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About 136,160 results

Cerebrospinal Fluid Hydrodynamics in Chiari I Malformation and Syringomyelia: Modeling ...
https://doi.org/10.1016/j.nec.2022.08.007
Neurosurgery Clinics of North America; Heiss JD

Nov 25th, 2022 - Anatomic MRI, MRI flow studies, and intraoperative ultrasonography demonstrate that the Chiari I malformation obstructs CSF pathways at the foramen magnum and prevents normal CSF movement through the foramen magnum. Impaired CSF displacement across the foramen magnum during the cardiac cycle increases pulsatile hindbrain motion, pressure transmission to the spinal subarachnoid space, and the am...

Mitochondrial protein, TBRG4, modulates KSHV and EBV reactivation from latency.
https://doi.org/10.1371/journal.ppat.1010990
PLoS Pathogens; Zhang H, Wong JP et. al.

Nov 24th, 2022 - Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr (EBV) are gammaherpesviruses associated with multiple human malignancies. KSHV is the etiological agent of Kaposi's Sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). EBV is associated with Burkitt's lymphoma (BL), Hodgkin's lymphoma (HL), nasopharyngeal carcinoma (NPC) and gastric carcinoma (GC). ...

Protrusion of KCNJ13 Gene Knockout Retinal Pigment Epithelium Due to Oxidative Stress-I...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695160
Investigative Ophthalmology & Visual Science; Kanzaki Y, Fujita H et. al.

Nov 23rd, 2022 - This study was performed to elucidate the mechanisms of morphological abnormalities in a Leber congenital amaurosis 16 (LCA16) cell model using KCNJ13 knockout (KO) retinal pigment epithelial cells derived from human iPS cells (hiPSC-RPE). In KCNJ13 KO and wild-type hiPSC-RPE cells, ZO-1 immunofluorescence was performed, and confocal images were captured. The area and perimeter of each cell wer...

OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carci...
https://doi.org/10.1186/s13046-022-02533-9
Journal of Experimental & Clinical Cancer Research : CR; Di M, Miao J et. al.

Nov 22nd, 2022 - Radioresistance is the primary cause of nasopharyngeal carcinoma (NPC) treatment failure. Previous studies have focused on the deficits in cellular apoptosis as a mechanism for radioresistance; however, additional potential death modes involved in modulating radiosensitivity of NPC have not been explored. Pyroptosis was assessed by phase-contrast imaging, LDH release assays, live cell imaging, ...

Examination of Suprahyoid Muscle Resection and Other Factors Affecting Swallowing Funct...
https://doi.org/10.1097/SCS.0000000000008770
The Journal of Craniofacial Surgery; Nakayama Y, Yamakawa N et. al.

Nov 22nd, 2022 - Dysphagia is one of the most common adverse effects associated with oral cancer therapy and could greatly impair postoperative quality of life. The objective of this study was to analyze postoperative swallowing outcomes and factors influencing postoperative swallowing function in patients with advanced oral cancer who underwent primary reconstruction after surgical resection to identify patien...

Huntingtin regulates calcium fluxes in skeletal muscle.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682417
The Journal of General Physiology; Chivet M, McCluskey M et. al.

Nov 22nd, 2022 - The expression of the Huntingtin protein, well known for its involvement in the neurodegenerative Huntington's disease, has been confirmed in skeletal muscle. The impact of HTT deficiency was studied in human skeletal muscle cell lines and in a mouse model with inducible and muscle-specific HTT deletion. Characterization of calcium fluxes in the knock-out cell lines demonstrated a reduction in ...

HEART rate variability biofeedback for long COVID symptoms (HEARTLOC): protocol for a f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680157
BMJ Open; Corrado J, Halpin S et. al.

Nov 22nd, 2022 - Long COVID (LC), also known as post-COVID-19 syndrome, refers to symptoms persisting 12 weeks after COVID-19 infection. It affects up to one in seven people contracting the illness and causes a wide range of symptoms, including fatigue, breathlessness, palpitations, dizziness, pain and brain fog. Many of these symptoms can be linked to dysautonomia or dysregulation of the autonomic nervous syst...

The role of the ZEB1-neuroinflammation axis in CNS disorders.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675144
Journal of Neuroinflammation; Poonaki E, Kahlert UD et. al.

Nov 20th, 2022 - Zinc finger E-box binding homeobox 1 (ZEB1) is a master modulator of the epithelial-mesenchymal transition (EMT), a process whereby epithelial cells undergo a series of molecular changes and express certain characteristics of mesenchymal cells. ZEB1, in association with other EMT transcription factors, promotes neuroinflammation through changes in the production of inflammatory mediators, the m...

Ring stage classification of Babesia microti and Plasmodium falciparum using optical di...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673388
Parasites & Vectors; Mazigo E, Jun H et. al.

Nov 19th, 2022 - Babesia is an intraerythrocytic parasite often misdiagnosed as a malaria parasite, leading to inappropriate treatment of the disease especially in co-endemic areas. In recent years, optical diffraction tomography (ODT) has shown great potential in the field of pathogen detection by quantification of three-dimensional (3D) imaging tomograms. The 3D imaging of biological cells is crucial to inves...

How to choose the surgical side when cerebral blood flow and cerebrovascular response a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666088
Medicine Luo M, Yu J et. al.

Nov 19th, 2022 - Moyamoya disease (MMD) is a rare cerebrovascular disease characterized by progressive occlusion of the internal carotid artery and the secondary formation of collateral vessels. Bypass surgery is an effective treatment for MMD. Comprehensive evaluation of cerebral blood flow (CBF) and cerebrovascular response (CVR) is the common hemodynamic indication to surgery, the changes of which are usuall...

Awareness of postural orthostatic tachycardia syndrome is required in adolescent syncope.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666125
Medicine Kim DH, Park JY et. al.

Nov 19th, 2022 - We investigated head-up tilt test (HUTT) results across age-groups in syncope/presyncope patients to establish pediatric postural orthostatic tachycardia syndrome (POTS) characteristics. We retrospectively reviewed syncope patients' medical records. Adolescents were defined as 10 to 19 years old, adults as 20 to 59 years old, and older individuals as ≥60 years old. From HUTT results, we determi...

Simultaneous Multifrequency (SiMFy) Stimulus: A Novel and Reliable Stimulus for Frequen...
https://doi.org/10.1055/s-0042-1744488
Journal of the American Academy of Audiology; Singh NK, Ravikumar MH et. al.

Nov 19th, 2022 - Frequency tuning of ocular vestibular evoked myogenic potential (oVEMP) refers to the frequency of tone burst that produces the largest amplitude oVEMP. There is an ever-growing pool of published studies that found the frequency tuning of oVEMP distinctly different in Ménière's disease than the age-matched controls and benign paroxysmal positional vertigo. However, recording oVEMP in response t...

Oropharyngeal swallowing physiology and safety in patients with Idiopathic Pulmonary Fi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670476
BMC Pulmonary Medicine; Alamer A, Jones R et. al.

Nov 18th, 2022 - Dysphagia occurs in multiple respiratory pathophysiologies, increasing the risk of pulmonary complications secondary to aspiration. Reflux associated aspiration and a dysregulated lung microbiome is implicated in Idiopathic Pulmonary Fibrosis (IPF), but swallowing dysfunction has not been described. We aimed to explore oropharyngeal swallowing in IPF patients, without known swallowing dysfuncti...

Ascertaining cells' synaptic connections and RNA expression simultaneously with barcode...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668842
Nature Communications; Saunders A, Huang KW et. al.

Nov 18th, 2022 - Brain function depends on synaptic connections between specific neuron types, yet systematic descriptions of synaptic networks and their molecular properties are not readily available. Here, we introduce SBARRO (Synaptic Barcode Analysis by Retrograde Rabies ReadOut), a method that uses single-cell RNA sequencing to reveal directional, monosynaptic relationships based on the paths of a barcoded...

Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669022
Nature Communications; Liu T, Shilliday F et. al.

Nov 18th, 2022 - Plasmodium species cause malaria and kill hundreds of thousands annually. The microtubule-based motor kinesin-8B is required for development of the flagellated Plasmodium male gamete, and its absence completely blocks parasite transmission. To understand the molecular basis of kinesin-8B's essential role, we characterised the in vitro properties of kinesin-8B motor domains from P. berghei and P...

mTOR inhibition attenuates chemosensitivity through the induction of chemotherapy resis...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671908
Nature Communications; Liu Y, Azizian NG et. al.

Nov 18th, 2022 - Chemotherapy can eradicate a majority of cancer cells. However, a small population of tumor cells often survives drug treatments through genetic and/or non-genetic mechanisms, leading to tumor recurrence. Here we report a reversible chemoresistance phenotype regulated by the mTOR pathway. Through a genome-wide CRISPR knockout library screen in pancreatic cancer cells treated with chemotherapeut...

Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhance...
https://doi.org/10.3892/ijo.2022.5454
International Journal of Oncology; Stern L, Boehme LF et. al.

Nov 17th, 2022 - Bitter taste receptors (T2Rs) are G protein‑coupled receptors originally detected in the gustatory system. More recently, T2Rs have been shown to be expressed in extra‑oral cells eliciting non‑gustatory functions. Emerging evidence has suggested a potential role for T2R signaling in diverse pathophysiological conditions, including cancer. -The aim of the present study was to evaluate the expres...

Optic nerve sheath diameter in patients with hepatic encephalopathy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668157
PloS One; Colak N, Bayrak Basakci O et. al.

Nov 17th, 2022 - This study aims to reveal whether the optic nerve sheath diameter (ONSD) increases in hepatic encephalopathy (HE) patients, and to determine ONSD is associated with the poor prognosis of patients with HE. In this retrospective case-control study, HE patients who underwent cranial computerized tomography (CT) were included in the case group; and the patients who underwent CT for other reasons fo...

Interference with LTβR signaling by tick saliva facilitates transmission of Lyme diseas...
https://doi.org/10.1073/pnas.2208274119
Proceedings of the National Academy of Sciences of the Un... Jin L, Jiang BG et. al.

Nov 17th, 2022 - Lyme spirochetes have coevolved with ticks to optimize transmission to hosts using tick salivary molecules (TSMs) to counteract host defenses. TSMs modulate various molecular events at the tick-host interface. Lymphotoxin-beta receptor (LTβR) is a vital immune receptor and plays protective roles in host immunity against microbial infections. We found that Ltbr knockout mice were more susceptibl...

Neuroinflammation regulates the balance between hippocampal neuron death and neurogenes...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664832
Journal of Neuroinflammation; Cassiano LMG, Oliveira MS et. al.

Nov 16th, 2022 - Thiamine (vitamin B1) is a cofactor for enzymes of central energy metabolism and its deficiency (TD) impairs oxidative phosphorylation, increases oxidative stress, and activates inflammatory processes that can lead to neurodegeneration. Wernicke-Korsakoff syndrome (WKS) is a consequence of chronic TD, which leads to extensive neuronal death, and is associated with neuropathological disorders, i...