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About 20,420 results

Monkeypox - A Sobering Sentinel for Pandemic Preparedness and Sexual Health System Capa...
https://doi.org/10.1056/NEJMp2212262
The New England Journal of Medicine; Golden MR, Wasserheit JN

Nov 3rd, 2022 - Monkeypox - A Sobering Sentinel for Pandemic Preparedness and Sexual Health System Capacity.|2022|Golden MR,Wasserheit JN,|epidemiology,epidemiology,prevention & control,prevention & control,standards,standards,standards,standards,standards,standards,

Children With Sickle Cell Anemia Not Receiving Recommended Care.
https://doi.org/10.1001/jama.2022.15489
JAMA Kuehn BM

Oct 26th, 2022 - Children With Sickle Cell Anemia Not Receiving Recommended Care.|2022|Kuehn BM,|complications,therapy,standards,standards,

Semi-automated assembly of high-quality diploid human reference genomes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668749
Nature Jarvis ED, Formenti G et. al.

Oct 20th, 2022 - The current human reference genome, GRCh38, represents over 20 years of effort to generate a high-quality assembly, which has benefitted society1,2. However, it still has many gaps and errors, and does not represent a biological genome as it is a blend of multiple individuals3,4. Recently, a high-quality telomere-to-telomere reference, CHM13, was generated with the latest long-read technologies...

Hydroxychloroquine Dose per Ophthalmology Guidelines and the Risk of Systemic Lupus Ery...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554698
JAMA Jorge AM, Mancini C et. al.

Sep 17th, 2022 - Hydroxychloroquine Dose per Ophthalmology Guidelines and the Risk of Systemic Lupus Erythematosus Flares.|2022|Jorge AM,Mancini C,Zhou B,Ho G,Zhang Y,|adverse effects,therapeutic use,chemically induced,administration & dosage,adverse effects,drug therapy,prevention & control,standards,standards,

Validity of at-home rapid antigen lateral flow assay and artificial intelligence read t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259514
Diagnostic Microbiology and Infectious Disease; Richardson S, Kohn MA et. al.

Sep 8th, 2022 - The gold standard for COVID-19 diagnosis-reverse-transcriptase polymerase chain reaction (RT-PCR)- is expensive and often slow to yield results whereas lateral flow tests can lack sensitivity. We tested a rapid, lateral flow antigen (LFA) assay with artificial intelligence read (LFAIR) in subjects from COVID-19 treatment trials (N = 37; daily tests for 5 days) and from a population-based study ...

Diagnostic performance of mycological tests for invasive pulmonary aspergillosis in non...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438090
BMJ Open; Liu M, Cheng G et. al.

Aug 30th, 2022 - Increasing numbers of patients with non-haematological diseases are infected with invasive pulmonary aspergillosis (IPA), with a high mortality reported which is mainly due to delayed diagnosis. The diagnostic capability of mycological tests for IPA including galactomannan test, (1,3)-β-D-glucan test, lateral flow assay, lateral flow device and PCR for the non-haematological patients remains un...

Validation of the German eHealth impact questionnaire for online health information use...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380659
BMC Medical Informatics and Decision Making; Sippel A, Riemann-Lorenz K et. al.

Aug 17th, 2022 - Persons with multiple sclerosis (MS) are confronted by an overwhelming amount of online health information, which can be valuable but also vary in quality and aim. Therefore, it is of great importance for developers and providers of eHealth information to understand its impact on the users. The eHealth Impact Questionnaire (eHIQ) has been developed in the United Kingdom to measure the potential...

The effectiveness of COVID-19 testing and contact tracing in a US city.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407477
Proceedings of the National Academy of Sciences of the Un... Wang X, Du Z et. al.

Aug 16th, 2022 - Although testing, contact tracing, and case isolation programs can mitigate COVID-19 transmission and allow the relaxation of social distancing measures, few countries worldwide have succeeded in scaling such efforts to levels that suppress spread. The efficacy of test-trace-isolate likely depends on the speed and extent of follow-up and the prevalence of SARS-CoV-2 in the community. Here, we u...

Endoscopic Endonasal Repair of Congenital Choanal Atresia: Predictive Factors of Surgic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329715
International Journal of Environmental Research and Publi... Ferlito S, Maniaci A et. al.

Jul 29th, 2022 - To assess the long-term outcomes and independent predictors of surgical success of a one-stage minimally invasive surgical procedure for congenital choanal atresia (C.C.A.). a retrospective multicentric study was conducted between 2010 and 2022. An endonasal endoscopic approach was performed in 38 unilateral or bilateral C.C.A. children. All the patients were clinically and radiologically asses...

A Comparison of Outcomes of Proximal and Distal Anastomosis Sites of the Facial Artery ...
https://doi.org/10.1097/SCS.0000000000008224
The Journal of Craniofacial Surgery; Stoehr JR, Curran NR et. al.

Jun 22nd, 2022 - Recipient vessel selection in head and neck reconstruction is based on multiple factors, including defect size and location, patient history, and vessel location, diameter, and length. The authors present a comparison of proximal and distal anastomotic sites of the facial artery. A chart review of head and neck reconstructions using the facial artery as a recipient vessel over a 7-year period w...

Amplifying patient voices amid pandemic: Perspectives on tracheostomy care, communicati...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172276
American Journal of Otolaryngology; Pandian V, Hopkins BS et. al.

Jun 20th, 2022 - To investigate perspectives of patients, family members, caregivers (PFC), and healthcare professionals (HCP) on tracheostomy care during the COVID-19 pandemic. The cross-sectional survey investigating barriers and facilitators to tracheostomy care was collaboratively developed by patients, family members, nurses, speech-language pathologists, respiratory care practitioners, physicians, and sur...

Splicing analyses for variants in MMR genes: best practice recommendations from the Eur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437034
European Journal of Human Genetics : EJHG; Morak M, Pineda M et. al.

Jun 9th, 2022 - Over 20% of the DNA mismatch repair (MMR) germline variants in suspected Lynch syndrome patients are classified as variants of uncertain significance (VUS). Well-established functional assays are pivotal for assessing the biological impact of these variants and provide relevant evidence for clinical classification. In our collaborative European Mismatch Repair Working Group (EMMR-WG) we compare...

Improving the design of RCTs in non-radiographic axial spondyloarthritis.
https://doi.org/10.1038/s41584-022-00789-1
Nature Reviews. Rheumatology; Maksymowych WP, Lambert RGW et. al.

May 14th, 2022 - Concerns have been raised that randomized placebo-controlled trials (RCTs) in non-radiographic axial spondyloarthritis (nr-axSpA) might be failing to identify patients that best show differences in clinical response rates between those receiving active drug and those receiving placebo therapies; in addition, some studies might even be showing spurious differences in responses to TNF and IL-17 i...

The COVID-19 Humoral Immunological Status Induced by CoronaVac and AstraZeneca Vaccines...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044956
Journal of Virology; Farias JP, da Silva PS et. al.

Apr 8th, 2022 - A third vaccine dose against COVID-19 is already a reality in some countries around the world. In this study, we aimed to evaluate the effectiveness of the Brazilian immunization policy for COVID-19, which involves a booster shot. Participants (n = 210) provided serum samples, which were subjected to enzyme-linked immunosorbent assay (ELISA). Immunological profiles were defined as individuals w...

Reappraising the Value of HIV-1 Vaccine Correlates of Protection Analyses.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044961
Journal of Virology; Klasse PJ, Moore JP

Apr 7th, 2022 - With the much-debated exception of the modestly reduced acquisition reported for the RV144 efficacy trial, HIV-1 vaccines have not protected humans against infection, and a vaccine of similar design to that tested in RV144 was not protective in a later trial, HVTN 702. Similar vaccine regimens have also not consistently protected nonhuman primates (NHPs) against viral acquisition. Conversely, e...

On the Need to Revitalize Descriptive Epidemiology.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9383568
American Journal of Epidemiology; Fox MP, Murray EJ et. al.

Mar 25th, 2022 - Nearly every introductory epidemiology course begins with a focus on person, place, and time, the key components of descriptive epidemiology. And yet in our experience, introductory epidemiology courses were the last time we spent any significant amount of training time focused on descriptive epidemiology. This gave us the impression that descriptive epidemiology does not suffer from bias and i...

Development and validation of a gradient boosting machine to predict prognosis after li...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915487
BMC Cancer; Ji GW, Jiao CY et. al.

Mar 13th, 2022 - Accurate prognosis assessment is essential for surgically resected intrahepatic cholangiocarcinoma (ICC) while published prognostic tools are limited by modest performance. We therefore aimed to establish a novel model to predict survival in resected ICC based on readily-available clinical parameters using machine learning technique. A gradient boosting machine (GBM) was trained and validated t...

OPTN/SRTR 2020 Annual Data Report: DOD.
https://doi.org/10.1111/ajt.16976
American Journal of Transplantation : Official Journal Of... Israni AK, Zaun D et. al.

Mar 11th, 2022 - SRTR uses data collected by OPTN to calculate metrics such as donation rate, organ yield, and rate of organs recovered for transplant but not transplanted. In 2020, there were 12,588 deceased donors, an increase from 11,870 in 2019; this number has been increasing since 2010. The number of deceased donor transplants increased to 33,303 in 2020, from 32,313 in 2019; this number has been increasi...

Determining the reliability of rapid SARS-CoV-2 antigen detection in fully vaccinated i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858005
Journal of Clinical Virology : the Official Publication O... Poopalasingam N, Korenkov M et. al.

Mar 7th, 2022 - Rapid antigen detection tests (RADT) are commonly used as SARS-CoV-2 diagnostic tests both by medical professionals and laypeople. However, the performance of RADT in vaccinated individuals has not been fully investigated. RT-qPCR and rapid antigen detection testing were performed to evaluate the performance of the Standard Q COVID-19 Ag Test in detecting SARS-CoV-2 breakthrough infections in v...

Development and Validation of an Enzyme Immunoassay for Detection and Quantification of...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916996
Journal of Immunology (Baltimore, Md. : 1950); Costantini VP, Nguyen K et. al.

Mar 2nd, 2022 - Oral fluids offer a noninvasive sampling method for the detection of Abs. Quantification of IgA and IgG Abs in saliva allows studies of the mucosal and systemic immune response after natural infection or vaccination. We developed and validated an enzyme immunoassay (EIA) to detect and quantify salivary IgA and IgG Abs against the prefusion-stabilized form of the severe acute respiratory syndrom...