/10.3390/ijerph19127083
International Journal of Environmental Research and Publi... Decock M, De Wilde R et. al.

Jun 25th, 2022 - Short- and long-term consequences after treatment for childhood fossa posterior tumors are extensively reported in the literature; however, papers highlighting physical function throughout rehabilitation and its correlation with Intelligence Quotient (IQ) are sparse. This study aims to describe the physical functioning and IQ of these survivors, their progression during rehabilitation, and the ...

Giant cystic parathyroid adenoma: two case reports and a literature review.
https://doi.org/10.1177/03000605221106419
The Journal of International Medical Research; Weng J, Zhou W et. al.

Jun 24th, 2022 - An uncommon cause of primary hyperparathyroidism is a cystic parathyroid adenoma. This paper describes two patients with hypercalcemia and right knee disease. Their serum calcium concentration was high, phosphorus concentration was low, and parathyroid hormone (PTH) concentration was high. Ultrasound and computed tomography scans of the neck indicated a cystic mass near the thyroid. Parathyroid...

Living-Donor Liver Transplantation for Hepatocellular Carcinoma: Impact of the MELD Sco...
https://doi.org/10.3390/curroncol29060310
Current Oncology (Toronto, Ont.); Hung HC, Lee JC et. al.

Jun 24th, 2022 - Patients with hepatocellular carcinoma (HCC) tend to be referred for liver transplantation (LT) at an early stage of cirrhosis, with lower pre-LT Model of End-Stage Liver Disease (MELD) scores. We investigated the impact of high MELD scores on post-LT outcomes in patients with HCC and validated the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR). This retrospective single-ce...

Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.
https://doi.org/10.3390/curroncol29060324
Current Oncology (Toronto, Ont.); Joo MW, Lee YS et. al.

Jun 24th, 2022 - Giant cell tumor of bone (GCTB) undergoes a sarcomatous transformation. Secondary malignancy in giant cell tumor (MGCT) is associated with radiotherapy and has a dismal prognosis. We reviewed medical records to investigate the clinicopathological characteristics and prognosis of MGCT patients. The enrollment criterion was high-grade spindle-cell sarcoma, which developed at the site of prior GCT...

Does Systemic Chemotherapy Influence Skeletal Growth of Young Osteosarcoma Patients as ...
https://doi.org/10.3390/curroncol29060325
Current Oncology (Toronto, Ont.); Hoshi M, Oebisu N et. al.

Jun 24th, 2022 - The aim of this study was to investigate the influence of systemic chemotherapy on the skeletal growth of young osteosarcoma patients as a treatment-related late adverse effect. We reviewed the height data of 20 osteosarcoma patients (13 males and 7 females) aged ≤18 years. The average (±SD) age at diagnosis was 14.5 (±3.3) years. The average follow-up interval was 89.6 months. After wide resec...

Refractory Splenic Marginal Zone Lymphoma Responsive to Combination Venetoclax and Bort...
https://doi.org/10.3390/curroncol29060328
Current Oncology (Toronto, Ont.); Roche KC, DeRosa PA et. al.

Jun 24th, 2022 - Standard treatment regimens for the management of patients with refractory splenic marginal zone lymphoma (SMZL) are currently unavailable. Here, we report a case of SMZL, which, after failing multiple therapeutics, demonstrated an impressive clinical response to combined Venetoclax and Velcade (V2), a treatment combination currently being investigated in the setting of refractory multiple myel...

Sunitinib-Induced Elevation of Mean Corpuscular Volume (MCV)-Exploring Its Possible Cli...
https://doi.org/10.3390/curroncol29060330
Current Oncology (Toronto, Ont.); Rihacek M, Selingerova I et. al.

Jun 24th, 2022 - Sunitinib is a broad-spectrum multitargeted tyrosine kinase inhibitor mainly used as second-line therapy for non-resectable gastrointestinal stromal or first-line treatment option of metastatic renal cell carcinoma (mRCC), and as an "off-label" option in pediatric oncology. It has been previously reported that sunitinib elevates the mean corpuscular volume of erythrocytes (MCV) in treated subje...

Extra-Pleural Pneumonectomy (EPP) in Children and Adults with Locally Advanced Sarcoma:...
https://doi.org/10.3390/curroncol29060340
Current Oncology (Toronto, Ont.); Rodrigues C, Peretz Soroka H et. al.

Jun 24th, 2022 - Sarcoma can present as locally advanced disease involving pleura for which extra-pleural pneumonectomy (EPP) may be the only surgical option to ensure adequate local control. Data were collected on patients who underwent EPP between January 2009 and August 2021 at Princess Margret Hospital and SickKids (Toronto) using the CanSaRCC (Canadian Sarcoma Research and Clinical Collaboration). Ten pati...

A 3-miRNA Signature Enables Risk Stratification in Glioblastoma Multiforme Patients wit...
https://doi.org/10.3390/curroncol29060345
Current Oncology (Toronto, Ont.); Bafiti V, Ouzounis S et. al.

Jun 24th, 2022 - Malignant gliomas constitute a complex disease phenotype that demands optimum decision-making as they are highly heterogeneous. Such inter-individual variability also renders optimum patient stratification extremely difficult. microRNA (hsa-miR-20a, hsa-miR-21, hsa-miR-21) expression levels were determined by RT-qPCR, upon FFPE tissue sample collection of glioblastoma multiforme patients (n = 3...

Conservative Management of Low Back Pain Related to an Unresectable Aggressive Sacral H...
https://doi.org/10.12659/AJCR.936984
The American Journal of Case Reports; Chu EC, Trager RJ et. al.

Jun 24th, 2022 - BACKGROUND Aggressive sacral hemangiomas are extremely rare benign tumors that can extend into the spinal canal, causing neurologic symptoms. Research on these tumors is limited given their rarity, and they have no agreed-upon treatment strategy. We report the first case of an aggressive sacral hemangioma responding well to conservative care, including manual therapies. CASE REPORT A 56-year-ol...

Potentials of autophagy enhancing natural products in the treatment of Parkinson disease.
https://doi.org/10.1515/dmpt-2021-0128
Drug Metabolism and Personalized Therapy; Olubodun-Obadun TG, Ishola IO et. al.

Jun 24th, 2022 - Parkinson disease (PD) is a progressive neurodegenerative movement disorder characterized by motor and non-motor symptoms due to loss of striatal dopaminergic neurons and disruption of degradation signaling leading to the formation of Lewy bodies (aggregation of α-synuclein). Presently, there are no disease modifying therapy for PD despite improvement in the understanding of the disease pathoge...

Intestinal Barrier Dysfunction in Fatty Liver Disease: Roles of Microbiota, Mucosal Imm...
https://doi.org/10.1055/s-0042-1748037
Seminars in Liver Disease; Gupta B, Rai R et. al.

Jun 24th, 2022 - Nonalcoholic fatty liver disease (NAFLD) describes a spectrum of progressive liver diseases ranging from simple steatosis to steatohepatitis and fibrosis. Globally, NAFLD is the leading cause of morbidity and mortality associated with chronic liver disease, and NAFLD patients are at a higher risk of developing cirrhosis and hepatocellular carcinoma. While there is a consensus that inflammation ...

Involvement of Epigenomic Factors in Bile Duct Cancer.
https://doi.org/10.1055/s-0042-1748188
Seminars in Liver Disease; Rogalska-Taranta M, Andersen JB

Jun 24th, 2022 - Cholangiocarcinoma (CCA) is the second most common type of primary liver cancer. Due to its often-silent manifestation, sporadic nature, and typically late clinical presentation, it remains difficult to diagnose and lacks effective nonsurgical therapeutic options. Extensive research aiming in understanding the mechanisms underlying this disease have provided strong evidence for the significance...

New insights from non-invasive imaging: from prospection of skin photodamages to traini...
https://doi.org/10.1111/jdv.18197
Journal of the European Academy of Dermatology and Venere... Pellacani G, Argenziano G

Jun 24th, 2022 - The incidence of non-melanoma skin cancer is on the rise and melanoma is among the most common cancers in the United States. Establishing an early diagnosis is essential for improving the prognosis of patients with skin cancer. High-resolution non-invasive imaging techniques may represent key tools for helping to identify and monitor early signs of skin cancer in seemingly healthy skin. Cumulat...

Assessing prognosis in IgA nephropathy.
https://doi.org/10.1016/j.kint.2022.04.018
Kidney International; Floege J, Wied S et. al.

Jun 24th, 2022 - Assessing the prognosis is essential in chronic diseases, such as IgA nephropathy. The 2021 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend the "International IgAN Prediction Tool" (available at www.qxmd.com) for this. The key limitation was that the tool was only validated at the time of the kidney biopsy. An improved algorithm is now described, which allows assessing th...

Identification of key genes and pathways related to cancer-associated fibroblasts in ch...
https://doi.org/10.1186/s13048-022-01003-2 10.3322/caac.21660 10.2353/ajpath.2010.100105 10.1038/nrdp.2016.61 10.1093/annonc/mdw088 10.1016/S1470-2045(21)00216-3 10.1016/j.cell.2020.03.013 10.3892/or.2018.6311 10.1016/j.cell.2018.01.028 10.1172/JCI95200 10.1016/j.bbrc.2016.01.131 10.3892/ijo.2016.3442 10.1155/2021/8883800 10.1038/ng.2764 10.1007/s10863-016-9669-5 10.1002/cam4.2171 10.1016/j.bbrc.2019.02.089 10.1186/s12885-019-5824-9 10.7150/jca.29889 10.1016/j.bbcan.2020.188361 10.1016/j.bbcan.2020.188416 10.1007/s10637-017-0547-8 10.1111/cas.14578 10.7150/thno.25541 10.1002/jcp.27926 10.2217/fon-2020-0095 10.12659/MSM.909290 10.3892/ijmm.2020.4716 10.1016/j.jbi.2019.103313 10.1038/nature21356 10.7150/thno.37621 10.1016/j.ebiom.2019.05.003 10.1038/s41388-021-01957-5 10.1016/j.cell.2013.08.015 10.29252/ibj.24.6.365 10.1007/s00109-016-1475-3
Journal of Ovarian Research; Han L, Guo X et. al.

Jun 24th, 2022 - Studies have revealed the implications of cancer-associated fibroblasts (CAFs) in tumor progression, metastasis, and treatment resistance. Here, in silico analyses were performed to reveal the key genes and pathways by which CAFs affected chemoresistance in ovarian cancer. Candidate genes were obtained from the intersected differentially expressed genes in ovarian cancer, ovarian cancer chemore...

Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in...
https://doi.org/10.1186/s13073-022-01071-5 10.1038/s41575-019-0186-y 10.1002/hep.28524 10.1038/s41575-020-00381-6 10.1002/hep.31014 10.1053/j.gastro.2018.08.024 10.1038/ng.3252 10.1038/s41575-019-0165-3 10.1016/j.jhep.2020.11.052 10.1155/2014/637027 10.1038/s41580-018-0029-7 10.1126/science.1164097 10.1186/s40170-015-0135-3 10.1016/j.celrep.2016.10.012 10.1016/j.cmet.2016.12.017 10.1038/nature14221 10.1093/bfgp/elx018 10.7759/cureus.11725 10.4103/1008-682X.163190 10.1038/srep18474 10.1038/nmeth.1226 10.1186/gb-2010-11-10-r106 10.1038/s41586-021-03974-6 10.21105/joss.03167 10.1038/s41586-020-1943-3 10.1016/j.cell.2015.05.019 10.1002/bies.202000083 10.1073/pnas.0610772104 10.1186/s13059-019-1661-z 10.1007/978-1-4939-9224-9_14 10.1242/jcs.058271 10.1007/s00204-019-02511-9 10.3390/ijms18091979 10.1371/journal.pone.0166956 10.1016/j.jhep.2012.10.031 10.1038/s41586-019-1670-9 10.1074/jbc.M117.781401 10.18632/oncotarget.17462 10.1016/j.bbagrm.2021.194691 10.5114/ceh.2020.102153 10.3322/caac.21262 10.15252/embj.2020106048 10.3389/fimmu.2020.589929 10.1172/JCI90253 10.1016/j.cmet.2019.05.013 10.1006/excr.1997.3893 10.1002/hep.31288 10.21037/tgh-20-125 10.1007/s12325-019-00898-6 10.1126/science.aaz8455 10.1038/s41598-018-35653-4 10.1038/s41598-020-64293-w 10.1053/j.gastro.2018.07.027 10.1016/j.jhep.2020.04.037 10.1080/13543784.2020.1668374 10.21037/atm-20-4354
Genome Medicine; Assante G, Chandrasekaran S et. al.

Jun 24th, 2022 - The incidence of non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing worldwide, but the steps in precancerous hepatocytes which lead to HCC driver mutations are not well understood. Here we provide evidence that metabolically driven histone hyperacetylation in steatotic hepatocytes can increase DNA damage to initiate carcinogenesis. Global epigeneti...

CDC20 regulates sensitivity to chemotherapy and radiation in glioblastoma stem cells.
https://doi.org/10.1371/journal.pone.0270251
PloS One; Mao DD, Cleary RT et. al.

Jun 24th, 2022 - Glioblastoma stem cells (GSCs) are an important subpopulation in glioblastoma, implicated in tumor growth, tumor recurrence, and radiation resistance. Understanding the cellular mechanisms for chemo- and radiation resistance could lead to the development of new therapeutic strategies. Here, we demonstrate that CDC20 promotes resistance to chemotherapy and radiation therapy. CDC20 knockdown does...

Biomarker Development Using Liquid Biopsy in Hepatocellular Carcinoma.
https://doi.org/10.1055/s-0042-1748924
Seminars in Liver Disease; Grinspan LT, Villanueva A

Jun 24th, 2022 - Liver cancer incidence rate continues to increase and currently ranks third in the total number of annual deaths, behind only lung and colorectal cancer. Most patients with hepatocellular carcinoma (HCC) are diagnosed at advanced stages, and they live for less than 2 years after diagnosis on average. This contrasts with those diagnosed at an early stage, who can be cured with surgery. However, ...

Characteristics and interplay of esophageal microbiota in esophageal squamous cell carc...
https://doi.org/10.1186/s12885-022-09771-2 10.3322/caac.21660 10.1097/CM9.0000000000001474 10.1038/ajg.2017.155 10.1016/j.cell.2018.07.038 10.1053/j.gastro.2009.04.046 10.1186/1471-2334-13-130 10.1002/cncr.32403 10.3389/fcell.2021.641270 10.1158/1055-9965.EPI-13-0855 10.1186/s12866-021-02137-x 10.1099/jmm.0.000754 10.1053/j.gastro.2019.11.305 10.1038/s41591-018-0164-x 10.1371/journal.pone.0090731 10.1146/annurev.ecolsys.38.091206.095740 10.1038/s41587-019-0209-9 10.1038/s41587-020-0548-6 10.1371/journal.pcbi.1002687 10.1093/bioinformatics/btq675 10.1186/1752-0509-8-S4-S11 10.1053/j.gastro.2017.06.066 10.1186/s13059-014-0550-8 10.1038/nature25973 10.1007/s11356-021-14593-z 10.3389/fmicb.2017.01162 10.3389/fcimb.2020.575656 10.1111/odi.12341 10.3389/fmicb.2017.02391 10.1080/19490976.2017.1379637 10.1002/cam4.2419 10.2147/CMAR.S275316 10.3402/jom.v8.31444 10.1016/j.niox.2020.11.002 10.1016/j.ebiom.2018.12.034 10.3389/fmicb.2019.01261 10.1086/518578 10.1016/j.tim.2015.03.009 10.1016/j.ebiom.2019.04.028 10.1046/j.1365-2036.16.s2.20.x 10.1128/AAC.36.10.2147
BMC Cancer; Lin Z, Rao W et. al.

Jun 24th, 2022 - Esophageal microbiota may influence esophageal squamous cell carcinoma (ESCC) pathobiology. Therefore, we investigated the characteristics and interplay of the esophageal microbiota in ESCC. We performed 16S ribosomal RNA sequencing on paired esophageal tumor and tumor-adjacent samples obtained from 120 primarily ESCC patients. Analyses were performed using quantitative insights into microbial ...