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About 22,275 results

Breast Conserving Surgery in Combination With Targeted Intraoperative Radiotherapy Comp...
https://doi.org/10.21873/anticanres.16212
Anticancer Research; Kolberg HC, Niesing H et. al.

Jan 26th, 2023 - Mastectomy is the standard treatment of in-breast-recurrence of breast cancer after breast conserving surgery (BCS) and external beam radiation therapy (EBRT). In selected cases, it is possible to preserve the breast if targeted intraoperative radiotherapy (TARGIT-IORT) can be given during the second lumpectomy. This is a comparative analysis of overall survival and quality of life (QoL). Patie...

Carbon Ion Radiotherapy Versus Perioperative Adjuvant Chemotherapy and Curative Surgery...
https://doi.org/10.21873/anticanres.16222
Anticancer Research; Yamamoto N, Oshima T et. al.

Jan 26th, 2023 - The standard treatment for resectable pancreatic cancer is preoperative adjuvant chemotherapy (NAC) + curative surgery + adjuvant chemotherapy. Although excellent local control results of carbon ion radiotherapy (CIRT) for pancreatic cancer have been reported, no reports have compared CIRT with the standard treatment for resectable pancreatic cancer. In this study, we compared the results of CI...

Observation of the delineation of the target volume of radiotherapy in adult-type diffu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872393
Radiation Oncology (London, England); Liu H, Zhang L et. al.

Jan 24th, 2023 - Radiation therapy is the cornerstone of treatment for adult-type diffuse gliomas, but recurrences are inevitable. Our study assessed the prognosis and recurrence pattern of different radiotherapy volumes after temozolomide-based chemoradiation in our institution. The treatment plans were classified into two groups, the plan 1 intentionally involved the entire edema area while plan 2 did not. Re...

Radiosensitization with Gadolinium Chelate-Coated Gold Nanoparticles Prevents Aggressiv...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844821
International Journal of Nanomedicine; Durand M, Chateau A et. al.

Jan 21st, 2023 - This study aimed to evaluate the radiosensitizing potential of Au@DTDTPA(Gd) nanoparticles when combined with conventional external X-ray irradiation (RT) to treat GBM. Complementary biological models based on U87 spheroids including conventional 3D invasion assay, organotypic brain slice cultures, chronic cranial window model were implemented to investigate the impact of RT treatments (10 Gy s...

Predicting Nomogram for Severe Oral Mucositis in Patients with Nasopharyngeal Carcinoma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857735
Current Oncology (Toronto, Ont.); Liu Z, Huang L et. al.

Jan 21st, 2023 - Oral mucositis is an acute adverse reaction with high incidence during radiotherapy. Severe oral mucositis can seriously affect patients' quality of life and compliance with radiotherapy. The aim of this study was to identify the risk factors for severe oral mucositis and to develop a nomogram for predicting severe oral mucositis in patients with nasopharyngeal carcinoma. One hundred and ninety...

Postoperative radiotherapy timing, molecular subgroups and treatment outcomes of Thai p...
https://doi.org/10.1371/journal.pone.0271778
PloS One; Jaruthien T, Nantavithya C et. al.

Jan 18th, 2023 - Medulloblastoma (MB) is the most common childhood malignant brain tumor worldwide. Recently, molecular classification was established and started to play a role in the management of MB; however, studies involving molecular defined MB in Southeast Asia have been limited. We aimed to describe, and correlate clinical characteristics and molecular subgroups with therapeutic outcomes of Thai pediatr...

Case report of intracranial large vessel occlusion in glioblastoma multiforme patient a...
https://doi.org/10.1097/MD.0000000000032682
Medicine Chien-Tung Y, Chen CC

Jan 14th, 2023 - Vasculopathy of the large arteries is a prominent complication of radiotherapy. Radiation-induced cerebral vasculopathy can cause arterial stenosis/occlusion, cerebral hemorrhage, and aneurysm formation. We report a cases of glioblastoma multiforme (GBM) with occlusive radiation vasculopathy (ORV). This 28-year-old patient who suffered from GBM had surgery for cytoreduction and received postope...

Paraneoplastic leukemoid syndrome in squamous cell carcinoma of the forearm.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843158
BMJ Case Reports; Das S, Shaikh OH et. al.

Jan 13th, 2023 - The paraneoplastic leukemoid reaction is a rare haematological paraneoplastic syndrome, which is typically seen with solid tumours and squamous cell carcinomas. As an indication of bone marrow infiltration and malignancy involvement, it indicates a poor outcome and a grave prognosis. We report a woman in her 50s, who presented with an ulcer over the right forearm. Biopsy revealed squamous cell ...

Lymphoscintigraphy in patients with breast cancer-related lymphedema after sentinel lym...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750707
Medicine Oh SH, Kim JH et. al.

Jan 11th, 2023 - The purpose of this study was to investigate lymphoscintigraphy pattern according to the presence or absence of axillary site radiation therapy (aRTx) in breast cancer-related lymphedema (BCRL) patients who underwent sentinel lymph node dissection (SLND). The participants were patients who visited our facility from July 2014 to June 2021 due to upper extremity edema. Among them, patients who un...

Dosimetric quality of HyperArc in boost radiotherapy for single glioblastoma: compariso...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832781
Radiation Oncology (London, England); Pan M, Xu W et. al.

Jan 11th, 2023 - Stereotactic radiotherapy (SRT) and hypo-fractionated radiotherapy are feasible treatment options for single glioblastoma multiforme when combined with conventional radiotherapy or delivered alone. HyperArc (HA), a novel linac-based method with 4 noncoplanar arcs, has been introduced into stereotactic radiosurgery (SRS) for single and multiple metastases. In this study, we compared the dosimetr...

Health-related quality of life and patient-reported symptoms after postoperative proton...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827629
Radiation Oncology (London, England); Meixner E, Wark A et. al.

Jan 10th, 2023 - The APROVE-trial investigated the tolerability of postoperative proton beam therapy in women with cervical or endometrial cancer. The present analysis evaluated the secondary endpoints of health-related quality of life (HRQOL) and patient-reported symptoms. 25 patients were included in this prospective phase-II-trial and treated with postoperative radiotherapy using protons alone or in combinat...

A two-stage genome-wide association study identifies novel germline genetic variations ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830790
Journal of Translational Medicine; Yu LL, Hu BW et. al.

Jan 10th, 2023 - Radiotherapy (RT) is the standard treatment for nasopharyngeal carcinoma (NPC). However, due to individual differences in radiosensitivity, biomarkers are needed to tailored radiotherapy to cancer patients. However, comprehensive genome-wide radiogenomic studies on them are still lacking. The aim of this study was to identify genetic variants associated with radiotherapy response in patients wi...

PROshot: DCIS Boost, Radiation Alone for Nasopharyngeal Carcinoma, Prostate SBRT, Sarco...
https://doi.org/10.1016/j.prro.2022.10.006
Practical Radiation Oncology; Dulaney C, Dover L

Jan 6th, 2023 - PROshot: DCIS Boost, Radiation Alone for Nasopharyngeal Carcinoma, Prostate SBRT, Sarcoma Lung Metastases, Merkel Cell Carcinoma Abscopal Effect, and Response-Adapted Breast Cancer Radiation.|2023|Dulaney C,Dover L,|pathology,radiotherapy,pathology,radiotherapy,pathology,

Clinical characteristics and prognostic factors affecting survival after radical radiot...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811739
BMC Cancer; Jia GD, Sun XS et. al.

Jan 4th, 2023 - We compared the clinical characteristics and survival outcomes after radical radiotherapy between nasopharyngeal carcinoma (NPC) with early and late metastases based on a relatively large cohort, which provides valuable data for the planning of clinical surveillance strategies. This was a single-center retrospective analysis of 10,566 patients who received radical radiotherapy in China from Jan...

Automating the treatment planning process for 3D-conformal pediatric craniospinal irrad...
https://doi.org/10.1002/pbc.30164
Pediatric Blood & Cancer; Hernandez S, Nguyen C et. al.

Jan 3rd, 2023 - Pediatric patients with medulloblastoma in low- and middle-income countries (LMICs) are most treated with 3D-conformal photon craniospinal irradiation (CSI), a time-consuming, complex treatment to plan, especially in resource-constrained settings. Therefore, we developed and tested a 3D-conformal CSI autoplanning tool for varying patient lengths. Autocontours were generated with a deep learning...

Proof of Concept of the Radiosensitizing Effect of Gadolinium Oxide Nanoparticles in Ce...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793741
International Journal of Nanomedicine; Aloy MT, Sidi Boumedine J et. al.

Dec 31st, 2022 - Chondrosarcomas (CHSs), which represent 20% of primary bone tumors in adults, are mostly resistant to radio- and chemotherapy. It is therefore essential that new therapeutic approaches, targeted to the tumour, be developed to improve the prognosis of patients. The effectiveness, as a radiosensitizing agent, of gadolinium oxide nanoparticles (GdoNP, AGuIX®) nanoparticles in CHS was evaluated in ...

A phase III, multicenter, randomized controlled trial of preoperative versus postoperat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805276
BMC Cancer; Das S, Faruqi S et. al.

Dec 31st, 2022 - Postoperative stereotactic radiosurgery (SRS) is a standard management option for patients with resected brain metastases. Preoperative SRS may have certain advantages compared to postoperative SRS, including less uncertainty in delineation of the intact tumor compared to the postoperative resection cavity, reduced rate of leptomeningeal dissemination postoperatively, and a lower risk of radiat...

Stereotactic ablative radiotherapy or best supportive care in patients with localized p...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801528
BMC Cancer; Doppenberg D, Besselink MG et. al.

Dec 30th, 2022 - Significant comorbidities, advanced age, and a poor performance status prevent surgery and systemic treatment for many patients with localized (non-metastatic) pancreatic ductal adenocarcinoma (PDAC). These patients are currently treated with 'best supportive care'. Therefore, it is desirable to find a treatment option which could improve both disease control and quality of life in these patien...

Escalation of radiotherapy dose in large locally advanced drug-resistant gastrointestin...
https://doi.org/10.1186/s13014-022-02179-z
Radiation Oncology (London, England); Cui H, Li Y et. al.

Dec 29th, 2022 - Resistance to conventional dose schemes and radiotoxicity of healthy tissue is a clinical challenge in the radiation therapy of large locally advanced drug-resistant gastrointestinal stromal tumor (LADR-GIST). This study aimed to assess the feasibility of using multi-shell Simultaneous Integrated Boost Intensity-Modulated modality (SIB-IMRT) strategy to provide a safe and effective escalation d...

miR-4443 promotes radiation resistance of esophageal squamous cell carcinoma via target...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795664
Journal of Translational Medicine; Shi X, Liu X et. al.

Dec 29th, 2022 - Radiotherapy is one of the main treatments for esophageal squamous cell carcinoma (ESCC), but its efficacy is limited by radioresistance. MicroRNAs play a crucial role in posttranscriptional regulation, which is linked to the cancer response to radiation. We successfully established a radioresistant cell line model by using fractionated irradiation. qRT-PCR was adopted to detect the expression ...