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About 123,318 results

Omalizumab therapy for bullous pemphigoid.
https://doi.org/10.1016/j.jaad.2014.04.053
Journal of the American Academy of Dermatology; Yu KK, Crew AB et. al.

Jun 23rd, 2014 - Bullous pemphigoid (BP) responds to a variety of immunosuppressive agents and usually controls, but does not cure, the disease. Omalizumab, Food and Drug Administration-approved for asthma, selectively suppresses the activity of IgE, an important immunoglobulin in the pathogenesis of BP. We wished to determine if systemic omalizumab would have a therapeutic effect in patients with BP. We treate...

Inhibition of the mTORC pathway in the antiphospholipid syndrome.
https://doi.org/10.1056/NEJMoa1312890
The New England Journal of Medicine; Canaud G, Bienaimé F et. al.

Jul 23rd, 2014 - Although thrombosis is considered the cardinal feature of the antiphospholipid syndrome, chronic vascular lesions are common, particularly in patients with life-threatening complications. In patients who require transplantation, vascular lesions often recur. The molecular pathways involved in the vasculopathy of the antiphospholipid syndrome are unknown, and adequate therapies are lacking. We u...

Spread of artemisinin resistance in Plasmodium falciparum malaria.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143591
The New England Journal of Medicine; Ashley EA, Dhorda M et. al.

Jul 30th, 2014 - Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies. Between May 2011 and April 2013, we enrolled 1241 adults and children with acute, uncomplicated falciparum malaria in an open-label trial at 15...

Multidrug-resistant tuberculosis and culture conversion with bedaquiline.
https://doi.org/10.1056/NEJMoa1313865
The New England Journal of Medicine; Diacon AH, Pym A et. al.

Aug 20th, 2014 - Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with accelerated sputum-culture conversion in patients with multidrug-resistant tuberculosis, when added to a preferred background regimen for 8 weeks. In this phase 2b trial, we randomly assigned 160 patients with newly diagnosed, smear-positive, multidrug-resistant tuberculosis to re...

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362521
Nature Medicine; Xing L, Dai Z et. al.

Aug 18th, 2014 - Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in AA are not defined limiting clinical development of rational targeted therapies. Genome-wide association studies (GWAS) implicated ligands for the NKG2D receptor (product of the KLRK1 gene) in disease pathogenesis. Here, we...

Beneficial effects of growth hormone treatment on cognition in children with Prader-Wil...
https://doi.org/10.1210/jc.2012-1182
The Journal of Clinical Endocrinology and Metabolism; Siemensma EP, Tummers-de Lind van Wijngaarden RF et. al.

Apr 17th, 2012 - Knowledge about the effects of GH treatment on cognitive functioning in children with Prader-Willi syndrome (PWS) is limited. Fifty prepubertal children aged 3.5 to 14 yr were studied in a randomized controlled GH trial during 2 yr, followed by a longitudinal study during 4 yr of GH treatment. Cognitive functioning was measured biennially by short forms of the WPPSI-R or WISC-R, depending on ag...

Synergistic activity of rifampicin and ethambutol against slow-growing nontuberculous m...
https://doi.org/10.1016/j.ijantimicag.2013.03.010
International Journal of Antimicrobial Agents; van Ingen J, Hoefsloot W et. al.

May 14th, 2013 - A key issue in the treatment of disease caused by slow-growing nontuberculous mycobacteria is the limited association between in vitro minimum inhibitory concentrations (MICs) of rifampicin and ethambutol alone and the in vivo outcome of treatment with these drugs. Combined susceptibility testing to rifampicin and ethambutol could provide a more realistic view of the efficacy of these drugs. In...

Reviews of anti-infective agents: posaconazole: a broad-spectrum triazole antifungal ag...
https://doi.org/10.1086/523576
Clinical Infectious Diseases : an Official Publication Of... Nagappan V, Deresinski S

Jan 14th, 2008 - Posaconazole is a triazole antifungal agent with a spectrum of activity that includes Candida and Cryptococcus species, many molds, and some endemic fungi. Posaconazole has received US Food and Drug Administration approval for the treatment of oropharyngeal candidiasis, including infections refractory to itraconazole and/or fluconazole. It is also approved as prophylaxis for invasive Aspergillu...

Efficacy and safety of bendamustine for the treatment of patients with recurring Hodgki...
https://doi.org/10.1111/bjh.12120
British Journal of Haematology; Corazzelli G, Angrilli F et. al.

Nov 21st, 2012 - The management of patients with Hodgkin lymphoma (HL) recurring after stem cell transplantation (SCT) and multiply relapsed disease remains challenging. We report on 41 such patients who received bendamustine hydrochloride, a bifunctional mechlorethamine derivative mechanistically unrelated to traditional alkylators, after a median of four prior chemotherapy lines, including SCT in 85% of cases...

Microbiologic characterization and antimicrobial susceptibility of Clostridium tetani i...
https://www.ncbi.nlm.nih.gov/pubmed/19407132
The American Journal of Tropical Medicine and Hygiene; Campbell JI, Lam TM et. al.

May 1st, 2009 - Clostridium tetani is the etiologic agent of the muscle-spasming disease tetanus. Despite an effective vaccine, tetanus is an ongoing problem in some developing countries. Diagnosis by bacterial culture is not done because it is generally unnecessary and the entry of route of the bacteria can be inapparent. We attempted to isolate and evaluate C. tetani from the wounds of 84 patients with tetan...

Endothelial-to-mesenchymal transition in pulmonary hypertension.
https://doi.org/10.1161/CIRCULATIONAHA.114.008750
Circulation Ranchoux B, Antigny F et. al.

Jan 16th, 2015 - The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle actin-expressing cells. In situ evidence of EndoMT in human PAH was obtained by using con...

Deferasirox reduces iron overload significantly in nontransfusion-dependent thalassemia...
https://doi.org/10.1182/blood-2012-02-412692
Blood Taher AT, Porter J et. al.

May 16th, 2012 - Nontransfusion-dependent thalassemia (NTDT) patients may develop iron overload and its associated complications despite receiving only occasional or no transfusions. The present 1-year, randomized, double-blind, placebo-controlled THALASSA (Assessment of Exjade in Nontransfusion-Dependent Thalassemia) trial assessed the efficacy and safety of deferasirox in iron-overloaded NTDT patients. A tota...

Mycobacterium xenopi clinical relevance and determinants, the Netherlands.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570832
Emerging Infectious Diseases; van Ingen J, Boeree MJ et. al.

Mar 7th, 2008 - In the Netherlands, isolation of Mycobacterium xenopi is infrequent, and its clinical relevance is often uncertain. To determine clinical relevance and determinants, we retrospectively reviewed medical files of all patients in the Netherlands in whom M. xenopi was isolated from January 1999 through March 2005 by using diagnostic criteria for nontuberculous mycobacterial infection published by t...

Differential regulation of interleukin 12 and interleukin 23 production in human dendri...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413040
The Journal of Experimental Medicine; Gerosa F, Baldani-Guerra B et. al.

May 20th, 2008 - We analyzed interleukin (IL) 12 and IL-23 production by monocyte-derived dendritic cells (mono-DCs). Mycobacterium tuberculosis H37Rv and zymosan preferentially induced IL-23. IL-23 but not IL-12 was efficiently induced by the combination of nucleotide-binding oligodimerization domain and Toll-like receptor (TLR) 2 ligands, which mimics activation by M. tuberculosis, or by the human dectin-1 li...

Monozygotic transplantation: concerns and opportunities.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678894
American Journal of Transplantation : Official Journal Of... Krishnan N, Buchanan PM et. al.

Sep 23rd, 2008 - We describe the case of a 24-year-old female with end-stage renal disease from focal segmental glomerulosclerosis (FSGS) diagnosed at age 16, who underwent monozygotic triplet transplantation at age 21 from her sister. Monozygosity was established by buccal smear DNA PCR amplification using short tandem repeat (1) profiling for 16 genetic alleles. All immunosuppression was discontinued by 1 mon...

Rapid diagnosis of drug resistance to fluoroquinolones, amikacin, capreomycin, kanamyci...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562191
PloS One; Feng Y, Liu S et. al.

Feb 5th, 2013 - There are urgent needs for rapid and accurate drug susceptibility testing of M. tuberculosis. GenoType MTBDRsl is a new molecular kit designed for rapid identification of the resistance to the second-line antituberculosis drugs with a single strip. In recent years, it has been evaluated in many settings, but with varied results. The aim of this meta-analysis was to synthesize the latest data on...

Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines ea...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747203
Proceedings of the National Academy of Sciences of the Un... Ho VT, Vanneman M et. al.

Aug 31st, 2009 - Through an immune-mediated graft-versus-leukemia effect, allogeneic hematopoietic stem cell transplantation (HSCT) affords durable clinical benefits for many patients with hematologic malignancies. Nonetheless, subjects with high-risk acute myeloid leukemia or advanced myelodysplasia often relapse, underscoring the need to intensify tumor immunity within this cohort. In preclinical models, allo...

Continuous versus intermittent infusion of oxacillin for treatment of infective endocar...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681516
Antimicrobial Agents and Chemotherapy; Hughes DW, Frei CR et. al.

Mar 4th, 2009 - Infective endocarditis (IE) is the fourth leading cause of life-threatening infection in the United States and imposes significant morbidity and mortality. The American Heart Association guidelines for the diagnosis and treatment of IE do not address continuous-infusion (CI) oxacillin. This retrospective study compares outcomes between CI oxacillin and intermittent-infusion (II) oxacillin in th...

Exposure to hydroxyurea and pregnancy outcomes in patients with sickle cell anemia.
https://www.ncbi.nlm.nih.gov/pubmed/19860305
Journal of the National Medical Association; Ballas SK, McCarthy WF et. al.

Oct 28th, 2009 - The Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH) was a randomized double-blind placebo-controlled trial to test whether hydroxyurea could reduce the rate of painful crises in adults who had at least 3 painful crises per year. Because hydroxyurea is known to be carcinogenic, mutagenic, and teratogenic in animals, a major inclusion criterion in MSH was the use of contraceptives bo...

PTH(1-84) administration reverses abnormal bone-remodeling dynamics and structure in hy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019384
Journal of Bone and Mineral Research : the Official Journ... Rubin MR, Dempster DW et. al.

Jul 7th, 2011 - Hypoparathyroidism is associated with abnormal structural and dynamic skeletal properties. We hypothesized that parathyroid hormone(1-84) [PTH(1-84)] treatment would restore skeletal properties toward normal in hypoparathyroidism. Sixty-four subjects with hypoparathyroidism were treated with PTH(1-84) for 2 years. All subjects underwent histomorphometric assessment with percutaneous iliac crest...