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About 20,813 results

Evaluating the Efficacy of EGFR-TKIs Combined With Radiotherapy in Advanced Lung Adenoc...
https://doi.org/10.1177/15330338221100358
Technology in Cancer Research & Treatment; Wang Y, Yu W et. al.

May 25th, 2022 - Objective: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been recommended as the first-line treatment for advanced lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutation. This study retrospectively evaluated patients' survival and related prognostic factors from single-center, real-world data. Methods: From January 2015 to December 2020, patient...

Radiotherapy-drug combinations in the treatment of glioblastoma: a brief review.
https://doi.org/10.2217/cns-2021-0015
CNS Oncology; McAleavey PG, Walls GM et. al.

May 24th, 2022 - Glioblastoma (GBM) accounts for over 50% of gliomas and carries the worst prognosis of all solid tumors. Owing to the limited local control afforded by surgery alone, efficacious adjuvant treatments such as radiotherapy (RT) and chemotherapy are fundamental in achieving durable disease control. The best clinical outcomes are achieved with tri-modality treatment consisting of surgery, RT and sys...

Prognostic value of cervical nodal necrosis on staging imaging of nasopharyngeal carcin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123677
Cancer Imaging : the Official Publication of the Internat... Ai QH, Hung KF et. al.

May 21st, 2022 - To systematically review and perform meta-analysis to evaluate the prognostic value of cervical nodal necrosis (CNN) on the staging computed tomography/magnetic resonance imaging (MRI) of nasopharyngeal carcinoma (NPC) in era of intensity-modulated radiotherapy. Literature search through PubMed, EMBASE, and Cochrane Library was conducted. The hazard ratios (HRs) with 95% confidence intervals (C...

Hematologic Toxicity Comparison of Intensity Modulated Proton Therapy and Intensity Mod...
https://doi.org/10.1097/COC.0000000000000916
American Journal of Clinical Oncology; Nelson B, Tadesse DG et. al.

May 20th, 2022 - We hypothesize that hematologic toxicity will be lower in anal cancer patients treated definitively with intensity modulated proton therapy (IMPT) compared with patients treated with intensity modulated radiation therapy (IMRT). Patients enrolled on a prospective feasibility trial assessing the use of IMPT for anal cancer were compared with contemporaneous patients treated with IMRT. Blood coun...

Iodine-125 Seeds Inhibit Carcinogenesis of Hepatocellular Carcinoma Cells by Suppressin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107354
Disease Markers; Yang C, Xiao Y et. al.

May 18th, 2022 - To investigate the radioactive iodine-125 (I-125) seed on migrating and invading of hepatocellular carcinoma (HCC) cells and its mechanism, the irradiation of PLC and Huh7 cells was carried out with I-125 seeds in vitro. Cell counting kit 8 assay was employed to measure cell viability. Cell migration was evaluated by using wound-healing assay. Cell invasion was detected by Transwell assay; RT-P...

Neoadjuvant irradiation of extremity soft tissue sarcoma with ions (Extrem-ion): study ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097299
BMC Cancer; Brügemann D, Lehner B et. al.

May 14th, 2022 - The standard of care treatment for soft tissue sarcoma of the extremities is a wide resection in combination with pre- or postoperative radiotherapy with high local control rates, sparing patients the necessity of amputation without compromising on overall survival rates. The currently preferred timing of radiotherapy is under debate. Albeit having higher rates of acute wound complications, lat...

Effect of Body Size Change on Off-Center Cervical Point and Face Doses in Patients Unde...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061042
Disease Markers; Fang M, Xu L et. al.

May 6th, 2022 - Nasopharyngeal carcinoma (NPC) is a clinically multiple malignant tumor. At present, with the increase in the infection rate of Epstein-Barr virus, the incidence of nasopharyngeal carcinoma is also increasing day by day. To explore the effect of body size change on off-center cervical point and face doses in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy, in total, 100 pat...

First-in-Human Experience With 177Lu-DOTAGA.(SA.FAPi)2 Therapy in an Uncommon Case of A...
https://doi.org/10.1097/RLU.0000000000004164
Clinical Nuclear Medicine; Ballal S, Yadav MP et. al.

May 5th, 2022 - A 56-year-old man was diagnosed with calcitonin negative, plasma chromogranin A-positive, immunohistochemistry-negative, high-grade MTC (medullary thyroid cancer) behaving clinically like anaplastic thyroid cancer and presented with progressive disease after conventional therapies. A theranostic approach of 68Ga-DOTA.SA.FAPi-guided 177Lu-DOTAGA.(SA.FAPi)2 radionuclide therapy was administered o...

Assessment of therapeutic outcome and role of reirradiation in patients with radiation-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066974
Radiation Oncology (London, England); Ohno M, Miyakita Y et. al.

May 4th, 2022 - We sought to clarify the optimal follow-up, therapeutic strategy, especially the role of reirradiation, and the diagnostic impact of isocitrate dehydrogenase (IDH) 1 and 2 mutation status in patients with radiation-induced glioma (RIG). We retrospectively reviewed the clinical characteristics and treatment outcomes of 11 patients with high-grade glioma who satisfied Cahan's criteria for RIG in ...

Cutaneous dystrophic calcification following high-dose radiotherapy for a liposarcoma.
https://doi.org/10.5070/D3271256702
Dermatology Online Journal; Green AR, Durkin J

May 3rd, 2022 - Cutaneous dystrophic calcification as a late change of radiation therapy is a rarely reported finding. Initially, it was almost exclusively described as occurring on the chest wall in breast cancer patients but has since been described in several other malignancies. We describe the first reported case of radiotherapy-induced calcinosis cutis occurring at the site of a previous liposarcoma. Revi...

Evaluation of patients with oral squamous cell carcinoma treated by radical irradiation...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052617
Journal of Medical Case Reports; Noguchi T, Sugiura Y et. al.

Apr 30th, 2022 - It is very important to determine the indication of mold radiotherapy for the radical treatment of oral cancer. We investigated eight patients with oral squamous cell carcinoma who were treated by radical irradiation with mold radiotherapy using a customized device. The subject is a case of curable superficial oral cancer of a few millimeters, or cancer of a size that can be cured by the placem...

Intensity-modulated radiotherapy with more than 60 Gy improved the survival of inoperab...
https://doi.org/10.1097/MD.0000000000029166
Medicine Zhang W, Xie Q et. al.

Apr 29th, 2022 - Intensity-modulated radiotherapy (IMRT) is widely applied during the treatment of esophageal squamous cell carcinoma (ESCC), but the optimal radiation dose still lacks a consensus. The aim of this study was to explore the optimal radiation dose for inoperable locally advanced ESCC patients treated with IMRT in a real-world clinical setting.A total of 90 inoperable ESCC patients with locally adv...

Yttrium-90 for colorectal liver metastasis - the promising role of radiation segmentect...
https://doi.org/10.1080/02656736.2021.1933215
International Journal of Hyperthermia : the Official Jour... Entezari P, Gabr A et. al.

Apr 26th, 2022 - The majority of patients with metastatic colorectal cancer (CRC) to the liver are not amenable to curative-intent surgery or thermal ablation; there is a need for alternative locoregional therapies to control oligometastatic liver disease. Sequential lobar Yttrium-90 (Y90) radioembolization has demonstrated favorable results in the salvage setting for CRC patients with liver only or liver-domin...

CENPM upregulation by E5 oncoprotein of human papillomavirus promotes radiosensitivity ...
https://doi.org/10.1016/j.oraloncology.2022.105858
Oral Oncology; Liu T, Ma L et. al.

Apr 25th, 2022 - This study aims to investigate how human papillomavirus (HPV) affects the key gene in the biological behaviors of head and neck squamous cell carcinoma (HNSCC) that leads to better response to radiotherapy. The expression of key gene CENPM was analyzed using The Cancer Genome Atlas (TCGA) HNSCC data and HPV positive and HPV negative HNSCC tumors and cells. Assays with siRNAs, CRISPR/Cas9-based ...

Treatment results for patients with squamous-cell carcinoma of the anus, a single insti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022342
Radiation Oncology (London, England); Neelis KJ, Kip DM et. al.

Apr 22nd, 2022 - To gain insight into the treatment outcomes for anal cancer a retrospective analysis was performed with a special emphasis on trends in outcome and toxicities over time and on treatment of elderly patients. Medical records of 98 consecutive patients with squamous cell carcinoma of the anus of all stages treated with curative intent between 01-01-2009 and 31-12-2018 were analyzed with follow up ...

Ectopic Recurrence of Skull Base Chordoma after Proton Therapy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026729
Current Oncology (Toronto, Ont.); Santegoeds RGC, Alahmari M et. al.

Apr 22nd, 2022 - Chordoma are rare tumors of the axial skeleton. The treatment gold standard is surgery, followed by particle radiotherapy. Total resection is usually not achievable in skull base chordoma (SBC) and high recurrence rates are reported. Ectopic recurrence as a first sign of treatment failure is considered rare. Favorable sites of these ectopic recurrences remain unknown. Five out of 16 SBC patient...

Optimization of the Clinical Effectiveness of Radioembolization in Hepatocellular Carci...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024927
Current Oncology (Toronto, Ont.); d'Abadie P, Walrand S et. al.

Apr 22nd, 2022 - Selective internal radiation therapy (SIRT) is part of the treatment strategy for hepatocellular carcinoma (HCC). Strong clinical data demonstrated the effectiveness of this therapy in HCC with a significant improvement in patient outcomes. Recent studies demonstrated a strong correlation between the tumor response and the patient outcome when the tumor-absorbed dose was assessed by nuclear med...

Glioblastoma Recurrence Versus Radiotherapy Injury: Combined Model of Diffusion Kurtosi...
https://doi.org/10.1097/RLU.0000000000004167
Clinical Nuclear Medicine; Dang H, Zhang J et. al.

Apr 20th, 2022 - To evaluate the diagnostic potential of decision-tree model of diffusion kurtosis imaging (DKI) and 11C-methionine (11C-MET) PET, for the differentiation of radiotherapy (RT) injury from glioblastoma recurrence. Eighty-six glioblastoma cases with suspected lesions after RT were retrospectively enrolled. Based on histopathology or follow-up, 48 patients were diagnosed with local glioblastoma rec...

Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosens...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013114
Journal of Experimental & Clinical Cancer Research : CR; Salah M, Akasaka H et. al.

Apr 17th, 2022 - Despite recent advances in radiotherapy, radioresistance in patients with pancreatic cancer remains a crucial dilemma for clinical treatment. Cancer stem cells (CSCs) represent a major factor in radioresistance. Developing a potent radiosensitizer may be a novel candidate for the eradication of pancreatic CSCs. CSCs were isolated from MIA PaCa-2 and PANC1 human pancreatic cancer cell lines. Tit...

The Janus Face in Defining the Optimal Radiation Dose for Nasopharyngeal Carcinoma.
https://doi.org/10.1016/j.ijrobp.2022.01.032
International Journal of Radiation Oncology, Biology, Phy... Ng SP, Corry J et. al.

Apr 16th, 2022 - The Janus Face in Defining the Optimal Radiation Dose for Nasopharyngeal Carcinoma.|2022|Ng SP,Corry J,Ng WT,|radiotherapy,radiotherapy,