About 456,140 results

Cerebrospinal Fluid Offers Clues to Post-COVID ‘Brain Fog’
UCSF Leigh S.

Jan 18th, 2022 - Some patients who develop new cognitive symptoms after a mild bout of COVID-19 have abnormalities in their cerebrospinal fluid similar to those found in people with other infectious diseases. The finding may provide insights into how SARS-CoV-2 impacts the brain.

Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain
BioRxiv Fernandez-Castaneda A, .

Jan 10th, 2022 - Survivors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection frequently experience lingering neurological symptoms, including impairment in attention, concentration, speed of information processing and memory. This long-COVID cognitive syndrome shares many features with the syndrome of cancer therapy-related cognitive impairment (CRCI).

Biomarkers of Post-COVID Depression
Journal of Clinical Medicine; Lorkiewicz P

Sep 14th, 2021 - The COVID-19 pandemic is spreading around the world and 187 million people have already been affected. One of its after-effects is post-COVID depression, which, according to the latest data, affects up to 40% of people who have had SARS-CoV-2 infection. A very important issue for the mental health of the general population is to look for the causes of this complication and its biomarkers.

Intranasal inhibitor blocks omicron and other variants of SARS-CoV-2
Research Square; Mäkelä AR, .

Dec 28th, 2021 - The emergence of the SARS-CoV-2 Omicron variant capable of escaping neutralizing antibodies emphasizes the need for prophylactic strategies to complement vaccination in fighting the COVID-19 pandemic. Nasal epithelium is rich in the ACE2 receptor and important for SARS-CoV-2 transmission by supporting early viral replication before seeding to the lung1. Intranasal administration of SARS-CoV-2 n...

CDC Updates and Shortens Recommended Isolation and Quarantine Period for General Population
Centers for Disease Control and Prevention (CDC)

Dec 27th, 2021 - Given what we currently know about COVID-19 and the Omicron variant, CDC is shortening the recommended time for isolation from 10 days for people with COVID-19 to 5 days, if asymptomatic, followed by 5 days of wearing a mask when around others. The change is motivated by science demonstrating that the majority of SARS-CoV-2 transmission occurs early in the course of illness, generally in the 1-...

The Omicron variant is highly resistant against antibody-mediated neutralization – implications for control of the COVID-19 pandemic
Cell Hoffmann M, .

Dec 23rd, 2021 - The rapid spread of the SARS-CoV-2 Omicron variant suggests that the virus might become globally dominant. Further, the high number of mutations in the viral spike-protein raised concerns that the virus might evade antibodies induced by infection or vaccination. Here, we report that the Omicron spike was resistant against most therapeutic antibodies but remained susceptible to inhibition by Sot...

Outbreak caused by the SARS-CoV-2 Omicron variant in Norway, November to December 2021
Eurosurveillance Brandal LT, .

Dec 15th, 2021 - On 30 November 2021 the Norwegian Institute of Public Health (NIPH) was notified by a local laboratory in Oslo of a coronavirus disease (COVID-19) case with suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (VOC) (Phylogenetic Assignment of Named Global Outbreak Lineages (Pangolin) designation B.1.1.529 BA.1) infection [1]. The laboratory provided...

Latest on Omicron Variant and COVID-19 Vaccine Protection
NIH Director's Blog; Collins FS.

Dec 14th, 2021 - There’s been great concern about the new Omicron variant of SARS-CoV-2, the coronavirus that causes COVID-19. A major reason is Omicron has accumulated over 50 mutations, including about 30 in the spike protein, the part of the coronavirus that mRNA vaccines teach our immune systems to attack. All of these genetic changes raise the possibility that Omicron could cause breakthrough infections in...

The epidemiological relevance of the COVID-19-vaccinated population is increasing
The Lancet; Kampf G.

Dec 1st, 2021 - High COVID-19 vaccination rates were expected to reduce transmission of SARS-CoV-2 in populations by reducing the number of possible sources for transmission and thereby to reduce the burden of COVID-19 disease. Recent data, however, indicate that the epidemiological relevance of COVID-19 vaccinated individuals is increasing. In the UK it was described that secondary attack rates among househol...

Call to apply a consistent scale in public COVID-19 reporting
The Lancet; Kampf G.

Dec 1st, 2021 - The Robert Koch-Institute in Germany regularly reports about the national COVID-19 situation and population-based vaccination level. But a consistent scale is not used. A person is classified as “COVID-19 case” whenever tested positive for SARS-CoV-2 irrespective of any symptoms. But symptomatic fully vaccinated COVID-19 patients are described as “probable breakthrough infection”

Where did ‘weird’ Omicron come from?
Science Kupferschmidt K.

Dec 1st, 2021 - Since South African scientists announced last week they had identified an unsettling new variant of SARS-CoV-2, the world has anxiously awaited clues about how it might change the trajectory of the pandemic. But as big a mystery—if less urgent—is where and how Omicron evolved, and what lessons its emergence holds for avoiding future dangerous variants.

Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants
BioRxiv Tada T, Zhou H et. al.

Jul 19th, 2021 - The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible decreases in vaccine efficacy. Here, neutralizing antibody titers elicited by mRNA-based and an adenoviral vector-based vaccine against variant pseudotyped viruses were compared.

SARS-CoV-2 vaccine protection and deaths among US veterans during 2021
Science Cohn BA, .

Nov 4th, 2021 - The messenger RNA vaccines BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna) and the viral vector vaccine JNJ-78436735 (Janssen) have effectively prevented clinically significant disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since their rollout in the U.S. in late 2020 (1, 2).

In Covid-19 vaccinated people, those with prior infection likely to have more antibodies

Nov 1st, 2021 - In what is believed to be one of the largest studies of its kind, Johns Hopkins Medicine researchers have shown that antibody levels against SARS-CoV-2 (the COVID-19 virus) stay more durable — that is, remain higher over an extended period of time — in people who were infected by the virus and then received protection from two doses of messenger RNA (mRNA) vaccine compared with those who only g...

Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study
The Lancet Infectious Diseases; Singanayagam A, .

Oct 29th, 2021 - The SARS-CoV-2 delta (B.1.617.2) variant is highly transmissible and spreading globally, including in populations with high vaccination rates. We aimed to investigate transmission and viral load kinetics in vaccinated and unvaccinated individuals with mild delta variant infection in the community.

Is It Ethical to Turn Away New Patients Who Refuse COVID-19 Vaccinations?
Medscape Wilner AN, Pies RW.

Oct 20th, 2021 - The ongoing pandemic has raised complex, often troubling ethical issues for medical professionals. In addition to the enormous emotional and logistical burdens imposed by caring for those with COVID-19, there is now the stress and ambivalence in dealing with patients who have refused vaccination against SARS-CoV-2 infection. In this dialogue, neurologist Dr Andrew N. Wilner and psychiatrist/...

Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report
Medrxiv Atmar RL, .

Oct 13th, 2021 - Background: While Coronavirus disease 2019 (Covid-19) vaccines are highly effective, breakthrough infections are occurring. Booster vaccinations have recently received emergency use authorization (EUA) for certain populations but are restricted to homologous mRNA vaccines. We evaluated homologous and heterologous booster vaccination in persons who had received an EUA Covid-19 vaccine regimen.

Semglee Pen Recall; Prader-Willi Syndrome Drug Rejected; Resilience Good for Sex

Jan 23rd, 2022 - The FDA announced that Mylan Pharmaceuticals is voluntarily recalling a batch of its non-interchangeable insulin glargine injection (Semglee) prefilled pens for possible missing labels. In other FDA news, the agency turned down Levo Therapeutics' investigational intranasal form of carbetocin (LV-101), which was developed as a treatment for hyperphagia, anxiety, and distress associated with Prad...

Probable Transmission of SARS-CoV-2 Omicron Variant in Quarantine Hotel, Hong Kong, China, November 2021

Jan 23rd, 2022 - A new variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), B.1.1.529, was identified in Botswana and South Africa in early November 2021 and was designated as variant of concern (VOC) Omicron by the World Health Organization on November 26, 2021 (1). As of December 1, 2021, ≈220 sequences were available on GISAID (https://www.gisaid.org), and this variant has been detected i...

Molecular characterization and investigation of the role of genetic variation in phenot...
Genetics in Medicine : Official Journal of the American C... Meester JAN, Peeters S et. al.

Jan 22nd, 2022 - In a large cohort of 373 pediatric patients with Marfan syndrome (MFS) with a severe cardiovascular phenotype, we explored the proportion of patients with MFS with a pathogenic FBN1 variant and analyzed whether the type/location of FBN1 variants was associated with specific clinical characteristics and response to treatment. Patients were recruited on the basis of the following criteria: aortic...