×
About 133,390 results

Impact of lenvatinib on renal function compared to sorafenib for unresectable hepatocel...
https://doi.org/10.1097/MD.0000000000029289
Medicine Sasaki R, Fukushima M et. al.

May 19th, 2022 - Anti-VEGF drugs, such as tyrosine kinase inhibitors, play an important role in systemic therapy for unresectable hepatocellular carcinoma (uHCC). We examined the effects of sorafenib and lenvatinib on proteinuria and renal function.Patients who were administered sorafenib (n = 85) or lenvatinib (n = 52) as first line treatment for uHCC from July 2009 to October 2020, were enrolled in this retro...

Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and...
https://doi.org/10.1038/s41467-022-30443-z 10.1038/nn1172 10.1038/nrm1739 10.1093/brain/aws019 10.1016/S1474-4422(14)70040-7 10.3389/fncel.2015.00030 10.1016/j.semcdb.2017.09.031 10.1212/WNL.55.11.1603 10.1148/radiology.182.2.1732969 10.1016/S0896-6273(00)80651-0 10.1093/brain/awl125 10.1111/jnc.14338 10.1038/nn1172 10.1038/nn.2553 10.1038/nature08845 10.1093/cercor/bhq238 10.1523/JNEUROSCI.4773-10.2011 10.1038/nn.2807 10.15252/embr.201642292 10.3389/fncel.2015.00062 10.1038/nn.3729 10.1002/ana.24964 10.1038/s41598-017-15253-4 10.1016/j.celrep.2019.06.096 10.1186/s13041-017-0324-9 10.1523/JNEUROSCI.18-04-01217.1998 10.1016/j.neuron.2018.01.052 10.1038/nmeth0810-575 10.1038/nmeth.3213 10.1038/nmeth.2890 10.1016/j.neuron.2019.06.011 10.1126/science.aad8361 10.1016/S0896-6273(00)80777-1 10.1074/jbc.272.18.11943 10.1016/0896-6273(94)90341-7 10.1016/j.ajhg.2012.04.008 10.1038/35046087 10.1083/jcb.201405060 10.1016/j.neuron.2011.12.030 10.3389/fncel.2014.00215 10.3389/fncel.2015.00099 10.1016/j.conb.2020.10.002 10.1016/0092-8674(95)90370-4 10.1111/ejn.13129 10.1016/j.tcb.2017.10.009 10.1128/MCB.18.10.5838 10.1101/cshperspect.a022442 10.1126/science.1187735 10.1371/journal.pbio.1002440 10.1038/ncb1183 10.1038/nature10163 10.1002/cpmo.48 10.1038/s41467-019-11431-2 10.1016/j.stem.2019.02.017 10.1016/j.tins.2020.07.009 10.1038/ncomms1155 10.1016/j.nbd.2015.08.003 10.1093/nar/gkw971 10.1093/hmg/ddu337 10.1093/cercor/bhn106 10.1523/JNEUROSCI.17-16-06236.1997 10.1242/dev.02330 10.1038/nn1744 10.1016/j.neuron.2006.10.024 10.1016/j.devcel.2017.05.002 10.1016/j.tcb.2017.10.009 10.1101/gad.1178004 10.1016/j.ydbio.2006.12.014 10.1186/s40478-017-0438-4 10.1007/s13760-018-0981-1 10.1016/S0896-6273(00)80809-0 10.1073/pnas.0609628104 10.1091/mbc.e02-11-0747 10.1128/MCB.25.20.8948-8959.2005 10.1038/ncb1673 10.1083/jcb.201002151 10.1242/jcs.051011 10.1371/journal.pbio.3001279 10.1001/jamaneurol.2016.0363 10.1016/j.celrep.2017.11.106 10.1038/ng.3676 10.1038/s41398-018-0327-z 10.1038/nature07287 10.1073/pnas.0610155104 10.1373/clinchem.2008.112797 10.1523/JNEUROSCI.6716-10.2011
Nature Communications; Romero DM, Poirier K et. al.

May 19th, 2022 - Subcortical heterotopias are malformations associated with epilepsy and intellectual disability, characterized by the presence of ectopic neurons in the white matter. Mouse and human heterotopia mutations were identified in the microtubule-binding protein Echinoderm microtubule-associated protein-like 1, EML1. Further exploring pathological mechanisms, we identified a patient with an EML1-like ...

Pulmonary Congestion During Exercise Stress Echocardiography in Ischemic and Heart Fail...
https://doi.org/10.1161/CIRCIMAGING.121.013558
Circulation. Cardiovascular Imaging; Merli E, Ciampi Q et. al.

May 18th, 2022 - Lung ultrasound detects pulmonary congestion as B-lines at rest, and more frequently, during exercise stress echocardiography (ESE). We performed ESE plus lung ultrasound (4-site simplified scan) in 4392 subjects referred for semi-supine bike ESE in 24 certified centers in 9 countries. B-line score ranged from 0 (normal) to 40 (severely abnormal). Five different populations were evaluated: cont...

Tuberculosis: The Disease That Changed World History
https://www.medscape.com/viewarticle/974044

May 16th, 2022 - Almost forgotten today, tuberculosis (TB) is still one of the deadliest infectious diseases in the world. In an interview with Coliquio, Ronald D. Gerste, MD, PhD, an ophthalmologist and historian, looked back on this disease's eventful history, which encompasses outstanding discoveries and catastrophic failures in diagnosis and treatment from the Middle Ages to the present day. Under different...

Exo-erythrocytic development of Plasmodium matutinum (lineage pLINN1) in a naturally in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107739
Malaria Journal; Pendl H, Hernández-Lara C et. al.

May 16th, 2022 - Species of Plasmodium (Haemosporida, Plasmodiidae) are remarkably diverse haemoparasites. Information on genetic diversity of avian malaria pathogens has been accumulating rapidly, however exo-erythrocytic development of these organisms remains insufficiently addressed. This is unfortunate because, contrary to Plasmodium species parasitizing mammals, the avian malaria parasites undergo several ...

Renal Function in Patients with Cystic Fibrosis: A Single-Center Study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105043
International Journal of Environmental Research and Publi... Rachel M, Galiniak S et. al.

May 15th, 2022 - Cystic fibrosis (CF) is the most common incurable autosomal recessive disease affecting the Caucasian population. As the prognosis for life extension of CF patients improves, co-morbidities, including kidney disease, become more common. Identifying those at the highest risk of kidney injury is therefore extremely important. The aim of this study was to evaluate the biomarkers of renal function ...

Vector control in China, from malaria endemic to elimination and challenges ahead.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102289
Infectious Diseases of Poverty; Feng X, Feng J et. al.

May 14th, 2022 - Vector control is an important approach to preventing and controlling malaria. From the malaria epidemic to malaria elimination in China, vector control has played an essential and irreplaceable role in the historical process. This review systematically summarizes the evolution, adjustment, and optimization of vector control strategy towards elimination and discusses the challenges ahead. This ...

Selective plasticity of callosal neurons in the adult contralesional cortex following m...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098892
Nature Communications; Empl L, Chovsepian A et. al.

May 14th, 2022 - Traumatic brain injury (TBI) results in deficits that are often followed by recovery. The contralesional cortex can contribute to this process but how distinct contralesional neurons and circuits respond to injury remains to be determined. To unravel adaptations in the contralesional cortex, we used chronic in vivo two-photon imaging. We observed a general decrease in spine density with concomi...

Emerging Viral Infections and the Potential Impact on Hypertension, Cardiovascular Dise...
https://doi.org/10.1161/CIRCRESAHA.122.320873
Circulation Research; Savedchuk S, Raslan R et. al.

May 14th, 2022 - Viruses are ubiquitous in the environment and continue to have a profound impact on human health and disease. The COVID-19 pandemic has highlighted this with impressive morbidity and mortality affecting the world's population. Importantly, the link between viruses and hypertension, cardiovascular disease, and kidney disease has resulted in a renewed focus and attention on this potential relatio...

A topological data analysis-based method for gait signals with an application to the st...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106173
PloS One; Bois A, Tervil B et. al.

May 14th, 2022 - In the past few years, light, affordable wearable inertial measurement units have been providing to clinicians and researchers the possibility to quantitatively study motor degeneracy by comparing gait trials from patients and/or healthy subjects. To do so, standard gait features can be used but they fail to detect subtle changes in several pathologies including multiple sclerosis. Multiple scl...

CDK4/6 inhibitors sensitize gammaherpesvirus-infected tumor cells to T-cell killing by ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101822
Journal of Translational Medicine; Wu Y, Shrestha P et. al.

May 14th, 2022 - The two oncogenic human gammaherpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), both downregulate immune surface molecules, such as MHC-I, ICAM-1, and B7-2, enabling them to evade T-cell and natural killer cell immunity. Both also either encode for human cyclin homologues or promote cellular cyclin activity, and this has been shown to be important for prol...

Lung response to prone positioning in mechanically-ventilated patients with COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076814
Critical Care (London, England); Protti A, Santini A et. al.

May 8th, 2022 - Prone positioning improves survival in moderate-to-severe acute respiratory distress syndrome (ARDS) unrelated to the novel coronavirus disease (COVID-19). This benefit is probably mediated by a decrease in alveolar collapse and hyperinflation and a more homogeneous distribution of lung aeration, with fewer harms from mechanical ventilation. In this preliminary physiological study we aimed to v...

Do patients with Prader-Willi syndrome have favorable glucose metabolism?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077846
Orphanet Journal of Rare Diseases; Qian Y, Xia F et. al.

May 8th, 2022 - In recent years, more studies have observed that patients with Prader-Willi syndrome have lower insulin levels and lower insulin resistance than body mass index-matched controls, which may suggest protected glucose metabolism. The PubMed and Web of Science online databases were searched to identify relevant studies published in the English language using the terms "Prader-Willi syndrome" with "...

Synaptic Integration in CA1 Pyramidal Neurons Is Intact despite Deficits in GABAergic T...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116933
ENeuro Chancey JH, Howard MA

May 7th, 2022 - Mutations of SCN1A, which encodes the voltage-gated sodium channel Nav1.1, can cause epilepsy disorders such as Dravet syndrome (DS) that are comorbid with wide-ranging neurologic dysfunction. Many studies suggest that Nav1.1 haploinsufficiency causes forebrain GABAergic interneuron hypoexcitability, while pyramidal neuron physiology is mostly unaltered, and that this serves as a primary cell p...

How an Understanding of the Function of the Locus Coeruleus Led to Use of Dexmedetomidi...
https://doi.org/10.1097/PRA.0000000000000634
Journal of Psychiatric Practice; Preskorn SH

May 6th, 2022 - This column reviews >50 years of research on the functions subsumed by the locus coeruleus (LC) (also called the central adrenergic system). A major role of the LC is monitoring acid-base balance in the brain and responding by regulating blood-brain permeability to water and other small molecules and cerebral blood flow. The LC, through its downward projections, also regulates and coordinates r...

Expression of S100A9 and KL-6 in common interstitial lung diseases.
https://doi.org/10.1097/MD.0000000000029198 10.1183/23120541.00019-2016 10.3390/medicina55050161
Medicine Lin L, Zhao Y et. al.

May 6th, 2022 - By evaluating S100 calcium binding protein A9 (S100A9) and Klebs von den Lungen-6 (KL-6) expression in patients with 4 common interstitial lung diseases (ILDs), we aimed to investigate whether S100A9 or KL-6 can be of any value in the differential diagnosis of these ILDs and simultaneously signal the disease progression.We collected the data of patients diagnosed with the 4 ILDs and underwent f...

Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068758
Nature Communications; Ghorbani S, Jelinek E et. al.

May 5th, 2022 - Remyelination failure in multiple sclerosis (MS) contributes to progression of disability. The deficient repair results from neuroinflammation and deposition of inhibitors including chondroitin sulfate proteoglycans (CSPGs). Which CSPG member is repair-inhibitory or alters local inflammation to exacerbate injury is unknown. Here, we correlate high versican-V1 expression in MS lesions with defic...

Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoie...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081225
Nature Neuroscience; Pulous FE, Cruz-Hernández JC et. al.

May 3rd, 2022 - Interactions between the immune and central nervous systems strongly influence brain health. Although the blood-brain barrier restricts this crosstalk, we now know that meningeal gateways through brain border tissues facilitate intersystem communication. Cerebrospinal fluid (CSF), which interfaces with the glymphatic system and thereby drains the brain's interstitial and perivascular spaces, fa...

Hepatorenal Syndrome: Pathophysiology.
https://doi.org/10.1016/j.cld.2022.01.013
Clinics in Liver Disease; Csak T, Bernstein D

Apr 30th, 2022 - Hepatorenal syndrome (HRS) is defined as a functional renal failure without major histologic changes in individuals with severe liver disease and it is associated with a high mortality rate. Renal hypoperfusion due to marked vasoconstriction as a result of complex circulatory dysfunction has been suggested to be the cornerstone of HRS. Splanchnic and peripheral arterial vasodilation and cirrhot...

Polycystic Kidney/Liver Disease.
https://doi.org/10.1016/j.cld.2022.01.009
Clinics in Liver Disease; Roediger R, Dieterich D et. al.

Apr 30th, 2022 - Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder that leads to chronic kidney disease and end-stage kidney disease (ESKD). Polycystic liver disease (PCLD) is the most common extrarenal manifestation of ADPKD. Though isolated PCLD and PCLD due to ADPKD are genetically distinct, they follow a similar clinical course of hepatomegaly from multiple cysts with preserved live...