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About 131,310 results

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
https://doi.org/10.1002/art.41752
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

Ocular and Hemodynamic Factors Contributing to the Central Visual Function in Glaucoma ...
https://doi.org/10.1167/iovs.63.5.26
Investigative Ophthalmology & Visual Science; Hong KE, Kim SA et. al.

May 24th, 2022 - The purpose of this study was to investigate the ocular and hemodynamic factors contributing to the central visual function in glaucoma patients with myopia. This study was a prospective observational study, which included 236 eyes of 140 patients with normal-tension glaucoma (NTG), which includes 114 eyes with mild myopia (axial length ≥24 and <26 mm) and 122 eyes with moderate-to-severe myopi...

Long COVID: A proposed hypothesis-driven model of viral persistence for the pathophysio...
https://doi.org/10.2500/aap.2022.43.220018
Allergy and Asthma Proceedings; Buonsenso D, Piazza M et. al.

May 8th, 2022 - Background: Long COVID (coronavirus disease 2019) syndrome includes a group of patients who, after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibit lingering mild-to-moderate symptoms and develop medical complications that can have lasting health problems. In this report, we propose a model for the pathophysiology of the long COVID presentation based on incre...

Mesenchymal stromal cells from a progressive pseudorheumatoid dysplasia patient show al...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036808
European Journal of Medical Research; Pulsatelli L, Manferdini C et. al.

Apr 26th, 2022 - Progressive pseudorheumatoid dysplasia (PPRD) is a rare autosomal recessive non-inflammatory skeletal disease with childhood onset and is characterized by a progressive chondropathy in multiple joints, and skeletal abnormalities. To date, the etiopathological relationship between biological modification occurring in PPRD and genetic mutation remains an open issue, partially due to the limited a...

Vitronectin, a Novel Urinary Proteomic Biomarker, Promotes Cell Pyroptosis in Juvenile ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020974
Mediators of Inflammation; Zhang S, Pan W et. al.

Apr 26th, 2022 - Identifying new markers of juvenile systemic lupus erythematosus (JSLE) is critical event to predict patient stratification and prognosis. The aim of the present study is to analyze alteration of urinary protein expression and screen potential valuable biomarkers in juvenile systemic lupus erythematosus (JSLE). The urine was collected from the patients with or without JSLE and detected by mass ...

Immune dysfunction in the cerebellum of mice lacking the autism candidate gene Engraile...
https://doi.org/10.1016/j.jneuroim.2022.577870
Journal of Neuroimmunology; Pangrazzi L, Genovesi S et. al.

Apr 26th, 2022 - Immune system dysfunction has been described in autism spectrum disorder. Here we tested the hypothesis that cerebellar defects are accompanied by immune dysfunction in adult mice lacking the autism-candidate gene Engrailed 2 (En2). Gene ontology analyses revealed that biological processes related to immune function were over-represented in the cerebellar transcriptome of En2-/- mice. Pro-infla...

One year monitoring of SARS-CoV-2 prevalence in a German cohort of patients with cystic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943512
BMC Pulmonary Medicine; Jaudszus A, Pavlova M et. al.

Mar 26th, 2022 - In Germany, the first case of coronavirus disease 2019 (COVID-19) was registered on 28 January 2020. By February 2021, the third wave of the pandemic began. So far, only few data are available on the SARS-CoV-2 prevalence and the clinical impact of an infection in patients with cystic fibrosis (CF). From February 2020 until March 2021, we screened 156 CF patients for anti-SARS-CoV-2 IgG antibod...

Acute rhabdomyolysis in hepatitis-associated aplastic anemia patient undergoing allogen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935704
European Journal of Medical Research; Li Y, Hong Y et. al.

Mar 23rd, 2022 - Hepatitis-associated aplastic anemia (HAAA) is a specific type of aplastic anemia, and hematopoietic stem-cell transplantation (HSCT) is recommended as the first-line. Acute rhabdomyolysis (AR) during hematopoietic stem-cell transplantation (HSCT) is a rare, serious complication, with only 10 cases reported in the world so far. Herein, we present a case of AR developing during HLA-haploidentica...

Identification of differentially expressed genes and signaling pathways with Candida in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935812
European Journal of Medical Research; Zhu GD, Xie LM et. al.

Mar 23rd, 2022 - Opportunistic Candida species causes severe infections when the human immune system is weakened, leading to high mortality. In our study, bioinformatics analysis was used to study the high-throughput sequencing data of samples infected with four kinds of Candida species. And the hub genes were obtained by statistical analysis. A total of 547, 422, 415 and 405 differentially expressed genes (DEG...

Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vas...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993480
Clinical Journal of the American Society of Nephrology : ... Kramers BJ, Koorevaar IW et. al.

Mar 23rd, 2022 - The vasopressin V2 receptor antagonist tolvaptan is the only drug that has been proven to be nephroprotective in autosomal dominant polycystic kidney disease (ADPKD). Tolvaptan also causes polyuria, limiting tolerability. We hypothesized that cotreatment with hydrochlorothiazide or metformin may ameliorate this side effect. We performed a clinical study and an animal study. In a randomized, con...

Pyroptosis Patterns Are Involved in Immune Microenvironment Regulation of Dilated Cardi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930255
Disease Markers; Wang K, Lv Z et. al.

Mar 22nd, 2022 - The importance of cell pyroptosis in immunity regulation is becoming increasingly obvious, especially in diseases of the cardiovascular system. Nevertheless, it is unknown whether the pyroptosis signalling pathway is involved in the immune microenvironment regulation of dilated cardiomyopathy (DCM). Therefore, the purpose of the study was to investigate the influence of pyroptosis on the immune...

Monitoring respiratory mechanics by oscillometry in COVID-19 patients receiving non-inv...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936489
PloS One; Torregiani C, Veneroni C et. al.

Mar 22nd, 2022 - Non-invasive ventilation (NIV) has been increasingly used in COVID-19 patients. The limited physiological monitoring and the unavailability of respiratory mechanic measures, usually obtainable during invasive ventilation, is a limitation of NIV for ARDS and COVID-19 patients management. This pilot study was aimed to evaluate the feasibility of non-invasively monitoring respiratory mechanics by ...

Mind the gap: IgG4-related disease mimicking infectious cerebral mass lesions.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933968
European Journal of Medical Research; De Maria A, Sepulcri C et. al.

Mar 21st, 2022 - Cerebral intraparenchymal masses represent usually a neoplastic, or infectious differential diagnostic workup in neurology or infectious disease units. Our patient was an 82-year-old male presenting with seizures, cerebral masses and a history of past treated pulmonary tuberculosis. Initial workup included a differential diagnosis of an infectious mass/multiple abscess. After exclusion of infec...

A mini-whole lung lavage to treat autoimmune pulmonary alveolar proteinosis (PAP).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932062
Respiratory Research; Mariani F, Salvaterra E et. al.

Mar 19th, 2022 - PAP is an ultra-rare respiratory syndrome characterized by the accumulation of surfactant within the alveoli. Whole lung lavage (WLL) is the current standard of care of PAP, however it is not a standardized procedure and the total amount of fluid used to wash each lung is still debated. Considering ICU hospitalization associated risks, a "mini-WLL" with anticipated manual clapping and reduced t...

Cryptogenic Organizing Pneumonia.
https://doi.org/10.1056/NEJMra2116777
The New England Journal of Medicine; King TE, Lee JS

Mar 17th, 2022 - Cryptogenic Organizing Pneumonia.|2022|King TE,Lee JS,|diagnosis,drug therapy,pathology,physiopathology,therapeutic use,diagnostic imaging,pathology,

Functional Brain Organization Differences Found Between Boys and Girls With Autism Spec...
https://doi.org/10.1001/jama.2022.3834
JAMA Rubin R

Mar 17th, 2022 - Functional Brain Organization Differences Found Between Boys and Girls With Autism Spectrum Disorder.|2022|Rubin R,|physiopathology,diagnostic imaging,physiopathology,

Migraine-Associated Mutation in the Na,K-ATPase Leads to Disturbances in Cardiac Metabo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075430
Journal of the American Heart Association; Staehr C, Rohde PD et. al.

Mar 16th, 2022 - Background Mutations in ATP1A2 gene encoding the Na,K-ATPase α2 isoform are associated with familial hemiplegic migraine type 2. Migraine with aura is a known risk factor for heart disease. The Na,K-ATPase is important for cardiac function, but its role for heart disease remains unknown. We hypothesized that ATP1A2 is a susceptibility gene for heart disease and aimed to assess the underlying di...

Fluorometholone inhibits high glucose-induced cellular senescence in human retinal endo...
https://doi.org/10.1177/09603271221076107
Human & Experimental Toxicology; Zhou X, Wang L et. al.

Mar 11th, 2022 - Diabetic retinopathy (DR) is a common diabetic complication that severely impacts the life quality of diabetic patients. Recently, cellular senescence in human retinal endothelial cells (HRECs) induced by high glucose has been linked to the pathogenesis of DR. Fluorometholone (FML) is a glucocorticoid drug applied in the treatment of inflammatory and allergic disorders of the eye. The objective...

Investigating the impact of SARS-CoV-2 infection on basic semen parameters and in vitro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901866
Reproductive Biology and Endocrinology : RB&E; Wang M, Hu J et. al.

Mar 10th, 2022 - This study aimed to evaluate the influences of SARS-CoV-2 infection on semen parameters and investigate the impact of the infection on in vitro fertilization (IVF) outcomes. This retrospective study enrolled couples undergoing IVF cycles between May 2020 and February 2021 at Tongji Hospital, Wuhan. Baseline characteristics were matched using propensity score matching. Participants were categori...

Poly-dipeptides produced from C9orf72 hexanucleotide repeats cause selective motor neur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931230
Proceedings of the National Academy of Sciences of the Un... Jo Y, Lee J et. al.

Mar 9th, 2022 - SignificanceThe GGGGCC hexanucleotide repeat expansion in the chromosome 9 open reading frame 72 (C9orf72) gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS). Despite myriad studies on the toxic effects of poly-dipeptides produced from the C9orf72 repeats, the mechanisms underlying the selective hyperexcitability of motor cortex that characterizes the early stages of C...