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About 106,643 results

Doxycycline sensitizes renal cell carcinoma to chemotherapy by preferentially inhibitin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521774
The Journal of International Medical Research; Wang B, Ao J et. al.

Oct 14th, 2021 - The anti-cancer activity of doxycycline has been reported in many cancers but not renal cell carcinoma (RCC). This study aimed to determine the efficacy of doxycycline alone and in combination with paclitaxel and analyze the underlying mechanism in RCC. Proliferation, colony formation and apoptosis assays were performed in RCC cell lines after drug treatments. An RCC xenograft mouse model was g...

Virulence Factors Associated With Escherichia coli Bacteremia and Urinary Tract Infection.
https://doi.org/10.3343/alm.2022.42.2.203
Annals of Laboratory Medicine; Kim B, Kim JH et. al.

Oct 13th, 2021 - Extraintestinal pathogenic Escherichia coli (ExPEC) causes various infections, including urinary tract infection (UTI), sepsis, and neonatal meningitis. ExPEC strains have virulence factors (VFs) that facilitate infection by allowing bacterial cells to migrate into and multiply within the host. We compared the microbiological characteristics of ExPEC isolates from blood and urine specimens from...

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry ...
https://doi.org/10.1073/pnas.2108728118
Proceedings of the National Academy of Sciences of the Un... Mahoney M, Damalanka VC et. al.

Oct 13th, 2021 - The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug discovery. This protease activates the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and of other coronaviruses and is essential for viral spread in the lung. Utilizing rational structure-based drug design (SBDD) coupled to substrate specificity screening of TMPRSS2, we ha...

Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504098
Clinical Epigenetics; Saiz ML, De Diego ML et. al.

Oct 13th, 2021 - SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) and neuropilin-1 (NRP1) receptors for entry into cells, and the serine protease TMPRSS2 for S protein priming. Inhibition of protease activity or the engagement with ACE2 and NRP1 receptors has been shown to be an effective strategy for blocking infectivity and viral spreading. Valproic acid (VPA; 2-propylpentanoic acid) is an epigeneti...

Inhaled D-Ala2-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Gro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490075
Journal of Immunology Research; Karkischenko VN, Skvortsova VI et. al.

Oct 8th, 2021 - COVID-19 is a respiratory infection caused by the SARS-CoV-2 virus that can rapidly escalate to life-threatening pneumonia and acute respiratory distress syndrome (ARDS). Recently, extracellular high mobility group box 1 (HMGB1) has been identified as an essential component of cytokine storms that occur with COVID-19; HMGB1 levels correlate significantly with disease severity. Thus, the modulat...

Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490365
Nature Communications; Ferren M, Favède V et. al.

Oct 6th, 2021 - SARS-CoV-2 has caused a global pandemic of COVID-19 since its emergence in December 2019. The infection causes a severe acute respiratory syndrome and may also spread to central nervous system leading to neurological sequelae. We have developed and characterized two new organotypic cultures from hamster brainstem and lung tissues that offer a unique opportunity to study the early steps of viral...

Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition.
https://doi.org/10.1073/pnas.2113401118
Proceedings of the National Academy of Sciences of the Un... Liu X, Verma A et. al.

Oct 2nd, 2021 - The coronaviruses responsible for severe acute respiratory syndrome (SARS-CoV), COVID-19 (SARS-CoV-2), Middle East respiratory syndrome-CoV, and other coronavirus infections express a nucleocapsid protein (N) that is essential for viral replication, transcription, and virion assembly. Phosphorylation of N from SARS-CoV by glycogen synthase kinase 3 (GSK-3) is required for its function and inhib...

Rapalink-1 and Hydroxychloroquine Exhibit an Additive Effect in Undifferentiated Pleomo...
https://doi.org/10.21873/anticanres.15302
Anticancer Research; Negayama T, Ishibashi Y et. al.

Oct 2nd, 2021 - Advanced undifferentiated pleomorphic sarcoma (UPS) has a poor prognosis and there are few treatments that can improve overall survival. Recently, Rapalink-1, a third-generation mammalian target of rapamycin (mTOR) kinase inhibitor, has been developed and shown to be effective against other tumours. However, mTOR inhibitors have been shown to induce autophagy and resistance to anti-cancer drugs...

The Thioredoxin Reductase Inhibitor Auranofin Suppresses Pulmonary Metastasis of Osteos...
https://doi.org/10.21873/anticanres.15308
Anticancer Research; Kinoshita H, Shimozato O et. al.

Oct 2nd, 2021 - Auranofin (AUR), a thioredoxin reductase (TXNRD) inhibitor, shows anticancer activity against several cancers. This study investigated the effects of AUR on the local progression and pulmonary metastasis of osteosarcoma (OS). Publicly available expression cohorts were analysed to study the relationship between TXNRD-2 expression and the survival of patients with OS. The murine OS cell line LM8 ...

CD44 Is Involved in Sunitinib Resistance and Poor Progression-free Survival After Sunit...
https://doi.org/10.21873/anticanres.15301
Anticancer Research; Sekino Y, Takemoto K et. al.

Oct 2nd, 2021 - Sunitinib continues to be administered as a first-line therapeutic agent in metastatic renal cell carcinoma (mRCC). This study aimed to examine the role of CD44 in sunitinib resistance and as a predictive marker in mRCC. We analyzed the effect of CD44 knockdown on sunitinib resistance in RCC cell lines using WST-1 assays. CD44 expression in mRCC patients treated with first-line sunitinib was de...

Ponatinib Exerts an Inhibitory Effect on Collagen-induced Platelet Aggregation and Gene...
https://doi.org/10.21873/anticanres.15300
Anticancer Research; Mezei G, Batár P et. al.

Oct 2nd, 2021 - BCR-ABL tyrosine kinase inhibitors (TKIs) are exceptionally effective drugs in the treatment of chronic myeloid leukemia, nevertheless, TKIs have also an effect on platelets. We aimed to investigate the effect of a third-generation TKI, ponatinib on platelet functions. Collagen-induced platelet aggregation and coated-platelet formation were examined using in vitro and in ex vivo samples of pati...

Intracellular IL-33 Attenuates Extracellular IL-33-induced Cholangiocarcinoma Cell Prol...
https://doi.org/10.21873/anticanres.15305
Anticancer Research; Yangngam S, Thongchot S et. al.

Oct 2nd, 2021 - The functions of interleukin 33 (IL-33) in cholangiocarcinoma (CCA) are unclear. This study aimed to evaluate the roles of IL-33 in CCA progression. The effect of intracellular IL-33 using shIL-33 knocked down KKU-055 (IL-33KD-KKU-055) compared to parental (Pa) KKU-055 and extracellular IL-33 using recombinant human IL-33 (rhIL-33) treatment on the proliferation and invasion of CCA cells grown ...

Plumbagin Induces Cytotoxicity via Loss of Mitochondrial Membrane Potential and Caspase...
https://doi.org/10.21873/anticanres.15287
Anticancer Research; Gharbaran R, Shi C et. al.

Oct 2nd, 2021 - We investigated the cytotoxic effects of plumbagin on metastatic retinoblastoma, using the highly metastatic cell line Y79. Effect of plumbagin on cell growth was assessed with water-soluble tetrazolium 1 (WST-1) cell proliferation assay and automated hemocytometry with trypan blue-exclusion assay. Cell death was studied with acridine orange/ethidium bromide live-dead assay and annexin-V-fluore...

Synergistic Antitumor Effect of Taxanes and CDK4/6 Inhibitor in Lung Cancer Cells and M...
https://doi.org/10.21873/anticanres.15296
Anticancer Research; Son KH, Kim MY et. al.

Oct 2nd, 2021 - LY2835219 (LY), a novel CDK4/6 inhibitor, prevents cell proliferation through G1 arrest. Docetaxel (DTX) and paclitaxel (PTX) are cytotoxic drugs targeting tubulin-mediated apoptotic cell death via G2/M arrest. We evaluated the antitumor effects of DTX/PTX and LY individually and in combination in lung adenocarcinoma cells with or without KRAS mutations and xenograft mice harboring KRAS mutatio...

Evaluation of electrostatic sprayers and foggers for the application of disinfectants i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483385
PloS One; Wood JP, Magnuson M et. al.

Oct 1st, 2021 - Although research has shown that the COVID-19 disease is most likely caused by airborne transmission of the SARS-CoV-2 virus, disinfection of potentially contaminated surfaces is also recommended to limit the spread of the disease. Use of electrostatic sprayers (ESS) and foggers to rapidly apply disinfectants over large areas or to complex surfaces has emerged with the COVID-19 pandemic. ESSs a...

Protective Effect of Isopulegol in Alleviating Neuroinflammation in Lipopolysaccharide-...
https://doi.org/10.1615/JEnvironPatholToxicolOncol.2021038944
Journal of Environmental Pathology, Toxicology and Oncolo... Kang B, Li N et. al.

Sep 30th, 2021 - Parkinson's disease (PD) is the most prevalent disease linked with age-associated neuronal degeneration. Phytotherapeutic compounds or agents have gained increased importance because of their increased specificity and minimal side effects. Isopulegol, a monoterpene, was utilized in the present study because of its wide range of therapeutic properties. Our aim was to examine the underlying mecha...

Targeting novel coronavirus SARS-CoV-2 spike protein with phytoconstituents of Momordic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474883
Journal of Ovarian Research; Singh SK, Singh S et. al.

Sep 29th, 2021 - Infections by the SARS-CoV-2 virus causing COVID-19 are presently a global emergency. The current vaccination effort may reduce the infection rate, but strain variants are emerging under selection pressure. Thus, there is an urgent need to find drugs that treat COVID-19 and save human lives. Hence, in this study, we identified phytoconstituents of an edible vegetable, Bitter melon (Momordica ch...

Bioprospecting for Novel Heat Shock Protein Modulators: The New Frontier for Antimalari...
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Advances in Experimental Medicine and Biology; Anokwuru C, Makumire S et. al.

Sep 28th, 2021 - Heat shock proteins are conserved molecules whose main role is to facilitate protein folding. However, they are also implicated in protein trafficking, protein assembly/disassembly, and functional maturation of proteins implicated in several biochemical pathways, including signal transduction. The role of heat shock proteins in the development of malaria parasites has recently become a subject ...

Heat Shock Proteins as Targets for Novel Antimalarial Drug Discovery.
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Advances in Experimental Medicine and Biology; Daniyan MO

Sep 28th, 2021 - Plasmodium falciparum, the parasitic agent that is responsible for a severe and dangerous form of human malaria, has a history of long years of cohabitation with human beings with attendant negative consequences. While there have been some gains in the fight against malaria through the application of various control measures and the use of chemotherapeutic agents, and despite the global decline...

Synergistic efficacy of inhibiting MYCN and mTOR signaling against neuroblastoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474810
BMC Cancer; Kling MJ, Griggs CN et. al.

Sep 28th, 2021 - Neuroblastoma (NB) patients with MYCN amplification or overexpression respond poorly to current therapies and exhibit extremely poor clinical outcomes. PI3K-mTOR signaling-driven deregulation of protein synthesis is very common in NB and various other cancers that promote MYCN stabilization. In addition, both the MYCN and mTOR signaling axes can directly regulate a common translation pathway th...