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About 151,262 results

A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119497
The American Journal of Psychiatry; Phillips ML, Swartz HA

Mar 14th, 2014 - In this critical review, the authors appraise neuroimaging findings in bipolar disorder in emotion-processing, emotion-regulation, and reward-processing neural circuitry in order to synthesize the current knowledge of the neural underpinnings of bipolar disorder and provide a neuroimaging research road map for future studies. The authors examined findings from all major studies in bipolar disor...

Causes of pulmonary hypertension in the elderly.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077408
Chest Pugh ME, Sivarajan L et. al.

Jan 31st, 2014 - Pulmonary hypertension (PH) is common in elderly patients, but a detailed analysis of the causes of PH in the elderly has not been performed. We hypothesized that pulmonary arterial hypertension (PAH) is rare in elderly patients and sought to describe the characteristics of these patients at a large referral center. Clinical and hemodynamic data were collected on consecutive patients ≥ 65 years...

Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review.
https://doi.org/10.1212/WNL.0000000000000815
Neurology Izcovich A, González Malla C et. al.

Aug 25th, 2014 - Symptomatic orthostatic hypotension (SOH) and recurrent reflex syncope (RRS) can be disabling. Midodrine has been proposed in the management of patients with these conditions but its impact on patient important outcomes remains uncertain. We performed a systematic review to evaluate the efficacy and safety of midodrine in patients with SOH and RRS. We searched multiple electronic databases with...

Beneficial effects of growth hormone treatment on cognition in children with Prader-Wil...
https://doi.org/10.1210/jc.2012-1182
The Journal of Clinical Endocrinology and Metabolism; Siemensma EP, Tummers-de Lind van Wijngaarden RF et. al.

Apr 17th, 2012 - Knowledge about the effects of GH treatment on cognitive functioning in children with Prader-Willi syndrome (PWS) is limited. Fifty prepubertal children aged 3.5 to 14 yr were studied in a randomized controlled GH trial during 2 yr, followed by a longitudinal study during 4 yr of GH treatment. Cognitive functioning was measured biennially by short forms of the WPPSI-R or WISC-R, depending on ag...

Adrenocortical carcinoma and pregnancy: clinical and biological features and prognosis.
https://doi.org/10.1530/EJE-10-0412
European Journal of Endocrinology; Abiven-Lepage G, Coste J et. al.

Aug 11th, 2010 - Adrenocortical carcinoma (ACC) is a rare, severe disease. Pregnancy-associated ACC has rarely been reported. We wished to evaluate the characteristics and prognosis of ACC diagnosed in patients during pregnancy or in the postpartum period, comparing them with those for ACC diagnosed in nonpregnant women. Clinical presentation, hormonal secretion, staging, survival, and obstetric data are report...

Tailored approach to the treatment of vernal keratoconjunctivitis.
https://doi.org/10.1016/j.ophtha.2009.11.043
Ophthalmology Sacchetti M, Lambiase A et. al.

Apr 12th, 2010 - To develop a standardized clinical grading system for the management of patients with vernal keratoconjunctivitis (VKC) and to identify the risk factors associated with a worsened outcome of the disease, including decrease of visual acuity and ocular complications development. Retrospective cohort study. A total of 207 consecutive patients with VKC, referred to our Cornea and External Diseases ...

CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia.
https://doi.org/10.1002/ana.21628
Annals of Neurology; Berrih-Aknin S, Ruhlmann N et. al.

Oct 22nd, 2009 - Myasthenia gravis (MG), a neuromuscular disease mediated by anti-acetylcholine receptor (AChR) autoantibodies, is associated with thymic hyperplasia characterized by ectopic germinal centers that contain pathogenic antibody-producing B cells. Our thymic transcriptome study demonstrated increased expression of CCL21, a recruiter of immune cells. Accordingly, we are investigating its implication ...

Aortic calcification: Novel insights from familial hypercholesterolemia and potential r...
https://doi.org/10.1016/j.atherosclerosis.2012.08.026
Atherosclerosis Fantus D, Awan Z et. al.

Oct 8th, 2012 - Once thought to be a passive process of calcium accrual in arterial vascular beds, vascular calcification is considered to be a tightly regulated process mediated by osteoblast-like cells under the dys-regulated interplay of shear stress, metabolites, cytokines and transcription factors. Unfortunately, without effective medical interventions to prevent or regress vascular calcification, this pr...

Finding the fertile woman with phenylketonuria.
https://doi.org/10.1016/j.ejogrb.2007.12.011
European Journal of Obstetrics, Gynecology, and Reproduct... Hanley WB

Feb 11th, 2008 - This review highlights two groups of women with phenylketonuria (PKU) who are at risk of producing offspring with maternal phenylketonuria (MPKU) embryopathy: (I) those not yet diagnosed; (II) those lost to follow-up. The world literature is reviewed, including that published from the International MPKU Collaborative Study (MPKUCS) and evidence is presented to support our hypothesis that at lea...

Cardiac considerations in the operative management of the patient with Duchenne or Beck...
https://doi.org/10.1111/pan.12229
Paediatric Anaesthesia; Cripe LH, Tobias JD

Jul 22nd, 2013 - Duchenne muscular dystrophy/Becker muscular dystrophy (DMD/BMD) is a progressive multisystem neuromuscular disorder. In addition to the skeletal muscle, the myocardium in the DMD/BMD patient is dystrophin deficient which results in a progressive cardiomyopathy. The myopathic myocardium poses significant risk of increased morbidity and mortality at the time of major surgical procedures. Careful ...

Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315021
The Lancet. Neurology; Byrne S, Elamin M et. al.

Feb 6th, 2012 - Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of upper and lower motor neurons, associated with frontotemporal dementia (FTD) in about 14% of incident cases. We assessed the frequency of the recently identified C9orf72 repeat expansion in familial and apparently sporadic cases of ALS and characterised the cognitive and clinical phenotype of patients with this ex...

Prognostic factors and disease course in aquaporin-4 antibody-positive patients with ne...
https://doi.org/10.1093/brain/aws109
Brain : a Journal of Neurology; Kitley J, Leite MI et. al.

May 11th, 2012 - Neuromyelitis optica and neuromyelitis optica spectrum disorders have been recently associated with the disease-specific autoantibody aquaporin-4, thought to be pathogenic. Identifying this antibody has allowed the clinical phenotype to be broadened. It is clear that some patients with similar clinical features do not have this antibody and may have a different condition with different outcomes...

Differential regulation of interleukin 12 and interleukin 23 production in human dendri...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413040
The Journal of Experimental Medicine; Gerosa F, Baldani-Guerra B et. al.

May 20th, 2008 - We analyzed interleukin (IL) 12 and IL-23 production by monocyte-derived dendritic cells (mono-DCs). Mycobacterium tuberculosis H37Rv and zymosan preferentially induced IL-23. IL-23 but not IL-12 was efficiently induced by the combination of nucleotide-binding oligodimerization domain and Toll-like receptor (TLR) 2 ligands, which mimics activation by M. tuberculosis, or by the human dectin-1 li...

Early clinical markers of central nervous system involvement in mucopolysaccharidosis t...
https://doi.org/10.1016/j.jpeds.2011.03.019
The Journal of Pediatrics; Holt J, Poe MD et. al.

May 2nd, 2011 - To identify early clinical markers of neurologic involvement in mucopolysaccharidosis type II. A retrospective review of neurobehavioral standardized assessments of patients with mucopolysaccharidosis type II evaluated at the Program for Neurodevelopmental Function in Rare Disorders was completed. Patients were grouped based on the presence or absence of central nervous system (CNS) involvement...

Is a wake-up call in order? Review of the evidence for awake craniotomy.
https://doi.org/10.1016/j.jocn.2015.11.004
Journal of Clinical Neuroscience : Official Journal of Th... Paldor I, Drummond KJ et. al.

Dec 17th, 2015 - Awake craniotomy (AC) has been used in increasing frequency in the past few decades. It has mainly been used for resection of intrinsic tumors, but also, rarely, for other pathologies. The vast majority of reports specific to one pathology, however, have focused on resection of low grade glioma in the awake setting. Tumors in eloquent areas have mainly been resected when the patient is awake fo...

Phenotyping adults with non-cystic fibrosis bronchiectasis: a prospective observational...
https://doi.org/10.1016/j.rmed.2013.04.013
Respiratory Medicine; Anwar GA, McDonnell MJ et. al.

May 15th, 2013 - Bronchiectasis is the outcome of a number of different airway insults. Very few studies have characterised the aetiology and utility of a dedicated screening proforma in adult patients attending a general bronchiectasis clinic. A prospective observational study of 189 bronchiectasis patients attending two centres in the North East of England over a two-year period was performed. The aetiology o...

Pheochromocytomas: the (pseudo)-hypoxia hypothesis.
https://doi.org/10.1016/j.beem.2010.10.004
Best Practice & Research. Clinical Endocrinology & Metabo... Favier J, Gimenez-Roqueplo AP

Nov 30th, 2010 - Hypoxia and pheochromocytoma/paraganglioma have a long common history. Since the description, almost 40 years ago, of an increased incidence of head and neck paragangliomas in chronic hypoxia, discoveries on oxygen-sensing and on hereditary paraganglioma in the beginning of years 2000 provided the proof of concept of a strong link between these neuroendocrine tumors and the hypoxic pathway. It ...

Efficacy of 3,4-diaminopyridine and pyridostigmine in the treatment of Lambert-Eaton my...
https://doi.org/10.1038/clpt.2009.35
Clinical Pharmacology and Therapeutics; Wirtz PW, Verschuuren JJ et. al.

Apr 9th, 2009 - 3,4-Diaminopyridine and pyridostigmine are widely used to treat Lambert-Eaton myasthenic syndrome (LEMS), either alone or in combination. 3,4-Diaminopyridine enhances the release of acetylcholine at the neuromuscular synapse, and pyridostigmine inhibits the degradation of this neurotransmitter. Although this could lead to a synergistic effect on neuromuscular transmission, no studies have compa...

Inclusion body myositis: review of recent literature.
https://www.ncbi.nlm.nih.gov/pubmed/19080758
Current Neurology and Neuroscience Reports; Greenberg SA

Dec 16th, 2008 - Inclusion body myositis (IBM) is a progressive inflammatory skeletal muscle disease of unknown cause and without effective treatment. This article discusses existing literature, emphasizing disease mechanisms and models. In particular, it addresses limitations in the beta-amyloid-mediated theory of IBM myofiber injury, flawed rationales of animal models of this disease, and recent reports regar...

Short-term exercise training improves the cardiovascular response to exercise in the po...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547265
The Journal of Physiology; Shibata S, Fu Q et. al.

May 29th, 2012 - Recent studies have suggested the presence of cardiac atrophy as a key component of the pathogenesis of the postural orthostatic tachycardia syndrome (POTS), similar to physical deconditioning. It has also been shown that exercise intolerance is associated with a reduced stroke volume (SV) in POTS, and that the high heart rate (HR) observed at rest and during exercise in these patients is due t...