×
About 119,718 results

"PFH/AGM-CBA/HSV-TK/LIPOSOME-Affibody": Novel Targeted Nano Ultrasound Contrast Agents ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124479
Drug Design, Development and Therapy; Zhou H, Liu H et. al.

May 26th, 2022 - Gastric cancer is one of the most lethal malignancies in the world. However, the current research on the diagnosis and treatment of nano-ultrasound contrast agents in the field of tumor is mostly focused on breast cancer, ovarian cancer, prostate cancer, liver cancer, etc. Due to the interference of gas in the stomach, there is no report on the treatment of gastric cancer. Herpes simplex virus ...

Emergence of multi-drug-resistant Mycobacterium tuberculosis in Niger: A snapshot based...
https://doi.org/10.1371/journal.pntd.0010443
PLoS Neglected Tropical Diseases; Harouna Hamidou Z, Morsli M et. al.

May 26th, 2022 - Among other West African countries experiencing the high endemicity of deadly tuberculosis, the situation in Niger is poorly evidenced by microbiological investigations. The study of 42 isolates of Mycobacterium tuberculosis from Niger by whole genome sequencing using Illumina iSeq technology yielded four M. tuberculosis lineages: Indo-Oceanic L1 (n = 1) (2.3%), East-Asian (n = 1) (2.3%), East-...

Transcriptomics-Based Investigation of Molecular Mechanisms Underlying Apoptosis Induce...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124502
International Journal of Nanomedicine; Alsagaby SA

May 26th, 2022 - Zinc oxide nanoparticles (ZnO NPs) show anti-cancer activity. Diffuse Large B-cell Lymphoma (DLBCL) is a type of B-cell malignancies with unsatisfying treatment outcomes. This study was set to assess the potential of ZnO NPs to selectively induce apoptosis in human DLBCL cells (OCI-LY3), and to describe possible molecular mechanisms of action. The impact of ZnO NPs on DLBCL cells and normal per...

Evaluating the Efficacy of EGFR-TKIs Combined With Radiotherapy in Advanced Lung Adenoc...
https://doi.org/10.1177/15330338221100358
Technology in Cancer Research & Treatment; Wang Y, Yu W et. al.

May 25th, 2022 - Objective: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been recommended as the first-line treatment for advanced lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutation. This study retrospectively evaluated patients' survival and related prognostic factors from single-center, real-world data. Methods: From January 2015 to December 2020, patient...

Discovery of new drug indications for COVID-19: A drug repurposing approach.
https://doi.org/10.1371/journal.pone.0267095
PloS One; Kumari P, Pradhan B et. al.

May 25th, 2022 - The outbreak of coronavirus health issues caused by COVID-19(SARS-CoV-2) creates a global threat to public health. Therefore, there is a need for effective remedial measures using existing and approved therapies with proven safety measures has several advantages. Dexamethasone (Pubchem ID: CID0000005743), baricitinib(Pubchem ID: CID44205240), remdesivir (PubchemID: CID121304016) are three gener...

Human tumor necrosis factor alpha affects the egg-laying dynamics and glucose metabolis...
https://doi.org/10.1186/s13071-022-05278-8 10.1016/j.idc.2012.03.004 10.1186/1756-3305-4-203 10.1016/S0962-8924(01)02064-5 10.1038/356604a0 10.1016/S0742-8413(96)00137-5 10.1017/S0022149X00016291 10.1128/IAI.67.5.2201-2208.1999 10.1016/j.ijpara.2003.10.010 10.1371/journal.pntd.0000556 10.1007/s00436-015-4812-5 10.1515/ap-2017-0019 10.1128/JVI.77.13.7261-7280.2003 10.2307/3001913 10.1177/00164402062003002 10.1371/journal.ppat.1007817 10.1016/1043-4666(94)90003-5 10.1016/j.tibtech.2018.12.002 10.1373/clinchem.2008.112797 10.1371/journal.pbio.3000254
Parasites & Vectors; Lopes-Junior EH, Bertevello CR et. al.

May 25th, 2022 - Several studies have described the effects of human tumor necrosis factor alpha (hTNF-α) on Schistosoma mansoni. hTNF-α affects the worm's development, metabolism, egg-laying, gene expression and protein phosphorylation. The available data on the influence of hTNF-α on egg-laying in S. mansoni are controversial, but understanding the mechanism of egg-laying regulation in this species is essenti...

Identification of Human Case of Avian Influenza A(H5N1) Infection, India.
https://doi.org/10.3201/eid2806.212246
Emerging Infectious Diseases; Potdar V, Brijwal M et. al.

May 25th, 2022 - A 11-year-old boy with acute myeloid leukemia was brought for treatment of severe acute respiratory infection in the National Capital Region, New Delhi, India. Avian influenza A(H5N1) infection was laboratory confirmed. Complete genome analysis indicated hemagglutinin gene clade 2.3.2.1a. We found the strain to be susceptible to amantadine and neuraminidase inhibitors.

The SARS-CoV-2 main protease doesn't induce cell death in human cells in vitro.
https://doi.org/10.1371/journal.pone.0266015
PloS One; Komissarov A, Karaseva M et. al.

May 25th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19) which has extremely rapidly spread worldwide. In order to develop the effective antiviral therapies, it is required to understand the molecular mechanisms of the SARS-CoV-2 pathogenesis. The main protease, or 3C-like protease (3CLpro), plays the essential role in the coronavirus repl...

Targeting TROY-mediated P85a/AKT/TBX3 signaling attenuates tumor stemness and elevates ...
https://doi.org/10.1186/s13046-022-02401-6 10.1097/MD.0000000000004764 10.3389/fendo.2019.00772 10.3389/fgene.2019.00711 10.1016/j.stem.2015.02.015 10.7150/jca.44697 10.1152/ajpgi.00465.2005 10.1073/pnas.1912146117 10.1073/pnas.1715911114 10.1152/physrev.00045.2017 10.1053/j.gastro.2012.10.048 10.1073/pnas.1714145115 10.1016/j.cell.2013.09.008 10.1002/ijc.28839 10.1158/1541-7786.MCR-13-0008 10.1038/nature08113 10.3892/ol.2016.5296 10.1002/hep.29312 10.1186/s13059-014-0550-8 10.1038/ncomms4662 10.1016/j.semcancer.2018.09.010 10.1016/j.gene.2019.144223 10.1093/nar/gky1079 10.1016/j.trecan.2019.02.009 10.1038/s41392-020-0187-x 10.1136/gutjnl-2017-315402 10.1007/978-1-0716-0327-7_17 10.3892/ol.2017.6497 10.1002/hep.31792 10.1586/eci.13.14 10.1158/0008-5472.CAN-09-3399 10.1016/j.molonc.2013.01.005 10.1186/s13058-016-0740-2 10.1186/s13045-019-0770-1
Journal of Experimental & Clinical Cancer Research : CR; Liu B, Fang X et. al.

May 25th, 2022 - Previous in vitro hepatocyte differentiation model showed that TROY was specifically expressed in liver progenitor cells and a small proportion of hepatocellular carcinoma cells, suggesting that TROY may participate in hepatocellular carcinoma (HCC) stemness regulation. Here, we aim to investigate the role and mechanism of TROY in HCC pathogenesis. Bioinformatics analysis of the TCGA dataset ha...

The effects of Epigallocatechin-3-gallate and Dabrafenib combination on apoptosis and t...
https://doi.org/10.1007/s12032-022-01688-x
Medical Oncology (Northwood, London, England); Birden N, Selvi Gunel N et. al.

May 23rd, 2022 - Anaplastic thyroid cancer cases with poor prognosis are associated with epigenetic modifications such as abnormal DNA methylation. Epigallocathesin-3-gallate (EGCG) is a polyphenol compound of green tea that is still under investigation on its role in cancer prevention. EGCG is known as an epigenetic diet in DNA methyltransferase inhibitor. The cytotoxic effects of Dabrafenib, EGCG, and dabrafe...

Effects of arsenic on the topology and solubility of promyelocytic leukemia (PML)-nucle...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122205
PloS One; Hirano S, Udagawa O

May 21st, 2022 - Promyelocytic leukemia (PML) proteins are involved in the pathogenesis of acute promyelocytic leukemia (APL). Trivalent arsenic (As3+) is known to cure APL by binding to cysteine residues of PML and enhance the degradation of PML-retinoic acid receptor α (RARα), a t(15;17) gene translocation product in APL cells, and restore PML-nuclear bodies (NBs). The size, number, and shape of PML-NBs vary ...

eEF1A2 knockdown impairs neuronal proliferation and inhibits neurite outgrowth of diffe...
https://doi.org/10.1097/WNR.0000000000001791
Neuroreport Rumpansuwon K, Prommahom A et. al.

May 21st, 2022 - The translation elongation factor-1, alpha-2 (eEF1A2) plays an important role in protein synthesis. Mutations in this gene have been described in individuals with neurodevelopmental disorders. Here, we silenced the expression of eEFA2 in human SH-SY5Y neuroblastoma cells and observed its roles in neuronal proliferation and differentiation upon induction with retinoic acid. eEF1A2 were silenced ...

Paediatric Osteomyelitis and Septic Arthritis Pathogen Distribution and Antimicrobial R...
https://doi.org/10.1093/tropej/fmac038
Journal of Tropical Pediatrics; Zhang T, Yu S et. al.

May 21st, 2022 - The epidemiological characteristics of the common pathogens underlying acute haematogenous osteoarticular infection (AHOI) and their resistance to drugs have temporal and regional differences. To determine the antimicrobial treatment most effective for culture-negative AHOI patients and those without bacterial cultures. Retrospective analysis of clinical data of children with AHOI who were cult...

Pirtobrutinib inhibits wild-type and mutant Bruton's tyrosine kinase-mediated signaling...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123190
Blood Cancer Journal; Aslan B, Kismali G et. al.

May 21st, 2022 - Pirtobrutinib (LOXO-305), a reversible inhibitor of Bruton's tyrosine kinase (BTK), was designed as an alternative strategy to treat ibrutinib-resistant disease that develops due to C481 kinase domain mutations. The clinical activity of pirtobrutinib has been demonstrated in CLL, but the mechanism of action has not been investigated. We evaluated pirtobrutinib in 4 model systems: first, MEC-1, ...

Highly prevalent MDR, frequently carrying virulence genes and antimicrobial resistance ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119451
PloS One; Long L, You L et. al.

May 20th, 2022 - Salmonella enterica serovar 4,[5],12:i:-, a monophasic variant of Salmonella Typhimurium lacking the phase 2 flagellin, is one of the common serotypes causing Salmonellosis worldwide. However, information on Salmonella serovar 4,[5],12:i:- from Guizhou Province has lacked so far. This study aimed to investigate the antimicrobial resistance, the presence of antimicrobial resistance genes and vir...

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119441
PLoS Pathogens; Belouzard S, Machelart A et. al.

May 20th, 2022 - Drug repurposing has the advantage of shortening regulatory preclinical development steps. Here, we screened a library of drug compounds, already registered in one or several geographical areas, to identify those exhibiting antiviral activity against SARS-CoV-2 with relevant potency. Of the 1,942 compounds tested, 21 exhibited a substantial antiviral activity in Vero-81 cells. Among them, clofo...

Clinical epidemiology and high genetic diversity amongst Cryptococcus spp. isolates inf...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119562
PloS One; Bive BZ, Sacheli R et. al.

May 20th, 2022 - Neuromeningeal cryptococcosis (NMC) is a life-threatening opportunistic infection in advanced HIV disease patients (AHDP). It is caused by Cryptococcus spp. complexes and mainly occurs in sub-Saharan Africa. In this study, we performed molecular characterization and antifungal susceptibility profiling of Cryptococcus isolates from AHDP in Kinshasa (DRC). Additionally, we investigated a possible...

Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviru...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119983
Nature Communications; Zeng L, Liu Y et. al.

May 20th, 2022 - A major challenge in coronavirus vaccination and treatment is to counteract rapid viral evolution and mutations. Here we demonstrate that CRISPR-Cas13d offers a broad-spectrum antiviral (BSA) to inhibit many SARS-CoV-2 variants and diverse human coronavirus strains with >99% reduction of the viral titer. We show that Cas13d-mediated coronavirus inhibition is dependent on the crRNA cellular spat...

Rapid molecular diagnostics of tuberculosis resistance by targeted stool sequencing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118838
Genome Medicine; Sibandze DB, Kay A et. al.

May 19th, 2022 - Stool is an important diagnostic specimen for tuberculosis in populations who struggle to provide sputum, such as children or people living with HIV. However, the culture of Mycobacterium tuberculosis (M. tuberculosis) complex strains from stool perform poorly. This limits the opportunity for phenotypic drug resistance testing with this specimen. Therefore, reliable molecular methods are urgent...

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115865
The Cochrane Database of Systematic Reviews; Pillay S, Steingart KR et. al.

May 19th, 2022 - The World Health Organization (WHO) End TB Strategy stresses universal access to drug susceptibility testing (DST). DST determines whether Mycobacterium tuberculosis bacteria are susceptible or resistant to drugs. Xpert MTB/XDR is a rapid nucleic acid amplification test for detection of tuberculosis and drug resistance in one test suitable for use in peripheral and intermediate level laboratori...