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About 1,595 results

BT-011 Pharmacokinetics of Botulism Antitoxin Heptavalent in Pediatric Patients
https://clinicaltrials.gov/ct2/show/NCT02051062

May 6th, 2022 - Objectives: The purpose of this study is to collect serum from pediatric patients to analyze the pharmacokinetics (PK) of BAT® product to verify the currently approved pediatric dosing recommendations. Protocol Design: This is a single arm, multi-site PK study in pediatric patients treated with BAT® product. The study begins once participation in the study is confirmed by the physician and info...

Gastrointestinal Infections Halved During Early Months of the Pandemic
https://www.medscape.com/viewarticle/970711

Mar 22nd, 2022 - The number of gastrointestinal infection (GI) outbreaks in England more than halved during the first 6 months of the COVID-19 pandemic compared with a 5-year average, a study found. Several factors might be involved in the decline, but changes in behaviour and improved hygiene that accompanied efforts to combat SARS-CoV-2 were likely to have had a key role, researchers said. The retrospective e...

Rituximab, Bendamustine Hydrochloride, and Bortezomib Followed by Rituximab and Lenalidomide in Treating Older Patients With Previously Untreated Mantle Cell Lymphoma
https://clinicaltrials.gov/ct2/show/NCT01415752

Jan 3rd, 2022 - OBJECTIVES: Primary To determine whether the addition of bortezomib (RBV) to an induction regimen of rituximab-bendamustine hydrochloride (RB) improves progression-free survival (PFS) compared to RB alone in patients ≥ 60 years of age with previously untreated mantle cell lymphoma. To determine whether the addition of lenalidomide to a consolidation regimen of rituximab following an induction r...

Beware of Neurotoxins in Common Plants: Water Hemlock Poisoning Presenting as Convulsiv...
https://doi.org/10.1016/j.pediatrneurol.2021.11.011
Pediatric Neurology; Arsenova R, Prager C et. al.

Dec 27th, 2021 - Pediatric status epilepticus occurs in about 44/100.000 children per year with an unknown cause in about a third of patients. One cause can be the ingestion of plants containing toxins that target the central nervous system. Here we describe an ingestion of water hemlock resulting in a status epilepticus. We studied in detail the clinical, laboratory, electrophysiological, and radiological feat...

Five-Drug Combination Shows Benefit in Ultra-High Risk Multiple Myeloma
https://www.medscape.com/viewarticle/964787

Dec 14th, 2021 - A team of researchers from The Institute of Cancer Research in London and the Clinical Trials Research Unit at the University of Leeds has identified a new five-drug combination that significantly improves progression-free survival (PFS) in patients with ultra-high risk (UHiR) newly diagnosed multiple myeloma (NDMM) or primary plasma cell leukaemia (pPCL). In a study presented Sunday at the Ame...

Evaluation of the Improvement of Quality of Life of Patients Suffering From Hailey Hailey or Darier Disease After Injections of Botulism Toxin Into Large Folds.
https://clinicaltrials.gov/ct2/show/NCT02782702

Dec 13th, 2021 - Hailey Hailey and Darier disease are rare genetic dermatoses. Mutations of 2 genes (ATP2C1 or ATP2A2 respectively) are responsible for the diseases. These genes have a key role in calcium pump; their defect create abnormal link between keratinocytes' desmosomes and induce skin lesions. Clinically, patients present with inflammatory lesions located in the folds. Quality of life is impaired becau...

New COVID-19 Vaccine Shows Good Efficacy and Toxicity Profile
https://www.medscape.com/viewarticle/963231

Nov 18th, 2021 - A randomised, double-blind, placebo-controlled, multicentre, phase 3 clinical trial has found that a new SARS-CoV-2 vaccine is “highly efficacious against laboratory-confirmed symptomatic COVID-19 disease”. Covaxin (code-named BBV152) is a whole virion inactivated SARS-CoV-2 vaccine, formulated with a toll-like receptor 7/8 agonist molecule adsorbed with alum (Algel-IMDG). It has been developed...

Study to Assess Prevention of Oxaliplatin-induced Neurotoxicity Through Vitamin D Pathway
https://clinicaltrials.gov/ct2/show/NCT01499940

Nov 10th, 2021 - Oxaliplatin is used most frequently in patients with metastatic and early-stage colorectal cancers. It has been found that in the adjuvant setting, Oxaliplatin improves both disease free and overall survival. Despite these results, the use of Oxaliplatin is limited by the sensory neuropathy or numbness and tingling, that occurs in 80% -90% of patients. Some of these patients will develop irreve...

Occupational insecticide exposure and risk of non-Hodgkin lymphoma: A pooled case-contr...
https://doi.org/10.1002/ijc.33740
International Journal of Cancer; De Roos AJ, Schinasi LH et. al.

Jul 17th, 2021 - Evidence for the human health effects of pesticides is needed to inform risk assessment. We studied the relationship between occupational insecticide use and risk of non-Hodgkin lymphoma (NHL) by pooling data from nine case-control studies participating in the InterLymph Consortium, including 7909 cases and 8644 controls from North America, the European Union and Australia. Insecticide use was ...

Extracorporeal treatments for isoniazid poisoning: Systematic review and recommendation...
https://doi.org/10.1002/phar.2519
Pharmacotherapy Mowry JB, Shepherd G et. al.

Mar 5th, 2021 - Isoniazid toxicity from self-poisoning or dosing errors remains common in regions of the world where tuberculosis is prevalent. Although the treatment of isoniazid poisoning is centered on supportive care and pyridoxine administration, extracorporeal treatments (ECTRs), such as hemodialysis, have been advocated to enhance elimination of isoniazid. No systematic reviews or evidence-based recomme...

Physiologic and biochemical rationale for treating COVID-19 patients with hyperbaric ox...
https://www.ncbi.nlm.nih.gov/pubmed/33648028
Undersea & Hyperbaric Medicine : Journal of the Undersea ... Feldmeier JJ, Kirby JP et. al.

Mar 2nd, 2021 - The SARS-Cov-2 (COVID-19) pandemic remains a major worldwide public health issue. Initially, improved supportive and anti-inflammatory intervention, often employing known drugs or technologies, provided measurable improvement in management. We have recently seen advances in specific therapeutic interventions and in vaccines. Nevertheless, it will be months before most of the world's population ...

BT-010 Registry for the Evaluation of Safety and Clinical Outcomes in Patients Treated With Botulinum Antitoxin
https://clinicaltrials.gov/ct2/show/NCT02055183

Feb 17th, 2021 - A full description of the patient registry can be found in the paper titled: Safety and Clinical Outcomes of an Equine-derived Heptavalent Botulinum Antitoxin Treatment for Confirmed or Suspected Botulism in the United States. Richardson JS, Parrera GS, Astacio H, Sahota H, Anderson DM, Hall C, Babinchak T. Clin Infect Dis. 2019 Apr 15;70(9):1950-1957.

Acute Trimethyltin Poisoning Caused by Exposure to Polyvinyl Chloride Production: 8 Cases.
https://doi.org/10.1016/j.amjms.2021.02.010
The American Journal of the Medical Sciences; Du Y

Feb 16th, 2021 - This manuscript aimed to describe and analyze acute trimethyltin poisoning caused by exposure to polyvinyl chloride production and review the literature. Combined with an analysis of occupational hygiene survey data, the clinical data of 8 cases of acute trimethyltin poisoning were analyzed retrospectively. The clinical manifestations of acute trimethyltin poisoning are mainly related to centra...

Glyphosate poisoning - a case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098880
Journal of Postgraduate Medicine; Kunapareddy T, Kalisetty S

Feb 4th, 2021 - Glyphosate is the most commonly used broad-spectrum, non-selective herbicide in the world. The toxicity is supposed to be due to uncoupling of oxidative phosphorylation and the surfactant polyoxyethylene amine (POEA)- mediated cardiotoxicity. Clinical features of this herbicide poisoning are varied, ranging from asymptomatic to even death. There is no antidote and aggressive supportive therapy ...

Reversible cerebral vasoconstriction syndrome (RCVS) caused by over-the-counter calcium...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845714
BMJ Case Reports; Schertz AR, Sarma AK et. al.

Jan 30th, 2021 - A 59-year-old woman was found unresponsive at home. Initial neurologic examination revealed aphasia and right-sided weakness. Laboratory results demonstrated a serum calcium level of 17.3 mg/dL (corrected serum calcium for albumin concentration was 16.8 mg/dL). Extensive workup for intrinsic aetiology of hypercalcemia was unrevealing. Further discussion with family members and investigation of ...

Suicidal attempt with caffeine overdose treated with dexmedetomidine: a case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811210
Journal of Medical Case Reports; Kitano T, Okajima M et. al.

Jan 17th, 2021 - Caffeine is a widely used dietary stimulant, and cases of caffeine overdoses, sometimes leading to death, are increasing. We encountered a case of caffeine intoxication resolved with administration of the sedative agent dexmedetomidine. We administered dexmedetomidine for sedation and to suppress sympathetic nerve stimulation in the case of an 18-year-old Japanese male who ingested a massive do...

Hyperbaric Oxygen for Carbon Monoxide Induced Chronic Encephalopathy
https://clinicaltrials.gov/ct2/show/NCT04118491

Nov 19th, 2020 - Project title Hyperbaric Oxygen for Carbon Monoxide induced Chronic Encephalopathy Principle investigator(s) Jeffrey Cooper, MD Diego Torres-Russo, MD Participating institution(s) UNMC, Departments of Emergency Medicine and Neurology Study aims, hypotheses, methods (brief overview of design, sample, measures, budget and statistical analysis plan) a. Design i. prospective, blinded sham controlle...

Clinical Practice Guidelines on Chronic Myeloid Leukemia (NCCN, 2020)
https://reference.medscape.com/viewarticle/939995

Oct 30th, 2020 - In October 2020, the National Comprehensive Cancer Network (NCCN) released an updated version of its clinical practice guidelines on chronic myeloid leukemia (CML), including on diagnosis and workup, management of chronic-phase CML (CP-CML), and CML management during pregnancy and breastfeeding.[1] Diagnosis and workup A history and physical exam should make up the initial evaluation in chronic...

Acute chloroquine and hydroxychloroquine toxicity: A review for emergency clinicians.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369162
The American Journal of Emergency Medicine; Della Porta A, Bornstein K et. al.

Oct 20th, 2020 - Acute chloroquine and hydroxychloroquine toxicity is characterized by a combination of direct cardiovascular effects and electrolyte derangements with resultant dysrhythmias and is associated with significant morbidity and mortality. This review describes acute chloroquine and hydroxychloroquine toxicity, outlines the complex pathophysiologic derangements, and addresses the emergency department...

How Much Vitamin D is Too Much? A Case Report and Review of the Literature.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811610
Endocrine, Metabolic & Immune Disorders Drug Targets; De Vincentis S, Russo A et. al.

Oct 9th, 2020 - The beneficial effects of vitamin D, together with the high prevalence of vitamin D deficiency, have led to an expanding use of vitamin D analogues. While inappropriate consumption is a recognized cause of harm, the determination of doses at which vitamin D becomes toxic remains elusive. A 56-year woman was admitted to our Hospital following a 3-week history of nausea, vomiting, and muscle weak...