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About 419,695 results

Sortilin 1 regulates hepatocellular carcinoma progression by activating the PI3K/AKT si...
https://doi.org/10.1177/09603271221140111
Human & Experimental Toxicology; Ye S, Wang B et. al.

Nov 30th, 2022 - Sortilin 1 (SORT1) has been reported as an oncogene in several human tumors. Nonetheless, the biological functions of SORT1 in hepatocellular carcinoma (HCC) remain poorly understood. Western blotting was employed for the determination of protein expression. Hepatocellular carcinoma cell viability, apoptosis, migration, and invasion were measured via CCK-8, flow cytometry, wound healing, and Tr...

Stearoyl-CoA Desaturase-1 dependent lipid droplets accumulation in cancer-associated fi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682541
International Journal of Biological Sciences; Zhang Y, Gu Z et. al.

Nov 29th, 2022 - Rationale: Cancer-associated fibroblasts (CAFs) are the main components in the tumor microenvironment (TME) and facilitate lung cancer progression. Studies have reported that metabolic reprogramming can regulate the function of CAFs, especially abnormal lipid metabolism. Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids and have a crucial role in lipid metabolism. However...

Choice of intraoperative ultrasound adjuncts for brain tumor surgery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703786
BMC Medical Informatics and Decision Making; Kumar M, Noronha S et. al.

Nov 28th, 2022 - Gliomas are among the most typical brain tumors tackled by neurosurgeons. During navigation for surgery of glioma brain tumors, preoperatively acquired static images may not be accurate due to shifts. Surgeons use intraoperative imaging technologies (2-Dimensional and navigated 3-Dimensional ultrasound) to assess and guide resections. This paper aims to precisely capture the importance of preop...

Multiple system atrophy: α-Synuclein strains at the neuron-oligodendrocyte crossroad.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701437
Molecular Neurodegeneration; Reddy K, Dieriks BV

Nov 27th, 2022 - The aberrant accumulation of α-Synuclein within oligodendrocytes is an enigmatic, pathological feature specific to Multiple system atrophy (MSA). Since the characterization of the disease in 1969, decades of research have focused on unravelling the pathogenic processes that lead to the formation of oligodendroglial cytoplasmic inclusions. The discovery of aggregated α-Synuclein (α-Syn) being th...

Hypermetabolic lymphadenopathy following the administration of COVID-19 vaccine and imm...
https://doi.org/10.1186/s13256-022-03660-9
Journal of Medical Case Reports; Tripathy S, Alvarez N et. al.

Nov 27th, 2022 - Given the current climate of the pandemic, lung cancer patients are especially vulnerable to complications from severe acute respiratory syndrome coronavirus 2 infection. As a high-risk population group, these patients are strongly advised to receive coronavirus disease 2019 vaccination in accordance with Center for Disease Control and Prevention guidelines to minimize morbidity and mortality. ...

Microvascular invasion risk scores affect the estimation of early recurrence after rese...
https://doi.org/10.1186/s12880-022-00940-0
BMC Medical Imaging; Wang S, Zheng W et. al.

Nov 25th, 2022 - Microvascular invasion (MVI) is a histological factor that is closely related to the early recurrence of hepatocellular carcinoma (HCC) after resection. To investigate whether a noninvasive risk score system based on MVI status can be established to estimate early recurrence of HCC after resection. Between January 2018 to March 2021, a total of 108 patients with surgically treated single HCC wa...

Management of Ventral Brainstem Compression in Chiari Malformation Type I.
https://doi.org/10.1016/j.nec.2022.08.002
Neurosurgery Clinics of North America; Dlouhy BJ, Menezes AH

Nov 25th, 2022 - Craniovertebral junction (CVJ) abnormalities are associated with the Chiari malformation type I. These abnormalities may lead to ventral brainstem compression which can be reduced with traction and posterior reduction using instrumentation. In other cases, the irreducible CVJ pathology with persistent ventral brainstem compression requires ventral decompression. In all cases, a posterior extrad...

Biomarkers in Testicular Cancer: Classic Tumor Markers and Beyond.
https://doi.org/10.1016/j.ucl.2022.09.002
The Urologic Clinics of North America; Egan J, Salari K

Nov 25th, 2022 - Biomarkers play a key role in patients with testicular germ cell tumors in a variety of clinical contexts, including initial diagnosis, prognostication, monitoring treatment response, and posttreatment surveillance. Although the classic serum tumor markers for testicular germ cell tumors are essential for clinical management, the low sensitivity (particularly for seminoma and teratoma) and pote...

Current and Future Biomarkers in the Management of Renal Cell Carcinoma.
https://doi.org/10.1016/j.ucl.2022.09.003
The Urologic Clinics of North America; Reese S, Calderon L et. al.

Nov 25th, 2022 - Renal cell carcinoma biomarkers include serum, urine, liquid, and tissue biomarkers. There is currently an ongoing search for predictive biomarkers in the detection, recurrence, and treatment of renal cell carcinoma. Emerging signatures in the transcriptomic and translational biomarker space seem promising, although additional work is needed to validate candidates in a larger and more generaliz...

Challenges of cell therapies for retinal diseases.
https://doi.org/10.1016/bs.irn.2022.09.004
International Review of Neurobiology; Christelle M, Lise M et. al.

Nov 25th, 2022 - Because retinal cells could not regenerate in mammals, retinal degeneration is an irreversible phenomenon caused by various disease conditions including age-related macular degeneration (AMD) and retinitis pigmentosa (RP). During the course of these diseases, photoreceptors (PRs) are susceptible to degenerate due to their malfunctions or to a primary dysfunction of the retinal pigment epitheliu...

STEAP3 can predict the prognosis and shape the tumor microenvironment of clear cell ren...
https://doi.org/10.1186/s12885-022-10313-z
BMC Cancer; Wu J, Bi Q et. al.

Nov 25th, 2022 - Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urinary system characterized by poor prognosis and difficult treatment. It has been reported that iron metabolism dysregulation is a common phenomenon in ccRCC and is closely related to the process of ccRCC. But still now, the exact function and underlying mechanisms of iron metabolism dysregulation in ccRCC have not bee...

Temporal and spatial characteristics of tumor evolution in a mouse model of oral squamo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694863
BMC Cancer; Cao Y, Dong H et. al.

Nov 25th, 2022 - We aimed to elucidate the temporal and spatial characteristics of tumor evolution in an oral squamous cell carcinoma (OSCC) mouse model with higher burden of lymphatic metastasis through high-throughput sequencing. The OSCC model was established in 9 mice. DNA was extracted from the tumors of primary tongue lesions and disseminated tumor cells (DTCs) of submandibular gland lymph nodes and bone ...

Primary cutaneous adenoid cystic carcinoma of the neck presenting as a rapidly growing ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693883
BMJ Case Reports; Hatfield TW, Wilkinson SL et. al.

Nov 25th, 2022 - A woman in her 70s presented to a tertiary otorhinolaryngology outpatient department with a 25-year history of right-sided subcutaneous neck lesion that had steadily grown over the preceding 6 months, now with skin involvement. The patient was asymptomatic except for some mild tenderness. The 3 × 3 cm mass lay fixed to deep tissues adjacent to the sternocleidomastoid muscle, though no associate...

Elevated Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio after First Cy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689285
Current Oncology (Toronto, Ont.); Tseng RH, Lai KM et. al.

Nov 25th, 2022 - Background: Prognostic factors for poor survival have been proposed in esophageal squamous cell carcinoma (SCC) patients receiving concurrent chemoradiotherapy (CCRT). We conducted a retrospective study on hematological profile after first cycle of chemotherapy for esophageal SCC patients receiving CCRT. Methods: From January 2008 to December 2017, a total of 420 patients with esophageal SCC we...

Nomogram Based on Monocyte-to-Lymphocyte Ratio to Predict Survival of Unresectable Esop...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689525
Current Oncology (Toronto, Ont.); Ma X, Ding Y et. al.

Nov 25th, 2022 - Chemoimmunotherapy has become the first-line treatment for unresectable esophageal squamous cell carcinoma (ESCC). Still, reliable biomarkers to identify patients who could benefit from this combined therapy remain uncertain. This study focused on elucidating the predictive significance of the monocyte-to-lymphocyte ratio (MLR) and establishing the prognostic nomogram for unresectable ESCC trea...

Pancreatic Tumorigenesis: Precursors, Genetic Risk Factors and Screening.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689647
Current Oncology (Toronto, Ont.); Badheeb M, Abdelrahim A et. al.

Nov 25th, 2022 - Pancreatic cancer (PC) is a highly malignant and aggressive tumor. Despite medical advancement, the silent nature of PC results in only 20% of all cases considered resectable at the time of diagnosis. It is projected to become the second leading cause in 2030. Most pancreatic cancer cases are diagnosed in the advanced stages. Such cases are typically unresectable and are associated with a 5-yea...

Patterns of Extrathoracic Metastasis in Lung Cancer Patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689009
Current Oncology (Toronto, Ont.); Park HK, Han J et. al.

Nov 25th, 2022 - Metastasis is a major cause of death in lung cancer patients. Therefore, a deeper understanding of the metastatic mechanisms is important for developing better management strategies for lung cancer patients. This study evaluated the patterns of extrathoracic metastases in lung cancer. We retrieved data for 25,103 lung cancer patients from an institutional database and then evaluated the impacts...

Treating Multiple Myeloma in the Context of the Bone Marrow Microenvironment.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689284
Current Oncology (Toronto, Ont.); Ho M, Xiao A et. al.

Nov 25th, 2022 - The treatment landscape of multiple myeloma (MM) has evolved considerably with the FDA-approval of at least 15 drugs over the past two decades. Together with the use of autologous stem cell transplantation, these novel therapies have resulted in significant survival benefit for patients with MM. In particular, our improved understanding of the BM and immune microenvironment has led to the devel...

CSP I-plus modified rEndostatin inhibits hepatocellular carcinoma metastasis via down-r...
https://doi.org/10.1186/s12885-022-10318-8
BMC Cancer; Chen X, Wang Y et. al.

Nov 25th, 2022 - In our previous study, N end of the Circumsporozoite protein (CSP I-plus) modified recombinant human Endostatin (rEndostatin, endostar) (rES-CSP) was constructed, which had antiangiogenic capability and bound to hepatocellular carcinoma in vivo and in vitro. In this study, the inhibition of rES-CSP on hepatocellular carcinoma metastasis was verified in vivo and in vitro, and its possible mechan...

A Modified Regimen of 21-day Nab-Paclitaxel Plus Gemcitabine in Locally Advanced or Met...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703471
Cancer Control : Journal of the Moffitt Cancer Center; Chang C, Meng L et. al.

Nov 25th, 2022 - It is 1 of the standard treatment options for metastasis pancreatic cancer to receive nab-paclitaxel (125 mg/m2) plus gemcitabine (1000 mg/m2) on days 1, 8 and 15 every 28 days. Some patients showed intolerance and inconvenience to this therapeutic regimen. Thus, we conducted this retrospective real-world study to determine the efficacy and tolerability of a modified 21-day nab-paclitaxel plus ...