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About 438,353 results

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

PsA: Phase 3 confirms rapid and significant response of secukinumab on synovitis
https://www.mdedge.com/dermatology/article/247831/psoriatic-arthritis/psa-phase-3-confirms-rapid-and-significant-response

Oct 24th, 2021 - Key clinical point: Evaluation with power Doppler ultrasound revealed a rapid and significant reduction of synovitis in patients with psoriatic arthritis (PsA) upon treatment with secukinumab. Major finding : At week 12, the adjusted mean change in the global European League Against Rheumatism (EULAR) and the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) (EULAR-OMERACT) syn.

Anti-TNFα vs thiopurines for the prevention of postoperative recurrence in Crohn's dise...
https://doi.org/10.1016/j.cgh.2021.10.021
Clinical Gastroenterology and Hepatology : the Official C... Beelen EMJ, Nieboer D et. al.

Oct 24th, 2021 - The superiority of anti-TNFα agents to thiopurines for the prevention of postoperative recurrence of Crohn's disease (CD) after ileocolonic resection remains controversial. In this meta-analysis of individual participant data (IPD-MA), the effect of both strategies was compared and assessed after risk stratification. After a systematic literature search, IPD were requested from randomized contr...

Sleep in children and young adults with cystic fibrosis.
https://doi.org/10.1016/j.prrv.2021.09.006
Paediatric Respiratory Reviews; Fauroux B, Waters K et. al.

Oct 24th, 2021 - Large gains have been made in the management of respiratory diseases associated with cystic fibrosis (CF). Initial studies evaluating sleep issues in CF focused on respiratory problems of nocturnal hypoxia, alveolar hypoventilation and risk of airway obstruction from nasal polyps with treatment evaluations including long term oxygen therapy or noninvasive ventilation in case of nocturnal hyperc...

Two-dose COVID-19 vaccination and possible arthritis flare among patients with rheumato...
https://doi.org/10.1136/annrheumdis-2021-221571
Annals of the Rheumatic Diseases; Li X, Tong X et. al.

Oct 24th, 2021 - To investigate the relationship between COVID-19 full vaccination (two completed doses) and possible arthritis flare. Patients with rheumatoid arthritis (RA) were identified from population-based electronic medical records with vaccination linkage and categorised into BNT162b2 (mRNA vaccine), CoronaVac (inactive virus vaccine) and non-vaccinated groups. The risk of possible arthritis flare afte...

SLITRK2, an X-linked modifier of the age at onset in C9orf72 frontotemporal lobar degen...
https://doi.org/10.1093/brain/awab171
Brain : a Journal of Neurology; Barbier M, Camuzat A et. al.

Oct 24th, 2021 - The G4C2-repeat expansion in C9orf72 is the most common cause of frontotemporal dementia and of amyotrophic lateral sclerosis. The variability of age at onset and phenotypic presentations is a hallmark of C9orf72 disease. In this study, we aimed to identify modifying factors of disease onset in C9orf72 carriers using a family-based approach, in pairs of C9orf72 carrier relatives with concordant...

An in vivo Caenorhabditis elegans model for therapeutic research in human prion diseases.
https://doi.org/10.1093/brain/awab152
Brain : a Journal of Neurology; Bizat N, Parrales V et. al.

Oct 24th, 2021 - Human prion diseases are fatal neurodegenerative disorders that include sporadic, infectious and genetic forms. Inherited Creutzfeldt-Jakob disease due to the E200K mutation of the prion protein-coding gene is the most common form of genetic prion disease. The phenotype resembles that of sporadic Creutzfeldt-Jakob disease at both the clinical and pathological levels, with a median disease durat...

Comparison of inhaled mannitol/dornase alfa combination and daily dornase alfa alone in...
https://doi.org/10.1002/ppul.25740
Pediatric Pulmonology; Tural DA, Yalçın E et. al.

Oct 24th, 2021 - Inhaled recombinant human deoxyribonuclease (dornase alfa) and osmotic agents such as inhaled mannitol are used for improving the clearance of secretions of cystic fibrosis (CF) patients. We aimed to evaluate the long term clinical effects of adding dry powder inhaled (DPI) mannitol in subjects with CF who are taking daily dornase alfa. We conducted a retrospective case-control study on subject...

Adjuvant Rituximab - exploratory trial in young people with Graves' disease.
https://doi.org/10.1210/clinem/dgab763
The Journal of Clinical Endocrinology and Metabolism; Cheetham T, Cole M et. al.

Oct 24th, 2021 - Remission rates in young people with Graves' hyperthyroidism are <25% after two years of thionamide antithyroid drug (ATD). We explored whether rituximab, a B lymphocyte depleting agent, would increase remission rates when administered with a short course of ATD. This was an open label multi-centre single arm phase 2 trial in young people (12-20y) with Graves' hyperthyroidism. An A'Hern design ...

The Biology of Synovial Sarcoma: State-of-the-Art and Future Perspectives.
https://doi.org/10.1007/s11864-021-00914-4
Current Treatment Options in Oncology; Fiore M, Sambri A et. al.

Oct 24th, 2021 - New molecular insights are being achieved in synovial sarcoma (SS) that can provide new potential diagnostic and prognostic markers as well as therapeutic targets. In particular, the advancement of research on epigenomics and gene regulation is promising. The concrete hypothesis that the pathogenesis of SS might mainly depend on the disruption of the balance of the complex interaction between e...

Application of comprehensive bioinformatics approaches to reconnoiter crucial genes and...
https://doi.org/10.1007/s12032-021-01576-w 10.1002/hep.31288 10.1016/j.jceh.2014.05.013 10.1097/MOG.0000000000000626 10.1155/2017/5728946 10.1097/MD.0000000000006938 10.1016/j.biopha.2018.11.127 10.1002/hep.21622 10.1016/j.cyto.2015.11.011 10.1016/j.jhep.2012.01.029 10.3390/ijms161023683 10.5001/omj.2020.21 10.1016/j.cyto.2019.02.006 10.1038/sj.bjc.6603061 10.1038/s41467-019-12393-1 10.1186/1476-9255-9-39 10.2147/CMAR.S248539 10.1038/s41417-019-0109-7 10.1158/1078-0432.CCR-14-1936 10.3892/ol.2020.11844 10.1002/jcp.26816 10.1016/j.ecl.2012.04.014 10.4061/2011/523420 10.3390/cancers7010179 10.1038/sj.onc.1210799 10.1002/1098-2264(2000)9999:9999<::AID-GCC1044>3.0.CO;2-N 10.21873/anticanres.13341 10.1186/s12935-019-0956-1 10.1186/s12935-020-01191-1 10.3390/cancers13092232 10.3892/ijmm.2017.3079 10.1016/j.celrep.2017.11.033 10.2174/1568009614666140804154511 10.18632/oncotarget.13760 10.1111/bph.12045 10.1016/j.leukres.2014.06.005
Medical Oncology (Northwood, London, England); Nair G, Hema Sree GNS et. al.

Oct 24th, 2021 - Hepatocellular carcinoma (HCC) is the fifth most common neoplasm in the world. Chronic inflammation of liver and associated wound healing processes collectively contribute to the development of cirrhosis which further progresses to dysplastic nodule and then to HCC. Etiological mediators and ongoing manipulations at cellular level in HCC are well established; however, key protein interactions a...

Reduction of post-operative opioid use in neonates following open congenital diaphragma...
https://doi.org/10.1016/j.jpedsurg.2021.09.027
Journal of Pediatric Surgery; Grabski DF, Vavolizza RD et. al.

Oct 24th, 2021 - A limited number of post-operative opioid reduction strategies have been implemented in the neonatal population. Given the potential neurodevelopment effects of prolonged opioid use, we created a quality improvement initiative to reduce opioids in our NICU and evaluated the intervention in our CDH population. Our opioid reduction intervention was based on standing post-operative IV acetaminophe...

Paediatric tuberculosis preventive treatment preferences among HIV-positive children, c...
https://doi.org/10.1136/bmjopen-2020-048443
BMJ Open; Hirsch-Moverman Y, Strauss M et. al.

Oct 24th, 2021 - Isoniazid preventive therapy initiation and completion rates are suboptimal among children. Shorter tuberculosis (TB) preventive treatment (TPT) regimens have demonstrated safety and efficacy in children and may improve adherence but are not widely used in high TB burden countries. Understanding preferences regarding TPT regimens' characteristics and service delivery models is key to designing ...

Effects of Robot-Assisted Gait Training in Patients with Multiple Sclerosis: A Single-B...
https://doi.org/10.1097/PHM.0000000000001913
American Journal of Physical Medicine & Rehabilitation; Ozsoy-Unubol T, Ata E et. al.

Oct 24th, 2021 - This study aims to evaluate and compare the effects of conventional and robot-assisted gait training (RAGT) programs on fatigue, mood, and quality of life in patients with multiple sclerosis (MS) who have fatigue. In this single-blinded, randomized, controlled study, thirty-seven patients with MS were randomized into two groups: RAGT(n = 18) and conventional gait training (CGT)(n = 19). The RAG...

Relationships between retinopathy of prematurity without ophthalmologic intervention an...
https://doi.org/10.1038/s41390-021-01778-y 10.1016/j.ophtha.2014.07.050 10.1016/j.jaapos.2014.01.014 10.1001/jamaophthalmol.2013.5812 10.1001/jamaophthalmol.2016.0391 10.1001/jama.2013.282153 10.1136/archdischild-2016-312533 10.1542/peds.2018-3537 10.1001/jama.2018.14996 10.1177/0734282906297199 10.1111/j.1469-8749.1997.tb07414.x 10.1016/0029-7844(95)00386-X 10.1016/S0022-3476(78)80282-0 10.1111/aos.13631 10.1212/01.wnl.0000437298.43688.b9 10.1159/000487847 10.1038/sj.jp.7211228 10.1542/peds.106.5.998 10.1111/jnp.12069 10.1542/peds.2017-0257 10.1542/peds.2015-4343 10.1001/archopht.123.3.311
Pediatric Research; Brumbaugh JE, Bell EF et. al.

Oct 24th, 2021 - Severe retinopathy of prematurity (ROP) is associated with adverse outcomes. Relationships between milder ROP and outcomes have not been defined. We hypothesized that children with ROP stage ≤3 who did not receive ophthalmologic intervention would have worse motor, cognitive, and language skills and more vision abnormalities than children without ROP. This was a secondary analysis of a randomiz...

Effect of Cannabidiol on Interictal Epileptiform Activity and Sleep Architecture in Chi...
https://doi.org/10.1007/s40263-021-00867-0 10.1056/NEJMoa1611618 10.1056/NEJMoa1714631 10.1016/S0140-6736(18)30136-3 10.1001/jamaneurol.2020.4607 10.1111/epi.14477 10.3389/fneur.2019.01313 10.1007/s40263-018-0558-9 10.1111/ejn.15096 10.1055/s-0040-1714329 10.1002/epi4.12411 10.1002/acn3.621 10.1016/j.seizure.2016.01.004 10.1093/brain/aww019 10.1016/j.clinph.2016.05.014 10.1016/j.yebeh.2013.06.016 10.1111/epi.13633 10.1016/j.smrv.2021.101472 10.1111/epi.16362 10.1016/S1474-4422(15)00379-8 10.1016/j.yebeh.2017.12.011 10.1016/S1474-4422(08)70018-8 10.1111/epi.12186 10.3389/fneur.2013.00159 10.1111/epi.16823 10.1111/epi.14629 10.1016/j.yebeh.2015.02.043 10.1016/j.yebeh.2020.107558 10.1016/j.jpeds.2004.08.084 10.1016/j.ejpn.2011.04.014 10.1111/epi.16093 10.1053/seiz.2001.0582
CNS Drugs; Klotz KA, Grob D et. al.

Oct 24th, 2021 - Cannabidiol has been shown to be effective in seizure reduction in patients with Dravet syndrome, Lennox-Gastaut syndrome, and tuberous sclerosis. However, very little is known about its potential to reduce interictal epileptiform activity and improve sleep architecture. The objective of this prospective study was to evaluate the influence of cannabidiol therapy on the frequency of interictal e...

COVID-19 vaccine response in people with multiple sclerosis.
https://doi.org/10.1002/ana.26251
Annals of Neurology; Tallantyre EC, Vickaryous N et. al.

Oct 24th, 2021 - To investigate the effect of disease modifying therapies on immune response to SARS-CoV2 vaccines in people with multiple sclerosis. 473 people with multiple sclerosis provided one or more dried blood spot samples. Information about COVID-19 and vaccine history, medical and drug history were extracted from questionnaires and medical records. Dried blood spots were eluted and tested for antibodi...

Identifying a Patient-Centered Outcome Measure for a Comparative Effectiveness Treatmen...
https://doi.org/10.1002/mus.27443
Muscle & Nerve; Narayanaswami P, Sanders DB et. al.

Oct 24th, 2021 - Data regarding the comparative effectiveness of myasthenia gravis (MG) treatments is not available. We used patient input to identify a patient-centered outcome measure (PCOM) for PROMISE-MG, a comparative effectiveness trial of myasthenia gravis (MG) treatments. 1. A questionnaire survey was administered to 58 people with MG at the patient meeting of the Myasthenia Gravis Foundation of America...

Therapeutic antibodies - natural and pathological barriers and strategies to overcome t...
https://doi.org/10.1016/j.pharmthera.2021.108022
Pharmacology & Therapeutics; Al Ojaimi Y, Blin T et. al.

Oct 24th, 2021 - Antibody-based therapeutics have become a major class of therapeutics with over 120 recombinant antibodies approved or under review in the EU or US. This therapeutic class has experienced a remarkable expansion with an expected acceleration in 2021-2022 due to the extraordinary global response to SARS-CoV2 pandemic and the public disclosure of over a hundred anti-SARS-CoV2 antibodies. Mainly de...

Prolonged sub-lethal exposure to galaxolide (HHCB) and tonalide (AHTN) promotes the met...
https://doi.org/10.1016/j.neuro.2021.10.006
Neurotoxicology Doğanlar O, Doğanlar ZB et. al.

Oct 24th, 2021 - Galaxolide and tonalide are well-known polycyclic musks whose intensive use without limitations in numerous cleaning, hygiene, and personal care products has resulted in widespread direct human exposure via absorption, inhalation, and oral ingestion. Latest data shows that long-term, low-dose exposure to toxic chemicals can induce unpredictable harmful effects in a variety of living systems, ho...