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About 18,848 results

The effect of combined TPF and intensity modulated radiotherapy after TPF induction che...
https://doi.org/10.21037/apm-21-2073
Annals of Palliative Medicine; Zheng L, Xu Q et. al.

Oct 12th, 2021 - To evaluate the efficacy and toxicity of docetaxel, cisplatin, and fluorouracil (TPF) regimen followed by intensity modulated radiotherapy (IMRT) on locally advanced nasopharyngeal carcinoma (NPC). A total of 150 patients with locally advanced NPC [American Joint Committee on Cancer (AJCC) 2009 stage IIIa-IVb] received 2 or 3 cycles of a TPF regimen as induction chemotherapy. A group of 67 part...

Intensity-modulated Radiotherapy in Patients With Aggressive Extranodal Non-Hodgkin Lym...
https://doi.org/10.21873/anticanres.15330
Anticancer Research; Eismann J, Elsayad K et. al.

Oct 2nd, 2021 - Image-guided intensity-modulated radiotherapy (IG-IMRT) is increasingly being used to treat patients with head and neck malignancies. This analysis compared conventional radiotherapy (CRT) and IMRT outcomes for head and neck aggressive extranodal non-Hodgkin lymphomas (EN-NHL). Forty-eight patients who underwent irradiation between 2005 and 2019 were identified. The median follow-up was 42 mont...

Symptom Outcomes of Cancer Patients With Clival Metastases Treated With Radiotherapy: A...
https://doi.org/10.21873/anticanres.15314
Anticancer Research; Sturgis R, Mack A et. al.

Oct 2nd, 2021 - To describe clinical features, radiotherapy (RT), and symptom outcomes in cancer patients with cranial nerve palsies associated with clival metastases. This is a retrospective review of patients with primary metastatic cancers who developed clival metastases and received RT (2000-2020). Of the 44 patients with primary cancers (manly breast, prostate and multiple myeloma cancers) and distal cliv...

Adjuvant Radiotherapy in Patients With Pancreatic Adenocarcinoma. Is It Still Appealing...
https://doi.org/10.21873/anticanres.15283
Anticancer Research; Pasqualetti F, Sainato A et. al.

Oct 2nd, 2021 - Pancreatic adenocarcinoma is a life-threatening disease with a rising frequency and the fourth leading cause of cancer death. This review aimed to assess the impact of postoperative radiotherapy through a meta-analysis of prospective randomized studies. Six studies met the inclusion criteria and were analyzed to calculate the cumulative risk of death (hazard ratio) in patients affected by pancr...

Combined Chemoembolization and Ablation Effective for Early Stage Hepatocellular Carcinoma
https://www.medscape.com/viewarticle/960033

Oct 1st, 2021 - (Reuters Health) - Transcatheter arterial chemoembolization combined with radiofrequency ablation works better as an initial treatment for early-stage hepatocellular carcinoma than radiofrequency ablation alone, a new study suggests. For the study, researchers examined long-term data on 189 clinical trial participants with early-stage hepatocellular carcinoma who had been randomized 1:1 to rece...

Association of neutrophil-to-lymphocyte ratio with severe radiation-induced mucositis i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480102
BMC Cancer; Kawashita Y, Kitamura M et. al.

Sep 30th, 2021 - The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that informs clinical decisions regarding recurrence and overall survival in most epithelial cancers. Radiotherapy for head and neck cancer leads to mucositis in almost all patients and severe radiation-mucositis affects their quality of life (QOL). However, little is known about the NLR for severe mucositis. Therefor...

The role of postoperative radiotherapy in pN1 oral cavity cancer without extranodal ext...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449449
World Journal of Surgical Oncology; Tsai TY, Huang Y et. al.

Sep 19th, 2021 - The administration of postoperative radiotherapy remains controversial in pN1 oral cavity cancer patients without extranodal extension. The aim is to determine whether postoperative radiotherapy reduces the neck recurrence rate and improves the survival outcomes of pN1 patients. This study consecutively enrolled 1056 patients with newly diagnosed oral squamous cell carcinoma who underwent tumor...

Complete reversal of bilateral optic nerve infiltration from lymphoblastic leukemia usi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444571
BMC Ophthalmology; da Costa DR, Fernandes RD et. al.

Sep 17th, 2021 - Leukemic involvement of the eyes is rare, therefore, treatment relies on previous case reports. The treatment of ocular complications poses additional difficulties, because the eye is considered as a pharmacological "sanctuary" for patients with acute lymphoblastic leukemia (ALL). Therefore, radiotherapy is the main therapeutic choice; however, it might lead to many important side effects. To t...

Late-onset radiation-induced brachial plexopathy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438927
BMJ Case Reports; Attard KA, Vella JC et. al.

Sep 15th, 2021 - The late-onset variant of radiation-induced brachial plexopathy is most often seen after treatment for breast or lung cancers. It has an insidious onset, with symptoms noted years after receiving radiotherapy, and the condition gradually continues to deteriorate with time. We present the case of an elderly man who we saw in view of worsening paraesthesias and weakness of his left arm with assoc...

Evaluation of Pre-radiotherapy Sleep Disorders in Patients With Rectal or Anal Cancer.
https://doi.org/10.21873/anticanres.15251
Anticancer Research; Rades D, Kopelke S et. al.

Sep 4th, 2021 - Radiotherapy and radiochemotherapy are common treatments for rectal and anal cancer. Anticipation of treatment may cause distress and sleep disorders. This study aimed to identify risk factors for sleep disorders. In 42 patients with rectal or anal cancer scheduled for radiotherapy, 16 characteristics were analyzed for associations with pre-radiotherapy sleep disorders including age, gender, pe...

Exposure to low intensity ultrasound removes paclitaxel cytotoxicity in breast and ovar...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408969
BMC Cancer; Amaya C, Luo S et. al.

Sep 3rd, 2021 - Paclitaxel (Taxol) is a microtubule-stabilizing drug used to treat several solid tumors, including ovarian, breast, non-small cell lung, and pancreatic cancers. The current treatment of ovarian cancer is chemotherapy using paclitaxel in combination with carboplatin as a frontline agent, and paclitaxel is also used in salvage treatment as a second line drug with a dose intensive regimen followin...

Whole-body hyperthermia combined with chemotherapy and intensity-modulated radiotherapy...
https://doi.org/10.1080/02656736.2021.1971778
International Journal of Hyperthermia : the Official Jour... Zheng N, Xu A et. al.

Sep 2nd, 2021 - Several studies have reported the combination of intracavity or cervical lymph node hyperthermia with chemoradiotherapy (CRT) to improve clinical outcomes in nasopharyngeal carcinoma (NPC), but the combination with whole-body hyperthermia (WBH) for treating NPC is unexplored. We aimed to assess the efficacy of the combination of radiotherapy, chemotherapy and WBH in patients with locoregionally...

Biological consequences of cancer radiotherapy in the context of oral squamous cell car...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390213
Head & Face Medicine; Feller G, Khammissa RAG et. al.

Aug 28th, 2021 - Approximately 50% of subjects with cancer have been treated with ionizing radiation (IR) either as a curative, adjuvant, neoadjuvant or as a palliative agent, at some point during the clinical course of their disease. IR kills cancer cells directly by injuring their DNA, and indirectly by inducing immunogenic cell killing mediated by cytotoxic T cells; but it can also induce harmful biological ...

Long-term survival of patients with mantle cell lymphoma after autologous haematopoieti...
https://doi.org/10.1016/S2352-3026(21)00195-2
The Lancet. Haematology; Zoellner AK, Unterhalt M et. al.

Aug 28th, 2021 - Autologous haematopoietic stem-cell transplantation (HSCT) in first remission is the current standard treatment in fit patients with mantle cell lymphoma. In this long-term follow-up study, we aimed to evaluate the efficacy of autologous HSCT versus interferon alfa maintenance after chemotherapy without or with rituximab in patients with primary advanced-stage mantle cell lymphoma. We did a pos...

Cutoff point of neutrophil-to-lymphocyte ratio for predicting survival in nasopharyngea...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389933
Medicine Setakornnukul J, Chanvimalueng W et. al.

Aug 28th, 2021 - Neutrophil-to-lymphocyte ratio (NLR) was reported as an independent prognostic factor in many studies, but its cutoff point was not yet concluded. We set forth to prove and validate cutoff point of NLR as a poor prognostic factor for overall survival (OS) in nonmetastatic nasopharyngeal carcinoma (NPC) patients.Retrospective cohort of nonmetastatic NPC adult patients treated with intensity-modu...

Neuroblastoma xenograft models demonstrate the therapeutic potential of 177Lu-octreotate.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386073
BMC Cancer; Romiani A, Spetz J et. al.

Aug 27th, 2021 - Neuroblastoma (NB) is one of the most frequently diagnosed tumors in infants. NB is a neuroendocrine tumor type with various characteristics and features, and with diverse outcome. The most malignant NBs have a 5-year survival rate of only 40-50%, indicating the need for novel and improved treatment options. 177Lu-octreotate is routinely administered for treatment of neuroendocrine tumors overe...

Influence of high tissue-absorbed dose on anti-thyroid antibodies in radioiodine therap...
https://doi.org/10.17219/acem/137779
Advances in Clinical and Experimental Medicine : Official... Listewnik MH, Piwowarska-Bilska H et. al.

Aug 22nd, 2021 - The results of radioactive iodine (RAI) treatment for Graves' disease (GD) are related to the choice of diagnostic and dosimetry protocols, the steroid protection used, and the subsequent 131I dose. The effect of a high tissue-absorbed dose on the level of anti-thyroid antibodies (ATA) has been rarely considered. To estimate the effect of the first RAI therapy with a dose of 250 Gy on anti-thyr...

Tumor treating fields combined with a poly (adenosine diphosphate-ribose) polymerase in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381428
The Journal of International Medical Research; Wang Z, Ren Y et. al.

Aug 20th, 2021 - A 57-year-old woman was diagnosed with IDH-wildtype (IDHwt) astrocytoma (World Health Organization grade II) with the molecular characteristics of glioblastoma. She underwent concurrent radiotherapy and chemotherapy according to the Stupp protocol in combination with a multi-target antiangiogenic drug and additional intrathecal chemotherapy using methotrexate. During treatment, the patient's tu...

Central nervous system metastases: a rare presentation of nasopharyngeal carcinoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372796
BMJ Case Reports; Abrar S, Ali N et. al.

Aug 19th, 2021 - We report a case of a male patient. He presented with nasal obstruction and epistaxis. The MRI of the brain showed a mass in the nasopharynx and enlarged cervical lymph nodes. Besides this, there was an extra-axial, dural-based lesion in brain and subcentimetre nodules in both lungs. He received induction chemotherapy followed by chemoradiation therapy to the primary site and dural-based metast...

Photobiomodulation Therapy in Head and Neck Cancer-Related Lymphedema: A Pilot Feasibil...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366198
Integrative Cancer Therapies; Deng J, Lukens JN et. al.

Aug 14th, 2021 - Lymphedema is a common debilitating late effect among patients post-head and neck cancer (HNC) treatment. Head and neck lymphedema was associated with symptom burden, functional impairment, and decreased quality of life. The objective of this study was to determine the feasibility and potential efficacy of the use of photobiomodulation (PBM) therapy for head and neck lymphedema, symptom burden,...