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About 337,450 results

Surgical Treatment of Levodopa-induced Dyskinesia in Parkinson's Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586111/

The treatment of motor manifestations of Parkinson's disease (PD) is essentially a trade-off between adequate relief of motor symptoms and prevention and control of motor complications, particularly levodopa-induced dyskinesia (LID). Progression of PD is paralleled by a progressive difficulty in achieving the balance. Functional neurosurgical procedures provide sustained relief of LID in carefu...

Clinical features and multidisciplinary treatment outcome of COVID-19 pneumonia: A report of three cases
https://www.sciencedirect.com/science/article/pii/S0929664620301443

The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic threatening global public health. In the current paper, we describe our successful treatment of three COVID-19 pneumonia patients cases including severe cases and cases with mortality risk factors. One 32-year-old male COVID-19 patient was diagnosed with sev...

Safety and tolerability of IRL790 in Parkinson’s disease with levodopa-induced dyskinesia—a phase 1b trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283839/
NPJ Parkinson's Disease;

IRL790 is a novel compound with psychomotor stabilizing properties primarily targeting the dopamine D3 receptor. IRL790 is developed as an experimental treatment for levodopa-induced dyskinesia (LID), impulse control disorder, and psychosis in Parkinson’s disease (PD). The primary objective was to investigate the safety and tolerability of IRL790 in PD patients with LID in a randomized controll...

Dysfunctional inhibitory control in Parkinson’s disease patients with levodopa-induced dyskinesias
https://link.springer.com/article/10.1007/s00415-018-8945-1
Journal of Neurology;

Chronic dopamine replacement therapies in Parkinson’s disease can induce side effects, such as levodopa-induced dyskinesias and impulse control disorders. A dysfunction of inhibitory brain networks has been related to both disorders; however, there is no clear behavioral evidence supporting this hypothesis. We aimed to determine whether PD patients with levodopa-induced dyskinesias show feature...

COVID-19 and the potential long-term impact on antimicrobial resistance
https://academic.oup.com/jac/article/75/7/1681/5841159

The emergence of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has required an unprecedented response to control the spread of the infection and protect the most vulnerable within society. Whilst the pandemic has focused society on the threat of emerging infections and hand hygiene, certain infection control and antimicrobial stewardship policies may have to be relaxed. It is...

COVID-19: Operational guidance for maintaining essential health services during an outbreak
https://apps.who.int/iris/bitstream/handle/10665/331561/WHO-2019-nCoV-essential_health_services-2020.1-eng.pdf
WHO

Health systems are being confronted with rapidly increasing demand generated by the COVID-19 outbreak. When health systems are overwhelmed, both direct mortality from an outbreak and indirect mortality from vaccine-preventable and treatable conditions increase dramatically. Analyses from the 2014-2015 Ebola outbreak suggest that the increased number of deaths caused by measles, malaria, HIV/...

Advances in understanding l-DOPA-induced dyskinesia
https://www.sciencedirect.com/science/article/abs/pii/S0959438808000068?via=ihub
Current Opinion in Neurobiology;

Mar 3rd, 2008 - The crucial role of dopamine (DA) in movement control is illustrated by the spectrum of motor disorders caused by either a deficiency or a hyperactivity of dopaminergic transmission in the basal ganglia. The degeneration of nigrostriatal DA neurons in Parkinson's disease causes poverty and slowness of movement. These symptoms are greatly improved by pharmacological DA replacement with l-3,4-dih...

Guidelines for Laboratory Diagnosis of Coronavirus Disease 2019 (COVID-19) in Korea
https://www.sfndt.org/sites/www.sfndt.org/files/medias/documents/Hong et al. Ann Lab Med Avril 2020.pdf
Annals of Laboratory Medicine;

The outbreak of coronavirus disease 2019 (COVID-19), which began in December 2019, is still ongoing in Korea, with >9,000 confirmed cases as of March 25, 2020. COVID-19 is a severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection, and real-time reverse transcription-PCR is currently the most reliable diagnostic method for COVID-19 around the world. Korean Society for Laborato...

CDC Diagnostic Test for COVID-19
https://www.cdc.gov/coronavirus/2019-ncov/lab/testing.html

CDC has developed a new laboratory test kit for use in testing patient specimens for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19. The test kit is called the “Centers for Disease Control and Prevention (CDC) 2019-Novel Coronavirus (2019-nCoV) Real-Time Reverse Transcriptase (RT)-PCR Diagnostic Panel.” It is intended for use with the Applied Biosys...

Brain-Region Specific Metabolic Abnormalities in Parkinson's Disease and Levodopa-Induced Dyskinesia
https://www.frontiersin.org/articles/10.3389/fnagi.2020.00075/full
Frontiers in Aging Neuroscience;

Several lines of evidence point to alteration in brain metabolic homeostasis in Parkinson’s disease (PD) and levodopa-induced dyskinesia (LID), yet the metabolic mechanism in different brain regions underlying PD and LID remains largely unknown. The present study aimed to uncover the metabolic pathways across anatomical regions in the brain of PD and LID. Using an NMR-based metabolomic approach...

The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis
https://www.medrxiv.org/content/10.1101/2020.05.31.20114991v1.full.pdf

Respiratory failure is a key feature of severe Covid-19 and a critical driver of mortality, but for reasons poorly defined affects less than 10% of SARS-CoV-2 infected patients. Methods. We included 1,980 patients with Covid-19 respiratory failure at seven centers in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe (Milan, Monza, Madrid, San Sebastian and Barcelona) for a...

SARS-CoV-2–Associated Deaths Among Persons Aged Less Than 21 Years: United States, February 12–July 31, 2020
https://www.cdc.gov/mmwr/volumes/69/wr/mm6937e4.htm

Since February 12, 2020, approximately 6.5 million cases of SARS-CoV-2 infection, the cause of coronavirus disease 2019 (COVID-19), and 190,000 SARS-CoV-2–associated deaths have been reported in the United States (1,2). Symptoms associated with SARS-CoV-2 infection are milder in children compared with adults (3). Persons aged <21 years constitute 26% of the U.S. population (4), and this report ...

COVID-19 Control and Prevention: Healthcare Workers and Employers
https://www.osha.gov/SLTC/covid-19/healthcare-workers.html
OSHA

This section provides guidance for healthcare workers and employers. This guidance supplements the general interim guidance for workers and employers of workers at increased risk of occupational exposure to SARS-CoV-2. Employers should remain alert of changing outbreak conditions, including as they relate to community spread of the virus and testing availability, and implement infection prev...

Aerobic Exercise and Healthy Nutrition as Neuroprotective Agents for Brain Health in Patients with Parkinson’s Disease: A Critical Review of the Literature
https://www.mdpi.com/2076-3921/9/5/380/htm
Antioxidants

Parkinson’s disease (PD) is characterized by motor and nonmotor features that have an influence on patients’ quality of life at different levels. To date, some evidences have arisen on the effectiveness of physical trainings and nutrients intake in ameliorating functional and cognitive outcomes in PD patients. Physical activity is effective in improving both motor and nonmotor features and rece...

MYCAPSSA® (octreotide) Oral - Capsules Is Now FDA-Approved‎
https://hcp.mycapssa.com/

MYCAPSSA® (octreotide) delayed-release oral capsules is the first and only FDA-approved oral somatostatin analog (SSA) for appropriate patients with acromegaly, providing effective and consistent biochemical control, while freeing patients from the burden of injections.

Hypertension in rheumatic diseases: prevalence, awareness, treatment, and control rates according to current hypertension guidelines
https://www.nature.com/articles/s41371-020-0348-y
Journal of Human Hypertension; Anyfanti P

May 6th, 2020 - Hypertension is a major modifiable risk factor for cardiovascular disease. Autoimmune rheumatic diseases confer increased cardiovascular risk, which is at least partially mediated by traditional cardiovascular risk factors. We examined the prevalence, awareness, treatment, and control rates of hypertension in a large cohort of patients with rheumatic diseases.

The FDA’s Vaccines and Related Biological Products Advisory Committee and its Role in Advising the Agency on COVID-19 Vaccines
https://www.fda.gov/news-events/fda-voices/fdas-vaccines-and-related-biological-products-advisory-committee-and-its-role-advising-agency-covid

The development of safe and effective vaccines to prevent SARS-CoV-2 infection and/or COVID-19 is essential to help bring the pandemic under control. The U.S. Food and Drug Administration is committed to making decisions that are guided by science and data regarding the authorization or approval of COVID-19 vaccines.

Test sensitivity is secondary to frequency and turnaround time for COVID-19 surveillance
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325181/
Medrxiv Larremore DB, Wilder B et. al.

The COVID-19 pandemic has created a public health crisis. Because SARS-CoV-2 can spread from individuals with pre-symptomatic, symptomatic, and asymptomatic infections, the re-opening of societies and the control of virus spread will be facilitated by robust surveillance, for which virus testing will often be central.

Scientific Brief: Community Use of Cloth Masks to Control the Spread of SARS-CoV-2
https://www.cdc.gov/coronavirus/2019-ncov/more/masking-science-sars-cov2.html
Centers for Disease Control and Prevention (CDC)

SARS-CoV-2 infection is transmitted predominately by respiratory droplets generated when people cough, sneeze, sing, talk, or breathe. CDC recommends community use of masks, specifically non-valved multi-layer cloth masks, to prevent transmission of SARS-CoV-2.

Testing and Management Considerations for Nursing Home Residents with Acute Respiratory Illness Symptoms when SARS-CoV-2 and Influenza Viruses are Co-circulating
https://www.cdc.gov/flu/professionals/diagnosis/testing-management-considerations-nursinghomes.htm
Centers for Disease Control and Prevention (CDC)

The following practices should be considered when SARS-CoV-2 and Influenza viruses are found to be co-circulating based upon local public health surveillance data and testing at local healthcare facilities. While these considerations are specific to care of residents residing in nursing homes, some practices could be adapted for use in other long-term care settings (e.g. assisted living facilit...