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About 132,243 results

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
https://doi.org/10.1002/art.41752
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

Subannular repair for functional mitral regurgitation with reduced systolic ventricle f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801540
Journal of Cardiothoracic Surgery; Girdauskas E, Pausch J et. al.

Dec 30th, 2022 - Functional mitral regurgitation (FMR) is one of the most common heart valve diseases that is a sequel of left ventricular remodelling. Although mitral valve annuloplasty is a standard treatment of FMR, the recurrence of FMR is a major drawback and occurs in 10-50% of patients. The REFORM-MR registry aims to investigate the effectiveness of standardized papillary muscle relocation and ring annul...

Assessing the health risk of living near composting facilities on lung health, fungal a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753251
Environmental Health : a Global Access Science Source; Khan MS, Douglas P et. al.

Dec 15th, 2022 - To explore the health risk of living near permitted composting sites (PCSs) on disease severity in children and adults with cystic fibrosis (CF) across the UK.  METHODS: A semi-individual cross-sectional study was used to examine the risk of disease severity in people with CF (pwCF) within and beyond 4 km of PCSs in the UK in 2016. All pwCF registered in the UK CF Registry were eligible for thi...

Defective synaptic plasticity in a model of Coffin-Lowry syndrome is rescued by simulta...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749851
Learning & Memory (Cold Spring Harbor, N.Y.); Liu RY, Zhang Y et. al.

Nov 30th, 2022 - Empirical and computational methods were combined to examine whether individual or dual-drug treatments can restore the deficit in long-term synaptic facilitation (LTF) of the Aplysia sensorimotor synapse observed in a cellular model of Coffin-Lowry syndrome (CLS). The model was produced by pharmacological inhibition of p90 ribosomal S6 kinase (RSK) activity. In this model, coapplication of an ...

COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703393
Current Cardiology Reports; Furqan M, Chawla S et. al.

Nov 29th, 2022 - To review myocarditis and pericarditis developing after COVID-19 vaccinations and identify the management strategies. COVID-19 mRNA vaccines are safe and effective. Systemic side effects of the vaccines are usually mild and transient. The incidence of acute myocarditis/pericarditis following COVID-19 vaccination is extremely low and ranges 2-20 per 100,000. The absolute number of myocarditis ev...

Prediction and assessment of acute encephalopathy syndromes immediately after febrile s...
https://doi.org/10.1016/j.braindev.2022.10.004
Brain & Development; Uematsu K, Matsumoto H et. al.

Nov 4th, 2022 - This study aimed to predict occurrence of acute encephalopathy syndromes (AES) immediately after febrile status epilepticus in children and to explore the usefulness of electroencephalogram (EEG) in the early diagnosis of AES. We reviewed data from 120 children who had febrile status epilepticus lasting >30 min and were admitted to our hospital between 2012 and 2019. AES with reduced diffusion ...

Inflammation fuels bone marrow exhaustion caused by Samd9l mutation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621124
The Journal of Clinical Investigation; Jung M

Nov 2nd, 2022 - Sterile α motif domain-containing 9 (SAMD9) and SAMD9-like (SAMD9L) syndromes are inherited bone marrow failure syndromes known for their frequent development of myelodysplastic syndrome with monosomy 7. In this issue of the JCI, Abdelhamed, Thomas, et al. report a mouse model with a hematopoietic cell-specific heterozygous Samd9l mutation knockin. This mouse model resembles human disease in ma...

In children with primary ciliary dyskinesia, which type of lung function test is the ea...
https://doi.org/10.1002/ppul.26213
Pediatric Pulmonology; Zafar A, Hall M

Oct 22nd, 2022 - Primary ciliary dyskinesia is a rare genetic disorder characterized by recurrent sinopulmonary infections and worsening obstructive lung disease. Kidney and brain involvement is less common and is associated with overlapping ciliopathies/syndromes. The lungs are impacted early in the course of the disease, so it is vital to monitor lung function and recognize any decline by doing appropriate lu...

Implications of Neural Plasticity in Retinal Prosthesis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586139
Investigative Ophthalmology & Visual Science; Caravaca-Rodriguez D, Gaytan SP et. al.

Oct 18th, 2022 - Retinal degenerative diseases such as retinitis pigmentosa cause a progressive loss of photoreceptors that eventually prevents the affected person from perceiving visual sensations. The absence of a visual input produces a neural rewiring cascade that propagates along the visual system. This remodeling occurs first within the retina. Then, subsequent neuroplastic changes take place at higher vi...

Post-viral fatigue in COVID-19: A review of symptom assessment methods, mental, cogniti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528075
Neuroscience and Biobehavioral Reviews; Campos MC, Nery T et. al.

Oct 7th, 2022 - Coronavirus 2 is responsible for Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), and the main sequela is persistent fatigue. Post-viral fatigue is common and affects patients with mild, asymptomatic coronavirus disease-2019 (COVID-19). However, the exact mechanisms involved in developing post-COVID-19 fatigue remain unclear. Furthermore, physical and cognitive impairments in these...

Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.
https://doi.org/10.1002/jbmr.4714
Journal of Bone and Mineral Research : the Official Journ... Pasieka JL, Wentworth K et. al.

Sep 26th, 2022 - The approach utilized a systematic review of the medical literature executed with specifically designed criteria that focused on the etiologies and pathogenesis of hypoparathyroidism. Enhanced attention by endocrine surgeons to new knowledge about parathyroid gland viability are reviewed along with the role of intraoperative parathyroid hormone (ioPTH) monitoring during and after neck surgery. ...

Sexual function and fertility of adult males with anorectal malformations or Hirschspru...
https://doi.org/10.1007/s00383-022-05216-w
Pediatric Surgery International; Reppucci ML, Wehrli LA et. al.

Sep 24th, 2022 - The long-term impact of anorectal malformations (ARM) and Hirschsprung disease (HD) on sexual function is well recognized but understudied. This study evaluated self-reported sexual and fertility outcomes in adult males with ARM and HD. This was an IRB approved, prospective study of males in the Adult Colorectal Research Registry who completed surveys between October 2019 and March 2022. Electr...

A TRPM7 mutation linked to familial trigeminal neuralgia: Omega current and hyperexcita...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499596
Proceedings of the National Academy of Sciences of the Un... Gualdani R, Gailly P et. al.

Sep 13th, 2022 - Trigeminal neuralgia (TN) is a unique pain disorder characterized by intense paroxysmal facial pain within areas innervated by the trigeminal nerve. Although most cases of TN are sporadic, familial clusters of TN suggest that genetic factors may contribute to this disorder. Whole-exome sequencing in patients with TN reporting positive family history demonstrated a spectrum of variants of ion ch...

Associations between urate levels and amyotrophic lateral sclerosis functional score wi...
https://doi.org/10.1002/mus.27699
Muscle & Nerve; Takahashi F, Kano O et. al.

Sep 3rd, 2022 - Edaravone in amyotrophic lateral sclerosis (ALS) was analyzed in two phase 3 studies (MCI186-16 and MCI186-19). Those trials enrolled patients with Japanese ALS severity grades 1 and 2 (less severe ALS), but many patients progressed to grades 3 and 4 during the double-blind treatment period. The placebo patients who initiated edaravone treatment in the open-label periods provided an opportunity...

Dysregulated naive B cells and de novo autoreactivity in severe COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630115
Nature Woodruff MC, Ramonell RP et. al.

Sep 1st, 2022 - Severe SARS-CoV-2 infection1 has been associated with highly inflammatory immune activation since the earliest days of the COVID-19 pandemic2-5. More recently, these responses have been associated with the emergence of self-reactive antibodies with pathologic potential6-10, although their origins and resolution have remained unclear11. Previously, we and others have identified extrafollicular B...

Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436336
Proceedings of the National Academy of Sciences of the Un... Scherer M, Steiner LA et. al.

Aug 27th, 2022 - Deep brain stimulation procedures offer an invaluable opportunity to study disease through intracranial recordings from awake patients. Here, we address the relationship between single-neuron and aggregate-level (local field potential; LFP) activities in the subthalamic nucleus (STN) and thalamic ventral intermediate nucleus (Vim) of patients with Parkinson's disease (n = 19) and essential trem...

A case of Miller Fisher syndrome with delayed onset peripheral facial nerve palsy after...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395791
BMC Neurology; Nanatsue K, Takahashi M et. al.

Aug 23rd, 2022 - To prevent the spread of the novel coronavirus disease 2019 (COVID-19) infection, various vaccines have been developed and used in a large number of people worldwide. One of the most commonly used vaccines is the mRNA vaccine developed by Moderna. Although several studies have shown this vaccine to be safe, the full extent of its side effects has not yet been known. Miller-Fisher syndrome (MFS)...

DOCK2 is involved in the host genetics and biology of severe COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492544
Nature Namkoong H, Edahiro R et. al.

Aug 9th, 2022 - Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge1-5. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3,289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cyt...

Cytoplasmic IGF2BP2 Protein Expression in Human Patients with Oral Squamous Cell Carcin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339407
International Journal of Medical Sciences; Lin SH, Lin CW et. al.

Aug 4th, 2022 - Oral squamous cell carcinoma (OSCC) is particularly prevalent in Taiwan. The goal of this study was to determine the clinicopathological role of insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) proteins as an indicator of clinical outcomes in OSCC patients. In this study, immunohistochemical (IHC) analysis was used to examine IGF2BP2 protein expression in 244 OSCC patients. We inve...

Effects of circFOXO3 on the Proliferation and Invasion of Liver Cancer Cells by Regulat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303508
Contrast Media & Molecular Imaging; Liu S, Yao M et. al.

Aug 2nd, 2022 - Hepatocellular carcinoma is a malignant disease occurring in the liver and is one of the main causes of death in cancer patients. Tumor cells are the main components of tumors and have a strong proliferative capacity. They are easily transferred to other parts of the body and can produce harmful substances that destroy the normal organ structure and endanger human life and health. In this study...