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About 19,223 results

Consolidation of Tumorous Mandibular Ramus Defect During Denosumab Treatment for Rapidl...
https://doi.org/10.21873/anticanres.15324
Anticancer Research; Friedrich RE, Madani E

Oct 2nd, 2021 - Pharmacological inhibition of osteoclast activity is an essential component of oncological therapy for patients with bone metastases. In rare cases, medication-related osteonecrosis of the jaws (MRONJ) is observed. MRONJ can cause bone defects not inferior to primary or metastatic jaw neoplasms. Oral examination of patients on osteoclast-inhibiting medication aims to identify risk factors at an...

Intrahepatic Cholangiocarcinoma Coexisting With Multiple Bile Duct Adenoma Treated as L...
https://doi.org/10.21873/anticanres.15344
Anticancer Research; Oda E, Yamamura K et. al.

Oct 2nd, 2021 - Bile duct adenomas (BDA) may be precursor lesions of small duct-type, including mass-forming type intrahepatic cholangiocarcinoma (ICC). A 68-year-old woman was transferred to our facility for the treatment of a liver tumor, possibly metastasized from a pancreatic neuroendocrine tumor. Finally, two liver tumors were resected and histopathologically diagnosed as "BDA" and "ICC with a BDA-like co...

The Thioredoxin Reductase Inhibitor Auranofin Suppresses Pulmonary Metastasis of Osteos...
https://doi.org/10.21873/anticanres.15308
Anticancer Research; Kinoshita H, Shimozato O et. al.

Oct 2nd, 2021 - Auranofin (AUR), a thioredoxin reductase (TXNRD) inhibitor, shows anticancer activity against several cancers. This study investigated the effects of AUR on the local progression and pulmonary metastasis of osteosarcoma (OS). Publicly available expression cohorts were analysed to study the relationship between TXNRD-2 expression and the survival of patients with OS. The murine OS cell line LM8 ...

Symptom Outcomes of Cancer Patients With Clival Metastases Treated With Radiotherapy: A...
https://doi.org/10.21873/anticanres.15314
Anticancer Research; Sturgis R, Mack A et. al.

Oct 2nd, 2021 - To describe clinical features, radiotherapy (RT), and symptom outcomes in cancer patients with cranial nerve palsies associated with clival metastases. This is a retrospective review of patients with primary metastatic cancers who developed clival metastases and received RT (2000-2020). Of the 44 patients with primary cancers (manly breast, prostate and multiple myeloma cancers) and distal cliv...

Vitreoretinal lymphoma occurring after systemic chemotherapy for primary conjunctival d...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483852
Medicine Niidome E, Usui Y et. al.

Oct 2nd, 2021 - Ocular adnexal lymphoma and vitreoretinal lymphoma are rare forms of non-Hodgkin lymphoma. They are regarded as distinct disease entities due to the differences in molecular mechanism, management, and outcome. We present a rare case of conjunctival diffuse large B cell lymphoma (DLBCL) that developed to vitreoretinal lymphoma after systemic chemotherapy. A 60-year-old man presented with a left ...

EMMPRIN expression is associated with metastatic progression in osteosarcoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474954
BMC Cancer; Kim HS, Kim HJ et. al.

Sep 28th, 2021 - Extracellular matrix metalloproteinase inducer (EMMPRIN), a cell-surface glycoprotein, is overexpressed in several cancer types. EMMPRIN induces a metastatic phenotype by triggering the production of matrix metalloproteinase proteins (MMPs) such as MMP1 and MMP2, and vascular endothelial growth factor (VEGF) in cancer cells and the surrounding stromal cells. The purpose of this study was to inv...

The risk and prognostic factors for brain metastases in esophageal cancer patients: an ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465786
BMC Cancer; Cheng S, Yang L et. al.

Sep 27th, 2021 - Brain metastases were rare in esophageal cancer patients. Using the Surveillance, Epidemiology, and End Results (SEER) database, the present study investigated the incidence, risk and prognostic factors of brain metastases in esophageal cancer patients. Retrieving esophageal cancer patients diagnosed between 2010 and 2018 from the SEER database, univariable and multivariable logistic and cox re...

Comparative efficacy and safety for second-line treatment with ramucirumab, regorafenib...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462645
Medicine Chen J, Wang J et. al.

Sep 25th, 2021 - The present network meta-analysis was conducted to perform an indirect comparison among ramucirumab, regorafenib, and cabozantinib in patients with advanced hepatocellular carcinoma (HCC) progressed on sorafenib treatment. A systematic review through Medline, Embase, and Cochrane library was developed, with eligible randomized clinical trials been included. Hazard ratios (HRs) including progres...

Multimodal and systemic therapy with cabozantinib for treatment of recurrent hepatocell...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462617
Medicine Mahn R, Sadeghlar F et. al.

Sep 25th, 2021 - Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) remains a major therapeutic challenge. In recent years, new molecular-targeted therapies, such as cabozantinib, have been approved for the treatment of advanced HCC. However, clinical experience with these new drugs in the treatment of HCC in the LT setting is very limited. In 2003, a 36-year-old woman was referred to...

Pancreatic Cancer: A Review.
https://doi.org/10.1001/jama.2021.13027
JAMA Park W, Chawla A et. al.

Sep 22nd, 2021 - Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon cancer, with approximately 60 430 new diagnoses expected in 2021 in the US. The incidence of PDAC is increasing by 0.5% to 1.0% per year, and it is projected to become the second-leading cause of cancer-related mortality by 2030. Effective screening is not available for PDAC, and most patients present with locally advanced (30%-35...

Effect of Camrelizumab vs Placebo Added to Chemotherapy on Survival and Progression-Fre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441593
JAMA Luo H, Lu J et. al.

Sep 15th, 2021 - Standard first-line therapy for advanced or metastatic esophageal carcinoma is chemotherapy, but the prognosis remains poor. Camrelizumab (an anti-programmed death receptor 1 [PD-1] antibody) showed antitumor activity in previously treated advanced or metastatic esophageal squamous cell carcinoma. To evaluate the efficacy and adverse events of camrelizumab plus chemotherapy vs placebo plus chem...

Intrabony mandibular metastases caused by papillary thyroid carcinoma masquerading as a...
https://doi.org/10.1308/rcsann.2020.7091
Annals of the Royal College of Surgeons of England; Wareing J, Dawoud B et. al.

Sep 1st, 2021 - Papillary carcinoma is the most common type of thyroid cancer, accounting for 80-90% of cases. Distant metastasis of papillary thyroid cancer is uncommon, but when it does occur, it is most commonly to the lungs, liver and bone. Bone metastases to the mandible are rarely reported. We present a 68-year-old man who was referred due to a right parotid mass. Appropriate imaging and biopsy revealed ...

Composite Neuroblastoma Metastatic to a Lymph Node: The Novel Histopathologic Diagnosis...
https://www.ncbi.nlm.nih.gov/pubmed/34452899
Annals of Clinical and Laboratory Science; Kurtz JL, Shimada H et. al.

Aug 29th, 2021 - Composite neuroblastoma is a tumor composed of multiple tumoral clones within the neuroblastoma family. To date, establishing this unique histopathologic diagnosis has required the evaluation of the primary tumor mass. We report a case of composite neuroblastoma diagnosed by evaluation of a metastatic lymph node. One abdominal lymph node involved by tumor was evaluated in a 6-year-old boy. The ...

Long-term survival following radiofrequency ablation of lung metastases in an elderly p...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389876
Medicine Futani H, Takaki H et. al.

Aug 28th, 2021 - Recently, the number of osteosarcomas has been increasing in elderly patients due to human longevity. Lung metastases are the primary cause of death from osteosarcomas. Complete resection of lung metastases can prolong the survival. However, complete resection in elderly patients is often difficult due to high risk of operative complications. Computed tomography (CT) guided radiofrequency ablat...

Skeletal muscle metastasis from a gastrointestinal stromal tumor: A case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389935
Medicine Zhu G, Sun W et. al.

Aug 28th, 2021 - Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Common sites for metastasis are the liver and peritoneum, whereas skeletal muscle metastases are rare. A 59-year-old man with skeletal muscle metastasis was diagnosed during a period of adjuvant imatinib therapy following the recurrence of GIST of the small intestine. The patient was di...

Outcomes of Stereotactic Radiosurgery and Immunotherapy in Renal Cell Carcinoma Patient...
https://doi.org/10.1097/COC.0000000000000849
American Journal of Clinical Oncology; Uezono H, Nam D et. al.

Aug 26th, 2021 - The impact of immunotherapy and stereotactic radiosurgery (SRS) in treatment of brain metastases (BM) from renal cell carcinoma (RCC) has not been well investigated. Forty-eight patients with 372 RCC BM were treated with SRS and divided into those ever treated with immunotherapy versus those who never received immunotherapy. Survival and local control (LC) outcomes were studied. χ2 and Mann-Whi...

Case reports of robot-assisted laparoscopic radical nephrectomy and inferior vena cava ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376354
Medicine Ma S, Jia W et. al.

Aug 21st, 2021 - Renal cell carcinoma is one common type of urologic cancers. It has tendencies to invade into the inferior vena cava (IVC) and usually requires an open surgery procedure. High rates of operative complications and mortality are usually associated with an open surgery procedure. The recently emerged robot-assisted laparoscopic radical nephrectomy (RAL-RN) and IVC tumor thrombectomy have shown to ...

Expression of ANCR in nasopharyngeal carcinoma patients and its clinical significance.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376304
Medicine Guo C, Ma X et. al.

Aug 21st, 2021 - Anti-differentiation non-coding RNA (ANCR), a long non-coding RNA, is involved in the development, progression and metastasis of various human cancers. However, its clinical significance in nasopharyngeal carcinoma (NPC) still remains unknown. This study aimed to investigate ANCR expression and its clinical significance in NPC.Totally, 96 NPC tissues and 24 non-cancerous nasopharyngeal mucosa t...

Durable response to immunotherapy plus chemotherapy in a patient with untreated, brain-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294870
Medicine Nong J, Gu Y et. al.

Aug 17th, 2021 - Epidermal growth factor receptor (EGFR) 20 exon insertion is the second most common EGFR aberrations in non-small cell lung cancer (NSCLC). Despite some novel EGFR inhibitors, clinically obtainable management for this subset of patients remains an unmet need. there are no previous reports of upfront combination therapy with immunotherapy and chemotherapy for lung adenocarcinoma with brain metas...

Bilateral adrenal metastasis of renal cell carcinoma 4 years after radical nephrectomy:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341217
Medicine Li Y, Ji Z et. al.

Aug 17th, 2021 - Renal cell carcinoma (RCC) almost metastasizes to every organ, the possibility of adrenal metastasis is relatively low in patients that have undergone radical nephrectomy, only a few cases of bilateral adrenal metastasis are reported on literature. Although surgical treatment of metastases from RCC is preferred and contributes to the rate of survival, it is considered challenging to manage such...