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About 20,310 results

Diagnostic performance of mycological tests for invasive pulmonary aspergillosis in non...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438090
BMJ Open; Liu M, Cheng G et. al.

Aug 30th, 2022 - Increasing numbers of patients with non-haematological diseases are infected with invasive pulmonary aspergillosis (IPA), with a high mortality reported which is mainly due to delayed diagnosis. The diagnostic capability of mycological tests for IPA including galactomannan test, (1,3)-β-D-glucan test, lateral flow assay, lateral flow device and PCR for the non-haematological patients remains un...

Validation of the German eHealth impact questionnaire for online health information use...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380659
BMC Medical Informatics and Decision Making; Sippel A, Riemann-Lorenz K et. al.

Aug 17th, 2022 - Persons with multiple sclerosis (MS) are confronted by an overwhelming amount of online health information, which can be valuable but also vary in quality and aim. Therefore, it is of great importance for developers and providers of eHealth information to understand its impact on the users. The eHealth Impact Questionnaire (eHIQ) has been developed in the United Kingdom to measure the potential...

The effectiveness of COVID-19 testing and contact tracing in a US city.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407477
Proceedings of the National Academy of Sciences of the Un... Wang X, Du Z et. al.

Aug 16th, 2022 - Although testing, contact tracing, and case isolation programs can mitigate COVID-19 transmission and allow the relaxation of social distancing measures, few countries worldwide have succeeded in scaling such efforts to levels that suppress spread. The efficacy of test-trace-isolate likely depends on the speed and extent of follow-up and the prevalence of SARS-CoV-2 in the community. Here, we u...

Endoscopic Endonasal Repair of Congenital Choanal Atresia: Predictive Factors of Surgic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329715
International Journal of Environmental Research and Publi... Ferlito S, Maniaci A et. al.

Jul 29th, 2022 - To assess the long-term outcomes and independent predictors of surgical success of a one-stage minimally invasive surgical procedure for congenital choanal atresia (C.C.A.). a retrospective multicentric study was conducted between 2010 and 2022. An endonasal endoscopic approach was performed in 38 unilateral or bilateral C.C.A. children. All the patients were clinically and radiologically asses...

A Comparison of Outcomes of Proximal and Distal Anastomosis Sites of the Facial Artery ...
https://doi.org/10.1097/SCS.0000000000008224
The Journal of Craniofacial Surgery; Stoehr JR, Curran NR et. al.

Jun 22nd, 2022 - Recipient vessel selection in head and neck reconstruction is based on multiple factors, including defect size and location, patient history, and vessel location, diameter, and length. The authors present a comparison of proximal and distal anastomotic sites of the facial artery. A chart review of head and neck reconstructions using the facial artery as a recipient vessel over a 7-year period w...

Splicing analyses for variants in MMR genes: best practice recommendations from the Eur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437034
European Journal of Human Genetics : EJHG; Morak M, Pineda M et. al.

Jun 9th, 2022 - Over 20% of the DNA mismatch repair (MMR) germline variants in suspected Lynch syndrome patients are classified as variants of uncertain significance (VUS). Well-established functional assays are pivotal for assessing the biological impact of these variants and provide relevant evidence for clinical classification. In our collaborative European Mismatch Repair Working Group (EMMR-WG) we compare...

Improving the design of RCTs in non-radiographic axial spondyloarthritis.
https://doi.org/10.1038/s41584-022-00789-1
Nature Reviews. Rheumatology; Maksymowych WP, Lambert RGW et. al.

May 14th, 2022 - Concerns have been raised that randomized placebo-controlled trials (RCTs) in non-radiographic axial spondyloarthritis (nr-axSpA) might be failing to identify patients that best show differences in clinical response rates between those receiving active drug and those receiving placebo therapies; in addition, some studies might even be showing spurious differences in responses to TNF and IL-17 i...

The COVID-19 Humoral Immunological Status Induced by CoronaVac and AstraZeneca Vaccines...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044956
Journal of Virology; Farias JP, da Silva PS et. al.

Apr 8th, 2022 - A third vaccine dose against COVID-19 is already a reality in some countries around the world. In this study, we aimed to evaluate the effectiveness of the Brazilian immunization policy for COVID-19, which involves a booster shot. Participants (n = 210) provided serum samples, which were subjected to enzyme-linked immunosorbent assay (ELISA). Immunological profiles were defined as individuals w...

Reappraising the Value of HIV-1 Vaccine Correlates of Protection Analyses.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044961
Journal of Virology; Klasse PJ, Moore JP

Apr 7th, 2022 - With the much-debated exception of the modestly reduced acquisition reported for the RV144 efficacy trial, HIV-1 vaccines have not protected humans against infection, and a vaccine of similar design to that tested in RV144 was not protective in a later trial, HVTN 702. Similar vaccine regimens have also not consistently protected nonhuman primates (NHPs) against viral acquisition. Conversely, e...

On the Need to Revitalize Descriptive Epidemiology.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9383568
American Journal of Epidemiology; Fox MP, Murray EJ et. al.

Mar 25th, 2022 - Nearly every introductory epidemiology course begins with a focus on person, place, and time, the key components of descriptive epidemiology. And yet in our experience, introductory epidemiology courses were the last time we spent any significant amount of training time focused on descriptive epidemiology. This gave us the impression that descriptive epidemiology does not suffer from bias and i...

Development and validation of a gradient boosting machine to predict prognosis after li...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915487
BMC Cancer; Ji GW, Jiao CY et. al.

Mar 13th, 2022 - Accurate prognosis assessment is essential for surgically resected intrahepatic cholangiocarcinoma (ICC) while published prognostic tools are limited by modest performance. We therefore aimed to establish a novel model to predict survival in resected ICC based on readily-available clinical parameters using machine learning technique. A gradient boosting machine (GBM) was trained and validated t...

OPTN/SRTR 2020 Annual Data Report: DOD.
https://doi.org/10.1111/ajt.16976
American Journal of Transplantation : Official Journal Of... Israni AK, Zaun D et. al.

Mar 11th, 2022 - SRTR uses data collected by OPTN to calculate metrics such as donation rate, organ yield, and rate of organs recovered for transplant but not transplanted. In 2020, there were 12,588 deceased donors, an increase from 11,870 in 2019; this number has been increasing since 2010. The number of deceased donor transplants increased to 33,303 in 2020, from 32,313 in 2019; this number has been increasi...

Determining the reliability of rapid SARS-CoV-2 antigen detection in fully vaccinated i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858005
Journal of Clinical Virology : the Official Publication O... Poopalasingam N, Korenkov M et. al.

Mar 7th, 2022 - Rapid antigen detection tests (RADT) are commonly used as SARS-CoV-2 diagnostic tests both by medical professionals and laypeople. However, the performance of RADT in vaccinated individuals has not been fully investigated. RT-qPCR and rapid antigen detection testing were performed to evaluate the performance of the Standard Q COVID-19 Ag Test in detecting SARS-CoV-2 breakthrough infections in v...

Development and Validation of an Enzyme Immunoassay for Detection and Quantification of...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916996
Journal of Immunology (Baltimore, Md. : 1950); Costantini VP, Nguyen K et. al.

Mar 2nd, 2022 - Oral fluids offer a noninvasive sampling method for the detection of Abs. Quantification of IgA and IgG Abs in saliva allows studies of the mucosal and systemic immune response after natural infection or vaccination. We developed and validated an enzyme immunoassay (EIA) to detect and quantify salivary IgA and IgG Abs against the prefusion-stabilized form of the severe acute respiratory syndrom...

Applications of artificial intelligence (AI) in ovarian cancer, pancreatic cancer, and ...
https://doi.org/10.3233/CBM-210301
Cancer Biomarkers : Section A of Disease Markers; Mikdadi D, O'Connell KA et. al.

Feb 26th, 2022 - Artificial intelligence (AI), including machine learning (ML) and deep learning, has the potential to revolutionize biomedical research. Defined as the ability to "mimic" human intelligence by machines executing trained algorithms, AI methods are deployed for biomarker discovery. We detail the advancements and challenges in the use of AI for biomarker discovery in ovarian and pancreatic cancer....

SARS-CoV-2 antigen lateral flow tests for detecting infectious people: linked data anal...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864475
BMJ (Clinical Research Ed.); Deeks JJ, Singanayagam A et. al.

Feb 25th, 2022 - To investigate the proportion of lateral flow tests (LFTs) that produce negative results in those with a high risk of infectiousness from SARS-CoV-2, to investigate the impact of the stage and severity of disease, and to compare predictions made by influential mathematical models with findings of empirical studies. Linked data analysis combining empirical evidence of the accuracy of the Innova ...

Protocol for chronic hepatitis B virus infection mouse model development by patient-der...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865695
PloS One; Nagornykh AM, Tyumentseva MA et. al.

Feb 24th, 2022 - According to the World Health Organization, more than 250 million people worldwide are chronically infected with the hepatitis B virus, and almost 800.000 patients die annually of mediated liver disorders. Therefore, adequate biological test systems are needed that could fully simulate the course of chronic hepatitis B virus infection, including in patients with hepatocellular carcinoma. In thi...

Identification of a biological form in the Anopheles stephensi laboratory colony using ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863247
PloS One; Khan J, Gholizadeh S et. al.

Feb 23rd, 2022 - Anopheles stephensi Listen (1901) is a major vector of malaria in Asia and has recently been found in some regions of Africa. The An. stepehnsi species complex is suspected to have three sibling species: type, intermediate, and mysorensis, each with its own vector competence to the malaria parasite and ecology. To identify the members of the species complex in our An. stephensi insectary colony...

Prevalence, acceptability, and cost of routine screening for pulmonary tuberculosis amo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863221
PloS One; Adjobimey M, Ade S et. al.

Feb 23rd, 2022 - We sought to evaluate the yield, cost, feasibility, and acceptability of routine tuberculosis (TB) screening of pregnant women in Cotonou, Benin. Mixed-methods, cross-sectional study with a cost assessment. Eight participating health facilities in Cotonou, Benin. Consecutive pregnant women presenting for antenatal care at any participating site who were not in labor or currently being treated f...

Protocol for the diagnosis of keratoconus using convolutional neural networks.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856512
PloS One; Schatteburg J, Langenbucher A

Feb 19th, 2022 - Keratoconus is the corneal disease with the highest reported incidence of 1:2000. The treatment's level of success highly depends on how early it was started. Subsequently, a fast and highly capable diagnostic tool is crucial. While there are many computer-based systems that are capable of the analysis of medical image data, they only provide parameters. These have advanced quite far, though fu...