Contrast Media & Molecular Imaging; Wang D, Yang Y et. al.
May 3rd, 2022 - Our study aims to compare the diagnostic value of 18F-NaF positron emission tomography-computed tomography (PET/CT), 18F-NaF PET, and planar 99mTc-MDP bone scintigraphy for detection of bone metastases in patients with newly diagnosed nasopharyngeal carcinoma (NPC). Our study retrospectively analyzed 58 patients with pathologically proven NPC. They all underwent both 18F-NaF PET/CT and planar 9...
Anticancer Research; Tate S, Nishikimi K et. al.
May 1st, 2022 - Brain metastases from ovarian cancer remain rare and the appropriate treatment is unknown. We investigated survival outcomes following salvage chemotherapy before and after bevacizumab approval to evaluate the efficacy of bevacizumab in patients with brain metastasis from ovarian cancer. We investigated 23 consecutive patients with brain metastasis from ovarian cancer at our hospital between 20...
BMJ Case Reports; Campoverde LE, Batalini F et. al.
Apr 30th, 2022 - A woman in her 50s previously treated for early-stage breast cancer, parotid mucoepidermoid carcinoma and Caroli's disease was diagnosed with stage IV pancreatic ductal adenocarcinoma (PDAC) metastatic to the liver and was found to harbour a BRCA1 germline mutation. She had palliative chemotherapy, initially with 5-fluorouracil, leucovorin, irinotecan and oxaliplatin, and then FOLFIRI and capec...
Current Oncology (Toronto, Ont.); El Ouadih Y, Pereira B et. al.
Apr 22nd, 2022 - (1) Background: Glioblastoma multiforme (GBM) shows complex mechanisms of spreading of the tumor cells, up to remote areas, and little is still known of these mechanisms, thus we focused on MRI abnormalities observable in the tumor and the brain adjacent to the lesion, up to the contralateral hemisphere, with a special interest on tensor diffusion imaging informing on white matter architecture;...
Journal of Experimental & Clinical Cancer Research : CR; Sun Y, Qian Y et. al.
Apr 17th, 2022 - Metastasis is the leading cause of mortality in human cancers, including esophageal squamous cell carcinoma (ESCC). As a pro-inflammatory cytokine, IL-32 was reported to be a poor prognostic factor in many cancers. However, the role of IL-32 in ESCC metastasis remains unknown. ESCC cells with ectopic expression or knockdown of IL-32 were established and their effects on cell motility were detec...
The Journal of International Medical Research; Lin CW, Peng SL et. al.
Apr 8th, 2022 - Metastatic tumours to the ovary comprise 10-25% of ovarian malignancies and may originate from various primary sites. Here, the case of a 49-year-old female patient who presented with periumbilical nodules and abdominal bloating is reported. She was found to have bilateral ovarian tumours with peritoneal carcinomatosis and ascites. Primary ovarian cancer was suspected while no contributory gast...
BMC Women's Health; Fujimori M, Takahashi T et. al.
Apr 7th, 2022 - Epithelial ovarian cancer is the most frequent gynecologic malignancy; it has a poor prognosis and often occurs bilaterally. Most cases of synchronous bilateral ovarian cancer (SBOC) are metastases from the other ovary, while bilateral primary ovarian cancer is rare. The patient was a 47-year-old Japanese woman with a complaint of abdominal pain for 1 month. Imaging results revealed bilateral o...
BMJ Case Reports; De Jesus O, Pellot Cestero JE et. al.
Apr 3rd, 2022 - Choriocarcinoma is a highly malignant tumour emerging from the syncytiotrophoblast divided into gestational and non-gestational presentations. Primary choriocarcinoma of the mediastinum is rare. Metastases to the brain often occur; however, brainstem involvement has not been reported for non-gestational choriocarcinoma. We described a middle-aged man who developed a complete left oculomotor ner...
BMC Gastroenterology; Higuchi R, Ono H et. al.
Mar 30th, 2022 - Gallbladder cancer (GBC) with liver metastasis is considered unresectable. However, there have been infrequent reports of long-term survival in patients with GBC and liver metastases. Therefore, we examined the characteristics of long-term survivors of gallbladder cancer with liver metastasis. A retrospective multicenter study of 462 patients with GBC (mean age, 71 years; female, 51%) was perfo...
The Oncologist; Park HJ, Qin L et. al.
Mar 30th, 2022 - The treatment responses of immune checkpoint inhibitors in metastatic renal cell carcinoma (mRCC) vary, requiring reliable prognostic biomarkers. We assessed the prognostic ability of computed tomography (CT) texture analysis in patients with mRCC treated with programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitors. Sixty-eight patients with mRCC treated with PD-1/PD-L1 ...
BMC Cancer; Yang F, Sun Z et. al.
Mar 24th, 2022 - Several studies have documented the key role of microRNAs (miRNAs) in esophageal squamous cell carcinoma (ESCC). Although the expression of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene and miR-106b-5p are reportedly linked to cancer progression, their underlying mechanisms in ESCC remain unclear. mRNA and miRNA expression in ESCC tissues and cells were analyzed using RT-qPCR. Luciferas...
BMJ Case Reports; Gatsinga R, Tan YG et. al.
Mar 23rd, 2022 - We describe the case of a metastatic penile tumour of hepatocellular origin treated with surgical resection.
Critical Reviews in Oncology/hematology; Macfie R, Berger Y et. al.
Mar 19th, 2022 - Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer, which commonly metastasizes to the liver. The current standard of care for metastatic PDAC is systemic chemotherapy, however there are limited emerging data regarding surgical resection of pancreatic oligometastases in select patients. Here we review the literature addressing resection of PDAC liver oligometastases.
Orthopaedic Surgery; Xu G, Wu H et. al.
Mar 17th, 2022 - Based on a large public cohort, we aimed to investigate the prevalence of distant metastases in patients with osteosarcoma, to evaluate the survival of patients with different metastases and to reveal the related risk and prognostic factors for distant metastases. The information of osteosarcoma patients with or without distant metastases was retrospectively extracted from the Surveillance, Epi...
BMJ Open; Hazewinkel AD, Lancia C et. al.
Mar 6th, 2022 - Investigating the effect of prognostic factors in a multistate framework on survival in a large population of patients with osteosarcoma. Of interest is how prognostic factors affect different disease stages after surgery, with stages of local recurrence (LR), new metastatic disease (NM), LR+NM, secondary malignancy, a second NM, and death. An open-label, international, phase 3 randomised contr...
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Current Oncology Reports; Chen YW, Rini BI
Mar 6th, 2022 - Four immuno-oncology (IO)-based combinations have demonstrated overall survival benefit as frontline treatment of metastatic clear cell renal cell carcinoma (mccRCC). Choosing among the available combinations depends on treating physician's interpretation of existing data without level I evidence to inform choice of therapy. Landmark trials of mccRCC are reviewed and perspective on treatment op...
Journal for Immunotherapy of Cancer; Sousa LG, McGrail DJ et. al.
Mar 5th, 2022 - Vaccination against COVID-19 is critical for immuno-compromised individuals, including patients with cancer. Systemic reactogenicity, a manifestation of the innate immune response to vaccines, occurs in up to 69% of patients following vaccination with RNA-based COVID-19 vaccines. Tumor regression can occur following an intense immune-inflammatory response and novel strategies to treat cancer re...
BMJ Case Reports; Quigley D, O Donnell R et. al.
Mar 5th, 2022 - Pulmonary lymphangitis carcinomatosis is a complication of malignancy with a poor prognosis. We describe an unusual case in which it caused ventilatory failure and unfortunately death in a previously well male in his 70s. Abnormal chest imaging led to a wide differential diagnosis with Bronchoscopy confirming malignant cells. MRI of his pelvis and biopsy was done diagnosis of metastatic leiomyo...
BMC Pulmonary Medicine; Wang Q, Tan X et. al.
Mar 5th, 2022 - The systemic immune-inflammation index (SII) has recently emerged as a predictor of survival in non-small cell lung cancer patients. There is also tight correlation between radiotherapy and immune status, and brain metastases (BM) radiotherapy is an important treatment in patients with BM from lung adenocarcinoma harboring epidermal growth factor receptor (EGFR) mutations. Hence, this study aim...
Anticancer Research; Tashiro Y, Aoki T et. al.
Feb 28th, 2022 - Radiofrequency ablation (RFA) is used to treat primary and metastatic tumors in the liver. However, local recurrence after RFA is frequent and subsequent salvage hepatectomy is often ineffective due to difficulty in visualization of tumor margins. In the present retrospective clinical trial, seven patients from the Department of General and Gastro-enterological Surgery, Showa University School ...