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About 123,350 results

Impact of Frailty on Treatment Outcome in Patients With Locally Advanced Esophageal Can...
https://doi.org/10.21873/anticanres.15340
Anticancer Research; Huang YH, Hung YS et. al.

Oct 2nd, 2021 - The clinical significance of frailty status on treatment outcome in patients with esophageal cancer (EC) has been seldom explored. This study aimed to evaluate the impact of pretreatment frailty on treatment-related toxicity and survival outcome in patients with EC undergoing concurrent chemoradiotherapy (CCRT). Patients aged ≥20 years and with newly diagnosed locally advanced EC receiving neoa...

Roadmap to cure multiple myeloma.
https://doi.org/10.1016/j.ctrv.2021.102284
Cancer Treatment Reviews; Rodriguez-Otero P, Paiva B et. al.

Oct 2nd, 2021 - Despite significant advances in the treatment of multiple myeloma which had led to unprecedented rates of response and survival, patients still relapse, and cure remains elusive. We propose in this review a roadmap to achieve the dream of cure for multiple myeloma based on five complementary strategies. First, to increase knowledge about disease pathogenesis with a focus on the biology of circu...

One Year of the COVID-19 Pandemic. What Do We Know and What Is Yet to Come? - The Summa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475762
International Journal of Public Health; Malchrzak W, Mastalerz-Migas A et. al.

Oct 1st, 2021 - Objectives: The aim of this review is to summarize the most relevant scientific discoveries regarding SARS- CoV-2 virus infection, with the special emphasis put on its pathophysiology and way of treatment. Methods: In November 2020, the research articles have been collected and examined manually to pick the most relevant. In case of fresh topics, e.g. vaccines, we have performed searching using...

Protective Effect of Isopulegol in Alleviating Neuroinflammation in Lipopolysaccharide-...
https://doi.org/10.1615/JEnvironPatholToxicolOncol.2021038944
Journal of Environmental Pathology, Toxicology and Oncolo... Kang B, Li N et. al.

Sep 30th, 2021 - Parkinson's disease (PD) is the most prevalent disease linked with age-associated neuronal degeneration. Phytotherapeutic compounds or agents have gained increased importance because of their increased specificity and minimal side effects. Isopulegol, a monoterpene, was utilized in the present study because of its wide range of therapeutic properties. Our aim was to examine the underlying mecha...

Toxoplasmosis is a risk factor for acquiring SARS-CoV-2 infection and a severe course o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477627
Parasites & Vectors; Flegr J

Sep 30th, 2021 - Latent toxoplasmosis, i.e. a lifelong infection with the protozoan parasite Toxoplasma gondii, affects about a third of the human population worldwide. In the past 10 years, numerous studies have shown that infected individuals have a significantly higher incidence of mental and physical health problems and are more prone to exhibiting the adverse effects of various diseases. A cross-sectional ...

Case report: a 5-year-old with new onset nephrotic syndrome in the setting of COVID-19 ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476119
BMC Nephrology; Morgan KM, Imani PD

Sep 29th, 2021 - This is a case report of an asymptomatic SARS-CoV-2 infection associated with new-onset nephrotic syndrome in a pediatric patient. This is the third case of new-onset nephrotic syndrome in children associated with SARS-CoV-2 infection, but is the first case report describing a new-onset nephrotic syndrome presentation in a patient who had asymptomatic COVID-19 infection. This is a case of a pre...

Factors affecting duration of SARS-Cov-2 viral shedding in mildly symptomatic patients ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476038
PloS One; Cheng HM, Zhao X et. al.

Sep 28th, 2021 - Mildly symptomatic cases of Covid-19 in previously-well individuals form the majority of infections and also serve as potent vectors of transmission. The factors affecting the duration of SARS-CoV-2 RNA viral shedding (DVS) in these patients remain largely unknown. To perform a systematic analysis of the clinical, radiologic, laboratory investigations in patients with few comorbidities infected...

Cutaneous Pathology of COVID-19 as a Window into Immunologic Mechanisms of Disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297957
Dermatologic Clinics; Gallman AE, Fassett MS

Sep 25th, 2021 - Many skin manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection reflect activation of cutaneous and systemic immune responses involving effector pathways of both the innate and adaptive arms of the immune system. This article reviews evidence from the recent clinical and scientific literature that informs the current understanding of the consequences of corona...

eARDS: A multi-center validation of an interpretable machine learning algorithm of earl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462682
PloS One; Singhal L, Garg Y et. al.

Sep 25th, 2021 - We present an interpretable machine learning algorithm called 'eARDS' for predicting ARDS in an ICU population comprising COVID-19 patients, up to 12-hours before satisfying the Berlin clinical criteria. The analysis was conducted on data collected from the Intensive care units (ICU) at Emory Healthcare, Atlanta, GA and University of Tennessee Health Science Center, Memphis, TN and the Cerner® ...

COVID-19 pandemic restrictions continuously impact on physical activity in adults with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460042
PloS One; Radtke T, Haile SR et. al.

Sep 24th, 2021 - We have recently reported reduced physical activity (PA) in people with cystic fibrosis (pwCF) with and without lung transplantation (LTX) during a 6-week stringent lockdown in Switzerland. This follow-up study explores the impact of coronavirus-2019 disease (COVID-19) related pandemic restrictions on individuals' therapy regimens and health-related aspects in pwCF. We conducted a cross-section...

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific altera...
https://doi.org/10.1073/pnas.2109123118
Proceedings of the National Academy of Sciences of the Un... Lourda M, Dzidic M et. al.

Sep 23rd, 2021 - Since the outset of the COVID-19 pandemic, increasing evidence suggests that the innate immune responses play an important role in the disease development. A dysregulated inflammatory state has been proposed as a key driver of clinical complications in COVID-19, with a potential detrimental role of granulocytes. However, a comprehensive phenotypic description of circulating granulocytes in seve...

Identification of limb-specific Lmx1b auto-regulatory modules with Nail-patella syndrom...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452625
Nature Communications; Haro E, Petit F et. al.

Sep 22nd, 2021 - LMX1B haploinsufficiency causes Nail-patella syndrome (NPS; MIM 161200), characterized by nail dysplasia, absent/hypoplastic patellae, chronic kidney disease, and glaucoma. Accordingly in mice, Lmx1b has been shown to play crucial roles in the development of the limb, kidney and eye. Although one functional allele of Lmx1b appears adequate for development, Lmx1b null mice display ventral-ventra...

Pediatric Rheumatologic Effects of COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445755
Pediatric Clinics of North America; El-Hor N, Adams M

Sep 21st, 2021 - A multisystem inflammatory syndrome (MISC) can result from COVID-19 infection in previously healthy children and adolescents. It is potentially life threatening and is treated initially with intravenous immunoglobulin and aspirin but may require anti-inflammatory monoclonal antibody treatment in severe cases. SARS-CoV-2 infection can cause macrophage activation syndrome, chilblains, and flares ...

Electrophysiological and olfactometric evaluation of long-term COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449286
Physiological Reports; Mazzatenta A, Montagnini C et. al.

Sep 19th, 2021 - COVID-19 is a public health emergency with cases increasing globally. Its clinical manifestations range from asymptomatic and acute respiratory disease to multiple organ dysfunction syndromes and effects of COVID-19 in the long term. Interestingly, regardless of variant, all COVID-19 share impairment of the sense of smell and taste. We would like to report, as far as we know, the first comprehe...

Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome.
https://doi.org/10.1183/16000617.0059-2021
European Respiratory Review : an Official Journal of the ... Gierhardt M, Pak O et. al.

Sep 17th, 2021 - Acute respiratory distress syndrome (ARDS) is a serious complication of severe systemic or local pulmonary inflammation, such as caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. ARDS is characterised by diffuse alveolar damage that leads to protein-rich pulmonary oedema, local alveolar hypoventilation and atelectasis. Inadequate perfusion of these areas is the m...

Hereditary Hemochromatosis: Rapid Evidence Review.
https://www.ncbi.nlm.nih.gov/pubmed/34523883
American Family Physician; Kane SF, Roberts C et. al.

Sep 16th, 2021 - Hereditary hemochromatosis is an autosomal recessive disorder that disrupts iron homeostasis, resulting in systemic iron overload. It is the most common inherited disorder among people of northern European ancestry. Despite the high prevalence of the gene mutation, there is a low and variable clinical penetrance. The deposition of excess iron into parenchymal cells leads to cellular dysfunction...

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Com...
https://www.ncbi.nlm.nih.gov/pubmed/34523885
American Family Physician; Darby JB, Jackson JM

Sep 16th, 2021 - Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) are inflammatory conditions that present diagnostic and therapeutic challenges to the physician. Although many of their features overlap, they are two distinct conditions. KD is a febrile illness most commonly affecting children younger than five years. It manifests with prolonged fever and at least four of the foll...

Neglected Parasitic Infections: What Family Physicians Need to Know-A CDC Update.
https://www.ncbi.nlm.nih.gov/pubmed/34523888
American Family Physician; Cantey PT, Montgomery SP et. al.

Sep 16th, 2021 - Chagas disease, cysticercosis, and toxoplasmosis affect millions of people in the United States and are considered neglected parasitic diseases. Few resources are devoted to their surveillance, prevention, and treatment. Chagas disease, transmitted by kissing bugs, primarily affects people who have lived in Mexico, Central America, and South America, and it can cause heart disease and death if ...

Possible mechanisms of cholesterol elevation aggravating COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436106
International Journal of Medical Sciences; Tang Y, Hu L et. al.

Sep 16th, 2021 - Importance: Despite the availability of a vaccine against the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), humans will have to live with this virus and the after-effects of the coronavirus disease 2019 (COVID-19) infection for a long time. Cholesterol plays an important role in the infection and prognosis of SARS-CoV-2, and the study of its mechanism is of great significance no...

Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441591
JAMA , Schwarzschild MA et. al.

Sep 15th, 2021 - Urate elevation, despite associations with crystallopathic, cardiovascular, and metabolic disorders, has been pursued as a potential disease-modifying strategy for Parkinson disease (PD) based on convergent biological, epidemiological, and clinical data. To determine whether sustained urate-elevating treatment with the urate precursor inosine slows early PD progression. Randomized, double-blind...