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Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line
https://www.mdpi.com/1467-3045/44/3/73/htm
Current Issues in Molecular Biology; Aldén M, .

Feb 25th, 2022 - Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro.

Pharmacometric and electrocardiographic evaluation of chloroquine and azithromycin in h...
https://doi.org/10.1002/cpt.2665
Clinical Pharmacology and Therapeutics; Chotsiri P, Tarning J et. al.

May 23rd, 2022 - Chloroquine and azithromycin were developed in combination for the preventive treatment of malaria in pregnancy, and more recently were proposed as COVID-19 treatment options. Billions of doses of chloroquine have been administered worldwide over the past 70 years but concerns regarding cardiotoxicity, notably the risk of torsades de pointes (TdP), remain. This investigation aimed to characteri...

A single immunization with cellular vaccine confers dual protection against SARS-CoV-2 ...
https://doi.org/10.1111/cas.15434
Cancer Science; Shimizu K, Ueda S et. al.

May 23rd, 2022 - The efficacy of current coronavirus disease 2019 (COVID-19) vaccines has been demonstrated; however, emerging evidence suggests insufficient protection in certain immunocompromised cancer patients. We previously developed a cell-based anti-cancer vaccine platform involving artificial adjuvant vector cells (aAVCs) capable of inducing a strong adaptive response by enhancing innate immunity. aAVCs...

Symptoms and signs of long COVID: A rapid review and meta-analysis.
https://doi.org/10.7189/jogh.12.05014
Journal of Global Health; Healey Q, Sheikh A et. al.

May 22nd, 2022 - Long COVID is defined as symptoms and signs related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that are present at least four weeks following acute infection. These symptoms and signs are poorly characterised but may be associated with significant morbidity. We sought to synthesise the evidence on their incidence to guide future research, policy and practice. We searched Me...

Outcomes of carotid sparing intensity-modulated radiotherapy for early stage glottic ca...
https://doi.org/10.1002/hed.27101
Head & Neck; Bicakci BC, Mustafayev TZ et. al.

May 22nd, 2022 - To assess and report clinical outcomes after carotid sparing intensity-modulated radiotherapy for early stage laryngeal cancer. We retrospectively analyzed 201 patients with early stage glottic laryngeal cancer treated with carotid sparing intensity-modulated radiotherapy (IMRT)/volumetric modulated arc therapy (VMAT) techniques in six TROD centers. After a median follow-up of 31 months the act...

In vitro activity of tedizolid and linezolid against multidrug-resistant Mycobacterium ...
https://doi.org/10.1016/j.diagmicrobio.2022.115714
Diagnostic Microbiology and Infectious Disease; Aono A, Murase Y et. al.

May 22nd, 2022 - The effects of tedizolid (TZD) against multidrug-resistant Mycobacterium tuberculosis isolates were investigated. This is possibly the first study to evaluate the MIC of TZD against Japanese Mycobacterium tuberculosis isolates. As TZD had a significantly lower MIC than LZD (P < 0.01), it was suggested to be a better, non-toxic alternative to LZD.

The global impact of household contact management for children on multidrug-resistant a...
https://doi.org/10.1016/S2214-109X(22)00113-9
The Lancet. Global Health; Dodd PJ, Mafirakureva N et. al.

May 22nd, 2022 - Estimates suggest that at least 30 000 children develop multidrug-resistant or rifampicin-resistant tuberculosis each year. Despite household contact management (HCM) being widely recommended, it is rarely done. We used mathematical modelling to evaluate the potential country-level and global effects and cost-effectiveness of multidrug-resistant or rifampicin-resistant tuberculosis HCM for chil...

Neurocognitive deficits in survivors of childhood acute myeloid leukemia.
https://doi.org/10.1186/s12887-022-03369-0 10.1111/ped.12865 10.1111/bjh.12040 10.1200/JCO.2000.18.18.3273 10.1200/JCO.2017.77.0180 10.1093/jnci/djq156 10.1002/1097-0142(197602)37:2+<1079::aid-cncr2820370815>3.0.co;2-d 10.2165/00002018-199005010-00003 10.1002/1097-0142(19870715)60:2<165::aid-cncr2820600207>3.0.co;2-g 10.1200/JCO.1987.5.6.927 10.1200/JCO.1986.4.4.571 10.1200/JCO.2008.18.7948 10.1038/leu.2013.153 10.1093/jjco/hyy061 10.1038/bmt.2012.244 10.1093/jnci/djaa102 10.1111/j.1467-9280.2006.01681.x 10.3758/bf03193017 10.1080/13803390903032529 10.1176/jnp.16.3.367 10.1097/MPH.0b013e31802d3e2d 10.1200/jco.1999.17.9.2804 10.1056/NEJMoa0900386 10.1200/JCO.2016.71.7587 10.1200/JCO.2015.62.2589 10.1038/s41375-021-01134-3 10.3390/cancers13050966 10.1200/JCO.2012.46.7944 10.1200/JCO.2017.76.4696 10.1136/adc.2008.153809
BMC Pediatrics; Takahashi S, Sato S et. al.

May 22nd, 2022 - Although treatment of acute myeloid leukemia (AML) contains neurotoxic agents, studies investigating neurocognitive outcomes in children with AML are sparse. We evaluated late cognitive effects in children treated with a high-dose cytarabine based regimen, focusing on general intellectual ability and specific neurocognitive domains. We evaluated 12 survivors of childhood AML who were treated be...

Quaternary Nanoparticles Enable Sustained Release of Bortezomib for Hepatocellular Carc...
https://doi.org/10.1002/hep.32584
Hepatology (Baltimore, Md.); Li L, Zhang Y et. al.

May 22nd, 2022 - Hepatocellular carcinoma (HCC) represents the 3rd leading cause of cancer-related mortality in the world. Over the past 2 decades, there has been minimal improvement in therapies as well as clinical outcomes for Barcelona Clinic Liver Cancer (BCLC)-B patients. These patients are treated with local interventions, including trans-arterial chemoembolization (TACE). Current methodologies only allow...

Effects of disease-modifying treatments discontinuation in patients with relapsing-remi...
https://doi.org/10.1016/j.msard.2022.103857
Multiple Sclerosis and Related Disorders; Bawand R, Ghiasian M et. al.

May 22nd, 2022 - One of the most challenging issues in patients with multiple sclerosis is the discontinuation of Disease-Modifying Treatments (DMTs) and subsequent complications. We aimed to investigate the extent of adherence to DMTs in naïve multiple sclerosis patients, outcomes of non-adherence to treatments, and the risk factors that lead to drug discontinuation. In this prospective cohort study, 288 naïve...

Home treatment against fatigue in multiple sclerosis by a personalized, bilateral whole...
https://doi.org/10.1016/j.msard.2022.103813
Multiple Sclerosis and Related Disorders; Tecchio F, Cancelli A et. al.

May 22nd, 2022 - Fatigue in multiple sclerosis (MS) is a highly invalidating symptom with no pharmacological efficacious therapies, which furthermore present frequent severe side effects. In two previous randomized controlled trials we observed the efficacy of a personalized neuromodulation treatment consisting of a personalized transcranial Direct Current Stimulation (tDCS) for 15 min per day for 5 days (Farem...

Immunoinformatic paradigm predicts macrophage and T-cells epitope responses against glo...
https://doi.org/10.1016/j.intimp.2022.108847
International Immunopharmacology; Maiti S, Banerjee A et. al.

May 22nd, 2022 - Different quickly-developed vaccines are introduced against COVID-19 with inconclusive results especially against some recent variants. Eventually, somewhere COVID-19 cases decline and in some countries it revived with some new mutant-variants (i.e. D614G, Delta and Omicron). Proposing a universal vaccination strategy by screening globally-conserved SARS-CoV-2 spike-epitopes. Presently, several...

BCG Vaccination: A potential tool against COVID-19 and COVID-19-like Black Swan incidents.
https://doi.org/10.1016/j.intimp.2022.108870
International Immunopharmacology; Gong W, Mao Y et. al.

May 22nd, 2022 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19), and its variants have brought unprecedented impacts to the global public health system, politics, economy, and other fields. Although more than ten COVID-19 specific vaccines have been approved for emergency use, COVID-19 prevention and control still face many challe...

Trained immunity: implications for vaccination.
https://doi.org/10.1016/j.coi.2022.102190
Current Opinion in Immunology; Geckin B, Konstantin Föhse F et. al.

May 22nd, 2022 - The concept that only adaptive immunity can build immunological memory has been challenged in the past decade. Live attenuated vaccines such as the Bacillus Calmette-Guérin, measles-containing vaccines, and the oral polio vaccine have been shown to reduce overall mortality beyond their effects attributable to the targeted diseases. After an encounter with a primary stimulus, epigenetic and meta...

Prevalence of bovine Babesia spp., Anaplasma marginale, and their co-infections in Lati...
https://doi.org/10.1016/j.ttbdis.2022.101967
Ticks and Tick-borne Diseases; Ferreira GCM, Canozzi MEA et. al.

May 22nd, 2022 - Bovine parasitic sadness, comprised of the diseases babesiosis and anaplasmosis, has a large impact on cattle farming in several countries, as it compromises animal productivity. Using systematic review (SR)-meta-analysis (MA) methodology, our objective was to summarize and to investigate study characteristics associated with prevalence of Babesia spp. and Anaplasma marginale infection in Latin...

Cerebellar transcranial direct current stimulation modulates timing but not acquisition...
https://doi.org/10.1016/j.brs.2022.05.013
Brain Stimulation; Maas RPPWM, Schutter DJLG et. al.

May 22nd, 2022 - Delay eyeblink conditioning is an extensively studied motor learning paradigm that critically depends on the integrity of the cerebellum. In healthy individuals, modulation of cerebellar excitability using transcranial direct current stimulation (tDCS) has been reported to alter the acquisition and/or timing of conditioned eyeblink responses (CRs). It remains unknown whether such effects can al...

Protective mechanisms harnessing against injurious heme and preventing kidney damage in...
https://doi.org/10.1016/j.kint.2022.02.026
Kidney International; Wagener FADTG, van de Kar NCAJ et. al.

May 22nd, 2022 - Hemolytic uremic syndrome can be initiated by Escherichia coli infections (Shiga-toxin-producing enterohemorrhagic Escherichia coli hemolytic uremic syndrome). When hemoglobin and heme released from ruptured erythrocytes interact with the kidney cells, this can result in platelet activation, vascular inflammation and occlusion, and kidney injury. Pirschel et al. now report that in the absence o...

Clinical and functional outcome of total hip arthroplasty in patients with acromegaly: ...
https://doi.org/10.1007/s00264-022-05447-5 10.1210/jc.2014-2700 10.1023/a:1009965803750 10.1007/s11102-016-0754-x 10.3389/fendo.2019.00268 10.1210/jcem.83.10.5222 10.1210/jc.2003-032041 10.1210/jc.2003-031199 10.1530/EJE-16-0117 10.1210/jc.2004-2297 10.1016/j.ghir.2010.02.003 10.1530/EJE-08-0845 10.1002/art.1780330332 10.1007/BF03347225 10.1136/ard.30.3.243 10.1155/2012/839282 10.23938/ASSN.0928 10.1210/jc.2008-2393 10.1007/s00264-011-1235-5 10.1136/bmjopen-2019-033045 10.1016/j.ghir.2021.101389 10.1210/clinem/dgaa747 10.1302/0301-620X.75B2.8444942 10.2106/00004623-199702000-00003 10.1302/0301-620X.69B1.3818732 10.1007/s40618-020-01268-8 10.1136/ard.2010.131698 10.1016/j.ghir.2013.05.003 10.1016/j.joca.2014.08.015 10.1097/00003086-198303000-00017 10.13107/jocr.2250-0685.768
International Orthopaedics; Akkaya M, Pignataro A et. al.

May 22nd, 2022 - Acromegaly is a rare and chronic hormonal disorder. Persons with acromegaly frequently live well into adulthood. Patients with active acromegaly have multiple joint-related issues; however, acromegalic arthropathy (AA), which is secondary osteoarthritis (OA), is considered one of the most common musculoskeletal complications of acromegaly. This study aims to analyze a cohort of patients who und...

Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and ...
https://doi.org/10.1038/s41416-022-01839-x 10.1038/nrgastro.2011.20 10.1053/j.gastro.2013.10.013 10.1038/nrgastro.2016.51 10.1038/s41575-020-0310-z 10.1016/S0140-6736(13)61903-0 10.1056/NEJMoa1910836 10.1056/NEJMoa1606774 10.1001/jamaoncol.2020.0930 10.1001/jamaoncol.2020.2814 10.1016/j.cell.2014.12.021 10.1038/nm.4438 10.1016/j.stem.2016.04.003 10.1038/s41467-018-05190-9 10.1016/j.cell.2017.11.010 10.1016/j.cell.2015.03.053 10.1016/j.stem.2018.09.016 10.1016/j.canlet.2021.06.007 10.1186/s12885-018-4238-4 10.1080/2162402X.2020.1845424 10.1016/j.cell.2018.07.009 10.1016/j.celrep.2019.03.088 10.1016/j.celrep.2018.07.001 10.1053/j.gastro.2017.10.043 10.1053/j.gastro.2017.06.017 10.1158/2326-6066.CIR-21-0058 10.1038/nprot.2008.211 10.1093/nar/gkn923 10.1016/S0973-6883(11)60110-2 10.1007/s10620-014-3472-0 10.1002/hep.28493 10.1084/jem.190.12.1879 10.1002/jcp.27782 10.1038/s41577-018-0044-0 10.3389/fonc.2019.00989
British Journal of Cancer; Zhou G, Lieshout R et. al.

May 22nd, 2022 - Immunotherapy with immune checkpoint inhibitors (ICIs) is being explored to improve cholangiocarcinoma (CCA) therapy. However, it remains difficult to predict which ICI will be effective for individual patients. Therefore, the aim of this study is to develop a co-culture method with patient-derived CCA organoids and immune cells, which could represent anti-cancer immunity in vitro. CCA organoid...

When Is Mass Prophylaxis Cost-Effective for Epidemic Control? A Comparison of Decision ...
https://doi.org/10.1177/0272989X221098409
Medical Decision Making : an International Journal of The... Malloy GSP, Brandeau ML

May 21st, 2022 - For certain communicable disease outbreaks, mass prophylaxis of uninfected individuals can curtail new infections. When an outbreak emerges, decision makers could benefit from methods to quickly determine whether mass prophylaxis is cost-effective. We consider 2 approaches: a simple decision model and machine learning meta-models. The motivating example is plague in Madagascar. We use a suscept...