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Lower bevacizumab doses, agents with less systemic exposure may be safer options for ROP
https://www.healio.com/news/ophthalmology/20220203/lower-bevacizumab-doses-agents-with-less-systemic-exposure-may-be-safer-options-for-rop

Feb 3rd, 2022 - WAIKOLOA, Hawaii — Systemic effects of anti-VEGF in retinopathy of prematurity have not been ruled out, so it may be wise to use bevacizumab in lower doses or switch to agents with less systemic exposure, according to one presenter. “The BEAT-ROP study demonstrated a beneficial effect for bevacizumab vs. laser in the treatment of zone I, stage 3+ ROP. But one thing I didn’t like was the complet...

Several pathways under investigation for dry AMD treatment
https://www.healio.com/news/ophthalmology/20220118/several-pathways-under-investigation-for-dry-amd-treatment

Jan 18th, 2022 - WAIKOLOA, Hawaii — Several pathways are under investigation for the treatment of dry age-related macular degeneration, according to a presentation at Retina 2022. “The big issue for us researchers is we don’t have a good animal model to test anything,” Peter K. Kaiser, MD, said. “We don’t have preclinical models that inform us if a drug is going to work or not because the animal that we use are...

Medicare cuts, ASC rates, new FDA-approved drugs: Latest for 2022
https://www.healio.com/news/ophthalmology/20220117/medicare-cuts-asc-rates-new-fdaapproved-drugs-latest-for-2022

Jan 17th, 2022 - WAIKOLOA, Hawaii — Medicare payment changes, ASC payment rates and new FDA approved drugs were a few of the topics discussed in a presentation on 2022 updates for ophthalmic practices at Hawaiian Eye 2022. Paul M. Larson, MBA, MMSC, COMT, CPC, COE, CPMA, a senior consultant from Corcoran Consulting Group, said that the Medicare Physician Fee Schedule was just updated a few weeks ago. “With the ...

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
https://doi.org/10.1002/art.41752
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line
https://www.mdpi.com/1467-3045/44/3/73/htm
Current Issues in Molecular Biology; Aldén M, .

Feb 25th, 2022 - Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro.

Light-intensity and moderate-to-vigorous intensity physical activity among older adult ...
https://doi.org/10.1002/cam4.4841
Cancer Medicine; Gordon BR, Caru M et. al.

May 28th, 2022 - With an aging population, rising incidence of breast cancer, improved survival rates, and obesity epidemic, there will be a growing population of older adult breast cancer survivors with obesity. This complex population, often with multimorbidity, is at risk for several poor health outcomes, including recurrence, cardiovascular disease, dementia, and diabetes, and a number of deleterious sympto...

Social deficits in BTBR T+ Itpr3tf/J mice vary with ecological validity of the test.
https://doi.org/10.1111/gbb.12814
Genes, Brain, and Behavior; Winiarski M, Kondrakiewicz L et. al.

May 28th, 2022 - Translational value of mouse models of neuropsychiatric disorders depends heavily on the accuracy with which they replicate symptoms observed in the human population. In mouse models of autism spectrum disorder (ASD) these include, among others, social affiliation, and communication deficits as well as impairments in understanding and perception of others. Most studies addressing these issues i...

Pharmacologic Treatment and Management of Bipolar Disorder in Adolescents.
https://doi.org/10.1080/14656566.2022.2083954
Expert Opinion on Pharmacotherapy; Elsayed OH, Pahwa M et. al.

May 28th, 2022 - The importance of the appropriate therapeutic interventions in children and adolescents with bipolar disorder (BD) cannot be overstated since treatment choices and their consequences may have effects into adulthood. Randomized clinical trials (RCTs) investigating treatment of mania, bipolar depression, and maintenance in adolescents with BD are reviewed. When RCTs are not available or are inade...

Depression, diabetes, comorbid depression and diabetes and risk of all-cause and cause-...
https://doi.org/10.1007/s00125-022-05723-4 10.1201/9780429492259
Diabetologia Prigge R, Wild SH et. al.

May 28th, 2022 - The aim of this study was to investigate the risks of all-cause and cause-specific mortality among participants with neither, one or both of diabetes and depression in a large prospective cohort study in the UK. Our study population included 499,830 UK Biobank participants without schizophrenia and bipolar disorder at baseline. Type 1 and type 2 diabetes and depression were identified using sel...

Impact of Body Mass Index and Sarcopenia on Short- and Long-Term Outcomes After Esophag...
https://doi.org/10.1245/s10434-022-11944-z 10.1097/SLA.0b013e31821111b5 10.1093/annonc/mdx810 10.1007/s00432-014-1878-x 10.1038/bjc.2013.666 10.1097/MD.0000000000004204 10.1007/s11605-014-2686-y 10.1111/1759-7714.12340 10.1159/000453044 10.1245/s10434-013-3073-8 10.1097/SLA.0000000000002252 10.21873/anticanres.14060 10.1093/dote/doy104 10.1016/j.ejso.2016.11.015 10.1038/s41598-017-14147-9 10.1097/EDE.0b013e3181577654 10.1245/s10434-017-6077-y 10.1016/j.jtcvs.2018.06.098 10.1007/s10047-019-01108-4 10.1111/codi.12805 10.7570/jomes.2019.28.1.40 10.1097/EJA.0000000000000118 10.1016/j.surg.2013.12.001 10.1016/j.athoracsur.2016.04.005 10.1007/s10388-019-00670-3 10.1097/SLA.0000000000002555 10.1016/S1470-2045(08)70153-0 10.1016/j.clnu.2015.05.011 10.1016/j.cell.2011.02.013 10.1016/j.cell.2010.01.025 10.1093/ajcn/80.1.193 10.1128/mBio.01032-13 10.1093/eurheartj/ehq448 10.1016/j.ccell.2014.09.003 10.1016/j.clnu.2009.12.011 10.1016/j.ebiom.2019.10.034 10.1093/jnci/dju124 10.1016/j.amjmed.2007.05.011 10.1510/icvts.2010.256677 10.1212/WNL.0b013e318266fad1 10.1161/STROKEAHA.110.593434 10.1038/ijo.2011.187 10.1016/j.clnu.2009.12.004 10.1093/ageing/afy169 10.1002/jcsm.12221
Annals of Surgical Oncology; Kim GW, Nam JS et. al.

May 28th, 2022 - The effects of specific body mass index (BMI) category and sarcopenia within each BMI category on outcomes in patients undergoing esophageal surgery with esophageal squamous cell carcinoma have not been thoroughly examined. This study included 1141 patients. Sarcopenia was determined with a total psoas muscle cross-sectional area at the level of the third lumbar vertebra in computed tomography....

High-Density Optical Coherence Tomography Analysis Provides Insights Into Early/Interme...
https://doi.org/10.1167/iovs.63.5.36
Investigative Ophthalmology & Visual Science; Trinh M, Kalloniatis M et. al.

May 28th, 2022 - To topographically map all of the thickness differences in individual retinal layers between early/intermediate age-related macular degeneration (AMDearly/AMDint) and normal eyes and to determine interlayer relationships. Ninety-six AMDtotal (48 AMDearly and 48 AMDint) and 96 normal eyes from 192 participants were propensity-score matched by age, sex, and refraction. Retrospective optical coher...

Experiences of persons with Multiple Sclerosis with lifestyle adjustment-A qualitative ...
https://doi.org/10.1371/journal.pone.0268988
PloS One; Elkhalii-Wilhelm S, Sippel A et. al.

May 28th, 2022 - Persons with Multiple Sclerosis (pwMS) follow individual strategies to cope with this highly heterogeneous disease. As surveys show, lifestyle habits play an important role in pwMS. However, little is known about individual experiences of pwMS with different lifestyle adjustment strategies. This study aims to describe and understand individual experiences of pwMS with lifestyle adjustments. Sem...

Food safety practice and associated factors in public food establishments of Ethiopia: ...
https://doi.org/10.1371/journal.pone.0268918
PloS One; Tamene A, Habte A et. al.

May 28th, 2022 - In terms of global impact, foodborne infections have been likened to major infectious diseases such as HIV/AIDS, malaria, and tuberculosis, with 1 in 10 people becoming ill and 420,000 deaths per year. A large number of these incidents are caused by improperly handled food in foodservice establishments. Therefore, this systematic review and meta-analysis aims to estimate the proportion of food ...

Ursodeoxycholic acid (UDCA) reduces hepatocyte apoptosis by inhibiting farnesoid X rece...
https://doi.org/10.2174/1566524022666220525152811
Current Molecular Medicine; Wang L, Rui X et. al.

May 28th, 2022 - Hemorrhagic shock (HS) is the most common cause of potentially preventable death after traumatic injury. Acute liver injury is an important manifestation of HS. Apoptosis plays an important role in liver injury. Farnesoid X receptor (FXR) can alleviate liver injury. We designed this experiment to study the effects of ursodeoxycholic acid (UDCA) on hepatocyte apoptosis in HS and its relationship...

Risk of tuberculosis infection and serial changes in interferon-gamma release assays in...
https://doi.org/10.1111/1346-8138.16471
The Journal of Dermatology; Koo T, Baek G et. al.

May 28th, 2022 - Elderly patients constitute a significant proportion of patients with psoriasis. Nonetheless, treatment for older patients is more challenging than that for younger ones. Biologic agents are preferable to other systemic drugs for elderly patients with moderate-to-severe psoriasis owing to their high efficacy and favorable tolerability. However, there are limited data on tuberculosis infection r...

Non-Mutated Nucleophosmin 1 Is Recognized by the CD8+ T Lymphocytes of an AML Patient a...
https://doi.org/10.3390/curroncol29050239
Current Oncology (Toronto, Ont.); Nemeckova S, Alexova-Zurkova K et. al.

May 28th, 2022 - Nucleophosmin (NPM1, B23) is a multifunctional phosphoprotein expressed in all tissues. The protein is mainly localized in nucleoli. In hematological malignancies, NPM1 belongs to commonly altered genes. Its mutation, always heterozygous, leads to the re-localization of the NPM1 protein from the nucleolus to the cytoplasm (NPM1c+). NPM1c+ is found in 30% of acute myeloid leukemia (AML). Our stu...

Immune Checkpoint Inhibitors in Cancer Therapy.
https://doi.org/10.3390/curroncol29050247
Current Oncology (Toronto, Ont.); Shiravand Y, Khodadadi F et. al.

May 28th, 2022 - The discovery of immune checkpoint proteins such as PD-1/PDL-1 and CTLA-4 represents a significant breakthrough in the field of cancer immunotherapy. Therefore, humanized monoclonal antibodies, targeting these immune checkpoint proteins have been utilized successfully in patients with metastatic melanoma, renal cell carcinoma, head and neck cancers and non-small lung cancer. The US FDA has succ...

De-Escalation Strategies for Human Papillomavirus-Associated Oropharyngeal Squamous Cel...
https://doi.org/10.3390/curroncol29050295
Current Oncology (Toronto, Ont.); Silver JA, Turkdogan S et. al.

May 28th, 2022 - The prevalence of oropharyngeal squamous cell carcinoma has been increasing in North America due to human papillomavirus-associated disease. It is molecularly distinct and differs from other head and neck cancers due to the young population and high survival rate. The treatment regimens currently in place cause significant long-term toxicities. Studies have transitioned from mortality-based out...

A Phase 1, Open-Label Study to Evaluate the Effects of Food and Evening Dosing on the P...
https://doi.org/10.1007/s40261-022-01156-4 10.1212/wnl.0000000000007316 10.1098/rsob.170216 10.1038/mp.2018.5 10.1371/journal.pone.0090645 10.1086/345360 10.1203/PDR.0b013e3182242461 10.1111/j.1651-2227.1985.tb10993.x 10.1016/j.jpeds.2009.07.015 10.1016/j.pediatrneurol.2015.06.003 10.1007/s10803-017-3034-3 10.1073/pnas.0812394106 10.1016/j.jns.2008.12.003 10.1016/j.ejps.2017.05.032 10.1007/bf01061694 10.1016/0163-7258(89)90019-3 10.1517/17425255.4.2.175 10.2165/00003088-199937030-00003 10.1016/j.pediatrneurol.2017.07.002 10.1016/j.pediatrneurol.2020.04.019
Clinical Drug Investigation; Darwish M, Youakim JM et. al.

May 28th, 2022 - Trofinetide, a synthetic analog of tripeptide glycine-proline-glutamate, is an investigational agent for the treatment of Rett syndrome, a neurodevelopmental disorder with affected individuals requiring lifelong support. Food can affect the pharmacokinetic profile of a drug, and this phase 1 study assessed the potential effect of food on the pharmacokinetics of trofinetide. The study also evalu...

Corticosteroids for the treatment of Kawasaki disease in children.
https://doi.org/10.1002/14651858.CD011188.pub3
The Cochrane Database of Systematic Reviews; Green J, Wardle AJ et. al.

May 28th, 2022 - Kawasaki disease (KD), or mucocutaneous syndrome, is the leading cause of childhood-acquired heart disease in high-income countries. There is much controversy on how best to treat children with KD and in particular who may benefit from additional treatment beyond the standard intravenous immunoglobulin (IVIG) and aspirin, such as the addition of corticosteroids. This is an update of the review ...