×
About 46,758 results

Evolving Patterns of Metastasis in Renal Cell Carcinoma: Do We Need to Perform Routine Bone Imaging?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523177/
Journal of Kidney Cancer and VHL; Lin J

Oct 13th, 2021 - Advance diagnostic and treatment modalities have improved outcomes for renal cell carcinoma (RCC) patients, but the prognosis for those with metastatic disease (mRCC) remains poor. As given metastatic distribution is critical in guiding treatment decisions for mRCC patients, we evaluated evolving metastatic patterns to assess if our current practice standards effectively address patient needs.

An upper bound on one-to-one exposure to infectious human respiratory particles.
https://doi.org/10.1073/pnas.2110117118
Proceedings of the National Academy of Sciences of the Un... Bagheri G, Thiede B et. al.

Dec 4th, 2021 - There is ample evidence that masking and social distancing are effective in reducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. However, due to the complexity of airborne disease transmission, it is difficult to quantify their effectiveness, especially in the case of one-to-one exposure. Here, we introduce the concept of an upper bound for one-to-one exposure to ...

Biodistribution and radiation dosimetry of intraperitoneally administered 124I-omburtam...
https://doi.org/10.2967/jnumed.121.262793
Journal of Nuclear Medicine : Official Publication, Socie... Grkovski M, Modak S et. al.

Dec 4th, 2021 - The aim of this study was to assess the pharmacokinetics, biodistribution, and radiation dosimetry of 124I-omburtamab administered intraperitoneally in patients with desmoplastic small round cell tumor (DSRCT). Methods: Eligible patients diagnosed with DSRCT with peritoneal involvement were enrolled in a phase I trial of intraperitoneal radioimmunotherapy with 131I-omburtamab (NCT01099644). Aft...

Revisiting oral thrush in Southeast Asian patients: A review of published studies (2000...
https://doi.org/10.1111/jop.13266
Journal of Oral Pathology & Medicine : Official Publicati... Karajacob AS, Mohammed Al Maleki AR et. al.

Dec 4th, 2021 - Oral thrush, a clinical condition due to an overgrowth of Candida yeasts in the oral cavity, is prominent in patients with immunosuppression. As recent updates on oral thrush in Southeast Asia (SEA) countries are lacking, this review aims to address the epidemiology, clinical features, and distribution of Candida species, based on published studies in SEA over the last two decades. Published st...

Prevalence of potential mediators of artemisinin resistance in African isolates of Plas...
https://doi.org/10.1186/s12936-021-03987-6
Malaria Journal; Owoloye A, Olufemi M et. al.

Dec 4th, 2021 - The devastating public health impact of malaria has prompted the need for effective interventions. Malaria control gained traction after the introduction of artemisinin-based combination therapy (ACT). However, the emergence of artemisinin (ART) partial resistance in Southeast Asia and emerging reports of delayed parasite sensitivity to ACT in African parasites signal a gradual trend towards tr...

Exploring the COVID-19 vaccine candidates against SARS-CoV-2 and its variants: where do...
https://doi.org/10.1080/21645515.2021.1995283
Human Vaccines & Immunotherapeutics; Joshi G, Borah P et. al.

Dec 4th, 2021 - As of September 2021, 117 COVID-19 vaccines are in clinical development, and 194 are in preclinical development as per the World Health Organization (WHO) published draft landscape. Among the 117 vaccines undergoing clinical trials, the major platforms include protein subunit; RNA; inactivated virus; viral vector, among others. So far, USFDA recognized to approve the Pfizer-BioNTech (Comirnaty)...

Treatment persistence to tolvaptan in patients with autosomal dominant polycystic kidne...
https://doi.org/10.1186/s12882-021-02607-4 10.1038/s41572-018-0047-y 10.1016/S0140-6736(07)60601-1 10.1056/NEJMoa1710030 10.1056/NEJMoa1205511 10.1111/j.0306-5251.2003.02054.x 10.18553/jmcp.2020.26.1.67 10.1007/s11739-019-02100-9 10.1016/j.ekir.2017.07.004 10.1007/s40264-015-0327-3
BMC Nephrology; Thomas M, Gois PHF et. al.

Dec 4th, 2021 - Tolvaptan is the only available disease-modifying treatment for autosomal dominant polycystic kidney disease (ADPKD). Prior to October 2020 access to tolvaptan in Australia was restricted by a controlled monitoring and distribution program called IMADJIN®. Focusing on hepatic safety, the IMADJIN® program collected real-world data on patients with ADPKD. A retrospective, secondary data analysis ...

Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV
https://clinicaltrials.gov/ct2/show/NCT04514484

Dec 3rd, 2021 - PRIMARY OBJECTIVES: I. To determine the safety of combined nivolumab and cabozantinib s-malate (XL184 [cabozantinib]) in human immunodeficiency virus (HIV) patients with advanced solid tumors. II. To determine the feasibility to deliver the combined nivolumab and XL184 (cabozantinib) for a minimum of 4 cycles in at least 75% of the subjects in the expanded cohort with Kaposi sarcoma (KS) or to ...

Identification of public submitted tick images: A neural network approach.
https://doi.org/10.1371/journal.pone.0260622
PloS One; Justen L, Carlsmith D et. al.

Dec 3rd, 2021 - Ticks and tick-borne diseases represent a growing public health threat in North America and Europe. The number of ticks, their geographical distribution, and the incidence of tick-borne diseases, like Lyme disease, are all on the rise. Accurate, real-time tick-image identification through a smartphone app or similar platform could help mitigate this threat by informing users of the risks associ...

Lost in third space: altered tyrosine-kinase inhibitor pharmacokinetics in a patient wi...
https://doi.org/10.1007/s00280-021-04377-0 10.1016/j.ygyno.2010.05.033 10.1016/j.urolonc.2016.10.023 10.1002/jso.25453 10.1038/modpathol.2009.88 10.1007/s00280-019-03952-w 10.1038/bjc.2014.503 10.1007/s00280-009-1170-y 10.1007/s10637-015-0304-9 10.1007/s13277-015-4198-0 10.1007/s11523-014-0306-0 10.1080/0284186X.2017.1311024 10.1177/2054270415585087 10.1007/s13691-012-0039-9 10.1158/1078-0432.CCR-12-2199 10.1007/s00262-020-02621-9
Cancer Chemotherapy and Pharmacology; Krens SD, Mulder SF et. al.

Dec 3rd, 2021 - Pazopanib and sunitinib are oral tyrosine kinase inhibitors (TKI) approved for the treatment of renal cell carcinoma. For both oncolytics, a clear target trough concentration level in plasma has been defined above which improved clinical efficacy can be expected. However, many factors can alter TKI exposure, including disease characteristics. A 79-year old male with metastatic papillary renal c...

Evaluation of ocular blood flow by Doppler ultrasound in patients with essential blepha...
https://doi.org/10.1007/s40477-021-00613-8 10.1093/brain/108.3.593 10.4274/tjo.27879 10.1016/j.nicl.2018.06.004 10.1007/s00415-014-7359-y 10.1111/j.1468-1331.2007.02034.x 10.1097/WNO.0b013e31828f69e5 10.1016/j.neulet.2017.09.014 10.1212/01.WNL.0000063306.67984.8C 10.1097/00041327-200303000-00003 10.1007/s00417-006-0392-5 10.1038/eye.1993.147 10.7863/jum.1993.12.8.473 10.1038/eye.1993.16 10.1186/1471-2474-13-209
Journal of Ultrasound; Kesimal B, Kesimal U et. al.

Dec 3rd, 2021 - Benign essential blepharospasm (EB) is a focal facial dyskinesia that occurs with the involuntary contraction of muscles around the eyes. In the literature, studies on blepharospasm focus on elucidating the pathophysiology of this condition in the brain. To the best of our knowledge, there is no research evaluating the orbital imaging findings of patients with EB. Therefore, the current study a...

Hepatitis B virus infection and the risk of gastrointestinal cancers among Chinese popu...
https://doi.org/10.1002/ijc.33891
International Journal of Cancer; Liu T, Song C et. al.

Dec 3rd, 2021 - This study aims to explore the relationship between chronic hepatitis B virus (HBV) infection and the risk of gastrointestinal (GI) cancers including liver, gastric, gallbladder or extrahepatic bile duct, pancreatic, small intestine, esophageal, and colorectal cancer in the Kailuan Cohort study. We prospectively examined the relationship between HBV infection and new-onset GI cancers among 93,4...

Progressive Multifocal Leukoencephalopathy Misdiagnosed as Neuropsychiatric Systemic Lu...
https://doi.org/10.1097/NRL.0000000000000398
The Neurologist; Algahtani H, Shirah B et. al.

Dec 3rd, 2021 - Progressive multifocal leukoencephalopathy (PML) is a rare infection of the central nervous system due to the reactivation of the John Cunningham polyomavirus. It is commonly a progressive fatal disease with worldwide distribution. We describe a rare case of PML, which was misdiagnosed as neuropsychiatric systemic lupus erythematosus (SLE) with a catastrophic outcome due to delay in diagnosis w...

Preoperative Evaluation of Central Lymph Nodes in Papillary Thyroid Carcinoma Using Hig...
https://doi.org/10.1097/RUQ.0000000000000518
Ultrasound Quarterly; Liu Y, Li S et. al.

Dec 3rd, 2021 - The aim of this study was to discuss the diagnostic value of high-resolution ultrasound and virtual touch tissue imaging quantification (VTIQ) for distinguishing metastatic and benign central lymph nodes (CLNs) in patients with papillary thyroid carcinoma. This retrospective study involved 86 pathologically proven benign lymph nodes (LNs) and 118 metastatic LNs in patients with papillary thyroi...

Population pharmacokinetics of valproic acid in adult Chinese patients with bipolar dis...
https://doi.org/10.1007/s00228-021-03246-2 10.1016/S0140-6736(20)31544-0 10.1016/j.neubiorev.2020.12.031 10.1016/S2215-0366(15)00505-2 10.1001/archgenpsychiatry.2011.12 10.1034/j.1399-5618.2003.00031.x 10.1097/01.WNF.0000228209.69524.E8 10.1038/s41380-018-0044-2 10.1002/14651858.CD004052 10.1111/bdi.12609 10.1176/appi.ajp.163.2.272 10.1055/s-0043-116492 10.1097/FTD.0000000000000100 10.1176/ajp.153.6.765 10.2165/11634080-000000000-00000 10.1007/s00228-020-02873-5 10.1002/j.1552-4604.1997.tb04301.x 10.1002/(sici)1099-081x(199907)20:5<233::aid-bdd179>3.0.co;2-5 10.1046/j.1365-2710.2003.00528.x 10.1358/mf.2007.29.10.1116313 10.1016/j.ejps.2009.09.017 10.5414/cpp48767 10.1007/s10928-013-9323-3 10.1371/journal.pone.0111066 10.1007/s11096-019-00864-w 10.1007/s11095-006-9067-5 10.1016/j.cmpb.2007.12.002 10.1093/jac/dkq449 10.1097/00007691-200306000-00005 10.1111/j.1365-2125.2012.04406.x 10.1111/bcp.12830 10.1097/FTD.0b013e31811f3296 10.1016/j.clinthera.2017.04.005 10.1177/0300060520952281 10.1007/s00228-018-2440-6 10.1111/bcp.13510 10.1097/FPC.0b013e32835ea0b2 10.3349/ymj.2014.55.1.232 10.1038/tpj.2015.70 10.1007/BF03256440 10.1007/s00228-009-0712-x 10.1016/j.eplepsyres.2015.04.015 10.1007/s00228-017-2395-z 10.1155/2015/542862 10.1016/j.cca.2006.08.026 10.1111/j.1528-1167.2008.01561.x 10.1176/ajp.2006.163.11.1891 10.1016/j.psym.2018.07.009 10.1016/S0074-7742(08)00001-9 10.3109/03602530903209288 10.1016/j.phrs.2006.11.001 10.1097/00007691-200208000-00012 10.2165/00003495-198224060-00004 10.1097/00004583-200108000-00003 10.1097/00004583-200206000-00002 10.1097/00004583-200301000-00001 10.1016/j.phrs.2016.02.014 10.2165/00002018-200629020-00001 10.3109/13651509909068397
European Journal of Clinical Pharmacology; Zang YN, Guo W et. al.

Dec 3rd, 2021 - To develop and validate a population pharmacokinetic (PPK) model of valproic acid (VPA) in adult Chinese patients with bipolar disorder, and provide guidance for individualized therapy in this population. A total of 1104 serum concentrations from 272 patients were collected in this study. The data analysis was performed using a nonlinear mixed-effects modeling approach. Covariates included demo...

Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lew...
https://doi.org/10.1007/s00401-021-02383-3 10.1002/ana.21154 10.1007/s00401-014-1358-z 10.1093/jnen/nlz126 10.1016/S0197-4580(02)00065-9PMID-12498954 10.1038/s41588-021-00785-3 10.1002/alz.12079 10.1016/j.jmb.2021.166953 10.1159/000289231 10.1016/0022-3956(75)90026-6 10.1007/s00401-013-1239-x 10.1016/j.brainres.2007.09.048 10.1111/bpa.12773 10.1016/s1474-4422(17)30284-3 10.1007/s00401-018-1951-7PMID-30604226 10.1007/s00401-013-1211-9 10.1007/s00401-016-1537-1 10.1002/ana.24493 10.1001/jamaneurol.2020.1741 10.1007/s00401-020-02211-0 10.1186/s40478-018-0641-y 10.1186/s40478-018-0552-y 10.1111/bpa.12424 10.1212/WNL.0000000000004058 10.1212/01.wnl.0000187889.17253.b1PMID-16237129 10.1016/j.neurobiolaging.2013.11.029 10.1016/j.nbd.2020.105130 10.1016/j.jalz.2015.07.492 10.1007/s00401-011-0910-3 10.1007/s00401-014-1302-2 10.1002/ana.24388 10.1111/neup.12673 10.1007/s00401-007-0261-2 10.1097/NEN.0b013e31825018f7 10.1097/NEN.0b013e3181919a48 10.1093/brain/awz099 10.1097/nen.0000000000000151 10.1093/brain/awt318 10.1007/s00401-020-02207-wPMID-32778941 10.1126/science.1134108 10.1038/jcbfm.2015.164 10.1093/brain/awy146 10.1093/brain/awaa219 10.1111/bpa.12505 10.7150/ijbs.7.234 10.1016/j.jalz.2013.06.003 10.1007/s00401-021-02295-2 10.1002/ana.25486PMID-30973966 10.1038/ng.536 10.1016/S0140-6736(15)00462-6 10.1016/j.jalz.2010.08.233 10.1212/wnl.0000000000001313
Acta Neuropathologica; Uemura MT, Robinson JL et. al.

Dec 3rd, 2021 - Limbic-predominant age-related TDP-43 encephalopathy (LATE) is characterized by the accumulation of TAR-DNA-binding protein 43 (TDP-43) aggregates in older adults. LATE coexists with Lewy body disease (LBD) as well as other neuropathological changes including Alzheimer's disease (AD). We aimed to identify the pathological, clinical, and genetic characteristics of LATE in LBD (LATE-LBD) by compa...

Epidemiology of Schistosoma mansoni infection in Ituri Province, north-eastern Democrat...
https://doi.org/10.1371/journal.pntd.0009486
PLoS Neglected Tropical Diseases; Nigo MM, Odermatt P et. al.

Dec 3rd, 2021 - Schistosomiasis, caused by Schistosoma mansoni, is of great significance to public health in sub-Saharan Africa. In the Democratic Republic of Congo (DRC), information on the burden of S. mansoni infection is scarce, which hinders the implementation of adequate control measures. We assessed the geographical distribution of S. mansoni infection across Ituri province in north-eastern DRC and dete...

Cetyltrimethylammonium Bromide Disrupts Mesenchymal Characteristics of Human Tongue Squ...
https://doi.org/10.21873/anticanres.15429
Anticancer Research; Yue CH, Chen CH et. al.

Dec 2nd, 2021 - This study investigated the anti-metastatic effects of cetyltrimethylammonium bromide (CTAB) on tongue squamous cell carcinoma (TSCC) SCC4 cells. Cell morphology, viability, cell cycle distribution, adhesion, migration, invasion and the expression levels of associated proteins were examined using microscopy, WST-1, wound-healing, Boyden chamber assays, and western blotting, respectively. CTAB s...

CFTR limits F-actin formation and promotes morphological alignment with flow in human l...
https://doi.org/10.14814/phy2.15128
Physiological Reports; Causer AJ, Khalaf M et. al.

Dec 2nd, 2021 - Micro- and macrovascular endothelial dysfunction in response to shear stress has been observed in cystic fibrosis (CF), and has been associated with inflammation and oxidative stress. We tested the hypothesis that the cystic fibrosis transmembrane conductance regulator (CFTR) regulates endothelial actin cytoskeleton dynamics and cellular alignment in response to flow. Human lung microvascular e...

A nucleic acid-based orthopoxvirus vaccine targeting the vaccinia virus L1, A27, B5 and...
https://doi.org/10.1128/JVI.01504-21
Journal of Virology; Mucker EM, Golden JW et. al.

Dec 2nd, 2021 - In the age of COVID, nucleic acid vaccines have garnered much attention, at least in part, because of the simplicity of construction, production, and flexibility to adjust and adapt to an evolving outbreak. Orthopoxviruses remain a threat on multiple fronts, especially as emerging zoonosis. In response, we developed a DNA vaccine, termed 4pox, that protected nonhuman primates against monkeypox ...