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About 123,595 results

Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504098
Clinical Epigenetics; Saiz ML, De Diego ML et. al.

Oct 13th, 2021 - SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) and neuropilin-1 (NRP1) receptors for entry into cells, and the serine protease TMPRSS2 for S protein priming. Inhibition of protease activity or the engagement with ACE2 and NRP1 receptors has been shown to be an effective strategy for blocking infectivity and viral spreading. Valproic acid (VPA; 2-propylpentanoic acid) is an epigeneti...

CircCDC45 promotes the malignant progression of glioblastoma by modulating the miR-485-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501713
BMC Cancer; Liu R, Dai W et. al.

Oct 11th, 2021 - Glioblastoma (GBM) is characterized by progressive growth and metastasis. Numerous studies claim that the deregulation of circular RNAs (circRNAs) is associated with cancer progression. However, the role of circRNAs in GBM is largely limited. The purpose of this study was to investigate the functions of circCDC45 in GBM and provide a feasible functional mechanism to support its role. The expres...

Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minire...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492288
Mediators of Inflammation; Vyavahare S, Kumar S et. al.

Oct 9th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs. Several studies have reported that the tryptophan-kynurenine pathway is altered in COVID-19 patients. The tryptophan-kynurenine pathway plays a vital role in regulating inflammation, metabolism, immune responses, an...

Evaluation of Respiratory Emissions During Labor and Delivery: Potential Implications f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462302
Obstetrics and Gynecology; Mok T, Harris E et. al.

Oct 9th, 2021 - To characterize respiratory emissions produced during labor and vaginal delivery vis-à-vis the potential for transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Observational study of three women who tested negative for SARS-CoV-2 and had uncomplicated vaginal deliveries. Using background-oriented schlieren imaging, we evaluated the propagation of respiratory emissions...

COVID-19 in pregnancy: placental pathological patterns and effect on perinatal outcome ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487453
Diagnostic Pathology; Giordano G, Petrolini C et. al.

Oct 5th, 2021 - COVID-19, the disease caused by the novel coronavirus SARS-CoV-2, is a severe systemic thrombotic syndrome that emerged in 2019, with an ensuing pandemic. To evaluate the impact of this disease on placental tissue and perinatal outcome, histological, immunohistochemical and ultrastructural analyses of placental tissue were performed for five cases of pregnant women with COVID-19. All five pregn...

Effect of ORF7 of SARS-CoV-2 on the Chemotaxis of Monocytes and Neutrophils In Vitro.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483903
Disease Markers; Wang G, Guan J et. al.

Oct 5th, 2021 - Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the most significant public health threat worldwide. Patients with severe COVID-19 usually have pneumonia concomitant with local inflammation and sometimes a cytokine storm. Specific components of the SARS-CoV-2 virus trigger lung inflammation, and recruitment of immune ce...

Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486878
Nature Communications; Thery F, Martina L et. al.

Oct 3rd, 2021 - ISG15 is an interferon-stimulated, ubiquitin-like protein that can conjugate to substrate proteins (ISGylation) to counteract microbial infection, but the underlying mechanisms remain elusive. Here, we use a virus-like particle trapping technology to identify ISG15-binding proteins and discover Ring Finger Protein 213 (RNF213) as an ISG15 interactor and cellular sensor of ISGylated proteins. RN...

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513853
PLoS Pathogens; Meyers JM, Ramanathan M et. al.

Oct 2nd, 2021 - Viral proteins localize within subcellular compartments to subvert host machinery and promote pathogenesis. To study SARS-CoV-2 biology, we generated an atlas of 2422 human proteins vicinal to 17 SARS-CoV-2 viral proteins using proximity proteomics. This identified viral proteins at specific intracellular locations, such as association of accessary proteins with intracellular membranes, and pro...

The efficacy of insecticide-treated window screens and eaves against Anopheles mosquito...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480128
Malaria Journal; Anaele BI, Varshney K et. al.

Oct 1st, 2021 - Female mosquitoes serve as vectors for a host of illnesses, including malaria, spread by the Plasmodium parasite. Despite monumental strides to reduce this disease burden through tools such as bed nets, the rate of these gains is slowing. Ongoing disruptions related to the COVID-19 pandemic may also negatively impact gains. The following scoping review was conducted to examine novel means of re...

Factors affecting duration of SARS-Cov-2 viral shedding in mildly symptomatic patients ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476038
PloS One; Cheng HM, Zhao X et. al.

Sep 28th, 2021 - Mildly symptomatic cases of Covid-19 in previously-well individuals form the majority of infections and also serve as potent vectors of transmission. The factors affecting the duration of SARS-CoV-2 RNA viral shedding (DVS) in these patients remain largely unknown. To perform a systematic analysis of the clinical, radiologic, laboratory investigations in patients with few comorbidities infected...

Bacterial and fungal growth in sputum cultures from 165 COVID-19 pneumonia patients req...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465781
Annals of Clinical Microbiology and Antimicrobials; Liu HH, Yaron D et. al.

Sep 27th, 2021 - Coronavirus SARS-CoV-2 causes COVID-19 illness which can progress to severe pneumonia. Empiric antibacterials are often employed though frequency of bacterial coinfection superinfection is debated and concerns raised about selection of bacterial antimicrobial resistance. We evaluated sputum bacterial and fungal growth from 165 intubated COVID-19 pneumonia patients. Objectives were to determine ...

COVID-19 pandemic restrictions continuously impact on physical activity in adults with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460042
PloS One; Radtke T, Haile SR et. al.

Sep 24th, 2021 - We have recently reported reduced physical activity (PA) in people with cystic fibrosis (pwCF) with and without lung transplantation (LTX) during a 6-week stringent lockdown in Switzerland. This follow-up study explores the impact of coronavirus-2019 disease (COVID-19) related pandemic restrictions on individuals' therapy regimens and health-related aspects in pwCF. We conducted a cross-section...

The Clp1 R140H mutation alters tRNA metabolism and mRNA 3' processing in mouse models o...
https://doi.org/10.1073/pnas.2110730118
Proceedings of the National Academy of Sciences of the Un... Monaghan CE, Adamson SI et. al.

Sep 23rd, 2021 - Homozygous mutation of the RNA kinase CLP1 (cleavage factor polyribonucleotide kinase subunit 1) causes pontocerebellar hypoplasia type 10 (PCH10), a pediatric neurodegenerative disease. CLP1 is associated with the transfer RNA (tRNA) splicing endonuclease complex and the cleavage and polyadenylation machinery, but its function remains unclear. We generated two mouse models of PCH10: one homozy...

Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.
https://doi.org/10.1073/pnas.2101268118
Proceedings of the National Academy of Sciences of the Un... Wang J, Filippakis H et. al.

Sep 22nd, 2021 - Tuberous sclerosis complex (TSC) and lymphangioleiomyomatosis (LAM) are caused by aberrant mechanistic Target of Rapamycin Complex 1 (mTORC1) activation due to loss of either TSC1 or TSC2 Cytokine profiling of TSC2-deficient LAM patient-derived cells revealed striking up-regulation of Interleukin-6 (IL-6). LAM patient plasma contained increased circulating IL-6 compared with healthy controls, a...

Altered gut microbial metabolites could mediate the effects of risk factors in Covid-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995004
Reviews in Medical Virology; Chen J, Hall S et. al.

Sep 22nd, 2021 - Coronavirus disease 2019 (Covid-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is now pandemic. While most Covid-19 patients will experience mild symptoms, a small proportion will develop severe disease, which could be fatal. Clinically, Covid-19 patients manifest fever with dry cough, fatigue and dyspnoea, and in severe cases develop into acute respirato...

How strong is the evidence that it is possible to get SARS-CoV-2 twice? A systematic re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883277
Reviews in Medical Virology; Farrukh L, Mumtaz A et. al.

Sep 22nd, 2021 - With a large number of coronavirus disease 2019 (Covid-19) patients being discharged from hospital with negative test results for SARS-CoV-2, it has been reported that several recovered cases tested positive after discharge (re-positive, RP). This finding has raised several important questions for this novel coronavirus and Covid-19 disease. In this review, we have discussed several important q...

Lipid-based therapies against SARS-CoV-2 infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013851
Reviews in Medical Virology; Alketbi EH, Hamdy R et. al.

Sep 22nd, 2021 - Viruses have evolved to manipulate host lipid metabolism to benefit their replication cycle. Enveloped viruses, including coronaviruses, use host lipids in various stages of the viral life cycle, particularly in the formation of replication compartments and envelopes. Host lipids are utilised by the virus in receptor binding, viral fusion and entry, as well as viral replication. Association of ...

Norrie disease protein is essential for cochlear hair cell maturation.
https://doi.org/10.1073/pnas.2106369118
Proceedings of the National Academy of Sciences of the Un... Hayashi Y, Chiang H et. al.

Sep 22nd, 2021 - Mutations in the gene for Norrie disease protein (Ndp) cause syndromic deafness and blindness. We show here that cochlear function in an Ndp knockout mouse deteriorated with age: At P3-P4, hair cells (HCs) showed progressive loss of Pou4f3 and Gfi1, key transcription factors for HC maturation, and Myo7a, a specialized myosin required for normal function of HC stereocilia. Loss of expression of ...

Multi-level inhibition of coronavirus replication by chemical ER stress.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452654
Nature Communications; Shaban MS, Müller C et. al.

Sep 22nd, 2021 - Coronaviruses (CoVs) are important human pathogens for which no specific treatment is available. Here, we provide evidence that pharmacological reprogramming of ER stress pathways can be exploited to suppress CoV replication. The ER stress inducer thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types including primary differentiated ...

In brief: A shorter treatment regimen for tuberculosis.
https://www.ncbi.nlm.nih.gov/pubmed/34544105
The Medical Letter on Drugs and Therapeutics;

Sep 21st, 2021 - In brief: A shorter treatment regimen for tuberculosis.|2021||administration & dosage,administration & dosage,drug effects,physiology,methods,diagnosis,drug therapy,epidemiology,