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About 634,553 results

Lower bevacizumab doses, agents with less systemic exposure may be safer options for ROP
https://www.healio.com/news/ophthalmology/20220203/lower-bevacizumab-doses-agents-with-less-systemic-exposure-may-be-safer-options-for-rop

Feb 3rd, 2022 - WAIKOLOA, Hawaii — Systemic effects of anti-VEGF in retinopathy of prematurity have not been ruled out, so it may be wise to use bevacizumab in lower doses or switch to agents with less systemic exposure, according to one presenter. “The BEAT-ROP study demonstrated a beneficial effect for bevacizumab vs. laser in the treatment of zone I, stage 3+ ROP. But one thing I didn’t like was the complet...

Several pathways under investigation for dry AMD treatment
https://www.healio.com/news/ophthalmology/20220118/several-pathways-under-investigation-for-dry-amd-treatment

Jan 18th, 2022 - WAIKOLOA, Hawaii — Several pathways are under investigation for the treatment of dry age-related macular degeneration, according to a presentation at Retina 2022. “The big issue for us researchers is we don’t have a good animal model to test anything,” Peter K. Kaiser, MD, said. “We don’t have preclinical models that inform us if a drug is going to work or not because the animal that we use are...

Medicare cuts, ASC rates, new FDA-approved drugs: Latest for 2022
https://www.healio.com/news/ophthalmology/20220117/medicare-cuts-asc-rates-new-fdaapproved-drugs-latest-for-2022

Jan 17th, 2022 - WAIKOLOA, Hawaii — Medicare payment changes, ASC payment rates and new FDA approved drugs were a few of the topics discussed in a presentation on 2022 updates for ophthalmic practices at Hawaiian Eye 2022. Paul M. Larson, MBA, MMSC, COMT, CPC, COE, CPMA, a senior consultant from Corcoran Consulting Group, said that the Medicare Physician Fee Schedule was just updated a few weeks ago. “With the ...

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
https://doi.org/10.1002/art.41752
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

Study: Diminished COVID Vaccine Response in Lupus
https://www.medpagetoday.com/rheumatology/lupus/102876

Jan 30th, 2023 - Patients with systemic lupus erythematosus (SLE) showed reduced antibody responses following COVID-19 vaccination, with drugs for the condition such as belimumab (Benlysta) and mycophenolate mofetil (MMF) likely to blame, researchers said. Immunoglobulin G (IgG) titers measured 2 weeks after the second dose of mRNA COVID vaccines were lower by about 20% among 342 lupus patients compared with th...

Identification and validation of pyroptosis-related gene landscape in prognosis and imm...
https://doi.org/10.1186/s13048-022-01065-2
Journal of Ovarian Research; Gao L, Ying F et. al.

Jan 29th, 2023 - Emerging evidence has highlighted the biological significance of pyroptosis in tumor tumorigenesis and progression. Nonetheless, the potential roles of pyroptosis in tumor immune microenvironment and target therapy of ovarian cancer (OC) remain unknown. In this study, with a series of bioinformatic and machine learning approaches, we comprehensively evaluated genetic alterations and transcripto...

Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upr...
https://doi.org/10.1186/s13024-023-00597-5
Molecular Neurodegeneration; Kisler K, Sagare AP et. al.

Jan 29th, 2023 - PICALM is one of the most significant susceptibility factors for Alzheimer's disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium. PICALM endothelial levels are reduced in AD brains. PICALM controls several steps in Aβ transcytosis across the blood-brain barrier (BBB). Its loss from brain endothelium in mice diminishes Aβ clearance at the BBB, which worsens Aβ patho...

Integrated investigation of the clinical implications and targeted landscape for RNA me...
https://doi.org/10.1186/s40001-023-01016-7
European Journal of Medical Research; Zhang J, Gao J et. al.

Jan 29th, 2023 - RNA methylation (RM) is a crucial post-translational modification (PTM) that directs epigenetic regulation. It mostly consists of N1-methyladenosine (m1A), 5-methylcytosine (m5C), N3-methylcytidine (m3C), N6-methyladenosine (m6A), and 2'-O-methylation (Nm). The "writers" mainly act as intermediaries between these modifications and associated biological processes. However, little is known about ...

TRMT6 promotes hepatocellular carcinoma progression through the PI3K/AKT signaling path...
https://doi.org/10.1186/s40001-022-00951-1
European Journal of Medical Research; Ye Y, Liu M et. al.

Jan 29th, 2023 - Hepatocellular carcinoma is one of the most common and deadly cancers. The aim of this study was to elucidate the role of tRNA methyltransferase 6 (TRMT6) during HCC progression. The role of TRMT6 in the progression and prognosis of HCC was confirmed by analysis of online databases and clinical human samples. The effects of up-regulation or down-regulation of TRMT6 on HCC cell proliferation and...

The effects of altered DNA damage repair genes on mutational processes and immune cell ...
https://doi.org/10.1002/cam4.5663
Cancer Medicine; Yuan H, Qing T et. al.

Jan 29th, 2023 - Defects in DNA damage repair (DDR) pathways lead to genomic instability and oncogenesis. DDR deficiency is prevalent in esophageal squamous cell carcinoma (ESCC), but the effects of DDR alterations on mutational processes and tumor immune microenvironment in ECSS remain unclear. Whole-exome and transcriptome sequencing data of 45 ESCC samples from Taizhou, China, were used to identify genomic v...

Identification of EMP1 as a critical gene for cisplatin resistance in ovarian cancer by...
https://doi.org/10.1002/cam4.5637
Cancer Medicine; Zeng Q, Yi C et. al.

Jan 29th, 2023 - Cisplatin resistance is among the main reasons for the poor prognosis of ovarian cancer (OC) patients. Until now, effective biomarkers for predicting cisplatin resistance in OC and specific drugs for reversing this resistance are lacking. This study identified the critical gene associated with cisplatin resistance in OC and provided a potential target for overcoming this resistance. Differentia...

Quantitative systems pharmacology of the eye: Tools and data for ocular QSP.
https://doi.org/10.1002/psp4.12918
CPT: Pharmacometrics & Systems Pharmacology; Kuepfer L, Fuellen G et. al.

Jan 29th, 2023 - Good eyesight belongs to the most-valued attributes of health, and diseases of the eye are a significant healthcare burden. Case numbers are expected to further increase in the next decades due to an aging society. The development of drugs in ophthalmology, however, is difficult due to limited accessibility of the eye, in terms of drug administration and in terms of sampling of tissues for drug...

PRKN/parkin-mediated mitophagy is induced by the probiotics Saccharomyces boulardii and...
https://doi.org/10.1080/15548627.2023.2172873
Autophagy Hawrysh PJ, Gao J et. al.

Jan 29th, 2023 - Mitochondrial impairment is a hallmark feature of neurodegenerative disorders, such as Parkinson disease, and PRKN/parkin-mediated mitophagy serves to remove unhealthy mitochondria from cells. Notably, probiotics are used to alleviate several symptoms of Parkinson disease including impaired locomotion and neurodegeneration in preclinical studies and constipation in clinical trials. There is som...

Drug-drug interactions associated with FLT3 inhibitors for acute myeloblastic leukemia:...
https://doi.org/10.1080/17512433.2023.2174523
Expert Review of Clinical Pharmacology; Solana-Altabella A, Megías-Vericat JE et. al.

Jan 29th, 2023 - FLT3 inhibitors (FLT3i) are drugs in which there is limited experience and not yet enough information on the mechanisms of absorption, transport, and elimination; but especially on the potential drug-drug interactions (DDIs). There are therefore risks in the management of FLT3i DDIs (i.e., sorafenib, ponatinib, crenolanib, midostaurin, quizartinib, and gilteritinib) and ignoring them can compro...

Clinical remission in paired phase two and three studies in inflammatory bowel disease:...
https://doi.org/10.1097/MEG.0000000000002490
European Journal of Gastroenterology & Hepatology; Tandon P, Natt N et. al.

Jan 29th, 2023 - Discrepancies in phase two and three studies can result in significant patient and financial burden, as well as the nonapproval of potentially efficacious drugs. We aimed to determine whether this discrepancy exists for clinical trials in inflammatory bowel disease (IBD). Electronic databases (MEDLINE and Embase) and clinical trial repositories were searched from 1 January 1946 to 12 March 2021...

Iron chelation therapy.
https://doi.org/10.1111/ejh.13935
European Journal of Haematology; Bruzzese A, Martino EA et. al.

Jan 29th, 2023 - Iron overload is a pathological condition resulting from a congenital impairment of its regulation, increased intestinal iron absorption secondary to bone marrow erythroid hyperplasia, or a chronic transfusional regimen. In normal conditions, intracellular and systemic mechanisms contribute to maintaining iron balance. When this complex homeostatic mechanism fails, an iron overload could be pre...

Interleukin-38 suppresses abdominal aortic aneurysm formation in mice by regulating mac...
https://doi.org/10.14814/phy2.15581
Physiological Reports; Kurose S, Matsubara Y et. al.

Jan 29th, 2023 - Macrophages play crucial roles in abdominal aortic aneurysm (AAA) formation through the inflammatory response and extracellular matrix degradation; therefore, regulating macrophages may suppress AAA formation. Interleukin-38 (IL-38) is a member of the IL-1 family, which binds to IL-36 receptor (IL1RL2) and has an anti-inflammation effect. Because macrophages express IL1RL2, we hypothesized that...

Artemether-lumefantrine efficacy among adults on antiretroviral therapy in Malawi.
https://doi.org/10.1186/s12936-023-04466-w
Malaria Journal; Nyangulu W, Mungwira RG et. al.

Jan 29th, 2023 - When people with human immunodeficiency virus (HIV) infection (PWH) develop malaria, they are at risk of poor anti-malarial treatment efficacy resulting from impairment in the immune response and/or drug-drug interactions that alter anti-malarial metabolism. The therapeutic efficacy of artemether-lumefantrine was evaluated in a cohort of PWH on antiretroviral therapy (ART) and included measurem...

Autophagy and podocytopathy.
https://doi.org/10.1093/ndt/gfad024
Nephrology, Dialysis, Transplantation : Official Publicat... Ponticelli C, Moroni G et. al.

Jan 29th, 2023 - Autophagy is a complex process of lysosomal-dependent degradation of unwanted cellular material. In response to endogenous or exogenous stimuli, autophagy is induced and regulated by two kinases: the AMP activated kinase (AMPK) and the mammalian target of rapamycin (mTOR). Cells activated by Unc-51-like kinase 1 (ULK1) form a double membrane complex that sequesters the cargo (phagophore) and el...

Omaveloxolone: An activator of Nrf2 for the treatment of Friedreich's ataxia.
https://doi.org/10.1080/13543784.2023.2173063
Expert Opinion on Investigational Drugs; Profeta V, McIntyre K et. al.

Jan 29th, 2023 - Friedreich ataxia (FRDA) is a rare autosomal recessive degenerative disorder characterized by ataxia, dysarthria, diabetes, cardiomyopathy, scoliosis, and occasionally vision loss in late-stage disease. The discovery of the abnormal gene in FRDA and its product frataxin has provided insight into the pathophysiology and mechanisms of treatment. Although the neurologic phenotype of FRDA is well-d...