https://doi.org/10.1097/MD.0000000000029289
Medicine Sasaki R, Fukushima M et. al.
May 19th, 2022 - Anti-VEGF drugs, such as tyrosine kinase inhibitors, play an important role in systemic therapy for unresectable hepatocellular carcinoma (uHCC). We examined the effects of sorafenib and lenvatinib on proteinuria and renal function.Patients who were administered sorafenib (n = 85) or lenvatinib (n = 52) as first line treatment for uHCC from July 2009 to October 2020, were enrolled in this retro...
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Nature Communications; Romero DM, Poirier K et. al.
May 19th, 2022 - Subcortical heterotopias are malformations associated with epilepsy and intellectual disability, characterized by the presence of ectopic neurons in the white matter. Mouse and human heterotopia mutations were identified in the microtubule-binding protein Echinoderm microtubule-associated protein-like 1, EML1. Further exploring pathological mechanisms, we identified a patient with an EML1-like ...
https://doi.org/10.1161/CIRCIMAGING.121.013558
Circulation. Cardiovascular Imaging; Merli E, Ciampi Q et. al.
May 18th, 2022 - Lung ultrasound detects pulmonary congestion as B-lines at rest, and more frequently, during exercise stress echocardiography (ESE). We performed ESE plus lung ultrasound (4-site simplified scan) in 4392 subjects referred for semi-supine bike ESE in 24 certified centers in 9 countries. B-line score ranged from 0 (normal) to 40 (severely abnormal). Five different populations were evaluated: cont...
https://www.medscape.com/viewarticle/974044
May 16th, 2022 - Almost forgotten today, tuberculosis (TB) is still one of the deadliest infectious diseases in the world. In an interview with Coliquio, Ronald D. Gerste, MD, PhD, an ophthalmologist and historian, looked back on this disease's eventful history, which encompasses outstanding discoveries and catastrophic failures in diagnosis and treatment from the Middle Ages to the present day. Under different...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107739
Malaria Journal; Pendl H, Hernández-Lara C et. al.
May 16th, 2022 - Species of Plasmodium (Haemosporida, Plasmodiidae) are remarkably diverse haemoparasites. Information on genetic diversity of avian malaria pathogens has been accumulating rapidly, however exo-erythrocytic development of these organisms remains insufficiently addressed. This is unfortunate because, contrary to Plasmodium species parasitizing mammals, the avian malaria parasites undergo several ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105043
International Journal of Environmental Research and Publi... Rachel M, Galiniak S et. al.
May 15th, 2022 - Cystic fibrosis (CF) is the most common incurable autosomal recessive disease affecting the Caucasian population. As the prognosis for life extension of CF patients improves, co-morbidities, including kidney disease, become more common. Identifying those at the highest risk of kidney injury is therefore extremely important. The aim of this study was to evaluate the biomarkers of renal function ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102289
Infectious Diseases of Poverty; Feng X, Feng J et. al.
May 14th, 2022 - Vector control is an important approach to preventing and controlling malaria. From the malaria epidemic to malaria elimination in China, vector control has played an essential and irreplaceable role in the historical process. This review systematically summarizes the evolution, adjustment, and optimization of vector control strategy towards elimination and discusses the challenges ahead. This ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098892
Nature Communications; Empl L, Chovsepian A et. al.
May 14th, 2022 - Traumatic brain injury (TBI) results in deficits that are often followed by recovery. The contralesional cortex can contribute to this process but how distinct contralesional neurons and circuits respond to injury remains to be determined. To unravel adaptations in the contralesional cortex, we used chronic in vivo two-photon imaging. We observed a general decrease in spine density with concomi...
https://doi.org/10.1161/CIRCRESAHA.122.320873
Circulation Research; Savedchuk S, Raslan R et. al.
May 14th, 2022 - Viruses are ubiquitous in the environment and continue to have a profound impact on human health and disease. The COVID-19 pandemic has highlighted this with impressive morbidity and mortality affecting the world's population. Importantly, the link between viruses and hypertension, cardiovascular disease, and kidney disease has resulted in a renewed focus and attention on this potential relatio...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106173
PloS One; Bois A, Tervil B et. al.
May 14th, 2022 - In the past few years, light, affordable wearable inertial measurement units have been providing to clinicians and researchers the possibility to quantitatively study motor degeneracy by comparing gait trials from patients and/or healthy subjects. To do so, standard gait features can be used but they fail to detect subtle changes in several pathologies including multiple sclerosis. Multiple scl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101822
Journal of Translational Medicine; Wu Y, Shrestha P et. al.
May 14th, 2022 - The two oncogenic human gammaherpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), both downregulate immune surface molecules, such as MHC-I, ICAM-1, and B7-2, enabling them to evade T-cell and natural killer cell immunity. Both also either encode for human cyclin homologues or promote cellular cyclin activity, and this has been shown to be important for prol...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076814
Critical Care (London, England); Protti A, Santini A et. al.
May 8th, 2022 - Prone positioning improves survival in moderate-to-severe acute respiratory distress syndrome (ARDS) unrelated to the novel coronavirus disease (COVID-19). This benefit is probably mediated by a decrease in alveolar collapse and hyperinflation and a more homogeneous distribution of lung aeration, with fewer harms from mechanical ventilation. In this preliminary physiological study we aimed to v...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077846
Orphanet Journal of Rare Diseases; Qian Y, Xia F et. al.
May 8th, 2022 - In recent years, more studies have observed that patients with Prader-Willi syndrome have lower insulin levels and lower insulin resistance than body mass index-matched controls, which may suggest protected glucose metabolism. The PubMed and Web of Science online databases were searched to identify relevant studies published in the English language using the terms "Prader-Willi syndrome" with "...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116933
ENeuro Chancey JH, Howard MA
May 7th, 2022 - Mutations of SCN1A, which encodes the voltage-gated sodium channel Nav1.1, can cause epilepsy disorders such as Dravet syndrome (DS) that are comorbid with wide-ranging neurologic dysfunction. Many studies suggest that Nav1.1 haploinsufficiency causes forebrain GABAergic interneuron hypoexcitability, while pyramidal neuron physiology is mostly unaltered, and that this serves as a primary cell p...
https://doi.org/10.1097/PRA.0000000000000634
Journal of Psychiatric Practice; Preskorn SH
May 6th, 2022 - This column reviews >50 years of research on the functions subsumed by the locus coeruleus (LC) (also called the central adrenergic system). A major role of the LC is monitoring acid-base balance in the brain and responding by regulating blood-brain permeability to water and other small molecules and cerebral blood flow. The LC, through its downward projections, also regulates and coordinates r...
https://doi.org/10.1097/MD.0000000000029198 10.1183/23120541.00019-2016 10.3390/medicina55050161
Medicine Lin L, Zhao Y et. al.
May 6th, 2022 - By evaluating S100 calcium binding protein A9 (S100A9) and Klebs von den Lungen-6 (KL-6) expression in patients with 4 common interstitial lung diseases (ILDs), we aimed to investigate whether S100A9 or KL-6 can be of any value in the differential diagnosis of these ILDs and simultaneously signal the disease progression.We collected the data of patients diagnosed with the 4 ILDs and underwent f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068758
Nature Communications; Ghorbani S, Jelinek E et. al.
May 5th, 2022 - Remyelination failure in multiple sclerosis (MS) contributes to progression of disability. The deficient repair results from neuroinflammation and deposition of inhibitors including chondroitin sulfate proteoglycans (CSPGs). Which CSPG member is repair-inhibitory or alters local inflammation to exacerbate injury is unknown. Here, we correlate high versican-V1 expression in MS lesions with defic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081225
Nature Neuroscience; Pulous FE, Cruz-Hernández JC et. al.
May 3rd, 2022 - Interactions between the immune and central nervous systems strongly influence brain health. Although the blood-brain barrier restricts this crosstalk, we now know that meningeal gateways through brain border tissues facilitate intersystem communication. Cerebrospinal fluid (CSF), which interfaces with the glymphatic system and thereby drains the brain's interstitial and perivascular spaces, fa...
https://doi.org/10.1016/j.cld.2022.01.013
Clinics in Liver Disease; Csak T, Bernstein D
Apr 30th, 2022 - Hepatorenal syndrome (HRS) is defined as a functional renal failure without major histologic changes in individuals with severe liver disease and it is associated with a high mortality rate. Renal hypoperfusion due to marked vasoconstriction as a result of complex circulatory dysfunction has been suggested to be the cornerstone of HRS. Splanchnic and peripheral arterial vasodilation and cirrhot...
https://doi.org/10.1016/j.cld.2022.01.009
Clinics in Liver Disease; Roediger R, Dieterich D et. al.
Apr 30th, 2022 - Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder that leads to chronic kidney disease and end-stage kidney disease (ESKD). Polycystic liver disease (PCLD) is the most common extrarenal manifestation of ADPKD. Though isolated PCLD and PCLD due to ADPKD are genetically distinct, they follow a similar clinical course of hepatomegaly from multiple cysts with preserved live...
