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About 131,863 results

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
https://doi.org/10.1002/art.41752
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

A TRPM7 mutation linked to familial trigeminal neuralgia: Omega current and hyperexcita...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499596
Proceedings of the National Academy of Sciences of the Un... Gualdani R, Gailly P et. al.

Sep 13th, 2022 - Trigeminal neuralgia (TN) is a unique pain disorder characterized by intense paroxysmal facial pain within areas innervated by the trigeminal nerve. Although most cases of TN are sporadic, familial clusters of TN suggest that genetic factors may contribute to this disorder. Whole-exome sequencing in patients with TN reporting positive family history demonstrated a spectrum of variants of ion ch...

Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436336
Proceedings of the National Academy of Sciences of the Un... Scherer M, Steiner LA et. al.

Aug 27th, 2022 - Deep brain stimulation procedures offer an invaluable opportunity to study disease through intracranial recordings from awake patients. Here, we address the relationship between single-neuron and aggregate-level (local field potential; LFP) activities in the subthalamic nucleus (STN) and thalamic ventral intermediate nucleus (Vim) of patients with Parkinson's disease (n = 19) and essential trem...

A case of Miller Fisher syndrome with delayed onset peripheral facial nerve palsy after...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395791
BMC Neurology; Nanatsue K, Takahashi M et. al.

Aug 23rd, 2022 - To prevent the spread of the novel coronavirus disease 2019 (COVID-19) infection, various vaccines have been developed and used in a large number of people worldwide. One of the most commonly used vaccines is the mRNA vaccine developed by Moderna. Although several studies have shown this vaccine to be safe, the full extent of its side effects has not yet been known. Miller-Fisher syndrome (MFS)...

Cytoplasmic IGF2BP2 Protein Expression in Human Patients with Oral Squamous Cell Carcin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339407
International Journal of Medical Sciences; Lin SH, Lin CW et. al.

Aug 4th, 2022 - Oral squamous cell carcinoma (OSCC) is particularly prevalent in Taiwan. The goal of this study was to determine the clinicopathological role of insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) proteins as an indicator of clinical outcomes in OSCC patients. In this study, immunohistochemical (IHC) analysis was used to examine IGF2BP2 protein expression in 244 OSCC patients. We inve...

Characterization of T cell receptors reactive to HCRTNH2, pHA273-287, and NP17-31 in co...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371724
Proceedings of the National Academy of Sciences of the Un... Luo G, Zhang J et. al.

Aug 2nd, 2022 - Narcolepsy type 1 (NT1), a disorder caused by hypocretin/orexin (HCRT) cell loss, is associated with human leukocyte antigen (HLA)-DQ0602 (98%) and T cell receptor (TCR) polymorphisms. Increased CD4+ T cell reactivity to HCRT, especially DQ0602-presented amidated C-terminal HCRT (HCRTNH2), has been reported, and homology with pHA273-287 flu antigens from pandemic 2009 H1N1, an established trigg...

Effects of circFOXO3 on the Proliferation and Invasion of Liver Cancer Cells by Regulat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303508
Contrast Media & Molecular Imaging; Liu S, Yao M et. al.

Aug 2nd, 2022 - Hepatocellular carcinoma is a malignant disease occurring in the liver and is one of the main causes of death in cancer patients. Tumor cells are the main components of tumors and have a strong proliferative capacity. They are easily transferred to other parts of the body and can produce harmful substances that destroy the normal organ structure and endanger human life and health. In this study...

Acute hepatitis-like presentation with cholestasis of CBFB-MYH11-positive acute myeloid...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339180
Journal of Medical Case Reports; Spinelli I, De Santis A et. al.

Jul 31st, 2022 - Liver involvement in adults with acute myeloid leukemia is uncommon. Most of the case reports describe acute liver failure or obstructive jaundice, while acute hepatitis is rarely mentioned. We report a patient with acute myeloid leukemia who presented with clinical, biochemical, and radiological signs of acute hepatitis that totally regressed after chemotherapy. A 38-year-old Caucasian man pre...

Role of Tfh17 cells in patients with multiple myeloma.
https://doi.org/10.1080/16078454.2022.2106400
Hematology (Amsterdam, Netherlands); Ye C, Xu Y et. al.

Jul 30th, 2022 - Objective Follicular helper T cells (Tfh) drive proliferation and differentiation of B cells into plasma cells, leading to antibody production; however, their role in multiple myeloma (MM) is unknown. We aimed to determine the alteration of Tfh subsets and their clinical significance in patients with MM.Method Forty-nine patients with MM were recruited in this study, including 12 newly diagnose...

Hemodynamic changes during the obliteration process for cerebral arteriovenous malforma...
https://doi.org/10.3171/2022.4.FOCUS2214
Neurosurgical Focus; Takeda Y, Hasegawa H et. al.

Jul 29th, 2022 - The process of cerebral arteriovenous malformation (AVM) obliteration following radiosurgery is poorly understood. Authors of this retrospective study aimed to assess the changes in AVM hemodynamics after stereotactic radiosurgery (SRS) by using 3D flow magnetic resonance imaging (MRI) to elucidate the process of AVM obliteration. Twenty-four patients with AVMs treated with SRS between July 201...

Hearing and Disease-Specific Health-Related Quality of Life in Patients with Otoscleros...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404310
The Journal of International Advanced Otology; Hildebrandt M, Jensen MM et. al.

Jul 28th, 2022 - The study aims to investigate the effect of stapedotomy on audiology measurements and the disease-specific health-related quality of life for patients with otosclerosis using the Danish Stapesplasty Outcome Test-25 as a quality of life measuring tool. In this study, 50 patients who had undergone stapedotomy at our department between September 2017 and December 2020 were included. Data collectio...

Passive mechanical properties of the left ventricular myocardium and extracellular matr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309441
Physiological Reports; Corporan D, Saadeh M et. al.

Jul 26th, 2022 - Cardiac volume overload from mitral regurgitation (MR) is a trigger for left ventricular dilatation, remodeling, and ultimate failure. While the functional and structural adaptations to this overload are known, the adaptation of myocardial mechanical properties remains unknown. Using a rodent model of MR, in this study, we discern changes in the passive material properties of the intact and dec...

Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by singl...
https://doi.org/10.1038/s41593-022-01124-3
Nature Neuroscience; Gerrits E, Giannini LAA et. al.

Jul 26th, 2022 - Frontotemporal dementia (FTD) is the second most prevalent form of early-onset dementia, affecting predominantly frontal and temporal cerebral lobes. Heterozygous mutations in the progranulin gene (GRN) cause autosomal-dominant FTD (FTD-GRN), associated with TDP-43 inclusions, neuronal loss, axonal degeneration and gliosis, but FTD-GRN pathogenesis is largely unresolved. Here we report single-n...

Tidal volume challenge to predict preload responsiveness in patients with acute respira...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294836
Critical Care (London, England); Shi R, Ayed S et. al.

Jul 20th, 2022 - Prone position is frequently used in patients with acute respiratory distress syndrome (ARDS), especially during the Coronavirus disease 2019 pandemic. Our study investigated the ability of pulse pressure variation (PPV) and its changes during a tidal volume challenge (TVC) to assess preload responsiveness in ARDS patients under prone position. This was a prospective study conducted in a 25-bed...

Use of accelerometry to investigate standing and dynamic body balance in people with ce...
https://doi.org/10.1016/j.gaitpost.2022.06.017
Gait & Posture; Valenciano PJ, Conceição NR et. al.

Jul 13th, 2022 - People with cerebral palsy (CP) often have difficulties related to maintaining body balance in their daily living activities. Accelerometers are low-cost wearable devices with potential use to objectively assess balance. What are the main characteristics and findings from protocols used in research aiming to investigate standing or dynamic body balance stability through trunk accelerometry in p...

Etiology, Pathophysiology and Mortality of Shock in Children in Low (Middle) Income Cou...
https://doi.org/10.1093/tropej/fmac053
Journal of Tropical Pediatrics; Assies R, Snik I et. al.

Jul 8th, 2022 - Shock is a life-threatening condition in children in low- and middle-income countries (LMIC), with several controversies. This systematic review summarizes the etiology, pathophysiology and mortality of shock in children in LMIC. We searched for studies reporting on children with shock in LMIC in PubMed, Embase and through snowballing (up to 1 October 2019). Studies conducted in LMIC that repor...

Long-Term Expanding Porcine Airway Organoids Provide Insights into the Pathogenesis and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327677
Journal of Virology; Jiang C, Li L et. al.

Jun 29th, 2022 - Respiratory coronaviruses cause serious health threats to humans and animals. Porcine respiratory coronavirus (PRCoV), a natural transmissible gastroenteritis virus (TGEV) mutant with partial spike deletion, causes mild respiratory disease and is an interesting animal respiratory coronavirus model for human respiratory coronaviruses. However, the absence of robust ex vivo models of porcine airw...

Multi-centre classification of functional neurological disorders based on resting-state...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240866
NeuroImage. Clinical; Weber S, Heim S et. al.

Jun 26th, 2022 - Patients suffering from functional neurological disorder (FND) experience disabling neurological symptoms not caused by an underlying classical neurological disease (such as stroke or multiple sclerosis). The diagnosis is made based on reliable positive clinical signs, but clinicians often require additional time- and cost consuming medical tests and examinations. Resting-state functional conne...

Pre-operative exercise and pyrexia as modifying factors in malignant hyperthermia (MH).
https://doi.org/10.1016/j.nmd.2022.06.003
Neuromuscular Disorders : NMD; Riazi S, Bersselaar LRVD et. al.

Jun 24th, 2022 - Malignant hyperthermia (MH) is a life-threatening reaction triggered by volatile anesthetics and succinylcholine. MH is caused by mutations in the skeletal muscle ryanodine receptor (RYR1) gene, as is rhabdomyolysis triggered by exertion and/or pyrexia. The discrepancy between the prevalence of risk genotypes and actual MH incidence remains unexplained. We investigated the role of pre-operative...

A syntax-lexicon trade-off in language production.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231468
Proceedings of the National Academy of Sciences of the Un... Rezaii N, Mahowald K et. al.

Jun 17th, 2022 - Spoken language production involves selecting and assembling words and syntactic structures to convey one's message. Here we probe this process by analyzing natural language productions of individuals with primary progressive aphasia (PPA) and healthy individuals. Based on prior neuropsychological observations, we hypothesize that patients who have difficulty producing complex syntax might choo...