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About 265,840 results

CDC and Texas Confirm Monkeypox In U.S. Traveler
https://www.cdc.gov/media/releases/2021/s0716-confirm-monkeypox.html
Centers for Disease Control and Prevention (CDC)

Jul 16th, 2021 - The Centers for Disease Control and Prevention (CDC) and the Texas Department of State Health Services confirmed on July 15 a case of human monkeypox in a U.S. resident who recently traveled from Nigeria to the United States. The person is currently hospitalized in Dallas. CDC is working with the airline and state and local health officials to contact airline passengers and others who may have ...

The T-type Calcium Channel Cav3.1 in Y79 Retinoblastoma Cells is Regulated by the Epide...
https://doi.org/10.1080/02713683.2021.1988982
Current Eye Research; Banderali U, Jain M et. al.

Oct 23rd, 2021 - Retinoblastoma is the most frequent intraocular cancer in children. It is also one of the most common causes for enucleation and carries a significant morbidity rate in affected individuals. Hence, studies on its pathophysiological and growth regulatory mechanisms are urgently needed to identify more effective novel therapeutics. Using the Y79 retinoblastoma cell line, we investigated the elect...

Reducing worry and rumination in young adults via a mobile phone app: study protocol of...
https://doi.org/10.1186/s12888-021-03536-0 10.1016/S0140-6736(11)60871-4 10.1001/archpsyc.62.6.593 10.1016/S0140-6736(14)61400-8 10.1016/j.jadohealth.2016.08.002 10.1007/s10964-014-0165-0 10.1017/S0033291715001725 10.1186/s12888-020-02857-w 10.1177/0963721413495872 10.1016/j.cbpra.2015.04.004 10.1001/jamapsychiatry.2017.0262 10.2196/mental.4984 10.2196/jmir.2791 10.1002/da.22654 10.1007/s11920-018-0910-2 10.1177/1754073915575406 10.1177/1754073915575404 10.1080/02699930902928969 10.1177/1754073915580601 10.1007/s10919-017-0269-9 10.1080/17439760.2015.1058968 10.1016/j.paid.2006.09.003 10.1146/annurev-clinpsy-032814-112739 10.1111/j.1758-0854.2011.01062.x 10.1521/ijct.2008.1.3.192 10.5127/jep.038813 10.1111/j.1745-6924.2008.00088.x 10.1016/j.brat.2020.103573 10.1037/0033-2909.134.2.163 10.1037/0021-843X.106.2.221 10.1023/A:1023914416469 10.1037/0022-3514.61.1.115 10.1023/A:1019873015594 10.1007/s10608-008-9191-0 10.1037/0021-843X.111.2.350 10.1037/1528-3542.1.1.25 10.1080/15374410802359627 10.1111/jcap.12102 10.1016/j.beth.2011.11.002 10.1016/j.paid.2015.06.034 10.1037/0022-3514.69.1.176 10.1016/j.beth.2006.03.003 10.1192/bjp.bp.110.090282 10.1017/S0033291711002480 10.1017/S0033291718003835 10.1016/j.brat.2016.12.015 10.2196/11349 10.1111/cpsp.12144 10.1016/j.brat.2016.09.011 10.7326/0003-4819-152-11-201006010-00232 10.1186/s13063-018-2735-z 10.2196/jmir.1923 10.1037/0022-3514.67.1.92 10.1016/0005-7967(90)90135-6 10.1046/j.1525-1497.2001.016009606.x 10.1136/jech.2011.143586.86 10.1186/1477-7525-5-63 10.1001/archinte.166.10.1092 10.1007/s10802-018-0401-2 10.1097/01.MLR.0000062554.74615.4C 10.1177/1740774512450098 10.1177/2167702615583840
BMC Psychiatry; Edge D, Newbold A et. al.

Oct 23rd, 2021 - Promoting well-being and preventing poor mental health in young people is a major global priority. Building emotional competence skills via a mobile app may be an effective, scalable and acceptable way to do this. A particular risk factor for anxiety and depression is elevated worry and rumination (repetitive negative thinking, RNT). An app designed to reduce RNT may prevent future incidence of...

Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host...
https://doi.org/10.1183/13993003.01881-2021
The European Respiratory Journal; Kulasinghe A, Tan CW et. al.

Oct 23rd, 2021 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged in late 2019 has spread globally, causing a pandemic of respiratory illness designated coronavirus disease 2019 (COVID-19). A better definition of the pulmonary host response to SARS-CoV-2 infection is required to understand viral pathogenesis and to validate putative COVID-19 biomarkers that have been proposed in cli...

GGC Repeat Expansion of NOTCH2NLC in Taiwanese Patients With Inherited Neuropathies.
https://doi.org/10.1212/WNL.0000000000013008
Neurology Liao YC, Chang FP et. al.

Oct 23rd, 2021 - The GGC repeat expansion in the 5' untranslated region of NOTCH2NLC was recently identified as the cause of neuronal intranuclear inclusion disease (NIID), which may manifest with peripheral neuropathy. The aim of this study is to investigate its contribution to inherited neuropathy. This cohort study screened patients with molecularly undiagnosed Charcot-Marie-Tooth disease (CMT) and healthy c...

Acceptability of hygiene, face covering and social distancing interventions to prevent ...
https://doi.org/10.1136/thoraxjnl-2021-217981
Thorax Hurst JR, Cumella A et. al.

Oct 23rd, 2021 - Interventions to prevent the spread of SARS-CoV-2 have been associated with substantial reductions in exacerbations of airways diseases, likely through reduced transmission of other respiratory viruses. We surveyed 4442 people with airways disease (asthma=3627, bronchiectasis=258, chronic obstructive pulmonary disease=557) to gauge attitudes and intentions towards continuing such measures after...

Sodium Butyrate Alleviates Intestinal Inflammation in Mice with Necrotizing Enterocolitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526205
Mediators of Inflammation; Sun Q, Ji YC et. al.

Oct 23rd, 2021 - To determine the role of sodium butyrate in intestinal inflammation via regulation of high-mobility group box-1 (HMGB1), we analyzed the potential mechanism in necrotizing enterocolitis (NEC) in a neonatal mouse model. A NEC model was created with hypoxia and cold exposure and artificial overfeeding. C57BL/6 neonatal mice were randomized into three groups: the control, untreated NEC, and sodium...

Intraarterial Lidocaine Administration for Pain Control by Water-in-Oil Technique in Tr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502067
Journal of Hepatocellular Carcinoma; Wang LZ, Hu XX et. al.

Oct 23rd, 2021 - To investigate the sustained release of lidocaine from a lidocaine-epirubicin-lipiodol emulsion created by water-in-oil (W/O) technique in vivo and evaluate the efficacy and safety of intraarterial lidocaine administration for intra- and postoperative pain control in transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). The in vivo concentrations of lidocaine were determine...

THE EVALUATION POTENTIAL GLOBAL IMPACT OF THE N501Y MUTATION IN SARS-COV-2 POSITIVE PAT...
https://doi.org/10.1002/jmv.27413
Journal of Medical Virology; Komurcu SZM, Artik Y et. al.

Oct 23rd, 2021 - Rapid and reliable detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations are significant to control the contagion and spread rate of the virus. We aimed to evaluate the N501Y mutation rate in randomly chosen positive patients with polymerase chain reaction (PCR). The evaluation and analysis of the data in terms of public health will contribute to the literature on ...

Performance evaluation of Elecsys SARS-CoV-2 Antigen immunoassay for diagnostic of COVI...
https://doi.org/10.1002/jmv.27412
Journal of Medical Virology; Montalvo Villalba MC, Sosa Glaria E et. al.

Oct 23rd, 2021 - One of challenge for control and prevention of SARS-CoV-2 infection is the early diagnostic at the point of care. Several tests based on qualitative antigen detection have been developed; one of these is Elecsys SARS-CoV-2 Antigen immunoassay (Roche Diagnostics). In total 523 nasopharyngeal swabs were randomly selected with the aims to evaluate sensitivity, specificity, cross-reactivity, positi...

Video game therapy on mobility and dual tasking in multiple sclerosis: study protocol f...
https://doi.org/10.1136/bmjopen-2021-052005
BMJ Open; Baroni A, Fregna G et. al.

Oct 23rd, 2021 - Multiple sclerosis (MS) is one of the major causes of disability in young adults and affects mobility, compromising daily living activities and participation in social life. Cognitive domain is also frequently impaired in people with MS (PwMS), particularly the capacity to perform dual-task activities. Impaired cognitive processing abilities need to be treated, and motor and cognitive aspects n...

Leveraging immune memory against measles virus as an antitumor strategy in a preclinica...
https://doi.org/10.1136/jitc-2020-002170
Journal for Immunotherapy of Cancer; Leb-Reichl VM, Kienzl M et. al.

Oct 23rd, 2021 - Viral antigens are among the strongest elicitors of immune responses. A significant proportion of the human population already carries pre-existing immunity against several childhood viruses, which could potentially be leveraged to fight cancer. We sought to provide proof of concept in mouse models that a pre-existing measles virus (MeV) immunity can be redirected to inhibit tumor growth by dir...

Intracellular delivery of protein drugs with an autonomously lysing bacterial system re...
https://doi.org/10.1038/s41467-021-26367-9 10.1126/science.1260419 10.1016/j.cell.2011.02.013 10.3390/molecules24050927 10.1093/annonc/mdh097 10.1016/j.addr.2015.12.002 10.2174/1567201813666160713121122 10.1038/nnano.2007.387 10.4161/mabs.22854 10.1038/nrc3236 10.1016/j.jconrel.2017.02.006 10.1007/s00018-009-0053-z 10.1039/C6CS00636A 10.1016/j.addr.2011.04.006 10.1126/science.1090124 10.1016/j.cell.2006.02.012 10.1038/cgt.2011.10 10.1038/sj.bjc.6605403 10.1093/emboj/19.13.3235 10.1099/mic.0.032896-0 10.1073/pnas.1006098107 10.1371/journal.ppat.1006925 10.1016/j.chom.2017.02.005 10.1371/journal.ppat.1004374 10.1111/j.1600-0854.2008.00821.x 10.1146/annurev.cellbio.17.1.53 10.1016/j.chom.2013.07.010 10.3389/fcimb.2017.00335 10.1186/s40425-018-0490-z 10.1128/IAI.00468-15 10.1371/journal.ppat.1002810 10.1016/j.mib.2014.09.019 10.1128/JB.183.9.2733-2745.2001 10.1016/j.mib.2005.12.006 10.1038/nmeth.1437 10.1038/nature05272 10.1128/IAI.00052-07 10.1128/jb.176.23.7345-7351.1994 10.1128/JB.00635-10 10.1371/journal.ppat.1003987 10.1586/erv.13.7 10.1038/5205 10.2174/156652310790945575 10.1073/pnas.0408422102 10.1074/jbc.M008363200 10.1073/pnas.0707715105 10.1093/emboj/19.13.3235 10.1046/j.1365-2958.2002.02912.x 10.1039/c2ib00091a 10.1080/2162402X.2017.1382791 10.1128/IAI.67.9.4499-4509.1999 10.1038/ncb1292 10.1111/j.1462-5822.2006.00706.x 10.1034/j.1600-0854.2003.00118.x 10.3322/caac.21149 10.3748/wjg.v20.i15.4115 10.2165/00003495-200969020-00006 10.1055/s-2007-963285 10.1534/genetics.110.120782 10.1016/j.jmb.2005.11.020 10.1073/pnas.1414558112 10.1016/j.jmb.2010.11.031 10.1039/B810571E
Nature Communications; Raman V, Van Dessel N et. al.

Oct 23rd, 2021 - Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell membranes. Here we report the development of a Salmonella-based intracellular delivery system to address this challenge. We engineer genetic circuits that (1) activate the regulator flhDC to drive invasion and (2) induce lysis to release proteins into tumor cells. Released protein drugs diffuse from Sa...

Proteomic analysis of the host-pathogen interface in experimental cholera.
https://doi.org/10.1038/s41589-021-00894-4 10.1038/nmeth.1714 10.1016/j.cell.2014.04.028 10.1038/s41467-019-12672-x 10.1128/mr.47.4.510-550.1983 10.1016/S0140-6736(17)30559-7 10.3390/toxins2030310 10.1038/1831533a0 10.1128/mBio.00047-10 10.1084/jem.168.4.1487 10.1016/j.chom.2011.07.007 10.1016/j.chom.2013.11.001 10.1371/journal.pgen.1004782 10.1371/journal.ppat.1003800 10.1128/IAI.00585-08 10.1073/pnas.1403683111 10.1038/nchembio.2025 10.1056/NEJMoa1012928 10.1038/s41586-019-1453-3 10.1371/journal.pone.0007352 10.1021/pr201135e 10.1038/nmeth745 10.3389/fmicb.2019.02057 10.1002/pro.2815 10.1046/j.1365-2958.2001.02683.x 10.1016/0378-1119(95)00054-A 10.1073/pnas.1712837114 10.1165/rcmb.2005-0462OC 10.1165/ajrcmb.24.4.3504 10.1016/j.jsb.2016.06.019 10.1128/IAI.72.2.709-716.2004 10.3389/fimmu.2012.00354 10.3390/ijms19041045 10.1007/s12275-018-7545-1 10.1016/j.redox.2020.101524 10.1016/S1534-5807(03)00090-X 10.1126/science.283.5409.1914 10.1038/cmi.2014.105 10.1038/nchembio.1525 10.1093/femsre/fuv008 10.1016/j.cell.2014.08.006 10.1172/JCI117323 10.3389/fcimb.2020.00229 10.1038/nmicrobiol.2016.125 10.1073/pnas.1431769100 10.1038/nsmb.3053 10.1038/nbt.2839 10.1371/journal.ppat.1009290 10.21769/BioProtoc.1455 10.1038/s41587-019-0209-9 10.1038/nmeth.3869 10.1371/journal.pone.0067019 10.1093/nar/30.1.207
Nature Chemical Biology; Zoued A, Zhang H et. al.

Oct 23rd, 2021 - The microbial cell surface is a site of critical microbe-host interactions that often control infection outcomes. Defining the set of host proteins present at this interface has been challenging. Here we used a surface-biotinylation approach coupled to quantitative mass spectrometry to identify and quantify both bacterial and host proteins present on the surface of diarrheal fluid-derived Vibri...

Racial and ethnic differences in all-cause mortality among Hispanics diagnosed with fol...
https://doi.org/10.1007/s10552-021-01507-0 10.1182/blood-2016-01-643569 10.1002/ajh.25696 10.1002/ajh.25595 10.1016/j.canep.2014.12.001 10.1080/10428194.2020.1839656 10.1182/blood-2011-01-293050 10.1182/asheducation-2009.1.523 10.1056/NEJM200107123450205 10.1182/blood-2003-12-4434 10.1182/blood.V46.2.219.219 10.1016/S1470-2045(16)30029-8 10.1136/bmj.332.7549.1080 10.1002/cncr.27513 10.1016/j.clml.2011.07.002 10.1182/blood-2013-07-517110 10.1093/aje/kwp383 10.1038/ng.419 10.1016/j.celrep.2013.12.027 10.1016/S0140-6736(10)62175-7 10.1056/NEJMoa1805104 10.1007/s10552-015-0609-1 10.1016/j.hoc.2020.02.001 10.1093/jncimonographs/lgu001 10.1016/j.jclinepi.2018.11.024 10.2478/s13382-011-0037-8 10.1002/ijc.33164 10.1111/bjh.12512 10.1370/afm.1279 10.1007/s40615-019-00660-2
Cancer Causes & Control : CCC; Blansky D, Fazzari M et. al.

Oct 23rd, 2021 - Research suggests better survival among Hispanics with diffuse large B-cell lymphoma (DLBCL) compared to non-Hispanic Whites (NHW); however, less is known about racial/ethnic survival differences in follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL). We identified incident FL and CLL cases diagnosed between 2005 and 2016 at Montefiore Medical Center in the Bronx, NY. Cox proportion...

Longitudinal Stability of Intellectual Functioning in Autism Spectrum Disorder: From Ag...
https://doi.org/10.1007/s10803-021-05227-x 10.1109/TAC.1974.1100705 10.1080/09297040500473714 10.1016/j.neuroimage.2006.08.032 10.1111/jcpp.12178 10.1093/brain/awr263 10.1037/neu0000418 10.1176/appi.ajp.2017.16101115 10.1007/s10803-014-2250-3 10.1352/1944-7558-116.5.331 10.1080/09297040600630288 10.1016/j.rasd.2016.11.013 10.1073/pnas.1718793115 10.1093/arclin/acw079 10.1037/pas0000358 10.1186/s13229-017-0145-9 10.1017/S0033291710000991 10.1146/annurev-psych-120710-100353 10.1023/a:1022903913547 10.1080/13803395.2013.827156 10.1002/aur.69 10.1097/00004583-199105000-00003 10.5962/bhl.title.61710 10.1080/09297049.2015.1056131 10.1093/cercor/bhy330 10.1016/j.neuron.2012.06.022 10.1177/0956797614567339 10.1093/arclin/acw064 10.1111/j.1469-7610.2004.00215.x 10.1016/j.jaac.2013.02.017 10.1111/jcpp.12115 10.1007/s10803-012-1719-1 10.1007/s10803-014-2080-3 10.2466/03.15.PR0.116k24w8 10.1111/1469-7610.00092 10.1177/0022219410392044 10.3390/jintelligence6040045 10.1001/jamanetworkopen.2018.4777 10.1007/s10803-017-3213-2 10.1002/ajmg.a.31465 10.2307/2529876 10.1080/87565641003696833 10.1080/01621459.1989.10478761 10.1002/aur.1427 10.1002/ajmg.c.31440 10.1177/1362361320919246 10.1007/BF02172145 10.1080/13803390802169059 10.1016/j.cpr.2013.11.002 10.1016/j.pscychresns.2018.06.013 10.33588/rn.66S01.2018011 10.1177/1362361303007001006 10.1007/s10882-011-9231-7 10.1002/aur.1366 10.1002/aur.1909 10.1002/aur.2084 10.1111/j.1600-0447.1998.tb09970.x 10.1002/aur.1910 10.1111/jcpp.13180 10.1002/aur.1265 10.3390/jintelligence5020018 10.1037/dev0000162 10.1177/1073191117721742 10.1037/pag000028 10.1016/j.jaac.2019.11.020 10.1002/aur.1884 10.1037/a0024935 10.1111/jir.12423 10.1002/aur.2081 10.1111/desc.12401 10.1016/j.neuropsychologia.2013.11.008 10.1186/s13229-015-0001-8 10.1016/j.ridd.2014.02.013 10.1017/s0954579498001667 10.1111/j.2041-210X.2011.00125.x 10.1371/journal.pone.0049172 10.1093/brain/awu083
Journal of Autism and Developmental Disorders; Prigge MBD, Bigler ED et. al.

Oct 23rd, 2021 - Intelligence (IQ) scores are used in educational and vocational planning for individuals with autism spectrum disorder (ASD) yet little is known about the stability of IQ throughout development. We examined longitudinal age-related IQ stability in 119 individuals with ASD (3-36 years of age at first visit) and 128 typically developing controls. Intelligence measures were collected over a 20-yea...

Pretreatment Neutrophil-to-Lymphocyte Ratio as a Predictive Marker of Response to Atezo...
https://doi.org/10.3390/curroncol28050352
Current Oncology (Toronto, Ont.); Eso Y, Takeda H et. al.

Oct 23rd, 2021 - Combination therapy with anti-programmed death-ligand 1 monoclonal antibody atezolizumab plus anti-vascular endothelial growth factor agent bevacizumab (Atezo/Bev) was approved in 2020 as a first-line treatment for unresectable hepatocellular carcinoma (HCC). Atezo/Bev therapy is relatively well tolerated; however, factors that can predict its response have not yet been reported. Thus, we aimed...

Immune Checkpoint Inhibitors for Advanced Cutaneous Squamous Cell Carcinoma: A Systemat...
https://doi.org/10.1007/s11523-021-00844-z 10.1016/j.jaad.2012.11.037 10.1111/j.1365-2133.2012.10830.x 10.1016/j.jaad.2017.08.059 10.1136/bmj.f6153 10.1016/0190-9622(92)70144-5 10.1016/S0360-3016(01)01656-X 10.1016/j.jaad.2017.07.048 10.1200/JCO.2010.34.1735 10.1002/cncr.31346 10.1097/DSS.0000000000000799 10.1097/COC.0000000000000088 10.1200/JCO.2019.37.15_suppl.e21033 10.1158/1535-7163.MCT-16-0665 10.1097/EDE.0b013e3181fe7825 10.1136/bmj.315.7109.629 10.1016/S0895-4356(01)00377-8 10.1056/NEJMoa1805131 10.1200/JCO.19.03054 10.1200/JCO.19.03357 10.1016/S1470-2045(19)30728-4 10.1136/jitc-2020-000775 10.1200/JCO.2019.37.15_suppl.e21015 10.1016/j.ejca.2020.01.008 10.1007/s11864-016-0408-2 10.1016/j.ejca.2020.07.029 10.3390/cancers13143547 10.1016/j.jgo.2021.02.026 10.1111/cup.13709 10.1186/s13073-017-0424-2 10.1007/s40265-020-01302-2 10.3747/co.27.6015 10.1200/JCO.2020.38.15_suppl.TPS10084 10.1200/JCO.2019.37.15_suppl.TPS9597 10.1093/annonc/mdz394.071 10.1016/j.ejca.2008.10.026 10.1002/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6 10.1136/jitc-2019-000146
Targeted Oncology; Mehta NK, Li AR et. al.

Oct 23rd, 2021 - Results of early trials led to FDA approval of immune checkpoint inhibitors (ICIs) for advanced and recurrent/metastatic (R/M) cutaneous squamous cell carcinoma (CSCC). Updated data from these trials are pending and extent of survival outcomes is undetermined. The aim of this study was to assess the efficacy of ICIs in advanced CSCC, comprising locally advanced (LA), locoregionally advanced (LR...

Nosocomial cluster of carbapenemase-producing Enterobacter cloacae in an intensive care...
https://doi.org/10.1186/s13756-021-01022-6 10.1016/S0140-6736(20)30154-9 10.1016/S1473-3099(18)30605-4 10.1186/s13756-020-0703-3 10.1128/AAC.50.4.1282-1286.2006 10.1093/jac/dkaa345 10.1371/journal.pone.0135044 10.1016/j.meegid.2017.07.019 10.1093/jac/dky257 10.1128/CMR.00115-18 10.1093/jacamr/dlab032 10.1186/s13756-020-00820-8
Antimicrobial Resistance and Infection Control; Miltgen G, Garrigos T et. al.

Oct 23rd, 2021 - Concomitant prevention of SARS-CoV-2 and extensively drug-resistant bacteria transmission is a difficult challenge in intensive care units dedicated to COVID-19 patients. We report a nosocomial cluster of four patients carrying NDM-1 plasmid-encoded carbapenemase-producing Enterobacter cloacae. Two main factors may have contributed to cross-transmission: misuse of gloves and absence of change o...

Vestibular functions in patients with idiopathic sudden sensorineural hearing loss and ...
https://doi.org/10.1016/j.anl.2021.09.009
Auris, Nasus, Larynx; Kizkapan DB, Karlidag T et. al.

Oct 23rd, 2021 - Because of the anatomically close relationship between the cochlea and the vestibular organs, cochlear function disorders may be accompanied by vestibular disorders. This study aimed to evaluate vestibular functions in patients with idiopathic sudden sensorineural hearing loss using VEMP, caloric test, and VNG test battery and its relation to prognosis. For this study, 42 patients aged 18-55 ye...