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About 386,870 results

Concomitant disease should be considered when treating progressive glaucoma
https://www.healio.com/news/ophthalmology/20220120/concomitant-disease-should-be-considered-when-treating-progressive-glaucoma

Jan 20th, 2022 - WAIKOLOA, Hawaii — Ophthalmologists should consider co-management of other diseases when treating progressive glaucoma, according to a speaker here. “I think that we need to remind ourselves, even as we rush through clinic, to think about the linkage to common disease that puts the optic nerve at risk,” Jeffrey L. Goldberg, MD, PhD, said at Hawaiian Eye 2022. To aid with co-management, he said,...

Several pathways under investigation for dry AMD treatment
https://www.healio.com/news/ophthalmology/20220118/several-pathways-under-investigation-for-dry-amd-treatment

Jan 18th, 2022 - WAIKOLOA, Hawaii — Several pathways are under investigation for the treatment of dry age-related macular degeneration, according to a presentation at Retina 2022. “The big issue for us researchers is we don’t have a good animal model to test anything,” Peter K. Kaiser, MD, said. “We don’t have preclinical models that inform us if a drug is going to work or not because the animal that we use are...

High resolution dermal ultrasound (US) combined with superficial radiation therapy (SRT...
https://doi.org/10.1186/s12885-023-10577-z
BMC Cancer; Yu L, Moloney M et. al.

Jan 29th, 2023 - To compare the effectiveness of high-resolution dermal ultrasound (US) guided superficial radiotherapy (SRT) to non-image-guided radiotherapy in the treatment of early-stage Non-Melanoma Skin Cancer (NMSC). A high-resolution dermal ultrasound (US) image guided form of superficial radiation therapy (designated here as US-SRT) was developed in 2013 where the tumor configuration and depth can be v...

PRKN/parkin-mediated mitophagy is induced by the probiotics Saccharomyces boulardii and...
https://doi.org/10.1080/15548627.2023.2172873
Autophagy Hawrysh PJ, Gao J et. al.

Jan 29th, 2023 - Mitochondrial impairment is a hallmark feature of neurodegenerative disorders, such as Parkinson disease, and PRKN/parkin-mediated mitophagy serves to remove unhealthy mitochondria from cells. Notably, probiotics are used to alleviate several symptoms of Parkinson disease including impaired locomotion and neurodegeneration in preclinical studies and constipation in clinical trials. There is som...

Development and validation of a model for predicting the adult height of girls with idi...
https://doi.org/10.1007/s00431-023-04842-3
European Journal of Pediatrics; Wu W, Zhu X et. al.

Jan 29th, 2023 - The aim was to develop a model to predict the adult height (AH) of idiopathic central precocious puberty (ICPP) girls who underwent gonadotropin-releasing hormone analog (GnRHa) treatment. Data analysis included 258 girls with ICPP. Among them, 101 girls who reached final AH (FAH) with GnRHa treatment were analyzed to verify three previous prediction models and develop a unique model based on m...

Epidemiology, course, and outcomes of Sars-CoV-2 infection in patients with acromegaly ...
https://doi.org/10.1007/s40618-023-02016-4
Journal of Endocrinological Investigation; Ragonese M, Giuffrida G et. al.

Jan 29th, 2023 - Acromegaly (AC) and Cushing's disease (CD) increase morbidity and mortality due to cardio-metabolic alterations, and overall cause frailty in the affected patients, potentially making them more susceptible to infective diseases. However, up to now, very few studies evaluated the course of COVID-19 disease in this setting. We investigated epidemiology, course, and outcomes of COVID-19 disease in...

Lipid biomarkers that reflect postoperative recurrence risk in lung cancer patients who...
https://doi.org/10.1186/s12944-023-01778-3
Lipids in Health and Disease; Takanashi Y, Kahyo T et. al.

Jan 29th, 2023 - The risk of postoperative recurrence is higher in lung cancer patients who smoke than non-smokers. However, objective evaluation of the postoperative recurrence risk is difficult using conventional pathological prognostic factors because of their lack of reproducibility. Consequently, novel objective biomarkers that reflect postoperative risk in lung cancer patients who smoke must be identified...

Meta-analysis: The impact of light-to-moderate alcohol consumption on progressive non-a...
https://doi.org/10.1111/apt.17388
Alimentary Pharmacology & Therapeutics; Magherman L, Van Parys R et. al.

Jan 29th, 2023 - Non-alcoholic fatty liver disease (NAFLD) is defined as fatty liver disease in the absence of heavy alcohol consumption. However, the impact of light-to-moderate alcohol consumption on progressive NAFLD and on mortality is presently unclear. Medline, Embase, OATD and OpenGrey were systematically searched up to November 2022 for relevant cross-sectional, case-control and cohort studies. The stud...

Sexual dysfunction in women with interstitial cystitis/bladder pain syndrome: Do onabot...
https://doi.org/10.1002/nau.25139
Neurourology and Urodynamics; Topcuoglu M, Karaburun MC et. al.

Jan 29th, 2023 - Interstitial cystitis/bladder pain syndrome (IC/BPS) has a negative impact on female sexual function. We aimed to evaluate the effect of intravesical botulinum toxin-A (BTX-A) injection on the improvement of sexual dysfunction and urinary symptoms using the multi-domain female sexual function Index (FSFI), interstitial cystitis symptom index (ICSI), and interstitial cystitis problem index (ICPI...

Multicentric Italian case-control study on 25OH vitamin D levels in children and adoles...
https://doi.org/10.1007/s40618-022-01990-5
Journal of Endocrinological Investigation; Panfili FM, Convertino A et. al.

Jan 29th, 2023 - 25OHD levels in patients with Prader-Willi Syndrome (PWS), the most frequent cause of genetic obesity with a peculiar fat mass distribution, are still debated. Insulin resistance (IR), Body Mass Index-SDS (BMI-SDS), Growth Hormone Therapy (GHT), and puberty onset seem to interact with 25OHD levels. The objectives of the study are: (1) To analyze 25OHD levels in pediatric PWS patients in compari...

DNA methylation and transcriptome signatures of the PDCD1 gene in ankylosing spondylitis.
https://doi.org/10.1038/s41435-023-00196-w
Genes and Immunity; Wu Y, Chen Y et. al.

Jan 29th, 2023 - Ankylosing spondylitis (AS) is an autoimmune-related inflammatory arthritis. The association between the DNA methylation and mRNA expression of PDCD1 gene with the susceptibility to AS remains unclear. In this case-control study, the methylation level of PDCD1 promoter was detected in 80 AS patients and 80 healthy controls by MethylTarget method. The transcriptional level of PDCD1 gene was meas...

A CIRCULATION-FIRST APPROACH FOR RESUSCITATION OF TRAUMA PATIENTS WITH HEMORRHAGIC SHOCK.
https://doi.org/10.1097/SHK.0000000000002028
Shock (Augusta, Ga.); Chio JCT, Piehl M et. al.

Jan 28th, 2023 - The original guidelines of cardiopulmonary resuscitation focused on the establishment of an airway and rescue breathing before restoration of circulation through cardiopulmonary resuscitation. As a result, the airway-breathing-circulation approach became the central guiding principle of resuscitation. Despite new guidelines by the American Heart Association for a circulation-first approach, Adv...

PROGRESSION OF VASCULAR FUNCTION AND BLOOD PRESSURE IN A MOUSE MODEL OF KAWASAKI DISEASE.
https://doi.org/10.1097/SHK.0000000000002026
Shock (Augusta, Ga.); DelVechio M, Alves JV et. al.

Jan 28th, 2023 - Kawasaki disease (KD) is a systemic vasculitis of childhood characterized by vascular damage in the acute stage, which can persist into the late stage. The vascular mechanisms in the cardiovascular risk of KD are not fully studied. We investigated the vascular function and blood pressure in a murine model of KD. We used the Candida albicans water-soluble (CAWS) fraction model. Mice were injecte...

Herpetic Eye Disease After SARS-CoV-2 Vaccination: A CDC-VAERS Database Analysis.
https://doi.org/10.1097/ICO.0000000000003246
Cornea Singh RB, Parmar UPS et. al.

Jan 28th, 2023 - The aim of this study was to evaluate the cases of herpes simplex and zoster ophthalmicus after SARS-CoV-2 vaccination and assess the clinical presentations in patients. A retrospective analysis of cases reported to the Centers for Disease Control and Prevention (CDC) Vaccine Adverse Event Reporting System (VAERS) between December 11, 2020, and July 1, 2022. Patients diagnosed with herpes simpl...

Severe Recurrent Nocturnal Hypoglycemia During Chemotherapy With 6-mercaptopurine in 2 ...
https://doi.org/10.1097/MPH.0000000000002609
Journal of Pediatric Hematology/oncology; Albiroty K, Al Sabahi A

Jan 28th, 2023 - Mercaptopurine (6MP) and methotrexate are the cornerstones of maintenance therapy in pediatric patients with acute lymphoblastic leukemia. However, although bone marrow suppression and liver dysfunction are common side effects of these antimetabolites, 6MP-induced hypoglycemia during the maintenance phase is rare. Guidelines and international protocols are well established for the management of...

Nutritional status and eating behavior of children with autism spectrum disorders in Vi...
https://doi.org/10.1177/02601060231152278
Nutrition and Health; Trinh NB, Phan NDT et. al.

Jan 28th, 2023 - Background: Atypical eating behaviors and feeding issues are common in children with autism spectrum disorder (ASD). Aim: This study aims to evaluate the nutritional status and eating behavior of the ASD and typically developing groups. Methods: A case-control study was conducted from January to April 2019 in Nghe An, Vietnam. A total of 93 children in each group participated in the study with ...

Systematic review and synthesis of stillbirths and late miscarriages following SARS-CoV...
https://doi.org/10.1016/j.ajog.2023.01.019
American Journal of Obstetrics and Gynecology; Alcover N, Regiroli G et. al.

Jan 28th, 2023 - To describe the characteristics of fetal demises following SARS-CoV-2 infections and clarify if they are associated with clinical severity, placental lesions or malformations or due to actual fetal infections. PubMed and Web of Science databases (searched between December 1, 2019 and April 30, 2022). Cohort, cross-sectional and case-control studies, as well as case series or case reports descri...

Gymnadenia conopsea (L.) R. Br.: Comprehensive review of propagation and breeding, trad...
https://doi.org/10.1016/j.jep.2023.116205
Journal of Ethnopharmacology; Meng XH, Wang M et. al.

Jan 28th, 2023 - Gymnadenia conopsea, a perennial herbaceous flowering plant that belongs to the family of Orchidaceae, sporadic distributed in the altitudes of 200-4700 m across northern Europe and, temperate and subtropical Asia region. The dried tubers of G. conopsea have been used to treat cough, asthma, and their syndromes, and also as a tonic in China and surrounding countries for a long history. G. conop...

The outcomes of combined endoscopic surgery and fibrinolytic treatment protocol for int...
https://doi.org/10.1016/j.wneu.2023.01.080
World Neurosurgery; Noiphithak R, Ratanavinitkul W et. al.

Jan 28th, 2023 - Intraventricular fibrinolysis (IVF) and endoscopic surgery (ES) are the new promising treatment strategies to enhance the rate of hematoma clearance which might improve functional outcome. This study investigated and compared the outcomes among these interventions. A randomized (1:1) double-blinded trial was carried out between August 2018 and December 2021. The intervention and control groups ...

Membranous nephropathy after a recent SARS-CoV-2 infection.
https://doi.org/10.1136/bcr-2022-252468
BMJ Case Reports; Mateus C, Theias Manso R et. al.

Jan 28th, 2023 - SARS-CoV-2 infections can induce kidney injury and glomerulopathy, with the most common pathology findings being acute tubular injury and collapsing glomerulopathy.Here we describe a rare case of membranous nephropathy in a man in his late 70s presented with nephrotic syndrome and rapidly progressive kidney dysfunction 1 month after SARS-CoV-2 infection. Phospholipase A2 receptor antibodies wer...