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About 49,796 results

Contributions of the social environment to first-onset and recurrent mania.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206672
Molecular Psychiatry; Gilman SE, Ni MY et. al.

Apr 22nd, 2014 - In treated cohorts, individuals with bipolar disorder are more likely to report childhood adversities and recent stressors than individuals without bipolar disorder; similarly, in registry-based studies, childhood adversities are more common among individuals who later become hospitalized for bipolar disorder. Because these types of studies rely on treatment-seeking samples or hospital diagnose...

Multicenter pilot treatment trial for psychogenic nonepileptic seizures: a randomized c...
https://doi.org/10.1001/jamapsychiatry.2014.817
JAMA Psychiatry; LaFrance WC, Baird GL et. al.

Jul 5th, 2014 - There is a paucity of controlled treatment trials for the treatment of conversion disorder, seizures type, also known as psychogenic nonepileptic seizures (PNES). Psychogenic nonepileptic seizures, the most common conversion disorder, are as disabling as epilepsy and are not adequately addressed or treated by mental health clinicians. To evaluate different PNES treatments compared with standard...

Treatment-free remission following frontline nilotinib in patients with chronic myeloid...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508077
Leukemia Hochhaus A, Masszi T et. al.

Feb 21st, 2017 - The single-arm, phase 2 ENESTfreedom trial assessed the potential for treatment-free remission (TFR; i.e., the ability to maintain a molecular response after stopping therapy) following frontline nilotinib treatment. Patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase with MR4.5 (BCR-ABL1⩽0.0032% on the International Scale (BCR-ABL1IS)) and ⩾2 years of front...

Beneficial effects of growth hormone treatment on cognition in children with Prader-Wil...
https://doi.org/10.1210/jc.2012-1182
The Journal of Clinical Endocrinology and Metabolism; Siemensma EP, Tummers-de Lind van Wijngaarden RF et. al.

Apr 17th, 2012 - Knowledge about the effects of GH treatment on cognitive functioning in children with Prader-Willi syndrome (PWS) is limited. Fifty prepubertal children aged 3.5 to 14 yr were studied in a randomized controlled GH trial during 2 yr, followed by a longitudinal study during 4 yr of GH treatment. Cognitive functioning was measured biennially by short forms of the WPPSI-R or WISC-R, depending on ag...

The impact of comorbid posttraumatic stress disorder on bipolar disorder patients.
https://doi.org/10.1016/j.jad.2009.08.005
Journal of Affective Disorders; Quarantini LC, Miranda-Scippa A et. al.

Sep 7th, 2009 - Available data regarding posttraumatic stress disorder (PTSD) in bipolar disorder (BD) are scarce and usually from a limited sample size. The present report was carried out using the Brazilian Research Consortium for Bipolar Disorders and aimed to examine whether patients with BD and comorbid PTSD are at an increased risk for worse clinical outcomes. A consecutive sample of bipolar I outpatient...

Impact of human papillomavirus-related genital diseases on quality of life and psychoso...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225724
BMC Public Health; Dominiak-Felden G, Cohet C et. al.

Nov 12th, 2013 - Data on the psychosocial burden of human papillomavirus (HPV)-related diseases other than cervical cancer are scarce. The objectives of this study were to measure and compare the psychosocial burden and the impact on health-related quality of life (HRQoL) of HPV-related lower genital tract diseases and genital warts (GW) using several generic and disease-specific instruments. Overall, 842 indiv...

Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315021
The Lancet. Neurology; Byrne S, Elamin M et. al.

Feb 6th, 2012 - Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of upper and lower motor neurons, associated with frontotemporal dementia (FTD) in about 14% of incident cases. We assessed the frequency of the recently identified C9orf72 repeat expansion in familial and apparently sporadic cases of ALS and characterised the cognitive and clinical phenotype of patients with this ex...

Xp22.3 genomic deletions involving the CDKL5 gene in girls with early onset epileptic e...
https://doi.org/10.1111/j.1528-1167.2009.02308.x
Epilepsia Mei D, Marini C et. al.

Sep 28th, 2009 - Mutations of the X-linked gene cyclin-dependent kinase-like 5 (CDKL5) cause an X-linked encephalopathy with early onset intractable epilepsy, including infantile spasms and other seizure types, and a Rett syndrome (RTT)-like phenotype. Very limited information is available on the frequency and phenotypic spectrum associated with CDKL5 deletions/duplications. We investigated the role of CDKL5 de...

Functional weakness: clues to mechanism from the nature of onset.
https://doi.org/10.1136/jnnp-2011-300125
Journal of Neurology, Neurosurgery, and Psychiatry; Stone J, Warlow C et. al.

Aug 12th, 2011 - Functional weakness describes weakness which is inconsistent and incongruent with disease. It is also referred to as motor conversion disorder (DSM-IV), dissociative motor disorder (ICD-10) and 'psychogenic' paralysis. Studies of aetiology have focused on risk factors such as childhood adversity and life events; information on the nature and circumstance of symptom onset may shed light on the m...

Investigating factors associated with adherence behaviour in patients with chronic myel...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464760
British Journal of Cancer; Efficace F, Baccarani M et. al.

Aug 8th, 2012 - Optimal adherence to imatinib therapy is of paramount importance to maximise treatment effectiveness in patients with chronic myeloid leukaemia (CML). The main objective of this study was to investigate patient-reported personal factors associated with adherence behaviour. Analysis was conducted on 413 CML patients receiving long-term therapy with imatinib. Adherence behaviour was measured with...

Validity of the aberrant behavior checklist in children with autism spectrum disorder.
https://doi.org/10.1007/s10803-013-1970-0
Journal of Autism and Developmental Disorders; Kaat AJ, Lecavalier L et. al.

Oct 29th, 2013 - The Aberrant Behavior Checklist (ABC) is a widely used measure in autism spectrum disorder (ASD) treatment studies. We conducted confirmatory and exploratory factor analyses of the ABC in 1,893 children evaluated as part of the Autism Treatment Network. The root mean square error of approximation was .086 for the standard item assignment, and in exploratory factor analysis, the large majority o...

Low compliance to pharmacological treatment is linked to cognitive impairment in euthym...
https://doi.org/10.1016/j.jad.2016.02.005
Journal of Affective Disorders; Fuentes I, Rizo-Méndez A et. al.

Feb 21st, 2016 - Cognitive impairment and low compliance to pharmacological treatment are frequent complications in bipolar disorder. Moreover, low compliance in patients with bipolar disorder is one of the main reasons for relapse. This in turn, is associated with an increase in neurocognitive symptoms. The current study aimed to determine whether attention, memory, and executive function are related to the le...

Pediatric case study and review: is it a conversion disorder?
https://doi.org/10.2190/PM.38.2.e
International Journal of Psychiatry in Medicine; Spratt EG, Thomas SG

Aug 29th, 2008 - It is common in health care settings for adolescent patients to report physical symptoms that are unexplained by physical disease or pathophysiologic processes. The diagnosis of conversion disorder is difficult to make as many of these patients present to primary care with complex, difficult-to-understand medical symptoms. Patients can present with a medical dilemma and a symptom model consiste...

Quality of life in pediatric bipolar disorder.
https://doi.org/10.1542/peds.2008-0841
Pediatrics Freeman AJ, Youngstrom EA et. al.

Mar 3rd, 2009 - Bipolar disorder is a common mood disorder associated with significant disability and impairment in quality of life in adults. Little research has examined the impact of the disorder on quality of life in children and adolescents. The current study examines the quality of life in children and adolescents with bipolar disorder compared with other physical and psychiatric illnesses. This study in...

Biochemical correlates of neuropsychiatric illness in maple syrup urine disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613932
The Journal of Clinical Investigation; Muelly ER, Moore GJ et. al.

Mar 12th, 2013 - Maple syrup urine disease (MSUD) is an inherited disorder of branched chain amino acid metabolism presenting with neonatal encephalopathy, episodic metabolic decompensation, and chronic amino acid imbalances. Dietary management enables survival and reduces risk of acute crises. Liver transplantation has emerged as an effective way to eliminate acute decompensation risk. Psychiatric illness is a...

Long-term outcomes after allogeneic hematopoietic stem cell transplantation for metachr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545855
Orphanet Journal of Rare Diseases; Boucher AA, Miller W et. al.

Aug 7th, 2015 - Metachromatic Leukodystrophy (MLD) is a rare, fatal demyelinating disorder with limited treatment options. Published outcomes after hematopoietic stem cell transplantation (HSCT) are scant and mixed. We report survival and function following HSCT for a large, single-center MLD cohort. Transplant-related data, survival and serial measures (brain MRI, nerve conduction velocity (NCV), neurologic a...

Psychosocial Characteristics of Children with Central Disorders of Hypersomnolence Vers...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623126
Journal of Clinical Sleep Medicine : JCSM : Official Publ... Avis KT, Shen J et. al.

Aug 18th, 2015 - Hypersomnia of central origin from narcolepsy or idiopathic hypersomnia (IHS) is characterized by pathological levels of excessive daytime sleepiness (EDS). Central hypersomnia has historically been underdiagnosed and poorly understood, especially with respect to its impact on daytime functioning and quality of life in children. Describe the psychosocial adjustment of children treated for narco...

Restless legs syndrome in children with chronic kidney disease.
https://doi.org/10.1007/s00467-013-2408-9
Pediatric Nephrology (Berlin, Germany); Riar SK, Leu RM et. al.

Jan 21st, 2013 - Restless legs syndrome (RLS) is considerably more common among adults with chronic kidney disease (CKD) than in the general population and is associated with increased morbidity and mortality. There is limited information on RLS in children with CKD. Failure to account for conditions that might mimic RLS can lead to overdiagnosis of this syndrome. In a prospective, cross-sectional study, RLS pr...

Effect of age at treatment on cognitive performance in patients with cystinosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676483
The Journal of Pediatrics; Viltz L, Trauner DA

Mar 6th, 2013 - To determine whether early treatment with cysteamine affects cognitive functioning in patients with nephropathic cystinosis. Forty-six subjects aged 3-18 years with cystinosis underwent cognitive testing to determine intelligence, visual-spatial abilities, and visual-motor skills. An age-matched control group (n = 85; age 2-22 years) underwent the same tests. Age at diagnosis and age at initiat...

Attenuated variants of Lesch-Nyhan disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842514
Brain : a Journal of Neurology; Jinnah HA, Ceballos-Picot I et. al.

Feb 23rd, 2010 - Lesch-Nyhan disease is a neurogenetic disorder caused by deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase. The classic form of the disease is described by a characteristic syndrome that includes overproduction of uric acid, severe generalized dystonia, cognitive disability and self-injurious behaviour. In addition to the classic disease, variant forms of the disease occur...