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About 383,610 results

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Effects of Tham Nasal Alkalinization on Airway Microbial Communities: A Pilot Study in ...
https://doi.org/10.1177/00034894211051814
The Annals of Otology, Rhinology, and Laryngology; Holliday ZM, Launspach JL et. al.

Oct 23rd, 2021 - In cystic fibrosis (CF), loss of CFTR-mediated bicarbonate secretion reduces the airway surface liquid (ASL) pH causing airway host defense defects. Aerosolized sodium bicarbonate can reverse these defects, but its effects are short-lived. Aerosolized tromethamine (THAM) also raises the ASL pH but its effects are much longer lasting. In this pilot study, we tested the hypothesis that nasally ad...

Preemptive analgesic effectiveness of single dose intravenous ibuprofen in infants unde...
https://doi.org/10.1186/s12887-021-02907-6 10.1016/j.clp.2015.02.005 10.1016/B978-0-323-06612-9.00025-0 10.1111/j.0001-5172.2004.00407.x 10.1111/j.1365-2044.1995.tb04509.x 10.1597/1545-1569_2002_039_0145_aofpao_2.0.co_2 10.1213/00000539-199377020-00026 10.1016/j.joms.2018.09.010 10.1111/pan.12302 10.1097/00000539-200104000-00020 10.1111/pan.12393 10.1016/j.phrs.2011.08.010 10.1111/pan.12381 10.1016/0952-8180(94)00001-k 10.1542/peds.2007-0064 10.1046/j.1460-9592.2000.00530.x 10.1597/14-080 10.1111/j.1460-9592.2006.02018.x 10.1111/j.1460-9592.2010.03347.x 10.1093/bja/74.5.506 10.1111/j.1460-9592.2010.03262.x 10.1097/SCS.0000000000006633 10.1097/EJA.0000000000000900 10.1097/PEC.0000000000001505
BMC Pediatrics; Peng ZZ, Wang YT et. al.

Oct 23rd, 2021 - Correction surgery for cleft palate is recommended between 9 and 18 months of age. Patients suffer from acute pain after palatoplasty. Clinicians are hesitant to use opioids for analgesia concerning the potential high risk of respiratory adverse events. Intravenous ibuprofen perhaps be a suitable adjuvant to pain relief. We try to assess whether preoperative administration of intravenous ibupro...

Atrial fibrillation following transcatheter atrial septal defect closure: a systematic ...
https://doi.org/10.1136/heartjnl-2021-319794
Heart (British Cardiac Society); Himelfarb JD, Shulman H et. al.

Oct 23rd, 2021 - The ostium secundum atrial septal defect (ASD) is among the most common congenital cardiac anomalies diagnosed in adulthood. A known complication of transcatheter ASD closure is the development of new-onset atrial fibrillation and flutter (AFi/AFl). These arrhythmias confer an increased risk of postoperative stroke, thrombus formation and systemic emboli. This systematic review examines the bur...

NOTCH2NLC-related disorders: the widening spectrum and genotype-phenotype correlation.
https://doi.org/10.1136/jmedgenet-2021-107883
Journal of Medical Genetics; Fan Y, Xu Y et. al.

Oct 23rd, 2021 - GGC repeat expansion in the 5' untranslated region of NOTCH2NLC is the most common causative factor in neuronal intranuclear inclusion disease (NIID) in Asians. Such expanded GGC repeats have been identified in patients with leukoencephalopathy, essential tremor (ET), multiple system atrophy, Parkinson's disease (PD), amyotrophic lateral sclerosis and oculopharyngodistal myopathy (OPDM). Herein...

Variation of Patent Ductus Arteriosus Treatment in Very Low Birth Weight Infants.
https://doi.org/10.1542/peds.2021-052874
Pediatrics Runte KE, Flyer JN et. al.

Oct 23rd, 2021 - Patent ductus arteriosus (PDA) treatment is common among very low birth weight (VLBW) infants. Given limitations in evidence, controversy exists regarding treatment risks and benefits. In this study, we describe PDA treatment trends and variation in a large, US, multicenter VLBW infant cohort. Data were collected through Vermont Oxford Network on 291 292 VLBW infants born 2012-2019 at 806 US NI...

Accurately Controlled Delivery of Temozolomide by Biocompatible UiO-66-NH2 Through Ultr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517532
International Journal of Nanomedicine; Wan Z, Li C et. al.

Oct 23rd, 2021 - Glioma is the most common and malignant primary brain tumour in adults and has a dismal prognosis. Temozolomide (TMZ) is the only clinical first-line chemotherapy drug for malignant glioma up to present. Due to poor aqueous solubility and toxic effects, TMZ is still inefficient and limited for clinical glioma treatment. UiO-66-NH2 nanoparticle is a zirconium-based framework, constructed by Zr a...

Lenvatinib Combined with Anti-PD-1 Antibodies Plus Transcatheter Arterial Chemoemboliza...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502053
Journal of Hepatocellular Carcinoma; Wu JY, Yin ZY et. al.

Oct 23rd, 2021 - Lenvatinib (LEN) combined with anti-PD-1 antibodies (PD-1) exerted promising effects on unresectable hepatocellular carcinoma (uHCC). We assessed the safety and clinical efficacy of triple therapy [LEN+PD-1+transcatheter arterial chemoembolization (TACE)] in uHCC. uHCC patients with an ECOG PS score of 0-1 and Child-Pugh class A who underwent triple therapy were included. The primary endpoint w...

The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their...
https://doi.org/10.1113/JP281707
The Journal of Physiology; Wilson AD, Hu J et. al.

Oct 23rd, 2021 - RyR2 mutations can cause type-1 catecholaminergic polymorphic ventricular tachycardia (CPVT1), a lethal, autosomal-dominant arrhythmic disease. However, the changes in RyR2 ion-channel function that result from the many different patient mutations are rarely investigated in detail and often only recombinant RyR2, homozygous for the mutation, are studied. As CPVT1 is a heterozygous disease and t...

LncRNA PTPRG-AS1 facilitates glycolysis and stemness properties of esophageal squamous ...
https://doi.org/10.1111/jgh.15719
Journal of Gastroenterology and Hepatology; Wu K, Wang Z et. al.

Oct 23rd, 2021 - Esophageal squamous cell carcinoma (ESCC) is the most significant subtype of esophageal cancer featured with high occurrence. Long noncoding RNAs (lncRNAs) have been proved to modulate the biological properties of cancer cells, including cell proliferation, invasion, migration and apoptosis. LncRNA protein tyrosine phosphatase receptor type G-antisense RNA 1 (PTPRG-AS1) has been reported to pla...

Exercise duration modulates upper and lower respiratory fluid cellularity, antiviral ac...
https://doi.org/10.14814/phy2.15075
Physiological Reports; Elkhatib SK, Alley J et. al.

Oct 23rd, 2021 - Exercise has substantial health benefits, but the effects of exercise on immune status and susceptibility to respiratory infections are less clear. Furthermore, there is limited research examining the effects of prolonged exercise on local respiratory immunity and antiviral activity. To assess the upper respiratory tract in response to exercise, we collected nasal lavage fluid (NALF) from human...

Dominant Clade-featured SARS-CoV-2 Co-occurring Mutations Reveals Plausible Epistasis: ...
https://doi.org/10.1002/jmv.27416
Journal of Medical Virology; Rubayet Ul Alam ASM, Islam OK et. al.

Oct 23rd, 2021 - SARS-CoV-2 is evolved into eight fundamental clades where four (G, GH, GR, and GV) are globally prevalent in 2020. To explain plausible epistatic effects of the signature co-occurring mutations of these circulating clades on viral replication and transmission fitness, we proposed a hypothetical model using in silico approach. Molecular docking and dynamics analyses showed the higher infectiousn...

Changes in Ventricular and Cortical Volumes following Shunt Placement in Patients with ...
https://doi.org/10.3174/ajnr.A7323
AJNR. American Journal of Neuroradiology; Cogswell PM, Murphy MC et. al.

Oct 23rd, 2021 - While changes in ventricular and extraventricular CSF spaces have been studied following shunt placement in patients with idiopathic normal pressure hydrocephalus, regional changes in cortical volumes have not. These changes are important to better inform disease pathophysiology and evaluation for copathology. The purpose of this work is to investigate changes in ventricular and cortical volume...

Arcuate nucleus overexpression of NHLH2 reduces body mass and attenuates obesity-associ...
https://doi.org/10.1523/JNEUROSCI.0222-21.2021
The Journal of Neuroscience : the Official Journal of The... Carraro RS, Nogueira GA et. al.

Oct 23rd, 2021 - Nescient helix-loop-helix 2 (NHLH2) is a hypothalamic transcription factor that controls the expression of prohormone convertase 1/3, therefore having an impact on the processing of proopiomelanocortin and thus on energy homeostasis. Studies have shown that knockout of Nhlh2 results in increased body mass, reduced physical activity and hypogonadism. In humans, a polymorphism of the NHLH2 gene i...

AXL inhibitor TP-0903 reduces metastasis and therapy resistance in pancreatic cancer.
https://doi.org/10.1158/1535-7163.MCT-21-0293
Molecular Cancer Therapeutics; Zhang Y, Arner EN et. al.

Oct 23rd, 2021 - Pancreatic cancer is the 3rd leading cause of cancer-related deaths in the United States with a 5-year survival less than 5%. Resistance to standard therapy and limited response to immune checkpoint blockade due to the immunosuppressive and stroma-rich microenvironment remain major challenges in the treatment of pancreatic cancer. A key cellular program involved in therapy resistance is epithel...

Reduction in O-glycome induces differentially glycosylated CD44 to promote stemness and...
https://doi.org/10.1038/s41388-021-02047-2 10.1002/path.2793 10.1016/j.bbcan.2018.10.006 10.1016/j.stem.2014.02.006 10.1158/0008-5472.CAN-06-2030 10.1038/s41388-019-1146-2 10.3390/ijms20061389 10.1053/j.gastro.2018.08.007 10.1038/bjc.2016.116 10.1038/s41416-020-0772-3 10.1073/pnas.1406619111 10.1136/jclinpath-2012-201169 10.1038/s41598-017-14364-2 10.1016/j.neo.2018.06.001 10.1016/j.bbagen.2016.03.008 10.1038/emboj.2013.79 10.1146/annurev-pathol-012414-040438 10.1007/s10719-019-09876-0 10.1038/nm0901-1028 10.1053/j.gastro.2018.05.041 10.1053/j.gastro.2013.01.072 10.1084/jem.183.4.1797 10.1038/bjc.2014.152 10.3390/biology6010016 10.1158/1078-0432.CCR-12-2662 10.1186/s13048-019-0574-5 10.1158/0008-5472.CAN-15-2834 10.1016/j.ebiom.2019.01.017 10.3390/cells5020016 10.1016/j.stem.2011.10.001 10.1111/jcmm.14572 10.1073/pnas.1305269110 10.1158/1055-9965.EPI-13-0785 10.1074/jbc.M800109200 10.3390/cancers11050655 10.3389/fonc.2018.00166 10.1002/anie.201002313 10.1016/j.semcancer.2015.02.006 10.1016/j.drudis.2013.05.005 10.1007/s13277-015-4690-6 10.1038/nmeth.3047 10.18632/oncotarget.6580
Oncogene Leon F, Seshacharyulu P et. al.

Oct 23rd, 2021 - Aberrant protein glycosylation has been shown to have a significant contribution in aggressive cancer, including pancreatic cancer (PC). Emerging evidence has implicated the involvement of cancer stem cells (CSCs) in PC aggressiveness; however, the contribution of glycosylation on self-renewal properties and maintenance of CSC is understudied. Here, using several in vitro and in vivo models lac...

The effect of mental health conditions on the use of oral anticoagulation therapy in pa...
https://doi.org/10.1093/ehjqcco/qcab077
European Heart Journal. Quality of Care & Clinical Outcomes; Jaakkola J, Teppo K et. al.

Oct 23rd, 2021 - Little is known about the effects of mental health conditions (MHC) on the utilization of oral anticoagulant (OAC) therapy in atrial fibrillation (AF) patients. We aimed to assess whether MHCs affect initiation of OAC therapy among AF patients with special focus on non-vitamin K-antagonist oral anticoagulants (NOAC). The FinACAF registry included all 239222 patients diagnosed with incident AF d...

Markers of Immune Activation and Inflammation in Individuals With Postacute Sequelae of...
https://doi.org/10.1093/infdis/jiab490
The Journal of Infectious Diseases; Peluso MJ, Lu S et. al.

Oct 23rd, 2021 - The biological processes associated with postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) are unknown. We measured soluble markers of inflammation in a SARS-CoV-2 recovery cohort at early (<90 days) and late (>90 days) timepoints. We defined PASC as the presence of 1 or more coronavirus disease 2019 (COVID-19)-attributed symptoms beyond 90 days...

Endogenous Leptin Concentrations Poorly Predict Metreleptin Response in Patients with P...
https://doi.org/10.1210/clinem/dgab760
The Journal of Clinical Endocrinology and Metabolism; Meral R, Malandrino N et. al.

Oct 23rd, 2021 - Leptin replacement with metreleptin improves glycemia and hypertriglyceridemia in severely hypoleptinemic patients with Generalized Lipodystrophy (GLD), but its effects are variable in partially leptin-deficient patients with Partial Lipodystrophy (PLD). Compare three leptin assays (Study I); identify diagnostic performance of leptin assays to detect responders to metreleptin for each assay (St...

What non-pharmacological treatments do people with polymyalgia rheumatica try: results ...
https://doi.org/10.1007/s00296-021-05036-6 10.1136/annrheumdis-2018-213883 10.1002/art.22777 10.1016/j.pec.2014.12.013 10.1001/archinternmed.2009.352 10.7326/0003-4819-141-7-200410050-00005 10.1007/s10067-018-04405-0 10.1007/s10067-018-4220-1 10.11124/JBISRIR-D-18-00020 10.1136/annrheumdis-2015-207492 10.1186/1471-2474-13-102 10.1093/rheumatology/kez533 10.4061/2011/681640 10.1136/bmjopen-2016-015711 10.1111/1756-185X.13480 10.1016/j.semarthrit.2020.05.003 10.1186/s13075-018-1757-y 10.1002/msc.82
Rheumatology International; Weddell J, Hider SL et. al.

Oct 23rd, 2021 - Polymyalgia rheumatica (PMR) is common. The mainstay of treatment, glucocorticoids, are associated with significant adverse effects and many patients remain on high doses for a number of years. Little is known about the use of other, non-pharmacological therapies as adjuncts in PMR. The PMR Cohort Study is an inception cohort study of patients diagnosed with PMR in primary care. This analysis p...