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About 306,343 results

Several pathways under investigation for dry AMD treatment
https://www.healio.com/news/ophthalmology/20220118/several-pathways-under-investigation-for-dry-amd-treatment

Jan 18th, 2022 - WAIKOLOA, Hawaii — Several pathways are under investigation for the treatment of dry age-related macular degeneration, according to a presentation at Retina 2022. “The big issue for us researchers is we don’t have a good animal model to test anything,” Peter K. Kaiser, MD, said. “We don’t have preclinical models that inform us if a drug is going to work or not because the animal that we use are...

Optimization of therapy in patients with epilepsy and psychiatric comorbidities: key po...
https://doi.org/10.2174/1570159X20666220526144314
Current Neuropharmacology; Pisani F, Rosa Pisani L et. al.

May 28th, 2022 - Psychiatric disorder comorbidity in patients with epilepsy (PWE) is very frequent with a mean percentage prevalence of up to 50% and even higher. Such a high frequency suggests that epilepsy and psychiatric disorders might share common pathological pathways. Various aspects contribute to make the matter very complex from a therapeutic point of view. Some antiseizure medications (ASMs), namely v...

Ferroptosis inhibitor regulates the disease progression of systematic lupus erythematos...
https://doi.org/10.2174/1566524022666220525144630
Current Molecular Medicine; Yang B, Hou S et. al.

May 28th, 2022 - Systematic lupus erythematosus (SLE) is an autoimmune-mediated disease. So far, there is no relevant report on ferroptosis in SLE research, and the role of T helper 1 (Th1) and T helper 2 (Th2) cells in SLE is still unclear. This study employed SLE mice models with and without ferroptosis inhibitors(Liproxstatin‑1) and normal control mice. Treated mice were zanalyzed with hematoxylin and eosin ...

Intercellular Communication-Related Molecular Subtypes and a Gene Signature Identified ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127593
Disease Markers; Guan P, Cai W et. al.

May 28th, 2022 - The tumor microenvironment (TME) of lung adenocarcinoma (LUAD) comprise various cell types that communicate with each other through ligand-receptor interactions. This study focused on the identification of cell types in LUAD by single-cell RNA sequencing (scRNA-seq) data and screening of intercellular communication-related genes. The Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm....

Pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects.
https://doi.org/10.1017/S1368980022001318
Public Health Nutrition; Suhl J, Conway KM et. al.

May 28th, 2022 - To explore associations between maternal pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects. Population-based, case-control study using maternal responses to a dietary assessment and published arsenic concentration estimates in food items to calculate average daily total and inorganic arsenic exposure during the year before pregnancy. Assigning tertiles of total and inorgan...

Breathing in Duchenne muscular dystrophy: Translation to therapy.
https://doi.org/10.1113/JP281671
The Journal of Physiology; Mhandire DZ, Burns DP et. al.

May 28th, 2022 - Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disease caused by a deficiency in dystrophin - a structural protein which stabilizes muscle during contraction. Dystrophin deficiency adversely affects the respiratory system leading to sleep-disordered breathing, hypoventilation, and weakness of the expiratory and inspiratory musculature, which culminate in severe respiratory dysfu...

Efficacy and safety of metformin in pregnant women with polycystic ovary syndrome: a sy...
https://doi.org/10.1080/09513590.2022.2080194
Gynecological Endocrinology : the Official Journal of The... Zhao Q, He J

May 28th, 2022 - To evaluate the efficacy and safety of using metformin in pregnant women with polycystic ovarian syndrome (PCOS) and to explore the most effective and safe protocol by using a meta-analysis method. Medline, EMBASE, Cochrane Library, and other databases were searched for randomized controlled trials and prospective cohort studies enrolling pregnant women with PCOS on receiving metformin or place...

Tazemetostat Shows Antitumor Activity in Malignant Pleural Mesothelioma.
https://doi.org/10.1158/2159-8290.CD-RW2022-096
Cancer Discovery;

May 28th, 2022 - The primary endpoint of disease control rate at 12 weeks was met with a partial response in two patients.

STR Profiling Reveals Tumor Genome Instability in Primary Mediastinal B-Cell Lymphoma.
https://doi.org/10.3390/curroncol29050278
Current Oncology (Toronto, Ont.); Risinskaya N, Mangasarova Y et. al.

May 28th, 2022 - Primary mediastinal B-cell lymphoma (PMBCL) is the only non-Hodgkin's lymphoma variant responding to immune checkpoint inhibitor (ICI) therapy, approximately in half of the cases; however, no molecular markers predicting a response to ICI therapy in PMBCL have been described so far. In this study, we assessed the incidence of the loss of heterozygosity (LOH), elevated microsatellite alteration ...

Nucleophosmin 1: from its pathogenic role to a tantalizing therapeutic target in acute ...
https://doi.org/10.1080/16078454.2022.2067939
Hematology (Amsterdam, Netherlands); Shi Y, Xue Y et. al.

May 28th, 2022 - Nucleophosmin 1 (NPM1, also known as B23) is a multifunctional protein involved in a variety of cellular processes, including ribosomal maturation, centrosome replication, maintenance of genomic stability, cell cycle control, and apoptosis. NPM1 is the most commonly mutated gene in adult acute myeloid leukemia (AML) and is present in approximately 40% of all AML cases. The underlying mechanisms...

Risk of intracranial meningioma with three potent progestogens: a population-based case...
https://doi.org/10.1111/ene.15423
European Journal of Neurology; Hoisnard L, Laanani M et. al.

May 28th, 2022 - A dose-dependent association between the use of cyproterone acetate and intracranial meningioma has been identified but data for other potent progestogens are scarce. We assessed the association between intracranial meningioma surgery and exposure to three potent progestogens: cyproterone acetate (CPA; ≥25 mg/day), nomegestrol acetate (NOMAC; 3.75-5 mg/day), and chlormadinone acetate (CMA; 2-10...

Innovations in the Management of Vaginal Cancer.
https://doi.org/10.3390/curroncol29050250
Current Oncology (Toronto, Ont.); Kulkarni A, Dogra N et. al.

May 28th, 2022 - Primary vaginal cancer is a rare gynecologic malignancy. Given the rarity of the disease, standardized approaches to management are limited, and a great variety of therapeutic conditions are endorsed. This paper reviews advances in surgical approaches, radiation, chemoradiation, and immunotherapy. Advances in surgical management including the increasing use of laparoscopic and endoscopic approa...

Children with cystic fibrosis have elevated levels of fecal chitinase-3-like-1.
https://doi.org/10.1097/MPG.0000000000003477
Journal of Pediatric Gastroenterology and Nutrition; Permain J, Appleton L et. al.

May 28th, 2022 - Although chitinase-3-like-1 (CHI3L1), predominately produced by epithelial cells and macrophages, is relevant to pulmonary disease in cystic fibrosis (CF), fecal levels have not yet been assessed in children with CF. Fecal CHI3L1 was measured with a commercial immunoassay using fecal samples provided by children with CF and healthy control children (HC). Higher median (IQR) fecal CHI3L1 levels ...

Preoperative differentiation of hypophysitis and pituitary adenomas using a novel clini...
https://doi.org/10.1007/s11102-022-01232-0 10.1002/path.1700830241 10.1210/er.2004-0011 10.1007/s11102-006-6598-z 10.1530/EJE-17-0009 10.1186/s40842-016-0034-8 10.1007/s11102-016-0769-3 10.1007/s11102-014-0622-5 10.1210/jc.2015-2152 10.1507/endocrj.EJ20-0436 10.1210/jc.2014-4209 10.1016/j.autrev.2008.04.016 10.4103/2230-8210.84871 10.1053/crad.2002.1119 10.3174/ajnr.A1623 10.1097/01.rmr.0000224686.21748.ea 10.1016/j.clinimag.2017.12.014 10.1210/jcem.80.8.7629223 10.3171/jns.2004.101.2.0262 10.3275/7863 10.3174/ajnr.A1714 10.1055/a-1163-7304 10.1007/s12022-019-09581-6 10.1007/s12022-017-9471-x 10.1007/BF02739954 10.1530/eje.1.02183 10.1210/jc.2015-2146 10.1016/j.wneu.2016.07.071 10.3803/EnM.2014.29.4.470 10.1016/j.clineuro.2016.08.011 10.1007/BF01476492 10.1111/cen.13354 10.1016/j.wneu.2019.01.250 10.2214/ajr.159.2.1632360 10.1007/bf00318578 10.1136/jnnp.71.6.798 10.1097/md.0000000000006934 10.1007/s11547-019-01120-x 10.1007/s002340050550 10.1007/s11102-018-0892-4 10.1186/1756-0500-6-560 10.3174/ajnr.A2201 10.1159/000501886 10.1002/cpp.2152
Pituitary Wright K, Kim H et. al.

May 28th, 2022 - Hypophysitis can clinically and radiologically mimic other nonfunctioning masses of the sella turcica, complicating preoperative diagnosis. While sellar masses may be treated surgically, hypophysitis is often treated medically, so differentiating between them facilitates optimal management. The objective of our study was to develop a scoring system for the preoperative diagnosis of hypophysitis...

Risk factors for 1-year hospital readmissions in patients with systemic lupus erythemat...
https://doi.org/10.1007/s10238-022-00835-y 10.1016/S0140-6736(19)30546-X 10.1002/ajmg.c.31696 10.1093/rheumatology 10.1007/s00296-013-2902-1 10.1002/art.24741 10.1002/art.38768 10.1186/1471-2369-15-67 10.1177/0961203308096661 10.1002/art.37795 10.3904/kjim.2016.234 10.1097/MD.0000000000000794
Clinical and Experimental Medicine; Chen J, Zhang L et. al.

May 28th, 2022 - To reveal the characteristics of and risk factors for systemic lupus erythematosus (SLE) patients with frequent readmission aiming at intervening early and improve the quality of care during initial hospitalizations. This was a single-center, retrospective case-control study involving 521 hospitalized patients with SLE from January 2014 to December 2016 in the Affiliated Hospital of Guangdong M...

Changing trends in ophthalmological emergencies during the COVID-19 pandemic.
https://doi.org/10.1371/journal.pone.0268975
PloS One; Escribano Villafruela J, de Urquía Cobo A et. al.

May 28th, 2022 - On March 11, 2020, the World Health Organization declared COVID-19-the infectious disease caused by SARS-CoV-2-a pandemic. Since then, the majority of countries-including Spain-have imposed strict restrictions in order to stop the spread of the virus and the collapse of the health systems. People's health care-seeking behavior has exhibited a change, not only in those months when the COVID-19 c...

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach
https://clinicaltrials.gov/ct2/show/NCT04685200

May 27th, 2022 - In this single-site, small-scale prospective natural history study, we intend to recruit up to 40 patients with PSC diagnosed by standard clinical, biochemical, or imaging features (including up to 30 with a known diagnosis of IBD) and up to 90 controls. Evaluation of subjects with PSC and of controls, as well as all study related procedures will take place at the National Institutes of Health ...

Real-Time Levodopa Level Monitoring in Parkinson Disease
https://clinicaltrials.gov/ct2/show/NCT04735627

May 27th, 2022 - People with Parkinson disease (PD) lack the chemical dopamine, which is important for movement. Levodopa replaces dopamine and restores normal motor function in PD. Early in the disease stages, people with PD benefit significantly from levodopa. However, as PD progresses, the brain loses more dopamine-producing cells, which causes motor complications and unpredictable responses to levodopa. To ...

Sirolimus (Rapamune ) for Relapse Prevention in People With Severe Aplastic Anemia Responsive to Immunosuppressive Therapy
https://clinicaltrials.gov/ct2/show/NCT02979873

May 27th, 2022 - Most acquired aplastic anemia ensues from immune-mediated destruction of hematopoietic stem and progenitor cells. Immunosuppression is the definitive treatment of patients with acquired aplastic anemia who are not candidates for immediate hematopoietic stem cell transplantation. Horse ATG combined with the calcineurin inhibitor, cyclosporine (CsA), remains standard as first-line immunosuppressi...

Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation Disorders
https://clinicaltrials.gov/ct2/show/NCT00895271

May 27th, 2022 - This protocol is designed as an adjunct to other National Institutes of Health (NIH) IRB approved protocols that allow for genetic testing, which may include those that are screening protocols for patients with rare primary immunodeficiency or immunodysregulation disorders. Patients deemed of sufficient research interest after review of outside medical records, clinical evaluation, and testing,...