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About 127,400 results

IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875405
BMC Cancer; Cai W, Ma Y et. al.

Jan 27th, 2023 - Insulin-like growth factor-1 receptor (IGF-1R) promotes cell proliferation and migration and inhibitsapoptosis, all of which can contribute to the development of cancers. This study investigated the effect and mechanism of IGF-1R in mediating the desensitization of hepatocellular carcinoma (HCC) to sorafenib. IGF-1R, highly expressed in the HCC cell lines SK-Hep1 and HepG2, promotes cell prolif...

Somatostatin Receptor PET/MR Imaging of Inflammation in Patients With Large Vessel Vasc...
https://doi.org/10.1016/j.jacc.2022.10.034
Journal of the American College of Cardiology; Ćorović A, Wall C et. al.

Jan 26th, 2023 - Assessing inflammatory disease activity in large vessel vasculitis (LVV) can be challenging by conventional measures. We aimed to investigate somatostatin receptor 2 (SST2) as a novel inflammation-specific molecular imaging target in LVV. In a prospective, observational cohort study, in vivo arterial SST2 expression was assessed by positron emission tomography/magnetic resonance imaging (PET/MR...

Phosphorothioated amino-AS1411 aptamer functionalized stealth nanoliposome accelerates ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875447
Journal of Nanobiotechnology; Dhara M, Al Hoque A et. al.

Jan 25th, 2023 - Hepatocellular carcinoma (HCC) is a leading cause of death globally. Even though the progressive invention of some very potent therapeutics has been seen, the success is limited due to the chemotherapeutic resistance and recurrence in HCC. Advanced targeted treatment options like immunotherapy, molecular therapy or surface-engineered nanotherapeutics could offer the benefits here owing to drug ...

Assessment of motor function and nutritional status in children with spinal muscular at...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869561
BMC Neurology; Yang H, Tao Q et. al.

Jan 24th, 2023 - Spinal muscular atrophy (SMA) is a progressive degenerative neuromuscular disease. Nusinersen, with its quick onset of action, can benefit patients early in the treatment course. However, there are currently no clinical studies regarding the improvement in motor function and nutritional status of patients after loading period treatment with nusinersen. Here, we aimed to determine the efficacy o...

PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activatio...
https://doi.org/10.1084/jem.20220729
The Journal of Experimental Medicine; Ali LR, Garrido-Castro AC et. al.

Jan 24th, 2023 - We performed single-cell RNA-sequencing and T cell receptor clonotype tracking of breast and ovarian cancer patients treated with the CDK4/6 inhibitor ribociclib and PD-1 blockade. We highlight evidence of two orthogonal treatment-associated phenomena: expansion of T cell effector populations and promotion of T cell memory formation. Augmentation of the antitumor memory pool by ribociclib boost...

Mesothelioma-associated fibroblasts enhance proliferation and migration of pleural meso...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869633
Journal of Experimental & Clinical Cancer Research : CR; Ries A, Flehberger D et. al.

Jan 23rd, 2023 - Pleural mesothelioma (PM) is an aggressive malignancy with poor prognosis. Unlike many other cancers, PM is mostly characterized by inactivation of tumor suppressor genes. Its highly malignant nature in absence of tumor driving oncogene mutations indicates an extrinsic supply of stimulating signals by cells of the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are an abundan...

IgA Nephropathy with Macroproteinuria and a GFR of 20-30 ml/min/1.73 m2 May Still Benef...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822756
Journal of the Renin-angiotensin-aldosterone System : JRAAS; Wang Y, Jiang S et. al.

Jan 21st, 2023 - There has been controversy about renin-angiotensin system (RAS) inhibition in IgAN patients with advanced (stage 4) chronic kidney disease (CKD). Therefore, we investigated the effect of RAS blockade in these patients. Renal specimens of 50 IgAN patients who underwent renal biopsy during stage 4 CKD between 2010 and 2020, were stained using immunohistochemistry to detect the expression of RAS r...

Pathogen reduction of monkeypox virus in plasma and whole blood using riboflavin and UV...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857991
PloS One; Ragan IK, Hartson LM et. al.

Jan 21st, 2023 - Monkeypox virus has recently emerged from endemic foci in Africa and, since October 20, 2022, more than 73,000 human infections have been reported by the CDC from over 100 countries that historically have not reported monkeypox cases. The detection of virus in skin lesions, blood, semen, and saliva of infected patients with monkeypox infections raises the potential for disease transmission via ...

Propionate exerts neuroprotective and neuroregenerative effects in the peripheral nervo...
https://doi.org/10.1073/pnas.2216941120
Proceedings of the National Academy of Sciences of the Un... Grüter T, Mohamad N et. al.

Jan 21st, 2023 - In inflammatory neuropathies, oxidative stress results in neuronal and Schwann cell (SC) death promoting early neurodegeneration and clinical disability. Treatment with the short-chain fatty acid propionate showed a significant immunoregulatory and neuroprotective effect in multiple sclerosis patients. Similar effects have been described for patients with chronic inflammatory demyelinating poly...

Network Pharmacology and Experimental Validation to Explore the Molecular Mechanisms of...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843476
Drug Design, Development and Therapy; Di H, Liu H et. al.

Jan 21st, 2023 - Acne is a highly prevalent skin disease, and inflammation plays an important role. Compound Huangbai Liquid (CHL) is a classical traditional Chinese medicine (TCM) with remarkable clinical therapeutic effects on acne. However, a holistic network pharmacological approach to explain the mechanism of CHL in the treatment of acne has not been explored. In this study, active components and action ta...

Radiosensitization with Gadolinium Chelate-Coated Gold Nanoparticles Prevents Aggressiv...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844821
International Journal of Nanomedicine; Durand M, Chateau A et. al.

Jan 21st, 2023 - This study aimed to evaluate the radiosensitizing potential of Au@DTDTPA(Gd) nanoparticles when combined with conventional external X-ray irradiation (RT) to treat GBM. Complementary biological models based on U87 spheroids including conventional 3D invasion assay, organotypic brain slice cultures, chronic cranial window model were implemented to investigate the impact of RT treatments (10 Gy s...

13‑cis‑retinoic acid inhibits the self‑renewal, migration, invasion and adhesion of cho...
https://doi.org/10.3892/ijmm.2023.5223
International Journal of Molecular Medicine; Butsri S, Kukongviriyapan V et. al.

Jan 21st, 2023 - 13‑cis‑retinoic acid (13CRA), a Food and Drug Administration‑approved drug for severe acne, is currently being investigated for its potential use in skin cancer prevention. 13CRA has been reported to exhibit antitumor effects against various types of cancer cells, both in vitro and in vivo. However, to the best of our knowledge, no information is yet available regarding the effects of 13CRA on ...

A new WHO bottle bioassay method to assess the susceptibility of mosquito vectors to pu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863080
Parasites & Vectors; Corbel V, Kont MD et. al.

Jan 21st, 2023 - The continued spread of insecticide resistance in mosquito vectors of malaria and arboviral diseases may lead to operational failure of insecticide-based interventions if resistance is not monitored and managed efficiently. This study aimed to develop and validate a new WHO glass bottle bioassay method as an alternative to the WHO standard insecticide tube test to monitor mosquito susceptibilit...

Precision Effects of Glibenclamide on MRI Endophenotypes in Clinically Relevant Murine ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848216
Critical Care Medicine; Zusman BE, Wu Y et. al.

Jan 21st, 2023 - Addressing traumatic brain injury (TBI) heterogeneity is increasingly recognized as essential for therapy translation given the long history of failed clinical trials. We evaluated differential effects of a promising treatment (glibenclamide) based on dose, TBI type (patient selection), and imaging endophenotype (outcome selection). Our goal to inform TBI precision medicine is contextually time...

Interferon-induced restriction of Chikungunya virus infection.
https://doi.org/10.1016/j.antiviral.2022.105487
Antiviral Research; Suzuki Y

Jan 20th, 2023 - Chikungunya virus (CHIKV) is an enveloped RNA virus that causes Chikungunya fever (CHIKF), which is transmitted to humans through the bite of infected Aedes mosquitos. Although CHIKVF had been regarded as an endemic disease in limited regions of Africa and Asia, the recent global reemergence of CHIKV heightened awareness of this infectious disease, and CHIKV infection is currently considered an...

A novel Mcl-1 inhibitor synergizes with venetoclax to induce apoptosis in cancer cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854187
Molecular Medicine (Cambridge, Mass.); Zhao T, He Q et. al.

Jan 20th, 2023 - Evading apoptosis by overexpression of anti-apoptotic Bcl-2 family proteins is a hallmark of cancer cells and the Bcl-2 selective inhibitor venetoclax is widely used in the treatment of hematologic malignancies. Mcl-1, another anti-apoptotic Bcl-2 family member, is recognized as the primary cause of resistance to venetoclax treatment. However, there is currently no Mcl-1 inhibitor approved for ...

Reverse genetic systems of SARS-CoV-2 for antiviral research.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776485
Antiviral Research; Kurhade C, Xie X et. al.

Jan 20th, 2023 - Reverse genetic systems are widely used to engineer recombinant viruses with desired mutations. In response to the COVID-19 pandemic, four types of reverse genetic systems have been developed for SARS-CoV-2: (i) a full-length infectious clone that can be used to prepare recombinant SARS-CoV-2 at biosafety level 3 (BSL3), (ii) a trans-complementation system that can be used to produce single-rou...

Myeloid-derived suppressor cells inhibit natural killer cells in myelodysplastic syndro...
https://doi.org/10.1080/16078454.2023.2166333
Hematology (Amsterdam, Netherlands); Yue J, Li J et. al.

Jan 19th, 2023 - This experiment will explore the role of TIGIT/PVR signaling pathway in the pathogenesis of MDS immune tolerance through in vitro co-culture of NK cells and MDSC cells. Flow cytometry was used to detect the expression percentage of MDSCs and CD155 on MDSCs in the bone marrow of MDS patients and controls. The expression of NK cell surface receptors (NKG2D, NKp30, NKp46), secreted cytokines (perf...

Immune checkpoint blockade in glioblastoma: from tumor heterogeneity to personalized tr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843050
The Journal of Clinical Investigation; Arrieta VA, Dmello C et. al.

Jan 18th, 2023 - Immune checkpoint blockade (ICB) has revolutionized modern cancer therapy, arousing great interest in the neuro-oncology community. While several reports show that subsets of patients with glioma exhibit durable responses to immunotherapy, the efficacy of this treatment has not been observed for unselected patient populations, preventing its broad clinical implementation for gliomas and gliobla...

Impact of insecticide resistance on malaria vector competence: a literature review.
https://doi.org/10.1186/s12936-023-04444-2
Malaria Journal; Suh PF, Elanga-Ndille E et. al.

Jan 18th, 2023 - Since its first report in Anopheles mosquitoes in 1950s, insecticide resistance has spread very fast to most sub-Saharan African malaria-endemic countries, where it is predicted to seriously jeopardize the success of vector control efforts, leading to rebound of disease cases. Supported mainly by four mechanisms (metabolic resistance, target site resistance, cuticular resistance, and behavioura...