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How to avoid the perils of uveitis diagnostic management

Jan 16th, 2022 - WAIKOLOA, Hawaii — It is important for physicians to consider “the perils that dwell” in the diagnostic management of patients with uveitis, Steven Yeh, MD, said during a presentation at Hawaiian Eye 2022. “With these patients being very complex oftentimes, we really just don’t want to miss something,” Yeh said. To better identify “the pearls amongst the perils” in uveitis diagnosis, it is impo...

RECOVER Researchers Express Hope and Frustration in Their Study of Long COVID
MedPage Today; DePeau-Wilson M.

Jul 23rd, 2022 - Slow enrollment has led to simmering frustrations over the progress and potential of the NIH's RECOVER Initiative, the research consortium focused on studying post-acute sequelae of SARS-CoV-2, or long COVID, according to researchers and leaders within the initiative. The RECOVER Initiative was designed to support research on long COVID across the U.S., including among every group of people ...

Natural History and Development of Spondyloarthritis

Aug 4th, 2022 - The purpose of this protocol is to study the natural history of spondyloarthritis (SpA) in children and adults. Spondyloarthritis encompasses a spectrum of immune-mediated inflammatory diseases that exhibit overlapping features, but differ from other types of inflammatory arthritis in genetic predisposition, pathogenesis, and outcome. Ankylosing spondylitis (AS), the most common form of SpA, fr...

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

Fluconazole - fluconazole tablet-REMEDYREPACK INC.

Dec 30th, 2022 - Fluconazole tablets are indicated for the treatment of: Vaginal candidiasis (vaginal yeast infections due to Candida). Oropharyngeal and esophageal candidiasis. In open noncomparative studies of relatively small numbers of patients, fluconazole tablets were also effective for the treatment of Candida urinary tract infections, peritonitis, and systemic Candida infections including candidemia, di...

How effective is the monkeypox vaccine? Scientists scramble for clues as trials ramp up
Science Kupferschmidt K.

Aug 10th, 2022 - When monkeypox suddenly started spreading globally in May, the world was fortunate in one respect: a vaccine was available. MVA, originally developed by Bavarian Nordic as a smallpox vaccine, was already licensed for monkeypox in Canada and the United States. EU regulators have since followed suit. Vaccine supplies are limited, and no doses have been shared with countries in Africa that have lo...

Impact of SARS-CoV-2 Omicron on Rapid Antigen Testing Developed for Early-Pandemic SARS-CoV-2 Variants
Microbiology Spectrum; Leuzinger K, .

Aug 9th, 2022 - Rapid antigen tests (RATs) are widely used for point-of-care or self-testing to identify SARS-CoV-2 (SCoV2), but currently circulating Omicron variants may impair detection. In this study, we prospectively evaluated the Roche-SARS-CoV-2-Antigen and Acon-FlowFlex-SARS-CoV-2-Antigen in 150 consecutively collected nasopharyngeal patient swabs (50 SCoV2 RNA undetectable; 100 SCoV2 Omicron BA.1).

Major test of first possible Lyme vaccine in 20 years begins
Associated Press; Neergaard L, Lum S.

Aug 8th, 2022 - DUNCANSVILLE, Pa. (AP) — Researchers are seeking thousands of volunteers in the U.S. and Europe to test the first potential vaccine against Lyme disease in 20 years -- in hopes of better fighting the tick-borne threat.

Pfizer and Valneva Initiate Phase 3 Study of Lyme Disease Vaccine Candidate VLA15
Pfizer Inc.

Aug 8th, 2022 - NEW YORK & SAINT-HERBLAIN, France--(BUSINESS WIRE)-- Pfizer Inc. (NYSE: PFE) and Valneva SE (Nasdaq: VALN; Euronext Paris: VLA) today announced the initiation of a Phase 3 clinical study, Vaccine Against Lyme for Outdoor Recreationists (VALOR) (NCT05477524), to investigate the efficacy, safety and immunogenicity of their investigational Lyme disease vaccine candidate, VLA15.

Long COVID: which symptoms can be attributed to SARS-CoV-2 infection?
The Lancet; Brightling CE, Evans RA.

Aug 6th, 2022 - Mortality rates following SARS-CoV-2 infection have decreased as a consequence of public health policies, vaccination, and acute antiviral and anti-inflammatory therapies.1 However, in the wake of the pandemic, post-acute sequelae of COVID-19, or long COVID, has emerged: a chronic illness in people who have ongoing multidimensional symptomatology and disability weeks to years after the initial ...

HHS declares U.S. monkeypox outbreak public health emergency
American Hospital Association

Aug 4th, 2022 - As the number of U.S. monkeypox cases continues to grow, Health and Human Services Secretary Xavier Becerra today declared the outbreak a public health emergency. “We're prepared to take our response to the next level in addressing this virus, and we urge every American to take monkeypox seriously and to take responsibility to help us tackle this virus,” Becerra said in announcing the action.

Breakthrough infections after post-exposure vaccination against Monkeypox
Medrxiv Thy M, .

Aug 4th, 2022 - A third-generation smallpox vaccine was recommended in France for individuals who had a high-risk contact with a PCR-confirmed Monkeypox patient. We aimed to describe the outcomes of high-risk contacts receiving third-generation smallpox vaccine as an early postexposure ring vaccination (EPRV) especially tolerance and potential breakthrough infections after the first dose.

Duration of Symptoms and Association With Positive Home Rapid Antigen Test Results After Infection With SARS-CoV-2
JAMA Network Open; Cosimi LA, Kelly C et. al.

Aug 3rd, 2022 - Current US Centers for Disease Control and Prevention COVID-19 guidance for nonimmunocompromised individuals allows ending isolation after 5 days if the individual is asymptomatic or afebrile with improving symptoms.1 Culturable virus, currently the best proxy for transmissibility, is reported after day 5.2 It has been proposed that rapid antigen tests (RATs) might assist in determining isolati...

Omicron-associated changes in SARS-CoV-2 symptoms in the United Kingdom
Clinical Infectious Diseases; Vihta DK, .

Aug 3rd, 2022 - The SARS-CoV-2 Delta variant has been replaced by the highly transmissible Omicron BA.1 variant, and subsequently by Omicron BA.2. It is important to understand how these changes in dominant variants affect reported symptoms, while also accounting for symptoms arising from other co-circulating respiratory viruses.

Heart disease after COVID: what the data say
Nature Sadiik SM.

Aug 2nd, 2022 - Some studies suggest that the risk of cardiovascular problems, such as a heart attack or stroke, remains high even many months after a SARS-CoV-2 infection clears up. Researchers are starting to pin down the frequency of these issues and what is causing the damage.

Association of Receiving a Fourth Dose of the BNT162b Vaccine With SARS-CoV-2 Infection Among Health Care Workers in Israel
JAMA Network Open; Cohen MJ, Oster Y et. al.

Aug 2nd, 2022 - In December 2021, the fifth COVID-19 wave started in Israel, caused mostly by the Omicron variant and affecting the unvaccinated and vaccinated populations.1,2 Israel was the first country to administer a third vaccine dose to the entire adult population, beginning in August 2021. Ninety percent of adults in Israel, including more than 95% of health care workers (HCWs),3 received 3 doses of the...

Three types of long-COVID for people experiencing symptoms for 12 weeks or more
King's College London;

Aug 1st, 2022 - The pre-print, published today on MedrXiv, also identifies patterns among people infected with the wild-type, the first strain of SARS-CoV-2, and Delta and Alpha variants, among vaccinated and unvaccinated individuals. Researchers from King’s analysed data of 1,459 individuals who have experienced ongoing symptoms for longer than 84 days, known clinically as post-covid syndrome or long COVID...

How Well Does the Monkeypox Vax Work? No One Knows for Sure — Health officials hang hopes on Jynneos, but vaccine not yet proven to protect against infection
MedPage Today; Dotinga R.

Aug 1st, 2022 - Across an American gay male community worried about catching monkeypox, one message suggests this is all temporary: A few months of sexual caution plus vaccination will usher in a care-free autumn.

Profiling post-COVID syndrome across different variants of SARS-CoV-2
Medrxiv Canas LS, .

Jul 31st, 2022 - Background Self-reported symptom studies rapidly increased our understanding of SARS-CoV-2 during the pandemic and enabled the monitoring of long-term effects of COVID-19 outside the hospital setting. It is now evident that post-COVID syndrome presents with heterogeneous profiles, which need characterisation to enable personalised care among the most affected survivors. This study describes pos...

Fast-evolving COVID variants complicate vaccine updates
Nature Callaway E.

Jul 27th, 2022 - As countries brace for another Omicron wave driven by the variants BA.4 and BA.5, calls to update COVID-19 vaccines are growing louder. Existing vaccines based on the version of the virus SARS-CoV-2 that emerged in Wuhan, China, in late 2019 are a poor match to current Omicron strains. As a result, the vaccines now offer only short-lived protection from infection — although they seem to be h...