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About 20,180 results

The COVID-19 Humoral Immunological Status Induced by CoronaVac and AstraZeneca Vaccines...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044956
Journal of Virology; Farias JP, da Silva PS et. al.

Apr 8th, 2022 - A third vaccine dose against COVID-19 is already a reality in some countries around the world. In this study, we aimed to evaluate the effectiveness of the Brazilian immunization policy for COVID-19, which involves a booster shot. Participants (n = 210) provided serum samples, which were subjected to enzyme-linked immunosorbent assay (ELISA). Immunological profiles were defined as individuals w...

Development and validation of a gradient boosting machine to predict prognosis after li...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915487
BMC Cancer; Ji GW, Jiao CY et. al.

Mar 13th, 2022 - Accurate prognosis assessment is essential for surgically resected intrahepatic cholangiocarcinoma (ICC) while published prognostic tools are limited by modest performance. We therefore aimed to establish a novel model to predict survival in resected ICC based on readily-available clinical parameters using machine learning technique. A gradient boosting machine (GBM) was trained and validated t...

Determining the reliability of rapid SARS-CoV-2 antigen detection in fully vaccinated i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858005
Journal of Clinical Virology : the Official Publication O... Poopalasingam N, Korenkov M et. al.

Mar 7th, 2022 - Rapid antigen detection tests (RADT) are commonly used as SARS-CoV-2 diagnostic tests both by medical professionals and laypeople. However, the performance of RADT in vaccinated individuals has not been fully investigated. RT-qPCR and rapid antigen detection testing were performed to evaluate the performance of the Standard Q COVID-19 Ag Test in detecting SARS-CoV-2 breakthrough infections in v...

Development and Validation of an Enzyme Immunoassay for Detection and Quantification of...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916996
Journal of Immunology (Baltimore, Md. : 1950); Costantini VP, Nguyen K et. al.

Mar 2nd, 2022 - Oral fluids offer a noninvasive sampling method for the detection of Abs. Quantification of IgA and IgG Abs in saliva allows studies of the mucosal and systemic immune response after natural infection or vaccination. We developed and validated an enzyme immunoassay (EIA) to detect and quantify salivary IgA and IgG Abs against the prefusion-stabilized form of the severe acute respiratory syndrom...

Applications of artificial intelligence (AI) in ovarian cancer, pancreatic cancer, and ...
https://doi.org/10.3233/CBM-210301
Cancer Biomarkers : Section A of Disease Markers; Mikdadi D, O'Connell KA et. al.

Feb 26th, 2022 - Artificial intelligence (AI), including machine learning (ML) and deep learning, has the potential to revolutionize biomedical research. Defined as the ability to "mimic" human intelligence by machines executing trained algorithms, AI methods are deployed for biomarker discovery. We detail the advancements and challenges in the use of AI for biomarker discovery in ovarian and pancreatic cancer....

SARS-CoV-2 antigen lateral flow tests for detecting infectious people: linked data anal...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864475
BMJ (Clinical Research Ed.); Deeks JJ, Singanayagam A et. al.

Feb 25th, 2022 - To investigate the proportion of lateral flow tests (LFTs) that produce negative results in those with a high risk of infectiousness from SARS-CoV-2, to investigate the impact of the stage and severity of disease, and to compare predictions made by influential mathematical models with findings of empirical studies. Linked data analysis combining empirical evidence of the accuracy of the Innova ...

Protocol for chronic hepatitis B virus infection mouse model development by patient-der...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865695
PloS One; Nagornykh AM, Tyumentseva MA et. al.

Feb 24th, 2022 - According to the World Health Organization, more than 250 million people worldwide are chronically infected with the hepatitis B virus, and almost 800.000 patients die annually of mediated liver disorders. Therefore, adequate biological test systems are needed that could fully simulate the course of chronic hepatitis B virus infection, including in patients with hepatocellular carcinoma. In thi...

Identification of a biological form in the Anopheles stephensi laboratory colony using ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863247
PloS One; Khan J, Gholizadeh S et. al.

Feb 23rd, 2022 - Anopheles stephensi Listen (1901) is a major vector of malaria in Asia and has recently been found in some regions of Africa. The An. stepehnsi species complex is suspected to have three sibling species: type, intermediate, and mysorensis, each with its own vector competence to the malaria parasite and ecology. To identify the members of the species complex in our An. stephensi insectary colony...

Prevalence, acceptability, and cost of routine screening for pulmonary tuberculosis amo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863221
PloS One; Adjobimey M, Ade S et. al.

Feb 23rd, 2022 - We sought to evaluate the yield, cost, feasibility, and acceptability of routine tuberculosis (TB) screening of pregnant women in Cotonou, Benin. Mixed-methods, cross-sectional study with a cost assessment. Eight participating health facilities in Cotonou, Benin. Consecutive pregnant women presenting for antenatal care at any participating site who were not in labor or currently being treated f...

Protocol for the diagnosis of keratoconus using convolutional neural networks.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856512
PloS One; Schatteburg J, Langenbucher A

Feb 19th, 2022 - Keratoconus is the corneal disease with the highest reported incidence of 1:2000. The treatment's level of success highly depends on how early it was started. Subsequently, a fast and highly capable diagnostic tool is crucial. While there are many computer-based systems that are capable of the analysis of medical image data, they only provide parameters. These have advanced quite far, though fu...

Age-specific effectiveness of a tuberculosis screening intervention in children.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856528
PloS One; Brooks MB, Dubois MM et. al.

Feb 19th, 2022 - To apply a cascade-of-care framework to evaluate the effectiveness-by age of the child-of an intensified tuberculosis patient-finding intervention. From a prospective screening program at four hospitals in Pakistan (2014-2016) we constructed a care cascade comprising six steps: screened, positive screen, evaluated, diagnosed, started treatment, and successful outcome. We evaluated the cascade b...

Analysis of COVID-19 Risk Following a Ring Vaccination Intervention to Address SARS-CoV...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837915
JAMA Network Open; Périnet S, Cadieux G et. al.

Feb 12th, 2022 - Given limited COVID-19 vaccine availability early in the pandemic, optimizing immunization strategies was of paramount importance. Ring vaccination has been used successfully to control transmission of other airborne respiratory viruses. To assess the association of a ring vaccination intervention on COVID-19 spread in the initial epicenter of SARS-CoV-2 Alpha variant transmission in Montreal, ...

Independent Assessment of the Children's Hepatic Tumors International Collaboration Ris...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837914
JAMA Network Open; Zhou S, Malvar J et. al.

Feb 12th, 2022 - Hepatoblastoma is the most common pediatric liver malignant neoplasm, and accurate risk stratification is essential for guiding treatment. To validate the Children's Hepatic Tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) in an independent cohort of patients with hepatoblastoma and evaluate the association of pretreatment hepatoblastoma histological subtype with progn...

Trends in Sentinel Lymph Node Biopsies in Patients With Inflammatory Breast Cancer in t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837909
JAMA Network Open; Sosa A, Lei X et. al.

Feb 12th, 2022 - The standard of care for inflammatory breast cancer (IBC) is neoadjuvant chemotherapy, total mastectomy with axillary lymph node dissection (ALND), and postmastectomy radiation therapy. Existing studies suggest that sentinel lymph node biopsy (SLNB) may not be reliable in IBC. The use and frequency of SLNB in women with IBC is not well characterized. To determine the frequency and temporal tren...

A qualitative study on safety perception among healthcare workers of a tertiary academi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821840
Antimicrobial Resistance and Infection Control; Ehrenzeller S, Durovic A et. al.

Feb 10th, 2022 - Protecting healthcare workers (HCWs) from exposure to SARS-CoV-2 during patient care is central to managing the current pandemic. Higher levels of trust in personal protective equipment (PPE) and infection prevention and control (IPC) strategies have been previously related to lower levels of emotional exhaustion, yet little is known on how to achieve such a perception of safety. We thus sought...

SARS-CoV-2 Prevention Measures Concomitantly Attenuate Methicillin-Resistant Staphyloco...
https://doi.org/10.1177/00099228211067898
Clinical Pediatrics; Dalabih A, Young HL et. al.

Feb 9th, 2022 - SARS-CoV-2 Prevention Measures Concomitantly Attenuate Methicillin-Resistant Staphylococcus aureus Infection Rates.|2022|Dalabih A,Young HL,Frenner RA,Stroud MH,Boyanton BL,|epidemiology,epidemiology,prevention & control,methods,standards,trends,pathogenicity,methods,standards,trends,epidemiology,prevention & control,

The applications of DNA methylation as a biomarker in kidney transplantation: a systema...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822833
Clinical Epigenetics; Cristoferi I, Giacon TA et. al.

Feb 9th, 2022 - Although kidney transplantation improves patient survival and quality of life, long-term results are hampered by both immune- and non-immune-mediated complications. Current biomarkers of post-transplant complications, such as allograft rejection, chronic renal allograft dysfunction, and cutaneous squamous cell carcinoma, have a suboptimal predictive value. DNA methylation is an epigenetic modif...

Diagnostic accuracy of serological tests for the diagnosis of Chikungunya virus infecti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849447
PLoS Neglected Tropical Diseases; Andrew A, Navien TN et. al.

Feb 5th, 2022 - Chikungunya virus (CHIKV) causes febrile illnesses and has always been misdiagnosed as other viral infections, such as dengue and Zika; thus, a laboratory test is needed. Serological tests are commonly used to diagnose CHIKV infection, but their accuracy is questionable due to varying degrees of reported sensitivities and specificities. Herein, we conducted a systematic review and meta-analysis...

Malaria prevention interventions beyond long-lasting insecticidal nets and indoor resid...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812253
Malaria Journal; Nalinya S, Musoke D et. al.

Feb 4th, 2022 - Significant progress in malaria prevention during the past two decades has prompted increasing global dialogue on malaria elimination. Recent reviews on malaria strategies have focused mainly on long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), with little emphasis on other prevention methods. This article is a scoping review of literature on malaria prevention methods ...

2022 American College of Rheumatology/European Alliance of Associations for Rheumatolog...
https://doi.org/10.1136/annrheumdis-2021-221795
Annals of the Rheumatic Diseases; Robson JC, Grayson PC et. al.

Feb 4th, 2022 - To develop and validate revised classification criteria for granulomatosis with polyangiitis (GPA). Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in five phases: (1) identification of candidate criteria items using consensus methodology, (2) prospective collection of candidate items present at the time of diagnosis, (3) data-dri...